Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
paragraph_index
int64
sec
string
p_has_citation
int64
cites
string
citeids
list
pmid
int64
cited_id
string
sentences
string
all_sent_cites
list
sent_len
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sentence_batch_index
int64
sent_has_citation
float64
qc_fail
bool
cited_sentence
string
cites_in_sentence
list
cln_sentence
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is_cap
bool
is_alpha
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ends_wp
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cit_qc
bool
lgtm
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__index_level_0__
int64
1
INTRODUCTION
1
1
[ "B1", "B2" ]
19,503,677
NA|NA
For example, adult independence refers to a person who does not require external care in daily life, whereas child independence includes care within the family and school life.
[ "1", "2" ]
176
38,016
0
false
For example, adult independence refers to a person who does not require external care in daily life, whereas child independence includes care within the family and school life.
[]
For example, adult independence refers to a person who does not require external care in daily life, whereas child independence includes care within the family and school life.
true
true
true
true
true
6,521
1
INTRODUCTION
1
1
[ "B1", "B2" ]
19,503,677
NA|NA
Such personal factors have been nurtured through development in the community and belong to the community's values and customs.
[ "1", "2" ]
127
38,017
0
false
Such personal factors have been nurtured through development in the community and belong to the community's values and customs.
[]
Such personal factors have been nurtured through development in the community and belong to the community's values and customs.
true
true
true
true
true
6,521
1
INTRODUCTION
1
1
[ "B1", "B2" ]
19,503,677
NA|NA
The universal factors, on the other hand, are measured against the common rule of humanbeings.
[ "1", "2" ]
94
38,018
0
false
The universal factors, on the other hand, are measured against the common rule of humanbeings.
[]
The universal factors, on the other hand, are measured against the common rule of humanbeings.
true
true
true
true
true
6,521
1
INTRODUCTION
1
1
[ "B1", "B2" ]
19,503,677
NA|NA
Furthermore, disability evaluation should also include assessment for the supporting system in the community-based rehabilitation (CBR) and other problems.
[ "1", "2" ]
155
38,019
0
false
Furthermore, disability evaluation should also include assessment for the supporting system in the community-based rehabilitation (CBR) and other problems.
[]
Furthermore, disability evaluation should also include assessment for the supporting system in the community-based rehabilitation (CBR) and other problems.
true
true
true
true
true
6,521
1
INTRODUCTION
1
1
[ "B1", "B2" ]
19,503,677
NA|NA
These other problems, which relate to objective signs, the timing of evaluation and multiple impairments, are still under fierce debate.
[ "1", "2" ]
136
38,020
0
false
These other problems, which relate to objective signs, the timing of evaluation and multiple impairments, are still under fierce debate.
[]
These other problems, which relate to objective signs, the timing of evaluation and multiple impairments, are still under fierce debate.
true
true
true
true
true
6,521
2
INTRODUCTION
0
null
null
19,503,677
null
Generally, it is accepted that disabilities differ from impairment to impairment.
null
81
38,021
0
false
null
null
Generally, it is accepted that disabilities differ from impairment to impairment.
true
true
true
true
true
6,522
2
INTRODUCTION
0
null
null
19,503,677
null
In addition, the needs of patients vary by disability types.
null
60
38,022
0
false
null
null
In addition, the needs of patients vary by disability types.
true
true
true
true
true
6,522
2
INTRODUCTION
0
null
null
19,503,677
null
As such, Japan officially recognizes three forms of the identification booklet for the disabled, one for physical disability, one for mental disability, and another for psychological disability.
null
194
38,023
0
false
null
null
As such, Japan officially recognizes three forms of the identification booklet for the disabled, one for physical disability, one for mental disability, and another for psychological disability.
true
true
true
true
true
6,522
0
DISCUSSION
0
null
null
19,503,677
null
In Japan, disability is categorized under three identification booklets: 1) physical disability, which is classified by four subgroups, 2) mental disability, and 3) psychological disability.
null
190
38,024
0
false
null
null
In Japan, disability is categorized under three identification booklets: 1) physical disability, which is classified by four subgroups, 2) mental disability, and 3) psychological disability.
true
true
true
true
true
6,523
1
DISCUSSION
0
null
null
19,503,677
NA|NA
The classification of the physically disabled subgroups (Table 1-4) was very useful for determining the problems for government policy on welfare and public health.
null
164
38,025
0
false
null
null
The classification of the physically disabled subgroups (Table 1-4) was very useful for determining the problems for government policy on welfare and public health.
true
true
true
true
true
6,524
1
DISCUSSION
0
null
null
19,503,677
NA|NA
The increasing rate of internal disorders within the physically disabled has become a major theme for following global welfare services in the future.
null
150
38,026
0
false
null
null
The increasing rate of internal disorders within the physically disabled has become a major theme for following global welfare services in the future.
true
true
true
true
true
6,524
1
DISCUSSION
0
null
null
19,503,677
NA|NA
A multi-system for evaluating disabilities has resulted in many welfare services, depending on the various kinds of disabilities.
null
129
38,027
0
false
null
null
A multi-system for evaluating disabilities has resulted in many welfare services, depending on the various kinds of disabilities.
true
true
true
true
true
6,524
1
DISCUSSION
0
null
null
19,503,677
NA|NA
However, the achievements of the welfare system, based on different types of disabilities, have led to a complex or confused service system.
null
140
38,028
0
false
null
null
However, the achievements of the welfare system, based on different types of disabilities, have led to a complex or confused service system.
true
true
true
true
true
6,524
1
DISCUSSION
0
null
null
19,503,677
NA|NA
The system has also been affected yearly by the changing social community around persons with disabilities.
null
107
38,029
0
false
null
null
The system has also been affected yearly by the changing social community around persons with disabilities.
true
true
true
true
true
6,524
1
DISCUSSION
0
null
null
19,503,677
NA|NA
For example, the data showed a sharp rise in the elderly with disabilities.
null
75
38,030
0
false
null
null
For example, the data showed a sharp rise in the elderly with disabilities.
true
true
true
true
true
6,524
1
DISCUSSION
0
null
null
19,503,677
NA|NA
Accordingly, the increasing ratio of the elderly population has prompted the development of a new disability evaluation related to practical ADL.
null
145
38,031
0
false
null
null
Accordingly, the increasing ratio of the elderly population has prompted the development of a new disability evaluation related to practical ADL.
true
true
true
true
true
6,524
1
DISCUSSION
0
null
null
19,503,677
NA|NA
To cite another example, mental disability has been evaluated from infancy because of a lack of social response.
null
112
38,032
0
false
null
null
To cite another example, mental disability has been evaluated from infancy because of a lack of social response.
true
true
true
true
true
6,524
1
DISCUSSION
0
null
null
19,503,677
NA|NA
As such, most people with mental disability usually tend to receive the identification booklet up to the age of 18 yr.
null
118
38,033
0
false
null
null
As such, most people with mental disability usually tend to receive the identification booklet up to the age of 18 yr.
true
true
true
true
true
6,524
1
DISCUSSION
0
null
null
19,503,677
NA|NA
However, Table 5 shows that, in Japan, adults with mental disability tend to be less adaptive to the community than those with physical disability.
null
147
38,034
0
false
null
null
However, Table 5 shows that, in Japan, adults with mental disability tend to be less adaptive to the community than those with physical disability.
true
true
true
true
true
6,524
1
DISCUSSION
0
null
null
19,503,677
NA|NA
Therefore, the Ministry of Health, Labor and Welfare of Japanese Government has started to rearrange many welfare services to be more suitable to a small community around persons with disabilities.
null
197
38,035
0
false
null
null
Therefore, the Ministry of Health, Labor and Welfare of Japanese Government has started to rearrange many welfare services to be more suitable to a small community around persons with disabilities.
true
true
true
true
true
6,524
2
DISCUSSION
0
null
null
19,503,677
null
Moreover, the concept of preventing disabilities is emphasized not only in rehabilitation medicine, but also in CBR, indicating that disability evaluation needs another factor of support system based on their community.
null
219
38,036
0
false
null
null
Moreover, the concept of preventing disabilities is emphasized not only in rehabilitation medicine, but also in CBR, indicating that disability evaluation needs another factor of support system based on their community.
true
true
true
true
true
6,525
2
DISCUSSION
0
null
null
19,503,677
null
Thus, it is important to think about the disability evaluation according to the characteristics of age, impairment and assistive environment.
null
141
38,037
0
false
null
null
Thus, it is important to think about the disability evaluation according to the characteristics of age, impairment and assistive environment.
true
true
true
true
true
6,525
2
DISCUSSION
0
null
null
19,503,677
null
In the field of CBR, disability evaluation has recently become important for measuring the effects of rehabilitation treatment in medical insurance and decision of the grade of welfare service volume in Japan.
null
209
38,038
0
false
null
null
In the field of CBR, disability evaluation has recently become important for measuring the effects of rehabilitation treatment in medical insurance and decision of the grade of welfare service volume in Japan.
true
true
true
true
true
6,525
3
DISCUSSION
0
null
null
19,503,677
null
While the first and second groups have been historically well-established without any disagreement on the classifications of disability type, the third group concerning psychological disability has recently been questioned with respect to the visibly less apparent disabilities relating to cognition, memory, attention, ...
null
377
38,039
0
false
null
null
While the first and second groups have been historically well-established without any disagreement on the classifications of disability type, the third group concerning psychological disability has recently been questioned with respect to the visibly less apparent disabilities relating to cognition, memory, attention, ...
true
true
true
true
true
6,526
3
DISCUSSION
0
null
null
19,503,677
null
Although the new system to evaluate and support such a disability group is under development throughout the country, problems with classification continue to be debated.
null
169
38,040
0
false
null
null
Although the new system to evaluate and support such a disability group is under development throughout the country, problems with classification continue to be debated.
true
true
true
true
true
6,526
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B6", "B4", "B7" ]
18,003,655
pmid-15277680|pmid-15479734|pmid-15003273|pmid-15803138|pmid-2839775|pmid-2839690|pmid-15803138|pmid-11050335|pmid-14960583
Selective translation of messenger RNAs (mRNAs) has emerged as an important mechanism that regulates gene expression, particularly in response to various physiological and pathophysiological conditions that require rapid changes in gene expression profiles.
[ "1", "2", "3", "4", "5", "6", "4", "7" ]
257
38,041
0
false
Selective translation of messenger RNAs (mRNAs) has emerged as an important mechanism that regulates gene expression, particularly in response to various physiological and pathophysiological conditions that require rapid changes in gene expression profiles.
[]
Selective translation of messenger RNAs (mRNAs) has emerged as an important mechanism that regulates gene expression, particularly in response to various physiological and pathophysiological conditions that require rapid changes in gene expression profiles.
true
true
true
true
true
6,527
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B6", "B4", "B7" ]
18,003,655
pmid-15277680|pmid-15479734|pmid-15003273|pmid-15803138|pmid-2839775|pmid-2839690|pmid-15803138|pmid-11050335|pmid-14960583
mRNAs that employ selective translation utilize various regulatory elements, most often located within their 5′ untranslated regions (UTRs) that allow preferential translation.
[ "1", "2", "3", "4", "5", "6", "4", "7" ]
176
38,042
0
false
mRNAs that employ selective translation utilize various regulatory elements, most often located within their 5′ untranslated regions (UTRs) that allow preferential translation.
[]
mRNAs that employ selective translation utilize various regulatory elements, most often located within their 5′ untranslated regions (UTRs) that allow preferential translation.
false
true
true
true
false
6,527
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B6", "B4", "B7" ]
18,003,655
pmid-15277680|pmid-15479734|pmid-15003273|pmid-15803138|pmid-2839775|pmid-2839690|pmid-15803138|pmid-11050335|pmid-14960583
For example, the 5′ UTR of the transcription factor ATF4 contains two short upstream open reading frames that render translation of the ATF4 reading frame inefficient (1,2).
[ "1", "2", "3", "4", "5", "6", "4", "7" ]
173
38,043
0
false
For example, the 5′ UTR of the transcription factor ATF4 contains two short upstream open reading frames that render translation of the ATF4 reading frame inefficient.
[ "1,2" ]
For example, the 5′ UTR of the transcription factor ATF4 contains two short upstream open reading frames that render translation of the ATF4 reading frame inefficient.
true
true
true
true
true
6,527
0
INTRODUCTION
1
3
[ "B1", "B2", "B3", "B4", "B5", "B6", "B4", "B7" ]
18,003,655
pmid-15277680|pmid-15479734|pmid-15003273|pmid-15803138|pmid-2839775|pmid-2839690|pmid-15803138|pmid-11050335|pmid-14960583
However, translation of ATF4 is specifically increased under conditions of increased eIF2α phosphorylation, such as during endoplasmic reticulum (ER) stress and the unfolded protein response, although the rate of global protein synthesis is reduced (3).
[ "1", "2", "3", "4", "5", "6", "4", "7" ]
253
38,044
1
false
However, translation of ATF4 is specifically increased under conditions of increased eIF2α phosphorylation, such as during endoplasmic reticulum (ER) stress and the unfolded protein response, although the rate of global protein synthesis is reduced.
[ "3" ]
However, translation of ATF4 is specifically increased under conditions of increased eIF2α phosphorylation, such as during endoplasmic reticulum (ER) stress and the unfolded protein response, although the rate of global protein synthesis is reduced.
true
true
true
true
true
6,527
0
INTRODUCTION
1
4
[ "B1", "B2", "B3", "B4", "B5", "B6", "B4", "B7" ]
18,003,655
pmid-15277680|pmid-15479734|pmid-15003273|pmid-15803138|pmid-2839775|pmid-2839690|pmid-15803138|pmid-11050335|pmid-14960583
Another stress-induced mode of translation initiation takes advantage of internal ribosome entry site (IRES) elements located within 5′ UTRs that permit cap-independent translation (4).
[ "1", "2", "3", "4", "5", "6", "4", "7" ]
185
38,045
1
false
Another stress-induced mode of translation initiation takes advantage of internal ribosome entry site (IRES) elements located within 5′ UTRs that permit cap-independent translation.
[ "4" ]
Another stress-induced mode of translation initiation takes advantage of internal ribosome entry site (IRES) elements located within 5′ UTRs that permit cap-independent translation.
true
true
true
true
true
6,527
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B6", "B4", "B7" ]
18,003,655
pmid-15277680|pmid-15479734|pmid-15003273|pmid-15803138|pmid-2839775|pmid-2839690|pmid-15803138|pmid-11050335|pmid-14960583
IRES were originally discovered in picornaviruses, where they initiate translation of naturally uncapped viral RNAs (5,6).
[ "1", "2", "3", "4", "5", "6", "4", "7" ]
122
38,046
0
false
IRES were originally discovered in picornaviruses, where they initiate translation of naturally uncapped viral RNAs.
[ "5,6" ]
IRES were originally discovered in picornaviruses, where they initiate translation of naturally uncapped viral RNAs.
true
true
true
true
true
6,527
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B6", "B4", "B7" ]
18,003,655
pmid-15277680|pmid-15479734|pmid-15003273|pmid-15803138|pmid-2839775|pmid-2839690|pmid-15803138|pmid-11050335|pmid-14960583
Interestingly, cellular IRES are found largely in mRNAs that encode proteins with important roles in differentiation, cell growth and proliferation and the regulation of apoptosis, suggesting that the selective modulation of IRES-mediated translation is critical for the regulation of cell death and survival (4,7).
[ "1", "2", "3", "4", "5", "6", "4", "7" ]
315
38,047
0
false
Interestingly, cellular IRES are found largely in mRNAs that encode proteins with important roles in differentiation, cell growth and proliferation and the regulation of apoptosis, suggesting that the selective modulation of IRES-mediated translation is critical for the regulation of cell death and survival.
[ "4,7" ]
Interestingly, cellular IRES are found largely in mRNAs that encode proteins with important roles in differentiation, cell growth and proliferation and the regulation of apoptosis, suggesting that the selective modulation of IRES-mediated translation is critical for the regulation of cell death and survival.
true
true
true
true
true
6,527
1
INTRODUCTION
1
8
[ "B8", "B9", "B4", "B10 B11 B12 B13", "B14", "B15" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
The precise molecular mechanism of cellular IRES-mediated translation is not fully understood.
[ "8", "9", "4", "10–13", "14", "15" ]
94
38,048
0
false
The precise molecular mechanism of cellular IRES-mediated translation is not fully understood.
[]
The precise molecular mechanism of cellular IRES-mediated translation is not fully understood.
true
true
true
true
true
6,528
1
INTRODUCTION
1
8
[ "B8", "B9", "B4", "B10 B11 B12 B13", "B14", "B15" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
Several studies have shown that most, if not all, cellular IRES require various auxiliary proteins termed ITAFs (IRES trans-acting factors) for efficient IRES-mediated translation (8,9).
[ "8", "9", "4", "10–13", "14", "15" ]
186
38,049
0
false
Several studies have shown that most, if not all, cellular IRES require various auxiliary proteins termed ITAFs (IRES trans-acting factors) for efficient IRES-mediated translation.
[ "8,9" ]
Several studies have shown that most, if not all, cellular IRES require various auxiliary proteins termed ITAFs (IRES trans-acting factors) for efficient IRES-mediated translation.
true
true
true
true
true
6,528
1
INTRODUCTION
1
4
[ "B8", "B9", "B4", "B10 B11 B12 B13", "B14", "B15" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
While the requirement for ITAFs is not the same for all cellular IRES, it is generally believed that these factors may function as RNA chaperones that aid in the remodeling of proper IRES conformation and therefore allow access of the ribosome (4).
[ "8", "9", "4", "10–13", "14", "15" ]
248
38,050
1
false
While the requirement for ITAFs is not the same for all cellular IRES, it is generally believed that these factors may function as RNA chaperones that aid in the remodeling of proper IRES conformation and therefore allow access of the ribosome.
[ "4" ]
While the requirement for ITAFs is not the same for all cellular IRES, it is generally believed that these factors may function as RNA chaperones that aid in the remodeling of proper IRES conformation and therefore allow access of the ribosome.
true
true
true
true
true
6,528
1
INTRODUCTION
1
8
[ "B8", "B9", "B4", "B10 B11 B12 B13", "B14", "B15" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
Alternatively, ITAFs may also directly recruit the ribosome to an IRES through interaction with ribosomal subunits.
[ "8", "9", "4", "10–13", "14", "15" ]
115
38,051
0
false
Alternatively, ITAFs may also directly recruit the ribosome to an IRES through interaction with ribosomal subunits.
[]
Alternatively, ITAFs may also directly recruit the ribosome to an IRES through interaction with ribosomal subunits.
true
true
true
true
true
6,528
1
INTRODUCTION
1
8
[ "B8", "B9", "B4", "B10 B11 B12 B13", "B14", "B15" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
The requirement for canonical initiation factors in IRES-mediated translation is even less understood.
[ "8", "9", "4", "10–13", "14", "15" ]
102
38,052
0
false
The requirement for canonical initiation factors in IRES-mediated translation is even less understood.
[]
The requirement for canonical initiation factors in IRES-mediated translation is even less understood.
true
true
true
true
true
6,528
1
INTRODUCTION
1
8
[ "B8", "B9", "B4", "B10 B11 B12 B13", "B14", "B15" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
Several studies have suggested that members of the eIF4G family may be required for cellular IRES-mediated translation, in particular during conditions of cellular stress and compromised global protein synthesis.
[ "8", "9", "4", "10–13", "14", "15" ]
212
38,053
0
false
Several studies have suggested that members of the eIF4G family may be required for cellular IRES-mediated translation, in particular during conditions of cellular stress and compromised global protein synthesis.
[]
Several studies have suggested that members of the eIF4G family may be required for cellular IRES-mediated translation, in particular during conditions of cellular stress and compromised global protein synthesis.
true
true
true
true
true
6,528
1
INTRODUCTION
1
10–13
[ "B8", "B9", "B4", "B10 B11 B12 B13", "B14", "B15" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
It was shown that caspase-cleaved fragments of two family members, eIF4GI and DAP5/p97, can specifically enhance translation mediated by several cellular IRES, including those of Apaf-1, c-myc, HIAP2, XIAP and DAP5/p97 mRNAs (10–13).
[ "8", "9", "4", "10–13", "14", "15" ]
233
38,054
1
false
It was shown that caspase-cleaved fragments of two family members, eIF4GI and DAP5/p97, can specifically enhance translation mediated by several cellular IRES, including those of Apaf-1, c-myc, HIAP2, XIAP and DAP5/p97 mRNAs.
[ "10–13" ]
It was shown that caspase-cleaved fragments of two family members, eIF4GI and DAP5/p97, can specifically enhance translation mediated by several cellular IRES, including those of Apaf-1, c-myc, HIAP2, XIAP and DAP5/p97 mRNAs.
true
true
true
true
true
6,528
1
INTRODUCTION
1
14
[ "B8", "B9", "B4", "B10 B11 B12 B13", "B14", "B15" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
Furthermore, using a HeLa cell-free translation system, the full-length DAP5/p97 was shown to support translation mediated by the c-myc, HIAP2 and XIAP IRES elements in eIF4G-depleted extracts (14).
[ "8", "9", "4", "10–13", "14", "15" ]
198
38,055
1
false
Furthermore, using a HeLa cell-free translation system, the full-length DAP5/p97 was shown to support translation mediated by the c-myc, HIAP2 and XIAP IRES elements in eIF4G-depleted extracts.
[ "14" ]
Furthermore, using a HeLa cell-free translation system, the full-length DAP5/p97 was shown to support translation mediated by the c-myc, HIAP2 and XIAP IRES elements in eIF4G-depleted extracts.
true
true
true
true
true
6,528
1
INTRODUCTION
1
15
[ "B8", "B9", "B4", "B10 B11 B12 B13", "B14", "B15" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
More recently, DAP5/p97 was suggested to control cell proliferation by regulating the translation of cell cycle proteins such as p27Kip1 (15).
[ "8", "9", "4", "10–13", "14", "15" ]
142
38,056
1
false
More recently, DAP5/p97 was suggested to control cell proliferation by regulating the translation of cell cycle proteins such as p27Kip1.
[ "15" ]
More recently, DAP5/p97 was suggested to control cell proliferation by regulating the translation of cell cycle proteins such as p27Kip1.
true
true
true
true
true
6,528
2
INTRODUCTION
0
null
null
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
In this study, we have investigated the role of DAP5/p97 in modulating selective translation of IRES-containing mRNAs during ER stress.
null
135
38,057
0
false
null
null
In this study, we have investigated the role of DAP5/p97 in modulating selective translation of IRES-containing mRNAs during ER stress.
true
true
true
true
true
6,529
2
INTRODUCTION
0
null
null
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
We show that DAP5/p97 is necessary for specific activation of at least two cellular IRES elements during pharmacologically induced ER stress.
null
141
38,058
0
false
null
null
We show that DAP5/p97 is necessary for specific activation of at least two cellular IRES elements during pharmacologically induced ER stress.
true
true
true
true
true
6,529
2
INTRODUCTION
0
null
null
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
We find that expression of DAP5/p97 and an inhibitor of apoptosis protein HIAP2 are enhanced during ER stress; their mRNAs are selectively recruited to the polysomes via IRES elements located in their respective 5′ UTRs.
null
220
38,059
0
false
null
null
We find that expression of DAP5/p97 and an inhibitor of apoptosis protein HIAP2 are enhanced during ER stress; their mRNAs are selectively recruited to the polysomes via IRES elements located in their respective 5′ UTRs.
true
true
true
true
true
6,529
2
INTRODUCTION
0
null
null
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
We further find that this process is dependent on DAP5/p97, as reducing the levels of endogenous DAP5/p97 by RNA interference abrogated the IRES-mediated translation of both DAP5/p97 and HIAP2 during ER stress.
null
210
38,060
0
false
null
null
We further find that this process is dependent on DAP5/p97, as reducing the levels of endogenous DAP5/p97 by RNA interference abrogated the IRES-mediated translation of both DAP5/p97 and HIAP2 during ER stress.
true
true
true
true
true
6,529
2
INTRODUCTION
0
null
null
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
Moreover, we find that proteolytic cleavage of DAP5/p97 to the DAP5/p86 isoform is not required for the translational induction of DAP5/p97 during ER stress.
null
157
38,061
0
false
null
null
Moreover, we find that proteolytic cleavage of DAP5/p97 to the DAP5/p86 isoform is not required for the translational induction of DAP5/p97 during ER stress.
true
true
true
true
true
6,529
2
INTRODUCTION
0
null
null
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
Thus, a positive feedback loop exists in which ER stress results in elevated levels of DAP5/p97 that, in turn, activate translation of specific mRNAs such as HIAP2 and DAP5/p97 itself under conditions of reduced cap-dependent translation.
null
238
38,062
0
false
null
null
Thus, a positive feedback loop exists in which ER stress results in elevated levels of DAP5/p97 that, in turn, activate translation of specific mRNAs such as HIAP2 and DAP5/p97 itself under conditions of reduced cap-dependent translation.
true
true
true
true
true
6,529
0
DISCUSSION
1
11
[ "B11" ]
18,003,655
pmid-15277680|pmid-15479734|pmid-15003273|pmid-15803138|pmid-2839775|pmid-2839690|pmid-15803138|pmid-11050335|pmid-14960583
In this work, we demonstrate that a member of the eIF4G translation initiation factor family, DAP5/p97, is necessary for the specific activation of at least two cellular IRES elements during pharmacologically induced ER stress.
[ "11" ]
227
38,063
0
false
In this work, we demonstrate that a member of the eIF4G translation initiation factor family, DAP5/p97, is necessary for the specific activation of at least two cellular IRES elements during pharmacologically induced ER stress.
[]
In this work, we demonstrate that a member of the eIF4G translation initiation factor family, DAP5/p97, is necessary for the specific activation of at least two cellular IRES elements during pharmacologically induced ER stress.
true
true
true
true
true
6,530
0
DISCUSSION
1
11
[ "B11" ]
18,003,655
pmid-15277680|pmid-15479734|pmid-15003273|pmid-15803138|pmid-2839775|pmid-2839690|pmid-15803138|pmid-11050335|pmid-14960583
We find that DAP5/p97 and HIAP2 protein levels are enhanced during ER stress; their mRNAs are selectively recruited to the polysomes via IRES elements located within their respective 5′ UTRs.
[ "11" ]
191
38,064
0
false
We find that DAP5/p97 and HIAP2 protein levels are enhanced during ER stress; their mRNAs are selectively recruited to the polysomes via IRES elements located within their respective 5′ UTRs.
[]
We find that DAP5/p97 and HIAP2 protein levels are enhanced during ER stress; their mRNAs are selectively recruited to the polysomes via IRES elements located within their respective 5′ UTRs.
true
true
true
true
true
6,530
0
DISCUSSION
1
11
[ "B11" ]
18,003,655
pmid-15277680|pmid-15479734|pmid-15003273|pmid-15803138|pmid-2839775|pmid-2839690|pmid-15803138|pmid-11050335|pmid-14960583
We further find that this process is dependent on DAP5/p97, as reducing the levels of endogenous DAP5/p97 by RNA interference abrogated both the translation and IRES activity of DAP5/p97 and HIAP2 during ER stress.
[ "11" ]
214
38,065
0
false
We further find that this process is dependent on DAP5/p97, as reducing the levels of endogenous DAP5/p97 by RNA interference abrogated both the translation and IRES activity of DAP5/p97 and HIAP2 during ER stress.
[]
We further find that this process is dependent on DAP5/p97, as reducing the levels of endogenous DAP5/p97 by RNA interference abrogated both the translation and IRES activity of DAP5/p97 and HIAP2 during ER stress.
true
true
true
true
true
6,530
0
DISCUSSION
1
11
[ "B11" ]
18,003,655
pmid-15277680|pmid-15479734|pmid-15003273|pmid-15803138|pmid-2839775|pmid-2839690|pmid-15803138|pmid-11050335|pmid-14960583
Thus, in a positive feedback loop the triggering of ER stress results in elevated levels of DAP5/p97 that, in turn, activate translation of specific mRNAs such as HIAP2 and DAP5/p97 itself under conditions of reduced cap-dependent translation.
[ "11" ]
243
38,066
0
false
Thus, in a positive feedback loop the triggering of ER stress results in elevated levels of DAP5/p97 that, in turn, activate translation of specific mRNAs such as HIAP2 and DAP5/p97 itself under conditions of reduced cap-dependent translation.
[]
Thus, in a positive feedback loop the triggering of ER stress results in elevated levels of DAP5/p97 that, in turn, activate translation of specific mRNAs such as HIAP2 and DAP5/p97 itself under conditions of reduced cap-dependent translation.
true
true
true
true
true
6,530
0
DISCUSSION
1
11
[ "B11" ]
18,003,655
pmid-15277680|pmid-15479734|pmid-15003273|pmid-15803138|pmid-2839775|pmid-2839690|pmid-15803138|pmid-11050335|pmid-14960583
Moreover, while cleavage of p97 to the DAP5/p86 isoform is required for the induction of HIAP2 IRES activity during ER stress (11), the translational induction of DAP5/p97 during ER stress is mediated by DAP5/p97 itself in a caspase-independent manner.
[ "11" ]
252
38,067
1
false
Moreover, while cleavage of p97 to the DAP5/p86 isoform is required for the induction of HIAP2 IRES activity during ER stress, the translational induction of DAP5/p97 during ER stress is mediated by DAP5/p97 itself in a caspase-independent manner.
[ "11" ]
Moreover, while cleavage of p97 to the DAP5/p86 isoform is required for the induction of HIAP2 IRES activity during ER stress, the translational induction of DAP5/p97 during ER stress is mediated by DAP5/p97 itself in a caspase-independent manner.
true
true
true
true
true
6,530
0
DISCUSSION
1
11
[ "B11" ]
18,003,655
pmid-15277680|pmid-15479734|pmid-15003273|pmid-15803138|pmid-2839775|pmid-2839690|pmid-15803138|pmid-11050335|pmid-14960583
The pivotal role of DAP5/p97 is further strengthened by our observation that siRNA-mediated reduction of DAP5/p97 results in cell death.
[ "11" ]
136
38,068
0
false
The pivotal role of DAP5/p97 is further strengthened by our observation that siRNA-mediated reduction of DAP5/p97 results in cell death.
[]
The pivotal role of DAP5/p97 is further strengthened by our observation that siRNA-mediated reduction of DAP5/p97 results in cell death.
true
true
true
true
true
6,530
1
DISCUSSION
1
28
[ "B28", "B29", "B30", "B31", "B29", "B32", "B33", "B28", "B29", "B34", "B10 B11 B12 B13", "B4", "B7", "B11", "B31" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
DAP5/p97 was identified by several groups by virtue of its homology to eIF4G (28), as a target of the APOBEC-1 editing enzyme that is heavily edited in the liver (29) and in a functional screening assay to identify modulators of interferon γ-induced apoptosis (30).
[ "28", "29", "30", "31", "29", "32", "33", "28", "29", "34", "10–13", "4", "7", "11", "31" ]
265
38,069
1
false
DAP5/p97 was identified by several groups by virtue of its homology to eIF4G, as a target of the APOBEC-1 editing enzyme that is heavily edited in the liver and in a functional screening assay to identify modulators of interferon γ-induced apoptosis.
[ "28", "29", "30" ]
DAP5/p97 was identified by several groups by virtue of its homology to eIF4G, as a target of the APOBEC-1 editing enzyme that is heavily edited in the liver and in a functional screening assay to identify modulators of interferon γ-induced apoptosis.
true
true
true
true
true
6,531
1
DISCUSSION
1
31
[ "B28", "B29", "B30", "B31", "B29", "B32", "B33", "B28", "B29", "B34", "B10 B11 B12 B13", "B4", "B7", "B11", "B31" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
DAP5/p97 shares significant homology to eIF4G; however, this homology is restricted to the central and C-terminal portions of eIF4G (31).
[ "28", "29", "30", "31", "29", "32", "33", "28", "29", "34", "10–13", "4", "7", "11", "31" ]
137
38,070
1
false
DAP5/p97 shares significant homology to eIF4G; however, this homology is restricted to the central and C-terminal portions of eIF4G.
[ "31" ]
DAP5/p97 shares significant homology to eIF4G; however, this homology is restricted to the central and C-terminal portions of eIF4G.
true
true
true
true
true
6,531
1
DISCUSSION
1
28
[ "B28", "B29", "B30", "B31", "B29", "B32", "B33", "B28", "B29", "B34", "B10 B11 B12 B13", "B4", "B7", "B11", "B31" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
Like eIF4G, DAP5/p97 can interact with eIF3, eIF4A and Mnk-1 (29,32,33).
[ "28", "29", "30", "31", "29", "32", "33", "28", "29", "34", "10–13", "4", "7", "11", "31" ]
72
38,071
0
false
Like eIF4G, DAP5/p97 can interact with eIF3, eIF4A and Mnk-1.
[ "29,32,33" ]
Like eIF4G, DAP5/p97 can interact with eIF3, eIF4A and Mnk-1.
true
true
true
true
true
6,531
1
DISCUSSION
1
28
[ "B28", "B29", "B30", "B31", "B29", "B32", "B33", "B28", "B29", "B34", "B10 B11 B12 B13", "B4", "B7", "B11", "B31" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
Unlike eIF4G, however, DAP5/p97 lacks the amino-terminal portion that includes the eIF4E and PABP-binding domains.
[ "28", "29", "30", "31", "29", "32", "33", "28", "29", "34", "10–13", "4", "7", "11", "31" ]
114
38,072
0
false
Unlike eIF4G, however, DAP5/p97 lacks the amino-terminal portion that includes the eIF4E and PABP-binding domains.
[]
Unlike eIF4G, however, DAP5/p97 lacks the amino-terminal portion that includes the eIF4E and PABP-binding domains.
true
true
true
true
true
6,531
1
DISCUSSION
1
28
[ "B28", "B29", "B30", "B31", "B29", "B32", "B33", "B28", "B29", "B34", "B10 B11 B12 B13", "B4", "B7", "B11", "B31" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
Therefore, it is believed that DAP5/p97 cannot support cap-dependent translation initiation.
[ "28", "29", "30", "31", "29", "32", "33", "28", "29", "34", "10–13", "4", "7", "11", "31" ]
92
38,073
0
false
Therefore, it is believed that DAP5/p97 cannot support cap-dependent translation initiation.
[]
Therefore, it is believed that DAP5/p97 cannot support cap-dependent translation initiation.
true
true
true
true
true
6,531
1
DISCUSSION
1
28
[ "B28", "B29", "B30", "B31", "B29", "B32", "B33", "B28", "B29", "B34", "B10 B11 B12 B13", "B4", "B7", "B11", "B31" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
Consistent with this idea, overexpression of DAP5/p97 was found to repress both cap-dependent and EMCV IRES-dependent translation, presumably by sequestering eIF3 and eIF4A in inactive complexes (28,29).
[ "28", "29", "30", "31", "29", "32", "33", "28", "29", "34", "10–13", "4", "7", "11", "31" ]
203
38,074
0
false
Consistent with this idea, overexpression of DAP5/p97 was found to repress both cap-dependent and EMCV IRES-dependent translation, presumably by sequestering eIF3 and eIF4A in inactive complexes.
[ "28,29" ]
Consistent with this idea, overexpression of DAP5/p97 was found to repress both cap-dependent and EMCV IRES-dependent translation, presumably by sequestering eIF3 and eIF4A in inactive complexes.
true
true
true
true
true
6,531
1
DISCUSSION
1
34
[ "B28", "B29", "B30", "B31", "B29", "B32", "B33", "B28", "B29", "B34", "B10 B11 B12 B13", "B4", "B7", "B11", "B31" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
In contrast, however, DAP5/p97-null ES cells have normal levels of global protein synthesis and show no differences in the activities of several IRES (34).
[ "28", "29", "30", "31", "29", "32", "33", "28", "29", "34", "10–13", "4", "7", "11", "31" ]
155
38,075
1
false
In contrast, however, DAP5/p97-null ES cells have normal levels of global protein synthesis and show no differences in the activities of several IRES.
[ "34" ]
In contrast, however, DAP5/p97-null ES cells have normal levels of global protein synthesis and show no differences in the activities of several IRES.
true
true
true
true
true
6,531
1
DISCUSSION
1
10–13
[ "B28", "B29", "B30", "B31", "B29", "B32", "B33", "B28", "B29", "B34", "B10 B11 B12 B13", "B4", "B7", "B11", "B31" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
Furthermore, many studies have shown that the caspase-cleaved fragment of DAP5/p97 (termed DAP5/p86), but not the full-length DAP5/p97, is capable of specifically enhancing the translation mediated by the Apaf-1, c-myc, XIAP, and HIAP2 IRES elements (10–13).
[ "28", "29", "30", "31", "29", "32", "33", "28", "29", "34", "10–13", "4", "7", "11", "31" ]
258
38,076
1
false
Furthermore, many studies have shown that the caspase-cleaved fragment of DAP5/p97 (termed DAP5/p86), but not the full-length DAP5/p97, is capable of specifically enhancing the translation mediated by the Apaf-1, c-myc, XIAP, and HIAP2 IRES elements.
[ "10–13" ]
Furthermore, many studies have shown that the caspase-cleaved fragment of DAP5/p97 (termed DAP5/p86), but not the full-length DAP5/p97, is capable of specifically enhancing the translation mediated by the Apaf-1, c-myc, XIAP, and HIAP2 IRES elements.
true
true
true
true
true
6,531
1
DISCUSSION
1
28
[ "B28", "B29", "B30", "B31", "B29", "B32", "B33", "B28", "B29", "B34", "B10 B11 B12 B13", "B4", "B7", "B11", "B31" ]
18,003,655
pmid-15094769|pmid-15818406|pmid-15803138|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-16174738|pmid-16932749|pmid-9049310|pmid-9030685|pmid-9032289|NA|pmid-9030685|pmid-9372926|pmid-9878069|pmid-9049310|pmid-9030685|pmid-11032820|pmid-12458215|pmid-14960583|pmid-11943866|pmid-10611228|pmid-15803138|pmi...
Thus a model has emerged in which DAP5/p97 is activated by caspase cleavage and the resulting DAP5/p86 fragment functions as a specific translation initiation factor for cellular IRES, in particular during conditions of pathophysiological stress (4,7,11,31).
[ "28", "29", "30", "31", "29", "32", "33", "28", "29", "34", "10–13", "4", "7", "11", "31" ]
258
38,077
0
false
Thus a model has emerged in which DAP5/p97 is activated by caspase cleavage and the resulting DAP5/p86 fragment functions as a specific translation initiation factor for cellular IRES, in particular during conditions of pathophysiological stress.
[ "4,7,11,31" ]
Thus a model has emerged in which DAP5/p97 is activated by caspase cleavage and the resulting DAP5/p86 fragment functions as a specific translation initiation factor for cellular IRES, in particular during conditions of pathophysiological stress.
true
true
true
true
true
6,531
2
DISCUSSION
1
14
[ "B14", "B27", "B35", "B27", "B34", "B35", "B15", "B15", "B34" ]
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
However, several recent publications have challenged this model.
[ "14", "27", "35", "27", "34", "35", "15", "15", "34" ]
64
38,078
0
false
However, several recent publications have challenged this model.
[]
However, several recent publications have challenged this model.
true
true
true
true
true
6,532
2
DISCUSSION
1
14
[ "B14", "B27", "B35", "B27", "B34", "B35", "B15", "B15", "B34" ]
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
It was shown that the addition of exogenous DAP5/p97 can stimulate the activity of the XIAP, c-myc, DAP5/p97 and HIAP2 IRES elements in a HeLa-based cell-free translation system depleted of eIF4G (14).
[ "14", "27", "35", "27", "34", "35", "15", "15", "34" ]
201
38,079
1
false
It was shown that the addition of exogenous DAP5/p97 can stimulate the activity of the XIAP, c-myc, DAP5/p97 and HIAP2 IRES elements in a HeLa-based cell-free translation system depleted of eIF4G.
[ "14" ]
It was shown that the addition of exogenous DAP5/p97 can stimulate the activity of the XIAP, c-myc, DAP5/p97 and HIAP2 IRES elements in a HeLa-based cell-free translation system depleted of eIF4G.
true
true
true
true
true
6,532
2
DISCUSSION
1
14
[ "B14", "B27", "B35", "B27", "B34", "B35", "B15", "B15", "B34" ]
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
More recently, it was shown that DAP5/p97 can function as an activator of translation in vivo and this function of DAP5/p97 does not necessarily requires proteolytic processing (27,35).
[ "14", "27", "35", "27", "34", "35", "15", "15", "34" ]
185
38,080
0
false
More recently, it was shown that DAP5/p97 can function as an activator of translation in vivo and this function of DAP5/p97 does not necessarily requires proteolytic processing.
[ "27,35" ]
More recently, it was shown that DAP5/p97 can function as an activator of translation in vivo and this function of DAP5/p97 does not necessarily requires proteolytic processing.
true
true
true
true
true
6,532
2
DISCUSSION
1
14
[ "B14", "B27", "B35", "B27", "B34", "B35", "B15", "B15", "B34" ]
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
In these experiments, DAP5/p97 was found to be associated with polysomes, overexpression of DAP5/p97 resulted in the activation of cap-dependent reporter mRNA translation and global protein synthesis and siRNA-mediated knockdown of DAP5/p97 led to a reduction of global protein synthesis.
[ "14", "27", "35", "27", "34", "35", "15", "15", "34" ]
288
38,081
0
false
In these experiments, DAP5/p97 was found to be associated with polysomes, overexpression of DAP5/p97 resulted in the activation of cap-dependent reporter mRNA translation and global protein synthesis and siRNA-mediated knockdown of DAP5/p97 led to a reduction of global protein synthesis.
[]
In these experiments, DAP5/p97 was found to be associated with polysomes, overexpression of DAP5/p97 resulted in the activation of cap-dependent reporter mRNA translation and global protein synthesis and siRNA-mediated knockdown of DAP5/p97 led to a reduction of global protein synthesis.
true
true
true
true
true
6,532
2
DISCUSSION
1
14
[ "B14", "B27", "B35", "B27", "B34", "B35", "B15", "B15", "B34" ]
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
These observations are all consistent with the role of DAP5/p97 as an activator of translation.
[ "14", "27", "35", "27", "34", "35", "15", "15", "34" ]
95
38,082
0
false
These observations are all consistent with the role of DAP5/p97 as an activator of translation.
[]
These observations are all consistent with the role of DAP5/p97 as an activator of translation.
true
true
true
true
true
6,532
2
DISCUSSION
1
14
[ "B14", "B27", "B35", "B27", "B34", "B35", "B15", "B15", "B34" ]
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
In addition, reduced DAP5/p97 levels result in a reduction in cell viability and embryonic lethality in both zebrafish and mouse (27,34,35).
[ "14", "27", "35", "27", "34", "35", "15", "15", "34" ]
140
38,083
0
false
In addition, reduced DAP5/p97 levels result in a reduction in cell viability and embryonic lethality in both zebrafish and mouse.
[ "27,34,35" ]
In addition, reduced DAP5/p97 levels result in a reduction in cell viability and embryonic lethality in both zebrafish and mouse.
true
true
true
true
true
6,532
2
DISCUSSION
1
14
[ "B14", "B27", "B35", "B27", "B34", "B35", "B15", "B15", "B34" ]
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
Our data confirm the observation that DAP5/p97 knockdown is not compatible with cell survival.
[ "14", "27", "35", "27", "34", "35", "15", "15", "34" ]
94
38,084
0
false
Our data confirm the observation that DAP5/p97 knockdown is not compatible with cell survival.
[]
Our data confirm the observation that DAP5/p97 knockdown is not compatible with cell survival.
true
true
true
true
true
6,532
2
DISCUSSION
1
15
[ "B14", "B27", "B35", "B27", "B34", "B35", "B15", "B15", "B34" ]
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
However, in contrast to the data of Lee and McCormick (15), we find that a reduction in DAP5/p97 levels does not affect global protein synthesis (Figure 4A).
[ "14", "27", "35", "27", "34", "35", "15", "15", "34" ]
157
38,085
1
false
However, in contrast to the data of Lee and McCormick, we find that a reduction in DAP5/p97 levels does not affect global protein synthesis (Figure 4A).
[ "15" ]
However, in contrast to the data of Lee and McCormick, we find that a reduction in DAP5/p97 levels does not affect global protein synthesis (Figure 4A).
true
true
true
true
true
6,532
2
DISCUSSION
1
14
[ "B14", "B27", "B35", "B27", "B34", "B35", "B15", "B15", "B34" ]
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
The likely explanation for this discrepancy is that, while Lee and McCormick assessed protein synthesis 48 h post-
[ "14", "27", "35", "27", "34", "35", "15", "15", "34" ]
114
38,086
0
false
The likely explanation for this discrepancy is that, while Lee and McCormick assessed protein synthesis 48 h post-
[]
The likely explanation for this discrepancy is that, while Lee and McCormick assessed protein synthesis 48 h post-
true
true
false
true
false
6,532
2
DISCUSSION
1
14
[ "B14", "B27", "B35", "B27", "B34", "B35", "B15", "B15", "B34" ]
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
DAP5/p97 knockdown, in our experiments polysome profiling was performed 24 h after siRNA treatment because we observed a significant loss of cell viability after this timepoint.
[ "14", "27", "35", "27", "34", "35", "15", "15", "34" ]
177
38,087
0
false
DAP5/p97 knockdown, in our experiments polysome profiling was performed 24 h after siRNA treatment because we observed a significant loss of cell viability after this timepoint.
[]
DAP5/p97 knockdown, in our experiments polysome profiling was performed 24 h after siRNA treatment because we observed a significant loss of cell viability after this timepoint.
true
true
true
true
true
6,532
2
DISCUSSION
1
14
[ "B14", "B27", "B35", "B27", "B34", "B35", "B15", "B15", "B34" ]
18,003,655
pmid-16174738|NA|NA|NA|pmid-11032820|NA|pmid-16932749|pmid-16932749|pmid-11032820
It should also be noted that DAP5/p97-null ES cells do not display a defect in global protein synthesis (15,34) suggesting that the role of DAP5/97 in the regulation of global translation may be cell-type specific.
[ "14", "27", "35", "27", "34", "35", "15", "15", "34" ]
214
38,088
0
false
It should also be noted that DAP5/p97-null ES cells do not display a defect in global protein synthesis suggesting that the role of DAP5/97 in the regulation of global translation may be cell-type specific.
[ "15,34" ]
It should also be noted that DAP5/p97-null ES cells do not display a defect in global protein synthesis suggesting that the role of DAP5/97 in the regulation of global translation may be cell-type specific.
true
true
true
true
true
6,532
3
DISCUSSION
1
10–12
[ "B10 B11 B12", "B11", "B36", "B27" ]
18,003,655
pmid-12458215|pmid-14960583|pmid-11943866|pmid-14960583|pmid-15302935|NA
We and others have shown previously that overexpression of the p86 fragment of DAP5/p97 is sufficient to activate the DAP5/p97 and HIAP2 IRES elements (10–12).
[ "10–12", "11", "36", "27" ]
159
38,089
1
false
We and others have shown previously that overexpression of the p86 fragment of DAP5/p97 is sufficient to activate the DAP5/p97 and HIAP2 IRES elements.
[ "10–12" ]
We and others have shown previously that overexpression of the p86 fragment of DAP5/p97 is sufficient to activate the DAP5/p97 and HIAP2 IRES elements.
true
true
true
true
true
6,533
3
DISCUSSION
1
10–12
[ "B10 B11 B12", "B11", "B36", "B27" ]
18,003,655
pmid-12458215|pmid-14960583|pmid-11943866|pmid-14960583|pmid-15302935|NA
Here we have extended these observations by demonstrating that both DAP5/p97 and HIAP2 IRES-mediated translation are dependent on DAP5/p97, since the knockdown of p97 significantly reduces translation of DAP5/p97 itself and HIAP2 during ER stress by precluding activation of their respective IRES elements.
[ "10–12", "11", "36", "27" ]
306
38,090
0
false
Here we have extended these observations by demonstrating that both DAP5/p97 and HIAP2 IRES-mediated translation are dependent on DAP5/p97, since the knockdown of p97 significantly reduces translation of DAP5/p97 itself and HIAP2 during ER stress by precluding activation of their respective IRES elements.
[]
Here we have extended these observations by demonstrating that both DAP5/p97 and HIAP2 IRES-mediated translation are dependent on DAP5/p97, since the knockdown of p97 significantly reduces translation of DAP5/p97 itself and HIAP2 during ER stress by precluding activation of their respective IRES elements.
true
true
true
true
true
6,533
3
DISCUSSION
1
11
[ "B10 B11 B12", "B11", "B36", "B27" ]
18,003,655
pmid-12458215|pmid-14960583|pmid-11943866|pmid-14960583|pmid-15302935|NA
However, in contrast to the requirement of caspase-mediated cleavage of DAP5/p97 to the p86 isoform for induction of HIAP2 IRES activity (11), we find that the translational induction of DAP5/p97 following ER stress does not require caspase activity.
[ "10–12", "11", "36", "27" ]
250
38,091
1
false
However, in contrast to the requirement of caspase-mediated cleavage of DAP5/p97 to the p86 isoform for induction of HIAP2 IRES activity, we find that the translational induction of DAP5/p97 following ER stress does not require caspase activity.
[ "11" ]
However, in contrast to the requirement of caspase-mediated cleavage of DAP5/p97 to the p86 isoform for induction of HIAP2 IRES activity, we find that the translational induction of DAP5/p97 following ER stress does not require caspase activity.
true
true
true
true
true
6,533
3
DISCUSSION
1
10–12
[ "B10 B11 B12", "B11", "B36", "B27" ]
18,003,655
pmid-12458215|pmid-14960583|pmid-11943866|pmid-14960583|pmid-15302935|NA
Since DAP5/p97 is absolutely required for the translational induction of DAP5/p97 during ER stress, we conclude that DAP5/p97 enhances the activity of its IRES in a caspase-independent manner.
[ "10–12", "11", "36", "27" ]
192
38,092
0
false
Since DAP5/p97 is absolutely required for the translational induction of DAP5/p97 during ER stress, we conclude that DAP5/p97 enhances the activity of its IRES in a caspase-independent manner.
[]
Since DAP5/p97 is absolutely required for the translational induction of DAP5/p97 during ER stress, we conclude that DAP5/p97 enhances the activity of its IRES in a caspase-independent manner.
true
true
true
true
true
6,533
3
DISCUSSION
1
10–12
[ "B10 B11 B12", "B11", "B36", "B27" ]
18,003,655
pmid-12458215|pmid-14960583|pmid-11943866|pmid-14960583|pmid-15302935|NA
These data support the hypothesis that DAP5/p97 can function as a translational activator in the absence of proteolytic processing.
[ "10–12", "11", "36", "27" ]
131
38,093
0
false
These data support the hypothesis that DAP5/p97 can function as a translational activator in the absence of proteolytic processing.
[]
These data support the hypothesis that DAP5/p97 can function as a translational activator in the absence of proteolytic processing.
true
true
true
true
true
6,533
3
DISCUSSION
1
10–12
[ "B10 B11 B12", "B11", "B36", "B27" ]
18,003,655
pmid-12458215|pmid-14960583|pmid-11943866|pmid-14960583|pmid-15302935|NA
It is possible that other post-translational modifications of DAP5/p97 during ER stress control its ability to modulate IRES activity.
[ "10–12", "11", "36", "27" ]
134
38,094
0
false
It is possible that other post-translational modifications of DAP5/p97 during ER stress control its ability to modulate IRES activity.
[]
It is possible that other post-translational modifications of DAP5/p97 during ER stress control its ability to modulate IRES activity.
true
true
true
true
true
6,533
3
DISCUSSION
1
36
[ "B10 B11 B12", "B11", "B36", "B27" ]
18,003,655
pmid-12458215|pmid-14960583|pmid-11943866|pmid-14960583|pmid-15302935|NA
Indeed, phosphorylation of DAP5/p97 at threonine 508 was identified by a large-scale proteomics study (36) and it has been suggested that phosphorylation of DAP5/p97 controls its activity in response to growth factor signaling (27).
[ "10–12", "11", "36", "27" ]
232
38,095
1
false
Indeed, phosphorylation of DAP5/p97 at threonine 508 was identified by a large-scale proteomics study and it has been suggested that phosphorylation of DAP5/p97 controls its activity in response to growth factor signaling.
[ "36", "27" ]
Indeed, phosphorylation of DAP5/p97 at threonine 508 was identified by a large-scale proteomics study and it has been suggested that phosphorylation of DAP5/p97 controls its activity in response to growth factor signaling.
true
true
true
true
true
6,533
3
DISCUSSION
1
10–12
[ "B10 B11 B12", "B11", "B36", "B27" ]
18,003,655
pmid-12458215|pmid-14960583|pmid-11943866|pmid-14960583|pmid-15302935|NA
Further investigations of the signaling pathways that modulate DAP5/p97 activity during cellular stress or following growth factor stimulation should prove to be enlightening.
[ "10–12", "11", "36", "27" ]
175
38,096
0
false
Further investigations of the signaling pathways that modulate DAP5/p97 activity during cellular stress or following growth factor stimulation should prove to be enlightening.
[]
Further investigations of the signaling pathways that modulate DAP5/p97 activity during cellular stress or following growth factor stimulation should prove to be enlightening.
true
true
true
true
true
6,533
4
DISCUSSION
0
null
null
18,003,655
null
We sought to mechanistically determine how full-length DAP5/p97 differentiates between distinct mRNA molecules such as DAP5/p97 and HIAP2.
null
138
38,097
0
false
null
null
We sought to mechanistically determine how full-length DAP5/p97 differentiates between distinct mRNA molecules such as DAP5/p97 and HIAP2.
true
true
true
true
true
6,534
4
DISCUSSION
0
null
null
18,003,655
null
Our data indicate that both full-length DAP5/p97 and the truncated p86 fragment are capable of binding DAP5/p97 and HIAP2 endogenous mRNAs equally well.
null
152
38,098
0
false
null
null
Our data indicate that both full-length DAP5/p97 and the truncated p86 fragment are capable of binding DAP5/p97 and HIAP2 endogenous mRNAs equally well.
true
true
true
true
true
6,534
4
DISCUSSION
0
null
null
18,003,655
null
Thus, the simple model whereby DAP5/p97 associates with a particular pool of cellular mRNAs while its DAP5/p86 truncated isoform associates with a different cohort of mRNAs is unlikely.
null
185
38,099
0
false
null
null
Thus, the simple model whereby DAP5/p97 associates with a particular pool of cellular mRNAs while its DAP5/p86 truncated isoform associates with a different cohort of mRNAs is unlikely.
true
true
true
true
true
6,534
4
DISCUSSION
0
null
null
18,003,655
null
Our observations raise the possibility that full-length DAP5/p97 preassembles with several mRNAs, but is only able to enhance IRES-dependent translation following a particular post-translational modification, which may be different depending on the target mRNA molecule.
null
270
38,100
0
false
null
null
Our observations raise the possibility that full-length DAP5/p97 preassembles with several mRNAs, but is only able to enhance IRES-dependent translation following a particular post-translational modification, which may be different depending on the target mRNA molecule.
true
true
true
true
true
6,534
4
DISCUSSION
0
null
null
18,003,655
null
For example, caspase cleavage of DAP5/p97 to generate the DAP5/p86 isoform enhances both DAP5/p97 and HIAP2 IRES activity, whereas other post-translational modifications (such as phosphorylation) may be sufficient to allow full-length DAP5/p97 to enhance the activity of its own IRES.
null
284
38,101
0
false
null
null
For example, caspase cleavage of DAP5/p97 to generate the DAP5/p86 isoform enhances both DAP5/p97 and HIAP2 IRES activity, whereas other post-translational modifications (such as phosphorylation) may be sufficient to allow full-length DAP5/p97 to enhance the activity of its own IRES.
true
true
true
true
true
6,534
5
DISCUSSION
1
35
[ "B35" ]
18,003,655
NA
In summary, our data provide direct evidence that DAP5/p97 can function as a translational activator of at least two IRES-containing cellular mRNAs during conditions of pathophysiological stress.
[ "35" ]
195
38,102
0
false
In summary, our data provide direct evidence that DAP5/p97 can function as a translational activator of at least two IRES-containing cellular mRNAs during conditions of pathophysiological stress.
[]
In summary, our data provide direct evidence that DAP5/p97 can function as a translational activator of at least two IRES-containing cellular mRNAs during conditions of pathophysiological stress.
true
true
true
true
true
6,535
5
DISCUSSION
1
35
[ "B35" ]
18,003,655
NA
Together with previously published observations (35), these findings support the hypothesis that DAP5/p97 controls translation of select, rather than all, mRNAs.
[ "35" ]
161
38,103
1
false
Together with previously published observations, these findings support the hypothesis that DAP5/p97 controls translation of select, rather than all, mRNAs.
[ "35" ]
Together with previously published observations, these findings support the hypothesis that DAP5/p97 controls translation of select, rather than all, mRNAs.
true
true
true
true
true
6,535
5
DISCUSSION
1
35
[ "B35" ]
18,003,655
NA
Importantly, the fact that the DAP5/p97 IRES itself is activated by DAP5/p97 during ER stress suggests the existence of a positive feedback loop that ensures elevated levels of DAP5/p97 to support IRES-dependent translation of select mRNAs during conditions of reduced global protein synthesis.
[ "35" ]
294
38,104
0
false
Importantly, the fact that the DAP5/p97 IRES itself is activated by DAP5/p97 during ER stress suggests the existence of a positive feedback loop that ensures elevated levels of DAP5/p97 to support IRES-dependent translation of select mRNAs during conditions of reduced global protein synthesis.
[]
Importantly, the fact that the DAP5/p97 IRES itself is activated by DAP5/p97 during ER stress suggests the existence of a positive feedback loop that ensures elevated levels of DAP5/p97 to support IRES-dependent translation of select mRNAs during conditions of reduced global protein synthesis.
true
true
true
true
true
6,535
0
INTRODUCTION
1
1
[ "B1", "B3", "B4" ]
17,066,524
pmid-4020086|pmid-1778144|pmid-2919305|pmid-4020086|pmid-4020086|pmid-11693342|pmid-11693342|pmid-4020086
Hamartomatous polyps of the colon are rare in adults, and nearly all cases are associated with hereditary or familial polyposis syndromes.1-3 Colonic hamartomas are non-neoplastic lesions1, and these mucosal protuberances contain mesenchymal elements of excess vascular and/or fibrous stroma and glandular proliferation ...
[ "1", "3", "4" ]
343
38,105
0
false
Hamartomatous polyps of the colon are rare in adults, and nearly all cases are associated with hereditary or familial polyposis syndromes.1-3 Colonic hamartomas are non-neoplastic lesions1, and these mucosal protuberances contain mesenchymal elements of excess vascular and/or fibrous stroma and glandular proliferation ...
[]
Hamartomatous polyps of the colon are rare in adults, and nearly all cases are associated with hereditary or familial polyposis syndromes.1-3 Colonic hamartomas are non-neoplastic lesions1, and these mucosal protuberances contain mesenchymal elements of excess vascular and/or fibrous stroma and glandular proliferation ...
true
true
true
true
true
6,536
0
INTRODUCTION
1
1
[ "B1", "B3", "B4" ]
17,066,524
pmid-4020086|pmid-1778144|pmid-2919305|pmid-4020086|pmid-4020086|pmid-11693342|pmid-11693342|pmid-4020086
Mesenchymal proliferation disorders are heterogeneous, and excessive growth may be a post-natal indication of an underlying developmental abnormality.4
[ "1", "3", "4" ]
151
38,106
0
false
Mesenchymal proliferation disorders are heterogeneous, and excessive growth may be a post-natal indication of an underlying developmental abnormality.4
[]
Mesenchymal proliferation disorders are heterogeneous, and excessive growth may be a post-natal indication of an underlying developmental abnormality.4
true
true
false
true
false
6,536
1
INTRODUCTION
0
null
null
17,066,524
pmid-4317531
Here, we report an unusual case of a giant colonic hamartoma in a 48-year-old man that is not associated with other hereditary or familial polyposis syndromes.
null
159
38,107
0
false
null
null
Here, we report an unusual case of a giant colonic hamartoma in a 48-year-old man that is not associated with other hereditary or familial polyposis syndromes.
true
true
true
true
true
6,537
0
DISCUSSION
1
1
[ "B1", "B1", "B2", "B2", "B1" ]
17,066,524
pmid-4020086|pmid-1778144|pmid-2919305|pmid-4020086|pmid-4020086|pmid-11693342|pmid-11693342|pmid-4020086
Colonic hamartomas, or juvenile polyps, are acquired lesions most commonly found in individuals between 1 and 7 years of age.
[ "1", "1", "2", "2", "1" ]
125
38,108
0
false
Colonic hamartomas, or juvenile polyps, are acquired lesions most commonly found in individuals between 1 and 7 years of age.
[]
Colonic hamartomas, or juvenile polyps, are acquired lesions most commonly found in individuals between 1 and 7 years of age.
true
true
true
true
true
6,538
0
DISCUSSION
1
1
[ "B1", "B1", "B2", "B2", "B1" ]
17,066,524
pmid-4020086|pmid-1778144|pmid-2919305|pmid-4020086|pmid-4020086|pmid-11693342|pmid-11693342|pmid-4020086
The lesions are usually associated with hereditary or familial polyposis syndromes.
[ "1", "1", "2", "2", "1" ]
83
38,109
0
false
The lesions are usually associated with hereditary or familial polyposis syndromes.
[]
The lesions are usually associated with hereditary or familial polyposis syndromes.
true
true
true
true
true
6,538
0
DISCUSSION
1
1
[ "B1", "B1", "B2", "B2", "B1" ]
17,066,524
pmid-4020086|pmid-1778144|pmid-2919305|pmid-4020086|pmid-4020086|pmid-11693342|pmid-11693342|pmid-4020086
These colonic polyps are usually less than 4 cm in size, although larger polyps have been found.1 A MEDLINE search from 1966 to 2003 using hamartoma, colonic polyp, and giant hamartoma as search items was performed.
[ "1", "1", "2", "2", "1" ]
215
38,110
0
false
These colonic polyps are usually less than 4 cm in size, although larger polyps have been found.1 A MEDLINE search from 1966 to 2003 using hamartoma, colonic polyp, and giant hamartoma as search items was performed.
[]
These colonic polyps are usually less than 4 cm in size, although larger polyps have been found.1 A MEDLINE search from 1966 to 2003 using hamartoma, colonic polyp, and giant hamartoma as search items was performed.
true
true
true
true
true
6,538
0
DISCUSSION
1
1
[ "B1", "B1", "B2", "B2", "B1" ]
17,066,524
pmid-4020086|pmid-1778144|pmid-2919305|pmid-4020086|pmid-4020086|pmid-11693342|pmid-11693342|pmid-4020086
After excluding hereditary and familial polyposis syndromes, only three relevant articles were found in English language journals.
[ "1", "1", "2", "2", "1" ]
130
38,111
0
false
After excluding hereditary and familial polyposis syndromes, only three relevant articles were found in English language journals.
[]
After excluding hereditary and familial polyposis syndromes, only three relevant articles were found in English language journals.
true
true
true
true
true
6,538
0
DISCUSSION
1
1
[ "B1", "B1", "B2", "B2", "B1" ]
17,066,524
pmid-4020086|pmid-1778144|pmid-2919305|pmid-4020086|pmid-4020086|pmid-11693342|pmid-11693342|pmid-4020086
Colonic hamartoma, particularly of a large size and without mucocutaneous lesions, is rare and has been reported only twice.1,2 One report involved a 50-year-old man with ulcerative colitis.
[ "1", "1", "2", "2", "1" ]
190
38,112
0
false
Colonic hamartoma, particularly of a large size and without mucocutaneous lesions, is rare and has been reported only twice.1,2 One report involved a 50-year-old man with ulcerative colitis.
[]
Colonic hamartoma, particularly of a large size and without mucocutaneous lesions, is rare and has been reported only twice.1,2 One report involved a 50-year-old man with ulcerative colitis.
true
true
true
true
true
6,538
0
DISCUSSION
1
1
[ "B1", "B1", "B2", "B2", "B1" ]
17,066,524
pmid-4020086|pmid-1778144|pmid-2919305|pmid-4020086|pmid-4020086|pmid-11693342|pmid-11693342|pmid-4020086
In this case, the lesion was located in the ascending colon and was approximately 5 cm in length.
[ "1", "1", "2", "2", "1" ]
97
38,113
0
false
In this case, the lesion was located in the ascending colon and was approximately 5 cm in length.
[]
In this case, the lesion was located in the ascending colon and was approximately 5 cm in length.
true
true
true
true
true
6,538
0
DISCUSSION
1
1
[ "B1", "B1", "B2", "B2", "B1" ]
17,066,524
pmid-4020086|pmid-1778144|pmid-2919305|pmid-4020086|pmid-4020086|pmid-11693342|pmid-11693342|pmid-4020086
Resection was performed, because the large polypoid mass could not be distinguished from a possibly malignant mass.2 The other case involved a 26-year-old man with multiple large bowel polyps and a single immense colonic Peutz-Jeghers polyp.1 An endoscopic biopsy showed this to be an inflammatory polyp.
[ "1", "1", "2", "2", "1" ]
304
38,114
0
false
Resection was performed, because the large polypoid mass could not be distinguished from a possibly malignant mass.2 The other case involved a 26-year-old man with multiple large bowel polyps and a single immense colonic Peutz-Jeghers polyp.1 An endoscopic biopsy showed this to be an inflammatory polyp.
[]
Resection was performed, because the large polypoid mass could not be distinguished from a possibly malignant mass.2 The other case involved a 26-year-old man with multiple large bowel polyps and a single immense colonic Peutz-Jeghers polyp.1 An endoscopic biopsy showed this to be an inflammatory polyp.
true
true
true
true
true
6,538
0
DISCUSSION
1
1
[ "B1", "B1", "B2", "B2", "B1" ]
17,066,524
pmid-4020086|pmid-1778144|pmid-2919305|pmid-4020086|pmid-4020086|pmid-11693342|pmid-11693342|pmid-4020086
The lesion was postoperatively diagnosed as a hamartoma.
[ "1", "1", "2", "2", "1" ]
56
38,115
0
false
The lesion was postoperatively diagnosed as a hamartoma.
[]
The lesion was postoperatively diagnosed as a hamartoma.
true
true
true
true
true
6,538