Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
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1
DISCUSSION
1
1
[ "R1", "R22", "R3", "R22", "R3", "R22", "R12", "R13", "R22" ]
19,793,537
pmid-10985803|pmid-12396356|pmid-17997603|pmid-15280485|pmid-3232319|pmid-1827578|pmid-3015104|pmid-3685630|pmid-19156578|pmid-18483939|pmid-17296157|pmid-18483939|pmid-17296157|pmid-18483939|pmid-14742263|NA|pmid-18483939
In an uncomplicated IBV-infected chick, clinical signs such as gasping, coughing, tracheal rales and nasal discharge persist for only 5-to-7 days and disappear within 2 weeks
[ "1", "22", "3", "22", "3", "22", "12", "13", "22" ]
174
39,016
0
false
In an uncomplicated IBV-infected chick, clinical signs such as gasping, coughing, tracheal rales and nasal discharge persist for only 5-to-7 days and disappear within 2 weeks
[]
In an uncomplicated IBV-infected chick, clinical signs such as gasping, coughing, tracheal rales and nasal discharge persist for only 5-to-7 days and disappear within 2 weeks
true
true
false
true
false
6,717
1
DISCUSSION
1
1
[ "R1", "R22", "R3", "R22", "R3", "R22", "R12", "R13", "R22" ]
19,793,537
pmid-10985803|pmid-12396356|pmid-17997603|pmid-15280485|pmid-3232319|pmid-1827578|pmid-3015104|pmid-3685630|pmid-19156578|pmid-18483939|pmid-17296157|pmid-18483939|pmid-17296157|pmid-18483939|pmid-14742263|NA|pmid-18483939
In the recovery stage, unaffected basal cells may be responsible for epithelial hyperplasia after desquamation of the ciliated and goblet cells and reconstruction of the epithelium of the injured respiratory tract to reestablish normal physiological functioning [12, 13, 22].
[ "1", "22", "3", "22", "3", "22", "12", "13", "22" ]
275
39,017
0
false
In the recovery stage, unaffected basal cells may be responsible for epithelial hyperplasia after desquamation of the ciliated and goblet cells and reconstruction of the epithelium of the injured respiratory tract to reestablish normal physiological functioning.
[ "12, 13, 22" ]
In the recovery stage, unaffected basal cells may be responsible for epithelial hyperplasia after desquamation of the ciliated and goblet cells and reconstruction of the epithelium of the injured respiratory tract to reestablish normal physiological functioning.
true
true
true
true
true
6,717
1
DISCUSSION
1
1
[ "R1", "R22", "R3", "R22", "R3", "R22", "R12", "R13", "R22" ]
19,793,537
pmid-10985803|pmid-12396356|pmid-17997603|pmid-15280485|pmid-3232319|pmid-1827578|pmid-3015104|pmid-3685630|pmid-19156578|pmid-18483939|pmid-17296157|pmid-18483939|pmid-17296157|pmid-18483939|pmid-14742263|NA|pmid-18483939
The insensitivity of basal cells to IBV infection also suggests that coinfection with other viral or bacterial pathogens is required to disrupt basal membrane integrity and cause hemorrhage in IBV-infected tracheas.
[ "1", "22", "3", "22", "3", "22", "12", "13", "22" ]
215
39,018
0
false
The insensitivity of basal cells to IBV infection also suggests that coinfection with other viral or bacterial pathogens is required to disrupt basal membrane integrity and cause hemorrhage in IBV-infected tracheas.
[]
The insensitivity of basal cells to IBV infection also suggests that coinfection with other viral or bacterial pathogens is required to disrupt basal membrane integrity and cause hemorrhage in IBV-infected tracheas.
true
true
true
true
true
6,717
2
DISCUSSION
1
3
[ "R3", "R22", "R21", "R2", "R22" ]
19,793,537
pmid-10366560|pmid-8116258|pmid-9060710|pmid-9101471|pmid-4565461|pmid-7609057|pmid-15332284|pmid-10366560|pmid-9060710|pmid-17296157|pmid-18483939|pmid-18645889|pmid-2545316|pmid-18483939
At present, quantification of the virulence of IBV is still a problem [3, 22].
[ "3", "22", "21", "2", "22" ]
78
39,019
0
false
At present, quantification of the virulence of IBV is still a problem.
[ "3, 22" ]
At present, quantification of the virulence of IBV is still a problem.
true
true
true
true
true
6,718
2
DISCUSSION
1
21
[ "R3", "R22", "R21", "R2", "R22" ]
19,793,537
pmid-10366560|pmid-8116258|pmid-9060710|pmid-9101471|pmid-4565461|pmid-7609057|pmid-15332284|pmid-10366560|pmid-9060710|pmid-17296157|pmid-18483939|pmid-18645889|pmid-2545316|pmid-18483939
Measuring ciliostasis in TOC is not a sensitive approach for determining the severity of respiratory tract injury caused by IBV infection [21].
[ "3", "22", "21", "2", "22" ]
143
39,020
1
false
Measuring ciliostasis in TOC is not a sensitive approach for determining the severity of respiratory tract injury caused by IBV infection.
[ "21" ]
Measuring ciliostasis in TOC is not a sensitive approach for determining the severity of respiratory tract injury caused by IBV infection.
true
true
true
true
true
6,718
2
DISCUSSION
1
3
[ "R3", "R22", "R21", "R2", "R22" ]
19,793,537
pmid-10366560|pmid-8116258|pmid-9060710|pmid-9101471|pmid-4565461|pmid-7609057|pmid-15332284|pmid-10366560|pmid-9060710|pmid-17296157|pmid-18483939|pmid-18645889|pmid-2545316|pmid-18483939
In addition, different species of chicken may also vary in the vulnerability of their respiratory tissue to IBV infection [2, 22].
[ "3", "22", "21", "2", "22" ]
130
39,021
0
false
In addition, different species of chicken may also vary in the vulnerability of their respiratory tissue to IBV infection.
[ "2, 22" ]
In addition, different species of chicken may also vary in the vulnerability of their respiratory tissue to IBV infection.
true
true
true
true
true
6,718
2
DISCUSSION
1
3
[ "R3", "R22", "R21", "R2", "R22" ]
19,793,537
pmid-10366560|pmid-8116258|pmid-9060710|pmid-9101471|pmid-4565461|pmid-7609057|pmid-15332284|pmid-10366560|pmid-9060710|pmid-17296157|pmid-18483939|pmid-18645889|pmid-2545316|pmid-18483939
In our ATE system, IBV shows high affinity for ciliated cells and goblet cells.
[ "3", "22", "21", "2", "22" ]
79
39,022
0
false
In our ATE system, IBV shows high affinity for ciliated cells and goblet cells.
[]
In our ATE system, IBV shows high affinity for ciliated cells and goblet cells.
true
true
true
true
true
6,718
2
DISCUSSION
1
3
[ "R3", "R22", "R21", "R2", "R22" ]
19,793,537
pmid-10366560|pmid-8116258|pmid-9060710|pmid-9101471|pmid-4565461|pmid-7609057|pmid-15332284|pmid-10366560|pmid-9060710|pmid-17296157|pmid-18483939|pmid-18645889|pmid-2545316|pmid-18483939
Cell tropism, viral replication and viral spread can be determined and quantified by immunocytostaining, suggesting that ATE cells could serve as a quantitative platform to determine the pathogenesis of IBV.
[ "3", "22", "21", "2", "22" ]
207
39,023
0
false
Cell tropism, viral replication and viral spread can be determined and quantified by immunocytostaining, suggesting that ATE cells could serve as a quantitative platform to determine the pathogenesis of IBV.
[]
Cell tropism, viral replication and viral spread can be determined and quantified by immunocytostaining, suggesting that ATE cells could serve as a quantitative platform to determine the pathogenesis of IBV.
true
true
true
true
true
6,718
3
DISCUSSION
1
18
[ "R18", "R32", "R4" ]
19,793,537
pmid-18202946|pmid-17461266|pmid-16603523|pmid-16537586
It has been shown that sialic acid and HS may help IBV bind to its receptor on the cell membrane of target cells [18, 32].
[ "18", "32", "4" ]
122
39,024
0
false
It has been shown that sialic acid and HS may help IBV bind to its receptor on the cell membrane of target cells.
[ "18, 32" ]
It has been shown that sialic acid and HS may help IBV bind to its receptor on the cell membrane of target cells.
true
true
true
true
true
6,719
3
DISCUSSION
1
4
[ "R18", "R32", "R4" ]
19,793,537
pmid-18202946|pmid-17461266|pmid-16603523|pmid-16537586
Receptor binding triggers endocytosis and delivers the viral genome into the cytosol through pH-dependent membrane fusion [4].
[ "18", "32", "4" ]
126
39,025
1
false
Receptor binding triggers endocytosis and delivers the viral genome into the cytosol through pH-dependent membrane fusion.
[ "4" ]
Receptor binding triggers endocytosis and delivers the viral genome into the cytosol through pH-dependent membrane fusion.
true
true
true
true
true
6,719
3
DISCUSSION
1
18
[ "R18", "R32", "R4" ]
19,793,537
pmid-18202946|pmid-17461266|pmid-16603523|pmid-16537586
In this study, we demonstrate that none of the tested GAG interfered with IBV binding to ATE cells.
[ "18", "32", "4" ]
99
39,026
0
false
In this study, we demonstrate that none of the tested GAG interfered with IBV binding to ATE cells.
[]
In this study, we demonstrate that none of the tested GAG interfered with IBV binding to ATE cells.
true
true
true
true
true
6,719
3
DISCUSSION
1
18
[ "R18", "R32", "R4" ]
19,793,537
pmid-18202946|pmid-17461266|pmid-16603523|pmid-16537586
Further investigation is required to test whether this ineffectiveness is due to a lack of the XBBXBX H consensus sequence in the S protein sequences of TW IBV.
[ "18", "32", "4" ]
160
39,027
0
false
Further investigation is required to test whether this ineffectiveness is due to a lack of the XBBXBX H consensus sequence in the S protein sequences of TW IBV.
[]
Further investigation is required to test whether this ineffectiveness is due to a lack of the XBBXBX H consensus sequence in the S protein sequences of TW IBV.
true
true
true
true
true
6,719
4
DISCUSSION
0
null
null
19,793,537
null
In this study, we established a primary ATE cell culture system for the maintenance and amplification of epithelial cells of the chicken respiratory tract.
null
155
39,028
0
false
null
null
In this study, we established a primary ATE cell culture system for the maintenance and amplification of epithelial cells of the chicken respiratory tract.
true
true
true
true
true
6,720
4
DISCUSSION
0
null
null
19,793,537
null
Using these culture conditions, immortalized cell lines could potentially be established by overexpression of oncogenes, telomerase or anti-apoptotic genes.
null
156
39,029
0
false
null
null
Using these culture conditions, immortalized cell lines could potentially be established by overexpression of oncogenes, telomerase or anti-apoptotic genes.
true
true
true
true
true
6,720
4
DISCUSSION
0
null
null
19,793,537
null
Both primary cells and respiratory cell lines will provide a new window to reveal viral life cycles, viral persistence, virus-cell interaction and the pathogenesis of avian respiratory viruses.
null
193
39,030
0
false
null
null
Both primary cells and respiratory cell lines will provide a new window to reveal viral life cycles, viral persistence, virus-cell interaction and the pathogenesis of avian respiratory viruses.
true
true
true
true
true
6,720
0
DISCUSSION
0
null
null
19,509,018
null
In this report, we provide the evidence that Mstn disruption in Ldlr−/− mice reduces the development of proatherogenic dysipidemia and atherogenesis progression.
null
161
39,031
0
false
null
null
In this report, we provide the evidence that Mstn disruption in Ldlr−/− mice reduces the development of proatherogenic dysipidemia and atherogenesis progression.
true
true
true
true
true
6,721
0
DISCUSSION
0
null
null
19,509,018
null
The Mstn−/−/Ldlr−/− mice had lower plasma triglycerides, FFA, and non-HDL cholesterol than controls.
null
100
39,032
0
false
null
null
The Mstn−/−/Ldlr−/− mice had lower plasma triglycerides, FFA, and non-HDL cholesterol than controls.
true
true
true
true
true
6,721
0
DISCUSSION
0
null
null
19,509,018
null
Mstn−/−/Ldlr−/− mice also had lower hepatic VLDL secretion rates.
null
65
39,033
0
false
null
null
Mstn−/−/Ldlr−/− mice also had lower hepatic VLDL secretion rates.
true
true
true
true
true
6,721
0
DISCUSSION
0
null
null
19,509,018
null
Although we cannot exclude direct actions of myostatin on the blood vessel wall, it is likely that the more favorable plasma lipid profile was the key contributor to reduced atherogenesis progression observed in Mstn−/−/Ldlr−/− mice.
null
233
39,034
0
false
null
null
Although we cannot exclude direct actions of myostatin on the blood vessel wall, it is likely that the more favorable plasma lipid profile was the key contributor to reduced atherogenesis progression observed in Mstn−/−/Ldlr−/− mice.
true
true
true
true
true
6,721
1
DISCUSSION
1
23
[ "B23", "B25", "B28" ]
19,509,018
pmid-10949029|pmid-15680331|pmid-15522994
Mstn deletion prevented the development of diet-induced insulin resistance in Ldlr−/− mice.
[ "23", "25", "28" ]
91
39,035
0
false
Mstn deletion prevented the development of diet-induced insulin resistance in Ldlr−/− mice.
[]
Mstn deletion prevented the development of diet-induced insulin resistance in Ldlr−/− mice.
true
true
true
true
true
6,722
1
DISCUSSION
1
23
[ "B23", "B25", "B28" ]
19,509,018
pmid-10949029|pmid-15680331|pmid-15522994
Hyperinsulinemic-euglycemic clamp studies revealed that Mstn−/−/Ldlr−/− mice had significantly higher peripheral glucose disposal rates.
[ "23", "25", "28" ]
136
39,036
0
false
Hyperinsulinemic-euglycemic clamp studies revealed that Mstn−/−/Ldlr−/− mice had significantly higher peripheral glucose disposal rates.
[]
Hyperinsulinemic-euglycemic clamp studies revealed that Mstn−/−/Ldlr−/− mice had significantly higher peripheral glucose disposal rates.
true
true
true
true
true
6,722
1
DISCUSSION
1
23
[ "B23", "B25", "B28" ]
19,509,018
pmid-10949029|pmid-15680331|pmid-15522994
Furthermore, decreased circulating insulin as well as decreased glucose and adipose-derived FFA influx to the liver of the double-knockout mice may contribute to the protection against hepatic lipogenesis and hepatic insulin resistance (23,25,28).
[ "23", "25", "28" ]
247
39,037
0
false
Furthermore, decreased circulating insulin as well as decreased glucose and adipose-derived FFA influx to the liver of the double-knockout mice may contribute to the protection against hepatic lipogenesis and hepatic insulin resistance.
[ "23,25,28" ]
Furthermore, decreased circulating insulin as well as decreased glucose and adipose-derived FFA influx to the liver of the double-knockout mice may contribute to the protection against hepatic lipogenesis and hepatic insulin resistance.
true
true
true
true
true
6,722
2
DISCUSSION
1
31
[ "B31", "B32", "B11", "B33", "B11", "B11" ]
19,509,018
pmid-18203713|pmid-17030820|pmid-18249175|pmid-11175789|pmid-18249175|pmid-18249175
The mechanisms by which Mstn deletion improves insulin sensitivity are not fully understood.
[ "31", "32", "11", "33", "11", "11" ]
92
39,038
0
false
The mechanisms by which Mstn deletion improves insulin sensitivity are not fully understood.
[]
The mechanisms by which Mstn deletion improves insulin sensitivity are not fully understood.
true
true
true
true
true
6,723
2
DISCUSSION
1
31
[ "B31", "B32", "B11", "B33", "B11", "B11" ]
19,509,018
pmid-18203713|pmid-17030820|pmid-18249175|pmid-11175789|pmid-18249175|pmid-18249175
Mstn−/−/Ldlr−/− mice remained remarkably lean and resisted fat accumulation even when fed HFD for 12 weeks.
[ "31", "32", "11", "33", "11", "11" ]
107
39,039
0
false
Mstn−/−/Ldlr−/− mice remained remarkably lean and resisted fat accumulation even when fed HFD for 12 weeks.
[]
Mstn−/−/Ldlr−/− mice remained remarkably lean and resisted fat accumulation even when fed HFD for 12 weeks.
true
true
true
true
true
6,723
2
DISCUSSION
1
31
[ "B31", "B32", "B11", "B33", "B11", "B11" ]
19,509,018
pmid-18203713|pmid-17030820|pmid-18249175|pmid-11175789|pmid-18249175|pmid-18249175
Myostatin may exert complex effects on adipogenic differentiation (31,32).
[ "31", "32", "11", "33", "11", "11" ]
74
39,040
0
false
Myostatin may exert complex effects on adipogenic differentiation.
[ "31,32" ]
Myostatin may exert complex effects on adipogenic differentiation.
true
true
true
true
true
6,723
2
DISCUSSION
1
11
[ "B31", "B32", "B11", "B33", "B11", "B11" ]
19,509,018
pmid-18203713|pmid-17030820|pmid-18249175|pmid-11175789|pmid-18249175|pmid-18249175
In addition, it is possible that acquisition of hypermuscularity by itself could lead to leanness (11).
[ "31", "32", "11", "33", "11", "11" ]
103
39,041
1
false
In addition, it is possible that acquisition of hypermuscularity by itself could lead to leanness.
[ "11" ]
In addition, it is possible that acquisition of hypermuscularity by itself could lead to leanness.
true
true
true
true
true
6,723
2
DISCUSSION
1
11
[ "B31", "B32", "B11", "B33", "B11", "B11" ]
19,509,018
pmid-18203713|pmid-17030820|pmid-18249175|pmid-11175789|pmid-18249175|pmid-18249175
Indeed, mice with increased muscle oxidation, such as those overexpressing IGF-1 (33) or Akt-1 (11) in skeletal muscles, have little fat deposition.
[ "31", "32", "11", "33", "11", "11" ]
148
39,042
1
false
Indeed, mice with increased muscle oxidation, such as those overexpressing IGF-1 or Akt-1 in skeletal muscles, have little fat deposition.
[ "33", "11" ]
Indeed, mice with increased muscle oxidation, such as those overexpressing IGF-1 or Akt-1 in skeletal muscles, have little fat deposition.
true
true
true
true
true
6,723
2
DISCUSSION
1
11
[ "B31", "B32", "B11", "B33", "B11", "B11" ]
19,509,018
pmid-18203713|pmid-17030820|pmid-18249175|pmid-11175789|pmid-18249175|pmid-18249175
In our myostatin-deficient model, the marked hypertrophy of glycolytic skeletal muscle was associated with increased glucose uptake, lower blood glucose levels, and consequently lower circulating levels of insulin (11).
[ "31", "32", "11", "33", "11", "11" ]
219
39,043
1
false
In our myostatin-deficient model, the marked hypertrophy of glycolytic skeletal muscle was associated with increased glucose uptake, lower blood glucose levels, and consequently lower circulating levels of insulin.
[ "11" ]
In our myostatin-deficient model, the marked hypertrophy of glycolytic skeletal muscle was associated with increased glucose uptake, lower blood glucose levels, and consequently lower circulating levels of insulin.
true
true
true
true
true
6,723
3
DISCUSSION
1
25
[ "B25", "B26", "B34", "B11", "B35" ]
19,509,018
pmid-15680331|pmid-18349115|pmid-2407476|pmid-18249175|pmid-12920182
Increased hepatic fatty acid β-oxidation (FAO) and mitochondrial biogenesis with Mstn disruption may prevent the development of hepatic steatosis that was observed in Mstn+/+/Ldlr−/− controls (25,26).
[ "25", "26", "34", "11", "35" ]
200
39,044
0
false
Increased hepatic fatty acid β-oxidation (FAO) and mitochondrial biogenesis with Mstn disruption may prevent the development of hepatic steatosis that was observed in Mstn+/+/Ldlr−/− controls.
[ "25,26" ]
Increased hepatic fatty acid β-oxidation (FAO) and mitochondrial biogenesis with Mstn disruption may prevent the development of hepatic steatosis that was observed in Mstn+/+/Ldlr−/− controls.
true
true
true
true
true
6,724
3
DISCUSSION
1
25
[ "B25", "B26", "B34", "B11", "B35" ]
19,509,018
pmid-15680331|pmid-18349115|pmid-2407476|pmid-18249175|pmid-12920182
Consistent with the higher FAO rates, Mstn−/−/Ldlr−/− mice had higher ketone body production than controls.
[ "25", "26", "34", "11", "35" ]
107
39,045
0
false
Consistent with the higher FAO rates, Mstn−/−/Ldlr−/− mice had higher ketone body production than controls.
[]
Consistent with the higher FAO rates, Mstn−/−/Ldlr−/− mice had higher ketone body production than controls.
true
true
true
true
true
6,724
3
DISCUSSION
1
25
[ "B25", "B26", "B34", "B11", "B35" ]
19,509,018
pmid-15680331|pmid-18349115|pmid-2407476|pmid-18249175|pmid-12920182
Improved insulin sensitivity might be expected to suppress FAO and lower ketone body production.
[ "25", "26", "34", "11", "35" ]
96
39,046
0
false
Improved insulin sensitivity might be expected to suppress FAO and lower ketone body production.
[]
Improved insulin sensitivity might be expected to suppress FAO and lower ketone body production.
true
true
true
true
true
6,724
3
DISCUSSION
1
25
[ "B25", "B26", "B34", "B11", "B35" ]
19,509,018
pmid-15680331|pmid-18349115|pmid-2407476|pmid-18249175|pmid-12920182
However, insulin only effectively suppresses FAO in tissues, primarily muscle and fat, where glucose uptake is tightly regulated by insulin.
[ "25", "26", "34", "11", "35" ]
140
39,047
0
false
However, insulin only effectively suppresses FAO in tissues, primarily muscle and fat, where glucose uptake is tightly regulated by insulin.
[]
However, insulin only effectively suppresses FAO in tissues, primarily muscle and fat, where glucose uptake is tightly regulated by insulin.
true
true
true
true
true
6,724
3
DISCUSSION
1
34
[ "B25", "B26", "B34", "B11", "B35" ]
19,509,018
pmid-15680331|pmid-18349115|pmid-2407476|pmid-18249175|pmid-12920182
Because hepatic glucose uptake is not regulated by insulin (34), improved insulin sensitivity in the Mstn−/−/ Ldlr−/− mice does not pose limitation on liver FAO as it does in the skeletal muscle.
[ "25", "26", "34", "11", "35" ]
195
39,048
1
false
Because hepatic glucose uptake is not regulated by insulin, improved insulin sensitivity in the Mstn−/−/ Ldlr−/− mice does not pose limitation on liver FAO as it does in the skeletal muscle.
[ "34" ]
Because hepatic glucose uptake is not regulated by insulin, improved insulin sensitivity in the Mstn−/−/ Ldlr−/− mice does not pose limitation on liver FAO as it does in the skeletal muscle.
true
true
true
true
true
6,724
3
DISCUSSION
1
25
[ "B25", "B26", "B34", "B11", "B35" ]
19,509,018
pmid-15680331|pmid-18349115|pmid-2407476|pmid-18249175|pmid-12920182
This phenomenon has also been observed by others (11,35).
[ "25", "26", "34", "11", "35" ]
57
39,049
0
false
This phenomenon has also been observed by others.
[ "11,35" ]
This phenomenon has also been observed by others.
true
true
true
true
true
6,724
3
DISCUSSION
1
25
[ "B25", "B26", "B34", "B11", "B35" ]
19,509,018
pmid-15680331|pmid-18349115|pmid-2407476|pmid-18249175|pmid-12920182
Our data suggest that the increased ketone body production in the double-knockout mice may be a result of physiological adaptation to limited adipose tissue storage for dietary fats from HFD.
[ "25", "26", "34", "11", "35" ]
191
39,050
0
false
Our data suggest that the increased ketone body production in the double-knockout mice may be a result of physiological adaptation to limited adipose tissue storage for dietary fats from HFD.
[]
Our data suggest that the increased ketone body production in the double-knockout mice may be a result of physiological adaptation to limited adipose tissue storage for dietary fats from HFD.
true
true
true
true
true
6,724
4
DISCUSSION
1
10
[ "B10", "B36", "B37", "B38" ]
19,509,018
pmid-19295913|pmid-17347387|pmid-18948104|pmid-18718903
Myostatin may also indirectly affect cardiometabolic risk by its effects on myokine secretion by the skeletal muscle.
[ "10", "36", "37", "38" ]
117
39,051
0
false
Myostatin may also indirectly affect cardiometabolic risk by its effects on myokine secretion by the skeletal muscle.
[]
Myostatin may also indirectly affect cardiometabolic risk by its effects on myokine secretion by the skeletal muscle.
true
true
true
true
true
6,725
4
DISCUSSION
1
10
[ "B10", "B36", "B37", "B38" ]
19,509,018
pmid-19295913|pmid-17347387|pmid-18948104|pmid-18718903
Similar to systemic loss of Mstn, inhibition of myostatin signaling exclusively in the skeletal muscle was sufficient to resist diet-induced obesity and insulin resistance (10).
[ "10", "36", "37", "38" ]
177
39,052
1
false
Similar to systemic loss of Mstn, inhibition of myostatin signaling exclusively in the skeletal muscle was sufficient to resist diet-induced obesity and insulin resistance.
[ "10" ]
Similar to systemic loss of Mstn, inhibition of myostatin signaling exclusively in the skeletal muscle was sufficient to resist diet-induced obesity and insulin resistance.
true
true
true
true
true
6,725
4
DISCUSSION
1
36
[ "B10", "B36", "B37", "B38" ]
19,509,018
pmid-19295913|pmid-17347387|pmid-18948104|pmid-18718903
Myokines, such as interleukin-6, can alter metabolic states (36).
[ "10", "36", "37", "38" ]
65
39,053
1
false
Myokines, such as interleukin-6, can alter metabolic states.
[ "36" ]
Myokines, such as interleukin-6, can alter metabolic states.
true
true
true
true
true
6,725
4
DISCUSSION
1
10
[ "B10", "B36", "B37", "B38" ]
19,509,018
pmid-19295913|pmid-17347387|pmid-18948104|pmid-18718903
Other myokines, such as fibroblast growth factor-21 (Fgf-21) and follistatin like-1 (Fstl-1), may also have salutary effects on fat accumulation and insulin sensitivity (37,38).
[ "10", "36", "37", "38" ]
177
39,054
0
false
Other myokines, such as fibroblast growth factor-21 (Fgf-21) and follistatin like-1 (Fstl-1), may also have salutary effects on fat accumulation and insulin sensitivity.
[ "37,38" ]
Other myokines, such as fibroblast growth factor-21 and follistatin like-1, may also have salutary effects on fat accumulation and insulin sensitivity.
true
true
true
true
true
6,725
5
DISCUSSION
1
39
[ "B39" ]
19,509,018
NA
In summary, we have demonstrated here that Mstn deletion has beneficial cardiometabolic effects in an animal model of atherosclerosis.
[ "39" ]
134
39,055
0
false
In summary, we have demonstrated here that Mstn deletion has beneficial cardiometabolic effects in an animal model of atherosclerosis.
[]
In summary, we have demonstrated here that Mstn deletion has beneficial cardiometabolic effects in an animal model of atherosclerosis.
true
true
true
true
true
6,726
5
DISCUSSION
1
39
[ "B39" ]
19,509,018
NA
Mstn−/−/Ldlr−/− mice are partially protected against not only fat accumulation and insulin resistance but also the development of proatherogenic dyslipidemia and atherosclerosis.
[ "39" ]
178
39,056
0
false
Mstn−/−/Ldlr−/− mice are partially protected against not only fat accumulation and insulin resistance but also the development of proatherogenic dyslipidemia and atherosclerosis.
[]
Mstn−/−/Ldlr−/− mice are partially protected against not only fat accumulation and insulin resistance but also the development of proatherogenic dyslipidemia and atherosclerosis.
true
true
true
true
true
6,726
5
DISCUSSION
1
39
[ "B39" ]
19,509,018
NA
These proof-of-concept studies raise the possibility that myostatin inhibitors may be useful agents for the prevention or treatment of atherosclerosis.
[ "39" ]
151
39,057
0
false
These proof-of-concept studies raise the possibility that myostatin inhibitors may be useful agents for the prevention or treatment of atherosclerosis.
[]
These proof-of-concept studies raise the possibility that myostatin inhibitors may be useful agents for the prevention or treatment of atherosclerosis.
true
true
true
true
true
6,726
5
DISCUSSION
1
39
[ "B39" ]
19,509,018
NA
Importantly, administration of myostatin inhibitors to humans have demonstrated specificity, safety, and effectiveness in increasing muscle mass and decreasing fat mass (39).
[ "39" ]
174
39,058
1
false
Importantly, administration of myostatin inhibitors to humans have demonstrated specificity, safety, and effectiveness in increasing muscle mass and decreasing fat mass.
[ "39" ]
Importantly, administration of myostatin inhibitors to humans have demonstrated specificity, safety, and effectiveness in increasing muscle mass and decreasing fat mass.
true
true
true
true
true
6,726
5
DISCUSSION
1
39
[ "B39" ]
19,509,018
NA
To the extent that loss of skeletal muscle mass, adiposity, and atherogenesis occur contemporaneously during aging and in many chronic illnesses, new classes of promyogenic drugs, such as myostatin inhibitors, that increase skeletal muscle mass and retard fat accumulation are particularly attractive against these cardi...
[ "39" ]
341
39,059
0
false
To the extent that loss of skeletal muscle mass, adiposity, and atherogenesis occur contemporaneously during aging and in many chronic illnesses, new classes of promyogenic drugs, such as myostatin inhibitors, that increase skeletal muscle mass and retard fat accumulation are particularly attractive against these cardi...
[]
To the extent that loss of skeletal muscle mass, adiposity, and atherogenesis occur contemporaneously during aging and in many chronic illnesses, new classes of promyogenic drugs, such as myostatin inhibitors, that increase skeletal muscle mass and retard fat accumulation are particularly attractive against these cardi...
true
true
true
true
true
6,726
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B7", "B8", "B10" ]
20,577,608
pmid-9426746|pmid-2898402|pmid-7427654|pmid-7618052|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-943076|pmid-943076|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-15572486|pmid-11450974
Urinary incontinence (UI) is common in females.
[ "1", "2", "3", "4", "5", "7", "8", "10" ]
47
39,060
0
false
Urinary incontinence (UI) is common in females.
[]
Urinary incontinence (UI) is common in females.
true
true
true
true
true
6,727
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B7", "B8", "B10" ]
20,577,608
pmid-9426746|pmid-2898402|pmid-7427654|pmid-7618052|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-943076|pmid-943076|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-15572486|pmid-11450974
The incidence of female UI is 14-41% [1], and the incidence increases with aging [2,3].
[ "1", "2", "3", "4", "5", "7", "8", "10" ]
87
39,061
1
false
The incidence of female UI is 14-41%, and the incidence increases with aging.
[ "1", "2,3" ]
The incidence of female UI is 14-41%, and the incidence increases with aging.
true
true
true
true
true
6,727
0
INTRODUCTION
1
4
[ "B1", "B2", "B3", "B4", "B5", "B7", "B8", "B10" ]
20,577,608
pmid-9426746|pmid-2898402|pmid-7427654|pmid-7618052|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-943076|pmid-943076|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-15572486|pmid-11450974
The tension-free vaginal tape (TVT) procedure, which was first described in 1996 by Ulmsten and Petros, is a modified suburethral sling procedure for treating female stress urinary incontinence (SUI) based on the integral theory [4].
[ "1", "2", "3", "4", "5", "7", "8", "10" ]
233
39,062
1
false
The tension-free vaginal tape (TVT) procedure, which was first described in 1996 by Ulmsten and Petros, is a modified suburethral sling procedure for treating female stress urinary incontinence (SUI) based on the integral theory.
[ "4" ]
The tension-free vaginal tape (TVT) procedure, which was first described in 1996 by Ulmsten and Petros, is a modified suburethral sling procedure for treating female stress urinary incontinence (SUI) based on the integral theory.
true
true
true
true
true
6,727
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B7", "B8", "B10" ]
20,577,608
pmid-9426746|pmid-2898402|pmid-7427654|pmid-7618052|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-943076|pmid-943076|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-15572486|pmid-11450974
The TVT procedure provides high short- and intermediate-term success rates [5-7].
[ "1", "2", "3", "4", "5", "7", "8", "10" ]
81
39,063
0
false
The TVT procedure provides high short- and intermediate-term success rates.
[ "5-7" ]
The TVT procedure provides high short- and intermediate-term success rates.
true
true
true
true
true
6,727
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B7", "B8", "B10" ]
20,577,608
pmid-9426746|pmid-2898402|pmid-7427654|pmid-7618052|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-943076|pmid-943076|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-15572486|pmid-11450974
A few studies showed that the cure rate of the TVT procedure is 76.9-80% after long-term follow up [8-10].
[ "1", "2", "3", "4", "5", "7", "8", "10" ]
106
39,064
0
false
A few studies showed that the cure rate of the TVT procedure is 76.9-80% after long-term follow up.
[ "8-10" ]
A few studies showed that the cure rate of the TVT procedure is 76.9-80% after long-term follow up.
true
true
true
true
true
6,727
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B7", "B8", "B10" ]
20,577,608
pmid-9426746|pmid-2898402|pmid-7427654|pmid-7618052|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-943076|pmid-943076|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-15572486|pmid-11450974
However, long-term follow-up data on the TVT procedure are currently lacking in Korea.
[ "1", "2", "3", "4", "5", "7", "8", "10" ]
86
39,065
0
false
However, long-term follow-up data on the TVT procedure are currently lacking in Korea.
[]
However, long-term follow-up data on the TVT procedure are currently lacking in Korea.
true
true
true
true
true
6,727
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B7", "B8", "B10" ]
20,577,608
pmid-9426746|pmid-2898402|pmid-7427654|pmid-7618052|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-943076|pmid-943076|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-15572486|pmid-11450974
Therefore, we evaluated the long-term results of the TVT procedure for the treatment of female UI with 6-year follow-up data.
[ "1", "2", "3", "4", "5", "7", "8", "10" ]
125
39,066
0
false
Therefore, we evaluated the long-term results of the TVT procedure for the treatment of female UI with 6-year follow-up data.
[]
Therefore, we evaluated the long-term results of the TVT procedure for the treatment of female UI with 6-year follow-up data.
true
true
true
true
true
6,727
0
DISCUSSION
1
17
[ "B17", "B17", "B5", "B7", "B8", "B10", "B18", "B19" ]
20,577,608
pmid-9426746|pmid-2898402|pmid-7427654|pmid-7618052|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-943076|pmid-943076|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-15572486|pmid-11450974
SUI is known to occur when the bladder neck and posterior urethra escape the normal anatomical position [17].
[ "17", "17", "5", "7", "8", "10", "18", "19" ]
109
39,067
1
false
SUI is known to occur when the bladder neck and posterior urethra escape the normal anatomical position.
[ "17" ]
SUI is known to occur when the bladder neck and posterior urethra escape the normal anatomical position.
true
true
true
true
true
6,728
0
DISCUSSION
1
17
[ "B17", "B17", "B5", "B7", "B8", "B10", "B18", "B19" ]
20,577,608
pmid-9426746|pmid-2898402|pmid-7427654|pmid-7618052|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-943076|pmid-943076|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-15572486|pmid-11450974
During a Valsalva maneuver, the pressure of the bladder neck and posterior urethra is lower than intravesical pressure, which leads to incontinence [17].
[ "17", "17", "5", "7", "8", "10", "18", "19" ]
153
39,068
1
false
During a Valsalva maneuver, the pressure of the bladder neck and posterior urethra is lower than intravesical pressure, which leads to incontinence.
[ "17" ]
During a Valsalva maneuver, the pressure of the bladder neck and posterior urethra is lower than intravesical pressure, which leads to incontinence.
true
true
true
true
true
6,728
0
DISCUSSION
1
17
[ "B17", "B17", "B5", "B7", "B8", "B10", "B18", "B19" ]
20,577,608
pmid-9426746|pmid-2898402|pmid-7427654|pmid-7618052|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-943076|pmid-943076|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-15572486|pmid-11450974
The short-term results of TVT have shown cure rates between 80% and 100% [5-7].
[ "17", "17", "5", "7", "8", "10", "18", "19" ]
79
39,069
0
false
The short-term results of TVT have shown cure rates between 80% and 100%.
[ "5-7" ]
The short-term results of TVT have shown cure rates between 80% and 100%.
true
true
true
true
true
6,728
0
DISCUSSION
1
17
[ "B17", "B17", "B5", "B7", "B8", "B10", "B18", "B19" ]
20,577,608
pmid-9426746|pmid-2898402|pmid-7427654|pmid-7618052|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-943076|pmid-943076|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-15572486|pmid-11450974
Long-term cure rates are reported to be from 71% to 86% [8-10].
[ "17", "17", "5", "7", "8", "10", "18", "19" ]
63
39,070
0
false
Long-term cure rates are reported to be from 71% to 86%.
[ "8-10" ]
Long-term cure rates are reported to be from 71% to 86%.
true
true
true
true
true
6,728
0
DISCUSSION
1
18
[ "B17", "B17", "B5", "B7", "B8", "B10", "B18", "B19" ]
20,577,608
pmid-9426746|pmid-2898402|pmid-7427654|pmid-7618052|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-943076|pmid-943076|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-15572486|pmid-11450974
Nilsson et al performed 7 years of long-term follow-up of 80 patients in 2004 and reported an 81.3% cure rate [18].
[ "17", "17", "5", "7", "8", "10", "18", "19" ]
115
39,071
1
false
Nilsson et al performed 7 years of long-term follow-up of 80 patients in 2004 and reported an 81.3% cure rate.
[ "18" ]
Nilsson et al performed 7 years of long-term follow-up of 80 patients in 2004 and reported an 81.3% cure rate.
true
true
true
true
true
6,728
0
DISCUSSION
1
17
[ "B17", "B17", "B5", "B7", "B8", "B10", "B18", "B19" ]
20,577,608
pmid-9426746|pmid-2898402|pmid-7427654|pmid-7618052|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-943076|pmid-943076|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-15572486|pmid-11450974
In our study, the long-term cure rate was 83.0% (117/141), and this result is almost the same as the results of previous studies.
[ "17", "17", "5", "7", "8", "10", "18", "19" ]
129
39,072
0
false
In our study, the long-term cure rate was 83.0%, and this result is almost the same as the results of previous studies.
[ "117/141" ]
In our study, the long-term cure rate was 83.0%, and this result is almost the same as the results of previous studies.
true
true
true
true
true
6,728
0
DISCUSSION
1
17
[ "B17", "B17", "B5", "B7", "B8", "B10", "B18", "B19" ]
20,577,608
pmid-9426746|pmid-2898402|pmid-7427654|pmid-7618052|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-943076|pmid-943076|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-15572486|pmid-11450974
Razapour and Ulmsten performed TVT on 80 patients with mixed incontinence accompanied by urgency UI and reported an 85% cure rate, a 4% rate of improvement, and an 11% treatment failure rate within a mean follow-up period of 4 years (range, 3-5 years)
[ "17", "17", "5", "7", "8", "10", "18", "19" ]
251
39,073
0
false
Razapour and Ulmsten performed TVT on 80 patients with mixed incontinence accompanied by urgency UI and reported an 85% cure rate, a 4% rate of improvement, and an 11% treatment failure rate within a mean follow-up period of 4 years
[ "range, 3-5 years" ]
Razapour and Ulmsten performed TVT on 80 patients with mixed incontinence accompanied by urgency UI and reported an 85% cure rate, a 4% rate of improvement, and an 11% treatment failure rate within a mean follow-up period of 4 years
true
true
false
true
false
6,728
0
DISCUSSION
1
17
[ "B17", "B17", "B5", "B7", "B8", "B10", "B18", "B19" ]
20,577,608
pmid-9426746|pmid-2898402|pmid-7427654|pmid-7618052|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-943076|pmid-943076|pmid-19579203|pmid-11305550|pmid-11450979|pmid-17593097|pmid-15572486|pmid-11450974
In our study, the cure rate of patients with MUI at 1 year postoperatively was 89.8%, and the cure rate at 6 years postoperatively was 79.4%.
[ "17", "17", "5", "7", "8", "10", "18", "19" ]
141
39,074
0
false
In our study, the cure rate of patients with MUI at 1 year postoperatively was 89.8%, and the cure rate at 6 years postoperatively was 79.4%.
[]
In our study, the cure rate of patients with MUI at 1 year postoperatively was 89.8%, and the cure rate at 6 years postoperatively was 79.4%.
true
true
true
true
true
6,728
1
DISCUSSION
1
20
[ "B20", "B21", "B22", "B22" ]
20,577,608
pmid-12270565|pmid-12691935|pmid-15994615|pmid-15994615
In the MUI group, the cure rate of urgency incontinence was decreased from 81.9% at 1 year postoperatively to 58.8% at 6 years postoperatively.
[ "20", "21", "22", "22" ]
143
39,075
0
false
In the MUI group, the cure rate of urgency incontinence was decreased from 81.9% at 1 year postoperatively to 58.8% at 6 years postoperatively.
[]
In the MUI group, the cure rate of urgency incontinence was decreased from 81.9% at 1 year postoperatively to 58.8% at 6 years postoperatively.
true
true
true
true
true
6,729
1
DISCUSSION
1
20
[ "B20", "B21", "B22", "B22" ]
20,577,608
pmid-12270565|pmid-12691935|pmid-15994615|pmid-15994615
Previous studies reported that the cure rate of urgency UI in MUI patients was 69-85% with short-term follow-up
[ "20", "21", "22", "22" ]
111
39,076
0
false
Previous studies reported that the cure rate of urgency UI in MUI patients was 69-85% with short-term follow-up
[]
Previous studies reported that the cure rate of urgency UI in MUI patients was 69-85% with short-term follow-up
true
true
false
true
false
6,729
1
DISCUSSION
1
22
[ "B20", "B21", "B22", "B22" ]
20,577,608
pmid-12270565|pmid-12691935|pmid-15994615|pmid-15994615
Holmgren et al reported that the cure rate of urgency UI at 3 years postoperatively was 60% and that at 6 to 8 years was 30% [22].
[ "20", "21", "22", "22" ]
130
39,077
1
false
Holmgren et al reported that the cure rate of urgency UI at 3 years postoperatively was 60% and that at 6 to 8 years was 30%.
[ "22" ]
Holmgren et al reported that the cure rate of urgency UI at 3 years postoperatively was 60% and that at 6 to 8 years was 30%.
true
true
true
true
true
6,729
1
DISCUSSION
1
22
[ "B20", "B21", "B22", "B22" ]
20,577,608
pmid-12270565|pmid-12691935|pmid-15994615|pmid-15994615
This might be due to an aging effect or atrophy of the bladder epithelium, which could be associated with the increased use of local estrogens or with neurological disorders [22].
[ "20", "21", "22", "22" ]
179
39,078
1
false
This might be due to an aging effect or atrophy of the bladder epithelium, which could be associated with the increased use of local estrogens or with neurological disorders.
[ "22" ]
This might be due to an aging effect or atrophy of the bladder epithelium, which could be associated with the increased use of local estrogens or with neurological disorders.
true
true
true
true
true
6,729
2
DISCUSSION
1
23
[ "B23", "B24", "B25", "B26", "B27" ]
20,577,608
NA|pmid-3822288|pmid-2392816|NA|pmid-11294532
There is still controversy about the difference between success rates of TVT procedures according to the VLPP.
[ "23", "24", "25", "26", "27" ]
110
39,079
0
false
There is still controversy about the difference between success rates of TVT procedures according to the VLPP.
[]
There is still controversy about the difference between success rates of TVT procedures according to the VLPP.
true
true
true
true
true
6,730
2
DISCUSSION
1
23
[ "B23", "B24", "B25", "B26", "B27" ]
20,577,608
NA|pmid-3822288|pmid-2392816|NA|pmid-11294532
In 2001, Kim and Lee reported that the success rate of patients with a VLPP of less than 60 cmH2O was low
[ "23", "24", "25", "26", "27" ]
105
39,080
0
false
In 2001, Kim and Lee reported that the success rate of patients with a VLPP of less than 60 cmH2O was low
[]
In 2001, Kim and Lee reported that the success rate of patients with a VLPP of less than 60 cmH2O was low
true
true
false
true
false
6,730
2
DISCUSSION
1
26
[ "B23", "B24", "B25", "B26", "B27" ]
20,577,608
NA|pmid-3822288|pmid-2392816|NA|pmid-11294532
In addition, Sand et al and Koonings et al reported that when the VLPP was lower than 60 cmH2O, the failure rate of the Burch operation procedure was 50% [24,25], and Song et al reported that TVT in patients with a low VLPP should be considered cautiously [26].
[ "23", "24", "25", "26", "27" ]
261
39,081
1
false
In addition, Sand et al and Koonings et al reported that when the VLPP was lower than 60 cmH2O, the failure rate of the Burch operation procedure was 50%, and Song et al reported that TVT in patients with a low VLPP should be considered cautiously.
[ "24,25", "26" ]
In addition, Sand et al and Koonings et al reported that when the VLPP was lower than 60 cmH2O, the failure rate of the Burch operation procedure was 50%, and Song et al reported that TVT in patients with a low VLPP should be considered cautiously.
true
true
true
true
true
6,730
2
DISCUSSION
1
27
[ "B23", "B24", "B25", "B26", "B27" ]
20,577,608
NA|pmid-3822288|pmid-2392816|NA|pmid-11294532
Conversely, Hsieh et al reported that in women with a VLPP of less than 60 cmH2O, the success rate showed a high percentage of 91.7%, suggesting that VLPP had no correlation with the success rate [27].
[ "23", "24", "25", "26", "27" ]
201
39,082
1
false
Conversely, Hsieh et al reported that in women with a VLPP of less than 60 cmH2O, the success rate showed a high percentage of 91.7%, suggesting that VLPP had no correlation with the success rate.
[ "27" ]
Conversely, Hsieh et al reported that in women with a VLPP of less than 60 cmH2O, the success rate showed a high percentage of 91.7%, suggesting that VLPP had no correlation with the success rate.
true
true
true
true
true
6,730
2
DISCUSSION
1
23
[ "B23", "B24", "B25", "B26", "B27" ]
20,577,608
NA|pmid-3822288|pmid-2392816|NA|pmid-11294532
In our study, we divided the patients into two groups, one with a VLPP of lower than 60 cmH2O and the other with a VLPP of higher than 60 cmH2O, and the success rates did not differ significantly between the groups (81.1% versus 86.7%; p=0.59).
[ "23", "24", "25", "26", "27" ]
244
39,083
0
false
In our study, we divided the patients into two groups, one with a VLPP of lower than 60 cmH2O and the other with a VLPP of higher than 60 cmH2O, and the success rates did not differ significantly between the groups (81.1% versus 86.7%; p=0.59).
[]
In our study, we divided the patients into two groups, one with a VLPP of lower than 60 cmH2O and the other with a VLPP of higher than 60 cmH2O, and the success rates did not differ significantly between the groups (81.1% versus 86.7%; p=0.59).
true
true
true
true
true
6,730
2
DISCUSSION
1
23
[ "B23", "B24", "B25", "B26", "B27" ]
20,577,608
NA|pmid-3822288|pmid-2392816|NA|pmid-11294532
According to the Ingelman-Sundberg scale, there was no significant difference in the success rate between the symptom Grade II group and the Grade III group postoperatively (83.3% versus 83.9%; p=1.000).
[ "23", "24", "25", "26", "27" ]
203
39,084
0
false
According to the Ingelman-Sundberg scale, there was no significant difference in the success rate between the symptom Grade II group and the Grade III group postoperatively (83.3% versus 83.9%; p=1.000).
[]
According to the Ingelman-Sundberg scale, there was no significant difference in the success rate between the symptom Grade II group and the Grade III group postoperatively.
true
true
true
true
true
6,730
3
DISCUSSION
1
14
[ "B14" ]
20,577,608
pmid-11857671
BFLUTS questionnaire is a self-descriptive urinary symptom measurement tool composed of 4 domains and 34 questions that was developed in 1996 by Abrams et al in the United Kingdom [14].
[ "14" ]
185
39,085
1
false
BFLUTS questionnaire is a self-descriptive urinary symptom measurement tool composed of 4 domains and 34 questions that was developed in 1996 by Abrams et al in the United Kingdom.
[ "14" ]
BFLUTS questionnaire is a self-descriptive urinary symptom measurement tool composed of 4 domains and 34 questions that was developed in 1996 by Abrams et al in the United Kingdom.
true
true
true
true
true
6,731
3
DISCUSSION
1
14
[ "B14" ]
20,577,608
pmid-11857671
The 4 domains of the questionnaire are lower urinary tract symptom severity, sexual function, bothersomeness, and impact and quality of life.
[ "14" ]
141
39,086
0
false
The 4 domains of the questionnaire are lower urinary tract symptom severity, sexual function, bothersomeness, and impact and quality of life.
[]
The 4 domains of the questionnaire are lower urinary tract symptom severity, sexual function, bothersomeness, and impact and quality of life.
true
true
true
true
true
6,731
3
DISCUSSION
1
14
[ "B14" ]
20,577,608
pmid-11857671
The scale of answers ranges from 'none' to 'always'.
[ "14" ]
52
39,087
0
false
The scale of answers ranges from 'none' to 'always'.
[]
The scale of answers ranges from 'none' to 'always'.
true
true
true
true
true
6,731
3
DISCUSSION
1
14
[ "B14" ]
20,577,608
pmid-11857671
The questionnaire is designed so that the severity of symptoms can be evaluated and the impact of LUTS on daily life can be measured on every question.
[ "14" ]
151
39,088
0
false
The questionnaire is designed so that the severity of symptoms can be evaluated and the impact of LUTS on daily life can be measured on every question.
[]
The questionnaire is designed so that the severity of symptoms can be evaluated and the impact of LUTS on daily life can be measured on every question.
true
true
true
true
true
6,731
3
DISCUSSION
1
14
[ "B14" ]
20,577,608
pmid-11857671
This is useful in evaluating the change in urinary symptoms before and after treatment, and the reproducibility and validity are known to be reliable.
[ "14" ]
150
39,089
0
false
This is useful in evaluating the change in urinary symptoms before and after treatment, and the reproducibility and validity are known to be reliable.
[]
This is useful in evaluating the change in urinary symptoms before and after treatment, and the reproducibility and validity are known to be reliable.
true
true
true
true
true
6,731
3
DISCUSSION
1
14
[ "B14" ]
20,577,608
pmid-11857671
In our study, we selected some questions from the questionnaire associated with urgency, urgency UI, SUI, incontinence amount, straining, intermittency, feeling of incomplete emptying, and quality of life.
[ "14" ]
205
39,090
0
false
In our study, we selected some questions from the questionnaire associated with urgency, urgency UI, SUI, incontinence amount, straining, intermittency, feeling of incomplete emptying, and quality of life.
[]
In our study, we selected some questions from the questionnaire associated with urgency, urgency UI, SUI, incontinence amount, straining, intermittency, feeling of incomplete emptying, and quality of life.
true
true
true
true
true
6,731
3
DISCUSSION
1
14
[ "B14" ]
20,577,608
pmid-11857671
Independent from the BFLUTS items, 2 questions were added concerning global satisfaction and recommendation.
[ "14" ]
108
39,091
0
false
Independent from the BFLUTS items, 2 questions were added concerning global satisfaction and recommendation.
[]
Independent from the BFLUTS items, 2 questions were added concerning global satisfaction and recommendation.
true
true
true
true
true
6,731
4
DISCUSSION
1
6
[ "B6", "B28" ]
20,577,608
pmid-10426241|pmid-15217442
One of the most common complications of TVT is bladder perforation, which is reported to have a rate of occurrence of 2.3% to 10%
[ "6", "28" ]
129
39,092
0
false
One of the most common complications of TVT is bladder perforation, which is reported to have a rate of occurrence of 2.3% to 10%
[]
One of the most common complications of TVT is bladder perforation, which is reported to have a rate of occurrence of 2.3% to 10%
true
true
false
true
false
6,732
4
DISCUSSION
1
6
[ "B6", "B28" ]
20,577,608
pmid-10426241|pmid-15217442
In our study, 9 patients out of 141 (6.4%) were reported to experience bladder perforation.
[ "6", "28" ]
91
39,093
0
false
In our study, 9 patients out of 141 were reported to experience bladder perforation.
[ "6.4%" ]
In our study, 9 patients out of 141 were reported to experience bladder perforation.
true
true
true
true
true
6,732
4
DISCUSSION
1
6
[ "B6", "B28" ]
20,577,608
pmid-10426241|pmid-15217442
Our results are comparable with those of previous studies.
[ "6", "28" ]
58
39,094
0
false
Our results are comparable with those of previous studies.
[]
Our results are comparable with those of previous studies.
true
true
true
true
true
6,732
5
DISCUSSION
0
null
null
20,577,608
null
The limitations of this study are, first, that it was a retrospective study, and second, that the BFLUTS questionnaire was used selectively.
null
140
39,095
0
false
null
null
The limitations of this study are, first, that it was a retrospective study, and second, that the BFLUTS questionnaire was used selectively.
true
true
true
true
true
6,733
5
DISCUSSION
0
null
null
20,577,608
null
We added subjective questions of our own accord, therefore lowering the validity of the questionnaire.
null
102
39,096
0
false
null
null
We added subjective questions of our own accord, therefore lowering the validity of the questionnaire.
true
true
true
true
true
6,733
5
DISCUSSION
0
null
null
20,577,608
null
Third, there was a difference in the follow-up evaluation performed between 1 year and 6 years after the TVT, yet these results were compared and analyzed.
null
155
39,097
0
false
null
null
Third, there was a difference in the follow-up evaluation performed between 1 year and 6 years after the TVT, yet these results were compared and analyzed.
true
true
true
true
true
6,733
5
DISCUSSION
0
null
null
20,577,608
null
Fourth, the study was based on the patients' subjective data and satisfaction.
null
78
39,098
0
false
null
null
Fourth, the study was based on the patients' subjective data and satisfaction.
true
true
true
true
true
6,733
5
DISCUSSION
0
null
null
20,577,608
null
The severity of symptoms would probably vary from patient to patient; therefore, judgement of cure, improvement, and failure on the basis of these analyses may not always be accurate.
null
183
39,099
0
false
null
null
The severity of symptoms would probably vary from patient to patient; therefore, judgement of cure, improvement, and failure on the basis of these analyses may not always be accurate.
true
true
true
true
true
6,733
5
DISCUSSION
0
null
null
20,577,608
null
If objective data such as uroflowmetry, residual urine measurement, and stress test had been collected at the 6-year follow-up, the results would probably have been more significant and reliable.
null
195
39,100
0
false
null
null
If objective data such as uroflowmetry, residual urine measurement, and stress test had been collected at the 6-year follow-up, the results would probably have been more significant and reliable.
true
true
true
true
true
6,733
5
DISCUSSION
0
null
null
20,577,608
null
Finally, this study was dependent on a questionnaire conducted by telephone interview; therefore, this study is vulnerable to selection bias.
null
141
39,101
0
false
null
null
Finally, this study was dependent on a questionnaire conducted by telephone interview; therefore, this study is vulnerable to selection bias.
true
true
true
true
true
6,733
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B6", "B7" ]
19,321,500
pmid-3181145|pmid-7826014|pmid-15463739|pmid-15811531|pmid-14555465|pmid-17765983|pmid-1349605|pmid-17041189
Leishmaniasis is caused by trypanosomatid parasites that cycle between invertebrate vectors and vertebrate hosts, transforming between the promastigote and amastigote life forms, respectively.
[ "1", "2", "3", "4", "5", "6", "7" ]
192
39,102
0
false
Leishmaniasis is caused by trypanosomatid parasites that cycle between invertebrate vectors and vertebrate hosts, transforming between the promastigote and amastigote life forms, respectively.
[]
Leishmaniasis is caused by trypanosomatid parasites that cycle between invertebrate vectors and vertebrate hosts, transforming between the promastigote and amastigote life forms, respectively.
true
true
true
true
true
6,734
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B6", "B7" ]
19,321,500
pmid-3181145|pmid-7826014|pmid-15463739|pmid-15811531|pmid-14555465|pmid-17765983|pmid-1349605|pmid-17041189
Environmental conditions, such as temperature and pH switches, were shown to induce a stage-specific pattern of gene expression (1,2), which in some species is sufficient to produce the axenic form (amastigotes) observed in mammalian cells (3,4).
[ "1", "2", "3", "4", "5", "6", "7" ]
246
39,103
0
false
Environmental conditions, such as temperature and pH switches, were shown to induce a stage-specific pattern of gene expression, which in some species is sufficient to produce the axenic form (amastigotes) observed in mammalian cells.
[ "1,2", "3,4" ]
Environmental conditions, such as temperature and pH switches, were shown to induce a stage-specific pattern of gene expression, which in some species is sufficient to produce the axenic form (amastigotes) observed in mammalian cells.
true
true
true
true
true
6,734
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B6", "B7" ]
19,321,500
pmid-3181145|pmid-7826014|pmid-15463739|pmid-15811531|pmid-14555465|pmid-17765983|pmid-1349605|pmid-17041189
Trypanosomatids are ancient eukaryotes that diverged early in evolution and therefore display a variety of unique molecular features.
[ "1", "2", "3", "4", "5", "6", "7" ]
133
39,104
0
false
Trypanosomatids are ancient eukaryotes that diverged early in evolution and therefore display a variety of unique molecular features.
[]
Trypanosomatids are ancient eukaryotes that diverged early in evolution and therefore display a variety of unique molecular features.
true
true
true
true
true
6,734
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B6", "B7" ]
19,321,500
pmid-3181145|pmid-7826014|pmid-15463739|pmid-15811531|pmid-14555465|pmid-17765983|pmid-1349605|pmid-17041189
Transcription of protein-coding genes is polycistronic and the resulting pre-mRNAs are processed by trans-splicing and polyadenylation (5,6).
[ "1", "2", "3", "4", "5", "6", "7" ]
141
39,105
0
false
Transcription of protein-coding genes is polycistronic and the resulting pre-mRNAs are processed by trans-splicing and polyadenylation.
[ "5,6" ]
Transcription of protein-coding genes is polycistronic and the resulting pre-mRNAs are processed by trans-splicing and polyadenylation.
true
true
true
true
true
6,734
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B6", "B7" ]
19,321,500
pmid-3181145|pmid-7826014|pmid-15463739|pmid-15811531|pmid-14555465|pmid-17765983|pmid-1349605|pmid-17041189
During trans-splicing, a capped 39-nt exon of the spliced leader RNA is joined to the 5′-end of all transcripts.
[ "1", "2", "3", "4", "5", "6", "7" ]
112
39,106
0
false
During trans-splicing, a capped 39-nt exon of the spliced leader RNA is joined to the 5′-end of all transcripts.
[]
During trans-splicing, a capped 39-nt exon of the spliced leader RNA is joined to the 5′-end of all transcripts.
true
true
true
true
true
6,734
0
INTRODUCTION
1
7
[ "B1", "B2", "B3", "B4", "B5", "B6", "B7" ]
19,321,500
pmid-3181145|pmid-7826014|pmid-15463739|pmid-15811531|pmid-14555465|pmid-17765983|pmid-1349605|pmid-17041189
The 5′-cap of trypanosomatids consists of a highly modified structure, which in addition to the m7GTP cap found at the 5′-end of most eukaryotic mRNAs, contains 2′-O-methylations on the ribose moieties of the first four transcribed nucleotides and unusual base-methylations on the first adenine and fourth uridine (m7Gpp...
[ "1", "2", "3", "4", "5", "6", "7" ]
392
39,107
1
false
The 5′-cap of trypanosomatids consists of a highly modified structure, which in addition to the m7GTP cap found at the 5′-end of most eukaryotic mRNAs, contains 2′-O-methylations on the ribose moieties of the first four transcribed nucleotides and unusual base-methylations on the first adenine and fourth uridine ; this...
[ "m7Gpppm36,6,2′Apm2′Apm2′Cpm23,2′U", "7" ]
The 5′-cap of trypanosomatids consists of a highly modified structure, which in addition to the m7GTP cap found at the 5′-end of most eukaryotic mRNAs, contains 2′-O-methylations on the ribose moieties of the first four transcribed nucleotides and unusual base-methylations on the first adenine and fourth uridine ; this...
true
true
true
true
true
6,734
1
INTRODUCTION
1
8
[ "B8", "B9", "B10", "B11", "B12", "B13", "B9", "B14" ]
19,321,500
pmid-9019810|pmid-11909525|pmid-7665619|pmid-11022043|pmid-9702200|pmid-10364159|pmid-11909525|pmid-16194295|pmid-18713834|pmid-17041189
Cap-dependent translation is a common mechanism in higher eukaryotes, which requires several factors.
[ "8", "9", "10", "11", "12", "13", "9", "14" ]
101
39,108
0
false
Cap-dependent translation is a common mechanism in higher eukaryotes, which requires several factors.
[]
Cap-dependent translation is a common mechanism in higher eukaryotes, which requires several factors.
true
true
true
true
true
6,735
1
INTRODUCTION
1
8
[ "B8", "B9", "B10", "B11", "B12", "B13", "B9", "B14" ]
19,321,500
pmid-9019810|pmid-11909525|pmid-7665619|pmid-11022043|pmid-9702200|pmid-10364159|pmid-11909525|pmid-16194295|pmid-18713834|pmid-17041189
The cap-binding complex, eIF4F, consists of three subunits, with eIF4G serving as a scaffold protein for the whole complex (8,9).
[ "8", "9", "10", "11", "12", "13", "9", "14" ]
129
39,109
0
false
The cap-binding complex, eIF4F, consists of three subunits, with eIF4G serving as a scaffold protein for the whole complex.
[ "8,9" ]
The cap-binding complex, eIF4F, consists of three subunits, with eIF4G serving as a scaffold protein for the whole complex.
true
true
true
true
true
6,735
1
INTRODUCTION
1
8
[ "B8", "B9", "B10", "B11", "B12", "B13", "B9", "B14" ]
19,321,500
pmid-9019810|pmid-11909525|pmid-7665619|pmid-11022043|pmid-9702200|pmid-10364159|pmid-11909525|pmid-16194295|pmid-18713834|pmid-17041189
eIF4G holds the cap-binding protein, eIF4E, and the ATP-dependent RNA helicase, eIF4A.
[ "8", "9", "10", "11", "12", "13", "9", "14" ]
86
39,110
0
false
eIF4G holds the cap-binding protein, eIF4E, and the ATP-dependent RNA helicase, eIF4A.
[]
eIF4G holds the cap-binding protein, eIF4E, and the ATP-dependent RNA helicase, eIF4A.
false
true
true
true
false
6,735
1
INTRODUCTION
1
8
[ "B8", "B9", "B10", "B11", "B12", "B13", "B9", "B14" ]
19,321,500
pmid-9019810|pmid-11909525|pmid-7665619|pmid-11022043|pmid-9702200|pmid-10364159|pmid-11909525|pmid-16194295|pmid-18713834|pmid-17041189
eIF4G also associates with eIF3 (10,11), a multisubunit factor that bridges the cap-binding complex and the small ribosomal subunit, as well as with the poly(A)-binding protein (PABP), which is found on the 3′-end of most eukaryotic mRNAs.
[ "8", "9", "10", "11", "12", "13", "9", "14" ]
239
39,111
0
false
eIF4G also associates with eIF3, a multisubunit factor that bridges the cap-binding complex and the small ribosomal subunit, as well as with the poly(A)-binding protein (PABP), which is found on the 3′-end of most eukaryotic mRNAs.
[ "10,11" ]
eIF4G also associates with eIF3, a multisubunit factor that bridges the cap-binding complex and the small ribosomal subunit, as well as with the poly(A)-binding protein (PABP), which is found on the 3′-end of most eukaryotic mRNAs.
false
true
true
true
false
6,735
1
INTRODUCTION
1
8
[ "B8", "B9", "B10", "B11", "B12", "B13", "B9", "B14" ]
19,321,500
pmid-9019810|pmid-11909525|pmid-7665619|pmid-11022043|pmid-9702200|pmid-10364159|pmid-11909525|pmid-16194295|pmid-18713834|pmid-17041189
These latter interactions allow the mRNA circularization, which is assumed to stimulate translation initiation (12,13).
[ "8", "9", "10", "11", "12", "13", "9", "14" ]
119
39,112
0
false
These latter interactions allow the mRNA circularization, which is assumed to stimulate translation initiation.
[ "12,13" ]
These latter interactions allow the mRNA circularization, which is assumed to stimulate translation initiation.
true
true
true
true
true
6,735
1
INTRODUCTION
1
8
[ "B8", "B9", "B10", "B11", "B12", "B13", "B9", "B14" ]
19,321,500
pmid-9019810|pmid-11909525|pmid-7665619|pmid-11022043|pmid-9702200|pmid-10364159|pmid-11909525|pmid-16194295|pmid-18713834|pmid-17041189
Assembly of the translation initiation complex on the 5′-mRNA cap structure (m7GTP) is rate-limiting and is therefore subject to strict regulation (9,14).
[ "8", "9", "10", "11", "12", "13", "9", "14" ]
154
39,113
0
false
Assembly of the translation initiation complex on the 5′-mRNA cap structure (m7GTP) is rate-limiting and is therefore subject to strict regulation.
[ "9,14" ]
Assembly of the translation initiation complex on the 5′-mRNA cap structure (m7GTP) is rate-limiting and is therefore subject to strict regulation.
true
true
true
true
true
6,735
2
INTRODUCTION
1
10
[ "B10", "B15", "B16", "B17", "B18", "B19", "B20", "B21", "B22", "B23", "B24", "B25" ]
19,321,500
pmid-7665619|pmid-9857202|pmid-9003792|pmid-10394359|pmid-14675538|pmid-9372926|pmid-11172724|pmid-16698552|pmid-16156639|pmid-11943866|pmid-18451872|pmid-18450493
The human eIF4G (1600 amino acids) possesses three domains that are defined by viral protease cleavage patterns (10).
[ "10", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25" ]
117
39,114
1
false
The human eIF4G possesses three domains that are defined by viral protease cleavage patterns.
[ "1600 amino acids", "10" ]
The human eIF4G possesses three domains that are defined by viral protease cleavage patterns.
true
true
true
true
true
6,736
2
INTRODUCTION
1
10
[ "B10", "B15", "B16", "B17", "B18", "B19", "B20", "B21", "B22", "B23", "B24", "B25" ]
19,321,500
pmid-7665619|pmid-9857202|pmid-9003792|pmid-10394359|pmid-14675538|pmid-9372926|pmid-11172724|pmid-16698552|pmid-16156639|pmid-11943866|pmid-18451872|pmid-18450493
The N-terminal segment includes eIF4E and PABP binding sites (15,16).
[ "10", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25" ]
69
39,115
0
false
The N-terminal segment includes eIF4E and PABP binding sites.
[ "15,16" ]
The N-terminal segment includes eIF4E and PABP binding sites.
true
true
true
true
true
6,736