Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
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 Community
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INTRODUCTION
1
1
[ "B1", "B2", "B2", "B1 B2 B3", "B1", "B3", "B4", "B5", "B2" ]
19,429,690
pmid-10871379|pmid-18657049|pmid-18657049|pmid-10871379|pmid-18657049|pmid-16282471|pmid-10871379|pmid-16282471|pmid-16343488|pmid-15705566|pmid-18657049|pmid-10871379|pmid-16282471|pmid-18657049
SMILE has been identified as an interacting partner of herpes simplex virus-related host-cell factor (HCF) and inhibits the replication of the herpes simplex virus (1,3).
[ "1", "2", "2", "1–3", "1", "3", "4", "5", "2" ]
170
38,816
0
false
SMILE has been identified as an interacting partner of herpes simplex virus-related host-cell factor (HCF) and inhibits the replication of the herpes simplex virus.
[ "1,3" ]
SMILE has been identified as an interacting partner of herpes simplex virus-related host-cell factor (HCF) and inhibits the replication of the herpes simplex virus.
true
true
true
true
true
6,683
0
INTRODUCTION
1
1
[ "B1", "B2", "B2", "B1 B2 B3", "B1", "B3", "B4", "B5", "B2" ]
19,429,690
pmid-10871379|pmid-18657049|pmid-18657049|pmid-10871379|pmid-18657049|pmid-16282471|pmid-10871379|pmid-16282471|pmid-16343488|pmid-15705566|pmid-18657049|pmid-10871379|pmid-16282471|pmid-18657049
SMILE has also been reported as a coactivator of ATF4 and as a corepressor of CREB3, another cellular HCF-binding transcription factor (4,5).
[ "1", "2", "2", "1–3", "1", "3", "4", "5", "2" ]
141
38,817
0
false
SMILE has also been reported as a coactivator of ATF4 and as a corepressor of CREB3, another cellular HCF-binding transcription factor.
[ "4,5" ]
SMILE has also been reported as a coactivator of ATF4 and as a corepressor of CREB3, another cellular HCF-binding transcription factor.
true
true
true
true
true
6,683
0
INTRODUCTION
1
2
[ "B1", "B2", "B2", "B1 B2 B3", "B1", "B3", "B4", "B5", "B2" ]
19,429,690
pmid-10871379|pmid-18657049|pmid-18657049|pmid-10871379|pmid-18657049|pmid-16282471|pmid-10871379|pmid-16282471|pmid-16343488|pmid-15705566|pmid-18657049|pmid-10871379|pmid-16282471|pmid-18657049
Recently, we have reported that SMILE acts as a coregulator of estrogen receptor (ER) signaling (2), but its role in other nuclear receptors (NRs) signaling remains unknown.
[ "1", "2", "2", "1–3", "1", "3", "4", "5", "2" ]
173
38,818
1
false
Recently, we have reported that SMILE acts as a coregulator of estrogen receptor (ER) signaling, but its role in other nuclear receptors (NRs) signaling remains unknown.
[ "2" ]
Recently, we have reported that SMILE acts as a coregulator of estrogen receptor (ER) signaling, but its role in other nuclear receptors (NRs) signaling remains unknown.
true
true
true
true
true
6,683
1
INTRODUCTION
1
6–8
[ "B6 B7 B8", "B8", "B8", "B9", "B10", "B11" ]
19,429,690
pmid-8076589|pmid-10529899|pmid-11729302|pmid-11729302|pmid-11729302|pmid-2647745|pmid-11562347|pmid-9369450|pmid-10871379|pmid-10871379|pmid-16282471|pmid-15705566|pmid-9192902|NA|pmid-16731568|pmid-2136830|pmid-12101239|pmid-15705566|pmid-10871379
NRs are transcription factors that modulate the expression of genes involved in embryonic development, maintenance of differentiated cellular phenotypes, metabolism and cell death [see references (6–8) for reviews].
[ "6–8", "8", "8", "9", "10", "11" ]
215
38,819
0
false
NRs are transcription factors that modulate the expression of genes involved in embryonic development, maintenance of differentiated cellular phenotypes, metabolism and cell death.
[ "see references (6–8) for reviews" ]
NRs are transcription factors that modulate the expression of genes involved in embryonic development, maintenance of differentiated cellular phenotypes, metabolism and cell death.
true
true
true
true
true
6,684
1
INTRODUCTION
1
8
[ "B6 B7 B8", "B8", "B8", "B9", "B10", "B11" ]
19,429,690
pmid-8076589|pmid-10529899|pmid-11729302|pmid-11729302|pmid-11729302|pmid-2647745|pmid-11562347|pmid-9369450|pmid-10871379|pmid-10871379|pmid-16282471|pmid-15705566|pmid-9192902|NA|pmid-16731568|pmid-2136830|pmid-12101239|pmid-15705566|pmid-10871379
Members of the NR superfamily include the conventional endocrine receptors, the adopted orphan receptors, for which ligands have been identified in recent years, and the orphan receptors, ligands of which have not yet been identified (8).
[ "6–8", "8", "8", "9", "10", "11" ]
238
38,820
1
false
Members of the NR superfamily include the conventional endocrine receptors, the adopted orphan receptors, for which ligands have been identified in recent years, and the orphan receptors, ligands of which have not yet been identified.
[ "8" ]
Members of the NR superfamily include the conventional endocrine receptors, the adopted orphan receptors, for which ligands have been identified in recent years, and the orphan receptors, ligands of which have not yet been identified.
true
true
true
true
true
6,684
1
INTRODUCTION
1
8
[ "B6 B7 B8", "B8", "B8", "B9", "B10", "B11" ]
19,429,690
pmid-8076589|pmid-10529899|pmid-11729302|pmid-11729302|pmid-11729302|pmid-2647745|pmid-11562347|pmid-9369450|pmid-10871379|pmid-10871379|pmid-16282471|pmid-15705566|pmid-9192902|NA|pmid-16731568|pmid-2136830|pmid-12101239|pmid-15705566|pmid-10871379
Glucocorticoid receptor (GR) is a member of steroid receptor family and mediates the effect of glucocorticoids in a variety of cellular processes, including homeostasis, cell growth, development, stress response and inflammation (8).
[ "6–8", "8", "8", "9", "10", "11" ]
233
38,821
1
false
Glucocorticoid receptor (GR) is a member of steroid receptor family and mediates the effect of glucocorticoids in a variety of cellular processes, including homeostasis, cell growth, development, stress response and inflammation.
[ "8" ]
Glucocorticoid receptor (GR) is a member of steroid receptor family and mediates the effect of glucocorticoids in a variety of cellular processes, including homeostasis, cell growth, development, stress response and inflammation.
true
true
true
true
true
6,684
1
INTRODUCTION
1
6–8
[ "B6 B7 B8", "B8", "B8", "B9", "B10", "B11" ]
19,429,690
pmid-8076589|pmid-10529899|pmid-11729302|pmid-11729302|pmid-11729302|pmid-2647745|pmid-11562347|pmid-9369450|pmid-10871379|pmid-10871379|pmid-16282471|pmid-15705566|pmid-9192902|NA|pmid-16731568|pmid-2136830|pmid-12101239|pmid-15705566|pmid-10871379
GR regulates the transcription of target genes either by binding to specific glucocorticoid response elements (GREs) within the target genes or by interacting with other DNA-bound transcription factors.
[ "6–8", "8", "8", "9", "10", "11" ]
202
38,822
0
false
GR regulates the transcription of target genes either by binding to specific glucocorticoid response elements (GREs) within the target genes or by interacting with other DNA-bound transcription factors.
[]
GR regulates the transcription of target genes either by binding to specific glucocorticoid response elements (GREs) within the target genes or by interacting with other DNA-bound transcription factors.
true
true
true
true
true
6,684
1
INTRODUCTION
1
6–8
[ "B6 B7 B8", "B8", "B8", "B9", "B10", "B11" ]
19,429,690
pmid-8076589|pmid-10529899|pmid-11729302|pmid-11729302|pmid-11729302|pmid-2647745|pmid-11562347|pmid-9369450|pmid-10871379|pmid-10871379|pmid-16282471|pmid-15705566|pmid-9192902|NA|pmid-16731568|pmid-2136830|pmid-12101239|pmid-15705566|pmid-10871379
The inactive GR resides in the cytoplasm bound to heat-shock protein.
[ "6–8", "8", "8", "9", "10", "11" ]
69
38,823
0
false
The inactive GR resides in the cytoplasm bound to heat-shock protein.
[]
The inactive GR resides in the cytoplasm bound to heat-shock protein.
true
true
true
true
true
6,684
1
INTRODUCTION
1
9
[ "B6 B7 B8", "B8", "B8", "B9", "B10", "B11" ]
19,429,690
pmid-8076589|pmid-10529899|pmid-11729302|pmid-11729302|pmid-11729302|pmid-2647745|pmid-11562347|pmid-9369450|pmid-10871379|pmid-10871379|pmid-16282471|pmid-15705566|pmid-9192902|NA|pmid-16731568|pmid-2136830|pmid-12101239|pmid-15705566|pmid-10871379
It dissociates from heat-shock protein upon ligand binding and enters the nucleus where it functions as a transcription factor (9).
[ "6–8", "8", "8", "9", "10", "11" ]
131
38,824
1
false
It dissociates from heat-shock protein upon ligand binding and enters the nucleus where it functions as a transcription factor.
[ "9" ]
It dissociates from heat-shock protein upon ligand binding and enters the nucleus where it functions as a transcription factor.
true
true
true
true
true
6,684
1
INTRODUCTION
1
6–8
[ "B6 B7 B8", "B8", "B8", "B9", "B10", "B11" ]
19,429,690
pmid-8076589|pmid-10529899|pmid-11729302|pmid-11729302|pmid-11729302|pmid-2647745|pmid-11562347|pmid-9369450|pmid-10871379|pmid-10871379|pmid-16282471|pmid-15705566|pmid-9192902|NA|pmid-16731568|pmid-2136830|pmid-12101239|pmid-15705566|pmid-10871379
GR plays an important role in various metabolic pathways by regulating the expression of genes such as phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (G6Pase) and insulin-like growth factor-binding protein 1 (IGFBP1) (10,11).
[ "6–8", "8", "8", "9", "10", "11" ]
243
38,825
0
false
GR plays an important role in various metabolic pathways by regulating the expression of genes such as phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (G6Pase) and insulin-like growth factor-binding protein 1 (IGFBP1).
[ "10,11" ]
GR plays an important role in various metabolic pathways by regulating the expression of genes such as phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase and insulin-like growth factor-binding protein 1 (IGFBP1).
true
true
true
true
true
6,684
2
INTRODUCTION
1
8
[ "B8", "B12", "B13", "B12 B13 B14", "B6", "B7", "B7", "B15", "B16 B17 B18", "B7" ]
19,429,690
pmid-11729302|pmid-10037683|pmid-15004031|pmid-10037683|pmid-15004031|pmid-17284330|pmid-8076589|pmid-10529899|pmid-10529899|pmid-12774000|pmid-10194766|pmid-10627496|pmid-12107181|pmid-10529899|pmid-9192902|NA|pmid-17068076|pmid-10531331
Constitutive androstane receptor (CAR) is an adopted orphan NR which functions as heterodimers with the retinoid X receptor (RXR) (8).
[ "8", "12", "13", "12–14", "6", "7", "7", "15", "16–18", "7" ]
134
38,826
1
false
Constitutive androstane receptor (CAR) is an adopted orphan NR which functions as heterodimers with the retinoid X receptor (RXR).
[ "8" ]
Constitutive androstane receptor (CAR) is an adopted orphan NR which functions as heterodimers with the retinoid X receptor (RXR).
true
true
true
true
true
6,685
2
INTRODUCTION
1
8
[ "B8", "B12", "B13", "B12 B13 B14", "B6", "B7", "B7", "B15", "B16 B17 B18", "B7" ]
19,429,690
pmid-11729302|pmid-10037683|pmid-15004031|pmid-10037683|pmid-15004031|pmid-17284330|pmid-8076589|pmid-10529899|pmid-10529899|pmid-12774000|pmid-10194766|pmid-10627496|pmid-12107181|pmid-10529899|pmid-9192902|NA|pmid-17068076|pmid-10531331
CAR evidences constitutive activity, and is expressed primarily in the liver, where it regulates many Phase I and Phase II biotransforming enzymes, including Cyp2b6, Sult2a1, SultN and Ugt1a1 (12,13).
[ "8", "12", "13", "12–14", "6", "7", "7", "15", "16–18", "7" ]
200
38,827
0
false
CAR evidences constitutive activity, and is expressed primarily in the liver, where it regulates many Phase I and Phase II biotransforming enzymes, including Cyp2b6, Sult2a1, SultN and Ugt1a1.
[ "12,13" ]
CAR evidences constitutive activity, and is expressed primarily in the liver, where it regulates many Phase I and Phase II biotransforming enzymes, including Cyp2b6, Sult2a1, SultN and Ugt1a1.
true
true
true
true
true
6,685
2
INTRODUCTION
1
8
[ "B8", "B12", "B13", "B12 B13 B14", "B6", "B7", "B7", "B15", "B16 B17 B18", "B7" ]
19,429,690
pmid-11729302|pmid-10037683|pmid-15004031|pmid-10037683|pmid-15004031|pmid-17284330|pmid-8076589|pmid-10529899|pmid-10529899|pmid-12774000|pmid-10194766|pmid-10627496|pmid-12107181|pmid-10529899|pmid-9192902|NA|pmid-17068076|pmid-10531331
This xenobiotic receptor can also regulate the expression of membrane transporter proteins such as organic anion transporting peptide 2 (Oatp2) and multidrug resistance-associated proteins.
[ "8", "12", "13", "12–14", "6", "7", "7", "15", "16–18", "7" ]
189
38,828
0
false
This xenobiotic receptor can also regulate the expression of membrane transporter proteins such as organic anion transporting peptide 2 (Oatp2) and multidrug resistance-associated proteins.
[]
This xenobiotic receptor can also regulate the expression of membrane transporter proteins such as organic anion transporting peptide 2 (Oatp2) and multidrug resistance-associated proteins.
true
true
true
true
true
6,685
2
INTRODUCTION
1
12–14
[ "B8", "B12", "B13", "B12 B13 B14", "B6", "B7", "B7", "B15", "B16 B17 B18", "B7" ]
19,429,690
pmid-11729302|pmid-10037683|pmid-15004031|pmid-10037683|pmid-15004031|pmid-17284330|pmid-8076589|pmid-10529899|pmid-10529899|pmid-12774000|pmid-10194766|pmid-10627496|pmid-12107181|pmid-10529899|pmid-9192902|NA|pmid-17068076|pmid-10531331
CAR can be modulated by structurally diverse chemicals such as 1,4-bis-2[-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) and phenobarbital (12–14).
[ "8", "12", "13", "12–14", "6", "7", "7", "15", "16–18", "7" ]
143
38,829
1
false
CAR can be modulated by structurally diverse chemicals such as 1,4-bis-2[-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) and phenobarbital.
[ "12–14" ]
CAR can be modulated by structurally diverse chemicals such as 1,4-bis-2[-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) and phenobarbital.
true
true
true
true
true
6,685
2
INTRODUCTION
1
8
[ "B8", "B12", "B13", "B12 B13 B14", "B6", "B7", "B7", "B15", "B16 B17 B18", "B7" ]
19,429,690
pmid-11729302|pmid-10037683|pmid-15004031|pmid-10037683|pmid-15004031|pmid-17284330|pmid-8076589|pmid-10529899|pmid-10529899|pmid-12774000|pmid-10194766|pmid-10627496|pmid-12107181|pmid-10529899|pmid-9192902|NA|pmid-17068076|pmid-10531331
Hepatocyte nuclear factor 4 (HNF4) is an orphan nuclear receptor which is highly expressed in the liver, kidney, and pancreatic Ξ²-cells.
[ "8", "12", "13", "12–14", "6", "7", "7", "15", "16–18", "7" ]
136
38,830
0
false
Hepatocyte nuclear factor 4 (HNF4) is an orphan nuclear receptor which is highly expressed in the liver, kidney, and pancreatic Ξ²-cells.
[]
Hepatocyte nuclear factor 4 (HNF4) is an orphan nuclear receptor which is highly expressed in the liver, kidney, and pancreatic Ξ²-cells.
true
true
true
true
true
6,685
2
INTRODUCTION
1
8
[ "B8", "B12", "B13", "B12 B13 B14", "B6", "B7", "B7", "B15", "B16 B17 B18", "B7" ]
19,429,690
pmid-11729302|pmid-10037683|pmid-15004031|pmid-10037683|pmid-15004031|pmid-17284330|pmid-8076589|pmid-10529899|pmid-10529899|pmid-12774000|pmid-10194766|pmid-10627496|pmid-12107181|pmid-10529899|pmid-9192902|NA|pmid-17068076|pmid-10531331
HNF4 contains two subtypes in mammals, namely HNF4Ξ± and HNF4Ξ³, and binds to the DR-1 element of target gene promoters as homodimers (6,7).
[ "8", "12", "13", "12–14", "6", "7", "7", "15", "16–18", "7" ]
138
38,831
0
false
HNF4 contains two subtypes in mammals, namely HNF4Ξ± and HNF4Ξ³, and binds to the DR-1 element of target gene promoters as homodimers.
[ "6,7" ]
HNF4 contains two subtypes in mammals, namely HNF4Ξ± and HNF4Ξ³, and binds to the DR-1 element of target gene promoters as homodimers.
true
true
true
true
true
6,685
2
INTRODUCTION
1
16–18
[ "B8", "B12", "B13", "B12 B13 B14", "B6", "B7", "B7", "B15", "B16 B17 B18", "B7" ]
19,429,690
pmid-11729302|pmid-10037683|pmid-15004031|pmid-10037683|pmid-15004031|pmid-17284330|pmid-8076589|pmid-10529899|pmid-10529899|pmid-12774000|pmid-10194766|pmid-10627496|pmid-12107181|pmid-10529899|pmid-9192902|NA|pmid-17068076|pmid-10531331
HNF4Ξ± plays critical roles not only in the specification of the hepatic phenotype during liver development but also in the transcriptional regulation of genes involved in glucose, cholesterol, fatty acids and xenobiotic metabolism (7,15), including PEPCK, cholesterol 7 alpha-hydroxylase (CYP7A1) and liver carnitine pal...
[ "8", "12", "13", "12–14", "6", "7", "7", "15", "16–18", "7" ]
359
38,832
1
false
HNF4Ξ± plays critical roles not only in the specification of the hepatic phenotype during liver development but also in the transcriptional regulation of genes involved in glucose, cholesterol, fatty acids and xenobiotic metabolism, including PEPCK, cholesterol 7 alpha-hydroxylase and liver carnitine palmitoyl transfera...
[ "7,15", "CYP7A1", "16–18" ]
HNF4Ξ± plays critical roles not only in the specification of the hepatic phenotype during liver development but also in the transcriptional regulation of genes involved in glucose, cholesterol, fatty acids and xenobiotic metabolism, including PEPCK, cholesterol 7 alpha-hydroxylase and liver carnitine palmitoyl transfera...
true
true
true
true
true
6,685
2
INTRODUCTION
1
7
[ "B8", "B12", "B13", "B12 B13 B14", "B6", "B7", "B7", "B15", "B16 B17 B18", "B7" ]
19,429,690
pmid-11729302|pmid-10037683|pmid-15004031|pmid-10037683|pmid-15004031|pmid-17284330|pmid-8076589|pmid-10529899|pmid-10529899|pmid-12774000|pmid-10194766|pmid-10627496|pmid-12107181|pmid-10529899|pmid-9192902|NA|pmid-17068076|pmid-10531331
Mutations in the HNF4Ξ± gene have been associated with maturity-onset diabetes of the young (MODY) (7).
[ "8", "12", "13", "12–14", "6", "7", "7", "15", "16–18", "7" ]
102
38,833
1
false
Mutations in the HNF4Ξ± gene have been associated with maturity-onset diabetes of the young (MODY).
[ "7" ]
Mutations in the HNF4Ξ± gene have been associated with maturity-onset diabetes of the young (MODY).
true
true
true
true
true
6,685
3
INTRODUCTION
1
19
[ "B19", "B20", "B21 B22 B23 B24", "B25", "B26" ]
19,429,690
pmid-17803935|pmid-15957004|pmid-12145209|pmid-11909518|pmid-11343897|pmid-16751179|pmid-9192902|pmid-11459854|pmid-18657049|pmid-18657049
NR-mediated transcriptional effects are regulated by NR coregulators, including coactivators and corepressor (19).
[ "19", "20", "21–24", "25", "26" ]
114
38,834
1
false
NR-mediated transcriptional effects are regulated by NR coregulators, including coactivators and corepressor.
[ "19" ]
NR-mediated transcriptional effects are regulated by NR coregulators, including coactivators and corepressor.
true
true
true
true
true
6,686
3
INTRODUCTION
1
20
[ "B19", "B20", "B21 B22 B23 B24", "B25", "B26" ]
19,429,690
pmid-17803935|pmid-15957004|pmid-12145209|pmid-11909518|pmid-11343897|pmid-16751179|pmid-9192902|pmid-11459854|pmid-18657049|pmid-18657049
Coregulators modulate the transcription of NR target genes through taking part in chromatin remodeling or interacting with basal transcriptional machinery to influence the main steps in transcriptional initiation (20).
[ "19", "20", "21–24", "25", "26" ]
218
38,835
1
false
Coregulators modulate the transcription of NR target genes through taking part in chromatin remodeling or interacting with basal transcriptional machinery to influence the main steps in transcriptional initiation.
[ "20" ]
Coregulators modulate the transcription of NR target genes through taking part in chromatin remodeling or interacting with basal transcriptional machinery to influence the main steps in transcriptional initiation.
true
true
true
true
true
6,686
3
INTRODUCTION
1
21–24
[ "B19", "B20", "B21 B22 B23 B24", "B25", "B26" ]
19,429,690
pmid-17803935|pmid-15957004|pmid-12145209|pmid-11909518|pmid-11343897|pmid-16751179|pmid-9192902|pmid-11459854|pmid-18657049|pmid-18657049
In the presence of NR ligands, the SWI/SNF chromatin remodeling complex, the histone acetyltransferase (HAT) activity containing complexes CBP/p160/P/CAF, and the TRAP/DRIP/ARC complex are sequentially recruited to gene promoters to activate gene transcription (21–24).
[ "19", "20", "21–24", "25", "26" ]
269
38,836
1
false
In the presence of NR ligands, the SWI/SNF chromatin remodeling complex, the histone acetyltransferase (HAT) activity containing complexes CBP/p160/P/CAF, and the TRAP/DRIP/ARC complex are sequentially recruited to gene promoters to activate gene transcription.
[ "21–24" ]
In the presence of NR ligands, the SWI/SNF chromatin remodeling complex, the histone acetyltransferase (HAT) activity containing complexes CBP/p160/P/CAF, and the TRAP/DRIP/ARC complex are sequentially recruited to gene promoters to activate gene transcription.
true
true
true
true
true
6,686
3
INTRODUCTION
1
25
[ "B19", "B20", "B21 B22 B23 B24", "B25", "B26" ]
19,429,690
pmid-17803935|pmid-15957004|pmid-12145209|pmid-11909518|pmid-11343897|pmid-16751179|pmid-9192902|pmid-11459854|pmid-18657049|pmid-18657049
Coactivators of the p160 family, including SRC1/NCoA1 and TIF-2/GRIP1, interact with the ligand-binding domain (LBD)/activation function 2 (AF2) domain of receptors through an LXXLL motif or NR boxes (25).
[ "19", "20", "21–24", "25", "26" ]
205
38,837
1
false
Coactivators of the p160 family, including SRC1/NCoA1 and TIF-2/GRIP1, interact with the ligand-binding domain (LBD)/activation function 2 (AF2) domain of receptors through an LXXLL motif or NR boxes.
[ "25" ]
Coactivators of the p160 family, including SRC1/NCoA1 and TIF-2/GRIP1, interact with the ligand-binding domain (LBD)/activation function 2 domain of receptors through an LXXLL motif or NR boxes.
true
true
true
true
true
6,686
3
INTRODUCTION
1
19
[ "B19", "B20", "B21 B22 B23 B24", "B25", "B26" ]
19,429,690
pmid-17803935|pmid-15957004|pmid-12145209|pmid-11909518|pmid-11343897|pmid-16751179|pmid-9192902|pmid-11459854|pmid-18657049|pmid-18657049
In the absence of NR ligands, on the other hand, many NRs prevent gene transcription via recruitment of corepressors such as N-CoR and SMRT, which have been proposed to antagonize the actions of coactivators and to maintain a more repressed state in the chromatin structure.
[ "19", "20", "21–24", "25", "26" ]
274
38,838
0
false
In the absence of NR ligands, on the other hand, many NRs prevent gene transcription via recruitment of corepressors such as N-CoR and SMRT, which have been proposed to antagonize the actions of coactivators and to maintain a more repressed state in the chromatin structure.
[]
In the absence of NR ligands, on the other hand, many NRs prevent gene transcription via recruitment of corepressors such as N-CoR and SMRT, which have been proposed to antagonize the actions of coactivators and to maintain a more repressed state in the chromatin structure.
true
true
true
true
true
6,686
3
INTRODUCTION
1
26
[ "B19", "B20", "B21 B22 B23 B24", "B25", "B26" ]
19,429,690
pmid-17803935|pmid-15957004|pmid-12145209|pmid-11909518|pmid-11343897|pmid-16751179|pmid-9192902|pmid-11459854|pmid-18657049|pmid-18657049
Histone deacetylases (HDACs)-dependent and HDACs-independent mechanisms are involved in the transrepression induced by N-CoR and SMRT (26).
[ "19", "20", "21–24", "25", "26" ]
139
38,839
1
false
Histone deacetylases (HDACs)-dependent and HDACs-independent mechanisms are involved in the transrepression induced by N-CoR and SMRT.
[ "26" ]
Histone deacetylases (HDACs)-dependent and HDACs-independent mechanisms are involved in the transrepression induced by N-CoR and SMRT.
true
true
true
true
true
6,686
4
INTRODUCTION
0
null
null
19,429,690
pmid-14752053|pmid-18381063|NA|pmid-12535528|pmid-15835920|pmid-15060175|pmid-15060175|pmid-12535528|pmid-11459854
In this study, we have identified that SMILE represses the transcriptional activities of GR, CAR and HNF4Ξ± through direct interaction.
null
134
38,840
0
false
null
null
In this study, we have identified that SMILE represses the transcriptional activities of GR, CAR and HNF4Ξ± through direct interaction.
true
true
true
true
true
6,687
4
INTRODUCTION
0
null
null
19,429,690
pmid-14752053|pmid-18381063|NA|pmid-12535528|pmid-15835920|pmid-15060175|pmid-15060175|pmid-12535528|pmid-11459854
We have demonstrated that SMILE represses the transactivities of the NRs via competition with coactivators and the recruitment of HDACs for its active repression.
null
162
38,841
0
false
null
null
We have demonstrated that SMILE represses the transactivities of the NRs via competition with coactivators and the recruitment of HDACs for its active repression.
true
true
true
true
true
6,687
4
INTRODUCTION
0
null
null
19,429,690
pmid-14752053|pmid-18381063|NA|pmid-12535528|pmid-15835920|pmid-15060175|pmid-15060175|pmid-12535528|pmid-11459854
Overall, our findings suggest that SMILE acts as a novel corepressor of NRs.
null
76
38,842
0
false
null
null
Overall, our findings suggest that SMILE acts as a novel corepressor of NRs.
true
true
true
true
true
6,687
0
DISCUSSION
1
2
[ "B1", "B3", "B2" ]
19,429,690
pmid-10871379|pmid-18657049|pmid-18657049|pmid-10871379|pmid-18657049|pmid-16282471|pmid-10871379|pmid-16282471|pmid-16343488|pmid-15705566|pmid-18657049|pmid-10871379|pmid-16282471|pmid-18657049
Previous results have demonstrated that the bZIP protein SMILE plays an important role in repressing the replication of the herpes simplex virus (1,3) and serves as a coregulator in ER signaling (2).
[ "1", "3", "2" ]
199
38,843
1
false
Previous results have demonstrated that the bZIP protein SMILE plays an important role in repressing the replication of the herpes simplex virus and serves as a coregulator in ER signaling.
[ "1,3", "2" ]
Previous results have demonstrated that the bZIP protein SMILE plays an important role in repressing the replication of the herpes simplex virus and serves as a coregulator in ER signaling.
true
true
true
true
true
6,688
0
DISCUSSION
1
1
[ "B1", "B3", "B2" ]
19,429,690
pmid-10871379|pmid-18657049|pmid-18657049|pmid-10871379|pmid-18657049|pmid-16282471|pmid-10871379|pmid-16282471|pmid-16343488|pmid-15705566|pmid-18657049|pmid-10871379|pmid-16282471|pmid-18657049
The results presented in this study extend the role of SMILE in NR signaling.
[ "1", "3", "2" ]
77
38,844
0
false
The results presented in this study extend the role of SMILE in NR signaling.
[]
The results presented in this study extend the role of SMILE in NR signaling.
true
true
true
true
true
6,688
0
DISCUSSION
1
1
[ "B1", "B3", "B2" ]
19,429,690
pmid-10871379|pmid-18657049|pmid-18657049|pmid-10871379|pmid-18657049|pmid-16282471|pmid-10871379|pmid-16282471|pmid-16343488|pmid-15705566|pmid-18657049|pmid-10871379|pmid-16282471|pmid-18657049
SMILE inhibited GR-, HNF4Ξ±- and CAR-mediated transcriptional activity through direct binding to the LBD/AF2 domain of the NRs.
[ "1", "3", "2" ]
126
38,845
0
false
SMILE inhibited GR-, HNF4Ξ±- and CAR-mediated transcriptional activity through direct binding to the LBD/AF2 domain of the NRs.
[]
SMILE inhibited GR-, HNF4Ξ±- and CAR-mediated transcriptional activity through direct binding to the LBD/AF2 domain of the NRs.
true
true
true
true
true
6,688
0
DISCUSSION
1
1
[ "B1", "B3", "B2" ]
19,429,690
pmid-10871379|pmid-18657049|pmid-18657049|pmid-10871379|pmid-18657049|pmid-16282471|pmid-10871379|pmid-16282471|pmid-16343488|pmid-15705566|pmid-18657049|pmid-10871379|pmid-16282471|pmid-18657049
Moreover, the knockdown of SMILE gene expression increased the GR, HNF4Ξ± and CAR transactivation.
[ "1", "3", "2" ]
97
38,846
0
false
Moreover, the knockdown of SMILE gene expression increased the GR, HNF4Ξ± and CAR transactivation.
[]
Moreover, the knockdown of SMILE gene expression increased the GR, HNF4Ξ± and CAR transactivation.
true
true
true
true
true
6,688
0
DISCUSSION
1
1
[ "B1", "B3", "B2" ]
19,429,690
pmid-10871379|pmid-18657049|pmid-18657049|pmid-10871379|pmid-18657049|pmid-16282471|pmid-10871379|pmid-16282471|pmid-16343488|pmid-15705566|pmid-18657049|pmid-10871379|pmid-16282471|pmid-18657049
Furthermore, the overexpression of SMILE via adenovirus vector inhibited the transcription of the NRs’ target genes, including IGFBP-1, CYP2B6 and CYP7A1.
[ "1", "3", "2" ]
154
38,847
0
false
Furthermore, the overexpression of SMILE via adenovirus vector inhibited the transcription of the NRs’ target genes, including IGFBP-1, CYP2B6 and CYP7A1.
[]
Furthermore, the overexpression of SMILE via adenovirus vector inhibited the transcription of the NRs’ target genes, including IGFBP-1, CYP2B6 and CYP7A1.
true
true
true
true
true
6,688
0
DISCUSSION
1
1
[ "B1", "B3", "B2" ]
19,429,690
pmid-10871379|pmid-18657049|pmid-18657049|pmid-10871379|pmid-18657049|pmid-16282471|pmid-10871379|pmid-16282471|pmid-16343488|pmid-15705566|pmid-18657049|pmid-10871379|pmid-16282471|pmid-18657049
In addition, SMILE also inhibited the transactivation by receptor LXR, FXR, Nur77 and ERRΞ³ through direct interactions (data not shown).
[ "1", "3", "2" ]
136
38,848
0
false
In addition, SMILE also inhibited the transactivation by receptor LXR, FXR, Nur77 and ERRΞ³ through direct interactions (data not shown).
[]
In addition, SMILE also inhibited the transactivation by receptor LXR, FXR, Nur77 and ERRΞ³ through direct interactions (data not shown).
true
true
true
true
true
6,688
0
DISCUSSION
1
1
[ "B1", "B3", "B2" ]
19,429,690
pmid-10871379|pmid-18657049|pmid-18657049|pmid-10871379|pmid-18657049|pmid-16282471|pmid-10871379|pmid-16282471|pmid-16343488|pmid-15705566|pmid-18657049|pmid-10871379|pmid-16282471|pmid-18657049
These findings indicate that SMILE may be an important modulator of NR signaling.
[ "1", "3", "2" ]
81
38,849
0
false
These findings indicate that SMILE may be an important modulator of NR signaling.
[]
These findings indicate that SMILE may be an important modulator of NR signaling.
true
true
true
true
true
6,688
1
DISCUSSION
1
1
[ "B1", "B1", "B3", "B5", "B25", "B43", "B44", "B35", "B45", "B5", "B1" ]
19,429,690
pmid-8076589|pmid-10529899|pmid-11729302|pmid-11729302|pmid-11729302|pmid-2647745|pmid-11562347|pmid-9369450|pmid-10871379|pmid-10871379|pmid-16282471|pmid-15705566|pmid-9192902|NA|pmid-16731568|pmid-2136830|pmid-12101239|pmid-15705566|pmid-10871379
We have investigated the roles of potential functional domains of SMILE for its repressive function, including the leucine zipper motif (1), the HCF-binding motif (HBM) (1,3,5) and the LXXLL motifs (NR boxes) (25,43).
[ "1", "1", "3", "5", "25", "43", "44", "35", "45", "5", "1" ]
217
38,850
1
false
We have investigated the roles of potential functional domains of SMILE for its repressive function, including the leucine zipper motif, the HCF-binding motif (HBM) and the LXXLL motifs (NR boxes).
[ "1", "1,3,5", "25,43" ]
We have investigated the roles of potential functional domains of SMILE for its repressive function, including the leucine zipper motif, the HCF-binding motif (HBM) and the LXXLL motifs (NR boxes).
true
true
true
true
true
6,689
1
DISCUSSION
1
44
[ "B1", "B1", "B3", "B5", "B25", "B43", "B44", "B35", "B45", "B5", "B1" ]
19,429,690
pmid-8076589|pmid-10529899|pmid-11729302|pmid-11729302|pmid-11729302|pmid-2647745|pmid-11562347|pmid-9369450|pmid-10871379|pmid-10871379|pmid-16282471|pmid-15705566|pmid-9192902|NA|pmid-16731568|pmid-2136830|pmid-12101239|pmid-15705566|pmid-10871379
The leucine zipper region is known to be essential for the dimerization and functions of b-zip proteins (44).
[ "1", "1", "3", "5", "25", "43", "44", "35", "45", "5", "1" ]
109
38,851
1
false
The leucine zipper region is known to be essential for the dimerization and functions of b-zip proteins.
[ "44" ]
The leucine zipper region is known to be essential for the dimerization and functions of b-zip proteins.
true
true
true
true
true
6,689
1
DISCUSSION
1
35
[ "B1", "B1", "B3", "B5", "B25", "B43", "B44", "B35", "B45", "B5", "B1" ]
19,429,690
pmid-8076589|pmid-10529899|pmid-11729302|pmid-11729302|pmid-11729302|pmid-2647745|pmid-11562347|pmid-9369450|pmid-10871379|pmid-10871379|pmid-16282471|pmid-15705566|pmid-9192902|NA|pmid-16731568|pmid-2136830|pmid-12101239|pmid-15705566|pmid-10871379
For instance, the leucine zipper of cyclic AMP response element-binding (CREB) protein is required for the dimerization and transcriptional activation (35).
[ "1", "1", "3", "5", "25", "43", "44", "35", "45", "5", "1" ]
156
38,852
1
false
For instance, the leucine zipper of cyclic AMP response element-binding (CREB) protein is required for the dimerization and transcriptional activation.
[ "35" ]
For instance, the leucine zipper of cyclic AMP response element-binding (CREB) protein is required for the dimerization and transcriptional activation.
true
true
true
true
true
6,689
1
DISCUSSION
1
1
[ "B1", "B1", "B3", "B5", "B25", "B43", "B44", "B35", "B45", "B5", "B1" ]
19,429,690
pmid-8076589|pmid-10529899|pmid-11729302|pmid-11729302|pmid-11729302|pmid-2647745|pmid-11562347|pmid-9369450|pmid-10871379|pmid-10871379|pmid-16282471|pmid-15705566|pmid-9192902|NA|pmid-16731568|pmid-2136830|pmid-12101239|pmid-15705566|pmid-10871379
By way of contrast, our findings support the notion that the bZIP region of SMILE is required for the homodimerization, but is not essential for the repressive effect of SMILE on GR and CAR (Figure 4).
[ "1", "1", "3", "5", "25", "43", "44", "35", "45", "5", "1" ]
201
38,853
0
false
By way of contrast, our findings support the notion that the bZIP region of SMILE is required for the homodimerization, but is not essential for the repressive effect of SMILE on GR and CAR (Figure 4).
[]
By way of contrast, our findings support the notion that the bZIP region of SMILE is required for the homodimerization, but is not essential for the repressive effect of SMILE on GR and CAR (Figure 4).
true
true
true
true
true
6,689
1
DISCUSSION
1
45
[ "B1", "B1", "B3", "B5", "B25", "B43", "B44", "B35", "B45", "B5", "B1" ]
19,429,690
pmid-8076589|pmid-10529899|pmid-11729302|pmid-11729302|pmid-11729302|pmid-2647745|pmid-11562347|pmid-9369450|pmid-10871379|pmid-10871379|pmid-16282471|pmid-15705566|pmid-9192902|NA|pmid-16731568|pmid-2136830|pmid-12101239|pmid-15705566|pmid-10871379
It has been reported that Jun dimerization protein 2 (JDP-2) functions as a progesterone receptor (PR) coactivator through direct interaction via the DBD of PR and the bZIP region of JDP-2 (45).
[ "1", "1", "3", "5", "25", "43", "44", "35", "45", "5", "1" ]
194
38,854
1
false
It has been reported that Jun dimerization protein 2 (JDP-2) functions as a progesterone receptor (PR) coactivator through direct interaction via the DBD of PR and the bZIP region of JDP-2.
[ "45" ]
It has been reported that Jun dimerization protein 2 (JDP-2) functions as a progesterone receptor (PR) coactivator through direct interaction via the DBD of PR and the bZIP region of JDP-2.
true
true
true
true
true
6,689
1
DISCUSSION
1
1
[ "B1", "B1", "B3", "B5", "B25", "B43", "B44", "B35", "B45", "B5", "B1" ]
19,429,690
pmid-8076589|pmid-10529899|pmid-11729302|pmid-11729302|pmid-11729302|pmid-2647745|pmid-11562347|pmid-9369450|pmid-10871379|pmid-10871379|pmid-16282471|pmid-15705566|pmid-9192902|NA|pmid-16731568|pmid-2136830|pmid-12101239|pmid-15705566|pmid-10871379
However, the domain-mapping results have demonstrated that the bZIP region of SMILE is not involved in the interactions with GR, CAR and HNF4Ξ± (Figure 5).
[ "1", "1", "3", "5", "25", "43", "44", "35", "45", "5", "1" ]
154
38,855
0
false
However, the domain-mapping results have demonstrated that the bZIP region of SMILE is not involved in the interactions with GR, CAR and HNF4Ξ±.
[ "Figure 5" ]
However, the domain-mapping results have demonstrated that the bZIP region of SMILE is not involved in the interactions with GR, CAR and HNF4Ξ±.
true
true
true
true
true
6,689
1
DISCUSSION
1
1
[ "B1", "B1", "B3", "B5", "B25", "B43", "B44", "B35", "B45", "B5", "B1" ]
19,429,690
pmid-8076589|pmid-10529899|pmid-11729302|pmid-11729302|pmid-11729302|pmid-2647745|pmid-11562347|pmid-9369450|pmid-10871379|pmid-10871379|pmid-16282471|pmid-15705566|pmid-9192902|NA|pmid-16731568|pmid-2136830|pmid-12101239|pmid-15705566|pmid-10871379
Although HBM-mediated association of SMILE with HCF is required for SMILE to repress CREB3 (5), our reporter assay results have shown that wild-type SMILE and HBM-defective SMILE mutant (Y306A), which was demonstrated not able to interact with HCF (1), have similar inhibitory effect on GR, CAR and HNF4Ξ± (Supplementary ...
[ "1", "1", "3", "5", "25", "43", "44", "35", "45", "5", "1" ]
399
38,856
1
false
Although HBM-mediated association of SMILE with HCF is required for SMILE to repress CREB3, our reporter assay results have shown that wild-type SMILE and HBM-defective SMILE mutant, which was demonstrated not able to interact with HCF, have similar inhibitory effect on GR, CAR and HNF4Ξ±, indicating the repression of t...
[ "5", "Y306A", "1", "Supplementary Figure 1" ]
Although HBM-mediated association of SMILE with HCF is required for SMILE to repress CREB3, our reporter assay results have shown that wild-type SMILE and HBM-defective SMILE mutant, which was demonstrated not able to interact with HCF, have similar inhibitory effect on GR, CAR and HNF4Ξ±, indicating the repression of t...
true
true
true
true
true
6,689
2
DISCUSSION
1
25
[ "B25", "B43", "B46", "B40" ]
19,429,690
pmid-11729302|pmid-10037683|pmid-15004031|pmid-10037683|pmid-15004031|pmid-17284330|pmid-8076589|pmid-10529899|pmid-10529899|pmid-12774000|pmid-10194766|pmid-10627496|pmid-12107181|pmid-10529899|pmid-9192902|NA|pmid-17068076|pmid-10531331
LXXLL motif is commonly found in NR coregultors and has been reported to be important for coregulators function through interaction with the LBD/AF2 domain of NRs (25,43).
[ "25", "43", "46", "40" ]
171
38,857
0
false
LXXLL motif is commonly found in NR coregultors and has been reported to be important for coregulators function through interaction with the LBD/AF2 domain of NRs.
[ "25,43" ]
LXXLL motif is commonly found in NR coregultors and has been reported to be important for coregulators function through interaction with the LBD/AF2 domain of NRs.
true
true
true
true
true
6,690
2
DISCUSSION
1
25
[ "B25", "B43", "B46", "B40" ]
19,429,690
pmid-11729302|pmid-10037683|pmid-15004031|pmid-10037683|pmid-15004031|pmid-17284330|pmid-8076589|pmid-10529899|pmid-10529899|pmid-12774000|pmid-10194766|pmid-10627496|pmid-12107181|pmid-10529899|pmid-9192902|NA|pmid-17068076|pmid-10531331
The results of domain-mapping analysis manifests that SMILE binds to the LBD/AF2 domain of GR, CAR and HNF4Ξ± through the region spanning residues 113–202, which contain a LXXLL motif.
[ "25", "43", "46", "40" ]
183
38,858
0
false
The results of domain-mapping analysis manifests that SMILE binds to the LBD/AF2 domain of GR, CAR and HNF4Ξ± through the region spanning residues 113–202, which contain a LXXLL motif.
[]
The results of domain-mapping analysis manifests that SMILE binds to the LBD/AF2 domain of GR, CAR and HNF4Ξ± through the region spanning residues 113–202, which contain a LXXLL motif.
true
true
true
true
true
6,690
2
DISCUSSION
1
25
[ "B25", "B43", "B46", "B40" ]
19,429,690
pmid-11729302|pmid-10037683|pmid-15004031|pmid-10037683|pmid-15004031|pmid-17284330|pmid-8076589|pmid-10529899|pmid-10529899|pmid-12774000|pmid-10194766|pmid-10627496|pmid-12107181|pmid-10529899|pmid-9192902|NA|pmid-17068076|pmid-10531331
Surprisingly, we found that the repressive effects of SMILE on GR, CAR and HNF4Ξ± were not significantly changed by single mutation or combinatorial mutation of four LXXLL motifs (Supplementary Figure 2), indicating that LXXLL motifs are not essential for the interactions and repressive effects of SMILE in the cases of ...
[ "25", "43", "46", "40" ]
338
38,859
0
false
Surprisingly, we found that the repressive effects of SMILE on GR, CAR and HNF4Ξ± were not significantly changed by single mutation or combinatorial mutation of four LXXLL motifs (Supplementary Figure 2), indicating that LXXLL motifs are not essential for the interactions and repressive effects of SMILE in the cases of ...
[]
Surprisingly, we found that the repressive effects of SMILE on GR, CAR and HNF4Ξ± were not significantly changed by single mutation or combinatorial mutation of four LXXLL motifs, indicating that LXXLL motifs are not essential for the interactions and repressive effects of SMILE in the cases of GR, CAR and HNF4Ξ±.
true
true
true
true
true
6,690
2
DISCUSSION
1
46
[ "B25", "B43", "B46", "B40" ]
19,429,690
pmid-11729302|pmid-10037683|pmid-15004031|pmid-10037683|pmid-15004031|pmid-17284330|pmid-8076589|pmid-10529899|pmid-10529899|pmid-12774000|pmid-10194766|pmid-10627496|pmid-12107181|pmid-10529899|pmid-9192902|NA|pmid-17068076|pmid-10531331
Interestingly, this LXXLL-independent interaction was also observed between proline-rich nuclear receptor coregulatory protein (PNRC) and LBD of ERΞ± (46).
[ "25", "43", "46", "40" ]
154
38,860
1
false
Interestingly, this LXXLL-independent interaction was also observed between proline-rich nuclear receptor coregulatory protein (PNRC) and LBD of ERΞ±.
[ "46" ]
Interestingly, this LXXLL-independent interaction was also observed between proline-rich nuclear receptor coregulatory protein (PNRC) and LBD of ERΞ±.
true
true
true
true
true
6,690
2
DISCUSSION
1
40
[ "B25", "B43", "B46", "B40" ]
19,429,690
pmid-11729302|pmid-10037683|pmid-15004031|pmid-10037683|pmid-15004031|pmid-17284330|pmid-8076589|pmid-10529899|pmid-10529899|pmid-12774000|pmid-10194766|pmid-10627496|pmid-12107181|pmid-10529899|pmid-9192902|NA|pmid-17068076|pmid-10531331
In addition of using LXXLL motifs to interact with NRs, corepressor RIP140 also uses its C-terminus, which contains no LXXLL motifs, to interact with LBD of NRs (40).
[ "25", "43", "46", "40" ]
166
38,861
1
false
In addition of using LXXLL motifs to interact with NRs, corepressor RIP140 also uses its C-terminus, which contains no LXXLL motifs, to interact with LBD of NRs.
[ "40" ]
In addition of using LXXLL motifs to interact with NRs, corepressor RIP140 also uses its C-terminus, which contains no LXXLL motifs, to interact with LBD of NRs.
true
true
true
true
true
6,690
2
DISCUSSION
1
25
[ "B25", "B43", "B46", "B40" ]
19,429,690
pmid-11729302|pmid-10037683|pmid-15004031|pmid-10037683|pmid-15004031|pmid-17284330|pmid-8076589|pmid-10529899|pmid-10529899|pmid-12774000|pmid-10194766|pmid-10627496|pmid-12107181|pmid-10529899|pmid-9192902|NA|pmid-17068076|pmid-10531331
However, it remains to be determined whether the LXXLL motifs are also dispensible for the repressive effect of SMILE on other NRs, such as Nur77, LXR and FXR.
[ "25", "43", "46", "40" ]
159
38,862
0
false
However, it remains to be determined whether the LXXLL motifs are also dispensible for the repressive effect of SMILE on other NRs, such as Nur77, LXR and FXR.
[]
However, it remains to be determined whether the LXXLL motifs are also dispensible for the repressive effect of SMILE on other NRs, such as Nur77, LXR and FXR.
true
true
true
true
true
6,690
3
DISCUSSION
1
2
[ "B2", "B2" ]
19,429,690
pmid-17803935|pmid-15957004|pmid-12145209|pmid-11909518|pmid-11343897|pmid-16751179|pmid-9192902|pmid-11459854|pmid-18657049|pmid-18657049
We have recently reported that SMILE functions as a coregulator in ER signaling in association with SHP.
[ "2", "2" ]
104
38,863
0
false
We have recently reported that SMILE functions as a coregulator in ER signaling in association with SHP.
[]
We have recently reported that SMILE functions as a coregulator in ER signaling in association with SHP.
true
true
true
true
true
6,691
3
DISCUSSION
1
2
[ "B2", "B2" ]
19,429,690
pmid-17803935|pmid-15957004|pmid-12145209|pmid-11909518|pmid-11343897|pmid-16751179|pmid-9192902|pmid-11459854|pmid-18657049|pmid-18657049
The regulation of ER by SMILE depends on the existence of SHP in breast cancer MCF-7 cells (2).
[ "2", "2" ]
95
38,864
1
false
The regulation of ER by SMILE depends on the existence of SHP in breast cancer MCF-7 cells.
[ "2" ]
The regulation of ER by SMILE depends on the existence of SHP in breast cancer MCF-7 cells.
true
true
true
true
true
6,691
3
DISCUSSION
1
2
[ "B2", "B2" ]
19,429,690
pmid-17803935|pmid-15957004|pmid-12145209|pmid-11909518|pmid-11343897|pmid-16751179|pmid-9192902|pmid-11459854|pmid-18657049|pmid-18657049
In contrast, the results of our siRNA knockdown experiments indicate that SHP is not involved in the SMILE-mediated repression of GR, CAR and HNF4Ξ± (data not shown).
[ "2", "2" ]
165
38,865
0
false
In contrast, the results of our siRNA knockdown experiments indicate that SHP is not involved in the SMILE-mediated repression of GR, CAR and HNF4Ξ± (data not shown).
[]
In contrast, the results of our siRNA knockdown experiments indicate that SHP is not involved in the SMILE-mediated repression of GR, CAR and HNF4Ξ± (data not shown).
true
true
true
true
true
6,691
3
DISCUSSION
1
2
[ "B2", "B2" ]
19,429,690
pmid-17803935|pmid-15957004|pmid-12145209|pmid-11909518|pmid-11343897|pmid-16751179|pmid-9192902|pmid-11459854|pmid-18657049|pmid-18657049
In our previous study, SMILE regulates the inhibition of ER by SHP in a cell-type specific manner (2).
[ "2", "2" ]
102
38,866
1
false
In our previous study, SMILE regulates the inhibition of ER by SHP in a cell-type specific manner.
[ "2" ]
In our previous study, SMILE regulates the inhibition of ER by SHP in a cell-type specific manner.
true
true
true
true
true
6,691
3
DISCUSSION
1
2
[ "B2", "B2" ]
19,429,690
pmid-17803935|pmid-15957004|pmid-12145209|pmid-11909518|pmid-11343897|pmid-16751179|pmid-9192902|pmid-11459854|pmid-18657049|pmid-18657049
However, the repression of GR, CAR and HNF4Ξ± by SMILE is not cell-type specific, since similar repressive effects were observed in 293T, HepG2 and HeLa cells (data not shown).
[ "2", "2" ]
175
38,867
0
false
However, the repression of GR, CAR and HNF4Ξ± by SMILE is not cell-type specific, since similar repressive effects were observed in 293T, HepG2 and HeLa cells (data not shown).
[]
However, the repression of GR, CAR and HNF4Ξ± by SMILE is not cell-type specific, since similar repressive effects were observed in 293T, HepG2 and HeLa cells (data not shown).
true
true
true
true
true
6,691
4
DISCUSSION
1
31
[ "B31", "B29", "B43", "B47", "B42", "B41", "B41", "B47", "B26" ]
19,429,690
pmid-14752053|pmid-18381063|NA|pmid-12535528|pmid-15835920|pmid-15060175|pmid-15060175|pmid-12535528|pmid-11459854
Our results suggest that multiple mechanisms are involved in SMILE-mediated repression.
[ "31", "29", "43", "47", "42", "41", "41", "47", "26" ]
87
38,868
0
false
Our results suggest that multiple mechanisms are involved in SMILE-mediated repression.
[]
Our results suggest that multiple mechanisms are involved in SMILE-mediated repression.
true
true
true
true
true
6,692
4
DISCUSSION
1
31
[ "B31", "B29", "B43", "B47", "B42", "B41", "B41", "B47", "B26" ]
19,429,690
pmid-14752053|pmid-18381063|NA|pmid-12535528|pmid-15835920|pmid-15060175|pmid-15060175|pmid-12535528|pmid-11459854
One such mechanism could be competition with coactivators such as GRIP and PGC-1Ξ±, which is a common mechanism among certain NR corepressors, including SHP (31), DAX-1 (29), RIP140 (43) and the ligand-dependent corepressor (LCoR) (47).
[ "31", "29", "43", "47", "42", "41", "41", "47", "26" ]
235
38,869
1
false
One such mechanism could be competition with coactivators such as GRIP and PGC-1Ξ±, which is a common mechanism among certain NR corepressors, including SHP, DAX-1, RIP140 and the ligand-dependent corepressor (LCoR).
[ "31", "29", "43", "47" ]
One such mechanism could be competition with coactivators such as GRIP and PGC-1Ξ±, which is a common mechanism among certain NR corepressors, including SHP, DAX-1, RIP140 and the ligand-dependent corepressor (LCoR).
true
true
true
true
true
6,692
4
DISCUSSION
1
42
[ "B31", "B29", "B43", "B47", "B42", "B41", "B41", "B47", "B26" ]
19,429,690
pmid-14752053|pmid-18381063|NA|pmid-12535528|pmid-15835920|pmid-15060175|pmid-15060175|pmid-12535528|pmid-11459854
Interestingly, besides coactivator competition, SMILE has an intrinsic repressive function, like the corepressors SHP (42) and RIP140 (41).
[ "31", "29", "43", "47", "42", "41", "41", "47", "26" ]
139
38,870
1
false
Interestingly, besides coactivator competition, SMILE has an intrinsic repressive function, like the corepressors SHP and RIP140.
[ "42", "41" ]
Interestingly, besides coactivator competition, SMILE has an intrinsic repressive function, like the corepressors SHP and RIP140.
true
true
true
true
true
6,692
4
DISCUSSION
1
31
[ "B31", "B29", "B43", "B47", "B42", "B41", "B41", "B47", "B26" ]
19,429,690
pmid-14752053|pmid-18381063|NA|pmid-12535528|pmid-15835920|pmid-15060175|pmid-15060175|pmid-12535528|pmid-11459854
Moreover, we found that SMILE specifically interacts with HDAC1, HDAC3 and HDAC4.
[ "31", "29", "43", "47", "42", "41", "41", "47", "26" ]
81
38,871
0
false
Moreover, we found that SMILE specifically interacts with HDAC1, HDAC3 and HDAC4.
[]
Moreover, we found that SMILE specifically interacts with HDAC1, HDAC3 and HDAC4.
true
true
true
true
true
6,692
4
DISCUSSION
1
31
[ "B31", "B29", "B43", "B47", "B42", "B41", "B41", "B47", "B26" ]
19,429,690
pmid-14752053|pmid-18381063|NA|pmid-12535528|pmid-15835920|pmid-15060175|pmid-15060175|pmid-12535528|pmid-11459854
The inhibition of HDAC activity using the HDAC inhibitor TSA, or the knockdown of the HDACs gene expression through siRNA partially released the repression of GR and HNF4Ξ± by SMILE.
[ "31", "29", "43", "47", "42", "41", "41", "47", "26" ]
181
38,872
0
false
The inhibition of HDAC activity using the HDAC inhibitor TSA, or the knockdown of the HDACs gene expression through siRNA partially released the repression of GR and HNF4Ξ± by SMILE.
[]
The inhibition of HDAC activity using the HDAC inhibitor TSA, or the knockdown of the HDACs gene expression through siRNA partially released the repression of GR and HNF4Ξ± by SMILE.
true
true
true
true
true
6,692
4
DISCUSSION
1
31
[ "B31", "B29", "B43", "B47", "B42", "B41", "B41", "B47", "B26" ]
19,429,690
pmid-14752053|pmid-18381063|NA|pmid-12535528|pmid-15835920|pmid-15060175|pmid-15060175|pmid-12535528|pmid-11459854
In contrast, TSA showed little effect on the repression of CAR by SMILE, indicating HDAC-dependent and -independent mechanism of repression.
[ "31", "29", "43", "47", "42", "41", "41", "47", "26" ]
140
38,873
0
false
In contrast, TSA showed little effect on the repression of CAR by SMILE, indicating HDAC-dependent and -independent mechanism of repression.
[]
In contrast, TSA showed little effect on the repression of CAR by SMILE, indicating HDAC-dependent and -independent mechanism of repression.
true
true
true
true
true
6,692
4
DISCUSSION
1
31
[ "B31", "B29", "B43", "B47", "B42", "B41", "B41", "B47", "B26" ]
19,429,690
pmid-14752053|pmid-18381063|NA|pmid-12535528|pmid-15835920|pmid-15060175|pmid-15060175|pmid-12535528|pmid-11459854
Consistently, our ChIP assay results also evidenced that TSA was able to prevent SMILE-associated deacetylation of histone H3 on GR and HNF4Ξ± target gene promoters, but not on CAR target gene promoter.
[ "31", "29", "43", "47", "42", "41", "41", "47", "26" ]
201
38,874
0
false
Consistently, our ChIP assay results also evidenced that TSA was able to prevent SMILE-associated deacetylation of histone H3 on GR and HNF4Ξ± target gene promoters, but not on CAR target gene promoter.
[]
Consistently, our ChIP assay results also evidenced that TSA was able to prevent SMILE-associated deacetylation of histone H3 on GR and HNF4Ξ± target gene promoters, but not on CAR target gene promoter.
true
true
true
true
true
6,692
4
DISCUSSION
1
47
[ "B31", "B29", "B43", "B47", "B42", "B41", "B41", "B47", "B26" ]
19,429,690
pmid-14752053|pmid-18381063|NA|pmid-12535528|pmid-15835920|pmid-15060175|pmid-15060175|pmid-12535528|pmid-11459854
Of note, the TSA-sensitive and -insensitive actions of SMILE are similar to several other corepessors, including RIP140 (41) and LCoR (47).
[ "31", "29", "43", "47", "42", "41", "41", "47", "26" ]
139
38,875
1
false
Of note, the TSA-sensitive and -insensitive actions of SMILE are similar to several other corepessors, including RIP140 and LCoR.
[ "41", "47" ]
Of note, the TSA-sensitive and -insensitive actions of SMILE are similar to several other corepessors, including RIP140 and LCoR.
true
true
true
true
true
6,692
4
DISCUSSION
1
31
[ "B31", "B29", "B43", "B47", "B42", "B41", "B41", "B47", "B26" ]
19,429,690
pmid-14752053|pmid-18381063|NA|pmid-12535528|pmid-15835920|pmid-15060175|pmid-15060175|pmid-12535528|pmid-11459854
In addition, HDAC1, HDAC3 and HDAC4 are required for the repression of HNF4Ξ± by SMILE, whereas HDAC1 is not essential for the repression of GR, indicating that SMILE associations with HDACs exhibits promoter specificity.
[ "31", "29", "43", "47", "42", "41", "41", "47", "26" ]
220
38,876
0
false
In addition, HDAC1, HDAC3 and HDAC4 are required for the repression of HNF4Ξ± by SMILE, whereas HDAC1 is not essential for the repression of GR, indicating that SMILE associations with HDACs exhibits promoter specificity.
[]
In addition, HDAC1, HDAC3 and HDAC4 are required for the repression of HNF4Ξ± by SMILE, whereas HDAC1 is not essential for the repression of GR, indicating that SMILE associations with HDACs exhibits promoter specificity.
true
true
true
true
true
6,692
4
DISCUSSION
1
26
[ "B31", "B29", "B43", "B47", "B42", "B41", "B41", "B47", "B26" ]
19,429,690
pmid-14752053|pmid-18381063|NA|pmid-12535528|pmid-15835920|pmid-15060175|pmid-15060175|pmid-12535528|pmid-11459854
Similar phenomenon has been reported with the corepressors NCoR and SMRT (26).
[ "31", "29", "43", "47", "42", "41", "41", "47", "26" ]
78
38,877
1
false
Similar phenomenon has been reported with the corepressors NCoR and SMRT.
[ "26" ]
Similar phenomenon has been reported with the corepressors NCoR and SMRT.
true
true
true
true
true
6,692
5
DISCUSSION
1
48
[ "B48", "B49", "B30" ]
19,429,690
pmid-8633054|pmid-9058378|pmid-15358835
It is worth noting that the inhibition of DNA binding is one of the common repression mechanisms utilized by certain corepressors.
[ "48", "49", "30" ]
130
38,878
0
false
It is worth noting that the inhibition of DNA binding is one of the common repression mechanisms utilized by certain corepressors.
[]
It is worth noting that the inhibition of DNA binding is one of the common repression mechanisms utilized by certain corepressors.
true
true
true
true
true
6,693
5
DISCUSSION
1
30
[ "B48", "B49", "B30" ]
19,429,690
pmid-8633054|pmid-9058378|pmid-15358835
For instance, this mechanism underlies the inhibition of TR and GR by tumor suppressor p53 (48,49), and the inhibition of hepatic nuclear factor-3 (HNF3) family by the corepressor SHP (30).
[ "48", "49", "30" ]
189
38,879
1
false
For instance, this mechanism underlies the inhibition of TR and GR by tumor suppressor p53, and the inhibition of hepatic nuclear factor-3 (HNF3) family by the corepressor SHP.
[ "48,49", "30" ]
For instance, this mechanism underlies the inhibition of TR and GR by tumor suppressor p53, and the inhibition of hepatic nuclear factor-3 family by the corepressor SHP.
true
true
true
true
true
6,693
5
DISCUSSION
1
48
[ "B48", "B49", "B30" ]
19,429,690
pmid-8633054|pmid-9058378|pmid-15358835
However, our results indicate that the inhibition of DNA binding is not involved in the repression of GR, CAR, and HNF4Ξ± by SMILE, as the recruitment of SMILE exerted no detectable effect on the binding of the NRs to the promoters of IGFBP1, CYP2B6 and CYP7A1 (Figure 10A–C).
[ "48", "49", "30" ]
275
38,880
0
false
However, our results indicate that the inhibition of DNA binding is not involved in the repression of GR, CAR, and HNF4Ξ± by SMILE, as the recruitment of SMILE exerted no detectable effect on the binding of the NRs to the promoters of IGFBP1, CYP2B6 and CYP7A1 (Figure 10A–C).
[]
However, our results indicate that the inhibition of DNA binding is not involved in the repression of GR, CAR, and HNF4Ξ± by SMILE, as the recruitment of SMILE exerted no detectable effect on the binding of the NRs to the promoters of IGFBP1, CYP2B6 and CYP7A1 (Figure 10A–C).
true
true
true
true
true
6,693
5
DISCUSSION
1
48
[ "B48", "B49", "B30" ]
19,429,690
pmid-8633054|pmid-9058378|pmid-15358835
Whether this mechanism is involved in the inhibitory effect of SMILE on other NRs, including Nur77, LXR and FXR, still needs to be clarified.
[ "48", "49", "30" ]
141
38,881
0
false
Whether this mechanism is involved in the inhibitory effect of SMILE on other NRs, including Nur77, LXR and FXR, still needs to be clarified.
[]
Whether this mechanism is involved in the inhibitory effect of SMILE on other NRs, including Nur77, LXR and FXR, still needs to be clarified.
true
true
true
true
true
6,693
6
DISCUSSION
1
14
[ "B14", "B15", "B50", "B51", "B51", "B52" ]
19,429,690
pmid-17284330|pmid-12774000|pmid-18049904|pmid-17475497|pmid-17475497|pmid-11030331
GR, CAR and HNF4Ξ± are crucial for liver function, including the regulation and processing of glucose, lipids, amino acids and drug metabolism, as well as bile acid homeostasis (14,15,50).
[ "14", "15", "50", "51", "51", "52" ]
187
38,882
0
false
GR, CAR and HNF4Ξ± are crucial for liver function, including the regulation and processing of glucose, lipids, amino acids and drug metabolism, as well as bile acid homeostasis.
[ "14,15,50" ]
GR, CAR and HNF4Ξ± are crucial for liver function, including the regulation and processing of glucose, lipids, amino acids and drug metabolism, as well as bile acid homeostasis.
true
true
true
true
true
6,694
6
DISCUSSION
1
14
[ "B14", "B15", "B50", "B51", "B51", "B52" ]
19,429,690
pmid-17284330|pmid-12774000|pmid-18049904|pmid-17475497|pmid-17475497|pmid-11030331
Therefore, the repression of their transcriptional activity by SMILE indicates that SMILE may function as a negative coregulator in the aforementioned physiological processes.
[ "14", "15", "50", "51", "51", "52" ]
175
38,883
0
false
Therefore, the repression of their transcriptional activity by SMILE indicates that SMILE may function as a negative coregulator in the aforementioned physiological processes.
[]
Therefore, the repression of their transcriptional activity by SMILE indicates that SMILE may function as a negative coregulator in the aforementioned physiological processes.
true
true
true
true
true
6,694
6
DISCUSSION
1
51
[ "B14", "B15", "B50", "B51", "B51", "B52" ]
19,429,690
pmid-17284330|pmid-12774000|pmid-18049904|pmid-17475497|pmid-17475497|pmid-11030331
It has been reported that as integrators of various biological processes, several transcriptional coregulators are regulated by distinct nutritional and hormonal signals (51).
[ "14", "15", "50", "51", "51", "52" ]
175
38,884
1
false
It has been reported that as integrators of various biological processes, several transcriptional coregulators are regulated by distinct nutritional and hormonal signals.
[ "51" ]
It has been reported that as integrators of various biological processes, several transcriptional coregulators are regulated by distinct nutritional and hormonal signals.
true
true
true
true
true
6,694
6
DISCUSSION
1
51
[ "B14", "B15", "B50", "B51", "B51", "B52" ]
19,429,690
pmid-17284330|pmid-12774000|pmid-18049904|pmid-17475497|pmid-17475497|pmid-11030331
For example, activation of cAMP signaling by fasting induces the coactivator PGC-1Ξ± expression in hepatocytes, whereas the activation of insulin-signaling pathway by refeeding exhibits quite opposite effect (51).
[ "14", "15", "50", "51", "51", "52" ]
212
38,885
1
false
For example, activation of cAMP signaling by fasting induces the coactivator PGC-1Ξ± expression in hepatocytes, whereas the activation of insulin-signaling pathway by refeeding exhibits quite opposite effect.
[ "51" ]
For example, activation of cAMP signaling by fasting induces the coactivator PGC-1Ξ± expression in hepatocytes, whereas the activation of insulin-signaling pathway by refeeding exhibits quite opposite effect.
true
true
true
true
true
6,694
6
DISCUSSION
1
52
[ "B14", "B15", "B50", "B51", "B51", "B52" ]
19,429,690
pmid-17284330|pmid-12774000|pmid-18049904|pmid-17475497|pmid-17475497|pmid-11030331
Increased bile acid levels switch on the feedback pathway of bile acid synthesis through induction of the corepressor SHP (52).
[ "14", "15", "50", "51", "51", "52" ]
127
38,886
1
false
Increased bile acid levels switch on the feedback pathway of bile acid synthesis through induction of the corepressor SHP.
[ "52" ]
Increased bile acid levels switch on the feedback pathway of bile acid synthesis through induction of the corepressor SHP.
true
true
true
true
true
6,694
6
DISCUSSION
1
14
[ "B14", "B15", "B50", "B51", "B51", "B52" ]
19,429,690
pmid-17284330|pmid-12774000|pmid-18049904|pmid-17475497|pmid-17475497|pmid-11030331
Therefore, it would be necessary to study the regulation of SMILE gene expression by diverse physiological settings and intracellular signaling pathways, which is currently under investigation.
[ "14", "15", "50", "51", "51", "52" ]
193
38,887
0
false
Therefore, it would be necessary to study the regulation of SMILE gene expression by diverse physiological settings and intracellular signaling pathways, which is currently under investigation.
[]
Therefore, it would be necessary to study the regulation of SMILE gene expression by diverse physiological settings and intracellular signaling pathways, which is currently under investigation.
true
true
true
true
true
6,694
6
DISCUSSION
1
14
[ "B14", "B15", "B50", "B51", "B51", "B52" ]
19,429,690
pmid-17284330|pmid-12774000|pmid-18049904|pmid-17475497|pmid-17475497|pmid-11030331
Moreover, to better understand the function of SMILE in those aforementioned physiological processes, the SMILE knockout and transgenic animal model will be useful.
[ "14", "15", "50", "51", "51", "52" ]
164
38,888
0
false
Moreover, to better understand the function of SMILE in those aforementioned physiological processes, the SMILE knockout and transgenic animal model will be useful.
[]
Moreover, to better understand the function of SMILE in those aforementioned physiological processes, the SMILE knockout and transgenic animal model will be useful.
true
true
true
true
true
6,694
6
DISCUSSION
1
14
[ "B14", "B15", "B50", "B51", "B51", "B52" ]
19,429,690
pmid-17284330|pmid-12774000|pmid-18049904|pmid-17475497|pmid-17475497|pmid-11030331
In addition, the identification of more SMILE-interacting proteins and the elucidation of SMILE crystal structure will be helpful to illuminate the detailed mechanism of SMILE-mediated repression.
[ "14", "15", "50", "51", "51", "52" ]
196
38,889
0
false
In addition, the identification of more SMILE-interacting proteins and the elucidation of SMILE crystal structure will be helpful to illuminate the detailed mechanism of SMILE-mediated repression.
[]
In addition, the identification of more SMILE-interacting proteins and the elucidation of SMILE crystal structure will be helpful to illuminate the detailed mechanism of SMILE-mediated repression.
true
true
true
true
true
6,694
7
DISCUSSION
0
null
null
19,429,690
null
In summary, we have identified that SMILE represses GR-, CAR- and HNF4Ξ±-mediated transactivation through direct interaction.
null
124
38,890
0
false
null
null
In summary, we have identified that SMILE represses GR-, CAR- and HNF4Ξ±-mediated transactivation through direct interaction.
true
true
true
true
true
6,695
7
DISCUSSION
0
null
null
19,429,690
null
At least two mechanisms are involved in SMILE-mediated repression of the NRs, competition with coactivators, and active repression through the recruitment of HDACs.
null
164
38,891
0
false
null
null
At least two mechanisms are involved in SMILE-mediated repression of the NRs, competition with coactivators, and active repression through the recruitment of HDACs.
true
true
true
true
true
6,695
7
DISCUSSION
0
null
null
19,429,690
null
Taken together, these observations indicate that SMILE is novel corepressor and may play an important role in NR signaling.
null
123
38,892
0
false
null
null
Taken together, these observations indicate that SMILE is novel corepressor and may play an important role in NR signaling.
true
true
true
true
true
6,695
0
DISCUSSION
1
72
[ "bib72", "bib7", "bib4", "bib5", "bib6", "bib22", "bib29", "bib31", "bib31" ]
20,179,319
pmid-11111073|pmid-172501|pmid-10500120|pmid-3609608|pmid-15831488|pmid-18823126|pmid-17552909|pmid-18772377|pmid-18772377
The lipid composition of biological membranes is crucial for their functional properties, hence, the sorting of lipids in the endocytic pathway.
[ "72", "7", "4", "5", "6", "22", "29", "31", "31" ]
144
38,893
0
false
The lipid composition of biological membranes is crucial for their functional properties, hence, the sorting of lipids in the endocytic pathway.
[]
The lipid composition of biological membranes is crucial for their functional properties, hence, the sorting of lipids in the endocytic pathway.
true
true
true
true
true
6,696
0
DISCUSSION
1
72
[ "bib72", "bib7", "bib4", "bib5", "bib6", "bib22", "bib29", "bib31", "bib31" ]
20,179,319
pmid-11111073|pmid-172501|pmid-10500120|pmid-3609608|pmid-15831488|pmid-18823126|pmid-17552909|pmid-18772377|pmid-18772377
The composition of lipids in biological membranes also plays an important role during membrane degradation within endosomal/lysosomal compartments.
[ "72", "7", "4", "5", "6", "22", "29", "31", "31" ]
147
38,894
0
false
The composition of lipids in biological membranes also plays an important role during membrane degradation within endosomal/lysosomal compartments.
[]
The composition of lipids in biological membranes also plays an important role during membrane degradation within endosomal/lysosomal compartments.
true
true
true
true
true
6,696
0
DISCUSSION
1
72
[ "bib72", "bib7", "bib4", "bib5", "bib6", "bib22", "bib29", "bib31", "bib31" ]
20,179,319
pmid-11111073|pmid-172501|pmid-10500120|pmid-3609608|pmid-15831488|pmid-18823126|pmid-17552909|pmid-18772377|pmid-18772377
Cholesterol, which is a major steroid constituent of animal tissues, stabilizes plasma membranes, reduces membrane permeability, and enables the liquid-ordered phase of lipid bilayers (72).
[ "72", "7", "4", "5", "6", "22", "29", "31", "31" ]
189
38,895
1
false
Cholesterol, which is a major steroid constituent of animal tissues, stabilizes plasma membranes, reduces membrane permeability, and enables the liquid-ordered phase of lipid bilayers.
[ "72" ]
Cholesterol, which is a major steroid constituent of animal tissues, stabilizes plasma membranes, reduces membrane permeability, and enables the liquid-ordered phase of lipid bilayers.
true
true
true
true
true
6,696
0
DISCUSSION
1
7
[ "bib72", "bib7", "bib4", "bib5", "bib6", "bib22", "bib29", "bib31", "bib31" ]
20,179,319
pmid-11111073|pmid-172501|pmid-10500120|pmid-3609608|pmid-15831488|pmid-18823126|pmid-17552909|pmid-18772377|pmid-18772377
Failure of intracellular trafficking or accumulation of cholesterol in different intracellular membranes or lipoproteins could result in diseases, such as Wolman disease (7), hypercholesterolemia (4), and Niemann-Pick disease type C, a rare but fatal neurodegenerative disease (5, 6).
[ "72", "7", "4", "5", "6", "22", "29", "31", "31" ]
284
38,896
1
false
Failure of intracellular trafficking or accumulation of cholesterol in different intracellular membranes or lipoproteins could result in diseases, such as Wolman disease, hypercholesterolemia, and Niemann-Pick disease type C, a rare but fatal neurodegenerative disease.
[ "7", "4", "5, 6" ]
Failure of intracellular trafficking or accumulation of cholesterol in different intracellular membranes or lipoproteins could result in diseases, such as Wolman disease, hypercholesterolemia, and Niemann-Pick disease type C, a rare but fatal neurodegenerative disease.
true
true
true
true
true
6,696
0
DISCUSSION
1
72
[ "bib72", "bib7", "bib4", "bib5", "bib6", "bib22", "bib29", "bib31", "bib31" ]
20,179,319
pmid-11111073|pmid-172501|pmid-10500120|pmid-3609608|pmid-15831488|pmid-18823126|pmid-17552909|pmid-18772377|pmid-18772377
Sorting of cholesterol in the late endosomal compartment is important because it cannot be degraded.
[ "72", "7", "4", "5", "6", "22", "29", "31", "31" ]
100
38,897
0
false
Sorting of cholesterol in the late endosomal compartment is important because it cannot be degraded.
[]
Sorting of cholesterol in the late endosomal compartment is important because it cannot be degraded.
true
true
true
true
true
6,696
0
DISCUSSION
1
31
[ "bib72", "bib7", "bib4", "bib5", "bib6", "bib22", "bib29", "bib31", "bib31" ]
20,179,319
pmid-11111073|pmid-172501|pmid-10500120|pmid-3609608|pmid-15831488|pmid-18823126|pmid-17552909|pmid-18772377|pmid-18772377
Cholesterol has been shown to be transferred between liposomes by NPC2 (22, 29–31), and a bidirectional transfer of cholesterol between NPC1 and NPC2 has also been reported (31) (Fig.
[ "72", "7", "4", "5", "6", "22", "29", "31", "31" ]
183
38,898
1
false
Cholesterol has been shown to be transferred between liposomes by NPC2, and a bidirectional transfer of cholesterol between NPC1 and NPC2 has also been reported (Fig.
[ "22, 29–31", "31" ]
Cholesterol has been shown to be transferred between liposomes by NPC2, and a bidirectional transfer of cholesterol between NPC1 and NPC2 has also been reported (Fig.
true
true
true
true
true
6,696
0
DISCUSSION
1
72
[ "bib72", "bib7", "bib4", "bib5", "bib6", "bib22", "bib29", "bib31", "bib31" ]
20,179,319
pmid-11111073|pmid-172501|pmid-10500120|pmid-3609608|pmid-15831488|pmid-18823126|pmid-17552909|pmid-18772377|pmid-18772377
Despite this, the dual role of NPC1 and NPC2 proteins in LDL-derived cholesterol trafficking in the endosomal/lysosomal compartments still remains ambiguous.
[ "72", "7", "4", "5", "6", "22", "29", "31", "31" ]
157
38,899
0
false
Despite this, the dual role of NPC1 and NPC2 proteins in LDL-derived cholesterol trafficking in the endosomal/lysosomal compartments still remains ambiguous.
[]
Despite this, the dual role of NPC1 and NPC2 proteins in LDL-derived cholesterol trafficking in the endosomal/lysosomal compartments still remains ambiguous.
true
true
true
true
true
6,696
1
DISCUSSION
1
25
[ "bib25" ]
20,179,319
pmid-19563754
Model for lipid sorting at the stage of late endosomes (pH 5.0).
[ "25" ]
64
38,900
0
false
Model for lipid sorting at the stage of late endosomes (pH 5.0).
[]
Model for lipid sorting at the stage of late endosomes.
true
true
true
true
true
6,697
1
DISCUSSION
1
25
[ "bib25" ]
20,179,319
pmid-19563754
Acid sphingomyelinase degrades sphingomyelin to ceramide at the surface of intraendosomal vesicles.
[ "25" ]
99
38,901
0
false
Acid sphingomyelinase degrades sphingomyelin to ceramide at the surface of intraendosomal vesicles.
[]
Acid sphingomyelinase degrades sphingomyelin to ceramide at the surface of intraendosomal vesicles.
true
true
true
true
true
6,697
1
DISCUSSION
1
25
[ "bib25" ]
20,179,319
pmid-19563754
Decrease of sphingomyelin and increase of ceramide enhances the availability of cholesterol on inner membranes for NPC2 which removes cholesterol from the inner endosomal vesicles (yellow) and transfers it to the N-terminal domain of NPC1 in the limiting membrane of late endosomes (25).
[ "25" ]
287
38,902
1
false
Decrease of sphingomyelin and increase of ceramide enhances the availability of cholesterol on inner membranes for NPC2 which removes cholesterol from the inner endosomal vesicles (yellow) and transfers it to the N-terminal domain of NPC1 in the limiting membrane of late endosomes.
[ "25" ]
Decrease of sphingomyelin and increase of ceramide enhances the availability of cholesterol on inner membranes for NPC2 which removes cholesterol from the inner endosomal vesicles (yellow) and transfers it to the N-terminal domain of NPC1 in the limiting membrane of late endosomes.
true
true
true
true
true
6,697
1
DISCUSSION
1
25
[ "bib25" ]
20,179,319
pmid-19563754
NPC1 mediates cholesterol exit through the glycocalix.
[ "25" ]
54
38,903
0
false
NPC1 mediates cholesterol exit through the glycocalix.
[]
NPC1 mediates cholesterol exit through the glycocalix.
true
true
true
true
true
6,697
1
DISCUSSION
1
25
[ "bib25" ]
20,179,319
pmid-19563754
ASM, acid sphingomyelinase; NPC, Niemann-Pick type C protein, NTD, N-terminal domain.
[ "25" ]
85
38,904
0
false
ASM, acid sphingomyelinase; NPC, Niemann-Pick type C protein, NTD, N-terminal domain.
[]
ASM, acid sphingomyelinase; NPC, Niemann-Pick type C protein, NTD, N-terminal domain.
true
true
true
true
true
6,697
2
DISCUSSION
1
3
[ "bib3" ]
20,179,319
pmid-12694561
Cholesterol transfer of NPC2 under the late endosomal condition (pH 5.0) was not as high as under the lysosomal pH 4.2 (Fig.
[ "3" ]
124
38,905
0
false
Cholesterol transfer of NPC2 under the late endosomal condition (pH 5.0) was not as high as under the lysosomal pH 4.2 (Fig.
[]
Cholesterol transfer of NPC2 under the late endosomal condition (pH 5.0) was not as high as under the lysosomal pH 4.2 (Fig.
true
true
true
true
true
6,698
2
DISCUSSION
1
3
[ "bib3" ]
20,179,319
pmid-12694561
This may contribute to a higher concentration of cholesterol in the inner membranes of the late endosomal compartment than in the inner membranes of the lysosomal compartment.
[ "3" ]
175
38,906
0
false
This may contribute to a higher concentration of cholesterol in the inner membranes of the late endosomal compartment than in the inner membranes of the lysosomal compartment.
[]
This may contribute to a higher concentration of cholesterol in the inner membranes of the late endosomal compartment than in the inner membranes of the lysosomal compartment.
true
true
true
true
true
6,698
2
DISCUSSION
1
3
[ "bib3" ]
20,179,319
pmid-12694561
The difference in cholesterol content of these two compartments is most likely due to their respective physiological pH and lipid composition, especially the higher BMP concentration in the inner lysosomal membranes (3).
[ "3" ]
220
38,907
1
false
The difference in cholesterol content of these two compartments is most likely due to their respective physiological pH and lipid composition, especially the higher BMP concentration in the inner lysosomal membranes.
[ "3" ]
The difference in cholesterol content of these two compartments is most likely due to their respective physiological pH and lipid composition, especially the higher BMP concentration in the inner lysosomal membranes.
true
true
true
true
true
6,698
3
DISCUSSION
1
73
[ "bib73", "bib24", "bib74", "bib77" ]
20,179,319
NA|pmid-17573352|pmid-11292382|pmid-3922757
Ceramide, a structural component of sphingolipids and glycosphingolipids, occurs in free form as well as covalently bound to proteins in human skin (73).
[ "73", "24", "74", "77" ]
153
38,908
1
false
Ceramide, a structural component of sphingolipids and glycosphingolipids, occurs in free form as well as covalently bound to proteins in human skin.
[ "73" ]
Ceramide, a structural component of sphingolipids and glycosphingolipids, occurs in free form as well as covalently bound to proteins in human skin.
true
true
true
true
true
6,699
3
DISCUSSION
1
73
[ "bib73", "bib24", "bib74", "bib77" ]
20,179,319
NA|pmid-17573352|pmid-11292382|pmid-3922757
Therefore, ceramide transfer by lipid transfer proteins would be of physiological relevance not only for degradation but also for biosynthetic salvage processes.
[ "73", "24", "74", "77" ]
161
38,909
0
false
Therefore, ceramide transfer by lipid transfer proteins would be of physiological relevance not only for degradation but also for biosynthetic salvage processes.
[]
Therefore, ceramide transfer by lipid transfer proteins would be of physiological relevance not only for degradation but also for biosynthetic salvage processes.
true
true
true
true
true
6,699
3
DISCUSSION
1
73
[ "bib73", "bib24", "bib74", "bib77" ]
20,179,319
NA|pmid-17573352|pmid-11292382|pmid-3922757
Since Cer also acts as a cholesterol competitor, we checked whether NPC2 can transfer ceramide in addition to cholesterol.
[ "73", "24", "74", "77" ]
122
38,910
0
false
Since Cer also acts as a cholesterol competitor, we checked whether NPC2 can transfer ceramide in addition to cholesterol.
[]
Since Cer also acts as a cholesterol competitor, we checked whether NPC2 can transfer ceramide in addition to cholesterol.
true
true
true
true
true
6,699
3
DISCUSSION
1
73
[ "bib73", "bib24", "bib74", "bib77" ]
20,179,319
NA|pmid-17573352|pmid-11292382|pmid-3922757
Our data (Fig.
[ "73", "24", "74", "77" ]
14
38,911
0
false
Our data (Fig.
[]
Our data (Fig.
true
true
true
true
true
6,699
3
DISCUSSION
1
73
[ "bib73", "bib24", "bib74", "bib77" ]
20,179,319
NA|pmid-17573352|pmid-11292382|pmid-3922757
3A) demonstrate that NPC2 does not transfer ceramide, PC, PE, galactosylceramide, sulfatide, or GM1.
[ "73", "24", "74", "77" ]
100
38,912
0
false
3A) demonstrate that NPC2 does not transfer ceramide, PC, PE, galactosylceramide, sulfatide, or GM1.
[]
3A) demonstrate that NPC2 does not transfer ceramide, PC, PE, galactosylceramide, sulfatide, or GM1.
false
false
true
true
false
6,699
3
DISCUSSION
1
73
[ "bib73", "bib24", "bib74", "bib77" ]
20,179,319
NA|pmid-17573352|pmid-11292382|pmid-3922757
Its specificity for cholesterol is confirmed.
[ "73", "24", "74", "77" ]
45
38,913
0
false
Its specificity for cholesterol is confirmed.
[]
Its specificity for cholesterol is confirmed.
true
true
true
true
true
6,699
3
DISCUSSION
1
24
[ "bib73", "bib24", "bib74", "bib77" ]
20,179,319
NA|pmid-17573352|pmid-11292382|pmid-3922757
However, NPC2 is known to bind other sterols (24).
[ "73", "24", "74", "77" ]
50
38,914
1
false
However, NPC2 is known to bind other sterols.
[ "24" ]
However, NPC2 is known to bind other sterols.
true
true
true
true
true
6,699
3
DISCUSSION
1
73
[ "bib73", "bib24", "bib74", "bib77" ]
20,179,319
NA|pmid-17573352|pmid-11292382|pmid-3922757
Nevertheless, in our experiments ceramide was transferred spontaneously in the absence of NPC2, although not to the same extent as cholesterol.
[ "73", "24", "74", "77" ]
143
38,915
0
false
Nevertheless, in our experiments ceramide was transferred spontaneously in the absence of NPC2, although not to the same extent as cholesterol.
[]
Nevertheless, in our experiments ceramide was transferred spontaneously in the absence of NPC2, although not to the same extent as cholesterol.
true
true
true
true
true
6,699