paragraph_index
int64
sec
string
p_has_citation
int64
cites
string
citeids
list
pmid
int64
cited_id
string
sentences
string
all_sent_cites
list
sent_len
int64
sentence_batch_index
int64
sent_has_citation
float64
qc_fail
bool
cited_sentence
string
cites_in_sentence
list
cln_sentence
string
is_cap
bool
is_alpha
bool
ends_wp
bool
cit_qc
bool
lgtm
bool
__index_level_0__
int64
1
INTRODUCTION
1
4
[ "B4", "B5", "B6", "B7", "B8", "B9" ]
21,076,576
pmid-17581229|pmid-17611734|pmid-14567500|pmid-16401315|pmid-17785928|pmid-18607561|pmid-12615661|pmid-18607561|pmid-12615661|pmid-14662706|pmid-14698999|pmid-12379578|pmid-14698999|pmid-12560165|pmid-12695300|pmid-12379578
In general, stiffer arteries cause an early return of the pressure waves from reflectance sites and can be detected as an increase in the pulse wave velocity (PWV).
[ "4", "5", "6", "7", "8", "9" ]
164
39,616
0
false
In general, stiffer arteries cause an early return of the pressure waves from reflectance sites and can be detected as an increase in the pulse wave velocity (PWV).
[]
In general, stiffer arteries cause an early return of the pressure waves from reflectance sites and can be detected as an increase in the pulse wave velocity (PWV).
true
true
true
true
true
6,841
1
INTRODUCTION
1
6
[ "B4", "B5", "B6", "B7", "B8", "B9" ]
21,076,576
pmid-17581229|pmid-17611734|pmid-14567500|pmid-16401315|pmid-17785928|pmid-18607561|pmid-12615661|pmid-18607561|pmid-12615661|pmid-14662706|pmid-14698999|pmid-12379578|pmid-14698999|pmid-12560165|pmid-12695300|pmid-12379578
Recently a simple device to measure brachial-ankle PWV (baPWV) by recording the pulse volume at the upper arms and the ankles, has been developed [6].
[ "4", "5", "6", "7", "8", "9" ]
150
39,617
1
false
Recently a simple device to measure brachial-ankle PWV (baPWV) by recording the pulse volume at the upper arms and the ankles, has been developed.
[ "6" ]
Recently a simple device to measure brachial-ankle PWV (baPWV) by recording the pulse volume at the upper arms and the ankles, has been developed.
true
true
true
true
true
6,841
1
INTRODUCTION
1
4
[ "B4", "B5", "B6", "B7", "B8", "B9" ]
21,076,576
pmid-17581229|pmid-17611734|pmid-14567500|pmid-16401315|pmid-17785928|pmid-18607561|pmid-12615661|pmid-18607561|pmid-12615661|pmid-14662706|pmid-14698999|pmid-12379578|pmid-14698999|pmid-12560165|pmid-12695300|pmid-12379578
baPWV correlates well with carotid PWV (heart to carotid) and aortic PWV (carotid to femoral PWV)
[ "4", "5", "6", "7", "8", "9" ]
97
39,618
0
false
baPWV correlates well with carotid PWV (heart to carotid) and aortic PWV (carotid to femoral PWV)
[]
baPWV correlates well with carotid PWV (heart to carotid) and aortic PWV (carotid to femoral PWV)
false
true
false
true
false
6,841
1
INTRODUCTION
1
9
[ "B4", "B5", "B6", "B7", "B8", "B9" ]
21,076,576
pmid-17581229|pmid-17611734|pmid-14567500|pmid-16401315|pmid-17785928|pmid-18607561|pmid-12615661|pmid-18607561|pmid-12615661|pmid-14662706|pmid-14698999|pmid-12379578|pmid-14698999|pmid-12560165|pmid-12695300|pmid-12379578
[7,8], and age, smoking, lipid profiles and hypertension are the known factors to affect arterial stiffness [9].
[ "4", "5", "6", "7", "8", "9" ]
112
39,619
1
false
, and age, smoking, lipid profiles and hypertension are the known factors to affect arterial stiffness.
[ "7,8", "9" ]
, and age, smoking, lipid profiles and hypertension are the known factors to affect arterial stiffness.
false
false
true
true
false
6,841
2
INTRODUCTION
1
10
[ "B10", "B11", "B11", "B12" ]
21,076,576
pmid-10333939|pmid-12695300|pmid-12695300|pmid-12379578|pmid-18487478|pmid-15793191|pmid-19410252|pmid-19402896
A body of evidence suggests that atherosclerosis develops even from the prediabetic stage, implying the importance of early detection of subclinical atherosclerosis in much earlier period than the stage in which overt atherosclerosis develops in diabetic stage [10,11].
[ "10", "11", "11", "12" ]
269
39,620
0
false
A body of evidence suggests that atherosclerosis develops even from the prediabetic stage, implying the importance of early detection of subclinical atherosclerosis in much earlier period than the stage in which overt atherosclerosis develops in diabetic stage.
[ "10,11" ]
A body of evidence suggests that atherosclerosis develops even from the prediabetic stage, implying the importance of early detection of subclinical atherosclerosis in much earlier period than the stage in which overt atherosclerosis develops in diabetic stage.
true
true
true
true
true
6,842
2
INTRODUCTION
1
10
[ "B10", "B11", "B11", "B12" ]
21,076,576
pmid-10333939|pmid-12695300|pmid-12695300|pmid-12379578|pmid-18487478|pmid-15793191|pmid-19410252|pmid-19402896
Furthermore, there is evidence that the metabolic alteration in type 2 diabetes and impaired glucose metabolism are associated with increased arterial stiffness [11,12].
[ "10", "11", "11", "12" ]
169
39,621
0
false
Furthermore, there is evidence that the metabolic alteration in type 2 diabetes and impaired glucose metabolism are associated with increased arterial stiffness.
[ "11,12" ]
Furthermore, there is evidence that the metabolic alteration in type 2 diabetes and impaired glucose metabolism are associated with increased arterial stiffness.
true
true
true
true
true
6,842
2
INTRODUCTION
1
10
[ "B10", "B11", "B11", "B12" ]
21,076,576
pmid-10333939|pmid-12695300|pmid-12695300|pmid-12379578|pmid-18487478|pmid-15793191|pmid-19410252|pmid-19402896
We analyzed the relationship of baPWV with fasting and post-challenge plasma glucose levels in different time points during OGTT in apparently healthy Korean subjects, and also compared these metabolic parameters in subjects with different glucose tolerant status.
[ "10", "11", "11", "12" ]
264
39,622
0
false
We analyzed the relationship of baPWV with fasting and post-challenge plasma glucose levels in different time points during OGTT in apparently healthy Korean subjects, and also compared these metabolic parameters in subjects with different glucose tolerant status.
[]
We analyzed the relationship of baPWV with fasting and post-challenge plasma glucose levels in different time points during OGTT in apparently healthy Korean subjects, and also compared these metabolic parameters in subjects with different glucose tolerant status.
true
true
true
true
true
6,842
0
DISCUSSION
0
null
null
21,076,576
pmid-18487478|pmid-15793191|pmid-19410252
In this study performed in subjects without a history of type 2 diabetes, who were referred due to elevated fasting blood glucose in a health check-up program, 30-minute post-challenge glucose levels in 75 g OGTT showed the most significant association with baPWV values, reflecting acute glucose excursion after glucose...
null
396
39,623
0
false
null
null
In this study performed in subjects without a history of type 2 diabetes, who were referred due to elevated fasting blood glucose in a health check-up program, 30-minute post-challenge glucose levels in 75 g OGTT showed the most significant association with baPWV values, reflecting acute glucose excursion after glucose...
true
true
true
true
true
6,843
0
DISCUSSION
0
null
null
21,076,576
pmid-18487478|pmid-15793191|pmid-19410252
These significances were consistent even after adjustment for confounding factors, such as age, blood pressure and lipid profile, suggesting the association of 30-minute glucose could be important effector for arterial stiffness.
null
229
39,624
0
false
null
null
These significances were consistent even after adjustment for confounding factors, such as age, blood pressure and lipid profile, suggesting the association of 30-minute glucose could be important effector for arterial stiffness.
true
true
true
true
true
6,843
1
DISCUSSION
1
18
[ "B18", "B9", "B18", "B19", "B20", "B12", "B20", "B21", "B11", "B12" ]
21,076,576
pmid-17581229|pmid-17611734|pmid-14567500|pmid-16401315|pmid-17785928|pmid-18607561|pmid-12615661|pmid-18607561|pmid-12615661|pmid-14662706|pmid-14698999|pmid-12379578|pmid-14698999|pmid-12560165|pmid-12695300|pmid-12379578
Cardiovascular disease is one of the important causes for mortality in patients with diabetes mellitus, and the measurement method for the vascular complication is very important.
[ "18", "9", "18", "19", "20", "12", "20", "21", "11", "12" ]
179
39,625
0
false
Cardiovascular disease is one of the important causes for mortality in patients with diabetes mellitus, and the measurement method for the vascular complication is very important.
[]
Cardiovascular disease is one of the important causes for mortality in patients with diabetes mellitus, and the measurement method for the vascular complication is very important.
true
true
true
true
true
6,844
1
DISCUSSION
1
18
[ "B18", "B9", "B18", "B19", "B20", "B12", "B20", "B21", "B11", "B12" ]
21,076,576
pmid-17581229|pmid-17611734|pmid-14567500|pmid-16401315|pmid-17785928|pmid-18607561|pmid-12615661|pmid-18607561|pmid-12615661|pmid-14662706|pmid-14698999|pmid-12379578|pmid-14698999|pmid-12560165|pmid-12695300|pmid-12379578
The importance for the assessment of arterial stiffness lies in its predictability for subclinical atherosclerosis and the prevention of future cardiovascular events [18].
[ "18", "9", "18", "19", "20", "12", "20", "21", "11", "12" ]
171
39,626
1
false
The importance for the assessment of arterial stiffness lies in its predictability for subclinical atherosclerosis and the prevention of future cardiovascular events.
[ "18" ]
The importance for the assessment of arterial stiffness lies in its predictability for subclinical atherosclerosis and the prevention of future cardiovascular events.
true
true
true
true
true
6,844
1
DISCUSSION
1
18
[ "B18", "B9", "B18", "B19", "B20", "B12", "B20", "B21", "B11", "B12" ]
21,076,576
pmid-17581229|pmid-17611734|pmid-14567500|pmid-16401315|pmid-17785928|pmid-18607561|pmid-12615661|pmid-18607561|pmid-12615661|pmid-14662706|pmid-14698999|pmid-12379578|pmid-14698999|pmid-12560165|pmid-12695300|pmid-12379578
Arterial stiffness could be measured in many ways, including distensibility, pulse wave velocity and augmentation index.
[ "18", "9", "18", "19", "20", "12", "20", "21", "11", "12" ]
120
39,627
0
false
Arterial stiffness could be measured in many ways, including distensibility, pulse wave velocity and augmentation index.
[]
Arterial stiffness could be measured in many ways, including distensibility, pulse wave velocity and augmentation index.
true
true
true
true
true
6,844
1
DISCUSSION
1
9
[ "B18", "B9", "B18", "B19", "B20", "B12", "B20", "B21", "B11", "B12" ]
21,076,576
pmid-17581229|pmid-17611734|pmid-14567500|pmid-16401315|pmid-17785928|pmid-18607561|pmid-12615661|pmid-18607561|pmid-12615661|pmid-14662706|pmid-14698999|pmid-12379578|pmid-14698999|pmid-12560165|pmid-12695300|pmid-12379578
The arterial PWV, especially of the aorta, has emerged as an important independent predictor of cardiovascular events, and it is reflected with the speed with which the arterial pressure wave progresses through the arterial tree, and this increases with increasing vascular stiffness [9].
[ "18", "9", "18", "19", "20", "12", "20", "21", "11", "12" ]
288
39,628
1
false
The arterial PWV, especially of the aorta, has emerged as an important independent predictor of cardiovascular events, and it is reflected with the speed with which the arterial pressure wave progresses through the arterial tree, and this increases with increasing vascular stiffness.
[ "9" ]
The arterial PWV, especially of the aorta, has emerged as an important independent predictor of cardiovascular events, and it is reflected with the speed with which the arterial pressure wave progresses through the arterial tree, and this increases with increasing vascular stiffness.
true
true
true
true
true
6,844
1
DISCUSSION
1
18
[ "B18", "B9", "B18", "B19", "B20", "B12", "B20", "B21", "B11", "B12" ]
21,076,576
pmid-17581229|pmid-17611734|pmid-14567500|pmid-16401315|pmid-17785928|pmid-18607561|pmid-12615661|pmid-18607561|pmid-12615661|pmid-14662706|pmid-14698999|pmid-12379578|pmid-14698999|pmid-12560165|pmid-12695300|pmid-12379578
Increased PWV occurs with a range of estabilished cardiovascular risk factors, including age, hypercholesterolemia, smoking, and sedentary life style [18,19].
[ "18", "9", "18", "19", "20", "12", "20", "21", "11", "12" ]
158
39,629
0
false
Increased PWV occurs with a range of estabilished cardiovascular risk factors, including age, hypercholesterolemia, smoking, and sedentary life style.
[ "18,19" ]
Increased PWV occurs with a range of estabilished cardiovascular risk factors, including age, hypercholesterolemia, smoking, and sedentary life style.
true
true
true
true
true
6,844
1
DISCUSSION
1
20
[ "B18", "B9", "B18", "B19", "B20", "B12", "B20", "B21", "B11", "B12" ]
21,076,576
pmid-17581229|pmid-17611734|pmid-14567500|pmid-16401315|pmid-17785928|pmid-18607561|pmid-12615661|pmid-18607561|pmid-12615661|pmid-14662706|pmid-14698999|pmid-12379578|pmid-14698999|pmid-12560165|pmid-12695300|pmid-12379578
Diabetic patients have increased arterial stiffness, and compromised PWV have been demonstrated even before the onset of diabetes, in patients with impaired glucose tolerance [20].
[ "18", "9", "18", "19", "20", "12", "20", "21", "11", "12" ]
180
39,630
1
false
Diabetic patients have increased arterial stiffness, and compromised PWV have been demonstrated even before the onset of diabetes, in patients with impaired glucose tolerance.
[ "20" ]
Diabetic patients have increased arterial stiffness, and compromised PWV have been demonstrated even before the onset of diabetes, in patients with impaired glucose tolerance.
true
true
true
true
true
6,844
1
DISCUSSION
1
18
[ "B18", "B9", "B18", "B19", "B20", "B12", "B20", "B21", "B11", "B12" ]
21,076,576
pmid-17581229|pmid-17611734|pmid-14567500|pmid-16401315|pmid-17785928|pmid-18607561|pmid-12615661|pmid-18607561|pmid-12615661|pmid-14662706|pmid-14698999|pmid-12379578|pmid-14698999|pmid-12560165|pmid-12695300|pmid-12379578
Healthy offspring of type 2 diabetes patients have a higher PWV than matched controls [12,20].
[ "18", "9", "18", "19", "20", "12", "20", "21", "11", "12" ]
94
39,631
0
false
Healthy offspring of type 2 diabetes patients have a higher PWV than matched controls.
[ "12,20" ]
Healthy offspring of type 2 diabetes patients have a higher PWV than matched controls.
true
true
true
true
true
6,844
1
DISCUSSION
1
21
[ "B18", "B9", "B18", "B19", "B20", "B12", "B20", "B21", "B11", "B12" ]
21,076,576
pmid-17581229|pmid-17611734|pmid-14567500|pmid-16401315|pmid-17785928|pmid-18607561|pmid-12615661|pmid-18607561|pmid-12615661|pmid-14662706|pmid-14698999|pmid-12379578|pmid-14698999|pmid-12560165|pmid-12695300|pmid-12379578
Arterial stiffness in diabetes is related to prevalent CVA, and has shown to be an independent predictor of coronary heart disease [21].
[ "18", "9", "18", "19", "20", "12", "20", "21", "11", "12" ]
136
39,632
1
false
Arterial stiffness in diabetes is related to prevalent CVA, and has shown to be an independent predictor of coronary heart disease.
[ "21" ]
Arterial stiffness in diabetes is related to prevalent CVA, and has shown to be an independent predictor of coronary heart disease.
true
true
true
true
true
6,844
1
DISCUSSION
1
11
[ "B18", "B9", "B18", "B19", "B20", "B12", "B20", "B21", "B11", "B12" ]
21,076,576
pmid-17581229|pmid-17611734|pmid-14567500|pmid-16401315|pmid-17785928|pmid-18607561|pmid-12615661|pmid-18607561|pmid-12615661|pmid-14662706|pmid-14698999|pmid-12379578|pmid-14698999|pmid-12560165|pmid-12695300|pmid-12379578
In the Hoorn study, baseline distensibility did not predict mortality in subjects with impaired glucose tolerance during a follow-up period of 6.6 years [11].
[ "18", "9", "18", "19", "20", "12", "20", "21", "11", "12" ]
158
39,633
1
false
In the Hoorn study, baseline distensibility did not predict mortality in subjects with impaired glucose tolerance during a follow-up period of 6.6 years.
[ "11" ]
In the Hoorn study, baseline distensibility did not predict mortality in subjects with impaired glucose tolerance during a follow-up period of 6.6 years.
true
true
true
true
true
6,844
1
DISCUSSION
1
12
[ "B18", "B9", "B18", "B19", "B20", "B12", "B20", "B21", "B11", "B12" ]
21,076,576
pmid-17581229|pmid-17611734|pmid-14567500|pmid-16401315|pmid-17785928|pmid-18607561|pmid-12615661|pmid-18607561|pmid-12615661|pmid-14662706|pmid-14698999|pmid-12379578|pmid-14698999|pmid-12560165|pmid-12695300|pmid-12379578
In contrast, PWV seemed to have reasonable predictable value for mortality in patients with impaired glucose tolerance and type 2 diabetes mellitus [12].
[ "18", "9", "18", "19", "20", "12", "20", "21", "11", "12" ]
153
39,634
1
false
In contrast, PWV seemed to have reasonable predictable value for mortality in patients with impaired glucose tolerance and type 2 diabetes mellitus.
[ "12" ]
In contrast, PWV seemed to have reasonable predictable value for mortality in patients with impaired glucose tolerance and type 2 diabetes mellitus.
true
true
true
true
true
6,844
2
DISCUSSION
1
1
[ "B1", "B2", "B3", "B22" ]
21,076,576
pmid-10333939|pmid-12695300|pmid-12695300|pmid-12379578|pmid-18487478|pmid-15793191|pmid-19410252|pmid-19402896
The importance of post-challenge glucose levels during OGTT other than 2-hour glucose levels, such as 30-minute or 1-hour glucose level, in glucose metabolism has not been clearly defined.
[ "1", "2", "3", "22" ]
188
39,635
0
false
The importance of post-challenge glucose levels during OGTT other than 2-hour glucose levels, such as 30-minute or 1-hour glucose level, in glucose metabolism has not been clearly defined.
[]
The importance of post-challenge glucose levels during OGTT other than 2-hour glucose levels, such as 30-minute or 1-hour glucose level, in glucose metabolism has not been clearly defined.
true
true
true
true
true
6,845
2
DISCUSSION
1
1
[ "B1", "B2", "B3", "B22" ]
21,076,576
pmid-10333939|pmid-12695300|pmid-12695300|pmid-12379578|pmid-18487478|pmid-15793191|pmid-19410252|pmid-19402896
Although glucose tolerance status is defined mainly by fasting and post-challenge 2-hour glucose levels, a few studies have suggested that a certain cutoff value of 1-hour glucose during OGTT can stratify subjects with normal glucose tolerance (NGT) into categories of low or high risk for development of type 2 diabetes...
[ "1", "2", "3", "22" ]
327
39,636
0
false
Although glucose tolerance status is defined mainly by fasting and post-challenge 2-hour glucose levels, a few studies have suggested that a certain cutoff value of 1-hour glucose during OGTT can stratify subjects with normal glucose tolerance (NGT) into categories of low or high risk for development of type 2 diabetes...
[ "1,2" ]
Although glucose tolerance status is defined mainly by fasting and post-challenge 2-hour glucose levels, a few studies have suggested that a certain cutoff value of 1-hour glucose during OGTT can stratify subjects with normal glucose tolerance (NGT) into categories of low or high risk for development of type 2 diabetes...
true
true
true
true
true
6,845
2
DISCUSSION
1
1
[ "B1", "B2", "B3", "B22" ]
21,076,576
pmid-10333939|pmid-12695300|pmid-12695300|pmid-12379578|pmid-18487478|pmid-15793191|pmid-19410252|pmid-19402896
In a recent study by Succurro et al.
[ "1", "2", "3", "22" ]
36
39,637
0
false
In a recent study by Succurro et al.
[]
In a recent study by Succurro et al.
true
true
true
true
true
6,845
2
DISCUSSION
1
3
[ "B1", "B2", "B3", "B22" ]
21,076,576
pmid-10333939|pmid-12695300|pmid-12695300|pmid-12379578|pmid-18487478|pmid-15793191|pmid-19410252|pmid-19402896
[3], NGT subjects with a 1-hour post-load glucose ≥ 155 mg/dL have an atherogenic profile including intima-media thickness similar to IGT subjects, suggesting the association of post-challenge glucose levels other than 2-hour glucose level with development of atherosclerosis and diabetes mellitus.
[ "1", "2", "3", "22" ]
298
39,638
1
false
, NGT subjects with a 1-hour post-load glucose ≥ 155 mg/dL have an atherogenic profile including intima-media thickness similar to IGT subjects, suggesting the association of post-challenge glucose levels other than 2-hour glucose level with development of atherosclerosis and diabetes mellitus.
[ "3" ]
, NGT subjects with a 1-hour post-load glucose ≥ 155 mg/dL have an atherogenic profile including intima-media thickness similar to IGT subjects, suggesting the association of post-challenge glucose levels other than 2-hour glucose level with development of atherosclerosis and diabetes mellitus.
false
false
true
true
false
6,845
2
DISCUSSION
1
22
[ "B1", "B2", "B3", "B22" ]
21,076,576
pmid-10333939|pmid-12695300|pmid-12695300|pmid-12379578|pmid-18487478|pmid-15793191|pmid-19410252|pmid-19402896
Although the role of other post-challenge glucose levels other than 2-hour glucose levels during OGTT in the relationship with development of diabetes or atherosclerosis is not clearly defined, it is evident that acute hyperglycemia in response to oral glucose load suppresses endothelium-dependent vasodilation, increas...
[ "1", "2", "3", "22" ]
447
39,639
1
false
Although the role of other post-challenge glucose levels other than 2-hour glucose levels during OGTT in the relationship with development of diabetes or atherosclerosis is not clearly defined, it is evident that acute hyperglycemia in response to oral glucose load suppresses endothelium-dependent vasodilation, increas...
[ "22" ]
Although the role of other post-challenge glucose levels other than 2-hour glucose levels during OGTT in the relationship with development of diabetes or atherosclerosis is not clearly defined, it is evident that acute hyperglycemia in response to oral glucose load suppresses endothelium-dependent vasodilation, increas...
true
true
true
true
true
6,845
3
DISCUSSION
1
23
[ "B23", "B24", "B7", "B5" ]
21,076,576
pmid-15308473|pmid-11176766|pmid-16401315|pmid-17611734
In our study, post-challenge 30-minute glucose level showed significant correlation with baPWV values and this significance was significant even after adjustment for cardiovascular risk factors.
[ "23", "24", "7", "5" ]
194
39,640
0
false
In our study, post-challenge 30-minute glucose level showed significant correlation with baPWV values and this significance was significant even after adjustment for cardiovascular risk factors.
[]
In our study, post-challenge 30-minute glucose level showed significant correlation with baPWV values and this significance was significant even after adjustment for cardiovascular risk factors.
true
true
true
true
true
6,846
3
DISCUSSION
1
23
[ "B23", "B24", "B7", "B5" ]
21,076,576
pmid-15308473|pmid-11176766|pmid-16401315|pmid-17611734
This significance was stronger than those with fasting or 2-hour post-load glucose levels, implying the association of acute hyperglycemia after oral glucose loading with arterial stiffness.
[ "23", "24", "7", "5" ]
190
39,641
0
false
This significance was stronger than those with fasting or 2-hour post-load glucose levels, implying the association of acute hyperglycemia after oral glucose loading with arterial stiffness.
[]
This significance was stronger than those with fasting or 2-hour post-load glucose levels, implying the association of acute hyperglycemia after oral glucose loading with arterial stiffness.
true
true
true
true
true
6,846
3
DISCUSSION
1
23
[ "B23", "B24", "B7", "B5" ]
21,076,576
pmid-15308473|pmid-11176766|pmid-16401315|pmid-17611734
Large epidemiological studies, such as the Diabetes Epidemiology: Collaborative analysis Of Diagnostic criteria in Europe (DECODE) Study, have shown a stronger association of post-challenge glycemia with cardiovascular outcomes compared with fasting glucose level and higher glucose levels after glucose challenge [23,24...
[ "23", "24", "7", "5" ]
322
39,642
0
false
Large epidemiological studies, such as the Diabetes Epidemiology: Collaborative analysis Of Diagnostic criteria in Europe (DECODE) Study, have shown a stronger association of post-challenge glycemia with cardiovascular outcomes compared with fasting glucose level and higher glucose levels after glucose challenge.
[ "23,24" ]
Large epidemiological studies, such as the Diabetes Epidemiology: Collaborative analysis Of Diagnostic criteria in Europe (DECODE) Study, have shown a stronger association of post-challenge glycemia with cardiovascular outcomes compared with fasting glucose level and higher glucose levels after glucose challenge.
true
true
true
true
true
6,846
3
DISCUSSION
1
23
[ "B23", "B24", "B7", "B5" ]
21,076,576
pmid-15308473|pmid-11176766|pmid-16401315|pmid-17611734
In the study by Kasayama et al.
[ "23", "24", "7", "5" ]
31
39,643
0
false
In the study by Kasayama et al.
[]
In the study by Kasayama et al.
true
true
true
true
true
6,846
3
DISCUSSION
1
7
[ "B23", "B24", "B7", "B5" ]
21,076,576
pmid-15308473|pmid-11176766|pmid-16401315|pmid-17611734
[7], 2-hour post-load glucose level in OGTT showed weak but significant correlation with PWV levels in male subjects.
[ "23", "24", "7", "5" ]
117
39,644
1
false
, 2-hour post-load glucose level in OGTT showed weak but significant correlation with PWV levels in male subjects.
[ "7" ]
, 2-hour post-load glucose level in OGTT showed weak but significant correlation with PWV levels in male subjects.
false
false
true
true
false
6,846
3
DISCUSSION
1
5
[ "B23", "B24", "B7", "B5" ]
21,076,576
pmid-15308473|pmid-11176766|pmid-16401315|pmid-17611734
In another study performed in type 1 diabetes patients, acute hyperglycemia during hyperglycemic clamp test showed significant correlation with increased baPWV, emphasizing the importance of post-load glucose control in the development of atherosclerosis [5].
[ "23", "24", "7", "5" ]
259
39,645
1
false
In another study performed in type 1 diabetes patients, acute hyperglycemia during hyperglycemic clamp test showed significant correlation with increased baPWV, emphasizing the importance of post-load glucose control in the development of atherosclerosis.
[ "5" ]
In another study performed in type 1 diabetes patients, acute hyperglycemia during hyperglycemic clamp test showed significant correlation with increased baPWV, emphasizing the importance of post-load glucose control in the development of atherosclerosis.
true
true
true
true
true
6,846
3
DISCUSSION
1
23
[ "B23", "B24", "B7", "B5" ]
21,076,576
pmid-15308473|pmid-11176766|pmid-16401315|pmid-17611734
These results from the previous studies are similar with our study result in that post-load hyperglycemia is deleterious for the vessel, but differ from our study in that our study showed the association of rapidly increased post-load glucose earlier than 2 hours with arterial stiffness.
[ "23", "24", "7", "5" ]
288
39,646
0
false
These results from the previous studies are similar with our study result in that post-load hyperglycemia is deleterious for the vessel, but differ from our study in that our study showed the association of rapidly increased post-load glucose earlier than 2 hours with arterial stiffness.
[]
These results from the previous studies are similar with our study result in that post-load hyperglycemia is deleterious for the vessel, but differ from our study in that our study showed the association of rapidly increased post-load glucose earlier than 2 hours with arterial stiffness.
true
true
true
true
true
6,846
3
DISCUSSION
1
23
[ "B23", "B24", "B7", "B5" ]
21,076,576
pmid-15308473|pmid-11176766|pmid-16401315|pmid-17611734
Further well-designed studies are warranted to define the significant role of 30-minute or 1-hour post-load glucose levels in the prediction of type 2 diabetes in NGT subjects and in the development of atherosclerosis.
[ "23", "24", "7", "5" ]
218
39,647
0
false
Further well-designed studies are warranted to define the significant role of 30-minute or 1-hour post-load glucose levels in the prediction of type 2 diabetes in NGT subjects and in the development of atherosclerosis.
[]
Further well-designed studies are warranted to define the significant role of 30-minute or 1-hour post-load glucose levels in the prediction of type 2 diabetes in NGT subjects and in the development of atherosclerosis.
true
true
true
true
true
6,846
4
DISCUSSION
0
null
null
21,076,576
null
Our study has limitations.
null
26
39,648
0
false
null
null
Our study has limitations.
true
true
true
true
true
6,847
4
DISCUSSION
0
null
null
21,076,576
null
As these study subjects were referred to Endocrinology Department due to the detection of at least one time of high fasting glucose level, all of the study subjects could be categorized as having impaired fasting glucose.
null
221
39,649
0
false
null
null
As these study subjects were referred to Endocrinology Department due to the detection of at least one time of high fasting glucose level, all of the study subjects could be categorized as having impaired fasting glucose.
true
true
true
true
true
6,847
4
DISCUSSION
0
null
null
21,076,576
null
This could be the reason for the absence of difference in mean baPWV between subjects with normoglycemia and prediabetes.
null
121
39,650
0
false
null
null
This could be the reason for the absence of difference in mean baPWV between subjects with normoglycemia and prediabetes.
true
true
true
true
true
6,847
4
DISCUSSION
0
null
null
21,076,576
null
However, significantly increased baPWV in diabetes subjects compared with prediabetes subjects show the significantly affected arterial stiffness according to glucose tolerant status.
null
183
39,651
0
false
null
null
However, significantly increased baPWV in diabetes subjects compared with prediabetes subjects show the significantly affected arterial stiffness according to glucose tolerant status.
true
true
true
true
true
6,847
5
DISCUSSION
0
null
null
21,076,576
null
In conclusion, our data suggests the association of post-challenge 30-minute glucose level during OGTT other than 120-minute or fasting glucose levels with arterial stiffness in Korean subjects in whom 75 g OGTT was performed due to fasting hyperglycemia.
null
255
39,652
0
false
null
null
In conclusion, our data suggests the association of post-challenge 30-minute glucose level during OGTT other than 120-minute or fasting glucose levels with arterial stiffness in Korean subjects in whom 75 g OGTT was performed due to fasting hyperglycemia.
true
true
true
true
true
6,848
5
DISCUSSION
0
null
null
21,076,576
null
This result warrants the further researches to clarify the significance of acute glucose excursions in the development of atherosclerosis.
null
138
39,653
0
false
null
null
This result warrants the further researches to clarify the significance of acute glucose excursions in the development of atherosclerosis.
true
true
true
true
true
6,848
0
INTRODUCTION
1
1
[ "B1", "B4", "B2", "B1", "B5", "B6" ]
21,165,201
pmid-17698126|pmid-19296977|pmid-9334635|pmid-17698126|pmid-11956420|pmid-15540749|pmid-17993340
The optimal treatment modality for proximal ureteral stones of various sizes has not yet been defined.
[ "1", "4", "2", "1", "5", "6" ]
102
39,654
0
false
The optimal treatment modality for proximal ureteral stones of various sizes has not yet been defined.
[]
The optimal treatment modality for proximal ureteral stones of various sizes has not yet been defined.
true
true
true
true
true
6,849
0
INTRODUCTION
1
1
[ "B1", "B4", "B2", "B1", "B5", "B6" ]
21,165,201
pmid-17698126|pmid-19296977|pmid-9334635|pmid-17698126|pmid-11956420|pmid-15540749|pmid-17993340
The treatment decision for proximal ureteral stones is made depending on stone factors as well as technical and clinical factors such as availability of treatment modality, patient preference, and doctor's attributes [1-4].
[ "1", "4", "2", "1", "5", "6" ]
223
39,655
0
false
The treatment decision for proximal ureteral stones is made depending on stone factors as well as technical and clinical factors such as availability of treatment modality, patient preference, and doctor's attributes.
[ "1-4" ]
The treatment decision for proximal ureteral stones is made depending on stone factors as well as technical and clinical factors such as availability of treatment modality, patient preference, and doctor's attributes.
true
true
true
true
true
6,849
0
INTRODUCTION
1
1
[ "B1", "B4", "B2", "B1", "B5", "B6" ]
21,165,201
pmid-17698126|pmid-19296977|pmid-9334635|pmid-17698126|pmid-11956420|pmid-15540749|pmid-17993340
Shock wave lithotripsy (SWL) and ureteroscopic removal of stone (URS) are positioned as the initial treatment options for proximal ureteral stones with a low probability of spontaneous passage.
[ "1", "4", "2", "1", "5", "6" ]
193
39,656
0
false
Shock wave lithotripsy (SWL) and ureteroscopic removal of stone (URS) are positioned as the initial treatment options for proximal ureteral stones with a low probability of spontaneous passage.
[]
Shock wave lithotripsy (SWL) and ureteroscopic removal of stone (URS) are positioned as the initial treatment options for proximal ureteral stones with a low probability of spontaneous passage.
true
true
true
true
true
6,849
0
INTRODUCTION
1
2
[ "B1", "B4", "B2", "B1", "B5", "B6" ]
21,165,201
pmid-17698126|pmid-19296977|pmid-9334635|pmid-17698126|pmid-11956420|pmid-15540749|pmid-17993340
Whereas SWL has been used as the first-line treatment in patients with <10 mm proximal ureteral stones, owing to its lower rate of complications and noninvasiveness [2], it has the disadvantage of a higher retreatment rate and longer period until stone clearance.
[ "1", "4", "2", "1", "5", "6" ]
263
39,657
1
false
Whereas SWL has been used as the first-line treatment in patients with <10 mm proximal ureteral stones, owing to its lower rate of complications and noninvasiveness, it has the disadvantage of a higher retreatment rate and longer period until stone clearance.
[ "2" ]
Whereas SWL has been used as the first-line treatment in patients with <10 mm proximal ureteral stones, owing to its lower rate of complications and noninvasiveness, it has the disadvantage of a higher retreatment rate and longer period until stone clearance.
true
true
true
true
true
6,849
0
INTRODUCTION
1
1
[ "B1", "B4", "B2", "B1", "B5", "B6" ]
21,165,201
pmid-17698126|pmid-19296977|pmid-9334635|pmid-17698126|pmid-11956420|pmid-15540749|pmid-17993340
With technical advances in endoscopy and lithotripters, URS has been reported to have a better chance of stone clearance with a single procedure even for proximal ureteral stones >10 mm
[ "1", "4", "2", "1", "5", "6" ]
185
39,658
0
false
With technical advances in endoscopy and lithotripters, URS has been reported to have a better chance of stone clearance with a single procedure even for proximal ureteral stones >10 mm
[]
With technical advances in endoscopy and lithotripters, URS has been reported to have a better chance of stone clearance with a single procedure even for proximal ureteral stones >10 mm
true
true
false
true
false
6,849
0
INTRODUCTION
1
1
[ "B1", "B4", "B2", "B1", "B5", "B6" ]
21,165,201
pmid-17698126|pmid-19296977|pmid-9334635|pmid-17698126|pmid-11956420|pmid-15540749|pmid-17993340
However, URS requires regional or general anesthesia and has relatively higher complication rates than does SWL.
[ "1", "4", "2", "1", "5", "6" ]
112
39,659
0
false
However, URS requires regional or general anesthesia and has relatively higher complication rates than does SWL.
[]
However, URS requires regional or general anesthesia and has relatively higher complication rates than does SWL.
true
true
true
true
true
6,849
1
INTRODUCTION
1
1
[ "B1", "B5", "B9" ]
21,165,201
pmid-17698126|pmid-11956420|NA|pmid-11956420|pmid-15893812|pmid-9895251|pmid-11956420|pmid-15893812|pmid-9895251|pmid-14499685|pmid-11956420|pmid-15893812|pmid-11061877|pmid-14499685
In order to make recommendations on the optimal treatment choice for proximal ureteral stones, many studies to date have analyzed the outcomes of the two treatment modalities from an objective viewpoint such as stone-free rates and complications [1,5-9].
[ "1", "5", "9" ]
254
39,660
0
false
In order to make recommendations on the optimal treatment choice for proximal ureteral stones, many studies to date have analyzed the outcomes of the two treatment modalities from an objective viewpoint such as stone-free rates and complications.
[ "1,5-9" ]
In order to make recommendations on the optimal treatment choice for proximal ureteral stones, many studies to date have analyzed the outcomes of the two treatment modalities from an objective viewpoint such as stone-free rates and complications.
true
true
true
true
true
6,850
1
INTRODUCTION
1
1
[ "B1", "B5", "B9" ]
21,165,201
pmid-17698126|pmid-11956420|NA|pmid-11956420|pmid-15893812|pmid-9895251|pmid-11956420|pmid-15893812|pmid-9895251|pmid-14499685|pmid-11956420|pmid-15893812|pmid-11061877|pmid-14499685
However, few studies have analyzed the subjective satisfaction of the patients in the treatment of proximal ureteral stones.
[ "1", "5", "9" ]
124
39,661
0
false
However, few studies have analyzed the subjective satisfaction of the patients in the treatment of proximal ureteral stones.
[]
However, few studies have analyzed the subjective satisfaction of the patients in the treatment of proximal ureteral stones.
true
true
true
true
true
6,850
1
INTRODUCTION
1
1
[ "B1", "B5", "B9" ]
21,165,201
pmid-17698126|pmid-11956420|NA|pmid-11956420|pmid-15893812|pmid-9895251|pmid-11956420|pmid-15893812|pmid-9895251|pmid-14499685|pmid-11956420|pmid-15893812|pmid-11061877|pmid-14499685
Subjective satisfaction of the patients should be considered as an important factor because it reflects how much of the patients' expectations were met by the specific treatment.
[ "1", "5", "9" ]
178
39,662
0
false
Subjective satisfaction of the patients should be considered as an important factor because it reflects how much of the patients' expectations were met by the specific treatment.
[]
Subjective satisfaction of the patients should be considered as an important factor because it reflects how much of the patients' expectations were met by the specific treatment.
true
true
true
true
true
6,850
1
INTRODUCTION
1
1
[ "B1", "B5", "B9" ]
21,165,201
pmid-17698126|pmid-11956420|NA|pmid-11956420|pmid-15893812|pmid-9895251|pmid-11956420|pmid-15893812|pmid-9895251|pmid-14499685|pmid-11956420|pmid-15893812|pmid-11061877|pmid-14499685
In the present study, we examined patient satisfaction with treatment outcomes in patients who were treated with SWL or URS for proximal ureteral stones.
[ "1", "5", "9" ]
153
39,663
0
false
In the present study, we examined patient satisfaction with treatment outcomes in patients who were treated with SWL or URS for proximal ureteral stones.
[]
In the present study, we examined patient satisfaction with treatment outcomes in patients who were treated with SWL or URS for proximal ureteral stones.
true
true
true
true
true
6,850
0
DISCUSSION
1
3
[ "B3" ]
21,165,201
pmid-17698126|pmid-19296977|pmid-9334635|pmid-17698126|pmid-11956420|pmid-15540749|pmid-17993340
Both SWL and URS are acceptable first-line treatments for ureteral stones including proximal ureteral stones [3].
[ "3" ]
113
39,664
1
false
Both SWL and URS are acceptable first-line treatments for ureteral stones including proximal ureteral stones.
[ "3" ]
Both SWL and URS are acceptable first-line treatments for ureteral stones including proximal ureteral stones.
true
true
true
true
true
6,851
0
DISCUSSION
1
3
[ "B3" ]
21,165,201
pmid-17698126|pmid-19296977|pmid-9334635|pmid-17698126|pmid-11956420|pmid-15540749|pmid-17993340
Besides objective outcomes such as stone-free rates and complications, patient perception of the specific treatment modality is another important consideration in determining the treatment method for proximal ureteral stones.
[ "3" ]
225
39,665
0
false
Besides objective outcomes such as stone-free rates and complications, patient perception of the specific treatment modality is another important consideration in determining the treatment method for proximal ureteral stones.
[]
Besides objective outcomes such as stone-free rates and complications, patient perception of the specific treatment modality is another important consideration in determining the treatment method for proximal ureteral stones.
true
true
true
true
true
6,851
0
DISCUSSION
1
3
[ "B3" ]
21,165,201
pmid-17698126|pmid-19296977|pmid-9334635|pmid-17698126|pmid-11956420|pmid-15540749|pmid-17993340
However, patient perception has not been assessed as much as objective outcomes.
[ "3" ]
80
39,666
0
false
However, patient perception has not been assessed as much as objective outcomes.
[]
However, patient perception has not been assessed as much as objective outcomes.
true
true
true
true
true
6,851
0
DISCUSSION
1
3
[ "B3" ]
21,165,201
pmid-17698126|pmid-19296977|pmid-9334635|pmid-17698126|pmid-11956420|pmid-15540749|pmid-17993340
In the current study, we examined subjective patient satisfaction with objective outcomes in patients undergoing SWL or URS for proximal ureteral stones.
[ "3" ]
153
39,667
0
false
In the current study, we examined subjective patient satisfaction with objective outcomes in patients undergoing SWL or URS for proximal ureteral stones.
[]
In the current study, we examined subjective patient satisfaction with objective outcomes in patients undergoing SWL or URS for proximal ureteral stones.
true
true
true
true
true
6,851
1
DISCUSSION
1
5
[ "B5", "B7", "B10", "B5", "B7", "B10", "B12", "B5", "B7", "B11", "B12" ]
21,165,201
pmid-17698126|pmid-11956420|NA|pmid-11956420|pmid-15893812|pmid-9895251|pmid-11956420|pmid-15893812|pmid-9895251|pmid-14499685|pmid-11956420|pmid-15893812|pmid-11061877|pmid-14499685
We found that the stone-free rates of URS and the cumulative stone-free rates of 3 sessions of SWL were comparable between the two groups (82.4% vs. 84.6%).
[ "5", "7", "10", "5", "7", "10", "12", "5", "7", "11", "12" ]
156
39,668
0
false
We found that the stone-free rates of URS and the cumulative stone-free rates of 3 sessions of SWL were comparable between the two groups (82.4% vs. 84.6%).
[]
We found that the stone-free rates of URS and the cumulative stone-free rates of 3 sessions of SWL were comparable between the two groups (82.4% vs. 84.6%).
true
true
true
true
true
6,852
1
DISCUSSION
1
5
[ "B5", "B7", "B10", "B5", "B7", "B10", "B12", "B5", "B7", "B11", "B12" ]
21,165,201
pmid-17698126|pmid-11956420|NA|pmid-11956420|pmid-15893812|pmid-9895251|pmid-11956420|pmid-15893812|pmid-9895251|pmid-14499685|pmid-11956420|pmid-15893812|pmid-11061877|pmid-14499685
In our study, the overall stone-free rate of URS was comparable to other studies with stone-free rates ranging from 75% to 93% [5-7,10], whereas the stone-free rate after initial SWL (37%) was relatively lower than in other studies with stone-free rates ranging from 50% to 86% [5-7,10-12].
[ "5", "7", "10", "5", "7", "10", "12", "5", "7", "11", "12" ]
290
39,669
0
false
In our study, the overall stone-free rate of URS was comparable to other studies with stone-free rates ranging from 75% to 93%, whereas the stone-free rate after initial SWL was relatively lower than in other studies with stone-free rates ranging from 50% to 86%.
[ "5-7,10", "37%", "5-7,10-12" ]
In our study, the overall stone-free rate of URS was comparable to other studies with stone-free rates ranging from 75% to 93%, whereas the stone-free rate after initial SWL was relatively lower than in other studies with stone-free rates ranging from 50% to 86%.
true
true
true
true
true
6,852
1
DISCUSSION
1
5
[ "B5", "B7", "B10", "B5", "B7", "B10", "B12", "B5", "B7", "B11", "B12" ]
21,165,201
pmid-17698126|pmid-11956420|NA|pmid-11956420|pmid-15893812|pmid-9895251|pmid-11956420|pmid-15893812|pmid-9895251|pmid-14499685|pmid-11956420|pmid-15893812|pmid-11061877|pmid-14499685
We suggest that this finding is mainly attributable to different SWL follow-up protocols.
[ "5", "7", "10", "5", "7", "10", "12", "5", "7", "11", "12" ]
89
39,670
0
false
We suggest that this finding is mainly attributable to different SWL follow-up protocols.
[]
We suggest that this finding is mainly attributable to different SWL follow-up protocols.
true
true
true
true
true
6,852
1
DISCUSSION
1
5
[ "B5", "B7", "B10", "B5", "B7", "B10", "B12", "B5", "B7", "B11", "B12" ]
21,165,201
pmid-17698126|pmid-11956420|NA|pmid-11956420|pmid-15893812|pmid-9895251|pmid-11956420|pmid-15893812|pmid-9895251|pmid-14499685|pmid-11956420|pmid-15893812|pmid-11061877|pmid-14499685
Most prior studies evaluated the stone-free rates of initial SWL at 1 month or 3 months after treatment [5-7,11,12], whereas we evaluated patients at 1 week after initial SWL and performed additional SWL in cases of residual stones.
[ "5", "7", "10", "5", "7", "10", "12", "5", "7", "11", "12" ]
232
39,671
0
false
Most prior studies evaluated the stone-free rates of initial SWL at 1 month or 3 months after treatment, whereas we evaluated patients at 1 week after initial SWL and performed additional SWL in cases of residual stones.
[ "5-7,11,12" ]
Most prior studies evaluated the stone-free rates of initial SWL at 1 month or 3 months after treatment, whereas we evaluated patients at 1 week after initial SWL and performed additional SWL in cases of residual stones.
true
true
true
true
true
6,852
2
DISCUSSION
1
5
[ "B5", "B7", "B13", "B5", "B7", "B14", "B17", "B14", "B16" ]
21,165,201
pmid-11956420|pmid-15893812|pmid-15596177|pmid-11956420|pmid-15893812|pmid-9895254|pmid-14744355|pmid-9895254|pmid-16527562
Notably, whereas the stone-free rates (93.8%) of URS for <10 mm proximal ureteral stones was similar to other series with stone-free rates from 90% to 100% [5,7,13], the stone-free rates in ≥10 mm proximal ureteral stones (55%) was much lower than in those recent series using holmium:YAG laser lithotripsy, for which st...
[ "5", "7", "13", "5", "7", "14", "17", "14", "16" ]
366
39,672
0
false
Notably, whereas the stone-free rates (93.8%) of URS for <10 mm proximal ureteral stones was similar to other series with stone-free rates from 90% to 100%, the stone-free rates in ≥10 mm proximal ureteral stones was much lower than in those recent series using holmium:YAG laser lithotripsy, for which stone-free rates ...
[ "5,7,13", "55%", "5-7" ]
Notably, whereas the stone-free rates (93.8%) of URS for <10 mm proximal ureteral stones was similar to other series with stone-free rates from 90% to 100%, the stone-free rates in ≥10 mm proximal ureteral stones was much lower than in those recent series using holmium:YAG laser lithotripsy, for which stone-free rates ...
true
true
true
true
true
6,853
2
DISCUSSION
1
5
[ "B5", "B7", "B13", "B5", "B7", "B14", "B17", "B14", "B16" ]
21,165,201
pmid-11956420|pmid-15893812|pmid-15596177|pmid-11956420|pmid-15893812|pmid-9895254|pmid-14744355|pmid-9895254|pmid-16527562
The lower stone-free rates in our patients undergoing URS for ≥10 mm proximal ureteral stones may be attributable to the following reasons.
[ "5", "7", "13", "5", "7", "14", "17", "14", "16" ]
139
39,673
0
false
The lower stone-free rates in our patients undergoing URS for ≥10 mm proximal ureteral stones may be attributable to the following reasons.
[]
The lower stone-free rates in our patients undergoing URS for ≥10 mm proximal ureteral stones may be attributable to the following reasons.
true
true
true
true
true
6,853
2
DISCUSSION
1
5
[ "B5", "B7", "B13", "B5", "B7", "B14", "B17", "B14", "B16" ]
21,165,201
pmid-11956420|pmid-15893812|pmid-15596177|pmid-11956420|pmid-15893812|pmid-9895254|pmid-14744355|pmid-9895254|pmid-16527562
First, most (82%) of our patients undergoing URS were treated with a pneumatic lithotripter, which is associated with an upward migration rate ranging from 5.5% to 33% [14-17].
[ "5", "7", "13", "5", "7", "14", "17", "14", "16" ]
176
39,674
0
false
First, most (82%) of our patients undergoing URS were treated with a pneumatic lithotripter, which is associated with an upward migration rate ranging from 5.5% to 33%.
[ "14-17" ]
First, most (82%) of our patients undergoing URS were treated with a pneumatic lithotripter, which is associated with an upward migration rate ranging from 5.5% to 33%.
true
true
true
true
true
6,853
2
DISCUSSION
1
14
[ "B5", "B7", "B13", "B5", "B7", "B14", "B17", "B14", "B16" ]
21,165,201
pmid-11956420|pmid-15893812|pmid-15596177|pmid-11956420|pmid-15893812|pmid-9895254|pmid-14744355|pmid-9895254|pmid-16527562
Knispel et al reported that only 51% of patients undergoing URS with the Swiss Lithoclast were stone-free immediately after URS because of frequent fragment migration [14].
[ "5", "7", "13", "5", "7", "14", "17", "14", "16" ]
172
39,675
1
false
Knispel et al reported that only 51% of patients undergoing URS with the Swiss Lithoclast were stone-free immediately after URS because of frequent fragment migration.
[ "14" ]
Knispel et al reported that only 51% of patients undergoing URS with the Swiss Lithoclast were stone-free immediately after URS because of frequent fragment migration.
true
true
true
true
true
6,853
2
DISCUSSION
1
16
[ "B5", "B7", "B13", "B5", "B7", "B14", "B17", "B14", "B16" ]
21,165,201
pmid-11956420|pmid-15893812|pmid-15596177|pmid-11956420|pmid-15893812|pmid-9895254|pmid-14744355|pmid-9895254|pmid-16527562
Lee et al also reported that only 35% of patients undergoing URS using a lithoclast or ultrasound lithotripter for large proximal ureteral stones ≥15 mm were stone-free after one session of URS [16].
[ "5", "7", "13", "5", "7", "14", "17", "14", "16" ]
199
39,676
1
false
Lee et al also reported that only 35% of patients undergoing URS using a lithoclast or ultrasound lithotripter for large proximal ureteral stones ≥15 mm were stone-free after one session of URS.
[ "16" ]
Lee et al also reported that only 35% of patients undergoing URS using a lithoclast or ultrasound lithotripter for large proximal ureteral stones ≥15 mm were stone-free after one session of URS.
true
true
true
true
true
6,853
2
DISCUSSION
1
5
[ "B5", "B7", "B13", "B5", "B7", "B14", "B17", "B14", "B16" ]
21,165,201
pmid-11956420|pmid-15893812|pmid-15596177|pmid-11956420|pmid-15893812|pmid-9895254|pmid-14744355|pmid-9895254|pmid-16527562
Second, we did not use any instruments during the study period, such as the N-trap, to prevent the fragmented fragments from migrating into the kidney.
[ "5", "7", "13", "5", "7", "14", "17", "14", "16" ]
151
39,677
0
false
Second, we did not use any instruments during the study period, such as the N-trap, to prevent the fragmented fragments from migrating into the kidney.
[]
Second, we did not use any instruments during the study period, such as the N-trap, to prevent the fragmented fragments from migrating into the kidney.
true
true
true
true
true
6,853
3
DISCUSSION
1
3
[ "B3", "B13" ]
21,165,201
pmid-17993340|pmid-15596177
Both the SWL and URS groups in this study had low overall complication rates, consistent with other reports [3,13].
[ "3", "13" ]
115
39,678
0
false
Both the SWL and URS groups in this study had low overall complication rates, consistent with other reports.
[ "3,13" ]
Both the SWL and URS groups in this study had low overall complication rates, consistent with other reports.
true
true
true
true
true
6,854
3
DISCUSSION
1
3
[ "B3", "B13" ]
21,165,201
pmid-17993340|pmid-15596177
The two groups were similar in complication rates except for greater steinstrasse in the SWL group.
[ "3", "13" ]
99
39,679
0
false
The two groups were similar in complication rates except for greater steinstrasse in the SWL group.
[]
The two groups were similar in complication rates except for greater steinstrasse in the SWL group.
true
true
true
true
true
6,854
3
DISCUSSION
1
3
[ "B3", "B13" ]
21,165,201
pmid-17993340|pmid-15596177
We believe that both treatment modalities can be performed without major complications in most proximal ureteral stones.
[ "3", "13" ]
120
39,680
0
false
We believe that both treatment modalities can be performed without major complications in most proximal ureteral stones.
[]
We believe that both treatment modalities can be performed without major complications in most proximal ureteral stones.
true
true
true
true
true
6,854
4
DISCUSSION
1
6
[ "B6", "B7", "B18" ]
21,165,201
pmid-15540749|pmid-15893812|pmid-7550267
In the present study, we examined overall patient satisfaction and also 4 domains of patient satisfaction.
[ "6", "7", "18" ]
106
39,681
0
false
In the present study, we examined overall patient satisfaction and also 4 domains of patient satisfaction.
[]
In the present study, we examined overall patient satisfaction and also 4 domains of patient satisfaction.
true
true
true
true
true
6,855
4
DISCUSSION
1
6
[ "B6", "B7", "B18" ]
21,165,201
pmid-15540749|pmid-15893812|pmid-7550267
Whereas overall patient satisfaction was comparable (Fig.
[ "6", "7", "18" ]
57
39,682
0
false
Whereas overall patient satisfaction was comparable (Fig.
[]
Whereas overall patient satisfaction was comparable (Fig.
true
true
true
true
true
6,855
4
DISCUSSION
1
6
[ "B6", "B7", "B18" ]
21,165,201
pmid-15540749|pmid-15893812|pmid-7550267
1), satisfaction rates in the 4 domains differed somewhat between the two groups (Table 4).
[ "6", "7", "18" ]
91
39,683
0
false
1), satisfaction rates in the 4 domains differed somewhat between the two groups (Table 4).
[]
1), satisfaction rates in the 4 domains differed somewhat between the two groups (Table 4).
false
false
true
true
false
6,855
4
DISCUSSION
1
6
[ "B6", "B7", "B18" ]
21,165,201
pmid-15540749|pmid-15893812|pmid-7550267
In the pain domain, the SWL group had a relatively lower satisfaction rate.
[ "6", "7", "18" ]
75
39,684
0
false
In the pain domain, the SWL group had a relatively lower satisfaction rate.
[]
In the pain domain, the SWL group had a relatively lower satisfaction rate.
true
true
true
true
true
6,855
4
DISCUSSION
1
6
[ "B6", "B7", "B18" ]
21,165,201
pmid-15540749|pmid-15893812|pmid-7550267
The reason for this finding may be attributable to the following reasons.
[ "6", "7", "18" ]
73
39,685
0
false
The reason for this finding may be attributable to the following reasons.
[]
The reason for this finding may be attributable to the following reasons.
true
true
true
true
true
6,855
4
DISCUSSION
1
6
[ "B6", "B7", "B18" ]
21,165,201
pmid-15540749|pmid-15893812|pmid-7550267
First, SWL was performed without sedation or anesthesia and thus the procedure itself caused more pain.
[ "6", "7", "18" ]
103
39,686
0
false
First, SWL was performed without sedation or anesthesia and thus the procedure itself caused more pain.
[]
First, SWL was performed without sedation or anesthesia and thus the procedure itself caused more pain.
true
true
true
true
true
6,855
4
DISCUSSION
1
6
[ "B6", "B7", "B18" ]
21,165,201
pmid-15540749|pmid-15893812|pmid-7550267
Second, despite the lesser invasiveness of SWL, it entails a relatively longer period until stone-free status is reached, consequently resulting in lesser satisfaction in the pain domain.
[ "6", "7", "18" ]
187
39,687
0
false
Second, despite the lesser invasiveness of SWL, it entails a relatively longer period until stone-free status is reached, consequently resulting in lesser satisfaction in the pain domain.
[]
Second, despite the lesser invasiveness of SWL, it entails a relatively longer period until stone-free status is reached, consequently resulting in lesser satisfaction in the pain domain.
true
true
true
true
true
6,855
4
DISCUSSION
1
6
[ "B6", "B7", "B18" ]
21,165,201
pmid-15540749|pmid-15893812|pmid-7550267
The slightly lower satisfaction rate in the voiding symptom domain of the URS group seems to have been due to irritation symptoms related to the double-J stent.
[ "6", "7", "18" ]
160
39,688
0
false
The slightly lower satisfaction rate in the voiding symptom domain of the URS group seems to have been due to irritation symptoms related to the double-J stent.
[]
The slightly lower satisfaction rate in the voiding symptom domain of the URS group seems to have been due to irritation symptoms related to the double-J stent.
true
true
true
true
true
6,855
4
DISCUSSION
1
6
[ "B6", "B7", "B18" ]
21,165,201
pmid-15540749|pmid-15893812|pmid-7550267
Although most prior studies have found URS to be more cost-effective than SWL in ureteral stones [6,7,18], our results showed similar satisfaction in the cost domain between the URS and SWL groups.
[ "6", "7", "18" ]
197
39,689
0
false
Although most prior studies have found URS to be more cost-effective than SWL in ureteral stones, our results showed similar satisfaction in the cost domain between the URS and SWL groups.
[ "6,7,18" ]
Although most prior studies have found URS to be more cost-effective than SWL in ureteral stones, our results showed similar satisfaction in the cost domain between the URS and SWL groups.
true
true
true
true
true
6,855
4
DISCUSSION
1
6
[ "B6", "B7", "B18" ]
21,165,201
pmid-15540749|pmid-15893812|pmid-7550267
Similarly, overall satisfaction with stone-free status was comparable between the two groups.
[ "6", "7", "18" ]
93
39,690
0
false
Similarly, overall satisfaction with stone-free status was comparable between the two groups.
[]
Similarly, overall satisfaction with stone-free status was comparable between the two groups.
true
true
true
true
true
6,855
4
DISCUSSION
1
6
[ "B6", "B7", "B18" ]
21,165,201
pmid-15540749|pmid-15893812|pmid-7550267
Overall, 94.1% and 90.4% of the URS and SWL groups scored satisfaction with their treatment method as ≥ 3 points (acceptable), which suggests that both methods are good treatment options for proximal ureteral stones (Fig.
[ "6", "7", "18" ]
221
39,691
0
false
Overall, 94.1% and 90.4% of the URS and SWL groups scored satisfaction with their treatment method as ≥ 3 points (acceptable), which suggests that both methods are good treatment options for proximal ureteral stones (Fig.
[]
Overall, 94.1% and 90.4% of the URS and SWL groups scored satisfaction with their treatment method as ≥ 3 points (acceptable), which suggests that both methods are good treatment options for proximal ureteral stones (Fig.
true
true
true
true
true
6,855
5
DISCUSSION
0
null
null
21,165,201
null
In the subgroup analysis based on stone size, satisfaction rates in the 4 domains for <10 mm stones showed a pattern similar to that of the entire patient population (Table 4).
null
176
39,692
0
false
null
null
In the subgroup analysis based on stone size, satisfaction rates in the 4 domains for <10 mm stones showed a pattern similar to that of the entire patient population (Table 4).
true
true
true
true
true
6,856
5
DISCUSSION
0
null
null
21,165,201
null
However, patients undergoing URS for ≥10 mm proximal ureteral stones had significantly lesser satisfaction with stone-free status.
null
130
39,693
0
false
null
null
However, patients undergoing URS for ≥10 mm proximal ureteral stones had significantly lesser satisfaction with stone-free status.
true
true
true
true
true
6,856
5
DISCUSSION
0
null
null
21,165,201
null
In addition, a trend toward lesser satisfaction in the cost domain in this URS subgroup was observed.
null
101
39,694
0
false
null
null
In addition, a trend toward lesser satisfaction in the cost domain in this URS subgroup was observed.
true
true
true
true
true
6,856
5
DISCUSSION
0
null
null
21,165,201
null
As expected, lower satisfaction with stone-free status in this subgroup of patients undergoing URS was mainly attributable to lower stone-free rates.
null
149
39,695
0
false
null
null
As expected, lower satisfaction with stone-free status in this subgroup of patients undergoing URS was mainly attributable to lower stone-free rates.
true
true
true
true
true
6,856
5
DISCUSSION
0
null
null
21,165,201
null
In our study, although it did not reach statistical significance, the overall satisfaction score in the URS group with ≥10 mm proximal ureteral stones was slightly lower than that of the SWL group (4.18±0.92 vs. 3.75±1.20).
null
223
39,696
0
false
null
null
In our study, although it did not reach statistical significance, the overall satisfaction score in the URS group with ≥10 mm proximal ureteral stones was slightly lower than that of the SWL group (4.18±0.92 vs. 3.75±1.20).
true
true
true
true
true
6,856
5
DISCUSSION
0
null
null
21,165,201
null
These findings also may be due to lesser satisfaction with stone-free status in this subgroup.
null
94
39,697
0
false
null
null
These findings also may be due to lesser satisfaction with stone-free status in this subgroup.
true
true
true
true
true
6,856
5
DISCUSSION
0
null
null
21,165,201
null
Our results for patient satisfaction in the subgroups with ≥10 mm proximal ureteral stones indicate that despite preoperative explanation of possible upward migration of stone fragments during URS with large stones, expectation of stone-free status may be greater in patients undergoing surgery than in those undergoing ...
null
324
39,698
0
false
null
null
Our results for patient satisfaction in the subgroups with ≥10 mm proximal ureteral stones indicate that despite preoperative explanation of possible upward migration of stone fragments during URS with large stones, expectation of stone-free status may be greater in patients undergoing surgery than in those undergoing ...
true
true
true
true
true
6,856
5
DISCUSSION
0
null
null
21,165,201
null
In addition, unless the possible necessity of ancillary procedures after URS for large proximal ureteral stones is explained, patient satisfaction may be much lower despite rapid symptomatic relief, compared with that of patients undergoing SWL.
null
245
39,699
0
false
null
null
In addition, unless the possible necessity of ancillary procedures after URS for large proximal ureteral stones is explained, patient satisfaction may be much lower despite rapid symptomatic relief, compared with that of patients undergoing SWL.
true
true
true
true
true
6,856
5
DISCUSSION
0
null
null
21,165,201
null
In this context, surgeons should be aware of high patient expectations for treatment success and reluctant patient attitudes toward ancillary treatment after surgery.
null
166
39,700
0
false
null
null
In this context, surgeons should be aware of high patient expectations for treatment success and reluctant patient attitudes toward ancillary treatment after surgery.
true
true
true
true
true
6,856
6
DISCUSSION
1
19
[ "B19" ]
21,165,201
pmid-12576846
We acknowledge that our results have possible biases.
[ "19" ]
53
39,701
0
false
We acknowledge that our results have possible biases.
[]
We acknowledge that our results have possible biases.
true
true
true
true
true
6,857
6
DISCUSSION
1
19
[ "B19" ]
21,165,201
pmid-12576846
Most importantly, we did not use validated questionnaires.
[ "19" ]
58
39,702
0
false
Most importantly, we did not use validated questionnaires.
[]
Most importantly, we did not use validated questionnaires.
true
true
true
true
true
6,857
6
DISCUSSION
1
19
[ "B19" ]
21,165,201
pmid-12576846
To date, several validated questionnaires are being used to assess general quality of life (QoL) (such as SF-36 and EuroQol) and stent-related QoL (such as the ureteral stent symptom questionnaire [19]).
[ "19" ]
203
39,703
0
false
To date, several validated questionnaires are being used to assess general quality of life (QoL) (such as SF-36 and EuroQol) and stent-related QoL.
[ "such as the ureteral stent symptom questionnaire [19]" ]
To date, several validated questionnaires are being used to assess general quality of life (QoL) (such as SF-36 and EuroQol) and stent-related QoL.
true
true
true
true
true
6,857
6
DISCUSSION
1
19
[ "B19" ]
21,165,201
pmid-12576846
However, so far, there is no validated questionnaire for measuring subjective satisfaction specific to proximal ureteral stones.
[ "19" ]
128
39,704
0
false
However, so far, there is no validated questionnaire for measuring subjective satisfaction specific to proximal ureteral stones.
[]
However, so far, there is no validated questionnaire for measuring subjective satisfaction specific to proximal ureteral stones.
true
true
true
true
true
6,857
6
DISCUSSION
1
19
[ "B19" ]
21,165,201
pmid-12576846
We assessed patient perception with our specifically tailored questionnaire because several validated questionnaires for general QoL are not enough to discriminate satisfaction in patients undergoing URS or SWL for proximal ureteral stones.
[ "19" ]
240
39,705
0
false
We assessed patient perception with our specifically tailored questionnaire because several validated questionnaires for general QoL are not enough to discriminate satisfaction in patients undergoing URS or SWL for proximal ureteral stones.
[]
We assessed patient perception with our specifically tailored questionnaire because several validated questionnaires for general QoL are not enough to discriminate satisfaction in patients undergoing URS or SWL for proximal ureteral stones.
true
true
true
true
true
6,857
6
DISCUSSION
1
19
[ "B19" ]
21,165,201
pmid-12576846
In addition, because our study was retrospective, we examined patient satisfaction at the time of ultimate stone-free status.
[ "19" ]
125
39,706
0
false
In addition, because our study was retrospective, we examined patient satisfaction at the time of ultimate stone-free status.
[]
In addition, because our study was retrospective, we examined patient satisfaction at the time of ultimate stone-free status.
true
true
true
true
true
6,857
6
DISCUSSION
1
19
[ "B19" ]
21,165,201
pmid-12576846
The time of examining the questionnaire may affect the results regarding patient satisfaction.
[ "19" ]
94
39,707
0
false
The time of examining the questionnaire may affect the results regarding patient satisfaction.
[]
The time of examining the questionnaire may affect the results regarding patient satisfaction.
true
true
true
true
true
6,857
6
DISCUSSION
1
19
[ "B19" ]
21,165,201
pmid-12576846
Nevertheless, we believe that our results analyzing patient perception as well as objective treatment outcomes highlight the importance of subjective patient satisfaction as one of the considerations in determining the treatment method for proximal ureteral stones.
[ "19" ]
265
39,708
0
false
Nevertheless, we believe that our results analyzing patient perception as well as objective treatment outcomes highlight the importance of subjective patient satisfaction as one of the considerations in determining the treatment method for proximal ureteral stones.
[]
Nevertheless, we believe that our results analyzing patient perception as well as objective treatment outcomes highlight the importance of subjective patient satisfaction as one of the considerations in determining the treatment method for proximal ureteral stones.
true
true
true
true
true
6,857
6
DISCUSSION
1
19
[ "B19" ]
21,165,201
pmid-12576846
Besides analyzing objective outcomes, further study focusing on patient QoL and satisfaction with the use of an appropriate, validated questionnaire is warranted to determine the optimal treatment method for proximal ureteral stones.
[ "19" ]
233
39,709
0
false
Besides analyzing objective outcomes, further study focusing on patient QoL and satisfaction with the use of an appropriate, validated questionnaire is warranted to determine the optimal treatment method for proximal ureteral stones.
[]
Besides analyzing objective outcomes, further study focusing on patient QoL and satisfaction with the use of an appropriate, validated questionnaire is warranted to determine the optimal treatment method for proximal ureteral stones.
true
true
true
true
true
6,857
0
INTRODUCTION
1
Catterall, 2000
[ "bib4", "bib6", "bib32", "bib17", "bib20", "bib25", "bib26", "bib18" ]
19,687,230
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
The pore-forming α1 subunits of Ca channels (CaV) are composed of four homologous domains (I–IV) formed by six transmembrane segments (S1–S6) that are linked together on a single polypeptide (Catterall, 2000).
[ "Catterall, 2000", "Doyle et al., 1998", "Zhou et al., 2001", "Jiang et al., 2002", "Long et al., 2005", "Swartz, 2005", "Tombola et al., 2006", "Jiang et al., 2003" ]
209
39,710
1
false
The pore-forming α1 subunits of Ca channels (CaV) are composed of four homologous domains (I–IV) formed by six transmembrane segments (S1–S6) that are linked together on a single polypeptide.
[ "Catterall, 2000" ]
The pore-forming α1 subunits of Ca channels are composed of four homologous domains (I–IV) formed by six transmembrane segments (S1–S6) that are linked together on a single polypeptide.
true
true
true
true
true
6,858
0
INTRODUCTION
1
Catterall, 2000
[ "bib4", "bib6", "bib32", "bib17", "bib20", "bib25", "bib26", "bib18" ]
19,687,230
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
In analogy to potassium channels (Doyle et al., 1998; Zhou et al., 2001; Jiang et al., 2002; Long et al., 2005; Swartz, 2005; Tombola et al., 2006), it is assumed that S6 segments line the channel pore, with an S6 bundle-crossing region in the lower third forming the channel gate.
[ "Catterall, 2000", "Doyle et al., 1998", "Zhou et al., 2001", "Jiang et al., 2002", "Long et al., 2005", "Swartz, 2005", "Tombola et al., 2006", "Jiang et al., 2003" ]
281
39,711
0
false
In analogy to potassium channels, it is assumed that S6 segments line the channel pore, with an S6 bundle-crossing region in the lower third forming the channel gate.
[ "Doyle et al., 1998; Zhou et al., 2001; Jiang et al., 2002; Long et al., 2005; Swartz, 2005; Tombola et al., 2006" ]
In analogy to potassium channels, it is assumed that S6 segments line the channel pore, with an S6 bundle-crossing region in the lower third forming the channel gate.
true
true
true
true
true
6,858
0
INTRODUCTION
1
Catterall, 2000
[ "bib4", "bib6", "bib32", "bib17", "bib20", "bib25", "bib26", "bib18" ]
19,687,230
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Unlike potassium channels, which are composed of four identical units, CaV are asymmetric.
[ "Catterall, 2000", "Doyle et al., 1998", "Zhou et al., 2001", "Jiang et al., 2002", "Long et al., 2005", "Swartz, 2005", "Tombola et al., 2006", "Jiang et al., 2003" ]
90
39,712
0
false
Unlike potassium channels, which are composed of four identical units, CaV are asymmetric.
[]
Unlike potassium channels, which are composed of four identical units, CaV are asymmetric.
true
true
true
true
true
6,858
0
INTRODUCTION
1
Jiang et al., 2003
[ "bib4", "bib6", "bib32", "bib17", "bib20", "bib25", "bib26", "bib18" ]
19,687,230
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
None of the four S6 segments carries a PXP motif like Shaker, and a conserved G89 in MthK (Jiang et al., 2003) is present only in segments IS6 and IIS6.
[ "Catterall, 2000", "Doyle et al., 1998", "Zhou et al., 2001", "Jiang et al., 2002", "Long et al., 2005", "Swartz, 2005", "Tombola et al., 2006", "Jiang et al., 2003" ]
152
39,713
1
false
None of the four S6 segments carries a PXP motif like Shaker, and a conserved G89 in MthK is present only in segments IS6 and IIS6.
[ "Jiang et al., 2003" ]
None of the four S6 segments carries a PXP motif like Shaker, and a conserved G89 in MthK is present only in segments IS6 and IIS6.
true
true
true
true
true
6,858
1
INTRODUCTION
1
Hemara-Wahanui et al., 2005
[ "bib12", "bib15", "bib13", "bib24", "bib28", "bib31" ]
19,687,230
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
We have recently identified a motif of hydrophobic residues in the lower third of segment IIS6 that is conserved in high voltage–activated CaV1.2 and plays an important role in activation gating (779–782: LAIA; see Hemara-Wahanui et al., 2005; Hohaus et al., 2005).
[ "Hemara-Wahanui et al., 2005", "Hohaus et al., 2005", "Hering et al., 2008", "Stary et al., 2008", "Yifrach and MacKinnon, 2002", "Zhao et al., 2004" ]
265
39,714
0
false
We have recently identified a motif of hydrophobic residues in the lower third of segment IIS6 that is conserved in high voltage–activated CaV1.2 and plays an important role in activation gating.
[ "779–782: LAIA; see Hemara-Wahanui et al., 2005; Hohaus et al., 2005" ]
We have recently identified a motif of hydrophobic residues in the lower third of segment IIS6 that is conserved in high voltage–activated CaV1.2 and plays an important role in activation gating.
true
true
true
true
true
6,859
1
INTRODUCTION
1
Hemara-Wahanui et al., 2005
[ "bib12", "bib15", "bib13", "bib24", "bib28", "bib31" ]
19,687,230
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Replacement of these IIS6 residues by amino acids of different hydrophobicity, size, and polarity induced pronounced changes in channel gating, such as shifts in the voltage dependence of activation, slow activation kinetics near the footstep of the activation curve, slow deactivation at all potentials, and decreased i...
[ "Hemara-Wahanui et al., 2005", "Hohaus et al., 2005", "Hering et al., 2008", "Stary et al., 2008", "Yifrach and MacKinnon, 2002", "Zhao et al., 2004" ]
392
39,715
0
false
Replacement of these IIS6 residues by amino acids of different hydrophobicity, size, and polarity induced pronounced changes in channel gating, such as shifts in the voltage dependence of activation, slow activation kinetics near the footstep of the activation curve, slow deactivation at all potentials, and decreased i...
[ "for review see Hering et al., 2008 and Stary et al., 2008" ]
Replacement of these IIS6 residues by amino acids of different hydrophobicity, size, and polarity induced pronounced changes in channel gating, such as shifts in the voltage dependence of activation, slow activation kinetics near the footstep of the activation curve, slow deactivation at all potentials, and decreased i...
true
true
true
true
true
6,859