Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
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 Community
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INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B6" ]
18,162,708
pmid-3056758|pmid-9279450|pmid-8971083|pmid-9686693|pmid-11368702|NA|pmid-9603539|pmid-3056758|pmid-9279450|NA
In this report, the components and criteria were set up more succinctly than those of the WHO.
[ "1", "2", "3", "4", "5", "6" ]
94
39,516
0
false
In this report, the components and criteria were set up more succinctly than those of the WHO.
[]
In this report, the components and criteria were set up more succinctly than those of the WHO.
true
true
true
true
true
6,818
0
INTRODUCTION
1
6
[ "B1", "B2", "B3", "B4", "B5", "B6" ]
18,162,708
pmid-3056758|pmid-9279450|pmid-8971083|pmid-9686693|pmid-11368702|NA|pmid-9603539|pmid-3056758|pmid-9279450|NA
In 2002, the American College of Endocrinology/American Association of Clinical Endocrinologists (ACE/AACE) suggested new diagnostic criteria for metabolic syndrome that highlighted the role of insulin resistance (6).
[ "1", "2", "3", "4", "5", "6" ]
217
39,517
1
false
In 2002, the American College of Endocrinology/American Association of Clinical Endocrinologists (ACE/AACE) suggested new diagnostic criteria for metabolic syndrome that highlighted the role of insulin resistance.
[ "6" ]
In 2002, the American College of Endocrinology/American Association of Clinical Endocrinologists (ACE/AACE) suggested new diagnostic criteria for metabolic syndrome that highlighted the role of insulin resistance.
true
true
true
true
true
6,818
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5", "B6" ]
18,162,708
pmid-3056758|pmid-9279450|pmid-8971083|pmid-9686693|pmid-11368702|NA|pmid-9603539|pmid-3056758|pmid-9279450|NA
These clinical diagnostic criteria were simplified to be applied more easily.
[ "1", "2", "3", "4", "5", "6" ]
77
39,518
0
false
These clinical diagnostic criteria were simplified to be applied more easily.
[]
These clinical diagnostic criteria were simplified to be applied more easily.
true
true
true
true
true
6,818
1
INTRODUCTION
1
7
[ "B7" ]
18,162,708
pmid-1884900
In the San Antonio Study (7), which is the representative epidemiological study that supports the concept of IRS, the prevalence of obesity, type 2 diabetes, impaired glucose intolerance, hypertension, hypertriglyceridemia, and hypercholesterolemia among 2,930 people was investigated.
[ "7" ]
285
39,519
1
false
In the San Antonio Study, which is the representative epidemiological study that supports the concept of IRS, the prevalence of obesity, type 2 diabetes, impaired glucose intolerance, hypertension, hypertriglyceridemia, and hypercholesterolemia among 2,930 people was investigated.
[ "7" ]
In the San Antonio Study, which is the representative epidemiological study that supports the concept of IRS, the prevalence of obesity, type 2 diabetes, impaired glucose intolerance, hypertension, hypertriglyceridemia, and hypercholesterolemia among 2,930 people was investigated.
true
true
true
true
true
6,819
1
INTRODUCTION
1
7
[ "B7" ]
18,162,708
pmid-1884900
Among the 2,930 participants, results obtained from 1,881 (64%) people who had at least one disease showed that the insulin concentration in serum, both fasting and after glucose tolerance, was positively associated with body mass index (BMI), systolic and diastolic pressure, and the concentration of both triglyceride ...
[ "7" ]
351
39,520
0
false
Among the 2,930 participants, results obtained from 1,881 (64%) people who had at least one disease showed that the insulin concentration in serum, both fasting and after glucose tolerance, was positively associated with body mass index (BMI), systolic and diastolic pressure, and the concentration of both triglyceride ...
[]
Among the 2,930 participants, results obtained from 1,881 (64%) people who had at least one disease showed that the insulin concentration in serum, both fasting and after glucose tolerance, was positively associated with body mass index (BMI), systolic and diastolic pressure, and the concentration of both triglyceride ...
true
true
true
true
true
6,819
1
INTRODUCTION
1
7
[ "B7" ]
18,162,708
pmid-1884900
Furthermore, serum insulin was positively associated with the concentration of low high-density lipoprotein (HDL) cholesterol.
[ "7" ]
126
39,521
0
false
Furthermore, serum insulin was positively associated with the concentration of low high-density lipoprotein (HDL) cholesterol.
[]
Furthermore, serum insulin was positively associated with the concentration of low high-density lipoprotein (HDL) cholesterol.
true
true
true
true
true
6,819
1
INTRODUCTION
1
7
[ "B7" ]
18,162,708
pmid-1884900
From these data, it was concluded that these diseases were significantly correlated with both fasting and post-prandial insulin concentration in serum, due to the strong association between hyperinsulinemia and insulin resistance.
[ "7" ]
230
39,522
0
false
From these data, it was concluded that these diseases were significantly correlated with both fasting and post-prandial insulin concentration in serum, due to the strong association between hyperinsulinemia and insulin resistance.
[]
From these data, it was concluded that these diseases were significantly correlated with both fasting and post-prandial insulin concentration in serum, due to the strong association between hyperinsulinemia and insulin resistance.
true
true
true
true
true
6,819
2
INTRODUCTION
0
null
null
18,162,708
pmid-3883799|pmid-11333990
IRS, which causes serious clinical manifestations and is associated with cardiovascular disease and type 2 diabetes, is remarkable not only in the fields of endocrinology and cardiology, but also is becoming one of the most important problems in public health.
null
260
39,523
0
false
null
null
IRS, which causes serious clinical manifestations and is associated with cardiovascular disease and type 2 diabetes, is remarkable not only in the fields of endocrinology and cardiology, but also is becoming one of the most important problems in public health.
true
true
true
true
true
6,820
2
INTRODUCTION
0
null
null
18,162,708
pmid-3883799|pmid-11333990
It was estimated that IRS in populations with risk factors of cardiovascular disease will increase gradually with expansion of the obese population in the future.
null
162
39,524
0
false
null
null
It was estimated that IRS in populations with risk factors of cardiovascular disease will increase gradually with expansion of the obese population in the future.
true
true
true
true
true
6,820
2
INTRODUCTION
0
null
null
18,162,708
pmid-3883799|pmid-11333990
There were no researches that applied the renewed diagnostic criteria of the ACE/AACE, and it was difficult to find a study of the incidence of IRS in Korea.
null
157
39,525
0
false
null
null
There were no researches that applied the renewed diagnostic criteria of the ACE/AACE, and it was difficult to find a study of the incidence of IRS in Korea.
true
true
true
true
true
6,820
3
INTRODUCTION
0
null
null
18,162,708
NA|NA
Therefore, we determined the incidence of IRS based on the diagnostic criteria of the ACE/AACE and the risk factors that influence its development.
null
147
39,526
0
false
null
null
Therefore, we determined the incidence of IRS based on the diagnostic criteria of the ACE/AACE and the risk factors that influence its development.
true
true
true
true
true
6,821
0
DISCUSSION
1
8
[ "B8", "B1", "B2", "B9" ]
18,162,708
pmid-3056758|pmid-9279450|pmid-8971083|pmid-9686693|pmid-11368702|NA|pmid-9603539|pmid-3056758|pmid-9279450|NA
Age, smoking, hypertension, high LDL cholesterol, low HDL cholesterol, high blood sugar, lack of physical activity, and blood coagulation times are known risk factors for cardiovascular disease (8).
[ "8", "1", "2", "9" ]
198
39,527
1
false
Age, smoking, hypertension, high LDL cholesterol, low HDL cholesterol, high blood sugar, lack of physical activity, and blood coagulation times are known risk factors for cardiovascular disease.
[ "8" ]
Age, smoking, hypertension, high LDL cholesterol, low HDL cholesterol, high blood sugar, lack of physical activity, and blood coagulation times are known risk factors for cardiovascular disease.
true
true
true
true
true
6,822
0
DISCUSSION
1
9
[ "B8", "B1", "B2", "B9" ]
18,162,708
pmid-3056758|pmid-9279450|pmid-8971083|pmid-9686693|pmid-11368702|NA|pmid-9603539|pmid-3056758|pmid-9279450|NA
The combination of these factors in an individual (1, 2) and the decline of glucose metabolism are recognized as the basis of IRS (9).
[ "8", "1", "2", "9" ]
134
39,528
1
false
The combination of these factors in an individual and the decline of glucose metabolism are recognized as the basis of IRS.
[ "1, 2", "9" ]
The combination of these factors in an individual and the decline of glucose metabolism are recognized as the basis of IRS.
true
true
true
true
true
6,822
0
DISCUSSION
1
8
[ "B8", "B1", "B2", "B9" ]
18,162,708
pmid-3056758|pmid-9279450|pmid-8971083|pmid-9686693|pmid-11368702|NA|pmid-9603539|pmid-3056758|pmid-9279450|NA
Specifically, the ACE/AACE stated in 2003 that IRS was a clinical result of insulin resistance and its compensatory mechanism.
[ "8", "1", "2", "9" ]
126
39,529
0
false
Specifically, the ACE/AACE stated in 2003 that IRS was a clinical result of insulin resistance and its compensatory mechanism.
[]
Specifically, the ACE/AACE stated in 2003 that IRS was a clinical result of insulin resistance and its compensatory mechanism.
true
true
true
true
true
6,822
1
DISCUSSION
0
null
null
18,162,708
pmid-1884900
In this study, the age-adjusted annual incidence was 6.7 per 100 persons, which is considered to be relatively high.
null
116
39,530
0
false
null
null
In this study, the age-adjusted annual incidence was 6.7 per 100 persons, which is considered to be relatively high.
true
true
true
true
true
6,823
1
DISCUSSION
0
null
null
18,162,708
pmid-1884900
The age group 20-29 showed the lowest incidence of 4.6 per 100 persons/year, while the age group 40-49 showed the highest incidence of 9.0 per 100 persons/year.
null
160
39,531
0
false
null
null
The age group 20-29 showed the lowest incidence of 4.6 per 100 persons/year, while the age group 40-49 showed the highest incidence of 9.0 per 100 persons/year.
true
true
true
true
true
6,823
1
DISCUSSION
0
null
null
18,162,708
pmid-1884900
However, the incidence in the age group 50-59 had decreased to 6.6 per 100 persons/year.
null
88
39,532
0
false
null
null
However, the incidence in the age group 50-59 had decreased to 6.6 per 100 persons/year.
true
true
true
true
true
6,823
1
DISCUSSION
0
null
null
18,162,708
pmid-1884900
The reasons for the decrease in incidence for this age group are thought to be as follows: 1) the number of subjects who were in their 50s was small, and 2) people in their 50s who were found to have IRS at the insulin resistance syndrome screening test had demonstrated evidence of IRS earlier in life.
null
303
39,533
0
false
null
null
The reasons for the decrease in incidence for this age group are thought to be as follows: 1) the number of subjects who were in their 50s was small, and 2) people in their 50s who were found to have IRS at the insulin resistance syndrome screening test had demonstrated evidence of IRS earlier in life.
true
true
true
true
true
6,823
1
DISCUSSION
0
null
null
18,162,708
pmid-1884900
The RR for the 40-49 age group compared to the 20-29 age group was 1.95 (95% CI 1.10-3.46).
null
91
39,534
0
false
null
null
The RR for the 40-49 age group compared to the 20-29 age group was 1.95 (95% CI 1.10-3.46).
true
true
true
true
true
6,823
1
DISCUSSION
0
null
null
18,162,708
pmid-1884900
Thus, the RR in the logistic regression analysis was increased 1.03 times (95% CI 1.00-1.05) with age, with every one-year increase.
null
132
39,535
0
false
null
null
Thus, the RR in the logistic regression analysis was increased 1.03 times (95% CI 1.00-1.05) with age, with every one-year increase.
true
true
true
true
true
6,823
2
DISCUSSION
1
10
[ "B10", "B11" ]
18,162,708
pmid-3883799|pmid-11333990
The environmental factors involved in the development of IRS include mental stress, lack of exercise, and visceral obesity in addition to age as mentioned above (10).
[ "10", "11" ]
166
39,536
1
false
The environmental factors involved in the development of IRS include mental stress, lack of exercise, and visceral obesity in addition to age as mentioned above.
[ "10" ]
The environmental factors involved in the development of IRS include mental stress, lack of exercise, and visceral obesity in addition to age as mentioned above.
true
true
true
true
true
6,824
2
DISCUSSION
1
11
[ "B10", "B11" ]
18,162,708
pmid-3883799|pmid-11333990
WHR, smoking, LDL cholesterol and abnormal ALT showed significant association with IRS, after adjusting for several relevant factors in this study as well as in a previous study (11).
[ "10", "11" ]
183
39,537
1
false
WHR, smoking, LDL cholesterol and abnormal ALT showed significant association with IRS, after adjusting for several relevant factors in this study as well as in a previous study.
[ "11" ]
WHR, smoking, LDL cholesterol and abnormal ALT showed significant association with IRS, after adjusting for several relevant factors in this study as well as in a previous study.
true
true
true
true
true
6,824
3
DISCUSSION
1
12
[ "B12", "B13" ]
18,162,708
NA|NA
It is well known that obesity is closely associated with IRS, and that the accumulation of visceral fat correlates with the development of IRS.
[ "12", "13" ]
143
39,538
0
false
It is well known that obesity is closely associated with IRS, and that the accumulation of visceral fat correlates with the development of IRS.
[]
It is well known that obesity is closely associated with IRS, and that the accumulation of visceral fat correlates with the development of IRS.
true
true
true
true
true
6,825
3
DISCUSSION
1
12
[ "B12", "B13" ]
18,162,708
NA|NA
With regard to the correlation between IRS and WHR, which is the index of abdominal obesity, had a more significant correlation than BMI (12).
[ "12", "13" ]
142
39,539
1
false
With regard to the correlation between IRS and WHR, which is the index of abdominal obesity, had a more significant correlation than BMI.
[ "12" ]
With regard to the correlation between IRS and WHR, which is the index of abdominal obesity, had a more significant correlation than BMI.
true
true
true
true
true
6,825
3
DISCUSSION
1
13
[ "B12", "B13" ]
18,162,708
NA|NA
Heo and colleagues (13) reported that there was a significant correlation between visceral fat area measured by computerized axial tomography and insulin sensitivity.
[ "12", "13" ]
166
39,540
1
false
Heo and colleagues reported that there was a significant correlation between visceral fat area measured by computerized axial tomography and insulin sensitivity.
[ "13" ]
Heo and colleagues reported that there was a significant correlation between visceral fat area measured by computerized axial tomography and insulin sensitivity.
true
true
true
true
true
6,825
3
DISCUSSION
1
12
[ "B12", "B13" ]
18,162,708
NA|NA
In this study, the RR for the abdominal obesity group in which WHR was 0.9 or higher was 2.13 (95% CI, 1.64-2.77), showing a significant association with IRS development.
[ "12", "13" ]
170
39,541
0
false
In this study, the RR for the abdominal obesity group in which WHR was 0.9 or higher was 2.13 (95% CI, 1.64-2.77), showing a significant association with IRS development.
[]
In this study, the RR for the abdominal obesity group in which WHR was 0.9 or higher was 2.13, showing a significant association with IRS development.
true
true
true
true
true
6,825
4
DISCUSSION
1
10
[ "B10", "B14" ]
18,162,708
pmid-3883799|pmid-6341123
It is known that both obesity and lack of physical activity account for about 25% of the cause of insulin resistance (10).
[ "10", "14" ]
122
39,542
1
false
It is known that both obesity and lack of physical activity account for about 25% of the cause of insulin resistance.
[ "10" ]
It is known that both obesity and lack of physical activity account for about 25% of the cause of insulin resistance.
true
true
true
true
true
6,826
4
DISCUSSION
1
14
[ "B10", "B14" ]
18,162,708
pmid-3883799|pmid-6341123
The amount of physical activity is known to be closely related to insulin sensitivity, and maximum oxygen consumption is a factor that determines about 25% of insulin sensitivity in normal adults without type 2 diabetes (14).
[ "10", "14" ]
225
39,543
1
false
The amount of physical activity is known to be closely related to insulin sensitivity, and maximum oxygen consumption is a factor that determines about 25% of insulin sensitivity in normal adults without type 2 diabetes.
[ "14" ]
The amount of physical activity is known to be closely related to insulin sensitivity, and maximum oxygen consumption is a factor that determines about 25% of insulin sensitivity in normal adults without type 2 diabetes.
true
true
true
true
true
6,826
4
DISCUSSION
1
10
[ "B10", "B14" ]
18,162,708
pmid-3883799|pmid-6341123
In this study, there was no significant difference in the incidence of IRS between the regular exercise group (exercised three or more times a week for 30 or more minutes at each time) and the non-regular exercise group, but the insulin concentration in blood after one year in the regular exercise was statistically sig...
[ "10", "14" ]
475
39,544
0
false
In this study, there was no significant difference in the incidence of IRS between the regular exercise group (exercised three or more times a week for 30 or more minutes at each time) and the non-regular exercise group, but the insulin concentration in blood after one year in the regular exercise was statistically sig...
[]
In this study, there was no significant difference in the incidence of IRS between the regular exercise group and the non-regular exercise group, but the insulin concentration in blood after one year in the regular exercise was statistically significant lower than that of the non-regular exercise group.
true
true
true
true
true
6,826
4
DISCUSSION
1
10
[ "B10", "B14" ]
18,162,708
pmid-3883799|pmid-6341123
In this study, the RR of insulin resistance syndrome for the smoking group was 1.56 (95% CI, 1.11-2.19).
[ "10", "14" ]
104
39,545
0
false
In this study, the RR of insulin resistance syndrome for the smoking group was 1.56 (95% CI, 1.11-2.19).
[]
In this study, the RR of insulin resistance syndrome for the smoking group was 1.56.
true
true
true
true
true
6,826
4
DISCUSSION
1
10
[ "B10", "B14" ]
18,162,708
pmid-3883799|pmid-6341123
After other risk factors were adjusted, the RR was 1.63 (95% CI, 1.09-2.42).
[ "10", "14" ]
76
39,546
0
false
After other risk factors were adjusted, the RR was 1.63 (95% CI, 1.09-2.42).
[]
After other risk factors were adjusted, the RR was 1.63.
true
true
true
true
true
6,826
4
DISCUSSION
1
10
[ "B10", "B14" ]
18,162,708
pmid-3883799|pmid-6341123
Moreover, insulin concentrations in the plasma of the smoking group were statistically significantly higher than in the non-smoking group in this study (smoking group: 7.03±6.94 µIU/mL, non-smoking group: 6.38±6.04 µIU/mL, p<0.05).
[ "10", "14" ]
231
39,547
0
false
Moreover, insulin concentrations in the plasma of the smoking group were statistically significantly higher than in the non-smoking group in this study (smoking group: 7.03±6.94 µIU/mL, non-smoking group: 6.38±6.04 µIU/mL, p<0.05).
[]
Moreover, insulin concentrations in the plasma of the smoking group were statistically significantly higher than in the non-smoking group in this study.
true
true
true
true
true
6,826
5
DISCUSSION
1
15
[ "B15", "B16", "B17" ]
18,162,708
pmid-9698022|pmid-2372896|pmid-8325978
Godsland and colleagues (15) reported that insulin resistance is caused by the acute effect of smoking in the case of current smokers.
[ "15", "16", "17" ]
134
39,548
1
false
Godsland and colleagues reported that insulin resistance is caused by the acute effect of smoking in the case of current smokers.
[ "15" ]
Godsland and colleagues reported that insulin resistance is caused by the acute effect of smoking in the case of current smokers.
true
true
true
true
true
6,827
5
DISCUSSION
1
15
[ "B15", "B16", "B17" ]
18,162,708
pmid-9698022|pmid-2372896|pmid-8325978
The RR for the group in which LDL cholesterol concentration was higher than 130 mg/dL but lower than 160 mg/dL and the group in which LDL cholesterol concentration was 160 mg/dL or higher were 1.44 (95% CI, 1.06-1.95) and
[ "15", "16", "17" ]
221
39,549
0
false
The RR for the group in which LDL cholesterol concentration was higher than 130 mg/dL but lower than 160 mg/dL and the group in which LDL cholesterol concentration was 160 mg/dL or higher were 1.44 (95% CI, 1.06-1.95) and
[]
The RR for the group in which LDL cholesterol concentration was higher than 130 mg/dL but lower than 160 mg/dL and the group in which LDL cholesterol concentration was 160 mg/dL or higher were 1.44 and
true
true
false
true
false
6,827
5
DISCUSSION
1
15
[ "B15", "B16", "B17" ]
18,162,708
pmid-9698022|pmid-2372896|pmid-8325978
4.77 (95% CI, 3.47-6.56), respectively, compared to the group in which LDL cholesterol concentration was 130 mg/dL or lower.
[ "15", "16", "17" ]
124
39,550
0
false
4.77 (95% CI, 3.47-6.56), respectively, compared to the group in which LDL cholesterol concentration was 130 mg/dL or lower.
[]
4.77, respectively, compared to the group in which LDL cholesterol concentration was 130 mg/dL or lower.
false
false
true
true
false
6,827
5
DISCUSSION
1
15
[ "B15", "B16", "B17" ]
18,162,708
pmid-9698022|pmid-2372896|pmid-8325978
Furthermore, using logistic regression analysis in which other risk factors were adjusted, the RR for the group of which LDL cholesterol concentration was 160 mg/dL or higher was 1.70 (95% CI, 1.19-2.44).
[ "15", "16", "17" ]
204
39,551
0
false
Furthermore, using logistic regression analysis in which other risk factors were adjusted, the RR for the group of which LDL cholesterol concentration was 160 mg/dL or higher was 1.70 (95% CI, 1.19-2.44).
[]
Furthermore, using logistic regression analysis in which other risk factors were adjusted, the RR for the group of which LDL cholesterol concentration was 160 mg/dL or higher was 1.70.
true
true
true
true
true
6,827
5
DISCUSSION
1
16
[ "B15", "B16", "B17" ]
18,162,708
pmid-9698022|pmid-2372896|pmid-8325978
It was recently found that small dense LDL cholesterol is a main factor of atherosclerosis (16) and is associated with insulin resistance (17); therefore, it is thought that disorder in lipid metabolism due to insulin resistance plays an important role in the development of atherosclerosis.
[ "15", "16", "17" ]
291
39,552
1
false
It was recently found that small dense LDL cholesterol is a main factor of atherosclerosis and is associated with insulin resistance ; therefore, it is thought that disorder in lipid metabolism due to insulin resistance plays an important role in the development of atherosclerosis.
[ "16", "17" ]
It was recently found that small dense LDL cholesterol is a main factor of atherosclerosis and is associated with insulin resistance ; therefore, it is thought that disorder in lipid metabolism due to insulin resistance plays an important role in the development of atherosclerosis.
true
true
true
true
true
6,827
6
DISCUSSION
1
18
[ "B18", "B18" ]
18,162,708
pmid-12031978|pmid-12031978
Abnormal liver function was significantly associated with development of IRS, after viral hepatitis was excluded (18).
[ "18", "18" ]
118
39,553
1
false
Abnormal liver function was significantly associated with development of IRS, after viral hepatitis was excluded.
[ "18" ]
Abnormal liver function was significantly associated with development of IRS, after viral hepatitis was excluded.
true
true
true
true
true
6,828
6
DISCUSSION
1
18
[ "B18", "B18" ]
18,162,708
pmid-12031978|pmid-12031978
In this study, the RR for the abnormal ALT group was 1.87 (95% CI, 1.45-2.41).
[ "18", "18" ]
78
39,554
0
false
In this study, the RR for the abnormal ALT group was 1.87 (95% CI, 1.45-2.41).
[]
In this study, the RR for the abnormal ALT group was 1.87.
true
true
true
true
true
6,828
6
DISCUSSION
1
18
[ "B18", "B18" ]
18,162,708
pmid-12031978|pmid-12031978
Moreover, using logistic regression analysis after adjusting other risk factors, the RR for the abnormal ALT group was 1.70 (95% CI, 1.20-2.41).
[ "18", "18" ]
144
39,555
0
false
Moreover, using logistic regression analysis after adjusting other risk factors, the RR for the abnormal ALT group was 1.70 (95% CI, 1.20-2.41).
[]
Moreover, using logistic regression analysis after adjusting other risk factors, the RR for the abnormal ALT group was 1.70.
true
true
true
true
true
6,828
6
DISCUSSION
1
18
[ "B18", "B18" ]
18,162,708
pmid-12031978|pmid-12031978
These results suggest an association between liver disease and IRS, agreeing with the results of a prerious study (18).
[ "18", "18" ]
119
39,556
1
false
These results suggest an association between liver disease and IRS, agreeing with the results of a prerious study.
[ "18" ]
These results suggest an association between liver disease and IRS, agreeing with the results of a prerious study.
true
true
true
true
true
6,828
6
DISCUSSION
1
18
[ "B18", "B18" ]
18,162,708
pmid-12031978|pmid-12031978
Therefore, liver disease was correlated not only with problems of the liver itself but also with IRS, and this aspect points to the reason that nonalcoholic liver disease was selected as one of the components of IRS.
[ "18", "18" ]
216
39,557
0
false
Therefore, liver disease was correlated not only with problems of the liver itself but also with IRS, and this aspect points to the reason that nonalcoholic liver disease was selected as one of the components of IRS.
[]
Therefore, liver disease was correlated not only with problems of the liver itself but also with IRS, and this aspect points to the reason that nonalcoholic liver disease was selected as one of the components of IRS.
true
true
true
true
true
6,828
7
DISCUSSION
0
null
null
18,162,708
null
This study had some limitations.
null
32
39,558
0
false
null
null
This study had some limitations.
true
true
true
true
true
6,829
7
DISCUSSION
0
null
null
18,162,708
null
First, the workplace-based participants do not represent the general Korean population.
null
87
39,559
0
false
null
null
First, the workplace-based participants do not represent the general Korean population.
true
true
true
true
true
6,829
7
DISCUSSION
0
null
null
18,162,708
null
Second, it involved a short-term follow-up period, and therefore, a causal relationship related to the development of IRS could not be defined.
null
143
39,560
0
false
null
null
Second, it involved a short-term follow-up period, and therefore, a causal relationship related to the development of IRS could not be defined.
true
true
true
true
true
6,829
8
DISCUSSION
0
null
null
18,162,708
null
The annual incidence of IRS in Korean workers is high; therefore, early diagnosis and early treatment are necessary.
null
116
39,561
0
false
null
null
The annual incidence of IRS in Korean workers is high; therefore, early diagnosis and early treatment are necessary.
true
true
true
true
true
6,830
8
DISCUSSION
0
null
null
18,162,708
null
It is necessary to develop methods of prevention and therapeutic approach to manage the integrated risk factors.
null
112
39,562
0
false
null
null
It is necessary to develop methods of prevention and therapeutic approach to manage the integrated risk factors.
true
true
true
true
true
6,830
0
INTRODUCTION
1
1
[ "B1", "B2" ]
18,063,570
pmid-14681433|pmid-16219921
PlantGDB serves the plant research community by providing access to plant sequence data as well as a variety of sequence and genome analysis tools in a single online resource [(1,2); Table 1].
[ "1", "2" ]
192
39,563
0
false
PlantGDB serves the plant research community by providing access to plant sequence data as well as a variety of sequence and genome analysis tools in a single online resource.
[ "(1,2); Table 1" ]
PlantGDB serves the plant research community by providing access to plant sequence data as well as a variety of sequence and genome analysis tools in a single online resource.
true
true
true
true
true
6,831
0
INTRODUCTION
1
1
[ "B1", "B2" ]
18,063,570
pmid-14681433|pmid-16219921
This update outlines recent developments at PlantGDB that have expanded its usefulness as a tool for comparative genomics.
[ "1", "2" ]
122
39,564
0
false
This update outlines recent developments at PlantGDB that have expanded its usefulness as a tool for comparative genomics.
[]
This update outlines recent developments at PlantGDB that have expanded its usefulness as a tool for comparative genomics.
true
true
true
true
true
6,831
0
INTRODUCTION
1
1
[ "B1", "B2" ]
18,063,570
pmid-14681433|pmid-16219921
Key features include: expanded EST assemblies; new genome browsers for a larger number of species; overnight annotation of emerging genome sequences; and novel tools for sequence retrieval and analysis, including an innovative system for the creation and management of workflows that integrates database queries, linked ...
[ "1", "2" ]
350
39,565
0
false
Key features include: expanded EST assemblies; new genome browsers for a larger number of species; overnight annotation of emerging genome sequences; and novel tools for sequence retrieval and analysis, including an innovative system for the creation and management of workflows that integrates database queries, linked ...
[]
Key features include: expanded EST assemblies; new genome browsers for a larger number of species; overnight annotation of emerging genome sequences; and novel tools for sequence retrieval and analysis, including an innovative system for the creation and management of workflows that integrates database queries, linked ...
true
true
true
true
true
6,831
0
INTRODUCTION
1
1
[ "B1", "B2" ]
18,063,570
pmid-14681433|pmid-16219921
Table 1.Sequence resources and analytical tools available at PlantGDBIn this table, sequence resources are divided into four categories: Uploaded Sequence, Assembled Sequence, Genome Browsers, and Other Tools.
[ "1", "2" ]
209
39,566
0
false
Table 1.Sequence resources and analytical tools available at PlantGDBIn this table, sequence resources are divided into four categories: Uploaded Sequence, Assembled Sequence, Genome Browsers, and Other Tools.
[]
Table 1.Sequence resources and analytical tools available at PlantGDBIn this table, sequence resources are divided into four categories: Uploaded Sequence, Assembled Sequence, Genome Browsers, and Other Tools.
true
true
true
true
true
6,831
0
INTRODUCTION
1
1
[ "B1", "B2" ]
18,063,570
pmid-14681433|pmid-16219921
For each resource in column 1, the species available, source/version, current sequence count, update frequency, tool/services, download options, and alignment to genome are shown in adjacent cells.
[ "1", "2" ]
197
39,567
0
false
For each resource in column 1, the species available, source/version, current sequence count, update frequency, tool/services, download options, and alignment to genome are shown in adjacent cells.
[]
For each resource in column 1, the species available, source/version, current sequence count, update frequency, tool/services, download options, and alignment to genome are shown in adjacent cells.
true
true
true
true
true
6,831
0
INTRODUCTION
1
1
[ "B1", "B2" ]
18,063,570
pmid-14681433|pmid-16219921
Web links for both external and internal data/tool sources are indicated with superscript numbers and are listed at the end of the table under Web Resources.
[ "1", "2" ]
157
39,568
0
false
Web links for both external and internal data/tool sources are indicated with superscript numbers and are listed at the end of the table under Web Resources.
[]
Web links for both external and internal data/tool sources are indicated with superscript numbers and are listed at the end of the table under Web Resources.
true
true
true
true
true
6,831
0
INTRODUCTION
1
1
[ "B1", "B2" ]
18,063,570
pmid-14681433|pmid-16219921
Sequence counts displayed here are as of 30 October 2007.
[ "1", "2" ]
57
39,569
0
false
Sequence counts displayed here are as of 30 October 2007.
[]
Sequence counts displayed here are as of 30 October 2007.
true
true
true
true
true
6,831
1
INTRODUCTION
0
null
null
18,063,570
null
Sequence resources and analytical tools available at PlantGDB
null
61
39,570
0
false
null
null
Sequence resources and analytical tools available at PlantGDB
true
true
false
true
false
6,832
2
INTRODUCTION
0
null
null
18,063,570
null
In this table, sequence resources are divided into four categories: Uploaded Sequence, Assembled Sequence, Genome Browsers, and Other Tools.
null
140
39,571
0
false
null
null
In this table, sequence resources are divided into four categories: Uploaded Sequence, Assembled Sequence, Genome Browsers, and Other Tools.
true
true
true
true
true
6,833
2
INTRODUCTION
0
null
null
18,063,570
null
For each resource in column 1, the species available, source/version, current sequence count, update frequency, tool/services, download options, and alignment to genome are shown in adjacent cells.
null
197
39,572
0
false
null
null
For each resource in column 1, the species available, source/version, current sequence count, update frequency, tool/services, download options, and alignment to genome are shown in adjacent cells.
true
true
true
true
true
6,833
2
INTRODUCTION
0
null
null
18,063,570
null
Web links for both external and internal data/tool sources are indicated with superscript numbers and are listed at the end of the table under Web Resources.
null
157
39,573
0
false
null
null
Web links for both external and internal data/tool sources are indicated with superscript numbers and are listed at the end of the table under Web Resources.
true
true
true
true
true
6,833
2
INTRODUCTION
0
null
null
18,063,570
null
Sequence counts displayed here are as of 30 October 2007.
null
57
39,574
0
false
null
null
Sequence counts displayed here are as of 30 October 2007.
true
true
true
true
true
6,833
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B3", "B4", "B5", "B6", "B7" ]
17,427,647
NA|NA|pmid-10356155|pmid-10356155|pmid-9226216|pmid-1944469|pmid-1594625|pmid-10714367|pmid-3773215|pmid-10646121
McCune-Albright syndrome (MAS) is a rare disease that was originally defined by the triad of polyostotic fibrous dysplasia of the bone (FD), caf-au-lait skin pigmentation and precocious puberty1, 2).
[ "1", "2)", "3)", "3", "4)", "5", "6)", "7)" ]
199
39,575
0
false
McCune-Albright syndrome (MAS) is a rare disease that was originally defined by the triad of polyostotic fibrous dysplasia of the bone (FD), caf-au-lait skin pigmentation and precocious puberty1, 2).
[]
McCune-Albright syndrome (MAS) is a rare disease that was originally defined by the triad of polyostotic fibrous dysplasia of the bone (FD), caf-au-lait skin pigmentation and precocious puberty1, 2).
true
true
true
true
true
6,834
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B3", "B4", "B5", "B6", "B7" ]
17,427,647
NA|NA|pmid-10356155|pmid-10356155|pmid-9226216|pmid-1944469|pmid-1594625|pmid-10714367|pmid-3773215|pmid-10646121
A number of endocrine disorders such as hyperthyroidism, excess growth hormone (GH), Cushing syndrome3) and rickets/osteomalacia might be associated with MAS3, 4).
[ "1", "2)", "3)", "3", "4)", "5", "6)", "7)" ]
163
39,576
0
false
A number of endocrine disorders such as hyperthyroidism, excess growth hormone (GH), Cushing syndrome3) and rickets/osteomalacia might be associated with MAS3, 4).
[]
A number of endocrine disorders such as hyperthyroidism, excess growth hormone (GH), Cushing syndrome3) and rickets/osteomalacia might be associated with MAS3, 4).
true
true
true
true
true
6,834
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B3", "B4", "B5", "B6", "B7" ]
17,427,647
NA|NA|pmid-10356155|pmid-10356155|pmid-9226216|pmid-1944469|pmid-1594625|pmid-10714367|pmid-3773215|pmid-10646121
The disease results from post zygotic activating mutations of the cAMP regulating protein, GNAS1 gene product, and Gs5, 6).
[ "1", "2)", "3)", "3", "4)", "5", "6)", "7)" ]
123
39,577
0
false
The disease results from post zygotic activating mutations of the cAMP regulating protein, GNAS1 gene product, and Gs5, 6).
[]
The disease results from post zygotic activating mutations of the cAMP regulating protein, GNAS1 gene product, and Gs5, 6).
true
true
true
true
true
6,834
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B3", "B4", "B5", "B6", "B7" ]
17,427,647
NA|NA|pmid-10356155|pmid-10356155|pmid-9226216|pmid-1944469|pmid-1594625|pmid-10714367|pmid-3773215|pmid-10646121
Most Gs mutations are point mutations at the Arg201 position, with the majority being Arg201
[ "1", "2)", "3)", "3", "4)", "5", "6)", "7)" ]
92
39,578
0
false
Most Gs mutations are point mutations at the Arg201 position, with the majority being Arg201
[]
Most Gs mutations are point mutations at the Arg201 position, with the majority being Arg201
true
true
false
true
false
6,834
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B3", "B4", "B5", "B6", "B7" ]
17,427,647
NA|NA|pmid-10356155|pmid-10356155|pmid-9226216|pmid-1944469|pmid-1594625|pmid-10714367|pmid-3773215|pmid-10646121
His or Cys7).
[ "1", "2)", "3)", "3", "4)", "5", "6)", "7)" ]
13
39,579
0
false
His or Cys7).
[]
His or Cys7).
true
true
true
true
true
6,834
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B3", "B4", "B5", "B6", "B7" ]
17,427,647
NA|NA|pmid-10356155|pmid-10356155|pmid-9226216|pmid-1944469|pmid-1594625|pmid-10714367|pmid-3773215|pmid-10646121
Recently, weevaluated a 23-year-old man with typical MAS who had FD, skin pigmentation and multiple endocrinopathies including acromegaly, hyperprolactinemia and a thyroid nodule.
[ "1", "2)", "3)", "3", "4)", "5", "6)", "7)" ]
179
39,580
0
false
Recently, weevaluated a 23-year-old man with typical MAS who had FD, skin pigmentation and multiple endocrinopathies including acromegaly, hyperprolactinemia and a thyroid nodule.
[]
Recently, weevaluated a 23-year-old man with typical MAS who had FD, skin pigmentation and multiple endocrinopathies including acromegaly, hyperprolactinemia and a thyroid nodule.
true
true
true
true
true
6,834
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B3", "B4", "B5", "B6", "B7" ]
17,427,647
NA|NA|pmid-10356155|pmid-10356155|pmid-9226216|pmid-1944469|pmid-1594625|pmid-10714367|pmid-3773215|pmid-10646121
Genetic analysis confirmed a point mutation of the GNAS1 gene.
[ "1", "2)", "3)", "3", "4)", "5", "6)", "7)" ]
62
39,581
0
false
Genetic analysis confirmed a point mutation of the GNAS1 gene.
[]
Genetic analysis confirmed a point mutation of the GNAS1 gene.
true
true
true
true
true
6,834
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B3", "B4", "B5", "B6", "B7" ]
17,427,647
NA|NA|pmid-10356155|pmid-10356155|pmid-9226216|pmid-1944469|pmid-1594625|pmid-10714367|pmid-3773215|pmid-10646121
We report this case with a review of the relevant literature.
[ "1", "2)", "3)", "3", "4)", "5", "6)", "7)" ]
61
39,582
0
false
We report this case with a review of the relevant literature.
[]
We report this case with a review of the relevant literature.
true
true
true
true
true
6,834
0
DISCUSSION
1
8)
[ "B8", "B9" ]
17,427,647
NA|NA|pmid-10356155|pmid-10356155|pmid-9226216|pmid-1944469|pmid-1594625|pmid-10714367|pmid-3773215|pmid-10646121
Typical MAS is characterized by FD with at least one of the typical hyperfunctioning endocrinopathies along with caf-au-lait spots.
[ "8)", "9)" ]
131
39,583
0
false
Typical MAS is characterized by FD with at least one of the typical hyperfunctioning endocrinopathies along with caf-au-lait spots.
[]
Typical MAS is characterized by FD with at least one of the typical hyperfunctioning endocrinopathies along with caf-au-lait spots.
true
true
true
true
true
6,835
0
DISCUSSION
1
8)
[ "B8", "B9" ]
17,427,647
NA|NA|pmid-10356155|pmid-10356155|pmid-9226216|pmid-1944469|pmid-1594625|pmid-10714367|pmid-3773215|pmid-10646121
Unlike a typical case of MAS, patients with FD and more than two endocrine disorders without skin pigmentation or precocious puberty are defined as having atypical MAS8).
[ "8)", "9)" ]
170
39,584
0
false
Unlike a typical case of MAS, patients with FD and more than two endocrine disorders without skin pigmentation or precocious puberty are defined as having atypical MAS8).
[]
Unlike a typical case of MAS, patients with FD and more than two endocrine disorders without skin pigmentation or precocious puberty are defined as having atypical MAS8).
true
true
true
true
true
6,835
0
DISCUSSION
1
8)
[ "B8", "B9" ]
17,427,647
NA|NA|pmid-10356155|pmid-10356155|pmid-9226216|pmid-1944469|pmid-1594625|pmid-10714367|pmid-3773215|pmid-10646121
Although typical MAS is relatively rare, FD of the bone not associated with either skin pigmentation or endocrine disturbances is a frequent and usually serious skeletal disorder9).
[ "8)", "9)" ]
181
39,585
0
false
Although typical MAS is relatively rare, FD of the bone not associated with either skin pigmentation or endocrine disturbances is a frequent and usually serious skeletal disorder9).
[]
Although typical MAS is relatively rare, FD of the bone not associated with either skin pigmentation or endocrine disturbances is a frequent and usually serious skeletal disorder9).
true
true
true
true
true
6,835
1
DISCUSSION
1
10
[ "B10", "B12" ]
17,427,647
NA|NA
Only three cases of typical or atypical MAS have been reported in Korea10-12).
[ "10", "12)" ]
78
39,586
0
false
Only three cases of typical or atypical MAS have been reported in Korea10-12).
[]
Only three cases of typical or atypical MAS have been reported in Korea10-12).
true
true
true
true
true
6,836
1
DISCUSSION
1
10
[ "B10", "B12" ]
17,427,647
NA|NA
Bony fibrous dysplasia most commonly occurs in the proximal femur and at the base of the skull.
[ "10", "12)" ]
95
39,587
0
false
Bony fibrous dysplasia most commonly occurs in the proximal femur and at the base of the skull.
[]
Bony fibrous dysplasia most commonly occurs in the proximal femur and at the base of the skull.
true
true
true
true
true
6,836
1
DISCUSSION
1
10
[ "B10", "B12" ]
17,427,647
NA|NA
FD of the skeleton usually presents with a limp or pain but occasionally a pathologic fracture may be the presenting sign.
[ "10", "12)" ]
122
39,588
0
false
FD of the skeleton usually presents with a limp or pain but occasionally a pathologic fracture may be the presenting sign.
[]
FD of the skeleton usually presents with a limp or pain but occasionally a pathologic fracture may be the presenting sign.
true
true
true
true
true
6,836
1
DISCUSSION
1
10
[ "B10", "B12" ]
17,427,647
NA|NA
FD of the craniofacial bones can cause visual disturbances, proptosis, nasal obstructions, facial asymmetry or hearing abnormalities.
[ "10", "12)" ]
133
39,589
0
false
FD of the craniofacial bones can cause visual disturbances, proptosis, nasal obstructions, facial asymmetry or hearing abnormalities.
[]
FD of the craniofacial bones can cause visual disturbances, proptosis, nasal obstructions, facial asymmetry or hearing abnormalities.
true
true
true
true
true
6,836
2
DISCUSSION
1
3
[ "B3", "B4", "B13", "B14" ]
17,427,647
pmid-10356155|pmid-9226216|pmid-1624678|pmid-1424186
The endocrine disorders accompanying MAS are precocious puberty, pituitary adenomas secreting growth hormone and/or prolactin, Cushing syndrome, hypophosphatemic osteomalacia, thyroid abnormalities (hyperthyroidism and benign and malignant thyroid nodule) and hyperparathyroidism3, 4, 13).
[ "3", "4", "13)", "14)" ]
289
39,590
0
false
The endocrine disorders accompanying MAS are precocious puberty, pituitary adenomas secreting growth hormone and/or prolactin, Cushing syndrome, hypophosphatemic osteomalacia, thyroid abnormalities (hyperthyroidism and benign and malignant thyroid nodule) and hyperparathyroidism3, 4, 13).
[]
The endocrine disorders accompanying MAS are precocious puberty, pituitary adenomas secreting growth hormone and/or prolactin, Cushing syndrome, hypophosphatemic osteomalacia, thyroid abnormalities (hyperthyroidism and benign and malignant thyroid nodule) and hyperparathyroidism3, 4, 13).
true
true
true
true
true
6,837
2
DISCUSSION
1
3
[ "B3", "B4", "B13", "B14" ]
17,427,647
pmid-10356155|pmid-9226216|pmid-1624678|pmid-1424186
Growth hormone hypersecretion in MAS is common but differs from that observed in classic acromegaly in several aspects.
[ "3", "4", "13)", "14)" ]
119
39,591
0
false
Growth hormone hypersecretion in MAS is common but differs from that observed in classic acromegaly in several aspects.
[]
Growth hormone hypersecretion in MAS is common but differs from that observed in classic acromegaly in several aspects.
true
true
true
true
true
6,837
2
DISCUSSION
1
3
[ "B3", "B4", "B13", "B14" ]
17,427,647
pmid-10356155|pmid-9226216|pmid-1624678|pmid-1424186
Patients are generally young at onset and are diagnosed based on the observation of growth acceleration rather than from the facial dysmorphism, which is usually difficult to assess due to fibrous dysplasia14).
[ "3", "4", "13)", "14)" ]
210
39,592
0
false
Patients are generally young at onset and are diagnosed based on the observation of growth acceleration rather than from the facial dysmorphism, which is usually difficult to assess due to fibrous dysplasia14).
[]
Patients are generally young at onset and are diagnosed based on the observation of growth acceleration rather than from the facial dysmorphism, which is usually difficult to assess due to fibrous dysplasia14).
true
true
true
true
true
6,837
2
DISCUSSION
1
3
[ "B3", "B4", "B13", "B14" ]
17,427,647
pmid-10356155|pmid-9226216|pmid-1624678|pmid-1424186
MAS with a GH excess has a distinct clinical phenotype that is characterized by the TRH responsiveness, prolactin co-secretion, small or absent pituitary tumors, a consistent but inadequate response to a treatment with cabergoline, and an intermediate response to sandostatin LAR.
[ "3", "4", "13)", "14)" ]
280
39,593
0
false
MAS with a GH excess has a distinct clinical phenotype that is characterized by the TRH responsiveness, prolactin co-secretion, small or absent pituitary tumors, a consistent but inadequate response to a treatment with cabergoline, and an intermediate response to sandostatin LAR.
[]
MAS with a GH excess has a distinct clinical phenotype that is characterized by the TRH responsiveness, prolactin co-secretion, small or absent pituitary tumors, a consistent but inadequate response to a treatment with cabergoline, and an intermediate response to sandostatin LAR.
true
true
true
true
true
6,837
2
DISCUSSION
1
3
[ "B3", "B4", "B13", "B14" ]
17,427,647
pmid-10356155|pmid-9226216|pmid-1624678|pmid-1424186
Vision and hearing deficits are more common in MAS with an excess of GH than in those without an excess.
[ "3", "4", "13)", "14)" ]
104
39,594
0
false
Vision and hearing deficits are more common in MAS with an excess of GH than in those without an excess.
[]
Vision and hearing deficits are more common in MAS with an excess of GH than in those without an excess.
true
true
true
true
true
6,837
2
DISCUSSION
1
3
[ "B3", "B4", "B13", "B14" ]
17,427,647
pmid-10356155|pmid-9226216|pmid-1624678|pmid-1424186
Patients with precocious puberty and an excess of GH have achieved a normal adult height despite a history of early epiphyseal fusion.
[ "3", "4", "13)", "14)" ]
134
39,595
0
false
Patients with precocious puberty and an excess of GH have achieved a normal adult height despite a history of early epiphyseal fusion.
[]
Patients with precocious puberty and an excess of GH have achieved a normal adult height despite a history of early epiphyseal fusion.
true
true
true
true
true
6,837
3
DISCUSSION
1
9)
[ "B9", "B5", "B15", "B14", "B16", "B17", "B18", "B19", "B4" ]
17,427,647
pmid-10646121|pmid-1944469|pmid-10036690|pmid-1424186|pmid-7714111|pmid-11397839|NA|pmid-2754454|pmid-9226216
MAS syndrome is the result of an activating mutation of the alpha subunit of the Gs protein (GNAS1 gene), which causes the constitutive activation of adenylate cyclase.
[ "9)", "5)", "15)", "14", "16", "17)", "18", "19)", "4)" ]
168
39,596
0
false
MAS syndrome is the result of an activating mutation of the alpha subunit of the Gs protein (GNAS1 gene), which causes the constitutive activation of adenylate cyclase.
[]
MAS syndrome is the result of an activating mutation of the alpha subunit of the Gs protein (GNAS1 gene), which causes the constitutive activation of adenylate cyclase.
true
true
true
true
true
6,838
3
DISCUSSION
1
9)
[ "B9", "B5", "B15", "B14", "B16", "B17", "B18", "B19", "B4" ]
17,427,647
pmid-10646121|pmid-1944469|pmid-10036690|pmid-1424186|pmid-7714111|pmid-11397839|NA|pmid-2754454|pmid-9226216
In all published cases of MAS, mutations of GS at the R201 position have been identified9).
[ "9)", "5)", "15)", "14", "16", "17)", "18", "19)", "4)" ]
91
39,597
0
false
In all published cases of MAS, mutations of GS at the R201 position have been identified9).
[]
In all published cases of MAS, mutations of GS at the R201 position have been identified9).
true
true
true
true
true
6,838
3
DISCUSSION
1
9)
[ "B9", "B5", "B15", "B14", "B16", "B17", "B18", "B19", "B4" ]
17,427,647
pmid-10646121|pmid-1944469|pmid-10036690|pmid-1424186|pmid-7714111|pmid-11397839|NA|pmid-2754454|pmid-9226216
The unproven but accepted explanation for the lack of vertical transmission, along with the observation that the skin and bone lesions tend to lateralize, is that the disease results from postzygotic mutations.
[ "9)", "5)", "15)", "14", "16", "17)", "18", "19)", "4)" ]
210
39,598
0
false
The unproven but accepted explanation for the lack of vertical transmission, along with the observation that the skin and bone lesions tend to lateralize, is that the disease results from postzygotic mutations.
[]
The unproven but accepted explanation for the lack of vertical transmission, along with the observation that the skin and bone lesions tend to lateralize, is that the disease results from postzygotic mutations.
true
true
true
true
true
6,838
3
DISCUSSION
1
9)
[ "B9", "B5", "B15", "B14", "B16", "B17", "B18", "B19", "B4" ]
17,427,647
pmid-10646121|pmid-1944469|pmid-10036690|pmid-1424186|pmid-7714111|pmid-11397839|NA|pmid-2754454|pmid-9226216
Hence, the patients are referred to as somatic mosaics.
[ "9)", "5)", "15)", "14", "16", "17)", "18", "19)", "4)" ]
55
39,599
0
false
Hence, the patients are referred to as somatic mosaics.
[]
Hence, the patients are referred to as somatic mosaics.
true
true
true
true
true
6,838
3
DISCUSSION
1
9)
[ "B9", "B5", "B15", "B14", "B16", "B17", "B18", "B19", "B4" ]
17,427,647
pmid-10646121|pmid-1944469|pmid-10036690|pmid-1424186|pmid-7714111|pmid-11397839|NA|pmid-2754454|pmid-9226216
The mosaicism could explain the varied clinical picture of those with this syndrome5).
[ "9)", "5)", "15)", "14", "16", "17)", "18", "19)", "4)" ]
86
39,600
0
false
The mosaicism could explain the varied clinical picture of those with this syndrome5).
[]
The mosaicism could explain the varied clinical picture of those with this syndrome5).
true
true
true
true
true
6,838
3
DISCUSSION
1
9)
[ "B9", "B5", "B15", "B14", "B16", "B17", "B18", "B19", "B4" ]
17,427,647
pmid-10646121|pmid-1944469|pmid-10036690|pmid-1424186|pmid-7714111|pmid-11397839|NA|pmid-2754454|pmid-9226216
The percentage of cells with the GNAS1 mutation out of a total number of cells in each tissue might be very low due to the mosaicism.
[ "9)", "5)", "15)", "14", "16", "17)", "18", "19)", "4)" ]
133
39,601
0
false
The percentage of cells with the GNAS1 mutation out of a total number of cells in each tissue might be very low due to the mosaicism.
[]
The percentage of cells with the GNAS1 mutation out of a total number of cells in each tissue might be very low due to the mosaicism.
true
true
true
true
true
6,838
3
DISCUSSION
1
9)
[ "B9", "B5", "B15", "B14", "B16", "B17", "B18", "B19", "B4" ]
17,427,647
pmid-10646121|pmid-1944469|pmid-10036690|pmid-1424186|pmid-7714111|pmid-11397839|NA|pmid-2754454|pmid-9226216
This explains why GS mutations at the R201 position are detected only in the thyroid tissue by direct base sequencing, as in our case.
[ "9)", "5)", "15)", "14", "16", "17)", "18", "19)", "4)" ]
134
39,602
0
false
This explains why GS mutations at the R201 position are detected only in the thyroid tissue by direct base sequencing, as in our case.
[]
This explains why GS mutations at the R201 position are detected only in the thyroid tissue by direct base sequencing, as in our case.
true
true
true
true
true
6,838
3
DISCUSSION
1
9)
[ "B9", "B5", "B15", "B14", "B16", "B17", "B18", "B19", "B4" ]
17,427,647
pmid-10646121|pmid-1944469|pmid-10036690|pmid-1424186|pmid-7714111|pmid-11397839|NA|pmid-2754454|pmid-9226216
However, the detection of a mutation in all samples was obtained after using the mutation allele specific amplification method.
[ "9)", "5)", "15)", "14", "16", "17)", "18", "19)", "4)" ]
127
39,603
0
false
However, the detection of a mutation in all samples was obtained after using the mutation allele specific amplification method.
[]
However, the detection of a mutation in all samples was obtained after using the mutation allele specific amplification method.
true
true
true
true
true
6,838
3
DISCUSSION
1
9)
[ "B9", "B5", "B15", "B14", "B16", "B17", "B18", "B19", "B4" ]
17,427,647
pmid-10646121|pmid-1944469|pmid-10036690|pmid-1424186|pmid-7714111|pmid-11397839|NA|pmid-2754454|pmid-9226216
FD presents a treatment dilemma because there is no proven medical therapy.
[ "9)", "5)", "15)", "14", "16", "17)", "18", "19)", "4)" ]
75
39,604
0
false
FD presents a treatment dilemma because there is no proven medical therapy.
[]
FD presents a treatment dilemma because there is no proven medical therapy.
true
true
true
true
true
6,838
3
DISCUSSION
1
9)
[ "B9", "B5", "B15", "B14", "B16", "B17", "B18", "B19", "B4" ]
17,427,647
pmid-10646121|pmid-1944469|pmid-10036690|pmid-1424186|pmid-7714111|pmid-11397839|NA|pmid-2754454|pmid-9226216
Bisphosphates have been shown to reduce the incidence of fractures and reduce the intensity of bone pain.
[ "9)", "5)", "15)", "14", "16", "17)", "18", "19)", "4)" ]
105
39,605
0
false
Bisphosphates have been shown to reduce the incidence of fractures and reduce the intensity of bone pain.
[]
Bisphosphates have been shown to reduce the incidence of fractures and reduce the intensity of bone pain.
true
true
true
true
true
6,838
3
DISCUSSION
1
9)
[ "B9", "B5", "B15", "B14", "B16", "B17", "B18", "B19", "B4" ]
17,427,647
pmid-10646121|pmid-1944469|pmid-10036690|pmid-1424186|pmid-7714111|pmid-11397839|NA|pmid-2754454|pmid-9226216
However, the only cure for FD is a surgical resection, which is difficult in the skull and facial regions.
[ "9)", "5)", "15)", "14", "16", "17)", "18", "19)", "4)" ]
106
39,606
0
false
However, the only cure for FD is a surgical resection, which is difficult in the skull and facial regions.
[]
However, the only cure for FD is a surgical resection, which is difficult in the skull and facial regions.
true
true
true
true
true
6,838
3
DISCUSSION
1
9)
[ "B9", "B5", "B15", "B14", "B16", "B17", "B18", "B19", "B4" ]
17,427,647
pmid-10646121|pmid-1944469|pmid-10036690|pmid-1424186|pmid-7714111|pmid-11397839|NA|pmid-2754454|pmid-9226216
Surgery is recommended when there is a functional cranial nerve deficit in order to prevent or limit the permanent loss of function15).
[ "9)", "5)", "15)", "14", "16", "17)", "18", "19)", "4)" ]
135
39,607
0
false
Surgery is recommended when there is a functional cranial nerve deficit in order to prevent or limit the permanent loss of function15).
[]
Surgery is recommended when there is a functional cranial nerve deficit in order to prevent or limit the permanent loss of function15).
true
true
true
true
true
6,838
3
DISCUSSION
1
9)
[ "B9", "B5", "B15", "B14", "B16", "B17", "B18", "B19", "B4" ]
17,427,647
pmid-10646121|pmid-1944469|pmid-10036690|pmid-1424186|pmid-7714111|pmid-11397839|NA|pmid-2754454|pmid-9226216
Medical treatment using a somatostatin or dopamine agonist is often the only option in patients with MAS and an excess of GH because transsphenoidal surgery is not possible due to the massive thickening of the skull base with FD14, 16, 17).
[ "9)", "5)", "15)", "14", "16", "17)", "18", "19)", "4)" ]
240
39,608
0
false
Medical treatment using a somatostatin or dopamine agonist is often the only option in patients with MAS and an excess of GH because transsphenoidal surgery is not possible due to the massive thickening of the skull base with FD14, 16, 17).
[]
Medical treatment using a somatostatin or dopamine agonist is often the only option in patients with MAS and an excess of GH because transsphenoidal surgery is not possible due to the massive thickening of the skull base with FD14, 16, 17).
true
true
true
true
true
6,838
3
DISCUSSION
1
9)
[ "B9", "B5", "B15", "B14", "B16", "B17", "B18", "B19", "B4" ]
17,427,647
pmid-10646121|pmid-1944469|pmid-10036690|pmid-1424186|pmid-7714111|pmid-11397839|NA|pmid-2754454|pmid-9226216
Radiation therapy is not considered to be an option because it is believed to predispose FD to a sarcomatous transformation18, 19).
[ "9)", "5)", "15)", "14", "16", "17)", "18", "19)", "4)" ]
131
39,609
0
false
Radiation therapy is not considered to be an option because it is believed to predispose FD to a sarcomatous transformation18, 19).
[]
Radiation therapy is not considered to be an option because it is believed to predispose FD to a sarcomatous transformation18, 19).
true
true
true
true
true
6,838
3
DISCUSSION
1
9)
[ "B9", "B5", "B15", "B14", "B16", "B17", "B18", "B19", "B4" ]
17,427,647
pmid-10646121|pmid-1944469|pmid-10036690|pmid-1424186|pmid-7714111|pmid-11397839|NA|pmid-2754454|pmid-9226216
Hyperthyroidism in a MAS setting is treated with the same medication options used for treating hyperthyroidism4).
[ "9)", "5)", "15)", "14", "16", "17)", "18", "19)", "4)" ]
113
39,610
0
false
Hyperthyroidism in a MAS setting is treated with the same medication options used for treating hyperthyroidism4).
[]
Hyperthyroidism in a MAS setting is treated with the same medication options used for treating hyperthyroidism4).
true
true
true
true
true
6,838
4
DISCUSSION
0
null
null
17,427,647
null
Wepresent a case of Typical MAS with FD, skin pigmentation, acromegaly, hyperprolactinemia, and a thyroid nodule in a 23-year-old man.
null
134
39,611
0
false
null
null
Wepresent a case of Typical MAS with FD, skin pigmentation, acromegaly, hyperprolactinemia, and a thyroid nodule in a 23-year-old man.
true
true
true
true
true
6,839
0
INTRODUCTION
1
1
[ "B1", "B2", "B3" ]
21,076,576
pmid-18487478|pmid-15793191|pmid-19410252
Recent works suggest a certain cutoff of elevated 1-hour plasma glucose during oral glucose tolerance test (OGTT) is a strong predictor of future risk for type 2 diabetes, suggesting the role of 1-hour post-challenge glucose in the alteration of glucose metabolism status as well as 2-hour post-challenge glucose [1,2].
[ "1", "2", "3" ]
319
39,612
0
false
Recent works suggest a certain cutoff of elevated 1-hour plasma glucose during oral glucose tolerance test (OGTT) is a strong predictor of future risk for type 2 diabetes, suggesting the role of 1-hour post-challenge glucose in the alteration of glucose metabolism status as well as 2-hour post-challenge glucose.
[ "1,2" ]
Recent works suggest a certain cutoff of elevated 1-hour plasma glucose during oral glucose tolerance test (OGTT) is a strong predictor of future risk for type 2 diabetes, suggesting the role of 1-hour post-challenge glucose in the alteration of glucose metabolism status as well as 2-hour post-challenge glucose.
true
true
true
true
true
6,840
0
INTRODUCTION
1
3
[ "B1", "B2", "B3" ]
21,076,576
pmid-18487478|pmid-15793191|pmid-19410252
A very recent work reported that elevated 1-hour post-load plasma glucose level identifies subjects with normal glucose tolerance but subclinical atherosclerosis measured by carotid intima-media thickness [3].
[ "1", "2", "3" ]
209
39,613
1
false
A very recent work reported that elevated 1-hour post-load plasma glucose level identifies subjects with normal glucose tolerance but subclinical atherosclerosis measured by carotid intima-media thickness.
[ "3" ]
A very recent work reported that elevated 1-hour post-load plasma glucose level identifies subjects with normal glucose tolerance but subclinical atherosclerosis measured by carotid intima-media thickness.
true
true
true
true
true
6,840
0
INTRODUCTION
1
1
[ "B1", "B2", "B3" ]
21,076,576
pmid-18487478|pmid-15793191|pmid-19410252
These results imply the importance of acute post-challenge glucose excursions in the development of atherosclerosis.
[ "1", "2", "3" ]
116
39,614
0
false
These results imply the importance of acute post-challenge glucose excursions in the development of atherosclerosis.
[]
These results imply the importance of acute post-challenge glucose excursions in the development of atherosclerosis.
true
true
true
true
true
6,840
1
INTRODUCTION
1
4
[ "B4", "B5", "B6", "B7", "B8", "B9" ]
21,076,576
pmid-17581229|pmid-17611734|pmid-14567500|pmid-16401315|pmid-17785928|pmid-18607561|pmid-12615661|pmid-18607561|pmid-12615661|pmid-14662706|pmid-14698999|pmid-12379578|pmid-14698999|pmid-12560165|pmid-12695300|pmid-12379578
Arterial stiffness is an independent predictor of cardiovascular morbidity and mortality [4,5].
[ "4", "5", "6", "7", "8", "9" ]
95
39,615
0
false
Arterial stiffness is an independent predictor of cardiovascular morbidity and mortality.
[ "4,5" ]
Arterial stiffness is an independent predictor of cardiovascular morbidity and mortality.
true
true
true
true
true
6,841