paragraph_index int64 | sec string | p_has_citation int64 | cites string | citeids list | pmid int64 | cited_id string | sentences string | all_sent_cites list | sent_len int64 | sentence_batch_index int64 | sent_has_citation float64 | qc_fail bool | cited_sentence string | cites_in_sentence list | cln_sentence string | is_cap bool | is_alpha bool | ends_wp bool | cit_qc bool | lgtm bool | __index_level_0__ int64 |
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1 | INTRODUCTION | 1 | Hemara-Wahanui et al., 2005 | [
"bib12",
"bib15",
"bib13",
"bib24",
"bib28",
"bib31"
] | 19,687,230 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | In continuation of these studies, we substituted residues in the lower third of segment IIS6 by flexible glycines. | [
"Hemara-Wahanui et al., 2005",
"Hohaus et al., 2005",
"Hering et al., 2008",
"Stary et al., 2008",
"Yifrach and MacKinnon, 2002",
"Zhao et al., 2004"
] | 114 | 39,716 | 0 | false | In continuation of these studies, we substituted residues in the lower third of segment IIS6 by flexible glycines. | [] | In continuation of these studies, we substituted residues in the lower third of segment IIS6 by flexible glycines. | true | true | true | true | true | 6,859 |
1 | INTRODUCTION | 1 | Hemara-Wahanui et al., 2005 | [
"bib12",
"bib15",
"bib13",
"bib24",
"bib28",
"bib31"
] | 19,687,230 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | In line with our previous data, these mutations induced remarkable shifts of the activation curve to hyperpolarized voltages and characteristic slowing of the activation and deactivation kinetics. | [
"Hemara-Wahanui et al., 2005",
"Hohaus et al., 2005",
"Hering et al., 2008",
"Stary et al., 2008",
"Yifrach and MacKinnon, 2002",
"Zhao et al., 2004"
] | 196 | 39,717 | 0 | false | In line with our previous data, these mutations induced remarkable shifts of the activation curve to hyperpolarized voltages and characteristic slowing of the activation and deactivation kinetics. | [] | In line with our previous data, these mutations induced remarkable shifts of the activation curve to hyperpolarized voltages and characteristic slowing of the activation and deactivation kinetics. | true | true | true | true | true | 6,859 |
1 | INTRODUCTION | 1 | Hemara-Wahanui et al., 2005 | [
"bib12",
"bib15",
"bib13",
"bib24",
"bib28",
"bib31"
] | 19,687,230 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Shifts of the activation curve can be interpreted as destabilization of the closed state and/or as stabilization of the open-channel conformation (Yifrach and MacKinnon, 2002; Zhao et al., 2004). | [
"Hemara-Wahanui et al., 2005",
"Hohaus et al., 2005",
"Hering et al., 2008",
"Stary et al., 2008",
"Yifrach and MacKinnon, 2002",
"Zhao et al., 2004"
] | 195 | 39,718 | 0 | false | Shifts of the activation curve can be interpreted as destabilization of the closed state and/or as stabilization of the open-channel conformation. | [
"Yifrach and MacKinnon, 2002; Zhao et al., 2004"
] | Shifts of the activation curve can be interpreted as destabilization of the closed state and/or as stabilization of the open-channel conformation. | true | true | true | true | true | 6,859 |
2 | INTRODUCTION | 1 | Yifrach and MacKinnon, 2002 | [
"bib28",
"bib7"
] | 19,687,230 | NA|NA|NA|NA | To distinguish between these possibilities, we analyzed changes in steady-state activation and current kinetics in terms of a four-state model where activation and deactivation may occur predominantly via different pathways (see Fig. | [
"Yifrach and MacKinnon, 2002",
"Engl et al., 1996"
] | 233 | 39,719 | 0 | false | To distinguish between these possibilities, we analyzed changes in steady-state activation and current kinetics in terms of a four-state model where activation and deactivation may occur predominantly via different pathways (see Fig. | [] | To distinguish between these possibilities, we analyzed changes in steady-state activation and current kinetics in terms of a four-state model where activation and deactivation may occur predominantly via different pathways (see Fig. | true | true | true | true | true | 6,860 |
2 | INTRODUCTION | 1 | Yifrach and MacKinnon, 2002 | [
"bib28",
"bib7"
] | 19,687,230 | NA|NA|NA|NA | Under the assumption that pore mutations in IIS6 do not affect the activating transition of the voltage-sensing machinery (x(V), y(V)) (Yifrach and MacKinnon, 2002), rate constants for 16 CaV1.2 constructs were estimated by means of an inverse problem approach (see Engl et al., 1996). | [
"Yifrach and MacKinnon, 2002",
"Engl et al., 1996"
] | 285 | 39,720 | 1 | false | Under the assumption that pore mutations in IIS6 do not affect the activating transition of the voltage-sensing machinery (x(V), y(V)), rate constants for 16 CaV1.2 constructs were estimated by means of an inverse problem approach. | [
"Yifrach and MacKinnon, 2002",
"see Engl et al., 1996"
] | Under the assumption that pore mutations in IIS6 do not affect the activating transition of the voltage-sensing machinery (x(V), y(V)), rate constants for 16 CaV1.2 constructs were estimated by means of an inverse problem approach. | true | true | true | true | true | 6,860 |
2 | INTRODUCTION | 1 | Yifrach and MacKinnon, 2002 | [
"bib28",
"bib7"
] | 19,687,230 | NA|NA|NA|NA | Satisfactory fits for 15 out of 16 channel constructs were achieved assuming a single pair of x(V) and y(V). | [
"Yifrach and MacKinnon, 2002",
"Engl et al., 1996"
] | 108 | 39,721 | 0 | false | Satisfactory fits for 15 out of 16 channel constructs were achieved assuming a single pair of x(V) and y(V). | [] | Satisfactory fits for 15 out of 16 channel constructs were achieved assuming a single pair of x(V) and y(V). | true | true | true | true | true | 6,860 |
2 | INTRODUCTION | 1 | Yifrach and MacKinnon, 2002 | [
"bib28",
"bib7"
] | 19,687,230 | NA|NA|NA|NA | These results suggest that most of the analyzed structural changes in IIS6 do not significantly affect the voltage-sensing domain. | [
"Yifrach and MacKinnon, 2002",
"Engl et al., 1996"
] | 130 | 39,722 | 0 | false | These results suggest that most of the analyzed structural changes in IIS6 do not significantly affect the voltage-sensing domain. | [] | These results suggest that most of the analyzed structural changes in IIS6 do not significantly affect the voltage-sensing domain. | true | true | true | true | true | 6,860 |
2 | INTRODUCTION | 1 | Yifrach and MacKinnon, 2002 | [
"bib28",
"bib7"
] | 19,687,230 | NA|NA|NA|NA | Fitting the kinetics of mutant A780P required individual adjustment of x(V) and y(V), suggesting that stiff helix kinking in this position may affect voltage sensor movements. | [
"Yifrach and MacKinnon, 2002",
"Engl et al., 1996"
] | 175 | 39,723 | 0 | false | Fitting the kinetics of mutant A780P required individual adjustment of x(V) and y(V), suggesting that stiff helix kinking in this position may affect voltage sensor movements. | [] | Fitting the kinetics of mutant A780P required individual adjustment of x(V) and y(V), suggesting that stiff helix kinking in this position may affect voltage sensor movements. | true | true | true | true | true | 6,860 |
3 | INTRODUCTION | 0 | null | null | 19,687,230 | null | Schematic representation of CaV1.2 state transitions during activation. | null | 71 | 39,724 | 0 | false | null | null | Schematic representation of CaV1.2 state transitions during activation. | true | true | true | true | true | 6,861 |
3 | INTRODUCTION | 0 | null | null | 19,687,230 | null | Activation gating assumed to be determined by two functionally separate processes: a voltage-sensing mechanism (++) and the conducting pore. | null | 140 | 39,725 | 0 | false | null | null | Activation gating assumed to be determined by two functionally separate processes: a voltage-sensing mechanism (++) and the conducting pore. | true | true | true | true | true | 6,861 |
3 | INTRODUCTION | 0 | null | null | 19,687,230 | null | Each functional unit can dwell in two states: the voltage sensor in the resting (down) and activated (up) states, and the pore in the open or closed states. | null | 156 | 39,726 | 0 | false | null | null | Each functional unit can dwell in two states: the voltage sensor in the resting (down) and activated (up) states, and the pore in the open or closed states. | true | true | true | true | true | 6,861 |
3 | INTRODUCTION | 0 | null | null | 19,687,230 | null | The entire molecule therefore dwells in 2 × 2 = 4 states: R, pore is closed and voltage-sensing mechanism locks the pore; A, voltage-sensing mechanism is activated and releases the pore, which, however, remains closed; O, the pore is open; D, the deactivated voltage-sensing mechanism is in the down position while the p... | null | 338 | 39,727 | 0 | false | null | null | The entire molecule therefore dwells in 2 × 2 = 4 states: R, pore is closed and voltage-sensing mechanism locks the pore; A, voltage-sensing mechanism is activated and releases the pore, which, however, remains closed; O, the pore is open; D, the deactivated voltage-sensing mechanism is in the down position while the p... | true | true | true | true | true | 6,861 |
3 | INTRODUCTION | 0 | null | null | 19,687,230 | null | The activation pathway is marked by red and the deactivation pathway by blue arrows. | null | 84 | 39,728 | 0 | false | null | null | The activation pathway is marked by red and the deactivation pathway by blue arrows. | true | true | true | true | true | 6,861 |
3 | INTRODUCTION | 0 | null | null | 19,687,230 | null | Rate constants of the pore opening and closure (α, β, γ, and δ) are assumed to be independent of the voltage. | null | 109 | 39,729 | 0 | false | null | null | Rate constants of the pore opening and closure (α, β, γ, and δ) are assumed to be independent of the voltage. | true | true | true | true | true | 6,861 |
3 | INTRODUCTION | 0 | null | null | 19,687,230 | null | Rate constants of voltage-sensing mechanism (x, y, u, and w) are voltage dependent. | null | 83 | 39,730 | 0 | false | null | null | Rate constants of voltage-sensing mechanism (x, y, u, and w) are voltage dependent. | true | true | true | true | true | 6,861 |
0 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15",
"bib22",
"bib13"
] | 19,687,230 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | We have previously shown that amino acid substitutions in the lower third of segment IIS6 of CaV1.2, and in particular the substitution of I781 by residues of different hydrophobicity, size, and polarity, shift the voltage dependence of activation toward more negative potentials (Hohaus et al., 2005; Raybaud et al., 20... | [
"Hohaus et al., 2005",
"Raybaud et al., 2006",
"Hering et al., 2008"
] | 345 | 39,731 | 0 | false | We have previously shown that amino acid substitutions in the lower third of segment IIS6 of CaV1.2, and in particular the substitution of I781 by residues of different hydrophobicity, size, and polarity, shift the voltage dependence of activation toward more negative potentials. | [
"Hohaus et al., 2005; Raybaud et al., 2006; Hering et al., 2008"
] | We have previously shown that amino acid substitutions in the lower third of segment IIS6 of CaV1.2, and in particular the substitution of I781 by residues of different hydrophobicity, size, and polarity, shift the voltage dependence of activation toward more negative potentials. | true | true | true | true | true | 6,862 |
1 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15",
"bib19",
"bib15",
"bib19"
] | 19,687,230 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Here, we extended this analysis by introducing glycine mutations to evaluate the role of helix flexibility. | [
"Hohaus et al., 2005",
"Kudrnac et al., 2009",
"Hohaus et al., 2005",
"Kudrnac et al., 2009"
] | 107 | 39,732 | 0 | false | Here, we extended this analysis by introducing glycine mutations to evaluate the role of helix flexibility. | [] | Here, we extended this analysis by introducing glycine mutations to evaluate the role of helix flexibility. | true | true | true | true | true | 6,863 |
1 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15",
"bib19",
"bib15",
"bib19"
] | 19,687,230 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Substitution of I781 by glycine induced slow activation and deactivation kinetics and a substantial shift of the activation curve (ΔVact = −30 mV). | [
"Hohaus et al., 2005",
"Kudrnac et al., 2009",
"Hohaus et al., 2005",
"Kudrnac et al., 2009"
] | 147 | 39,733 | 0 | false | Substitution of I781 by glycine induced slow activation and deactivation kinetics and a substantial shift of the activation curve (ΔVact = −30 mV). | [] | Substitution of I781 by glycine induced slow activation and deactivation kinetics and a substantial shift of the activation curve. | true | true | true | true | true | 6,863 |
1 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15",
"bib19",
"bib15",
"bib19"
] | 19,687,230 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Other glycin mutations affected kinetics to different extents and induced, compared with the strong gating perturbations induced by I781P/T, less pronounced shifts of the activation curves (I781P > I781G > I781T > | [
"Hohaus et al., 2005",
"Kudrnac et al., 2009",
"Hohaus et al., 2005",
"Kudrnac et al., 2009"
] | 213 | 39,734 | 0 | false | Other glycin mutations affected kinetics to different extents and induced, compared with the strong gating perturbations induced by I781P/T, less pronounced shifts of the activation curves (I781P > I781G > I781T > | [] | Other glycin mutations affected kinetics to different extents and induced, compared with the strong gating perturbations induced by I781P/T, less pronounced shifts of the activation curves (I781P > I781G > I781T > | true | true | false | true | false | 6,863 |
1 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15",
"bib19",
"bib15",
"bib19"
] | 19,687,230 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | A782G > A780G > D784G; Table I and Figs. | [
"Hohaus et al., 2005",
"Kudrnac et al., 2009",
"Hohaus et al., 2005",
"Kudrnac et al., 2009"
] | 40 | 39,735 | 0 | false | A782G > A780G > D784G; Table I and Figs. | [] | A782G > A780G > D784G; Table I and Figs. | true | true | true | true | true | 6,863 |
1 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15",
"bib19",
"bib15",
"bib19"
] | 19,687,230 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | 2 and 3; compare with Fig. | [
"Hohaus et al., 2005",
"Kudrnac et al., 2009",
"Hohaus et al., 2005",
"Kudrnac et al., 2009"
] | 26 | 39,736 | 0 | false | 2 and 3; compare with Fig. | [] | 2 and 3; compare with Fig. | false | false | true | true | false | 6,863 |
1 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15",
"bib19",
"bib15",
"bib19"
] | 19,687,230 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Mutation I781G thus confirmed the previously established particular gating-sensitive position I781 (Hohaus et al., 2005; see also Kudrnac et al., 2009). | [
"Hohaus et al., 2005",
"Kudrnac et al., 2009",
"Hohaus et al., 2005",
"Kudrnac et al., 2009"
] | 152 | 39,737 | 0 | false | Mutation I781G thus confirmed the previously established particular gating-sensitive position I781. | [
"Hohaus et al., 2005; see also Kudrnac et al., 2009"
] | Mutation I781G thus confirmed the previously established particular gating-sensitive position I781. | true | true | true | true | true | 6,863 |
1 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15",
"bib19",
"bib15",
"bib19"
] | 19,687,230 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | In general, glycine substitutions and other IIS6 mutations in CaV1.2 induced either negligible changes (e.g., G770P; Hohaus et al., 2005) or substantial shifts in channel gating accompanied by a deceleration of activation kinetics. | [
"Hohaus et al., 2005",
"Kudrnac et al., 2009",
"Hohaus et al., 2005",
"Kudrnac et al., 2009"
] | 231 | 39,738 | 0 | false | In general, glycine substitutions and other IIS6 mutations in CaV1.2 induced either negligible changes or substantial shifts in channel gating accompanied by a deceleration of activation kinetics. | [
"e.g., G770P; Hohaus et al., 2005"
] | In general, glycine substitutions and other IIS6 mutations in CaV1.2 induced either negligible changes or substantial shifts in channel gating accompanied by a deceleration of activation kinetics. | true | true | true | true | true | 6,863 |
1 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15",
"bib19",
"bib15",
"bib19"
] | 19,687,230 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Collectively, these and previous data revealed a link between deceleration of current kinetics and the gradual leftward shift of the activation curve (Fig. | [
"Hohaus et al., 2005",
"Kudrnac et al., 2009",
"Hohaus et al., 2005",
"Kudrnac et al., 2009"
] | 155 | 39,739 | 0 | false | Collectively, these and previous data revealed a link between deceleration of current kinetics and the gradual leftward shift of the activation curve (Fig. | [] | Collectively, these and previous data revealed a link between deceleration of current kinetics and the gradual leftward shift of the activation curve (Fig. | true | true | true | true | true | 6,863 |
1 | DISCUSSION | 1 | Kudrnac et al., 2009 | [
"bib15",
"bib19",
"bib15",
"bib19"
] | 19,687,230 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Double mutants in neighboring amino acids in IS6 and IIS6 confirmed this trend (Kudrnac et al., 2009). | [
"Hohaus et al., 2005",
"Kudrnac et al., 2009",
"Hohaus et al., 2005",
"Kudrnac et al., 2009"
] | 102 | 39,740 | 1 | false | Double mutants in neighboring amino acids in IS6 and IIS6 confirmed this trend. | [
"Kudrnac et al., 2009"
] | Double mutants in neighboring amino acids in IS6 and IIS6 confirmed this trend. | true | true | true | true | true | 6,863 |
2 | DISCUSSION | 1 | Yifrach and MacKinnon, 2002 | [
"bib28",
"bib31"
] | 19,687,230 | NA|NA|NA|NA | In potassium channels (Yifrach and MacKinnon, 2002) and NaChBac (Zhao et al., 2004), similar shifts of the activation curves were explained by a destabilization of the closed and/or a stabilization of the open-channel conformation without a perturbation of the voltage-sensing machinery. | [
"Yifrach and MacKinnon, 2002",
"Zhao et al., 2004"
] | 287 | 39,741 | 1 | false | In potassium channels and NaChBac, similar shifts of the activation curves were explained by a destabilization of the closed and/or a stabilization of the open-channel conformation without a perturbation of the voltage-sensing machinery. | [
"Yifrach and MacKinnon, 2002",
"Zhao et al., 2004"
] | In potassium channels and NaChBac, similar shifts of the activation curves were explained by a destabilization of the closed and/or a stabilization of the open-channel conformation without a perturbation of the voltage-sensing machinery. | true | true | true | true | true | 6,864 |
2 | DISCUSSION | 1 | Yifrach and MacKinnon, 2002 | [
"bib28",
"bib31"
] | 19,687,230 | NA|NA|NA|NA | In the present study, we evaluated this paradigm for CaV1.2. | [
"Yifrach and MacKinnon, 2002",
"Zhao et al., 2004"
] | 60 | 39,742 | 0 | false | In the present study, we evaluated this paradigm for CaV1.2. | [] | In the present study, we evaluated this paradigm for CaV1.2. | true | true | true | true | true | 6,864 |
3 | DISCUSSION | 0 | null | null | 19,687,230 | null | To quantify the underlying gating perturbations, we first exploited a serial three-state model (Scheme 1) with voltage-independent rate constants of pore opening and closure (α and β). | null | 184 | 39,743 | 0 | false | null | null | To quantify the underlying gating perturbations, we first exploited a serial three-state model (Scheme 1) with voltage-independent rate constants of pore opening and closure (α and β). | true | true | true | true | true | 6,865 |
3 | DISCUSSION | 0 | null | null | 19,687,230 | null | This gating scheme predicts increasing deactivation time constants with hyperpolarization, which is in contradiction to our experimental findings (Fig. | null | 151 | 39,744 | 0 | false | null | null | This gating scheme predicts increasing deactivation time constants with hyperpolarization, which is in contradiction to our experimental findings (Fig. | true | true | true | true | true | 6,865 |
3 | DISCUSSION | 0 | null | null | 19,687,230 | null | Therefore, to fit our data we designed a more complex, circular four-state model (Fig. | null | 86 | 39,745 | 0 | false | null | null | Therefore, to fit our data we designed a more complex, circular four-state model (Fig. | true | true | true | true | true | 6,865 |
3 | DISCUSSION | 0 | null | null | 19,687,230 | null | 1), where CaV1.2 channels can activate and deactivate via different pathways. | null | 77 | 39,746 | 0 | false | null | null | 1), where CaV1.2 channels can activate and deactivate via different pathways. | false | false | true | true | false | 6,865 |
3 | DISCUSSION | 0 | null | null | 19,687,230 | null | Both processes are initiated by voltage sensor movements. | null | 57 | 39,747 | 0 | false | null | null | Both processes are initiated by voltage sensor movements. | true | true | true | true | true | 6,865 |
3 | DISCUSSION | 0 | null | null | 19,687,230 | null | During activation the voltage sensor moves in response to a depolarization from a “gate-locking position” R to A (where the channel is still closed) with voltage-dependent rate constants x(V) and y(V). | null | 201 | 39,748 | 0 | false | null | null | During activation the voltage sensor moves in response to a depolarization from a “gate-locking position” R to A (where the channel is still closed) with voltage-dependent rate constants x(V) and y(V). | true | true | true | true | true | 6,865 |
3 | DISCUSSION | 0 | null | null | 19,687,230 | null | The unlocked channel opens with a rate constant α and closes with a rate constant β (Fig. | null | 89 | 39,749 | 0 | false | null | null | The unlocked channel opens with a rate constant α and closes with a rate constant β (Fig. | true | true | true | true | true | 6,865 |
3 | DISCUSSION | 0 | null | null | 19,687,230 | null | During deactivation the voltage sensor moves toward the “gate-locking position.” | null | 80 | 39,750 | 0 | false | null | null | During deactivation the voltage sensor moves toward the “gate-locking position.” | true | true | false | true | false | 6,865 |
3 | DISCUSSION | 0 | null | null | 19,687,230 | null | If channels sojourned in state A (activated/closed), they return to the resting state R. | null | 88 | 39,751 | 0 | false | null | null | If channels sojourned in state A (activated/closed), they return to the resting state R. | true | true | true | true | true | 6,865 |
3 | DISCUSSION | 0 | null | null | 19,687,230 | null | If channels were open, they enter the state D and subsequently close by returning to R. | null | 87 | 39,752 | 0 | false | null | null | If channels were open, they enter the state D and subsequently close by returning to R. | true | true | true | true | true | 6,865 |
4 | DISCUSSION | 0 | null | null | 19,687,230 | null | Voltage dependence of deactivation time constants predicted by fitting the data for mutant I781T to the backward activation pathway: O⇄A⇄R. | null | 139 | 39,753 | 0 | false | null | null | Voltage dependence of deactivation time constants predicted by fitting the data for mutant I781T to the backward activation pathway: O⇄A⇄R. | true | true | true | true | true | 6,866 |
4 | DISCUSSION | 0 | null | null | 19,687,230 | null | Deactivation time constant (solid line) was calculated by Eq. | null | 61 | 39,754 | 0 | false | null | null | Deactivation time constant (solid line) was calculated by Eq. | true | true | true | true | true | 6,866 |
4 | DISCUSSION | 0 | null | null | 19,687,230 | null | 2.2 (rate constants are indicated in Tables II and III). | null | 56 | 39,755 | 0 | false | null | null | 2.2 (rate constants are indicated in Tables II and III). | false | false | true | true | false | 6,866 |
4 | DISCUSSION | 0 | null | null | 19,687,230 | null | The model predicts an increase of the deactivation time constants, whereas the experimentally measured time constants decreased with increasing hyperpolarization (open circles connected by broken line). | null | 202 | 39,756 | 0 | false | null | null | The model predicts an increase of the deactivation time constants, whereas the experimentally measured time constants decreased with increasing hyperpolarization (open circles connected by broken line). | true | true | true | true | true | 6,866 |
5 | DISCUSSION | 0 | null | null | 19,687,230 | null | After an inverse problems approach, we determined: (1) the rate constants (x(V) and y(V)) of the transitions of the voltage-sensing machinery from the resting to the activated state, and (2) the rate constants of pore opening and closure (α, β, γ, and δ). | null | 255 | 39,757 | 0 | false | null | null | After an inverse problems approach, we determined: (1) the rate constants (x(V) and y(V)) of the transitions of the voltage-sensing machinery from the resting to the activated state, and (2) the rate constants of pore opening and closure (α, β, γ, and δ). | true | true | true | true | true | 6,867 |
5 | DISCUSSION | 0 | null | null | 19,687,230 | null | However, the application of this approach to individual channel mutants provided satisfactory fits with large confidence intervals (Table IV). | null | 142 | 39,758 | 0 | false | null | null | However, the application of this approach to individual channel mutants provided satisfactory fits with large confidence intervals (Table IV). | true | true | true | true | true | 6,867 |
5 | DISCUSSION | 0 | null | null | 19,687,230 | null | Assuming that the rate constants x(V) and y(V) are identical for all mutants allowed the identification of all rate constants with narrower confidence intervals (Figs. | null | 167 | 39,759 | 0 | false | null | null | Assuming that the rate constants x(V) and y(V) are identical for all mutants allowed the identification of all rate constants with narrower confidence intervals (Figs. | true | true | true | true | true | 6,867 |
5 | DISCUSSION | 0 | null | null | 19,687,230 | null | 3 and 8, and Tables I and II). | null | 30 | 39,760 | 0 | false | null | null | 3 and 8, and Tables I and II). | false | false | true | true | false | 6,867 |
5 | DISCUSSION | 0 | null | null | 19,687,230 | null | This approach enabled us to fit the kinetics of 15 out of 16 channel constructs (Figs. | null | 86 | 39,761 | 0 | false | null | null | This approach enabled us to fit the kinetics of 15 out of 16 channel constructs (Figs. | true | true | true | true | true | 6,867 |
5 | DISCUSSION | 0 | null | null | 19,687,230 | null | Simulations of current kinetics with estimated rate constants exemplified for wild type, I781G, and I781P (Fig. | null | 111 | 39,762 | 0 | false | null | null | Simulations of current kinetics with estimated rate constants exemplified for wild type, I781G, and I781P (Fig. | true | true | true | true | true | 6,867 |
5 | DISCUSSION | 0 | null | null | 19,687,230 | null | 4) illustrate the quality of the fit. | null | 37 | 39,763 | 0 | false | null | null | 4) illustrate the quality of the fit. | false | false | true | true | false | 6,867 |
6 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15"
] | 19,687,230 | NA | Steady-state and kinetic characteristics of previously described mutants (Hohaus et al., 2005). | [
"Hohaus et al., 2005"
] | 95 | 39,764 | 1 | false | Steady-state and kinetic characteristics of previously described mutants. | [
"Hohaus et al., 2005"
] | Steady-state and kinetic characteristics of previously described mutants. | true | true | true | true | true | 6,868 |
6 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15"
] | 19,687,230 | NA | Voltage dependencies of steady-state activation (A), time constants of activation (B; filled symbols), and deactivation (B; open symbols) of the indicated constructs. | [
"Hohaus et al., 2005"
] | 166 | 39,765 | 0 | false | Voltage dependencies of steady-state activation (A), time constants of activation (B; filled symbols), and deactivation (B; open symbols) of the indicated constructs. | [] | Voltage dependencies of steady-state activation (A), time constants of activation, and deactivation of the indicated constructs. | true | true | true | true | true | 6,868 |
6 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15"
] | 19,687,230 | NA | Solid lines represent the simulations based on the model parameters identified (see Tables II and III). | [
"Hohaus et al., 2005"
] | 103 | 39,766 | 0 | false | Solid lines represent the simulations based on the model parameters identified (see Tables II and III). | [] | Solid lines represent the simulations based on the model parameters identified. | true | true | true | true | true | 6,868 |
7 | DISCUSSION | 0 | null | null | 19,687,230 | null | Individually fitted model parameters for I781T and A780P | null | 56 | 39,767 | 0 | false | null | null | Individually fitted model parameters for I781T and A780P | true | true | false | true | false | 6,869 |
8 | DISCUSSION | 0 | null | null | 19,687,230 | null | Clear discrepancies between predicted and experimental data for mutant A780P are illustrated in Fig. | null | 100 | 39,768 | 0 | false | null | null | Clear discrepancies between predicted and experimental data for mutant A780P are illustrated in Fig. | true | true | true | true | true | 6,870 |
8 | DISCUSSION | 0 | null | null | 19,687,230 | null | Between −40 and −20 mV, the predicted time constants of channel activation of mutant A780P were approximately two times larger than the experimentally determined values (Fig. | null | 174 | 39,769 | 0 | false | null | null | Between −40 and −20 mV, the predicted time constants of channel activation of mutant A780P were approximately two times larger than the experimentally determined values (Fig. | true | true | true | true | true | 6,870 |
8 | DISCUSSION | 0 | null | null | 19,687,230 | null | 5 B, solid line). | null | 17 | 39,770 | 0 | false | null | null | 5 B, solid line). | false | false | true | true | false | 6,870 |
8 | DISCUSSION | 0 | null | null | 19,687,230 | null | Fitting the steady-state and current kinetics of A780P by the model individually led to a substantial improvement (Fig. | null | 119 | 39,771 | 0 | false | null | null | Fitting the steady-state and current kinetics of A780P by the model individually led to a substantial improvement (Fig. | true | true | true | true | true | 6,870 |
8 | DISCUSSION | 0 | null | null | 19,687,230 | null | 5, dashed lines). | null | 17 | 39,772 | 0 | false | null | null | 5, dashed lines). | false | false | true | true | false | 6,870 |
8 | DISCUSSION | 0 | null | null | 19,687,230 | null | A trend toward stronger voltage dependence of x(V) was observed (compare kx in Table IV with kx of all other mutants given in Table III). | null | 137 | 39,773 | 0 | false | null | null | A trend toward stronger voltage dependence of x(V) was observed (compare kx in Table IV with kx of all other mutants given in Table III). | true | true | true | true | true | 6,870 |
8 | DISCUSSION | 0 | null | null | 19,687,230 | null | We speculate that substitution of A780P in segment IIS6 of CaV1.2 significantly affects the interaction between the voltage-sensing machinery and the channel pore. | null | 163 | 39,774 | 0 | false | null | null | We speculate that substitution of A780P in segment IIS6 of CaV1.2 significantly affects the interaction between the voltage-sensing machinery and the channel pore. | true | true | true | true | true | 6,870 |
8 | DISCUSSION | 0 | null | null | 19,687,230 | null | Rigid helix bending in position A780 might be directed toward the voltage-sensing structures, leading to restricted mobility of the voltage-sensing domain (“sensor clip”). | null | 171 | 39,775 | 0 | false | null | null | Rigid helix bending in position A780 might be directed toward the voltage-sensing structures, leading to restricted mobility of the voltage-sensing domain (“sensor clip”). | true | true | true | true | true | 6,870 |
8 | DISCUSSION | 0 | null | null | 19,687,230 | null | Hence, the introduction of a flexible glycine into this position induced only an ∼10-mV shift of the activation curve without significantly changing current activation and deactivation kinetics (A780G; Figs. | null | 207 | 39,776 | 0 | false | null | null | Hence, the introduction of a flexible glycine into this position induced only an ∼10-mV shift of the activation curve without significantly changing current activation and deactivation kinetics (A780G; Figs. | true | true | true | true | true | 6,870 |
9 | DISCUSSION | 1 | Fedida and Hesketh, 2001 | [
"bib8"
] | 19,687,230 | NA | The voltage dependences of x(V) and of y(V) obtained for the other 15 constructs are shown in Fig. | [
"Fedida and Hesketh, 2001"
] | 98 | 39,777 | 0 | false | The voltage dependences of x(V) and of y(V) obtained for the other 15 constructs are shown in Fig. | [] | The voltage dependences of x(V) and of y(V) obtained for the other 15 constructs are shown in Fig. | true | true | true | true | true | 6,871 |
9 | DISCUSSION | 1 | Fedida and Hesketh, 2001 | [
"bib8"
] | 19,687,230 | NA | 6 C. Steeper dependence of y(V) on voltage (with ky = 9.04 ± 0.52 mV) compared with the “gate-releasing” movement (with a kx = 328 ± 447 mV) indicates that changes in membrane voltage are more efficient in closing than in opening the channel. | [
"Fedida and Hesketh, 2001"
] | 242 | 39,778 | 0 | false | 6 C. Steeper dependence of y(V) on voltage (with ky = 9.04 ± 0.52 mV) compared with the “gate-releasing” movement (with a kx = 328 ± 447 mV) indicates that changes in membrane voltage are more efficient in closing than in opening the channel. | [] | 6 C. Steeper dependence of y(V) on voltage compared with the “gate-releasing” movement indicates that changes in membrane voltage are more efficient in closing than in opening the channel. | false | false | true | true | false | 6,871 |
9 | DISCUSSION | 1 | Fedida and Hesketh, 2001 | [
"bib8"
] | 19,687,230 | NA | The weak voltage dependence of x(V) prevented a precise estimation of its steepness factor kx (wide confidence interval). | [
"Fedida and Hesketh, 2001"
] | 121 | 39,779 | 0 | false | The weak voltage dependence of x(V) prevented a precise estimation of its steepness factor kx (wide confidence interval). | [] | The weak voltage dependence of x(V) prevented a precise estimation of its steepness factor kx. | true | true | true | true | true | 6,871 |
9 | DISCUSSION | 1 | Fedida and Hesketh, 2001 | [
"bib8"
] | 19,687,230 | NA | Indeed, if current activation is determined largely by y(V), changes in x(V) have a minor (and hardly detectable) influence. | [
"Fedida and Hesketh, 2001"
] | 124 | 39,780 | 0 | false | Indeed, if current activation is determined largely by y(V), changes in x(V) have a minor (and hardly detectable) influence. | [] | Indeed, if current activation is determined largely by y(V), changes in x(V) have a minor influence. | true | true | true | true | true | 6,871 |
9 | DISCUSSION | 1 | Fedida and Hesketh, 2001 | [
"bib8"
] | 19,687,230 | NA | Weak voltage dependence of the forward rate constant of the voltage-sensing unit (x(V)) versus the strong voltage dependence of the backward transition (y(V)) suggests that the membrane voltage is more efficient in forcing the CaV1.2 into a closed state than “pulling” the gate open (Fig. | [
"Fedida and Hesketh, 2001"
] | 288 | 39,781 | 0 | false | Weak voltage dependence of the forward rate constant of the voltage-sensing unit (x(V)) versus the strong voltage dependence of the backward transition (y(V)) suggests that the membrane voltage is more efficient in forcing the CaV1.2 into a closed state than “pulling” the gate open (Fig. | [] | Weak voltage dependence of the forward rate constant of the voltage-sensing unit (x(V)) versus the strong voltage dependence of the backward transition (y(V)) suggests that the membrane voltage is more efficient in forcing the CaV1.2 into a closed state than “pulling” the gate open (Fig. | true | true | true | true | true | 6,871 |
9 | DISCUSSION | 1 | Fedida and Hesketh, 2001 | [
"bib8"
] | 19,687,230 | NA | 6 D), which is in line with previous observations on voltage-gated potassium channels (for review see Fedida and Hesketh, 2001). | [
"Fedida and Hesketh, 2001"
] | 128 | 39,782 | 0 | false | 6 D), which is in line with previous observations on voltage-gated potassium channels. | [
"for review see Fedida and Hesketh, 2001"
] | 6 D), which is in line with previous observations on voltage-gated potassium channels. | false | false | true | true | false | 6,871 |
10 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15",
"bib28",
"bib31"
] | 19,687,230 | NA|NA|NA | The majority of IIS6 mutations analyzed in this and a previous paper (Hohaus et al., 2005) shift the activation curve to more hyperpolarized voltages. | [
"Hohaus et al., 2005",
"Yifrach and MacKinnon, 2002",
"Zhao et al., 2004"
] | 150 | 39,783 | 1 | false | The majority of IIS6 mutations analyzed in this and a previous paper shift the activation curve to more hyperpolarized voltages. | [
"Hohaus et al., 2005"
] | The majority of IIS6 mutations analyzed in this and a previous paper shift the activation curve to more hyperpolarized voltages. | true | true | true | true | true | 6,872 |
10 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15",
"bib28",
"bib31"
] | 19,687,230 | NA|NA|NA | These changes in steady-state activation reflect either a destabilization of the closed state and/or a stabilization of the open-channel conformation (Yifrach and MacKinnon, 2002; Zhao et al., 2004). | [
"Hohaus et al., 2005",
"Yifrach and MacKinnon, 2002",
"Zhao et al., 2004"
] | 199 | 39,784 | 0 | false | These changes in steady-state activation reflect either a destabilization of the closed state and/or a stabilization of the open-channel conformation. | [
"Yifrach and MacKinnon, 2002; Zhao et al., 2004"
] | These changes in steady-state activation reflect either a destabilization of the closed state and/or a stabilization of the open-channel conformation. | true | true | true | true | true | 6,872 |
10 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15",
"bib28",
"bib31"
] | 19,687,230 | NA|NA|NA | Compared with previous studies, our analysis accounted for steady-state and kinetic data simultaneously. | [
"Hohaus et al., 2005",
"Yifrach and MacKinnon, 2002",
"Zhao et al., 2004"
] | 104 | 39,785 | 0 | false | Compared with previous studies, our analysis accounted for steady-state and kinetic data simultaneously. | [] | Compared with previous studies, our analysis accounted for steady-state and kinetic data simultaneously. | true | true | true | true | true | 6,872 |
10 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15",
"bib28",
"bib31"
] | 19,687,230 | NA|NA|NA | A trend that mutations in the lower part of IIS6 destabilizing the closed state stabilize the open state is evident (Fig. | [
"Hohaus et al., 2005",
"Yifrach and MacKinnon, 2002",
"Zhao et al., 2004"
] | 121 | 39,786 | 0 | false | A trend that mutations in the lower part of IIS6 destabilizing the closed state stabilize the open state is evident (Fig. | [] | A trend that mutations in the lower part of IIS6 destabilizing the closed state stabilize the open state is evident (Fig. | true | true | true | true | true | 6,872 |
10 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15",
"bib28",
"bib31"
] | 19,687,230 | NA|NA|NA | 6, A and B). | [
"Hohaus et al., 2005",
"Yifrach and MacKinnon, 2002",
"Zhao et al., 2004"
] | 12 | 39,787 | 0 | false | 6, A and B). | [] | 6, A and B). | false | false | true | true | false | 6,872 |
10 | DISCUSSION | 1 | Hohaus et al., 2005 | [
"bib15",
"bib28",
"bib31"
] | 19,687,230 | NA|NA|NA | This observation is an interesting finding per se and suggests a structural link between both conformations of CaV1.2 that has yet to be identified. | [
"Hohaus et al., 2005",
"Yifrach and MacKinnon, 2002",
"Zhao et al., 2004"
] | 148 | 39,788 | 0 | false | This observation is an interesting finding per se and suggests a structural link between both conformations of CaV1.2 that has yet to be identified. | [] | This observation is an interesting finding per se and suggests a structural link between both conformations of CaV1.2 that has yet to be identified. | true | true | true | true | true | 6,872 |
0 | INTRODUCTION | 0 | null | null | 18,984,621 | null | Synapses are the fundamental unit of computation in the brain playing key roles in information processing, behaviour and disease. | null | 129 | 39,789 | 0 | false | null | null | Synapses are the fundamental unit of computation in the brain playing key roles in information processing, behaviour and disease. | true | true | true | true | true | 6,873 |
0 | INTRODUCTION | 0 | null | null | 18,984,621 | null | They not only transmit information between cells but also detect patterns of neural activity and process this information by activating intracellular biochemical signalling pathways, which subsequently changes the properties of the neuron. | null | 239 | 39,790 | 0 | false | null | null | They not only transmit information between cells but also detect patterns of neural activity and process this information by activating intracellular biochemical signalling pathways, which subsequently changes the properties of the neuron. | true | true | true | true | true | 6,873 |
0 | INTRODUCTION | 0 | null | null | 18,984,621 | null | G2Cdb presents an integrated view of the role of synapses, focusing on large, high-quality datasets describing synaptic proteins and diseases of the nervous system, particularly those affecting cognition. | null | 204 | 39,791 | 0 | false | null | null | G2Cdb presents an integrated view of the role of synapses, focusing on large, high-quality datasets describing synaptic proteins and diseases of the nervous system, particularly those affecting cognition. | true | true | true | true | true | 6,873 |
1 | INTRODUCTION | 1 | 3 | [
"B3"
] | 18,984,621 | pmid-17110340 | Since the year 2000, proteomic studies have increased the number of known synaptic proteins over 10-fold and provided lists of proteins that represent the draft synapse proteome (1,2 and other references therein). | [
"3"
] | 213 | 39,792 | 0 | false | Since the year 2000, proteomic studies have increased the number of known synaptic proteins over 10-fold and provided lists of proteins that represent the draft synapse proteome (1,2 and other references therein). | [] | Since the year 2000, proteomic studies have increased the number of known synaptic proteins over 10-fold and provided lists of proteins that represent the draft synapse proteome (1,2 and other references therein). | true | true | true | true | true | 6,874 |
1 | INTRODUCTION | 1 | 3 | [
"B3"
] | 18,984,621 | pmid-17110340 | The synapse has different compartments, such as the post-synaptic proteome (PSP), comprising ∼1100 proteins, and pre-synaptic vesicles with ∼80 proteins (3). | [
"3"
] | 157 | 39,793 | 1 | false | The synapse has different compartments, such as the post-synaptic proteome (PSP), comprising ∼1100 proteins, and pre-synaptic vesicles with ∼80 proteins. | [
"3"
] | The synapse has different compartments, such as the post-synaptic proteome (PSP), comprising ∼1100 proteins, and pre-synaptic vesicles with ∼80 proteins. | true | true | true | true | true | 6,874 |
1 | INTRODUCTION | 1 | 3 | [
"B3"
] | 18,984,621 | pmid-17110340 | The high degree of complexity was unexpected and understanding the function of individual proteins and the overall organization of the molecular networks presents a major challenge. | [
"3"
] | 181 | 39,794 | 0 | false | The high degree of complexity was unexpected and understanding the function of individual proteins and the overall organization of the molecular networks presents a major challenge. | [] | The high degree of complexity was unexpected and understanding the function of individual proteins and the overall organization of the molecular networks presents a major challenge. | true | true | true | true | true | 6,874 |
2 | INTRODUCTION | 1 | 4 | [
"B4"
] | 18,984,621 | pmid-17098931 | G2Cdb aims to be the central database for warehousing data on the synaptic proteome. | [
"4"
] | 84 | 39,795 | 0 | false | G2Cdb aims to be the central database for warehousing data on the synaptic proteome. | [] | G2Cdb aims to be the central database for warehousing data on the synaptic proteome. | true | true | true | true | true | 6,875 |
2 | INTRODUCTION | 1 | 4 | [
"B4"
] | 18,984,621 | pmid-17098931 | Other useful databases exist for molecular neuroscience of which the closest is Synapse DataBase (SynDB). | [
"4"
] | 105 | 39,796 | 0 | false | Other useful databases exist for molecular neuroscience of which the closest is Synapse DataBase (SynDB). | [] | Other useful databases exist for molecular neuroscience of which the closest is Synapse DataBase (SynDB). | true | true | true | true | true | 6,875 |
2 | INTRODUCTION | 1 | 4 | [
"B4"
] | 18,984,621 | pmid-17098931 | G2Cdb differs fundamentally from SynDB both in terms of the data content and in the way it is constructed. | [
"4"
] | 106 | 39,797 | 0 | false | G2Cdb differs fundamentally from SynDB both in terms of the data content and in the way it is constructed. | [] | G2Cdb differs fundamentally from SynDB both in terms of the data content and in the way it is constructed. | true | true | true | true | true | 6,875 |
2 | INTRODUCTION | 1 | 4 | [
"B4"
] | 18,984,621 | pmid-17098931 | SynDB employs keyword and ontology-term searching of protein sequence and motif databases to provide an informatic definition of the synapse (4). | [
"4"
] | 145 | 39,798 | 1 | false | SynDB employs keyword and ontology-term searching of protein sequence and motif databases to provide an informatic definition of the synapse. | [
"4"
] | SynDB employs keyword and ontology-term searching of protein sequence and motif databases to provide an informatic definition of the synapse. | true | true | true | true | true | 6,875 |
2 | INTRODUCTION | 1 | 4 | [
"B4"
] | 18,984,621 | pmid-17098931 | In contrast, G2Cdb uses data curated from published studies of synaptic protein profiling to provide an experimentally validated representation of the mammalian synapse. | [
"4"
] | 169 | 39,799 | 0 | false | In contrast, G2Cdb uses data curated from published studies of synaptic protein profiling to provide an experimentally validated representation of the mammalian synapse. | [] | In contrast, G2Cdb uses data curated from published studies of synaptic protein profiling to provide an experimentally validated representation of the mammalian synapse. | true | true | true | true | true | 6,875 |
2 | INTRODUCTION | 1 | 4 | [
"B4"
] | 18,984,621 | pmid-17098931 | Both approaches, and thus databases, are highly complementary. | [
"4"
] | 62 | 39,800 | 0 | false | Both approaches, and thus databases, are highly complementary. | [] | Both approaches, and thus databases, are highly complementary. | true | true | true | true | true | 6,875 |
3 | INTRODUCTION | 0 | null | null | 18,984,621 | null | Building upon this proteomic definition of the synapse G2Cdb integrates mouse and human genomic annotation resources, forming the basis of a ‘molecular catalogue’ of mammalian synaptic genes. | null | 191 | 39,801 | 0 | false | null | null | Building upon this proteomic definition of the synapse G2Cdb integrates mouse and human genomic annotation resources, forming the basis of a ‘molecular catalogue’ of mammalian synaptic genes. | true | true | true | true | true | 6,876 |
3 | INTRODUCTION | 0 | null | null | 18,984,621 | null | Information mined from the human genetics literature reporting associations between synaptic gene mutations and disease is included, as is our in-depth and on-going survey of the neurobiological phenotypes observed in published studies of knockout and other transgenic mice. | null | 274 | 39,802 | 0 | false | null | null | Information mined from the human genetics literature reporting associations between synaptic gene mutations and disease is included, as is our in-depth and on-going survey of the neurobiological phenotypes observed in published studies of knockout and other transgenic mice. | true | true | true | true | true | 6,876 |
4 | INTRODUCTION | 1 | 5 | [
"B5"
] | 18,984,621 | pmid-16150739 | With the aim of presenting a global view of the role of synapses in physiology and disease, these datasets have been integrated in a gene-centric manner. | [
"5"
] | 153 | 39,803 | 0 | false | With the aim of presenting a global view of the role of synapses in physiology and disease, these datasets have been integrated in a gene-centric manner. | [] | With the aim of presenting a global view of the role of synapses in physiology and disease, these datasets have been integrated in a gene-centric manner. | true | true | true | true | true | 6,877 |
4 | INTRODUCTION | 1 | 5 | [
"B5"
] | 18,984,621 | pmid-16150739 | The resulting database, G2Cdb, should be of interest to all neuroscientists, clinicians and geneticists with interests in disease, given the ever-increasing number of synaptic proteins that are involved in human brain diseases such as Alzheimer's disease, autism, mental retardation and schizophrenia (5). | [
"5"
] | 305 | 39,804 | 1 | false | The resulting database, G2Cdb, should be of interest to all neuroscientists, clinicians and geneticists with interests in disease, given the ever-increasing number of synaptic proteins that are involved in human brain diseases such as Alzheimer's disease, autism, mental retardation and schizophrenia. | [
"5"
] | The resulting database, G2Cdb, should be of interest to all neuroscientists, clinicians and geneticists with interests in disease, given the ever-increasing number of synaptic proteins that are involved in human brain diseases such as Alzheimer's disease, autism, mental retardation and schizophrenia. | true | true | true | true | true | 6,877 |
5 | INTRODUCTION | 0 | null | null | 18,984,621 | null | G2Cdb can be freely accessed at www.genes2cognition.org. | null | 56 | 39,805 | 0 | false | null | null | G2Cdb can be freely accessed at www.genes2cognition.org. | true | true | true | true | true | 6,878 |
0 | DISCUSSION | 0 | null | null | 18,984,621 | null | Driven by the experimental progress in synapse proteomics and functional studies of these proteins, we identified a need for a specialist database for the organization and function of the synapse proteome. | null | 205 | 39,806 | 0 | false | null | null | Driven by the experimental progress in synapse proteomics and functional studies of these proteins, we identified a need for a specialist database for the organization and function of the synapse proteome. | true | true | true | true | true | 6,879 |
0 | DISCUSSION | 0 | null | null | 18,984,621 | null | This includes capturing detailed information from a number of sources of experimentally validated results, expert curated information from the literature and links to related external databases. | null | 194 | 39,807 | 0 | false | null | null | This includes capturing detailed information from a number of sources of experimentally validated results, expert curated information from the literature and links to related external databases. | true | true | true | true | true | 6,879 |
0 | DISCUSSION | 0 | null | null | 18,984,621 | null | Importantly, G2Cdb provides a mechanism for the effective re-use and analysis of a range of datasets that are expensive to curate/produce by the wider community. | null | 161 | 39,808 | 0 | false | null | null | Importantly, G2Cdb provides a mechanism for the effective re-use and analysis of a range of datasets that are expensive to curate/produce by the wider community. | true | true | true | true | true | 6,879 |
0 | DISCUSSION | 0 | null | null | 18,984,621 | null | The synapse proteome datasets that G2Cdb provides thus offer a basis for future research in synapse biology and provide useful information on brain diseases. | null | 157 | 39,809 | 0 | false | null | null | The synapse proteome datasets that G2Cdb provides thus offer a basis for future research in synapse biology and provide useful information on brain diseases. | true | true | true | true | true | 6,879 |
1 | DISCUSSION | 0 | null | null | 18,984,621 | pmid-17110340 | A major application of G2Cdb will be the assembly of molecular networks of the synapse proteome. | null | 96 | 39,810 | 0 | false | null | null | A major application of G2Cdb will be the assembly of molecular networks of the synapse proteome. | true | true | true | true | true | 6,880 |
1 | DISCUSSION | 0 | null | null | 18,984,621 | pmid-17110340 | These include transcriptional, protein interaction and phosphorylation networks. | null | 80 | 39,811 | 0 | false | null | null | These include transcriptional, protein interaction and phosphorylation networks. | true | true | true | true | true | 6,880 |
1 | DISCUSSION | 0 | null | null | 18,984,621 | pmid-17110340 | Combining this with phenotypic data on specific proteins in electrophysiology and behaviour from mice, and human disease information will be useful for the systems biology of the synapse. | null | 187 | 39,812 | 0 | false | null | null | Combining this with phenotypic data on specific proteins in electrophysiology and behaviour from mice, and human disease information will be useful for the systems biology of the synapse. | true | true | true | true | true | 6,880 |
2 | DISCUSSION | 0 | null | null | 18,984,621 | pmid-17098931 | Toward the public understanding of science and the education of school and undergraduates, we are collaborating with the Dolan DNA Learning Centre at Cold Spring Harbor Laboratory to provide G2Cdb in a format of use to school and college students. | null | 247 | 39,813 | 0 | false | null | null | Toward the public understanding of science and the education of school and undergraduates, we are collaborating with the Dolan DNA Learning Centre at Cold Spring Harbor Laboratory to provide G2Cdb in a format of use to school and college students. | true | true | true | true | true | 6,881 |
2 | DISCUSSION | 0 | null | null | 18,984,621 | pmid-17098931 | An educational website (www.g2conline.org) will cover a broad range of educational material on the subjects of genes and behaviour including novel network representations of the G2Cdb datasets. | null | 193 | 39,814 | 0 | false | null | null | An educational website (www.g2conline.org) will cover a broad range of educational material on the subjects of genes and behaviour including novel network representations of the G2Cdb datasets. | true | true | true | true | true | 6,881 |
0 | INTRODUCTION | 1 | 1 | [
"R1",
"R2"
] | 20,556,200 | NA|pmid-17624822|NA|NA|NA|pmid-16055883 | Tuberculosis is a leading cause of disease and death worldwide, especially in resource poor settings in the developing world [1]. | [
"1",
"2"
] | 129 | 39,815 | 1 | false | Tuberculosis is a leading cause of disease and death worldwide, especially in resource poor settings in the developing world. | [
"1"
] | Tuberculosis is a leading cause of disease and death worldwide, especially in resource poor settings in the developing world. | true | true | true | true | true | 6,882 |
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