paragraph_index int64 | sec string | p_has_citation int64 | cites string | citeids list | pmid int64 | cited_id string | sentences string | all_sent_cites list | sent_len int64 | sentence_batch_index int64 | sent_has_citation float64 | qc_fail bool | cited_sentence string | cites_in_sentence list | cln_sentence string | is_cap bool | is_alpha bool | ends_wp bool | cit_qc bool | lgtm bool | __index_level_0__ int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
2 | DISCUSSION | 1 | 4 | [
"B4"
] | 14,530,650 | pmid-11316320 | Among the cases described by Lee et al., ascites was uncommon, occurring in only two of the seven. | [
"4"
] | 98 | 41,019 | 0 | false | Among the cases described by Lee et al., ascites was uncommon, occurring in only two of the seven. | [] | Among the cases described by Lee et al., ascites was uncommon, occurring in only two of the seven. | true | true | true | true | true | 7,070 |
2 | DISCUSSION | 1 | 4 | [
"B4"
] | 14,530,650 | pmid-11316320 | Ascites was, however, demonstrated at ultrasonography in all our patients. | [
"4"
] | 74 | 41,020 | 0 | false | Ascites was, however, demonstrated at ultrasonography in all our patients. | [] | Ascites was, however, demonstrated at ultrasonography in all our patients. | true | true | true | true | true | 7,070 |
2 | DISCUSSION | 1 | 4 | [
"B4"
] | 14,530,650 | pmid-11316320 | In their report, color Doppler ultrasonography of SSTs revealed prominent vascularity in the peripheral portion and central intercystic spaces; power Doppler ultrasonography was not performed. | [
"4"
] | 192 | 41,021 | 0 | false | In their report, color Doppler ultrasonography of SSTs revealed prominent vascularity in the peripheral portion and central intercystic spaces; power Doppler ultrasonography was not performed. | [] | In their report, color Doppler ultrasonography of SSTs revealed prominent vascularity in the peripheral portion and central intercystic spaces; power Doppler ultrasonography was not performed. | true | true | true | true | true | 7,070 |
2 | DISCUSSION | 1 | 4 | [
"B4"
] | 14,530,650 | pmid-11316320 | In one of our patients, however, this modality showed a peculiar finding: the so-called "spoke-wheel appearance" , i.e., peripherally located arc-shaped large vessels and multiple vertically oriented centripetal vascular flow. | [
"4"
] | 226 | 41,022 | 0 | false | In one of our patients, however, this modality showed a peculiar finding: the so-called "spoke-wheel appearance", i.e., peripherally located arc-shaped large vessels and multiple vertically oriented centripetal vascular flow. | [] | In one of our patients, however, this modality showed a peculiar finding: the so-called "spoke-wheel appearance", i.e., peripherally located arc-shaped large vessels and multiple vertically oriented centripetal vascular flow. | true | true | true | true | true | 7,070 |
2 | DISCUSSION | 1 | 4 | [
"B4"
] | 14,530,650 | pmid-11316320 | We believe that because of its higher sensitivity to flow signals, power Doppler ultrasonography permits continuous delineation of vascular flow. | [
"4"
] | 145 | 41,023 | 0 | false | We believe that because of its higher sensitivity to flow signals, power Doppler ultrasonography permits continuous delineation of vascular flow. | [] | We believe that because of its higher sensitivity to flow signals, power Doppler ultrasonography permits continuous delineation of vascular flow. | true | true | true | true | true | 7,070 |
3 | DISCUSSION | 1 | 1 | [
"B1",
"B2",
"B5",
"B8",
"B2",
"B5",
"B8"
] | 14,530,650 | pmid-10433285|pmid-10460370|pmid-11242213|pmid-12432104|pmid-10460370|pmid-11242213|pmid-12432104 | The T2-weighted MRI findings of SSTs are a round or oval-shaped mass with hyperintense cystic components, and a heterogeneous solid component of intermediate to high signal intensity (1, 2, 5, 8). | [
"1",
"2",
"5",
"8",
"2",
"5",
"8"
] | 196 | 41,024 | 0 | false | The T2-weighted MRI findings of SSTs are a round or oval-shaped mass with hyperintense cystic components, and a heterogeneous solid component of intermediate to high signal intensity. | [
"1, 2, 5, 8"
] | The T2-weighted MRI findings of SSTs are a round or oval-shaped mass with hyperintense cystic components, and a heterogeneous solid component of intermediate to high signal intensity. | true | true | true | true | true | 7,071 |
3 | DISCUSSION | 1 | 1 | [
"B1",
"B2",
"B5",
"B8",
"B2",
"B5",
"B8"
] | 14,530,650 | pmid-10433285|pmid-10460370|pmid-11242213|pmid-12432104|pmid-10460370|pmid-11242213|pmid-12432104 | At dynamic contrast-enhanced imaging, early peripheral enhancement with centripetal progression has been reported (2, 5, 8). | [
"1",
"2",
"5",
"8",
"2",
"5",
"8"
] | 124 | 41,025 | 0 | false | At dynamic contrast-enhanced imaging, early peripheral enhancement with centripetal progression has been reported. | [
"2, 5, 8"
] | At dynamic contrast-enhanced imaging, early peripheral enhancement with centripetal progression has been reported. | true | true | true | true | true | 7,071 |
4 | DISCUSSION | 1 | 1 | [
"B1",
"B2",
"B1"
] | 14,530,650 | pmid-10433285|pmid-10460370|pmid-10433285 | Microscopically, SSTs are characterized by a number of distinctive features: 1) a pseudolobular growth pattern, in which cellular areas are separated by edematous and collagenous hypocellular areas; 2) collagenous sclerosis within the cellular areas; 3) marked vascularity, with a "hemangiopericytomatous" pattern; and 4... | [
"1",
"2",
"1"
] | 366 | 41,026 | 0 | false | Microscopically, SSTs are characterized by a number of distinctive features: 1) a pseudolobular growth pattern, in which cellular areas are separated by edematous and collagenous hypocellular areas; 2) collagenous sclerosis within the cellular areas; 3) marked vascularity, with a "hemangiopericytomatous" pattern; and 4... | [
"1, 2"
] | Microscopically, SSTs are characterized by a number of distinctive features: 1) a pseudolobular growth pattern, in which cellular areas are separated by edematous and collagenous hypocellular areas; 2) collagenous sclerosis within the cellular areas; 3) marked vascularity, with a "hemangiopericytomatous" pattern; and 4... | true | true | true | true | true | 7,072 |
4 | DISCUSSION | 1 | 1 | [
"B1",
"B2",
"B1"
] | 14,530,650 | pmid-10433285|pmid-10460370|pmid-10433285 | Except for this last-mentioned, our MR findings clearly reflected these pathologic features. | [
"1",
"2",
"1"
] | 92 | 41,027 | 0 | false | Except for this last-mentioned, our MR findings clearly reflected these pathologic features. | [] | Except for this last-mentioned, our MR findings clearly reflected these pathologic features. | true | true | true | true | true | 7,072 |
4 | DISCUSSION | 1 | 1 | [
"B1",
"B2",
"B1"
] | 14,530,650 | pmid-10433285|pmid-10460370|pmid-10433285 | At T2-weighted imaging, pseudolobulation was represented by an admixture of hypointense lesions set against a background of hyperintense stroma; pronounced sclerosis within the cellular nodules correlated with the hypointense areas. | [
"1",
"2",
"1"
] | 232 | 41,028 | 0 | false | At T2-weighted imaging, pseudolobulation was represented by an admixture of hypointense lesions set against a background of hyperintense stroma; pronounced sclerosis within the cellular nodules correlated with the hypointense areas. | [] | At T2-weighted imaging, pseudolobulation was represented by an admixture of hypointense lesions set against a background of hyperintense stroma; pronounced sclerosis within the cellular nodules correlated with the hypointense areas. | true | true | true | true | true | 7,072 |
4 | DISCUSSION | 1 | 1 | [
"B1",
"B2",
"B1"
] | 14,530,650 | pmid-10433285|pmid-10460370|pmid-10433285 | Prominent vascularity within cellular areas explained the marked and early tumoral enhancement we observed. | [
"1",
"2",
"1"
] | 107 | 41,029 | 0 | false | Prominent vascularity within cellular areas explained the marked and early tumoral enhancement we observed. | [] | Prominent vascularity within cellular areas explained the marked and early tumoral enhancement we observed. | true | true | true | true | true | 7,072 |
4 | DISCUSSION | 1 | 1 | [
"B1",
"B2",
"B1"
] | 14,530,650 | pmid-10433285|pmid-10460370|pmid-10433285 | Pathologic specimens obtained from our patients showed that the cystic areas were small; in fact the areas of high signal intensity seen at T2-weighted imaging and the unenhanced areas observed at dynamic imaging correlated with areas of hypocellularity and edema, and the thick or thin peripheral rim corresponded to th... | [
"1",
"2",
"1"
] | 360 | 41,030 | 0 | false | Pathologic specimens obtained from our patients showed that the cystic areas were small; in fact the areas of high signal intensity seen at T2-weighted imaging and the unenhanced areas observed at dynamic imaging correlated with areas of hypocellularity and edema, and the thick or thin peripheral rim corresponded to th... | [] | Pathologic specimens obtained from our patients showed that the cystic areas were small; in fact the areas of high signal intensity seen at T2-weighted imaging and the unenhanced areas observed at dynamic imaging correlated with areas of hypocellularity and edema, and the thick or thin peripheral rim corresponded to th... | true | true | true | true | true | 7,072 |
4 | DISCUSSION | 1 | 1 | [
"B1",
"B2",
"B1"
] | 14,530,650 | pmid-10433285|pmid-10460370|pmid-10433285 | In an earlier report, Ihara et al. | [
"1",
"2",
"1"
] | 34 | 41,031 | 0 | false | In an earlier report, Ihara et al. | [] | In an earlier report, Ihara et al. | true | true | true | true | true | 7,072 |
4 | DISCUSSION | 1 | 1 | [
"B1",
"B2",
"B1"
] | 14,530,650 | pmid-10433285|pmid-10460370|pmid-10433285 | (1) concluded that the presence of a thick peripheral rim consisting of compressed ovarian stroma can help differentiate SSTs from other stromal tumors. | [
"1",
"2",
"1"
] | 152 | 41,032 | 1 | false | concluded that the presence of a thick peripheral rim consisting of compressed ovarian stroma can help differentiate SSTs from other stromal tumors. | [
"1"
] | concluded that the presence of a thick peripheral rim consisting of compressed ovarian stroma can help differentiate SSTs from other stromal tumors. | false | true | true | true | false | 7,072 |
4 | DISCUSSION | 1 | 1 | [
"B1",
"B2",
"B1"
] | 14,530,650 | pmid-10433285|pmid-10460370|pmid-10433285 | SSTs, they claimed, have a thick peripheral rim for two reasons: first, they occur in younger women with large ovaries; second, the tumors are slow growing. | [
"1",
"2",
"1"
] | 156 | 41,033 | 0 | false | SSTs, they claimed, have a thick peripheral rim for two reasons: first, they occur in younger women with large ovaries; second, the tumors are slow growing. | [] | SSTs, they claimed, have a thick peripheral rim for two reasons: first, they occur in younger women with large ovaries; second, the tumors are slow growing. | true | true | true | true | true | 7,072 |
4 | DISCUSSION | 1 | 1 | [
"B1",
"B2",
"B1"
] | 14,530,650 | pmid-10433285|pmid-10460370|pmid-10433285 | Fibromas and thecomas, on the other hand, are common in older women with atrophied ovarian stroma that are hardly visible, even if present at a tumor's periphery. | [
"1",
"2",
"1"
] | 162 | 41,034 | 0 | false | Fibromas and thecomas, on the other hand, are common in older women with atrophied ovarian stroma that are hardly visible, even if present at a tumor's periphery. | [] | Fibromas and thecomas, on the other hand, are common in older women with atrophied ovarian stroma that are hardly visible, even if present at a tumor's periphery. | true | true | true | true | true | 7,072 |
4 | DISCUSSION | 1 | 1 | [
"B1",
"B2",
"B1"
] | 14,530,650 | pmid-10433285|pmid-10460370|pmid-10433285 | However, our report showed that the peripheral rim of SSTs varies in thickness, and may be very thin. | [
"1",
"2",
"1"
] | 101 | 41,035 | 0 | false | However, our report showed that the peripheral rim of SSTs varies in thickness, and may be very thin. | [] | However, our report showed that the peripheral rim of SSTs varies in thickness, and may be very thin. | true | true | true | true | true | 7,072 |
4 | DISCUSSION | 1 | 1 | [
"B1",
"B2",
"B1"
] | 14,530,650 | pmid-10433285|pmid-10460370|pmid-10433285 | In one of our patients (case 3), the peripheral ovarian cortex contained three functional cysts. | [
"1",
"2",
"1"
] | 96 | 41,036 | 0 | false | In one of our patients (case 3), the peripheral ovarian cortex contained three functional cysts. | [] | In one of our patients (case 3), the peripheral ovarian cortex contained three functional cysts. | true | true | true | true | true | 7,072 |
5 | DISCUSSION | 0 | null | null | 14,530,650 | null | The differential diagnosis of SSTs should include thecoma/fibroma, metastases, and malignant epithelial ovarian tumors. | null | 119 | 41,037 | 0 | false | null | null | The differential diagnosis of SSTs should include thecoma/fibroma, metastases, and malignant epithelial ovarian tumors. | true | true | true | true | true | 7,073 |
5 | DISCUSSION | 0 | null | null | 14,530,650 | null | Fibromas/thecomas usually show low signal intensities at T2-weighted imaging, and slow and prolonged enhancement at dynamic MRI. | null | 128 | 41,038 | 0 | false | null | null | Fibromas/thecomas usually show low signal intensities at T2-weighted imaging, and slow and prolonged enhancement at dynamic MRI. | true | true | true | true | true | 7,073 |
5 | DISCUSSION | 0 | null | null | 14,530,650 | null | Ovarian metastases and malignant epithelial tumors usually occur in older patients, and dynamic MR imaging does not usually reveal progressive centripetal enhancement. | null | 167 | 41,039 | 0 | false | null | null | Ovarian metastases and malignant epithelial tumors usually occur in older patients, and dynamic MR imaging does not usually reveal progressive centripetal enhancement. | true | true | true | true | true | 7,073 |
6 | DISCUSSION | 0 | null | null | 14,530,650 | null | In summary, SSTs are mixed cystic and solid tumors with central round or cleft-like cysts and show quite specific imaging findings, especially at power Doppler ultrasonography and dynamic MRI. | null | 192 | 41,040 | 0 | false | null | null | In summary, SSTs are mixed cystic and solid tumors with central round or cleft-like cysts and show quite specific imaging findings, especially at power Doppler ultrasonography and dynamic MRI. | true | true | true | true | true | 7,074 |
6 | DISCUSSION | 0 | null | null | 14,530,650 | null | Findings of large peripherally located vessels and centripetal vascular flow ("spoke-wheel appearance") at power Doppler ultrasonography, and early peripheral enhancement with centripetal progression at dynamic MRI, are usual. | null | 226 | 41,041 | 0 | false | null | null | Findings of large peripherally located vessels and centripetal vascular flow ("spoke-wheel appearance") at power Doppler ultrasonography, and early peripheral enhancement with centripetal progression at dynamic MRI, are usual. | true | true | true | true | true | 7,074 |
6 | DISCUSSION | 0 | null | null | 14,530,650 | null | Acknowledgment of these specific findings of SSTs permits the accurate preoperative diagnosis of these benign tumors and promotes less invasive surgery (such as laparoscopic tumor excision) rather than oophorectomy. | null | 215 | 41,042 | 0 | false | null | null | Acknowledgment of these specific findings of SSTs permits the accurate preoperative diagnosis of these benign tumors and promotes less invasive surgery (such as laparoscopic tumor excision) rather than oophorectomy. | true | true | true | true | true | 7,074 |
0 | DISCUSSION | 1 | 19 | [
"ref19",
"ref11",
"ref12",
"ref13",
"ref11"
] | 18,408,006 | pmid-15304394|pmid-15845454|pmid-16174766|pmid-17339324|pmid-15845454 | We describe here the first characterization of human CLEC9A and demonstrate that it functions as an activation receptor, capable of triggering intracellular signaling via Syk kinase. | [
"19",
"11",
"12",
"13",
"11"
] | 182 | 41,043 | 0 | false | We describe here the first characterization of human CLEC9A and demonstrate that it functions as an activation receptor, capable of triggering intracellular signaling via Syk kinase. | [] | We describe here the first characterization of human CLEC9A and demonstrate that it functions as an activation receptor, capable of triggering intracellular signaling via Syk kinase. | true | true | true | true | true | 7,075 |
0 | DISCUSSION | 1 | 19 | [
"ref19",
"ref11",
"ref12",
"ref13",
"ref11"
] | 18,408,006 | pmid-15304394|pmid-15845454|pmid-16174766|pmid-17339324|pmid-15845454 | This interaction is mediated by the cytoplasmic tail of the CLEC9A that contains a single tyrosine-based (EXYXXL) sequence, which can be considered to be an ITAM-like motif (19). | [
"19",
"11",
"12",
"13",
"11"
] | 178 | 41,044 | 1 | false | This interaction is mediated by the cytoplasmic tail of the CLEC9A that contains a single tyrosine-based (EXYXXL) sequence, which can be considered to be an ITAM-like motif. | [
"19"
] | This interaction is mediated by the cytoplasmic tail of the CLEC9A that contains a single tyrosine-based (EXYXXL) sequence, which can be considered to be an ITAM-like motif. | true | true | true | true | true | 7,075 |
0 | DISCUSSION | 1 | 11 | [
"ref19",
"ref11",
"ref12",
"ref13",
"ref11"
] | 18,408,006 | pmid-15304394|pmid-15845454|pmid-16174766|pmid-17339324|pmid-15845454 | These sequences were first identified in two other receptors of the Dectin-1 cluster, Dectin-1 itself (11), and more recently CLEC-2 (12). | [
"19",
"11",
"12",
"13",
"11"
] | 138 | 41,045 | 1 | false | These sequences were first identified in two other receptors of the Dectin-1 cluster, Dectin-1 itself, and more recently CLEC-2. | [
"11",
"12"
] | These sequences were first identified in two other receptors of the Dectin-1 cluster, Dectin-1 itself, and more recently CLEC-2. | true | true | true | true | true | 7,075 |
0 | DISCUSSION | 1 | 11 | [
"ref19",
"ref11",
"ref12",
"ref13",
"ref11"
] | 18,408,006 | pmid-15304394|pmid-15845454|pmid-16174766|pmid-17339324|pmid-15845454 | While the mechanism of Syk signaling via these motifs is unknown, it requires both SH2 domains of this kinase (13) and may occur via bridging of two receptor chains (11). | [
"19",
"11",
"12",
"13",
"11"
] | 170 | 41,046 | 1 | false | While the mechanism of Syk signaling via these motifs is unknown, it requires both SH2 domains of this kinase and may occur via bridging of two receptor chains. | [
"13",
"11"
] | While the mechanism of Syk signaling via these motifs is unknown, it requires both SH2 domains of this kinase and may occur via bridging of two receptor chains. | true | true | true | true | true | 7,075 |
1 | DISCUSSION | 1 | 30 | [
"ref30",
"ref27",
"ref31",
"ref31"
] | 18,408,006 | pmid-16862125|pmid-16341139|pmid-17450144|pmid-17450144 | In myeloid cells, ITAM-like mediated signaling through Syk has largely been studied with Dectin-1. | [
"30",
"27",
"31",
"31"
] | 98 | 41,047 | 0 | false | In myeloid cells, ITAM-like mediated signaling through Syk has largely been studied with Dectin-1. | [] | In myeloid cells, ITAM-like mediated signaling through Syk has largely been studied with Dectin-1. | true | true | true | true | true | 7,076 |
1 | DISCUSSION | 1 | 30 | [
"ref30",
"ref27",
"ref31",
"ref31"
] | 18,408,006 | pmid-16862125|pmid-16341139|pmid-17450144|pmid-17450144 | Signaling via this kinase occurs through a novel pathway involving CARD9 (30) and can induce a variety of cellular responses including the induction of cytokines (such as TNF, IL-6, IL-10, IL-23, and IL-2), the respiratory burst, and the production of arachidonic acid (27, 31). | [
"30",
"27",
"31",
"31"
] | 278 | 41,048 | 1 | false | Signaling via this kinase occurs through a novel pathway involving CARD9 and can induce a variety of cellular responses including the induction of cytokines (such as TNF, IL-6, IL-10, IL-23, and IL-2), the respiratory burst, and the production of arachidonic acid. | [
"30",
"27, 31"
] | Signaling via this kinase occurs through a novel pathway involving CARD9 and can induce a variety of cellular responses including the induction of cytokines, the respiratory burst, and the production of arachidonic acid. | true | true | true | true | true | 7,076 |
1 | DISCUSSION | 1 | 31 | [
"ref30",
"ref27",
"ref31",
"ref31"
] | 18,408,006 | pmid-16862125|pmid-16341139|pmid-17450144|pmid-17450144 | In addition, signaling via this pathway was recently shown to induce T-helper type 17 (TH17) adaptive responses in vivo (31). | [
"30",
"27",
"31",
"31"
] | 125 | 41,049 | 1 | false | In addition, signaling via this pathway was recently shown to induce T-helper type 17 (TH17) adaptive responses in vivo. | [
"31"
] | In addition, signaling via this pathway was recently shown to induce T-helper type 17 adaptive responses in vivo. | true | true | true | true | true | 7,076 |
1 | DISCUSSION | 1 | 30 | [
"ref30",
"ref27",
"ref31",
"ref31"
] | 18,408,006 | pmid-16862125|pmid-16341139|pmid-17450144|pmid-17450144 | As CLEC9A can signal via this pathway, it is possible that this receptor may be able to induce many, if not all, of these responses, which may be influenced by its ability to dimerize. | [
"30",
"27",
"31",
"31"
] | 184 | 41,050 | 0 | false | As CLEC9A can signal via this pathway, it is possible that this receptor may be able to induce many, if not all, of these responses, which may be influenced by its ability to dimerize. | [] | As CLEC9A can signal via this pathway, it is possible that this receptor may be able to induce many, if not all, of these responses, which may be influenced by its ability to dimerize. | true | true | true | true | true | 7,076 |
2 | DISCUSSION | 1 | 19 | [
"ref19",
"ref32",
"ref19",
"ref33"
] | 18,408,006 | pmid-15304394|NA|pmid-15304394|pmid-15956283 | The ITAM-like motif of Dectin-1 also mediates phagocytosis (19). | [
"19",
"32",
"19",
"33"
] | 64 | 41,051 | 1 | false | The ITAM-like motif of Dectin-1 also mediates phagocytosis. | [
"19"
] | The ITAM-like motif of Dectin-1 also mediates phagocytosis. | true | true | true | true | true | 7,077 |
2 | DISCUSSION | 1 | 19 | [
"ref19",
"ref32",
"ref19",
"ref33"
] | 18,408,006 | pmid-15304394|NA|pmid-15304394|pmid-15956283 | Although we could demonstrate that CLEC9A could induce particle uptake in macrophages, it was unable to do so when expressed in NIH3T3 cells. | [
"19",
"32",
"19",
"33"
] | 141 | 41,052 | 0 | false | Although we could demonstrate that CLEC9A could induce particle uptake in macrophages, it was unable to do so when expressed in NIH3T3 cells. | [] | Although we could demonstrate that CLEC9A could induce particle uptake in macrophages, it was unable to do so when expressed in NIH3T3 cells. | true | true | true | true | true | 7,077 |
2 | DISCUSSION | 1 | 19 | [
"ref19",
"ref32",
"ref19",
"ref33"
] | 18,408,006 | pmid-15304394|NA|pmid-15304394|pmid-15956283 | As the definition of a phagocytic receptor is its ability to confer phagocytic activity to normally non-phagocytic cell lines, we conclude that CLEC9A is not directly able to mediate particle uptake. | [
"19",
"32",
"19",
"33"
] | 199 | 41,053 | 0 | false | As the definition of a phagocytic receptor is its ability to confer phagocytic activity to normally non-phagocytic cell lines, we conclude that CLEC9A is not directly able to mediate particle uptake. | [] | As the definition of a phagocytic receptor is its ability to confer phagocytic activity to normally non-phagocytic cell lines, we conclude that CLEC9A is not directly able to mediate particle uptake. | true | true | true | true | true | 7,077 |
2 | DISCUSSION | 1 | 32 | [
"ref19",
"ref32",
"ref19",
"ref33"
] | 18,408,006 | pmid-15304394|NA|pmid-15304394|pmid-15956283 | In the RAW264.7 macrophages, it is possible that the residual low levels of endogenous Dectin-1 were contributing to this process (32). | [
"19",
"32",
"19",
"33"
] | 135 | 41,054 | 1 | false | In the RAW264.7 macrophages, it is possible that the residual low levels of endogenous Dectin-1 were contributing to this process. | [
"32"
] | In the RAW264.7 macrophages, it is possible that the residual low levels of endogenous Dectin-1 were contributing to this process. | true | true | true | true | true | 7,077 |
2 | DISCUSSION | 1 | 19 | [
"ref19",
"ref32",
"ref19",
"ref33"
] | 18,408,006 | pmid-15304394|NA|pmid-15304394|pmid-15956283 | In addition Dectin-1-mediated phagocytosis occurs through novel mechanisms (19), which are still undefined and requires additional tyrosine-proximal residues (33) that are absent in CLEC9A. | [
"19",
"32",
"19",
"33"
] | 189 | 41,055 | 1 | false | In addition Dectin-1-mediated phagocytosis occurs through novel mechanisms, which are still undefined and requires additional tyrosine-proximal residues that are absent in CLEC9A. | [
"19",
"33"
] | In addition Dectin-1-mediated phagocytosis occurs through novel mechanisms, which are still undefined and requires additional tyrosine-proximal residues that are absent in CLEC9A. | true | true | true | true | true | 7,077 |
3 | DISCUSSION | 0 | null | null | 18,408,006 | null | FIGURE 5.hCLEC9A is not a phagocytic receptor. | null | 47 | 41,056 | 0 | false | null | null | FIGURE 5.hCLEC9A is not a phagocytic receptor. | false | false | true | true | false | 7,078 |
3 | DISCUSSION | 0 | null | null | 18,408,006 | null | A, schematic representation of the chimeric Dectin-1/CLEC9A receptor. | null | 69 | 41,057 | 0 | false | null | null | A, schematic representation of the chimeric Dectin-1/CLEC9A receptor. | true | true | true | true | true | 7,078 |
3 | DISCUSSION | 0 | null | null | 18,408,006 | null | B, fluorometric quantitation of zymosan (zym) binding by the transduced RAW264.7 macrophages or NIH3T3 fibroblasts, in the presence or absence of soluble β-glucan (β-glu), as indicated. | null | 185 | 41,058 | 0 | false | null | null | B, fluorometric quantitation of zymosan (zym) binding by the transduced RAW264.7 macrophages or NIH3T3 fibroblasts, in the presence or absence of soluble β-glucan (β-glu), as indicated. | true | true | true | true | true | 7,078 |
3 | DISCUSSION | 0 | null | null | 18,408,006 | null | RFU, relative fluorescence units. | null | 33 | 41,059 | 0 | false | null | null | RFU, relative fluorescence units. | true | true | true | true | true | 7,078 |
3 | DISCUSSION | 0 | null | null | 18,408,006 | null | Shown are the mean ± S.D. | null | 25 | 41,060 | 0 | false | null | null | Shown are the mean ± S.D. | true | true | true | true | true | 7,078 |
3 | DISCUSSION | 0 | null | null | 18,408,006 | null | of one representative experiment of three. | null | 42 | 41,061 | 0 | false | null | null | of one representative experiment of three. | false | true | true | true | false | 7,078 |
3 | DISCUSSION | 0 | null | null | 18,408,006 | null | C, flow cytometric quantitation of zymosan uptake (black histograms) by the chimera or Dectin-1 expressing RAW264.7 macrophages or NIH3T3 fibroblasts, as indicated. | null | 164 | 41,062 | 0 | false | null | null | C, flow cytometric quantitation of zymosan uptake (black histograms) by the chimera or Dectin-1 expressing RAW264.7 macrophages or NIH3T3 fibroblasts, as indicated. | true | true | true | true | true | 7,078 |
3 | DISCUSSION | 0 | null | null | 18,408,006 | null | Cytochalasin D (gray-filled histograms) was used to inhibit actin polymerization and served as a control in this assay. | null | 119 | 41,063 | 0 | false | null | null | Cytochalasin D (gray-filled histograms) was used to inhibit actin polymerization and served as a control in this assay. | true | true | true | true | true | 7,078 |
3 | DISCUSSION | 0 | null | null | 18,408,006 | null | The histograms shown are representative of at least three independent experiments, and the bars indicate the percentage of cells with internalized particles. | null | 157 | 41,064 | 0 | false | null | null | The histograms shown are representative of at least three independent experiments, and the bars indicate the percentage of cells with internalized particles. | true | true | true | true | true | 7,078 |
3 | DISCUSSION | 0 | null | null | 18,408,006 | null | *, p < 0.05 versus control (Student's t test). | null | 46 | 41,065 | 0 | false | null | null | *, p < 0.05 versus control (Student's t test). | false | false | true | true | false | 7,078 |
3 | DISCUSSION | 0 | null | null | 18,408,006 | null | D, representative confocal images demonstrating FITC-zymosan (green) uptake in NIH3T3 fibroblasts transduced with Dectin-1, but not the chimeric receptor. | null | 154 | 41,066 | 0 | false | null | null | D, representative confocal images demonstrating FITC-zymosan (green) uptake in NIH3T3 fibroblasts transduced with Dectin-1, but not the chimeric receptor. | true | true | true | true | true | 7,078 |
3 | DISCUSSION | 0 | null | null | 18,408,006 | null | Actin was stained with TRITC-phallodin, and is shown in red. | null | 60 | 41,067 | 0 | false | null | null | Actin was stained with TRITC-phallodin, and is shown in red. | true | true | true | true | true | 7,078 |
4 | DISCUSSION | 0 | null | null | 18,408,006 | null | hCLEC9A is not a phagocytic receptor. | null | 37 | 41,068 | 0 | false | null | null | hCLEC9A is not a phagocytic receptor. | false | true | true | true | false | 7,079 |
4 | DISCUSSION | 0 | null | null | 18,408,006 | null | A, schematic representation of the chimeric Dectin-1/CLEC9A receptor. | null | 69 | 41,069 | 0 | false | null | null | A, schematic representation of the chimeric Dectin-1/CLEC9A receptor. | true | true | true | true | true | 7,079 |
4 | DISCUSSION | 0 | null | null | 18,408,006 | null | B, fluorometric quantitation of zymosan (zym) binding by the transduced RAW264.7 macrophages or NIH3T3 fibroblasts, in the presence or absence of soluble β-glucan (β-glu), as indicated. | null | 185 | 41,070 | 0 | false | null | null | B, fluorometric quantitation of zymosan (zym) binding by the transduced RAW264.7 macrophages or NIH3T3 fibroblasts, in the presence or absence of soluble β-glucan (β-glu), as indicated. | true | true | true | true | true | 7,079 |
4 | DISCUSSION | 0 | null | null | 18,408,006 | null | RFU, relative fluorescence units. | null | 33 | 41,071 | 0 | false | null | null | RFU, relative fluorescence units. | true | true | true | true | true | 7,079 |
4 | DISCUSSION | 0 | null | null | 18,408,006 | null | Shown are the mean ± S.D. | null | 25 | 41,072 | 0 | false | null | null | Shown are the mean ± S.D. | true | true | true | true | true | 7,079 |
4 | DISCUSSION | 0 | null | null | 18,408,006 | null | of one representative experiment of three. | null | 42 | 41,073 | 0 | false | null | null | of one representative experiment of three. | false | true | true | true | false | 7,079 |
4 | DISCUSSION | 0 | null | null | 18,408,006 | null | C, flow cytometric quantitation of zymosan uptake (black histograms) by the chimera or Dectin-1 expressing RAW264.7 macrophages or NIH3T3 fibroblasts, as indicated. | null | 164 | 41,074 | 0 | false | null | null | C, flow cytometric quantitation of zymosan uptake (black histograms) by the chimera or Dectin-1 expressing RAW264.7 macrophages or NIH3T3 fibroblasts, as indicated. | true | true | true | true | true | 7,079 |
4 | DISCUSSION | 0 | null | null | 18,408,006 | null | Cytochalasin D (gray-filled histograms) was used to inhibit actin polymerization and served as a control in this assay. | null | 119 | 41,075 | 0 | false | null | null | Cytochalasin D (gray-filled histograms) was used to inhibit actin polymerization and served as a control in this assay. | true | true | true | true | true | 7,079 |
4 | DISCUSSION | 0 | null | null | 18,408,006 | null | The histograms shown are representative of at least three independent experiments, and the bars indicate the percentage of cells with internalized particles. | null | 157 | 41,076 | 0 | false | null | null | The histograms shown are representative of at least three independent experiments, and the bars indicate the percentage of cells with internalized particles. | true | true | true | true | true | 7,079 |
4 | DISCUSSION | 0 | null | null | 18,408,006 | null | *, p < 0.05 versus control (Student's t test). | null | 46 | 41,077 | 0 | false | null | null | *, p < 0.05 versus control (Student's t test). | false | false | true | true | false | 7,079 |
4 | DISCUSSION | 0 | null | null | 18,408,006 | null | D, representative confocal images demonstrating FITC-zymosan (green) uptake in NIH3T3 fibroblasts transduced with Dectin-1, but not the chimeric receptor. | null | 154 | 41,078 | 0 | false | null | null | D, representative confocal images demonstrating FITC-zymosan (green) uptake in NIH3T3 fibroblasts transduced with Dectin-1, but not the chimeric receptor. | true | true | true | true | true | 7,079 |
4 | DISCUSSION | 0 | null | null | 18,408,006 | null | Actin was stained with TRITC-phallodin, and is shown in red. | null | 60 | 41,079 | 0 | false | null | null | Actin was stained with TRITC-phallodin, and is shown in red. | true | true | true | true | true | 7,079 |
5 | DISCUSSION | 0 | null | null | 18,408,006 | null | FIGURE 6.hCLEC9A can induce pro-inflammatory cytokine production and can recruit and signal via Syk kinase. | null | 108 | 41,080 | 0 | false | null | null | FIGURE 6.hCLEC9A can induce pro-inflammatory cytokine production and can recruit and signal via Syk kinase. | false | false | true | true | false | 7,080 |
5 | DISCUSSION | 0 | null | null | 18,408,006 | null | A, quantitation of zymosan (zym) induced TNF production by transduced RAW264.7 macrophages, in the presence or absence of soluble β-glucan (β-glu), as indicated, demonstrating the ability of the chimeric receptor to induce proinflammatory cytokine production. | null | 259 | 41,081 | 0 | false | null | null | A, quantitation of zymosan (zym) induced TNF production by transduced RAW264.7 macrophages, in the presence or absence of soluble β-glucan (β-glu), as indicated, demonstrating the ability of the chimeric receptor to induce proinflammatory cytokine production. | true | true | true | true | true | 7,080 |
5 | DISCUSSION | 0 | null | null | 18,408,006 | null | Shown are the mean ± S.D. | null | 25 | 41,082 | 0 | false | null | null | Shown are the mean ± S.D. | true | true | true | true | true | 7,080 |
5 | DISCUSSION | 0 | null | null | 18,408,006 | null | of one representative experiment of three. | null | 42 | 41,083 | 0 | false | null | null | of one representative experiment of three. | false | true | true | true | false | 7,080 |
5 | DISCUSSION | 0 | null | null | 18,408,006 | null | B, Western blotting of immunoprecipitates using phosphorylated (pY) and unphosphorylated peptides (Y) corresponding to the cytoplasmic tail of hCLEC9A or Dectin-1 from RAW264.7 cell lysates. | null | 190 | 41,084 | 0 | false | null | null | B, Western blotting of immunoprecipitates using phosphorylated (pY) and unphosphorylated peptides (Y) corresponding to the cytoplasmic tail of hCLEC9A or Dectin-1 from RAW264.7 cell lysates. | true | true | true | true | true | 7,080 |
5 | DISCUSSION | 0 | null | null | 18,408,006 | null | Blots were probed with anti-phosphotyrosine (αPY), anti-Syk, and anti-Lyn, as indicated. | null | 88 | 41,085 | 0 | false | null | null | Blots were probed with anti-phosphotyrosine (αPY), anti-Syk, and anti-Lyn, as indicated. | true | true | true | true | true | 7,080 |
5 | DISCUSSION | 0 | null | null | 18,408,006 | null | C, IL-2 production following zymosan stimulation of Syk-deficient (Syk-) and Syk-sufficient (Syk+) cells, transduced with the chimeric receptor or vector-only control, as indicated, showing that cytokine production induced by the chimeric receptor in response to zymosan requires Syk. | null | 284 | 41,086 | 0 | false | null | null | C, IL-2 production following zymosan stimulation of Syk-deficient (Syk-) and Syk-sufficient (Syk+) cells, transduced with the chimeric receptor or vector-only control, as indicated, showing that cytokine production induced by the chimeric receptor in response to zymosan requires Syk. | true | true | true | true | true | 7,080 |
5 | DISCUSSION | 0 | null | null | 18,408,006 | null | The data shown are the mean ± S.D. | null | 34 | 41,087 | 0 | false | null | null | The data shown are the mean ± S.D. | true | true | true | true | true | 7,080 |
5 | DISCUSSION | 0 | null | null | 18,408,006 | null | and are representative of three independent experiments. | null | 56 | 41,088 | 0 | false | null | null | and are representative of three independent experiments. | false | true | true | true | false | 7,080 |
5 | DISCUSSION | 0 | null | null | 18,408,006 | null | *, p < 0.05 versus control (Student's t test). | null | 46 | 41,089 | 0 | false | null | null | *, p < 0.05 versus control (Student's t test). | false | false | true | true | false | 7,080 |
6 | DISCUSSION | 0 | null | null | 18,408,006 | null | hCLEC9A can induce pro-inflammatory cytokine production and can recruit and signal via Syk kinase. | null | 98 | 41,090 | 0 | false | null | null | hCLEC9A can induce pro-inflammatory cytokine production and can recruit and signal via Syk kinase. | false | true | true | true | false | 7,081 |
6 | DISCUSSION | 0 | null | null | 18,408,006 | null | A, quantitation of zymosan (zym) induced TNF production by transduced RAW264.7 macrophages, in the presence or absence of soluble β-glucan (β-glu), as indicated, demonstrating the ability of the chimeric receptor to induce proinflammatory cytokine production. | null | 259 | 41,091 | 0 | false | null | null | A, quantitation of zymosan (zym) induced TNF production by transduced RAW264.7 macrophages, in the presence or absence of soluble β-glucan (β-glu), as indicated, demonstrating the ability of the chimeric receptor to induce proinflammatory cytokine production. | true | true | true | true | true | 7,081 |
6 | DISCUSSION | 0 | null | null | 18,408,006 | null | Shown are the mean ± S.D. | null | 25 | 41,092 | 0 | false | null | null | Shown are the mean ± S.D. | true | true | true | true | true | 7,081 |
6 | DISCUSSION | 0 | null | null | 18,408,006 | null | of one representative experiment of three. | null | 42 | 41,093 | 0 | false | null | null | of one representative experiment of three. | false | true | true | true | false | 7,081 |
6 | DISCUSSION | 0 | null | null | 18,408,006 | null | B, Western blotting of immunoprecipitates using phosphorylated (pY) and unphosphorylated peptides (Y) corresponding to the cytoplasmic tail of hCLEC9A or Dectin-1 from RAW264.7 cell lysates. | null | 190 | 41,094 | 0 | false | null | null | B, Western blotting of immunoprecipitates using phosphorylated (pY) and unphosphorylated peptides (Y) corresponding to the cytoplasmic tail of hCLEC9A or Dectin-1 from RAW264.7 cell lysates. | true | true | true | true | true | 7,081 |
6 | DISCUSSION | 0 | null | null | 18,408,006 | null | Blots were probed with anti-phosphotyrosine (αPY), anti-Syk, and anti-Lyn, as indicated. | null | 88 | 41,095 | 0 | false | null | null | Blots were probed with anti-phosphotyrosine (αPY), anti-Syk, and anti-Lyn, as indicated. | true | true | true | true | true | 7,081 |
6 | DISCUSSION | 0 | null | null | 18,408,006 | null | C, IL-2 production following zymosan stimulation of Syk-deficient (Syk-) and Syk-sufficient (Syk+) cells, transduced with the chimeric receptor or vector-only control, as indicated, showing that cytokine production induced by the chimeric receptor in response to zymosan requires Syk. | null | 284 | 41,096 | 0 | false | null | null | C, IL-2 production following zymosan stimulation of Syk-deficient (Syk-) and Syk-sufficient (Syk+) cells, transduced with the chimeric receptor or vector-only control, as indicated, showing that cytokine production induced by the chimeric receptor in response to zymosan requires Syk. | true | true | true | true | true | 7,081 |
6 | DISCUSSION | 0 | null | null | 18,408,006 | null | The data shown are the mean ± S.D. | null | 34 | 41,097 | 0 | false | null | null | The data shown are the mean ± S.D. | true | true | true | true | true | 7,081 |
6 | DISCUSSION | 0 | null | null | 18,408,006 | null | and are representative of three independent experiments. | null | 56 | 41,098 | 0 | false | null | null | and are representative of three independent experiments. | false | true | true | true | false | 7,081 |
6 | DISCUSSION | 0 | null | null | 18,408,006 | null | *, p < 0.05 versus control (Student's t test). | null | 46 | 41,099 | 0 | false | null | null | *, p < 0.05 versus control (Student's t test). | false | false | true | true | false | 7,081 |
7 | DISCUSSION | 1 | 34 | [
"ref34",
"ref34",
"ref36",
"ref37",
"ref38"
] | 18,408,006 | pmid-17646733|pmid-17646733|pmid-17332250|pmid-12871640|pmid-2478233 | The functional characterization of CLEC9A on primary cells was limited by its expression on extremely rare populations of peripheral blood leukocytes. | [
"34",
"34",
"36",
"37",
"38"
] | 150 | 41,100 | 0 | false | The functional characterization of CLEC9A on primary cells was limited by its expression on extremely rare populations of peripheral blood leukocytes. | [] | The functional characterization of CLEC9A on primary cells was limited by its expression on extremely rare populations of peripheral blood leukocytes. | true | true | true | true | true | 7,082 |
7 | DISCUSSION | 1 | 34 | [
"ref34",
"ref34",
"ref36",
"ref37",
"ref38"
] | 18,408,006 | pmid-17646733|pmid-17646733|pmid-17332250|pmid-12871640|pmid-2478233 | The receptor is predominantly expressed by BDCA3+ DCs, which represent less than 0.05% of PBMC (34). | [
"34",
"34",
"36",
"37",
"38"
] | 100 | 41,101 | 1 | false | The receptor is predominantly expressed by BDCA3+ DCs, which represent less than 0.05% of PBMC. | [
"34"
] | The receptor is predominantly expressed by BDCA3+ DCs, which represent less than 0.05% of PBMC. | true | true | true | true | true | 7,082 |
7 | DISCUSSION | 1 | 34 | [
"ref34",
"ref34",
"ref36",
"ref37",
"ref38"
] | 18,408,006 | pmid-17646733|pmid-17646733|pmid-17332250|pmid-12871640|pmid-2478233 | Very little is known about this cell type, but they are thought to be immature precursors of interstitial DCs, and were recently shown to express multiple Toll-like receptors (34–36). | [
"34",
"34",
"36",
"37",
"38"
] | 183 | 41,102 | 0 | false | Very little is known about this cell type, but they are thought to be immature precursors of interstitial DCs, and were recently shown to express multiple Toll-like receptors. | [
"34–36"
] | Very little is known about this cell type, but they are thought to be immature precursors of interstitial DCs, and were recently shown to express multiple Toll-like receptors. | true | true | true | true | true | 7,082 |
7 | DISCUSSION | 1 | 34 | [
"ref34",
"ref34",
"ref36",
"ref37",
"ref38"
] | 18,408,006 | pmid-17646733|pmid-17646733|pmid-17332250|pmid-12871640|pmid-2478233 | CLEC9A is also expressed on small subsets of CD14+CD16- monocytes and on CD64+CD11b+ CD14- cells we were unable to identify further. | [
"34",
"34",
"36",
"37",
"38"
] | 132 | 41,103 | 0 | false | CLEC9A is also expressed on small subsets of CD14+CD16- monocytes and on CD64+CD11b+ CD14- cells we were unable to identify further. | [] | CLEC9A is also expressed on small subsets of CD14+CD16- monocytes and on CD64+CD11b+ CD14- cells we were unable to identify further. | true | true | true | true | true | 7,082 |
7 | DISCUSSION | 1 | 34 | [
"ref34",
"ref34",
"ref36",
"ref37",
"ref38"
] | 18,408,006 | pmid-17646733|pmid-17646733|pmid-17332250|pmid-12871640|pmid-2478233 | CD14+CD16- monocytes, the so called “inflammatory monocytes,” normally constitute around 14% of the PBMC and are thought to migrate to sites of inflammation where they can differentiate into dendritic cells (37, 38). | [
"34",
"34",
"36",
"37",
"38"
] | 216 | 41,104 | 0 | false | CD14+CD16- monocytes, the so called “inflammatory monocytes,” normally constitute around 14% of the PBMC and are thought to migrate to sites of inflammation where they can differentiate into dendritic cells. | [
"37, 38"
] | CD14+CD16- monocytes, the so called “inflammatory monocytes,” normally constitute around 14% of the PBMC and are thought to migrate to sites of inflammation where they can differentiate into dendritic cells. | true | true | true | true | true | 7,082 |
7 | DISCUSSION | 1 | 34 | [
"ref34",
"ref34",
"ref36",
"ref37",
"ref38"
] | 18,408,006 | pmid-17646733|pmid-17646733|pmid-17332250|pmid-12871640|pmid-2478233 | The expression of CLEC9A on a minor subset of these cells is suggestive of further differentiation of this monocyte population, and this receptor could potentially be used as a marker to characterize this subset in future analyses. | [
"34",
"34",
"36",
"37",
"38"
] | 231 | 41,105 | 0 | false | The expression of CLEC9A on a minor subset of these cells is suggestive of further differentiation of this monocyte population, and this receptor could potentially be used as a marker to characterize this subset in future analyses. | [] | The expression of CLEC9A on a minor subset of these cells is suggestive of further differentiation of this monocyte population, and this receptor could potentially be used as a marker to characterize this subset in future analyses. | true | true | true | true | true | 7,082 |
8 | DISCUSSION | 1 | 39 | [
"ref39"
] | 18,408,006 | pmid-16887988 | Although the ligand and physiological role of CLEC9A is unknown, its limited expression on peripheral blood leukocytes suggests that it is unlikely to function as a pattern recognition receptor. | [
"39"
] | 194 | 41,106 | 0 | false | Although the ligand and physiological role of CLEC9A is unknown, its limited expression on peripheral blood leukocytes suggests that it is unlikely to function as a pattern recognition receptor. | [] | Although the ligand and physiological role of CLEC9A is unknown, its limited expression on peripheral blood leukocytes suggests that it is unlikely to function as a pattern recognition receptor. | true | true | true | true | true | 7,083 |
8 | DISCUSSION | 1 | 39 | [
"ref39"
] | 18,408,006 | pmid-16887988 | However, the high levels of expression in the thymus and spleen, as determined by RT-PCR analysis (Fig. | [
"39"
] | 103 | 41,107 | 0 | false | However, the high levels of expression in the thymus and spleen, as determined by RT-PCR analysis (Fig. | [] | However, the high levels of expression in the thymus and spleen, as determined by RT-PCR analysis (Fig. | true | true | true | true | true | 7,083 |
8 | DISCUSSION | 1 | 39 | [
"ref39"
] | 18,408,006 | pmid-16887988 | 2), are suggestive of a role in immunity. | [
"39"
] | 41 | 41,108 | 0 | false | 2), are suggestive of a role in immunity. | [] | 2), are suggestive of a role in immunity. | false | false | true | true | false | 7,083 |
8 | DISCUSSION | 1 | 39 | [
"ref39"
] | 18,408,006 | pmid-16887988 | Furthermore, as an endocytic receptor, CLEC9A may facilitate antigen uptake and presentation, and may provide a suitable target for antibody-mediated antigen delivery, as has been demonstrated for a variety of other C-type lectins, including Dectin-1 (39). | [
"39"
] | 256 | 41,109 | 1 | false | Furthermore, as an endocytic receptor, CLEC9A may facilitate antigen uptake and presentation, and may provide a suitable target for antibody-mediated antigen delivery, as has been demonstrated for a variety of other C-type lectins, including Dectin-1. | [
"39"
] | Furthermore, as an endocytic receptor, CLEC9A may facilitate antigen uptake and presentation, and may provide a suitable target for antibody-mediated antigen delivery, as has been demonstrated for a variety of other C-type lectins, including Dectin-1. | true | true | true | true | true | 7,083 |
9 | DISCUSSION | 1 | 20 | [
"ref20"
] | 18,408,006 | pmid-16492762 | Despite being conserved between species (20), the murine CLEC9A orthologue appears to be structurally dissimilar to human CLEC9A. | [
"20"
] | 129 | 41,110 | 1 | false | Despite being conserved between species, the murine CLEC9A orthologue appears to be structurally dissimilar to human CLEC9A. | [
"20"
] | Despite being conserved between species, the murine CLEC9A orthologue appears to be structurally dissimilar to human CLEC9A. | true | true | true | true | true | 7,084 |
9 | DISCUSSION | 1 | 20 | [
"ref20"
] | 18,408,006 | pmid-16492762 | Murine, but not human, receptor is alternatively spliced into a number isoforms. | [
"20"
] | 80 | 41,111 | 0 | false | Murine, but not human, receptor is alternatively spliced into a number isoforms. | [] | Murine, but not human, receptor is alternatively spliced into a number isoforms. | true | true | true | true | true | 7,084 |
9 | DISCUSSION | 1 | 20 | [
"ref20"
] | 18,408,006 | pmid-16492762 | Furthermore, murine CLEC9A is not glycosylated nor does the receptor dimerize. | [
"20"
] | 78 | 41,112 | 0 | false | Furthermore, murine CLEC9A is not glycosylated nor does the receptor dimerize. | [] | Furthermore, murine CLEC9A is not glycosylated nor does the receptor dimerize. | true | true | true | true | true | 7,084 |
9 | DISCUSSION | 1 | 20 | [
"ref20"
] | 18,408,006 | pmid-16492762 | While the significance of these differences is unclear, they may reflect some degree of functional divergence of this molecule between the various species. | [
"20"
] | 155 | 41,113 | 0 | false | While the significance of these differences is unclear, they may reflect some degree of functional divergence of this molecule between the various species. | [] | While the significance of these differences is unclear, they may reflect some degree of functional divergence of this molecule between the various species. | true | true | true | true | true | 7,084 |
9 | DISCUSSION | 1 | 20 | [
"ref20"
] | 18,408,006 | pmid-16492762 | However, given the rarity of cells expressing this receptor in human blood, it may still be practical for further study of this receptor to be performed in mice. | [
"20"
] | 161 | 41,114 | 0 | false | However, given the rarity of cells expressing this receptor in human blood, it may still be practical for further study of this receptor to be performed in mice. | [] | However, given the rarity of cells expressing this receptor in human blood, it may still be practical for further study of this receptor to be performed in mice. | true | true | true | true | true | 7,084 |
0 | DISCUSSION | 0 | null | null | 18,701,462 | null | In the present study, we have identified and functionally characterized a
new dimerization domain in the N-terminal cytosolic region of PC2. | null | 141 | 41,115 | 0 | false | null | null | In the present study, we have identified and functionally characterized a
new dimerization domain in the N-terminal cytosolic region of PC2. | true | true | true | true | true | 7,085 |
0 | DISCUSSION | 0 | null | null | 18,701,462 | null | This domain
is shown to have a physiologically relevant role in zebrafish development as
it phenocopied known loss-of-function constructs of PC2. | null | 147 | 41,116 | 0 | false | null | null | This domain
is shown to have a physiologically relevant role in zebrafish development as
it phenocopied known loss-of-function constructs of PC2. | true | true | true | true | true | 7,085 |
0 | DISCUSSION | 0 | null | null | 18,701,462 | null | We propose that the
identification of this domain has important implications in type 2 ADPKD
pathophysiology. | null | 111 | 41,117 | 0 | false | null | null | We propose that the
identification of this domain has important implications in type 2 ADPKD
pathophysiology. | true | true | true | true | true | 7,085 |
1 | DISCUSSION | 1 | 27 | [
"ref27"
] | 18,701,462 | pmid-16943309 | The tendency of native PC2 to oligomerize led us initially to investigate
how PC2 homodimerization could be regulated. | [
"27"
] | 119 | 41,118 | 0 | false | The tendency of native PC2 to oligomerize led us initially to investigate how PC2 homodimerization could be regulated. | [] | The tendency of native PC2 to oligomerize led us initially to investigate how PC2 homodimerization could be regulated. | true | true | true | true | true | 7,086 |
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