paragraph_index int64 | sec string | p_has_citation int64 | cites string | citeids list | pmid int64 | cited_id string | sentences string | all_sent_cites list | sent_len int64 | sentence_batch_index int64 | sent_has_citation float64 | qc_fail bool | cited_sentence string | cites_in_sentence list | cln_sentence string | is_cap bool | is_alpha bool | ends_wp bool | cit_qc bool | lgtm bool | __index_level_0__ int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | DISCUSSION | 1 | Rasala | [
"B114",
"B65",
"B117",
"B1",
"B2"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA | Importantly, the sensitivity of channel formation to LPC that we see and its reversibility by OA or PE are consistent with a model where a hemifusion intermediate occurs between the outer and inner nuclear membranes during NPC assembly. | [
"Rasala ",
"Hetzer and Wente, 2009",
"Rotem ",
"Anderson and Hetzer, 2007",
"Antonin "
] | 236 | 41,419 | 0 | false | Importantly, the sensitivity of channel formation to LPC that we see and its reversibility by OA or PE are consistent with a model where a hemifusion intermediate occurs between the outer and inner nuclear membranes during NPC assembly. | [] | Importantly, the sensitivity of channel formation to LPC that we see and its reversibility by OA or PE are consistent with a model where a hemifusion intermediate occurs between the outer and inner nuclear membranes during NPC assembly. | true | true | true | true | true | 7,142 |
1 | DISCUSSION | 1 | Rasala | [
"B114",
"B65",
"B117",
"B1",
"B2"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA | These data argue against an alternate model which proposes that the bulk of the nuclear pore is assembled on the surface of chromatin and acquires membranes by being surrounded by expanding ER tubules and cisternae (reviewed in Anderson and Hetzer, 2007; Antonin et al., 2008). | [
"Rasala ",
"Hetzer and Wente, 2009",
"Rotem ",
"Anderson and Hetzer, 2007",
"Antonin "
] | 277 | 41,420 | 0 | false | These data argue against an alternate model which proposes that the bulk of the nuclear pore is assembled on the surface of chromatin and acquires membranes by being surrounded by expanding ER tubules and cisternae. | [
"reviewed in Anderson and Hetzer, 2007; Antonin et al., 2008"
] | These data argue against an alternate model which proposes that the bulk of the nuclear pore is assembled on the surface of chromatin and acquires membranes by being surrounded by expanding ER tubules and cisternae. | true | true | true | true | true | 7,142 |
2 | DISCUSSION | 1 | Rasala | [
"B113",
"B46",
"B52",
"B114",
"B82",
"B117",
"B114",
"B37",
"B114"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | The field is beginning to have an increasingly detailed view of the very early steps in postmitotic nuclear pore assembly. | [
"Rasala ",
"Franz ",
"Gillespie ",
"Rasala ",
"Lau ",
"Rotem ",
"Rasala ",
"Doucet ",
"Rasala "
] | 122 | 41,421 | 0 | false | The field is beginning to have an increasingly detailed view of the very early steps in postmitotic nuclear pore assembly. | [] | The field is beginning to have an increasingly detailed view of the very early steps in postmitotic nuclear pore assembly. | true | true | true | true | true | 7,143 |
2 | DISCUSSION | 1 | Rasala | [
"B113",
"B46",
"B52",
"B114",
"B82",
"B117",
"B114",
"B37",
"B114"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Specifically, the protein ELYS/MEL-28 acts by binding to chromatin via an AT-hook and at least one additional chromatin-binding domain. | [
"Rasala ",
"Franz ",
"Gillespie ",
"Rasala ",
"Lau ",
"Rotem ",
"Rasala ",
"Doucet ",
"Rasala "
] | 135 | 41,422 | 0 | false | Specifically, the protein ELYS/MEL-28 acts by binding to chromatin via an AT-hook and at least one additional chromatin-binding domain. | [] | Specifically, the protein ELYS/MEL-28 acts by binding to chromatin via an AT-hook and at least one additional chromatin-binding domain. | true | true | true | true | true | 7,143 |
2 | DISCUSSION | 1 | Rasala | [
"B113",
"B46",
"B52",
"B114",
"B82",
"B117",
"B114",
"B37",
"B114"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | ELYS either recruits the Nup107-160 complex to chromatin or is recruited in a joint complex with it to initiate pore assembly (Rasala et al., 2006; Franz et al., 2007; Gillespie et al., 2007; Rasala et al., 2008; Lau et al., 2009; Rotem et al., 2009). | [
"Rasala ",
"Franz ",
"Gillespie ",
"Rasala ",
"Lau ",
"Rotem ",
"Rasala ",
"Doucet ",
"Rasala "
] | 251 | 41,423 | 0 | false | ELYS either recruits the Nup107-160 complex to chromatin or is recruited in a joint complex with it to initiate pore assembly. | [
"Rasala et al., 2006; Franz et al., 2007; Gillespie et al., 2007; Rasala et al., 2008; Lau et al., 2009; Rotem et al., 2009"
] | ELYS either recruits the Nup107-160 complex to chromatin or is recruited in a joint complex with it to initiate pore assembly. | true | true | true | true | true | 7,143 |
2 | DISCUSSION | 1 | Rasala | [
"B113",
"B46",
"B52",
"B114",
"B82",
"B117",
"B114",
"B37",
"B114"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | In the absence of these proteins, the NPC integral membrane proteins POM121 and Ndc1 are not recruited to the nuclear membrane (Rasala et al., 2008). | [
"Rasala ",
"Franz ",
"Gillespie ",
"Rasala ",
"Lau ",
"Rotem ",
"Rasala ",
"Doucet ",
"Rasala "
] | 149 | 41,424 | 0 | false | In the absence of these proteins, the NPC integral membrane proteins POM121 and Ndc1 are not recruited to the nuclear membrane. | [
"Rasala et al., 2008"
] | In the absence of these proteins, the NPC integral membrane proteins POM121 and Ndc1 are not recruited to the nuclear membrane. | true | true | true | true | true | 7,143 |
2 | DISCUSSION | 1 | Rasala | [
"B113",
"B46",
"B52",
"B114",
"B82",
"B117",
"B114",
"B37",
"B114"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | A recent study by (Doucet et al., 2010) used RNAi to partially knock down ELYS or POM121 in HeLa cells. | [
"Rasala ",
"Franz ",
"Gillespie ",
"Rasala ",
"Lau ",
"Rotem ",
"Rasala ",
"Doucet ",
"Rasala "
] | 103 | 41,425 | 0 | false | A recent study by used RNAi to partially knock down ELYS or POM121 in HeLa cells. | [
"Doucet et al., 2010"
] | A recent study by used RNAi to partially knock down ELYS or POM121 in HeLa cells. | true | true | true | true | true | 7,143 |
2 | DISCUSSION | 1 | Rasala | [
"B113",
"B46",
"B52",
"B114",
"B82",
"B117",
"B114",
"B37",
"B114"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | They concluded that these two proteins are differentially rate-limiting in interphase and mitotic pore assembly. | [
"Rasala ",
"Franz ",
"Gillespie ",
"Rasala ",
"Lau ",
"Rotem ",
"Rasala ",
"Doucet ",
"Rasala "
] | 112 | 41,426 | 0 | false | They concluded that these two proteins are differentially rate-limiting in interphase and mitotic pore assembly. | [] | They concluded that these two proteins are differentially rate-limiting in interphase and mitotic pore assembly. | true | true | true | true | true | 7,143 |
2 | DISCUSSION | 1 | Rasala | [
"B113",
"B46",
"B52",
"B114",
"B82",
"B117",
"B114",
"B37",
"B114"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Their results are consistent with our biochemical demonstration that POM121 can bind and pull down the Nup107/160 complex from Xenopus egg extracts (Rasala et al., 2008) as well as with the findings here where POM121 and the Nup107/160 complex colocalize on the inner nuclear membrane in a very early step in post-mitoti... | [
"Rasala ",
"Franz ",
"Gillespie ",
"Rasala ",
"Lau ",
"Rotem ",
"Rasala ",
"Doucet ",
"Rasala "
] | 344 | 41,427 | 0 | false | Their results are consistent with our biochemical demonstration that POM121 can bind and pull down the Nup107/160 complex from Xenopus egg extracts as well as with the findings here where POM121 and the Nup107/160 complex colocalize on the inner nuclear membrane in a very early step in post-mitotic nuclear pore assembl... | [
"Rasala et al., 2008"
] | Their results are consistent with our biochemical demonstration that POM121 can bind and pull down the Nup107/160 complex from Xenopus egg extracts as well as with the findings here where POM121 and the Nup107/160 complex colocalize on the inner nuclear membrane in a very early step in post-mitotic nuclear pore assembl... | true | true | true | true | true | 7,143 |
3 | DISCUSSION | 1 | Bishop and Bell, 1985 | [
"B7",
"B63",
"B14",
"B95",
"B108",
"B19",
"B16"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Inner/outer nuclear membrane fusion has previously proven to be a difficult step to detect or analyze. | [
"Bishop and Bell, 1985",
"Herrmann ",
"Buton ",
"Marx ",
"Papadopulos ",
"Chernomordik ",
"Chernomordik "
] | 102 | 41,428 | 0 | false | Inner/outer nuclear membrane fusion has previously proven to be a difficult step to detect or analyze. | [] | Inner/outer nuclear membrane fusion has previously proven to be a difficult step to detect or analyze. | true | true | true | true | true | 7,144 |
3 | DISCUSSION | 1 | Bishop and Bell, 1985 | [
"B7",
"B63",
"B14",
"B95",
"B108",
"B19",
"B16"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Assembly of nuclear pores in existing nuclear membranes, such as yeast nuclei or S-phase vertebrate nuclei in vivo, must by definition involve interaction between the lumenal leaflets of the inner and outer nuclear membranes. | [
"Bishop and Bell, 1985",
"Herrmann ",
"Buton ",
"Marx ",
"Papadopulos ",
"Chernomordik ",
"Chernomordik "
] | 225 | 41,429 | 0 | false | Assembly of nuclear pores in existing nuclear membranes, such as yeast nuclei or S-phase vertebrate nuclei in vivo, must by definition involve interaction between the lumenal leaflets of the inner and outer nuclear membranes. | [] | Assembly of nuclear pores in existing nuclear membranes, such as yeast nuclei or S-phase vertebrate nuclei in vivo, must by definition involve interaction between the lumenal leaflets of the inner and outer nuclear membranes. | true | true | true | true | true | 7,144 |
3 | DISCUSSION | 1 | Bishop and Bell, 1985 | [
"B7",
"B63",
"B14",
"B95",
"B108",
"B19",
"B16"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | There hemifusion would precede full fusion and thus would be predicted to be sensitive to arrest by the membrane fusion-inhibiting lipids LPC and OA. | [
"Bishop and Bell, 1985",
"Herrmann ",
"Buton ",
"Marx ",
"Papadopulos ",
"Chernomordik ",
"Chernomordik "
] | 149 | 41,430 | 0 | false | There hemifusion would precede full fusion and thus would be predicted to be sensitive to arrest by the membrane fusion-inhibiting lipids LPC and OA. | [] | There hemifusion would precede full fusion and thus would be predicted to be sensitive to arrest by the membrane fusion-inhibiting lipids LPC and OA. | true | true | true | true | true | 7,144 |
3 | DISCUSSION | 1 | Bishop and Bell, 1985 | [
"B7",
"B63",
"B14",
"B95",
"B108",
"B19",
"B16"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | In our in vitro nuclear assembly system, we could only add LPC or OA to the outer leaflet of the outer nuclear membrane of a cold intermediate, which is actually the leaflet facing away from the potential fusion event. | [
"Bishop and Bell, 1985",
"Herrmann ",
"Buton ",
"Marx ",
"Papadopulos ",
"Chernomordik ",
"Chernomordik "
] | 218 | 41,431 | 0 | false | In our in vitro nuclear assembly system, we could only add LPC or OA to the outer leaflet of the outer nuclear membrane of a cold intermediate, which is actually the leaflet facing away from the potential fusion event. | [] | In our in vitro nuclear assembly system, we could only add LPC or OA to the outer leaflet of the outer nuclear membrane of a cold intermediate, which is actually the leaflet facing away from the potential fusion event. | true | true | true | true | true | 7,144 |
3 | DISCUSSION | 1 | Bishop and Bell, 1985 | [
"B7",
"B63",
"B14",
"B95",
"B108",
"B19",
"B16"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | However, multiple reports have shown that rapid interleaflet exchange of phospholipids occurs in ER-derived membranes via resident lipid flippases (Bishop and Bell, 1985; Herrmann et al., 1990; Buton et al., 1996; Marx et al., 2000; Papadopulos et al., 2007). | [
"Bishop and Bell, 1985",
"Herrmann ",
"Buton ",
"Marx ",
"Papadopulos ",
"Chernomordik ",
"Chernomordik "
] | 259 | 41,432 | 0 | false | However, multiple reports have shown that rapid interleaflet exchange of phospholipids occurs in ER-derived membranes via resident lipid flippases. | [
"Bishop and Bell, 1985; Herrmann et al., 1990; Buton et al., 1996; Marx et al., 2000; Papadopulos et al., 2007"
] | However, multiple reports have shown that rapid interleaflet exchange of phospholipids occurs in ER-derived membranes via resident lipid flippases. | true | true | true | true | true | 7,144 |
3 | DISCUSSION | 1 | Bishop and Bell, 1985 | [
"B7",
"B63",
"B14",
"B95",
"B108",
"B19",
"B16"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Thus, when LPC or OA was added to our cold intermediate, it should quickly equilibrate between the leaflets of the outer nuclear membrane. | [
"Bishop and Bell, 1985",
"Herrmann ",
"Buton ",
"Marx ",
"Papadopulos ",
"Chernomordik ",
"Chernomordik "
] | 138 | 41,433 | 0 | false | Thus, when LPC or OA was added to our cold intermediate, it should quickly equilibrate between the leaflets of the outer nuclear membrane. | [] | Thus, when LPC or OA was added to our cold intermediate, it should quickly equilibrate between the leaflets of the outer nuclear membrane. | true | true | true | true | true | 7,144 |
3 | DISCUSSION | 1 | Bishop and Bell, 1985 | [
"B7",
"B63",
"B14",
"B95",
"B108",
"B19",
"B16"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | The presence of LPC in only one of two fusing bilayers has been shown to be sufficient to block fusion (Chernomordik et al., 1997; | [
"Bishop and Bell, 1985",
"Herrmann ",
"Buton ",
"Marx ",
"Papadopulos ",
"Chernomordik ",
"Chernomordik "
] | 130 | 41,434 | 0 | false | The presence of LPC in only one of two fusing bilayers has been shown to be sufficient to block fusion (Chernomordik et al., 1997; | [] | The presence of LPC in only one of two fusing bilayers has been shown to be sufficient to block fusion (Chernomordik et al., 1997; | true | true | false | true | false | 7,144 |
3 | DISCUSSION | 1 | Bishop and Bell, 1985 | [
"B7",
"B63",
"B14",
"B95",
"B108",
"B19",
"B16"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Chernomordik et al., 1998). | [
"Bishop and Bell, 1985",
"Herrmann ",
"Buton ",
"Marx ",
"Papadopulos ",
"Chernomordik ",
"Chernomordik "
] | 27 | 41,435 | 0 | false | Chernomordik et al., 1998). | [] | Chernomordik et al., 1998). | true | true | true | true | true | 7,144 |
3 | DISCUSSION | 1 | Bishop and Bell, 1985 | [
"B7",
"B63",
"B14",
"B95",
"B108",
"B19",
"B16"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Indeed, we observed that LPC prevented 3-kDa channel formation and FG nucleoporin recruitment in the cold intermediate. | [
"Bishop and Bell, 1985",
"Herrmann ",
"Buton ",
"Marx ",
"Papadopulos ",
"Chernomordik ",
"Chernomordik "
] | 119 | 41,436 | 0 | false | Indeed, we observed that LPC prevented 3-kDa channel formation and FG nucleoporin recruitment in the cold intermediate. | [] | Indeed, we observed that LPC prevented 3-kDa channel formation and FG nucleoporin recruitment in the cold intermediate. | true | true | true | true | true | 7,144 |
3 | DISCUSSION | 1 | Bishop and Bell, 1985 | [
"B7",
"B63",
"B14",
"B95",
"B108",
"B19",
"B16"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | OA treatment also inhibited FG nucleoporin recruitment in this intermediate, but when added together, the two lipids counteracted one another and diffusion channel formation and FG recruitment proceeded, fulfilling the prediction above. | [
"Bishop and Bell, 1985",
"Herrmann ",
"Buton ",
"Marx ",
"Papadopulos ",
"Chernomordik ",
"Chernomordik "
] | 236 | 41,437 | 0 | false | OA treatment also inhibited FG nucleoporin recruitment in this intermediate, but when added together, the two lipids counteracted one another and diffusion channel formation and FG recruitment proceeded, fulfilling the prediction above. | [] | OA treatment also inhibited FG nucleoporin recruitment in this intermediate, but when added together, the two lipids counteracted one another and diffusion channel formation and FG recruitment proceeded, fulfilling the prediction above. | true | true | true | true | true | 7,144 |
3 | DISCUSSION | 1 | Bishop and Bell, 1985 | [
"B7",
"B63",
"B14",
"B95",
"B108",
"B19",
"B16"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Thus, our data strongly argue that LPC and OA are acting to prevent inner/outer nuclear membrane fusion. | [
"Bishop and Bell, 1985",
"Herrmann ",
"Buton ",
"Marx ",
"Papadopulos ",
"Chernomordik ",
"Chernomordik "
] | 104 | 41,438 | 0 | false | Thus, our data strongly argue that LPC and OA are acting to prevent inner/outer nuclear membrane fusion. | [] | Thus, our data strongly argue that LPC and OA are acting to prevent inner/outer nuclear membrane fusion. | true | true | true | true | true | 7,144 |
4 | DISCUSSION | 0 | null | null | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA | Is there a way in which cold, LPC, or OA could be blocking NPC assembly other than by blocking fusion? | null | 102 | 41,439 | 0 | false | null | null | Is there a way in which cold, LPC, or OA could be blocking NPC assembly other than by blocking fusion? | true | true | true | true | true | 7,145 |
4 | DISCUSSION | 0 | null | null | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA | One speculative model might be that, normally, inner/outer nuclear membrane fusion occurs but results in formation of a tightly “closed” membranous tube that is so narrow as to be impermeable to 3-kDa dextrans. | null | 210 | 41,440 | 0 | false | null | null | One speculative model might be that, normally, inner/outer nuclear membrane fusion occurs but results in formation of a tightly “closed” membranous tube that is so narrow as to be impermeable to 3-kDa dextrans. | true | true | true | true | true | 7,145 |
4 | DISCUSSION | 0 | null | null | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA | Cold, LPC, or OA could then all possibly act by inhibiting the postfusion dilation of such a tube. | null | 98 | 41,441 | 0 | false | null | null | Cold, LPC, or OA could then all possibly act by inhibiting the postfusion dilation of such a tube. | true | true | true | true | true | 7,145 |
4 | DISCUSSION | 0 | null | null | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA | We think this unlikely, especially in light of their established role as fusion inhibitors in other studies. | null | 108 | 41,442 | 0 | false | null | null | We think this unlikely, especially in light of their established role as fusion inhibitors in other studies. | true | true | true | true | true | 7,145 |
4 | DISCUSSION | 0 | null | null | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA | However, if true, this alternative model would still be consistent with our conclusion that correct channel formation is blocked by the inhibitor LPC and reversed by addition of its counteracting lipid OA. | null | 205 | 41,443 | 0 | false | null | null | However, if true, this alternative model would still be consistent with our conclusion that correct channel formation is blocked by the inhibitor LPC and reversed by addition of its counteracting lipid OA. | true | true | true | true | true | 7,145 |
5 | DISCUSSION | 1 | Cohen | [
"B24",
"B26",
"B59",
"B83",
"B51",
"B137",
"B55",
"B59",
"B25",
"B38",
"B86",
"B42",
"B105",
"B3",
"B83",
"B93",
"B127"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | For inner/outer membrane fusion, a fusion machinery must of necessity bring the two membranes into close proximity. | [
"Cohen ",
"Crisp and Burke, 2008",
"Hallberg ",
"Lau ",
"Gerace ",
"Wozniak ",
"Greber ",
"Hallberg ",
"Cotter ",
"Drummond and Wilson, 2002",
"Liu ",
"Eriksson ",
"Olsson ",
"Antonin ",
"Lau ",
"Mansfeld ",
"Stavru "
] | 115 | 41,444 | 0 | false | For inner/outer membrane fusion, a fusion machinery must of necessity bring the two membranes into close proximity. | [] | For inner/outer membrane fusion, a fusion machinery must of necessity bring the two membranes into close proximity. | true | true | true | true | true | 7,146 |
5 | DISCUSSION | 1 | Cohen | [
"B24",
"B26",
"B59",
"B83",
"B51",
"B137",
"B55",
"B59",
"B25",
"B38",
"B86",
"B42",
"B105",
"B3",
"B83",
"B93",
"B127"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | In structural terms, the 30–50 nm space (20–40 nm in yeast) must be bridged (Cohen et al., 2002; Crisp and Burke, 2008). | [
"Cohen ",
"Crisp and Burke, 2008",
"Hallberg ",
"Lau ",
"Gerace ",
"Wozniak ",
"Greber ",
"Hallberg ",
"Cotter ",
"Drummond and Wilson, 2002",
"Liu ",
"Eriksson ",
"Olsson ",
"Antonin ",
"Lau ",
"Mansfeld ",
"Stavru "
] | 120 | 41,445 | 0 | false | In structural terms, the 30–50 nm space (20–40 nm in yeast) must be bridged. | [
"Cohen et al., 2002; Crisp and Burke, 2008"
] | In structural terms, the 30–50 nm space must be bridged. | true | true | true | true | true | 7,146 |
5 | DISCUSSION | 1 | Cohen | [
"B24",
"B26",
"B59",
"B83",
"B51",
"B137",
"B55",
"B59",
"B25",
"B38",
"B86",
"B42",
"B105",
"B3",
"B83",
"B93",
"B127"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Of the three human integral membrane nucleoporins, POM121, Ndc1, and gp210, the first two have a very small lumenal presence (33–39 aa and 21–30 aa) (Hallberg et al., 1993; Lau et al., 2006). | [
"Cohen ",
"Crisp and Burke, 2008",
"Hallberg ",
"Lau ",
"Gerace ",
"Wozniak ",
"Greber ",
"Hallberg ",
"Cotter ",
"Drummond and Wilson, 2002",
"Liu ",
"Eriksson ",
"Olsson ",
"Antonin ",
"Lau ",
"Mansfeld ",
"Stavru "
] | 191 | 41,446 | 0 | false | Of the three human integral membrane nucleoporins, POM121, Ndc1, and gp210, the first two have a very small lumenal presence (33–39 aa and 21–30 aa). | [
"Hallberg et al., 1993; Lau et al., 2006"
] | Of the three human integral membrane nucleoporins, POM121, Ndc1, and gp210, the first two have a very small lumenal presence. | true | true | true | true | true | 7,146 |
5 | DISCUSSION | 1 | Cohen | [
"B24",
"B26",
"B59",
"B83",
"B51",
"B137",
"B55",
"B59",
"B25",
"B38",
"B86",
"B42",
"B105",
"B3",
"B83",
"B93",
"B127"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Gp210 has a large lumenal domain (1782 aa) (Gerace et al., 1982), but has been found to be dispensable in some studies, both by RNAi depletion and in certain cells that naturally lack gp210 (Wozniak et al., 1989; Greber et al., 1990; Hallberg et al., 1993; Cotter et al., 1998; Drummond and Wilson, 2002; Liu et al., 200... | [
"Cohen ",
"Crisp and Burke, 2008",
"Hallberg ",
"Lau ",
"Gerace ",
"Wozniak ",
"Greber ",
"Hallberg ",
"Cotter ",
"Drummond and Wilson, 2002",
"Liu ",
"Eriksson ",
"Olsson ",
"Antonin ",
"Lau ",
"Mansfeld ",
"Stavru "
] | 452 | 41,447 | 0 | false | Gp210 has a large lumenal domain (1782 aa), but has been found to be dispensable in some studies, both by RNAi depletion and in certain cells that naturally lack gp210. | [
"Gerace et al., 1982",
"Wozniak et al., 1989; Greber et al., 1990; Hallberg et al., 1993; Cotter et al., 1998; Drummond and Wilson, 2002; Liu et al., 2003; Eriksson et al., 2004; Olsson et al., 2004; Antonin et al., 2005; Lau et al., 2006; Mansfeld et al., 2006; Stavru et al., 2006a"
] | Gp210 has a large lumenal domain, but has been found to be dispensable in some studies, both by RNAi depletion and in certain cells that naturally lack gp210. | true | true | true | true | true | 7,146 |
5 | DISCUSSION | 1 | Cohen | [
"B24",
"B26",
"B59",
"B83",
"B51",
"B137",
"B55",
"B59",
"B25",
"B38",
"B86",
"B42",
"B105",
"B3",
"B83",
"B93",
"B127"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Thus, neither Pom121, Ndc1, nor gp210 appears on its own to fill the requirements for bridging the lumenal gap needed for inner/outer membrane fusion. | [
"Cohen ",
"Crisp and Burke, 2008",
"Hallberg ",
"Lau ",
"Gerace ",
"Wozniak ",
"Greber ",
"Hallberg ",
"Cotter ",
"Drummond and Wilson, 2002",
"Liu ",
"Eriksson ",
"Olsson ",
"Antonin ",
"Lau ",
"Mansfeld ",
"Stavru "
] | 150 | 41,448 | 0 | false | Thus, neither Pom121, Ndc1, nor gp210 appears on its own to fill the requirements for bridging the lumenal gap needed for inner/outer membrane fusion. | [] | Thus, neither Pom121, Ndc1, nor gp210 appears on its own to fill the requirements for bridging the lumenal gap needed for inner/outer membrane fusion. | true | true | true | true | true | 7,146 |
6 | DISCUSSION | 1 | Fridkin | [
"B47",
"B69",
"B132",
"B130",
"B26",
"B13",
"B87"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | The inner nuclear membrane SUN proteins and outer nuclear membrane KASH proteins together form long proteinaceous tethers across the intermembrane space and theoretically could be the bridge (Fridkin et al., 2004; Holaska and Wilson, 2006; Tzur et al., 2006; Stewart et al., 2007; Crisp and Burke, 2008; Burke and Roux, ... | [
"Fridkin ",
"Holaska and Wilson, 2006",
"Tzur ",
"Stewart ",
"Crisp and Burke, 2008",
"Burke and Roux, 2009",
"Liu "
] | 326 | 41,449 | 0 | false | The inner nuclear membrane SUN proteins and outer nuclear membrane KASH proteins together form long proteinaceous tethers across the intermembrane space and theoretically could be the bridge. | [
"Fridkin et al., 2004; Holaska and Wilson, 2006; Tzur et al., 2006; Stewart et al., 2007; Crisp and Burke, 2008; Burke and Roux, 2009"
] | The inner nuclear membrane SUN proteins and outer nuclear membrane KASH proteins together form long proteinaceous tethers across the intermembrane space and theoretically could be the bridge. | true | true | true | true | true | 7,147 |
6 | DISCUSSION | 1 | Fridkin | [
"B47",
"B69",
"B132",
"B130",
"B26",
"B13",
"B87"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | No involvement in nuclear membrane fusion events, however, has been observed for these proteins, but Sun1 at least has been found to be associated with the nuclear pore in mammalian cells (Liu et al., 2007). | [
"Fridkin ",
"Holaska and Wilson, 2006",
"Tzur ",
"Stewart ",
"Crisp and Burke, 2008",
"Burke and Roux, 2009",
"Liu "
] | 207 | 41,450 | 0 | false | No involvement in nuclear membrane fusion events, however, has been observed for these proteins, but Sun1 at least has been found to be associated with the nuclear pore in mammalian cells. | [
"Liu et al., 2007"
] | No involvement in nuclear membrane fusion events, however, has been observed for these proteins, but Sun1 at least has been found to be associated with the nuclear pore in mammalian cells. | true | true | true | true | true | 7,147 |
7 | DISCUSSION | 1 | Voeltz | [
"B134",
"B70",
"B124",
"B30",
"B30",
"B121",
"B31",
"B126",
"B120",
"B68",
"B120"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | The reticulon and Yop1/DP1 protein families, involved in ER membrane-bending, play a role in nuclear pore assembly in yeast (Voeltz et al., 2006; Hu et al., 2008; Shibata et al., 2008; Dawson et al., 2009). | [
"Voeltz ",
"Hu ",
"Shibata ",
"Dawson ",
"Dawson ",
"Schneiter ",
"de Bruyn Kops and Guthrie, 2001",
"Sondermann ",
"Scarcelli ",
"Hodge ",
"Scarcelli "
] | 206 | 41,451 | 0 | false | The reticulon and Yop1/DP1 protein families, involved in ER membrane-bending, play a role in nuclear pore assembly in yeast. | [
"Voeltz et al., 2006; Hu et al., 2008; Shibata et al., 2008; Dawson et al., 2009"
] | The reticulon and Yop1/DP1 protein families, involved in ER membrane-bending, play a role in nuclear pore assembly in yeast. | true | true | true | true | true | 7,148 |
7 | DISCUSSION | 1 | Voeltz | [
"B134",
"B70",
"B124",
"B30",
"B30",
"B121",
"B31",
"B126",
"B120",
"B68",
"B120"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | In addition, in the Xenopus nuclear assembly system, antibodies to Reticulon-4a inhibit new pore assembly (Dawson et al., 2009). | [
"Voeltz ",
"Hu ",
"Shibata ",
"Dawson ",
"Dawson ",
"Schneiter ",
"de Bruyn Kops and Guthrie, 2001",
"Sondermann ",
"Scarcelli ",
"Hodge ",
"Scarcelli "
] | 128 | 41,452 | 0 | false | In addition, in the Xenopus nuclear assembly system, antibodies to Reticulon-4a inhibit new pore assembly. | [
"Dawson et al., 2009"
] | In addition, in the Xenopus nuclear assembly system, antibodies to Reticulon-4a inhibit new pore assembly. | true | true | true | true | true | 7,148 |
7 | DISCUSSION | 1 | Voeltz | [
"B134",
"B70",
"B124",
"B30",
"B30",
"B121",
"B31",
"B126",
"B120",
"B68",
"B120"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Other proteins of the yeast ER and/or nuclear membrane have also been observed to affect nuclear pores at some level, including Apq12, Brr6, Snl1, and Acc1 (Hodge et al.,; Schneiter et al., 1996; de Bruyn Kops and Guthrie, 2001; Sondermann et al., 2002; Scarcelli et al., 2007). | [
"Voeltz ",
"Hu ",
"Shibata ",
"Dawson ",
"Dawson ",
"Schneiter ",
"de Bruyn Kops and Guthrie, 2001",
"Sondermann ",
"Scarcelli ",
"Hodge ",
"Scarcelli "
] | 278 | 41,453 | 0 | false | Other proteins of the yeast ER and/or nuclear membrane have also been observed to affect nuclear pores at some level, including Apq12, Brr6, Snl1, and Acc1. | [
"Hodge et al.,; Schneiter et al., 1996; de Bruyn Kops and Guthrie, 2001; Sondermann et al., 2002; Scarcelli et al., 2007"
] | Other proteins of the yeast ER and/or nuclear membrane have also been observed to affect nuclear pores at some level, including Apq12, Brr6, Snl1, and Acc1. | true | true | true | true | true | 7,148 |
7 | DISCUSSION | 1 | Voeltz | [
"B134",
"B70",
"B124",
"B30",
"B30",
"B121",
"B31",
"B126",
"B120",
"B68",
"B120"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | Interestingly, Apq12 null yeast are cold sensitive for growth. | [
"Voeltz ",
"Hu ",
"Shibata ",
"Dawson ",
"Dawson ",
"Schneiter ",
"de Bruyn Kops and Guthrie, 2001",
"Sondermann ",
"Scarcelli ",
"Hodge ",
"Scarcelli "
] | 62 | 41,454 | 0 | false | Interestingly, Apq12 null yeast are cold sensitive for growth. | [] | Interestingly, Apq12 null yeast are cold sensitive for growth. | true | true | true | true | true | 7,148 |
7 | DISCUSSION | 1 | Voeltz | [
"B134",
"B70",
"B124",
"B30",
"B30",
"B121",
"B31",
"B126",
"B120",
"B68",
"B120"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | They and brr6-1 mutant cells appear to have electron dense NPC-like structures that are associated only with the inner nuclear membrane and not with the outer membrane (Hodge et al., 2010; Scarcelli et al., 2007). | [
"Voeltz ",
"Hu ",
"Shibata ",
"Dawson ",
"Dawson ",
"Schneiter ",
"de Bruyn Kops and Guthrie, 2001",
"Sondermann ",
"Scarcelli ",
"Hodge ",
"Scarcelli "
] | 213 | 41,455 | 0 | false | They and brr6-1 mutant cells appear to have electron dense NPC-like structures that are associated only with the inner nuclear membrane and not with the outer membrane. | [
"Hodge et al., 2010; Scarcelli et al., 2007"
] | They and brr6-1 mutant cells appear to have electron dense NPC-like structures that are associated only with the inner nuclear membrane and not with the outer membrane. | true | true | true | true | true | 7,148 |
7 | DISCUSSION | 1 | Voeltz | [
"B134",
"B70",
"B124",
"B30",
"B30",
"B121",
"B31",
"B126",
"B120",
"B68",
"B120"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | However, it is not yet known whether any of the above proteins have a connection to inner/outer membrane fusion. | [
"Voeltz ",
"Hu ",
"Shibata ",
"Dawson ",
"Dawson ",
"Schneiter ",
"de Bruyn Kops and Guthrie, 2001",
"Sondermann ",
"Scarcelli ",
"Hodge ",
"Scarcelli "
] | 112 | 41,456 | 0 | false | However, it is not yet known whether any of the above proteins have a connection to inner/outer membrane fusion. | [] | However, it is not yet known whether any of the above proteins have a connection to inner/outer membrane fusion. | true | true | true | true | true | 7,148 |
7 | DISCUSSION | 1 | Voeltz | [
"B134",
"B70",
"B124",
"B30",
"B30",
"B121",
"B31",
"B126",
"B120",
"B68",
"B120"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA | In summary, the fusion protein(s) for nuclear pore assembly await discovery. | [
"Voeltz ",
"Hu ",
"Shibata ",
"Dawson ",
"Dawson ",
"Schneiter ",
"de Bruyn Kops and Guthrie, 2001",
"Sondermann ",
"Scarcelli ",
"Hodge ",
"Scarcelli "
] | 76 | 41,457 | 0 | false | In summary, the fusion protein(s) for nuclear pore assembly await discovery. | [] | In summary, the fusion protein(s) for nuclear pore assembly await discovery. | true | true | true | true | true | 7,148 |
8 | DISCUSSION | 1 | Siniossoglou | [
"B125",
"B90",
"B5",
"B36",
"B33",
"B12",
"B12",
"B35",
"B106"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA | The next question, beyond the issue of what causes fusion, is how the fusion pore becomes limited in its expansion to ∼900 Å, the width of the actual membrane passage that connects the nuclear interior to the cytoplasm. | [
"Siniossoglou ",
"Lutzmann ",
"Beck ",
"Devos ",
"Debler ",
"Brohawn and Schwartz, 2009",
"Brohawn and Schwartz, 2009",
"DeGrasse ",
"Onischenko "
] | 219 | 41,458 | 0 | false | The next question, beyond the issue of what causes fusion, is how the fusion pore becomes limited in its expansion to ∼900 Å, the width of the actual membrane passage that connects the nuclear interior to the cytoplasm. | [] | The next question, beyond the issue of what causes fusion, is how the fusion pore becomes limited in its expansion to ∼900 Å, the width of the actual membrane passage that connects the nuclear interior to the cytoplasm. | true | true | true | true | true | 7,149 |
8 | DISCUSSION | 1 | Siniossoglou | [
"B125",
"B90",
"B5",
"B36",
"B33",
"B12",
"B12",
"B35",
"B106"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA | The Nup107-160 complex has a Y-shape (∼230 Å × ∼420 Å) and has been hypothesized to form a multimeric lattice that could line and stabilize this passageway (Siniossoglou et al., 2000; Lutzmann et al., 2002; Beck et al., 2004; Devos et al., 2004; Debler et al., 2008; Brohawn and Schwartz, 2009). | [
"Siniossoglou ",
"Lutzmann ",
"Beck ",
"Devos ",
"Debler ",
"Brohawn and Schwartz, 2009",
"Brohawn and Schwartz, 2009",
"DeGrasse ",
"Onischenko "
] | 295 | 41,459 | 0 | false | The Nup107-160 complex has a Y-shape (∼230 Å × ∼420 Å) and has been hypothesized to form a multimeric lattice that could line and stabilize this passageway. | [
"Siniossoglou et al., 2000; Lutzmann et al., 2002; Beck et al., 2004; Devos et al., 2004; Debler et al., 2008; Brohawn and Schwartz, 2009"
] | The Nup107-160 complex has a Y-shape and has been hypothesized to form a multimeric lattice that could line and stabilize this passageway. | true | true | true | true | true | 7,149 |
8 | DISCUSSION | 1 | Siniossoglou | [
"B125",
"B90",
"B5",
"B36",
"B33",
"B12",
"B12",
"B35",
"B106"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA | In strong support of such a lattice model, crystallographic analysis of the Nup96/sec13 and Nup85/seh1 proteins, components of the Nup107-160 complex, are closely related in 3D structures to the sec31/sec13 complex that forms the lattice-like coat of COP II transport vesicles (Brohawn and Schwartz, 2009; DeGrasse et al... | [
"Siniossoglou ",
"Lutzmann ",
"Beck ",
"Devos ",
"Debler ",
"Brohawn and Schwartz, 2009",
"Brohawn and Schwartz, 2009",
"DeGrasse ",
"Onischenko "
] | 329 | 41,460 | 0 | false | In strong support of such a lattice model, crystallographic analysis of the Nup96/sec13 and Nup85/seh1 proteins, components of the Nup107-160 complex, are closely related in 3D structures to the sec31/sec13 complex that forms the lattice-like coat of COP II transport vesicles. | [
"Brohawn and Schwartz, 2009; DeGrasse et al., 2009"
] | In strong support of such a lattice model, crystallographic analysis of the Nup96/sec13 and Nup85/seh1 proteins, components of the Nup107-160 complex, are closely related in 3D structures to the sec31/sec13 complex that forms the lattice-like coat of COP II transport vesicles. | true | true | true | true | true | 7,149 |
8 | DISCUSSION | 1 | Siniossoglou | [
"B125",
"B90",
"B5",
"B36",
"B33",
"B12",
"B12",
"B35",
"B106"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA | We would suggest that a ring of Nup107-160 complexes that is multimerized on the surface of the inner nuclear membrane and attached to the membrane by POM121 could act as a preset ring that limits fusion pore expansion. | [
"Siniossoglou ",
"Lutzmann ",
"Beck ",
"Devos ",
"Debler ",
"Brohawn and Schwartz, 2009",
"Brohawn and Schwartz, 2009",
"DeGrasse ",
"Onischenko "
] | 219 | 41,461 | 0 | false | We would suggest that a ring of Nup107-160 complexes that is multimerized on the surface of the inner nuclear membrane and attached to the membrane by POM121 could act as a preset ring that limits fusion pore expansion. | [] | We would suggest that a ring of Nup107-160 complexes that is multimerized on the surface of the inner nuclear membrane and attached to the membrane by POM121 could act as a preset ring that limits fusion pore expansion. | true | true | true | true | true | 7,149 |
8 | DISCUSSION | 1 | Siniossoglou | [
"B125",
"B90",
"B5",
"B36",
"B33",
"B12",
"B12",
"B35",
"B106"
] | 20,926,687 | NA|NA|NA|NA|NA|NA|NA|NA|NA | This Nup107-160 complex could also require other proteins for stabilization of the membrane channel, as in yeast the depletion of a subset of membrane nucleoporins (Ndc1, Pom152, and Pom34), together with Nup59 or Nup53 depletion, results in nuclear pores that are noticeably dilated (Onischenko et al., 2009). | [
"Siniossoglou ",
"Lutzmann ",
"Beck ",
"Devos ",
"Debler ",
"Brohawn and Schwartz, 2009",
"Brohawn and Schwartz, 2009",
"DeGrasse ",
"Onischenko "
] | 310 | 41,462 | 0 | false | This Nup107-160 complex could also require other proteins for stabilization of the membrane channel, as in yeast the depletion of a subset of membrane nucleoporins (Ndc1, Pom152, and Pom34), together with Nup59 or Nup53 depletion, results in nuclear pores that are noticeably dilated. | [
"Onischenko et al., 2009"
] | This Nup107-160 complex could also require other proteins for stabilization of the membrane channel, as in yeast the depletion of a subset of membrane nucleoporins, together with Nup59 or Nup53 depletion, results in nuclear pores that are noticeably dilated. | true | true | true | true | true | 7,149 |
9 | DISCUSSION | 1 | Huebner and Gutzeit, 1986 | [
"B71",
"B23",
"B98"
] | 20,926,687 | NA|NA|NA | Large membrane-lined channels connecting two entities are rare in evolution. | [
"Huebner and Gutzeit, 1986",
"Cilia and Jackson, 2004",
"Mische "
] | 76 | 41,463 | 0 | false | Large membrane-lined channels connecting two entities are rare in evolution. | [] | Large membrane-lined channels connecting two entities are rare in evolution. | true | true | true | true | true | 7,150 |
9 | DISCUSSION | 1 | Huebner and Gutzeit, 1986 | [
"B71",
"B23",
"B98"
] | 20,926,687 | NA|NA|NA | Among the few known examples are the plasmodesmata channels that connect certain plant cells to one another, and the ring channels that connect Drosophila nurse cells to the oocyte that they supply (Huebner and Gutzeit, 1986; Cilia and Jackson, 2004; Mische et al., 2007). | [
"Huebner and Gutzeit, 1986",
"Cilia and Jackson, 2004",
"Mische "
] | 272 | 41,464 | 0 | false | Among the few known examples are the plasmodesmata channels that connect certain plant cells to one another, and the ring channels that connect Drosophila nurse cells to the oocyte that they supply. | [
"Huebner and Gutzeit, 1986; Cilia and Jackson, 2004; Mische et al., 2007"
] | Among the few known examples are the plasmodesmata channels that connect certain plant cells to one another, and the ring channels that connect Drosophila nurse cells to the oocyte that they supply. | true | true | true | true | true | 7,150 |
9 | DISCUSSION | 1 | Huebner and Gutzeit, 1986 | [
"B71",
"B23",
"B98"
] | 20,926,687 | NA|NA|NA | These two examples, however, are thought to result from incomplete cytokinesis, rather than by fusion pore expansion and stabilization as in the case of the NPC. | [
"Huebner and Gutzeit, 1986",
"Cilia and Jackson, 2004",
"Mische "
] | 161 | 41,465 | 0 | false | These two examples, however, are thought to result from incomplete cytokinesis, rather than by fusion pore expansion and stabilization as in the case of the NPC. | [] | These two examples, however, are thought to result from incomplete cytokinesis, rather than by fusion pore expansion and stabilization as in the case of the NPC. | true | true | true | true | true | 7,150 |
9 | DISCUSSION | 1 | Huebner and Gutzeit, 1986 | [
"B71",
"B23",
"B98"
] | 20,926,687 | NA|NA|NA | The stabilized inner/outer membrane fusion product that is the nuclear pore complex may thus be a unique occurence in evolution. | [
"Huebner and Gutzeit, 1986",
"Cilia and Jackson, 2004",
"Mische "
] | 128 | 41,466 | 0 | false | The stabilized inner/outer membrane fusion product that is the nuclear pore complex may thus be a unique occurence in evolution. | [] | The stabilized inner/outer membrane fusion product that is the nuclear pore complex may thus be a unique occurence in evolution. | true | true | true | true | true | 7,150 |
10 | DISCUSSION | 0 | null | null | 20,926,687 | null | In conclusion, this study maps diffusion channel formation downstream from POM121 and Nup107-160 complex recruitment, and upstream or coincident with FG nucleoporin recruitment. | null | 177 | 41,467 | 0 | false | null | null | In conclusion, this study maps diffusion channel formation downstream from POM121 and Nup107-160 complex recruitment, and upstream or coincident with FG nucleoporin recruitment. | true | true | true | true | true | 7,151 |
10 | DISCUSSION | 0 | null | null | 20,926,687 | null | These results thus order the important fusion step in NPC assembly with respect to other key steps (Figure 8): (i) AT-rich chromatin recruitment of ELYS and the Nup107-160 complex, (ii) colocalization of the Nup107-160 complex with POM121/Ndc1 at the inner nuclear membrane, followed by (iii) inner/outer membrane fusion... | null | 381 | 41,468 | 0 | false | null | null | These results thus order the important fusion step in NPC assembly with respect to other key steps (Figure 8): (i) AT-rich chromatin recruitment of ELYS and the Nup107-160 complex, (ii) colocalization of the Nup107-160 complex with POM121/Ndc1 at the inner nuclear membrane, followed by (iii) inner/outer membrane fusion... | true | true | true | true | true | 7,151 |
10 | DISCUSSION | 0 | null | null | 20,926,687 | null | The frontier of nuclear pore assembly now requires identification of the fusogen and determination of the order of addition of the myriad subunits that go on to build the pore complex within this evolutionarily unique membranous channel. | null | 237 | 41,469 | 0 | false | null | null | The frontier of nuclear pore assembly now requires identification of the fusogen and determination of the order of addition of the myriad subunits that go on to build the pore complex within this evolutionarily unique membranous channel. | true | true | true | true | true | 7,151 |
11 | DISCUSSION | 0 | null | null | 20,926,687 | null | A schematic model for inner/outer nuclear membrane fusion in the early steps of vertebrate NPC assembly. | null | 104 | 41,470 | 0 | false | null | null | A schematic model for inner/outer nuclear membrane fusion in the early steps of vertebrate NPC assembly. | true | true | true | true | true | 7,152 |
11 | DISCUSSION | 0 | null | null | 20,926,687 | null | In previous studies, ELYS was shown to mediate the binding of the Nup107-160 complex to sites of AT-rich chromatin (blue) in early nuclear assembly. | null | 148 | 41,471 | 0 | false | null | null | In previous studies, ELYS was shown to mediate the binding of the Nup107-160 complex to sites of AT-rich chromatin (blue) in early nuclear assembly. | true | true | true | true | true | 7,152 |
11 | DISCUSSION | 0 | null | null | 20,926,687 | null | Simultaneous with this ER-derived membranes are recruited to the rim of developing nuclei. | null | 90 | 41,472 | 0 | false | null | null | Simultaneous with this ER-derived membranes are recruited to the rim of developing nuclei. | true | true | true | true | true | 7,152 |
11 | DISCUSSION | 0 | null | null | 20,926,687 | null | The data presented here argues that next: (1) the Nup107-160 complex (detected by anti-Nup133 antibody) interacts with POM121 at the inner nuclear membrane in an early nuclear intermediate (30 min, 14°C). | null | 204 | 41,473 | 0 | false | null | null | The data presented here argues that next: (1) the Nup107-160 complex (detected by anti-Nup133 antibody) interacts with POM121 at the inner nuclear membrane in an early nuclear intermediate (30 min, 14°C). | true | true | true | true | true | 7,152 |
11 | DISCUSSION | 0 | null | null | 20,926,687 | null | Bending of the membranes toward one another would theoretically occur at or near this time. | null | 91 | 41,474 | 0 | false | null | null | Bending of the membranes toward one another would theoretically occur at or near this time. | true | true | true | true | true | 7,152 |
11 | DISCUSSION | 0 | null | null | 20,926,687 | null | (2) This is followed by fusion of the inner and outer nuclear membranes to form a diffusion channel. | null | 100 | 41,475 | 0 | false | null | null | (2) This is followed by fusion of the inner and outer nuclear membranes to form a diffusion channel. | false | false | true | true | false | 7,152 |
11 | DISCUSSION | 0 | null | null | 20,926,687 | null | (3) This fusion is simultaneous with or precedes recruitment of the bulk of FG nucleoporins (gold) and assembly of the mature nuclear pore, which involves expansion of the initial channel and its stabilization. | null | 210 | 41,476 | 0 | false | null | null | (3) This fusion is simultaneous with or precedes recruitment of the bulk of FG nucleoporins (gold) and assembly of the mature nuclear pore, which involves expansion of the initial channel and its stabilization. | false | false | true | true | false | 7,152 |
11 | DISCUSSION | 0 | null | null | 20,926,687 | null | In pioneering membrane-membrane fusion studies, progression to hemifusion was seen to be typically inhibited by cone-shaped lipids, such as LPC; here LPC was found to indeed block channel formation and FG Nup assembly in nuclear intermediates. | null | 243 | 41,477 | 0 | false | null | null | In pioneering membrane-membrane fusion studies, progression to hemifusion was seen to be typically inhibited by cone-shaped lipids, such as LPC; here LPC was found to indeed block channel formation and FG Nup assembly in nuclear intermediates. | true | true | true | true | true | 7,152 |
11 | DISCUSSION | 0 | null | null | 20,926,687 | null | Progression beyond hemifusion to full fusion has been observed to be inhibited by inverted cone-shaped lipids, such as OA; here we found that OA also blocks mature nuclear pore assembly. | null | 186 | 41,478 | 0 | false | null | null | Progression beyond hemifusion to full fusion has been observed to be inhibited by inverted cone-shaped lipids, such as OA; here we found that OA also blocks mature nuclear pore assembly. | true | true | true | true | true | 7,152 |
11 | DISCUSSION | 0 | null | null | 20,926,687 | null | When added together LPC and OA are known to geometrically neutralize one another, and we observed that LPC+OA allow channel formation, i.e., inner/outer membrane fusion. | null | 169 | 41,479 | 0 | false | null | null | When added together LPC and OA are known to geometrically neutralize one another, and we observed that LPC+OA allow channel formation, i.e., inner/outer membrane fusion. | true | true | true | true | true | 7,152 |
11 | DISCUSSION | 0 | null | null | 20,926,687 | null | (It is important to note that we do not believe that a completely sealed nuclear envelope is required before nuclear pores can form, but possession of such a sealed intermediate allowed us to distinguish and analyze the channel formation step of nuclear pore assembly.) | null | 269 | 41,480 | 0 | false | null | null | (It is important to note that we do not believe that a completely sealed nuclear envelope is required before nuclear pores can form, but possession of such a sealed intermediate allowed us to distinguish and analyze the channel formation step of nuclear pore assembly.) | false | false | false | true | false | 7,152 |
0 | DISCUSSION | 1 | 20 | [
"bib20"
] | 19,047,440 | pmid-6978196 | In this study, we have used systems biology and polychromatic flow cytometry to characterize the early immunological processes that are initiated by one of the most potent vaccines ever generated, the YF vaccine YF17D, and which culminate into persistent immunological memory and long-term protection against a challenge... | [
"20"
] | 336 | 41,481 | 1 | false | In this study, we have used systems biology and polychromatic flow cytometry to characterize the early immunological processes that are initiated by one of the most potent vaccines ever generated, the YF vaccine YF17D, and which culminate into persistent immunological memory and long-term protection against a challenge... | [
"20"
] | In this study, we have used systems biology and polychromatic flow cytometry to characterize the early immunological processes that are initiated by one of the most potent vaccines ever generated, the YF vaccine YF17D, and which culminate into persistent immunological memory and long-term protection against a challenge... | true | true | true | true | true | 7,153 |
0 | DISCUSSION | 1 | 20 | [
"bib20"
] | 19,047,440 | pmid-6978196 | The vaccine induced a significant modulation of 594 genes in whole blood cells, with the highest number of genes being induced at day 7 after vaccination. | [
"20"
] | 154 | 41,482 | 0 | false | The vaccine induced a significant modulation of 594 genes in whole blood cells, with the highest number of genes being induced at day 7 after vaccination. | [] | The vaccine induced a significant modulation of 594 genes in whole blood cells, with the highest number of genes being induced at day 7 after vaccination. | true | true | true | true | true | 7,153 |
0 | DISCUSSION | 1 | 20 | [
"bib20"
] | 19,047,440 | pmid-6978196 | ICA and gene set enrichment allowed us to identify several nodes of transcriptional regulation that became induced within the first week after immunization. | [
"20"
] | 156 | 41,483 | 0 | false | ICA and gene set enrichment allowed us to identify several nodes of transcriptional regulation that became induced within the first week after immunization. | [] | ICA and gene set enrichment allowed us to identify several nodes of transcriptional regulation that became induced within the first week after immunization. | true | true | true | true | true | 7,153 |
0 | DISCUSSION | 1 | 20 | [
"bib20"
] | 19,047,440 | pmid-6978196 | This early response was highly integrated, as several of the downstream target genes were coordinately regulated by these transcription factors. | [
"20"
] | 144 | 41,484 | 0 | false | This early response was highly integrated, as several of the downstream target genes were coordinately regulated by these transcription factors. | [] | This early response was highly integrated, as several of the downstream target genes were coordinately regulated by these transcription factors. | true | true | true | true | true | 7,153 |
1 | DISCUSSION | 1 | 21 | [
"bib21",
"bib22",
"bib23",
"bib22",
"bib24"
] | 19,047,440 | pmid-18272964|pmid-15800576|pmid-16461338|pmid-15800576|pmid-16410796 | Of the identified nodes, IRF7 was prominently involved in this masterswitch regulation. | [
"21",
"22",
"23",
"22",
"24"
] | 87 | 41,485 | 0 | false | Of the identified nodes, IRF7 was prominently involved in this masterswitch regulation. | [] | Of the identified nodes, IRF7 was prominently involved in this masterswitch regulation. | true | true | true | true | true | 7,154 |
1 | DISCUSSION | 1 | 21 | [
"bib21",
"bib22",
"bib23",
"bib22",
"bib24"
] | 19,047,440 | pmid-18272964|pmid-15800576|pmid-16461338|pmid-15800576|pmid-16410796 | The induction of IRF7 has been shown to mediate innate and adaptive immunity against many viruses, including encephalomyocarditis virus, vesicular stomatitis virus, influenza virus, and Sindbis virus (21, 22), confirming the significance of this gene in mediating protective immunity and in inducing strong innate and ad... | [
"21",
"22",
"23",
"22",
"24"
] | 344 | 41,486 | 0 | false | The induction of IRF7 has been shown to mediate innate and adaptive immunity against many viruses, including encephalomyocarditis virus, vesicular stomatitis virus, influenza virus, and Sindbis virus, confirming the significance of this gene in mediating protective immunity and in inducing strong innate and adaptive im... | [
"21, 22"
] | The induction of IRF7 has been shown to mediate innate and adaptive immunity against many viruses, including encephalomyocarditis virus, vesicular stomatitis virus, influenza virus, and Sindbis virus, confirming the significance of this gene in mediating protective immunity and in inducing strong innate and adaptive im... | true | true | true | true | true | 7,154 |
1 | DISCUSSION | 1 | 23 | [
"bib21",
"bib22",
"bib23",
"bib22",
"bib24"
] | 19,047,440 | pmid-18272964|pmid-15800576|pmid-16461338|pmid-15800576|pmid-16410796 | It was also recently reported that the YF17D virus activates DCs by triggering their TLR2, 7, 8, and 9 (23). | [
"21",
"22",
"23",
"22",
"24"
] | 108 | 41,487 | 1 | false | It was also recently reported that the YF17D virus activates DCs by triggering their TLR2, 7, 8, and 9. | [
"23"
] | It was also recently reported that the YF17D virus activates DCs by triggering their TLR2, 7, 8, and 9. | true | true | true | true | true | 7,154 |
1 | DISCUSSION | 1 | 21 | [
"bib21",
"bib22",
"bib23",
"bib22",
"bib24"
] | 19,047,440 | pmid-18272964|pmid-15800576|pmid-16461338|pmid-15800576|pmid-16410796 | Our data reveal that TLR7 and its downstream adaptor molecule Myd88 are both up-regulated upon vaccination with YF17D. | [
"21",
"22",
"23",
"22",
"24"
] | 118 | 41,488 | 0 | false | Our data reveal that TLR7 and its downstream adaptor molecule Myd88 are both up-regulated upon vaccination with YF17D. | [] | Our data reveal that TLR7 and its downstream adaptor molecule Myd88 are both up-regulated upon vaccination with YF17D. | true | true | true | true | true | 7,154 |
1 | DISCUSSION | 1 | 21 | [
"bib21",
"bib22",
"bib23",
"bib22",
"bib24"
] | 19,047,440 | pmid-18272964|pmid-15800576|pmid-16461338|pmid-15800576|pmid-16410796 | TLR7 is a molecular sensor for single-stranded RNA, such as the nucleic acid found in YF17D and other flaviviruses, and triggering of TLR7 causes the transduction of a signal, via Myd88, to up-regulate expression of inflammatory cytokines such as IL-6, IL-12, and TNF (via NF-κB) and type I IFNs (via IRF7) (22, 24). | [
"21",
"22",
"23",
"22",
"24"
] | 316 | 41,489 | 0 | false | TLR7 is a molecular sensor for single-stranded RNA, such as the nucleic acid found in YF17D and other flaviviruses, and triggering of TLR7 causes the transduction of a signal, via Myd88, to up-regulate expression of inflammatory cytokines such as IL-6, IL-12, and TNF (via NF-κB) and type I IFNs (via IRF7). | [
"22, 24"
] | TLR7 is a molecular sensor for single-stranded RNA, such as the nucleic acid found in YF17D and other flaviviruses, and triggering of TLR7 causes the transduction of a signal, via Myd88, to up-regulate expression of inflammatory cytokines such as IL-6, IL-12, and TNF (via NF-κB) and type I IFNs (via IRF7). | true | true | true | true | true | 7,154 |
1 | DISCUSSION | 1 | 21 | [
"bib21",
"bib22",
"bib23",
"bib22",
"bib24"
] | 19,047,440 | pmid-18272964|pmid-15800576|pmid-16461338|pmid-15800576|pmid-16410796 | Type I IFNs in turn enhance the expression of proteins with direct antiviral activity, such as ISG20 and OAS1, 2, and 3, which lead to viral RNA degradation, and MX1, MX2, ADAR, and EIF2AK2, which inhibit viral replication. | [
"21",
"22",
"23",
"22",
"24"
] | 223 | 41,490 | 0 | false | Type I IFNs in turn enhance the expression of proteins with direct antiviral activity, such as ISG20 and OAS1, 2, and 3, which lead to viral RNA degradation, and MX1, MX2, ADAR, and EIF2AK2, which inhibit viral replication. | [] | Type I IFNs in turn enhance the expression of proteins with direct antiviral activity, such as ISG20 and OAS1, 2, and 3, which lead to viral RNA degradation, and MX1, MX2, ADAR, and EIF2AK2, which inhibit viral replication. | true | true | true | true | true | 7,154 |
1 | DISCUSSION | 1 | 21 | [
"bib21",
"bib22",
"bib23",
"bib22",
"bib24"
] | 19,047,440 | pmid-18272964|pmid-15800576|pmid-16461338|pmid-15800576|pmid-16410796 | We are showing that all these genes are up-regulated upon YF17D vaccination. | [
"21",
"22",
"23",
"22",
"24"
] | 76 | 41,491 | 0 | false | We are showing that all these genes are up-regulated upon YF17D vaccination. | [] | We are showing that all these genes are up-regulated upon YF17D vaccination. | true | true | true | true | true | 7,154 |
2 | DISCUSSION | 1 | 25 | [
"bib25",
"bib26",
"bib27",
"bib28",
"bib25",
"bib29"
] | 19,047,440 | pmid-16652219|pmid-2187191|pmid-16518544|pmid-10212281|pmid-16652219|pmid-8413265 | Another prominent node of transcription regulation induced by YF17D vaccination is the ETS2 transcription factor. | [
"25",
"26",
"27",
"28",
"25",
"29"
] | 113 | 41,492 | 0 | false | Another prominent node of transcription regulation induced by YF17D vaccination is the ETS2 transcription factor. | [] | Another prominent node of transcription regulation induced by YF17D vaccination is the ETS2 transcription factor. | true | true | true | true | true | 7,155 |
2 | DISCUSSION | 1 | 25 | [
"bib25",
"bib26",
"bib27",
"bib28",
"bib25",
"bib29"
] | 19,047,440 | pmid-16652219|pmid-2187191|pmid-16518544|pmid-10212281|pmid-16652219|pmid-8413265 | ETS2 is involved in the differentiation and maturation of several immune cell types (25). | [
"25",
"26",
"27",
"28",
"25",
"29"
] | 89 | 41,493 | 1 | false | ETS2 is involved in the differentiation and maturation of several immune cell types. | [
"25"
] | ETS2 is involved in the differentiation and maturation of several immune cell types. | true | true | true | true | true | 7,155 |
2 | DISCUSSION | 1 | 26 | [
"bib25",
"bib26",
"bib27",
"bib28",
"bib25",
"bib29"
] | 19,047,440 | pmid-16652219|pmid-2187191|pmid-16518544|pmid-10212281|pmid-16652219|pmid-8413265 | Its expression is up-regulated in activated and proliferating T cells (26) and ETS2 is involved in IL-12 p40 (Th1) and IL-5 (Th2) gene expression (27, 28). | [
"25",
"26",
"27",
"28",
"25",
"29"
] | 155 | 41,494 | 1 | false | Its expression is up-regulated in activated and proliferating T cells and ETS2 is involved in IL-12 p40 (Th1) and IL-5 (Th2) gene expression. | [
"26",
"27, 28"
] | Its expression is up-regulated in activated and proliferating T cells and ETS2 is involved in IL-12 p40 (Th1) and IL-5 gene expression. | true | true | true | true | true | 7,155 |
2 | DISCUSSION | 1 | 25 | [
"bib25",
"bib26",
"bib27",
"bib28",
"bib25",
"bib29"
] | 19,047,440 | pmid-16652219|pmid-2187191|pmid-16518544|pmid-10212281|pmid-16652219|pmid-8413265 | ETS2 obviously plays a key role in the highly integrated response to YF17D, as it enhanced transcription of several downstream genes that play critical roles in the maturation and differentiation of T cells, B cells, NK cells, and macrophages (Fig. | [
"25",
"26",
"27",
"28",
"25",
"29"
] | 248 | 41,495 | 0 | false | ETS2 obviously plays a key role in the highly integrated response to YF17D, as it enhanced transcription of several downstream genes that play critical roles in the maturation and differentiation of T cells, B cells, NK cells, and macrophages (Fig. | [] | ETS2 obviously plays a key role in the highly integrated response to YF17D, as it enhanced transcription of several downstream genes that play critical roles in the maturation and differentiation of T cells, B cells, NK cells, and macrophages (Fig. | true | true | true | true | true | 7,155 |
2 | DISCUSSION | 1 | 25 | [
"bib25",
"bib26",
"bib27",
"bib28",
"bib25",
"bib29"
] | 19,047,440 | pmid-16652219|pmid-2187191|pmid-16518544|pmid-10212281|pmid-16652219|pmid-8413265 | 3, and Fig. | [
"25",
"26",
"27",
"28",
"25",
"29"
] | 11 | 41,496 | 0 | false | 3, and Fig. | [] | 3, and Fig. | false | false | true | true | false | 7,155 |
2 | DISCUSSION | 1 | 25 | [
"bib25",
"bib26",
"bib27",
"bib28",
"bib25",
"bib29"
] | 19,047,440 | pmid-16652219|pmid-2187191|pmid-16518544|pmid-10212281|pmid-16652219|pmid-8413265 | Indeed, antigen-presenting cell–specific genes that are targets of ETS2 were up-regulated early after vaccination (MARCO, CD86). | [
"25",
"26",
"27",
"28",
"25",
"29"
] | 128 | 41,497 | 0 | false | Indeed, antigen-presenting cell–specific genes that are targets of ETS2 were up-regulated early after vaccination (MARCO, CD86). | [] | Indeed, antigen-presenting cell–specific genes that are targets of ETS2 were up-regulated early after vaccination (MARCO, CD86). | true | true | true | true | true | 7,155 |
2 | DISCUSSION | 1 | 25 | [
"bib25",
"bib26",
"bib27",
"bib28",
"bib25",
"bib29"
] | 19,047,440 | pmid-16652219|pmid-2187191|pmid-16518544|pmid-10212281|pmid-16652219|pmid-8413265 | The role of ETS2 in the early induction of innate immunity is further demonstrated by the increased expression of NK cell receptors, as well as several cytolytic molecules; KIRDL3, PRF1, and GZMB are known targets of members of the Ets family of transcription factors (25, 29). | [
"25",
"26",
"27",
"28",
"25",
"29"
] | 277 | 41,498 | 0 | false | The role of ETS2 in the early induction of innate immunity is further demonstrated by the increased expression of NK cell receptors, as well as several cytolytic molecules; KIRDL3, PRF1, and GZMB are known targets of members of the Ets family of transcription factors. | [
"25, 29"
] | The role of ETS2 in the early induction of innate immunity is further demonstrated by the increased expression of NK cell receptors, as well as several cytolytic molecules; KIRDL3, PRF1, and GZMB are known targets of members of the Ets family of transcription factors. | true | true | true | true | true | 7,155 |
2 | DISCUSSION | 1 | 25 | [
"bib25",
"bib26",
"bib27",
"bib28",
"bib25",
"bib29"
] | 19,047,440 | pmid-16652219|pmid-2187191|pmid-16518544|pmid-10212281|pmid-16652219|pmid-8413265 | Moreover, flow cytometry analysis on PBMCs from vaccinated volunteers revealed that YF17D stimulates the proliferation of several leukocyte populations (Fig. | [
"25",
"26",
"27",
"28",
"25",
"29"
] | 157 | 41,499 | 0 | false | Moreover, flow cytometry analysis on PBMCs from vaccinated volunteers revealed that YF17D stimulates the proliferation of several leukocyte populations (Fig. | [] | Moreover, flow cytometry analysis on PBMCs from vaccinated volunteers revealed that YF17D stimulates the proliferation of several leukocyte populations (Fig. | true | true | true | true | true | 7,155 |
3 | DISCUSSION | 1 | 30 | [
"bib30",
"bib31",
"bib33",
"bib34",
"bib35",
"bib36",
"bib37",
"bib38",
"bib39",
"bib40"
] | 19,047,440 | pmid-9865486|pmid-12417340|pmid-15489234|pmid-15153500|pmid-16380510|pmid-17038524|pmid-14651981|pmid-7892279|pmid-18311149|pmid-12149244 | Several of the other predicted transcription nodes are likely to play significant roles in the induction of innate and adaptive immunity in response to YF17D. | [
"30",
"31",
"33",
"34",
"35",
"36",
"37",
"38",
"39",
"40"
] | 158 | 41,500 | 0 | false | Several of the other predicted transcription nodes are likely to play significant roles in the induction of innate and adaptive immunity in response to YF17D. | [] | Several of the other predicted transcription nodes are likely to play significant roles in the induction of innate and adaptive immunity in response to YF17D. | true | true | true | true | true | 7,156 |
3 | DISCUSSION | 1 | 30 | [
"bib30",
"bib31",
"bib33",
"bib34",
"bib35",
"bib36",
"bib37",
"bib38",
"bib39",
"bib40"
] | 19,047,440 | pmid-9865486|pmid-12417340|pmid-15489234|pmid-15153500|pmid-16380510|pmid-17038524|pmid-14651981|pmid-7892279|pmid-18311149|pmid-12149244 | IRF1 mediates the antiviral activity of IFNs, similar to IRF7 (30). | [
"30",
"31",
"33",
"34",
"35",
"36",
"37",
"38",
"39",
"40"
] | 67 | 41,501 | 1 | false | IRF1 mediates the antiviral activity of IFNs, similar to IRF7. | [
"30"
] | IRF1 mediates the antiviral activity of IFNs, similar to IRF7. | true | true | true | true | true | 7,156 |
3 | DISCUSSION | 1 | 30 | [
"bib30",
"bib31",
"bib33",
"bib34",
"bib35",
"bib36",
"bib37",
"bib38",
"bib39",
"bib40"
] | 19,047,440 | pmid-9865486|pmid-12417340|pmid-15489234|pmid-15153500|pmid-16380510|pmid-17038524|pmid-14651981|pmid-7892279|pmid-18311149|pmid-12149244 | IRF1 and IRF8 were found to synergistically activate IL-12 p35 and p40 gene expression in macrophages (31–33). | [
"30",
"31",
"33",
"34",
"35",
"36",
"37",
"38",
"39",
"40"
] | 110 | 41,502 | 0 | false | IRF1 and IRF8 were found to synergistically activate IL-12 p35 and p40 gene expression in macrophages. | [
"31–33"
] | IRF1 and IRF8 were found to synergistically activate IL-12 p35 and p40 gene expression in macrophages. | true | true | true | true | true | 7,156 |
3 | DISCUSSION | 1 | 34 | [
"bib30",
"bib31",
"bib33",
"bib34",
"bib35",
"bib36",
"bib37",
"bib38",
"bib39",
"bib40"
] | 19,047,440 | pmid-9865486|pmid-12417340|pmid-15489234|pmid-15153500|pmid-16380510|pmid-17038524|pmid-14651981|pmid-7892279|pmid-18311149|pmid-12149244 | IRF8 also mediates activation of NF-κB upon TLR9 triggering in DCs (34), and IRF8 and LMO2 were both found to be expressed in B cell germinal centers, suggesting a role in the development of the humoral response (35, 36). | [
"30",
"31",
"33",
"34",
"35",
"36",
"37",
"38",
"39",
"40"
] | 221 | 41,503 | 1 | false | IRF8 also mediates activation of NF-κB upon TLR9 triggering in DCs, and IRF8 and LMO2 were both found to be expressed in B cell germinal centers, suggesting a role in the development of the humoral response. | [
"34",
"35, 36"
] | IRF8 also mediates activation of NF-κB upon TLR9 triggering in DCs, and IRF8 and LMO2 were both found to be expressed in B cell germinal centers, suggesting a role in the development of the humoral response. | true | true | true | true | true | 7,156 |
3 | DISCUSSION | 1 | 37 | [
"bib30",
"bib31",
"bib33",
"bib34",
"bib35",
"bib36",
"bib37",
"bib38",
"bib39",
"bib40"
] | 19,047,440 | pmid-9865486|pmid-12417340|pmid-15489234|pmid-15153500|pmid-16380510|pmid-17038524|pmid-14651981|pmid-7892279|pmid-18311149|pmid-12149244 | Moreover, TAL1 may be involved in T cell proliferation and differentiation (37). | [
"30",
"31",
"33",
"34",
"35",
"36",
"37",
"38",
"39",
"40"
] | 80 | 41,504 | 1 | false | Moreover, TAL1 may be involved in T cell proliferation and differentiation. | [
"37"
] | Moreover, TAL1 may be involved in T cell proliferation and differentiation. | true | true | true | true | true | 7,156 |
3 | DISCUSSION | 1 | 38 | [
"bib30",
"bib31",
"bib33",
"bib34",
"bib35",
"bib36",
"bib37",
"bib38",
"bib39",
"bib40"
] | 19,047,440 | pmid-9865486|pmid-12417340|pmid-15489234|pmid-15153500|pmid-16380510|pmid-17038524|pmid-14651981|pmid-7892279|pmid-18311149|pmid-12149244 | E2F4 is involved in cell cycle regulation (38), and FOXO3A and E2F1 are mediators of apoptosis (39, 40). | [
"30",
"31",
"33",
"34",
"35",
"36",
"37",
"38",
"39",
"40"
] | 104 | 41,505 | 1 | false | E2F4 is involved in cell cycle regulation, and FOXO3A and E2F1 are mediators of apoptosis. | [
"38",
"39, 40"
] | E2F4 is involved in cell cycle regulation, and FOXO3A and E2F1 are mediators of apoptosis. | true | true | true | true | true | 7,156 |
4 | DISCUSSION | 1 | 41 | [
"bib41",
"bib42",
"bib43",
"bib44",
"bib45",
"bib46",
"bib47",
"bib43",
"bib48"
] | 19,047,440 | pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108 | A common feature of these masterswitch genes is that they control the induction of several pathways of the innate immune response, including type I IFNs, but also the inflammasome and complement. | [
"41",
"42",
"43",
"44",
"45",
"46",
"47",
"43",
"48"
] | 195 | 41,506 | 0 | false | A common feature of these masterswitch genes is that they control the induction of several pathways of the innate immune response, including type I IFNs, but also the inflammasome and complement. | [] | A common feature of these masterswitch genes is that they control the induction of several pathways of the innate immune response, including type I IFNs, but also the inflammasome and complement. | true | true | true | true | true | 7,157 |
4 | DISCUSSION | 1 | 41 | [
"bib41",
"bib42",
"bib43",
"bib44",
"bib45",
"bib46",
"bib47",
"bib43",
"bib48"
] | 19,047,440 | pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108 | The inflammasome is a large protein assembly that includes pyrin- and CARD domain–containing adaptor proteins complexed with cysteine proteinases known as caspases. | [
"41",
"42",
"43",
"44",
"45",
"46",
"47",
"43",
"48"
] | 164 | 41,507 | 0 | false | The inflammasome is a large protein assembly that includes pyrin- and CARD domain–containing adaptor proteins complexed with cysteine proteinases known as caspases. | [] | The inflammasome is a large protein assembly that includes pyrin- and CARD domain–containing adaptor proteins complexed with cysteine proteinases known as caspases. | true | true | true | true | true | 7,157 |
4 | DISCUSSION | 1 | 41 | [
"bib41",
"bib42",
"bib43",
"bib44",
"bib45",
"bib46",
"bib47",
"bib43",
"bib48"
] | 19,047,440 | pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108 | It mediates the processing and activation of these caspases, and subsequently the cleavage and secretion of the proinflammatory cytokines IL-1β and -18 (41). | [
"41",
"42",
"43",
"44",
"45",
"46",
"47",
"43",
"48"
] | 157 | 41,508 | 1 | false | It mediates the processing and activation of these caspases, and subsequently the cleavage and secretion of the proinflammatory cytokines IL-1β and -18. | [
"41"
] | It mediates the processing and activation of these caspases, and subsequently the cleavage and secretion of the proinflammatory cytokines IL-1β and -18. | true | true | true | true | true | 7,157 |
4 | DISCUSSION | 1 | 42 | [
"bib41",
"bib42",
"bib43",
"bib44",
"bib45",
"bib46",
"bib47",
"bib43",
"bib48"
] | 19,047,440 | pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108 | Activation of the inflammasome has been recently shown to be induced by adenoviruses (42), and to be a key event for the successful adjuvant effect of alum, one of the only two adjuvants licensed to be used in humans (43). | [
"41",
"42",
"43",
"44",
"45",
"46",
"47",
"43",
"48"
] | 222 | 41,509 | 1 | false | Activation of the inflammasome has been recently shown to be induced by adenoviruses, and to be a key event for the successful adjuvant effect of alum, one of the only two adjuvants licensed to be used in humans. | [
"42",
"43"
] | Activation of the inflammasome has been recently shown to be induced by adenoviruses, and to be a key event for the successful adjuvant effect of alum, one of the only two adjuvants licensed to be used in humans. | true | true | true | true | true | 7,157 |
4 | DISCUSSION | 1 | 41 | [
"bib41",
"bib42",
"bib43",
"bib44",
"bib45",
"bib46",
"bib47",
"bib43",
"bib48"
] | 19,047,440 | pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108 | Our gene array results demonstrate that two components of the inflammasome, caspase-1 and -5, were up-regulated after YF17D vaccination, in volunteers from the Montreal cohort, whereas only caspase-1 is up-regulated in volunteers from the Lausanne cohort (Fig. | [
"41",
"42",
"43",
"44",
"45",
"46",
"47",
"43",
"48"
] | 260 | 41,510 | 0 | false | Our gene array results demonstrate that two components of the inflammasome, caspase-1 and -5, were up-regulated after YF17D vaccination, in volunteers from the Montreal cohort, whereas only caspase-1 is up-regulated in volunteers from the Lausanne cohort (Fig. | [] | Our gene array results demonstrate that two components of the inflammasome, caspase-1 and -5, were up-regulated after YF17D vaccination, in volunteers from the Montreal cohort, whereas only caspase-1 is up-regulated in volunteers from the Lausanne cohort (Fig. | true | true | true | true | true | 7,157 |
4 | DISCUSSION | 1 | 44 | [
"bib41",
"bib42",
"bib43",
"bib44",
"bib45",
"bib46",
"bib47",
"bib43",
"bib48"
] | 19,047,440 | pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108 | There are different kinds of inflammasomes, each containing a specific combination of inflammatory caspases and adaptor molecules (44). | [
"41",
"42",
"43",
"44",
"45",
"46",
"47",
"43",
"48"
] | 135 | 41,511 | 1 | false | There are different kinds of inflammasomes, each containing a specific combination of inflammatory caspases and adaptor molecules. | [
"44"
] | There are different kinds of inflammasomes, each containing a specific combination of inflammatory caspases and adaptor molecules. | true | true | true | true | true | 7,157 |
4 | DISCUSSION | 1 | 41 | [
"bib41",
"bib42",
"bib43",
"bib44",
"bib45",
"bib46",
"bib47",
"bib43",
"bib48"
] | 19,047,440 | pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108 | Hence, NALP1 inflammasomes contain ASC, NALP1, caspase-1, and caspase-5, whereas NALP3 inflammasomes contain ASC, NALP3, and caspase-1 (no caspase-5). | [
"41",
"42",
"43",
"44",
"45",
"46",
"47",
"43",
"48"
] | 150 | 41,512 | 0 | false | Hence, NALP1 inflammasomes contain ASC, NALP1, caspase-1, and caspase-5, whereas NALP3 inflammasomes contain ASC, NALP3, and caspase-1 (no caspase-5). | [] | Hence, NALP1 inflammasomes contain ASC, NALP1, caspase-1, and caspase-5, whereas NALP3 inflammasomes contain ASC, NALP3, and caspase-1 (no caspase-5). | true | true | true | true | true | 7,157 |
4 | DISCUSSION | 1 | 41 | [
"bib41",
"bib42",
"bib43",
"bib44",
"bib45",
"bib46",
"bib47",
"bib43",
"bib48"
] | 19,047,440 | pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108 | It is possible that NALP1 inflammasomes were not induced in volunteers from the Lausanne cohort, whereas NALP3 inflammasomes were induced in both cohorts. | [
"41",
"42",
"43",
"44",
"45",
"46",
"47",
"43",
"48"
] | 154 | 41,513 | 0 | false | It is possible that NALP1 inflammasomes were not induced in volunteers from the Lausanne cohort, whereas NALP3 inflammasomes were induced in both cohorts. | [] | It is possible that NALP1 inflammasomes were not induced in volunteers from the Lausanne cohort, whereas NALP3 inflammasomes were induced in both cohorts. | true | true | true | true | true | 7,157 |
4 | DISCUSSION | 1 | 41 | [
"bib41",
"bib42",
"bib43",
"bib44",
"bib45",
"bib46",
"bib47",
"bib43",
"bib48"
] | 19,047,440 | pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108 | Interestingly, our gene array data also show a modulation of genes that are involved in IL-1β signaling, IL-1R2 and IL-1RN. | [
"41",
"42",
"43",
"44",
"45",
"46",
"47",
"43",
"48"
] | 123 | 41,514 | 0 | false | Interestingly, our gene array data also show a modulation of genes that are involved in IL-1β signaling, IL-1R2 and IL-1RN. | [] | Interestingly, our gene array data also show a modulation of genes that are involved in IL-1β signaling, IL-1R2 and IL-1RN. | true | true | true | true | true | 7,157 |
4 | DISCUSSION | 1 | 45 | [
"bib41",
"bib42",
"bib43",
"bib44",
"bib45",
"bib46",
"bib47",
"bib43",
"bib48"
] | 19,047,440 | pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108 | IL-1R2, which is a decoy receptor that competes with the binding of IL-1β to its receptor (45), is down-regulated, further confirming increased inflammasome activities and IL-1β processing and secretion after immunization with YF17D. | [
"41",
"42",
"43",
"44",
"45",
"46",
"47",
"43",
"48"
] | 233 | 41,515 | 1 | false | IL-1R2, which is a decoy receptor that competes with the binding of IL-1β to its receptor, is down-regulated, further confirming increased inflammasome activities and IL-1β processing and secretion after immunization with YF17D. | [
"45"
] | IL-1R2, which is a decoy receptor that competes with the binding of IL-1β to its receptor, is down-regulated, further confirming increased inflammasome activities and IL-1β processing and secretion after immunization with YF17D. | true | true | true | true | true | 7,157 |
4 | DISCUSSION | 1 | 41 | [
"bib41",
"bib42",
"bib43",
"bib44",
"bib45",
"bib46",
"bib47",
"bib43",
"bib48"
] | 19,047,440 | pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108 | The gene encoding IL-1RN, a cytokine that is an IL-1R antagonist, is up-regulated upon vaccination; this increase could be part of a negative feedback loop or could be caused by the up-regulation of STAT1 and STAT2, two transcription factors that induce IL-1RN up-regulation (46, 47). | [
"41",
"42",
"43",
"44",
"45",
"46",
"47",
"43",
"48"
] | 284 | 41,516 | 0 | false | The gene encoding IL-1RN, a cytokine that is an IL-1R antagonist, is up-regulated upon vaccination; this increase could be part of a negative feedback loop or could be caused by the up-regulation of STAT1 and STAT2, two transcription factors that induce IL-1RN up-regulation. | [
"46, 47"
] | The gene encoding IL-1RN, a cytokine that is an IL-1R antagonist, is up-regulated upon vaccination; this increase could be part of a negative feedback loop or could be caused by the up-regulation of STAT1 and STAT2, two transcription factors that induce IL-1RN up-regulation. | true | true | true | true | true | 7,157 |
4 | DISCUSSION | 1 | 41 | [
"bib41",
"bib42",
"bib43",
"bib44",
"bib45",
"bib46",
"bib47",
"bib43",
"bib48"
] | 19,047,440 | pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108 | Activation of the inflammasome by YF17D was confirmed at the protein level by incubating immature DCs with the virus and assessing their IL-1β secretion. | [
"41",
"42",
"43",
"44",
"45",
"46",
"47",
"43",
"48"
] | 153 | 41,517 | 0 | false | Activation of the inflammasome by YF17D was confirmed at the protein level by incubating immature DCs with the virus and assessing their IL-1β secretion. | [] | Activation of the inflammasome by YF17D was confirmed at the protein level by incubating immature DCs with the virus and assessing their IL-1β secretion. | true | true | true | true | true | 7,157 |
4 | DISCUSSION | 1 | 41 | [
"bib41",
"bib42",
"bib43",
"bib44",
"bib45",
"bib46",
"bib47",
"bib43",
"bib48"
] | 19,047,440 | pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108 | Representative results of ex vivo experiments performed on cells from a minimum of three individuals are shown in Fig. | [
"41",
"42",
"43",
"44",
"45",
"46",
"47",
"43",
"48"
] | 118 | 41,518 | 0 | false | Representative results of ex vivo experiments performed on cells from a minimum of three individuals are shown in Fig. | [] | Representative results of ex vivo experiments performed on cells from a minimum of three individuals are shown in Fig. | true | true | true | true | true | 7,157 |
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