Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
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4
DISCUSSION
1
41
[ "bib41", "bib42", "bib43", "bib44", "bib45", "bib46", "bib47", "bib43", "bib48" ]
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5 b and Fig.
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5 b and Fig.
[]
5 b and Fig.
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7,157
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DISCUSSION
1
41
[ "bib41", "bib42", "bib43", "bib44", "bib45", "bib46", "bib47", "bib43", "bib48" ]
19,047,440
pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108
S4, and clearly validate the gene expression data, as we could observe a significant up-regulation (up to ninefold) of IL-1β, which is a critical indicator of inflammasome formation and activation.
[ "41", "42", "43", "44", "45", "46", "47", "43", "48" ]
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S4, and clearly validate the gene expression data, as we could observe a significant up-regulation (up to ninefold) of IL-1β, which is a critical indicator of inflammasome formation and activation.
[]
S4, and clearly validate the gene expression data, as we could observe a significant up-regulation (up to ninefold) of IL-1β, which is a critical indicator of inflammasome formation and activation.
true
true
true
true
true
7,157
4
DISCUSSION
1
41
[ "bib41", "bib42", "bib43", "bib44", "bib45", "bib46", "bib47", "bib43", "bib48" ]
19,047,440
pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108
Of note, we could also observe that the induction of this pathway was independent of viral replication, as both UV-inactivated virus, and to a lesser extent heat-inactivated virus, all induced the secretion of IL-1β.
[ "41", "42", "43", "44", "45", "46", "47", "43", "48" ]
216
41,521
0
false
Of note, we could also observe that the induction of this pathway was independent of viral replication, as both UV-inactivated virus, and to a lesser extent heat-inactivated virus, all induced the secretion of IL-1β.
[]
Of note, we could also observe that the induction of this pathway was independent of viral replication, as both UV-inactivated virus, and to a lesser extent heat-inactivated virus, all induced the secretion of IL-1β.
true
true
true
true
true
7,157
4
DISCUSSION
1
41
[ "bib41", "bib42", "bib43", "bib44", "bib45", "bib46", "bib47", "bib43", "bib48" ]
19,047,440
pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108
As shown in Fig.
[ "41", "42", "43", "44", "45", "46", "47", "43", "48" ]
16
41,522
0
false
As shown in Fig.
[]
As shown in Fig.
true
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true
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7,157
4
DISCUSSION
1
41
[ "bib41", "bib42", "bib43", "bib44", "bib45", "bib46", "bib47", "bib43", "bib48" ]
19,047,440
pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108
5 a, the modulation of inflammasome- and IL-1β–related genes also similarly occurred in the Lausanne cohort, where increased gene expression of caspase-1, IL-1RN, and the decrease in the expression of IL-1R2, further confirmed the activation of the inflammasome after YF17D vaccination.
[ "41", "42", "43", "44", "45", "46", "47", "43", "48" ]
286
41,523
0
false
5 a, the modulation of inflammasome- and IL-1β–related genes also similarly occurred in the Lausanne cohort, where increased gene expression of caspase-1, IL-1RN, and the decrease in the expression of IL-1R2, further confirmed the activation of the inflammasome after YF17D vaccination.
[]
5 a, the modulation of inflammasome- and IL-1β–related genes also similarly occurred in the Lausanne cohort, where increased gene expression of caspase-1, IL-1RN, and the decrease in the expression of IL-1R2, further confirmed the activation of the inflammasome after YF17D vaccination.
false
false
true
true
false
7,157
4
DISCUSSION
1
41
[ "bib41", "bib42", "bib43", "bib44", "bib45", "bib46", "bib47", "bib43", "bib48" ]
19,047,440
pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108
Altogether, these results confirm the importance of the inflammasome as a target of the YF17D vaccine.
[ "41", "42", "43", "44", "45", "46", "47", "43", "48" ]
102
41,524
0
false
Altogether, these results confirm the importance of the inflammasome as a target of the YF17D vaccine.
[]
Altogether, these results confirm the importance of the inflammasome as a target of the YF17D vaccine.
true
true
true
true
true
7,157
4
DISCUSSION
1
43
[ "bib41", "bib42", "bib43", "bib44", "bib45", "bib46", "bib47", "bib43", "bib48" ]
19,047,440
pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108
Whether this pathway is critical for the adjuvant effect of this vaccine remains to be determined, but is certainly suggested by the fact that the inflammasome is induced by immunization when alum is used as adjuvant (43).
[ "41", "42", "43", "44", "45", "46", "47", "43", "48" ]
222
41,525
1
false
Whether this pathway is critical for the adjuvant effect of this vaccine remains to be determined, but is certainly suggested by the fact that the inflammasome is induced by immunization when alum is used as adjuvant.
[ "43" ]
Whether this pathway is critical for the adjuvant effect of this vaccine remains to be determined, but is certainly suggested by the fact that the inflammasome is induced by immunization when alum is used as adjuvant.
true
true
true
true
true
7,157
4
DISCUSSION
1
48
[ "bib41", "bib42", "bib43", "bib44", "bib45", "bib46", "bib47", "bib43", "bib48" ]
19,047,440
pmid-17977705|pmid-18288107|pmid-18566365|pmid-15163405|pmid-11377293|pmid-18494930|pmid-11158047|pmid-18566365|pmid-17570108
Moreover, IL-1β is known to play an important role in the regulation of T cell activation at multiple levels, and polymorphisms in the IL-1β gene have been linked to smallpox vaccine–induced fever (48).
[ "41", "42", "43", "44", "45", "46", "47", "43", "48" ]
202
41,526
1
false
Moreover, IL-1β is known to play an important role in the regulation of T cell activation at multiple levels, and polymorphisms in the IL-1β gene have been linked to smallpox vaccine–induced fever.
[ "48" ]
Moreover, IL-1β is known to play an important role in the regulation of T cell activation at multiple levels, and polymorphisms in the IL-1β gene have been linked to smallpox vaccine–induced fever.
true
true
true
true
true
7,157
5
DISCUSSION
1
49
[ "bib49", "bib50", "bib51" ]
19,047,440
pmid-17383729|pmid-16651386|pmid-15919902
We observed that YF17D stimulated the up-regulation of components of the complement cascade in blood cells, namely C1qA and C1qB.
[ "49", "50", "51" ]
129
41,527
0
false
We observed that YF17D stimulated the up-regulation of components of the complement cascade in blood cells, namely C1qA and C1qB.
[]
We observed that YF17D stimulated the up-regulation of components of the complement cascade in blood cells, namely C1qA and C1qB.
true
true
true
true
true
7,158
5
DISCUSSION
1
49
[ "bib49", "bib50", "bib51" ]
19,047,440
pmid-17383729|pmid-16651386|pmid-15919902
These molecules have been shown to induce maturation of DCs (49).
[ "49", "50", "51" ]
65
41,528
1
false
These molecules have been shown to induce maturation of DCs.
[ "49" ]
These molecules have been shown to induce maturation of DCs.
true
true
true
true
true
7,158
5
DISCUSSION
1
49
[ "bib49", "bib50", "bib51" ]
19,047,440
pmid-17383729|pmid-16651386|pmid-15919902
Furthermore, distinct components of the complement pathway were found to be essential in the development of humoral and cellular immunity to another flavivirus, the West Nile Virus (50, 51).
[ "49", "50", "51" ]
190
41,529
0
false
Furthermore, distinct components of the complement pathway were found to be essential in the development of humoral and cellular immunity to another flavivirus, the West Nile Virus.
[ "50, 51" ]
Furthermore, distinct components of the complement pathway were found to be essential in the development of humoral and cellular immunity to another flavivirus, the West Nile Virus.
true
true
true
true
true
7,158
5
DISCUSSION
1
49
[ "bib49", "bib50", "bib51" ]
19,047,440
pmid-17383729|pmid-16651386|pmid-15919902
This may underline a possible role for the complement system in the establishment of immunity in response to YF17D vaccination.
[ "49", "50", "51" ]
127
41,530
0
false
This may underline a possible role for the complement system in the establishment of immunity in response to YF17D vaccination.
[]
This may underline a possible role for the complement system in the establishment of immunity in response to YF17D vaccination.
true
true
true
true
true
7,158
6
DISCUSSION
1
23
[ "bib23", "bib52", "bib53", "bib54" ]
19,047,440
pmid-16461338|pmid-18378159|pmid-17568779|pmid-15963789
The induction of a mixed Th1/Th2 profile by YF17D was suggested by Querec et al., who reported that the vaccine triggers TLR2, 7, 8, and 9 on DCs (23); this was recently confirmed with in vivo data in humans (52).
[ "23", "52", "53", "54" ]
213
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The induction of a mixed Th1/Th2 profile by YF17D was suggested by Querec et al., who reported that the vaccine triggers TLR2, 7, 8, and 9 on DCs ; this was recently confirmed with in vivo data in humans.
[ "23", "52" ]
The induction of a mixed Th1/Th2 profile by YF17D was suggested by Querec et al., who reported that the vaccine triggers TLR2, 7, 8, and 9 on DCs ; this was recently confirmed with in vivo data in humans.
true
true
true
true
true
7,159
6
DISCUSSION
1
23
[ "bib23", "bib52", "bib53", "bib54" ]
19,047,440
pmid-16461338|pmid-18378159|pmid-17568779|pmid-15963789
Our results corroborate these findings; we have demonstrated at the protein level that PBMCs isolated from YF17D-vaccinated volunteers display a mixed T helper cell phenotype.
[ "23", "52", "53", "54" ]
175
41,532
0
false
Our results corroborate these findings; we have demonstrated at the protein level that PBMCs isolated from YF17D-vaccinated volunteers display a mixed T helper cell phenotype.
[]
Our results corroborate these findings; we have demonstrated at the protein level that PBMCs isolated from YF17D-vaccinated volunteers display a mixed T helper cell phenotype.
true
true
true
true
true
7,159
6
DISCUSSION
1
23
[ "bib23", "bib52", "bib53", "bib54" ]
19,047,440
pmid-16461338|pmid-18378159|pmid-17568779|pmid-15963789
Cells from day 60 post-vaccination subjects, when stimulated ex vivo with YF17D-derived peptides, secreted Th1 and Th2 cytokines in their supernatants, as measured by CBA (Fig.
[ "23", "52", "53", "54" ]
176
41,533
0
false
Cells from day 60 post-vaccination subjects, when stimulated ex vivo with YF17D-derived peptides, secreted Th1 and Th2 cytokines in their supernatants, as measured by CBA (Fig.
[]
Cells from day 60 post-vaccination subjects, when stimulated ex vivo with YF17D-derived peptides, secreted Th1 and Th2 cytokines in their supernatants, as measured by CBA (Fig.
true
true
true
true
true
7,159
6
DISCUSSION
1
23
[ "bib23", "bib52", "bib53", "bib54" ]
19,047,440
pmid-16461338|pmid-18378159|pmid-17568779|pmid-15963789
Peptide-stimulated PBMCs from day 28 expressed the Th1 cytokines IL-2 and/or IFN-γ, as revealed by intracellular cytokine staining (Fig.
[ "23", "52", "53", "54" ]
136
41,534
0
false
Peptide-stimulated PBMCs from day 28 expressed the Th1 cytokines IL-2 and/or IFN-γ, as revealed by intracellular cytokine staining (Fig.
[]
Peptide-stimulated PBMCs from day 28 expressed the Th1 cytokines IL-2 and/or IFN-γ, as revealed by intracellular cytokine staining (Fig.
true
true
true
true
true
7,159
6
DISCUSSION
1
23
[ "bib23", "bib52", "bib53", "bib54" ]
19,047,440
pmid-16461338|pmid-18378159|pmid-17568779|pmid-15963789
7 a), and finally, PBMCs from day 365 after vaccination contained central memory T helper cells expressing surface markers typical of Th1 or Th2 cells when stimulated twice with immunostimulatory YF17D peptide pools (Fig.
[ "23", "52", "53", "54" ]
221
41,535
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false
7 a), and finally, PBMCs from day 365 after vaccination contained central memory T helper cells expressing surface markers typical of Th1 or Th2 cells when stimulated twice with immunostimulatory YF17D peptide pools (Fig.
[]
7 a), and finally, PBMCs from day 365 after vaccination contained central memory T helper cells expressing surface markers typical of Th1 or Th2 cells when stimulated twice with immunostimulatory YF17D peptide pools (Fig.
false
false
true
true
false
7,159
6
DISCUSSION
1
53
[ "bib23", "bib52", "bib53", "bib54" ]
19,047,440
pmid-16461338|pmid-18378159|pmid-17568779|pmid-15963789
Induction of the Th2 pathway by a vaccine is essential for the development of humoral immunity; in that context, we noted the induction of several B cell–specific genes in whole blood from volunteers vaccinated with YF17D, including POU2AF1, a transcription factor that is essential for mature B cell differentiation (53...
[ "23", "52", "53", "54" ]
374
41,536
1
false
Induction of the Th2 pathway by a vaccine is essential for the development of humoral immunity; in that context, we noted the induction of several B cell–specific genes in whole blood from volunteers vaccinated with YF17D, including POU2AF1, a transcription factor that is essential for mature B cell differentiation, an...
[ "53" ]
Induction of the Th2 pathway by a vaccine is essential for the development of humoral immunity; in that context, we noted the induction of several B cell–specific genes in whole blood from volunteers vaccinated with YF17D, including POU2AF1, a transcription factor that is essential for mature B cell differentiation, an...
true
true
true
true
true
7,159
6
DISCUSSION
1
54
[ "bib23", "bib52", "bib53", "bib54" ]
19,047,440
pmid-16461338|pmid-18378159|pmid-17568779|pmid-15963789
3 e), which are critical for B cell survival, persistence, and isotype switching (54).
[ "23", "52", "53", "54" ]
86
41,537
1
false
3 e), which are critical for B cell survival, persistence, and isotype switching.
[ "54" ]
3 e), which are critical for B cell survival, persistence, and isotype switching.
false
false
true
true
false
7,159
6
DISCUSSION
1
23
[ "bib23", "bib52", "bib53", "bib54" ]
19,047,440
pmid-16461338|pmid-18378159|pmid-17568779|pmid-15963789
This late induction of B cell–associated genes (days 10 and 14) coincided with the onset of YF17D-specific neutralizing antibody production, which occurred by day 14 in the majority of the vaccinated volunteers (Table S2).
[ "23", "52", "53", "54" ]
222
41,538
0
false
This late induction of B cell–associated genes (days 10 and 14) coincided with the onset of YF17D-specific neutralizing antibody production, which occurred by day 14 in the majority of the vaccinated volunteers (Table S2).
[]
This late induction of B cell–associated genes (days 10 and 14) coincided with the onset of YF17D-specific neutralizing antibody production, which occurred by day 14 in the majority of the vaccinated volunteers.
true
true
true
true
true
7,159
7
DISCUSSION
0
null
null
19,047,440
null
The MIMIC system confirmed that the YF17D vaccine can induce a mixed Th1/Th2 response, as measured by the secretion of the Th1 cytokines IL-2 and IFN-γ, and the Th2 cytokines IL-5 and -13 in the supernatants of the MIMIC co-cultures (Fig.
null
238
41,539
0
false
null
null
The MIMIC system confirmed that the YF17D vaccine can induce a mixed Th1/Th2 response, as measured by the secretion of the Th1 cytokines IL-2 and IFN-γ, and the Th2 cytokines IL-5 and -13 in the supernatants of the MIMIC co-cultures (Fig.
true
true
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true
7,160
7
DISCUSSION
0
null
null
19,047,440
null
8 c), and by the production of IL-5 and -13 (Fig.
null
49
41,540
0
false
null
null
8 c), and by the production of IL-5 and -13 (Fig.
false
false
true
true
false
7,160
7
DISCUSSION
0
null
null
19,047,440
null
8 b) or IFN-γ (Fig.
null
19
41,541
0
false
null
null
8 b) or IFN-γ (Fig.
false
false
true
true
false
7,160
7
DISCUSSION
0
null
null
19,047,440
null
8 a) by antigen-specific CD154+ T helper cells.
null
47
41,542
0
false
null
null
8 a) by antigen-specific CD154+ T helper cells.
false
false
true
true
false
7,160
7
DISCUSSION
0
null
null
19,047,440
null
The observation that both live and UV-inactivated YF17D virus stimulate an identical response clearly shows that viral replication is not required for the induction of adaptive immunity.
null
186
41,543
0
false
null
null
The observation that both live and UV-inactivated YF17D virus stimulate an identical response clearly shows that viral replication is not required for the induction of adaptive immunity.
true
true
true
true
true
7,160
7
DISCUSSION
0
null
null
19,047,440
null
Importantly, we show by gene array that most of the transcriptional nodes involved in the response to YF17D in vivo that were identified with the Montreal cohort (Fig.
null
167
41,544
0
false
null
null
Importantly, we show by gene array that most of the transcriptional nodes involved in the response to YF17D in vivo that were identified with the Montreal cohort (Fig.
true
true
true
true
true
7,160
7
DISCUSSION
0
null
null
19,047,440
null
2) are also induced in the Lausanne cohort, as well as in the in vitro MIMIC system (Table S3), leading to the mobilization of several of their downstream transcriptional targets.
null
179
41,545
0
false
null
null
2) are also induced in the Lausanne cohort, as well as in the in vitro MIMIC system (Table S3), leading to the mobilization of several of their downstream transcriptional targets.
false
false
true
true
false
7,160
7
DISCUSSION
0
null
null
19,047,440
null
Specifically, we found that immunization with YF17D elicits the induction of IRF1, IRF7, IRF8, STAT1, and FOXO3a in all three datasets, all of which are masterswitch genes required for the coordination of an efficient and protective immune response.
null
249
41,546
0
false
null
null
Specifically, we found that immunization with YF17D elicits the induction of IRF1, IRF7, IRF8, STAT1, and FOXO3a in all three datasets, all of which are masterswitch genes required for the coordination of an efficient and protective immune response.
true
true
true
true
true
7,160
7
DISCUSSION
0
null
null
19,047,440
null
Moreover, ICA followed by gene set enrichment (Table S4, available at http://www.jem.org/cgi/content/full/jem.20082292/DC1) has revealed a significant enrichment of genes induced by IFNs and viruses among the three datasets, namely those from Montreal, Lausanne, and VaxDesign's MIMIC system.
null
292
41,547
0
false
null
null
Moreover, ICA followed by gene set enrichment (Table S4, available at http://www.jem.org/cgi/content/full/jem.20082292/DC1) has revealed a significant enrichment of genes induced by IFNs and viruses among the three datasets, namely those from Montreal, Lausanne, and VaxDesign's MIMIC system.
true
true
true
true
true
7,160
8
DISCUSSION
1
55
[ "bib55", "bib42", "bib56", "bib57" ]
19,047,440
pmid-17898760|pmid-18288107|pmid-14978071|pmid-15661881
Our results highlight the critical role of innate immunity in the elicitation of the multilineage and broad immune responses observed herein, and demonstrate the complexity of the innate immune response that is generated upon vaccination with YF17D.
[ "55", "42", "56", "57" ]
249
41,548
0
false
Our results highlight the critical role of innate immunity in the elicitation of the multilineage and broad immune responses observed herein, and demonstrate the complexity of the innate immune response that is generated upon vaccination with YF17D.
[]
Our results highlight the critical role of innate immunity in the elicitation of the multilineage and broad immune responses observed herein, and demonstrate the complexity of the innate immune response that is generated upon vaccination with YF17D.
true
true
true
true
true
7,161
8
DISCUSSION
1
55
[ "bib55", "bib42", "bib56", "bib57" ]
19,047,440
pmid-17898760|pmid-18288107|pmid-14978071|pmid-15661881
Indeed, several effector molecules of the innate immune response, including complement, IFNs, the inflammasome, and several effector cells of innate immunity (i.e., macrophages, NK cells, and DCs, the latter being most likely the producers of type
[ "55", "42", "56", "57" ]
247
41,549
0
false
Indeed, several effector molecules of the innate immune response, including complement, IFNs, the inflammasome, and several effector cells of innate immunity (i.e., macrophages, NK cells, and DCs, the latter being most likely the producers of type
[]
Indeed, several effector molecules of the innate immune response, including complement, IFNs, the inflammasome, and several effector cells of innate immunity (i.e., macrophages, NK cells, and DCs, the latter being most likely the producers of type
true
true
false
true
false
7,161
8
DISCUSSION
1
55
[ "bib55", "bib42", "bib56", "bib57" ]
19,047,440
pmid-17898760|pmid-18288107|pmid-14978071|pmid-15661881
I IFNs [55]), are involved in this early response (day 3 and 7).
[ "55", "42", "56", "57" ]
64
41,550
1
false
I IFNs ), are involved in this early response (day 3 and 7).
[ "55" ]
I IFNs ), are involved in this early response (day 3 and 7).
true
true
true
true
true
7,161
8
DISCUSSION
1
55
[ "bib55", "bib42", "bib56", "bib57" ]
19,047,440
pmid-17898760|pmid-18288107|pmid-14978071|pmid-15661881
Control of viral replication (Table S5, available at http://www.jem.org/cgi/content/full/jem.20082292/DC1) happens as this innate response precedes the emergence of YF17D-specific humoral and cellular immune responses.
[ "55", "42", "56", "57" ]
218
41,551
0
false
Control of viral replication (Table S5, available at http://www.jem.org/cgi/content/full/jem.20082292/DC1) happens as this innate response precedes the emergence of YF17D-specific humoral and cellular immune responses.
[]
Control of viral replication happens as this innate response precedes the emergence of YF17D-specific humoral and cellular immune responses.
true
true
true
true
true
7,161
8
DISCUSSION
1
42
[ "bib55", "bib42", "bib56", "bib57" ]
19,047,440
pmid-17898760|pmid-18288107|pmid-14978071|pmid-15661881
Interestingly, complement, IFNs, and the inflammasome can all impact on the quality of the adaptive immune response and trigger Th1/Th2 mixed immune responses (42).
[ "55", "42", "56", "57" ]
164
41,552
1
false
Interestingly, complement, IFNs, and the inflammasome can all impact on the quality of the adaptive immune response and trigger Th1/Th2 mixed immune responses.
[ "42" ]
Interestingly, complement, IFNs, and the inflammasome can all impact on the quality of the adaptive immune response and trigger Th1/Th2 mixed immune responses.
true
true
true
true
true
7,161
8
DISCUSSION
1
56
[ "bib55", "bib42", "bib56", "bib57" ]
19,047,440
pmid-17898760|pmid-18288107|pmid-14978071|pmid-15661881
Notably, YF17D triggers TLR2, which is upstream of the Th2 pathway (56) and TLR7, 8, and 9, which trigger mostly the Th1 pathway (57).
[ "55", "42", "56", "57" ]
134
41,553
1
false
Notably, YF17D triggers TLR2, which is upstream of the Th2 pathway and TLR7, 8, and 9, which trigger mostly the Th1 pathway.
[ "56", "57" ]
Notably, YF17D triggers TLR2, which is upstream of the Th2 pathway and TLR7, 8, and 9, which trigger mostly the Th1 pathway.
true
true
true
true
true
7,161
8
DISCUSSION
1
55
[ "bib55", "bib42", "bib56", "bib57" ]
19,047,440
pmid-17898760|pmid-18288107|pmid-14978071|pmid-15661881
Our studies have also revealed that the mixed Th1/Th2 CD4+ response preceded B cell responses, as monitored by the detection of antibodies in serum of vaccinated subjects and the identification of gene expression signatures specific to B cell responses (Table S2 and Fig.
[ "55", "42", "56", "57" ]
271
41,554
0
false
Our studies have also revealed that the mixed Th1/Th2 CD4+ response preceded B cell responses, as monitored by the detection of antibodies in serum of vaccinated subjects and the identification of gene expression signatures specific to B cell responses (Table S2 and Fig.
[]
Our studies have also revealed that the mixed Th1/Th2 CD4+ response preceded B cell responses, as monitored by the detection of antibodies in serum of vaccinated subjects and the identification of gene expression signatures specific to B cell responses (Table S2 and Fig.
true
true
true
true
true
7,161
8
DISCUSSION
1
55
[ "bib55", "bib42", "bib56", "bib57" ]
19,047,440
pmid-17898760|pmid-18288107|pmid-14978071|pmid-15661881
An important outcome of the early development of Th2 memory CD4+ T cells is the generation and persistence of a strong antibody response.
[ "55", "42", "56", "57" ]
137
41,555
0
false
An important outcome of the early development of Th2 memory CD4+ T cells is the generation and persistence of a strong antibody response.
[]
An important outcome of the early development of Th2 memory CD4+ T cells is the generation and persistence of a strong antibody response.
true
true
true
true
true
7,161
8
DISCUSSION
1
55
[ "bib55", "bib42", "bib56", "bib57" ]
19,047,440
pmid-17898760|pmid-18288107|pmid-14978071|pmid-15661881
As for CD8+ responses, they could certainly be involved in providing long lasting protection against reexposure to the virus.
[ "55", "42", "56", "57" ]
125
41,556
0
false
As for CD8+ responses, they could certainly be involved in providing long lasting protection against reexposure to the virus.
[]
As for CD8+ responses, they could certainly be involved in providing long lasting protection against reexposure to the virus.
true
true
true
true
true
7,161
8
DISCUSSION
1
55
[ "bib55", "bib42", "bib56", "bib57" ]
19,047,440
pmid-17898760|pmid-18288107|pmid-14978071|pmid-15661881
In that context, it will be important to compare the immune response described herein to that of individuals that have been reexposed to the virus, such as those who live in endemic areas or who get reimmunized with the vaccine.
[ "55", "42", "56", "57" ]
228
41,557
0
false
In that context, it will be important to compare the immune response described herein to that of individuals that have been reexposed to the virus, such as those who live in endemic areas or who get reimmunized with the vaccine.
[]
In that context, it will be important to compare the immune response described herein to that of individuals that have been reexposed to the virus, such as those who live in endemic areas or who get reimmunized with the vaccine.
true
true
true
true
true
7,161
9
DISCUSSION
0
null
null
19,047,440
null
The results described herein identify unique features of protective immune responses which can now be used as benchmarks to design and monitor the development of novel vaccines.
null
177
41,558
0
false
null
null
The results described herein identify unique features of protective immune responses which can now be used as benchmarks to design and monitor the development of novel vaccines.
true
true
true
true
true
7,162
9
DISCUSSION
0
null
null
19,047,440
null
They demonstrate the complexity of this immune response and they highlight the fact that it is the sum of all arms of the immune response that is most probably required for the long-lasting protection induced by this vaccine; and they highlight the fact that it is this integrated immune response that constitutes the co...
null
343
41,559
0
false
null
null
They demonstrate the complexity of this immune response and they highlight the fact that it is the sum of all arms of the immune response that is most probably required for the long-lasting protection induced by this vaccine; and they highlight the fact that it is this integrated immune response that constitutes the co...
true
true
true
true
true
7,162
9
DISCUSSION
0
null
null
19,047,440
null
In that context, systems biology becomes an essential tool to identify correlates of immune-mediated protection.
null
112
41,560
0
false
null
null
In that context, systems biology becomes an essential tool to identify correlates of immune-mediated protection.
true
true
true
true
true
7,162
9
DISCUSSION
0
null
null
19,047,440
null
The recent failure of the STEP HIV vaccine trial paves the way for the use of new immune monitoring strategies focused on the identification of multilineage and polyfunctional features of candidate vaccine-induced immune response.
null
230
41,561
0
false
null
null
The recent failure of the STEP HIV vaccine trial paves the way for the use of new immune monitoring strategies focused on the identification of multilineage and polyfunctional features of candidate vaccine-induced immune response.
true
true
true
true
true
7,162
0
DISCUSSION
1
1
[ "CIT1", "CIT2", "CIT2", "CIT2" ]
20,924,458
NA|pmid-4353020|pmid-4353020|pmid-4353020
Lipoblastoma is a rare benign tumour of embryonal fat.
[ "1", "2", "2", "2" ]
54
41,562
0
false
Lipoblastoma is a rare benign tumour of embryonal fat.
[]
Lipoblastoma is a rare benign tumour of embryonal fat.
true
true
true
true
true
7,163
0
DISCUSSION
1
1
[ "CIT1", "CIT2", "CIT2", "CIT2" ]
20,924,458
NA|pmid-4353020|pmid-4353020|pmid-4353020
first introduced the term lipoblastoma in 1926 to describe a tumour of immature fat.
[ "1", "2", "2", "2" ]
84
41,563
0
false
first introduced the term lipoblastoma in 1926 to describe a tumour of immature fat.
[]
first introduced the term lipoblastoma in 1926 to describe a tumour of immature fat.
false
true
true
true
false
7,163
0
DISCUSSION
1
2
[ "CIT1", "CIT2", "CIT2", "CIT2" ]
20,924,458
NA|pmid-4353020|pmid-4353020|pmid-4353020
Chung and Enzinger[2] described two forms – the term lipoblastoma for the localised circumscribed type and lipoblastomatosis for the diffuse multicentric variant.
[ "1", "2", "2", "2" ]
162
41,564
1
false
Chung and Enzinger described two forms – the term lipoblastoma for the localised circumscribed type and lipoblastomatosis for the diffuse multicentric variant.
[ "2" ]
Chung and Enzinger described two forms – the term lipoblastoma for the localised circumscribed type and lipoblastomatosis for the diffuse multicentric variant.
true
true
true
true
true
7,163
0
DISCUSSION
1
1
[ "CIT1", "CIT2", "CIT2", "CIT2" ]
20,924,458
NA|pmid-4353020|pmid-4353020|pmid-4353020
It occurs more exclusively in infants and children, with 90% of the cases in children <3 years of age.
[ "1", "2", "2", "2" ]
102
41,565
0
false
It occurs more exclusively in infants and children, with 90% of the cases in children <3 years of age.
[]
It occurs more exclusively in infants and children, with 90% of the cases in children <3 years of age.
true
true
true
true
true
7,163
0
DISCUSSION
1
1
[ "CIT1", "CIT2", "CIT2", "CIT2" ]
20,924,458
NA|pmid-4353020|pmid-4353020|pmid-4353020
It shows a male preponderance (3:1).
[ "1", "2", "2", "2" ]
36
41,566
0
false
It shows a male preponderance.
[ "3:1" ]
It shows a male preponderance.
true
true
true
true
true
7,163
0
DISCUSSION
1
1
[ "CIT1", "CIT2", "CIT2", "CIT2" ]
20,924,458
NA|pmid-4353020|pmid-4353020|pmid-4353020
Lipoblastomas commonly arise from the extremities (36–72%), trunk (20–50%) and in the head and neck (10–l5%).
[ "1", "2", "2", "2" ]
109
41,567
0
false
Lipoblastomas commonly arise from the extremities, trunk and in the head and neck.
[ "36–72%", "20–50%", "10–l5%" ]
Lipoblastomas commonly arise from the extremities, trunk and in the head and neck.
true
true
true
true
true
7,163
1
DISCUSSION
0
null
null
20,924,458
null
To date, 34 cases of cervical lipoblastomas have been described in the English literature.
null
90
41,568
0
false
null
null
To date, 34 cases of cervical lipoblastomas have been described in the English literature.
true
true
true
true
true
7,164
2
DISCUSSION
1
3
[ "CIT3" ]
20,924,458
pmid-3429147
Only two cases of lipoblastoma arising from the salivary gland have been described so far.
[ "3" ]
90
41,569
0
false
Only two cases of lipoblastoma arising from the salivary gland have been described so far.
[]
Only two cases of lipoblastoma arising from the salivary gland have been described so far.
true
true
true
true
true
7,165
2
DISCUSSION
1
3
[ "CIT3" ]
20,924,458
pmid-3429147
Calhoun et al.
[ "3" ]
14
41,570
0
false
Calhoun et al.
[]
Calhoun et al.
true
true
true
true
true
7,165
2
DISCUSSION
1
3
[ "CIT3" ]
20,924,458
pmid-3429147
[3] reported a parotid lipoblastoma involving the superficial lobe of a 7-month-old male infant.
[ "3" ]
96
41,571
1
false
reported a parotid lipoblastoma involving the superficial lobe of a 7-month-old male infant.
[ "3" ]
reported a parotid lipoblastoma involving the superficial lobe of a 7-month-old male infant.
false
true
true
true
false
7,165
3
DISCUSSION
1
4
[ "CIT4" ]
20,924,458
pmid-9419158
Krempl et al.,[4] in 1997, described lipoblastoma arising from the deep lobe of the parotid in a 13-month-old male infant.
[ "4" ]
122
41,572
1
false
Krempl et al., in 1997, described lipoblastoma arising from the deep lobe of the parotid in a 13-month-old male infant.
[ "4" ]
Krempl et al., in 1997, described lipoblastoma arising from the deep lobe of the parotid in a 13-month-old male infant.
true
true
true
true
true
7,166
4
DISCUSSION
1
5
[ "CIT5" ]
20,924,458
pmid-7108715
In the cervical region, the most common presentation is a rapidly growing painless mass.
[ "5" ]
88
41,573
0
false
In the cervical region, the most common presentation is a rapidly growing painless mass.
[]
In the cervical region, the most common presentation is a rapidly growing painless mass.
true
true
true
true
true
7,167
4
DISCUSSION
1
5
[ "CIT5" ]
20,924,458
pmid-7108715
Imaging studies have been used pre-operatively to assess the lesion.
[ "5" ]
68
41,574
0
false
Imaging studies have been used pre-operatively to assess the lesion.
[]
Imaging studies have been used pre-operatively to assess the lesion.
true
true
true
true
true
7,167
4
DISCUSSION
1
5
[ "CIT5" ]
20,924,458
pmid-7108715
CT scan usually shows a lesion in which the Hounsfield density is consistent with fat[5]
[ "5" ]
88
41,575
1
false
CT scan usually shows a lesion in which the Hounsfield density is consistent with fat
[ "5" ]
CT scan usually shows a lesion in which the Hounsfield density is consistent with fat
true
true
false
true
false
7,167
4
DISCUSSION
1
5
[ "CIT5" ]
20,924,458
pmid-7108715
(HU –50 to –75).
[ "5" ]
16
41,576
0
false
.
[ "HU –50 to –75" ]
.
false
false
true
true
false
7,167
5
DISCUSSION
1
6
[ "CIT6" ]
20,924,458
pmid-10398794
MRI shows a hyperintense image on T1-weighted and T2-weighted sequences, but shows lower signal intensity than mature fat tissue (lipoma) on T1-weighted images.
[ "6" ]
160
41,577
0
false
MRI shows a hyperintense image on T1-weighted and T2-weighted sequences, but shows lower signal intensity than mature fat tissue (lipoma) on T1-weighted images.
[]
MRI shows a hyperintense image on T1-weighted and T2-weighted sequences, but shows lower signal intensity than mature fat tissue (lipoma) on T1-weighted images.
true
true
true
true
true
7,168
5
DISCUSSION
1
6
[ "CIT6" ]
20,924,458
pmid-10398794
The fibrous septae appear hypointense, making the tumour homogeneous.
[ "6" ]
69
41,578
0
false
The fibrous septae appear hypointense, making the tumour homogeneous.
[]
The fibrous septae appear hypointense, making the tumour homogeneous.
true
true
true
true
true
7,168
5
DISCUSSION
1
6
[ "CIT6" ]
20,924,458
pmid-10398794
The high signal intensity on the T2-weighted sequence may be caused by the rich myxoid stroma with numerous lipoblasts.
[ "6" ]
119
41,579
0
false
The high signal intensity on the T2-weighted sequence may be caused by the rich myxoid stroma with numerous lipoblasts.
[]
The high signal intensity on the T2-weighted sequence may be caused by the rich myxoid stroma with numerous lipoblasts.
true
true
true
true
true
7,168
5
DISCUSSION
1
6
[ "CIT6" ]
20,924,458
pmid-10398794
However, none of these findings are diagnostic of lipoblastomas because all these features can be observed in many benign and malignant fatty tumours.
[ "6" ]
150
41,580
0
false
However, none of these findings are diagnostic of lipoblastomas because all these features can be observed in many benign and malignant fatty tumours.
[]
However, none of these findings are diagnostic of lipoblastomas because all these features can be observed in many benign and malignant fatty tumours.
true
true
true
true
true
7,168
5
DISCUSSION
1
6
[ "CIT6" ]
20,924,458
pmid-10398794
MRI is particularly useful for follow-up and evaluation of recurrent lesions.
[ "6" ]
77
41,581
0
false
MRI is particularly useful for follow-up and evaluation of recurrent lesions.
[]
MRI is particularly useful for follow-up and evaluation of recurrent lesions.
true
true
true
true
true
7,168
6
DISCUSSION
1
7
[ "CIT7" ]
20,924,458
NA
Lipoma, hibernoma, liposarcoma and embryonal rhabdomyosarcoma are considered in the differential diagnosis of a lipoblastoma.
[ "7" ]
125
41,582
0
false
Lipoma, hibernoma, liposarcoma and embryonal rhabdomyosarcoma are considered in the differential diagnosis of a lipoblastoma.
[]
Lipoma, hibernoma, liposarcoma and embryonal rhabdomyosarcoma are considered in the differential diagnosis of a lipoblastoma.
true
true
true
true
true
7,169
6
DISCUSSION
1
7
[ "CIT7" ]
20,924,458
NA
Histologically, lipoblastomas consist of lobulated adipose tissue with fibrous septae with myxoid stroma and immature lipoblasts.
[ "7" ]
129
41,583
0
false
Histologically, lipoblastomas consist of lobulated adipose tissue with fibrous septae with myxoid stroma and immature lipoblasts.
[]
Histologically, lipoblastomas consist of lobulated adipose tissue with fibrous septae with myxoid stroma and immature lipoblasts.
true
true
true
true
true
7,169
6
DISCUSSION
1
7
[ "CIT7" ]
20,924,458
NA
Lipomas have lobules with fibrous septae, but lack lipoblasts.
[ "7" ]
62
41,584
0
false
Lipomas have lobules with fibrous septae, but lack lipoblasts.
[]
Lipomas have lobules with fibrous septae, but lack lipoblasts.
true
true
true
true
true
7,169
6
DISCUSSION
1
7
[ "CIT7" ]
20,924,458
NA
Hibernomas also have a lobular pattern, but consist entirely of brown fat cells with eosinophilic granular cytoplasm.
[ "7" ]
117
41,585
0
false
Hibernomas also have a lobular pattern, but consist entirely of brown fat cells with eosinophilic granular cytoplasm.
[]
Hibernomas also have a lobular pattern, but consist entirely of brown fat cells with eosinophilic granular cytoplasm.
true
true
true
true
true
7,169
7
DISCUSSION
1
8
[ "CIT8" ]
20,924,458
pmid-1521225
Recent cytogenetic analysis revealed specific chromosomal abnormalities in adipose tissue tumours, which may aid in accurate diagnosis.
[ "8" ]
135
41,586
0
false
Recent cytogenetic analysis revealed specific chromosomal abnormalities in adipose tissue tumours, which may aid in accurate diagnosis.
[]
Recent cytogenetic analysis revealed specific chromosomal abnormalities in adipose tissue tumours, which may aid in accurate diagnosis.
true
true
true
true
true
7,170
7
DISCUSSION
1
8
[ "CIT8" ]
20,924,458
pmid-1521225
Cytogenetic breakpoint abnormalities[8] occur consistently in the chromosome 8q11-13 in lipoblastomas affecting PLAG1.
[ "8" ]
118
41,587
1
false
Cytogenetic breakpoint abnormalities occur consistently in the chromosome 8q11-13 in lipoblastomas affecting PLAG1.
[ "8" ]
Cytogenetic breakpoint abnormalities occur consistently in the chromosome 8q11-13 in lipoblastomas affecting PLAG1.
true
true
true
true
true
7,170
8
DISCUSSION
1
9
[ "CIT9" ]
20,924,458
pmid-10559671
Leptin is a hormone that is produced by adipocytes.
[ "9" ]
51
41,588
0
false
Leptin is a hormone that is produced by adipocytes.
[]
Leptin is a hormone that is produced by adipocytes.
true
true
true
true
true
7,171
8
DISCUSSION
1
9
[ "CIT9" ]
20,924,458
pmid-10559671
Leptin and leptin receptors are found in lipoblastomas.
[ "9" ]
55
41,589
0
false
Leptin and leptin receptors are found in lipoblastomas.
[]
Leptin and leptin receptors are found in lipoblastomas.
true
true
true
true
true
7,171
8
DISCUSSION
1
9
[ "CIT9" ]
20,924,458
pmid-10559671
Deutscher et al.
[ "9" ]
16
41,590
0
false
Deutscher et al.
[]
Deutscher et al.
true
true
true
true
true
7,171
8
DISCUSSION
1
9
[ "CIT9" ]
20,924,458
pmid-10559671
proposed a hypothesis that the peripheral action of leptin via its receptors could play a role in the development and/or progression of lipoblastoma.
[ "9" ]
149
41,591
0
false
proposed a hypothesis that the peripheral action of leptin via its receptors could play a role in the development and/or progression of lipoblastoma.
[]
proposed a hypothesis that the peripheral action of leptin via its receptors could play a role in the development and/or progression of lipoblastoma.
false
true
true
true
false
7,171
9
DISCUSSION
0
null
null
20,924,458
null
Complete surgical excision is the treatment of choice.
null
54
41,592
0
false
null
null
Complete surgical excision is the treatment of choice.
true
true
true
true
true
7,172
9
DISCUSSION
0
null
null
20,924,458
null
Incomplete excision would result in recurrence.
null
47
41,593
0
false
null
null
Incomplete excision would result in recurrence.
true
true
true
true
true
7,172
9
DISCUSSION
0
null
null
20,924,458
null
Hence, careful follow-up is essential for at least a period of 2 years.
null
71
41,594
0
false
null
null
Hence, careful follow-up is essential for at least a period of 2 years.
true
true
true
true
true
7,172
9
DISCUSSION
0
null
null
20,924,458
null
Three years follow-up in our patient did not reveal any recurrence [Figure 10].
null
79
41,595
0
false
null
null
Three years follow-up in our patient did not reveal any recurrence [Figure 10].
true
true
true
true
true
7,172
10
DISCUSSION
0
null
null
20,924,458
null
Three-year postoperative picture
null
32
41,596
0
false
null
null
Three-year postoperative picture
true
true
false
true
false
7,173
0
INTRODUCTION
1
1
[ "B1", "B2 B3 B4 B5" ]
18,676,978
NA|pmid-15269332|pmid-17105995|pmid-12955455|pmid-17295027|pmid-14960277|pmid-12080340|pmid-17217467|pmid-16326926
Plant mitochondrial and chloroplast genomes encode ∼50 and ∼100 products, respectively, most of which participate in basal organellar gene expression or energy transduction.
[ "1", "2–5" ]
173
41,597
0
false
Plant mitochondrial and chloroplast genomes encode ∼50 and ∼100 products, respectively, most of which participate in basal organellar gene expression or energy transduction.
[]
Plant mitochondrial and chloroplast genomes encode ∼50 and ∼100 products, respectively, most of which participate in basal organellar gene expression or energy transduction.
true
true
true
true
true
7,174
0
INTRODUCTION
1
1
[ "B1", "B2 B3 B4 B5" ]
18,676,978
NA|pmid-15269332|pmid-17105995|pmid-12955455|pmid-17295027|pmid-14960277|pmid-12080340|pmid-17217467|pmid-16326926
Post-transcriptional events play the dominant role in dictating gene product abundance in both organelles (1).
[ "1", "2–5" ]
110
41,598
1
false
Post-transcriptional events play the dominant role in dictating gene product abundance in both organelles.
[ "1" ]
Post-transcriptional events play the dominant role in dictating gene product abundance in both organelles.
true
true
true
true
true
7,174
0
INTRODUCTION
1
1
[ "B1", "B2 B3 B4 B5" ]
18,676,978
NA|pmid-15269332|pmid-17105995|pmid-12955455|pmid-17295027|pmid-14960277|pmid-12080340|pmid-17217467|pmid-16326926
In fact, the two organelles house a similar repertoire of RNA-processing pathways that includes RNA editing, group II intron splicing and endonucleolytic processing.
[ "1", "2–5" ]
165
41,599
0
false
In fact, the two organelles house a similar repertoire of RNA-processing pathways that includes RNA editing, group II intron splicing and endonucleolytic processing.
[]
In fact, the two organelles house a similar repertoire of RNA-processing pathways that includes RNA editing, group II intron splicing and endonucleolytic processing.
true
true
true
true
true
7,174
0
INTRODUCTION
1
2–5
[ "B1", "B2 B3 B4 B5" ]
18,676,978
NA|pmid-15269332|pmid-17105995|pmid-12955455|pmid-17295027|pmid-14960277|pmid-12080340|pmid-17217467|pmid-16326926
Genetic and bioinformatic analyses suggest that many hundreds of nuclear genes encode organelle-localized nucleic acid binding proteins and influence organellar gene expression (2–5), but only a small fraction of such genes has been studied.
[ "1", "2–5" ]
241
41,600
1
false
Genetic and bioinformatic analyses suggest that many hundreds of nuclear genes encode organelle-localized nucleic acid binding proteins and influence organellar gene expression, but only a small fraction of such genes has been studied.
[ "2–5" ]
Genetic and bioinformatic analyses suggest that many hundreds of nuclear genes encode organelle-localized nucleic acid binding proteins and influence organellar gene expression, but only a small fraction of such genes has been studied.
true
true
true
true
true
7,174
1
INTRODUCTION
1
6–15
[ "B6 B7 B8 B9 B10 B11 B12 B13 B14 B15", "B6", "B9", "B10", "B11", "B16" ]
18,676,978
pmid-9090875|pmid-11179231|pmid-18065687|pmid-17071648|pmid-12881426|pmid-11565746|pmid-17693527|NA|NA|pmid-17041147|pmid-9090875|pmid-17071648|pmid-12881426|pmid-11565746|pmid-15598799
The protein that is the focus of this study, ZmWHY1, came to our attention during our characterization of the chloroplast RNA splicing machinery.
[ "6–15", "6", "9", "10", "11", "16" ]
145
41,601
0
false
The protein that is the focus of this study, ZmWHY1, came to our attention during our characterization of the chloroplast RNA splicing machinery.
[]
The protein that is the focus of this study, ZmWHY1, came to our attention during our characterization of the chloroplast RNA splicing machinery.
true
true
true
true
true
7,175
1
INTRODUCTION
1
6–15
[ "B6 B7 B8 B9 B10 B11 B12 B13 B14 B15", "B6", "B9", "B10", "B11", "B16" ]
18,676,978
pmid-9090875|pmid-11179231|pmid-18065687|pmid-17071648|pmid-12881426|pmid-11565746|pmid-17693527|NA|NA|pmid-17041147|pmid-9090875|pmid-17071648|pmid-12881426|pmid-11565746|pmid-15598799
Nine nucleus-encoded proteins that are necessary for the splicing of various subsets of the ∼20 chloroplast introns in vascular plants have been reported (6–15).
[ "6–15", "6", "9", "10", "11", "16" ]
161
41,602
1
false
Nine nucleus-encoded proteins that are necessary for the splicing of various subsets of the ∼20 chloroplast introns in vascular plants have been reported.
[ "6–15" ]
Nine nucleus-encoded proteins that are necessary for the splicing of various subsets of the ∼20 chloroplast introns in vascular plants have been reported.
true
true
true
true
true
7,175
1
INTRODUCTION
1
6–15
[ "B6 B7 B8 B9 B10 B11 B12 B13 B14 B15", "B6", "B9", "B10", "B11", "B16" ]
18,676,978
pmid-9090875|pmid-11179231|pmid-18065687|pmid-17071648|pmid-12881426|pmid-11565746|pmid-17693527|NA|NA|pmid-17041147|pmid-9090875|pmid-17071648|pmid-12881426|pmid-11565746|pmid-15598799
One of the first to be characterized, CRS1, is necessary for the splicing of the group II intron in the chloroplast atpF gene (6,9), and binds specifically to that intron in vivo and in vitro (10,11,16).
[ "6–15", "6", "9", "10", "11", "16" ]
203
41,603
0
false
One of the first to be characterized, CRS1, is necessary for the splicing of the group II intron in the chloroplast atpF gene, and binds specifically to that intron in vivo and in vitro.
[ "6,9", "10,11,16" ]
One of the first to be characterized, CRS1, is necessary for the splicing of the group II intron in the chloroplast atpF gene, and binds specifically to that intron in vivo and in vitro.
true
true
true
true
true
7,175
1
INTRODUCTION
1
6–15
[ "B6 B7 B8 B9 B10 B11 B12 B13 B14 B15", "B6", "B9", "B10", "B11", "B16" ]
18,676,978
pmid-9090875|pmid-11179231|pmid-18065687|pmid-17071648|pmid-12881426|pmid-11565746|pmid-17693527|NA|NA|pmid-17041147|pmid-9090875|pmid-17071648|pmid-12881426|pmid-11565746|pmid-15598799
However, the large size of the particles containing CRS1 and atpF intron RNA in vivo, and the fact that CRS1 is not sufficient to promote atpF intron splicing in vitro suggested that additional proteins are involved.
[ "6–15", "6", "9", "10", "11", "16" ]
216
41,604
0
false
However, the large size of the particles containing CRS1 and atpF intron RNA in vivo, and the fact that CRS1 is not sufficient to promote atpF intron splicing in vitro suggested that additional proteins are involved.
[]
However, the large size of the particles containing CRS1 and atpF intron RNA in vivo, and the fact that CRS1 is not sufficient to promote atpF intron splicing in vitro suggested that additional proteins are involved.
true
true
true
true
true
7,175
1
INTRODUCTION
1
6–15
[ "B6 B7 B8 B9 B10 B11 B12 B13 B14 B15", "B6", "B9", "B10", "B11", "B16" ]
18,676,978
pmid-9090875|pmid-11179231|pmid-18065687|pmid-17071648|pmid-12881426|pmid-11565746|pmid-17693527|NA|NA|pmid-17041147|pmid-9090875|pmid-17071648|pmid-12881426|pmid-11565746|pmid-15598799
We therefore used mass spectrometry to identify proteins that coimmunoprecipitate with CRS1; ZmWHY1 was one such protein.
[ "6–15", "6", "9", "10", "11", "16" ]
121
41,605
0
false
We therefore used mass spectrometry to identify proteins that coimmunoprecipitate with CRS1; ZmWHY1 was one such protein.
[]
We therefore used mass spectrometry to identify proteins that coimmunoprecipitate with CRS1; ZmWHY1 was one such protein.
true
true
true
true
true
7,175
2
INTRODUCTION
1
17
[ "B17", "B18", "B17", "B19", "B20", "B21", "B22", "B23" ]
18,676,978
pmid-14960277|pmid-10948264|pmid-14960277|pmid-12080340|pmid-17217467|pmid-15967440|pmid-16326926|pmid-18423020|pmid-11565746|NA|pmid-15891117|pmid-15010617|pmid-15197595|pmid-12678554
ZmWHY1 is a member of the ‘Whirly’ protein family, whose orthologs in potato (StWHY1) and Arabidopsis (AtWHY1) were reported to be nuclear transcription factors involved in pathogen-induced transcription (17,18).
[ "17", "18", "17", "19", "20", "21", "22", "23" ]
212
41,606
0
false
ZmWHY1 is a member of the ‘Whirly’ protein family, whose orthologs in potato (StWHY1) and Arabidopsis (AtWHY1) were reported to be nuclear transcription factors involved in pathogen-induced transcription.
[ "17,18" ]
ZmWHY1 is a member of the ‘Whirly’ protein family, whose orthologs in potato and Arabidopsis were reported to be nuclear transcription factors involved in pathogen-induced transcription.
true
true
true
true
true
7,176
2
INTRODUCTION
1
17
[ "B17", "B18", "B17", "B19", "B20", "B21", "B22", "B23" ]
18,676,978
pmid-14960277|pmid-10948264|pmid-14960277|pmid-12080340|pmid-17217467|pmid-15967440|pmid-16326926|pmid-18423020|pmid-11565746|NA|pmid-15891117|pmid-15010617|pmid-15197595|pmid-12678554
StWHY1 and AtWHY1 bind single-stranded DNA (ssDNA) in vitro, and StWHY1 adopts a propeller-like structure from which the family acquired its name (17,19).
[ "17", "18", "17", "19", "20", "21", "22", "23" ]
154
41,607
0
false
StWHY1 and AtWHY1 bind single-stranded DNA (ssDNA) in vitro, and StWHY1 adopts a propeller-like structure from which the family acquired its name.
[ "17,19" ]
StWHY1 and AtWHY1 bind single-stranded DNA (ssDNA) in vitro, and StWHY1 adopts a propeller-like structure from which the family acquired its name.
true
true
true
true
true
7,176
2
INTRODUCTION
1
20
[ "B17", "B18", "B17", "B19", "B20", "B21", "B22", "B23" ]
18,676,978
pmid-14960277|pmid-10948264|pmid-14960277|pmid-12080340|pmid-17217467|pmid-15967440|pmid-16326926|pmid-18423020|pmid-11565746|NA|pmid-15891117|pmid-15010617|pmid-15197595|pmid-12678554
AtWHY1 has also been implicated in telomere binding and maintenance (20).
[ "17", "18", "17", "19", "20", "21", "22", "23" ]
73
41,608
1
false
AtWHY1 has also been implicated in telomere binding and maintenance.
[ "20" ]
AtWHY1 has also been implicated in telomere binding and maintenance.
true
true
true
true
true
7,176
2
INTRODUCTION
1
21
[ "B17", "B18", "B17", "B19", "B20", "B21", "B22", "B23" ]
18,676,978
pmid-14960277|pmid-10948264|pmid-14960277|pmid-12080340|pmid-17217467|pmid-15967440|pmid-16326926|pmid-18423020|pmid-11565746|NA|pmid-15891117|pmid-15010617|pmid-15197595|pmid-12678554
Additional functions for members of the Whirly family were suggested by the fact that GFP fused to each member of the family from Arabidopsis localizes to chloroplasts or mitochondria (21).
[ "17", "18", "17", "19", "20", "21", "22", "23" ]
189
41,609
1
false
Additional functions for members of the Whirly family were suggested by the fact that GFP fused to each member of the family from Arabidopsis localizes to chloroplasts or mitochondria.
[ "21" ]
Additional functions for members of the Whirly family were suggested by the fact that GFP fused to each member of the family from Arabidopsis localizes to chloroplasts or mitochondria.
true
true
true
true
true
7,176
2
INTRODUCTION
1
22
[ "B17", "B18", "B17", "B19", "B20", "B21", "B22", "B23" ]
18,676,978
pmid-14960277|pmid-10948264|pmid-14960277|pmid-12080340|pmid-17217467|pmid-15967440|pmid-16326926|pmid-18423020|pmid-11565746|NA|pmid-15891117|pmid-15010617|pmid-15197595|pmid-12678554
The copurification of AtWHY1 with a transcriptionally active chloroplast DNA complex (22) and the association of AtWHY2 with mitochondrial nucleoids (23) confirmed that these proteins have organellar functions, but the nature of these functions is not known.
[ "17", "18", "17", "19", "20", "21", "22", "23" ]
258
41,610
1
false
The copurification of AtWHY1 with a transcriptionally active chloroplast DNA complex and the association of AtWHY2 with mitochondrial nucleoids confirmed that these proteins have organellar functions, but the nature of these functions is not known.
[ "22", "23" ]
The copurification of AtWHY1 with a transcriptionally active chloroplast DNA complex and the association of AtWHY2 with mitochondrial nucleoids confirmed that these proteins have organellar functions, but the nature of these functions is not known.
true
true
true
true
true
7,176
2
INTRODUCTION
1
17
[ "B17", "B18", "B17", "B19", "B20", "B21", "B22", "B23" ]
18,676,978
pmid-14960277|pmid-10948264|pmid-14960277|pmid-12080340|pmid-17217467|pmid-15967440|pmid-16326926|pmid-18423020|pmid-11565746|NA|pmid-15891117|pmid-15010617|pmid-15197595|pmid-12678554
Results presented here show that ZmWHY1 plays an essential role in the biogenesis of chloroplasts, that it is associated with DNA from throughout the chloroplast genome and that it interacts in vivo with a subset of chloroplast RNAs that includes the atpF intron.
[ "17", "18", "17", "19", "20", "21", "22", "23" ]
263
41,611
0
false
Results presented here show that ZmWHY1 plays an essential role in the biogenesis of chloroplasts, that it is associated with DNA from throughout the chloroplast genome and that it interacts in vivo with a subset of chloroplast RNAs that includes the atpF intron.
[]
Results presented here show that ZmWHY1 plays an essential role in the biogenesis of chloroplasts, that it is associated with DNA from throughout the chloroplast genome and that it interacts in vivo with a subset of chloroplast RNAs that includes the atpF intron.
true
true
true
true
true
7,176
2
INTRODUCTION
1
17
[ "B17", "B18", "B17", "B19", "B20", "B21", "B22", "B23" ]
18,676,978
pmid-14960277|pmid-10948264|pmid-14960277|pmid-12080340|pmid-17217467|pmid-15967440|pmid-16326926|pmid-18423020|pmid-11565746|NA|pmid-15891117|pmid-15010617|pmid-15197595|pmid-12678554
ZmWHY1 enhances atpF intron splicing and influences the biogenesis of the large ribosomal subunit.
[ "17", "18", "17", "19", "20", "21", "22", "23" ]
98
41,612
0
false
ZmWHY1 enhances atpF intron splicing and influences the biogenesis of the large ribosomal subunit.
[]
ZmWHY1 enhances atpF intron splicing and influences the biogenesis of the large ribosomal subunit.
true
true
true
true
true
7,176
2
INTRODUCTION
1
17
[ "B17", "B18", "B17", "B19", "B20", "B21", "B22", "B23" ]
18,676,978
pmid-14960277|pmid-10948264|pmid-14960277|pmid-12080340|pmid-17217467|pmid-15967440|pmid-16326926|pmid-18423020|pmid-11565746|NA|pmid-15891117|pmid-15010617|pmid-15197595|pmid-12678554
However, chloroplast DNA and RNAs in ZmWhy1 mutants accumulate to levels similar to those in other mutants with plastid ribosome deficiencies of similar magnitude.
[ "17", "18", "17", "19", "20", "21", "22", "23" ]
163
41,613
0
false
However, chloroplast DNA and RNAs in ZmWhy1 mutants accumulate to levels similar to those in other mutants with plastid ribosome deficiencies of similar magnitude.
[]
However, chloroplast DNA and RNAs in ZmWhy1 mutants accumulate to levels similar to those in other mutants with plastid ribosome deficiencies of similar magnitude.
true
true
true
true
true
7,176
2
INTRODUCTION
1
17
[ "B17", "B18", "B17", "B19", "B20", "B21", "B22", "B23" ]
18,676,978
pmid-14960277|pmid-10948264|pmid-14960277|pmid-12080340|pmid-17217467|pmid-15967440|pmid-16326926|pmid-18423020|pmid-11565746|NA|pmid-15891117|pmid-15010617|pmid-15197595|pmid-12678554
These results argue that ZmWHY1 is required neither for chloroplast DNA replication nor directly for global chloroplast transcription.
[ "17", "18", "17", "19", "20", "21", "22", "23" ]
134
41,614
0
false
These results argue that ZmWHY1 is required neither for chloroplast DNA replication nor directly for global chloroplast transcription.
[]
These results argue that ZmWHY1 is required neither for chloroplast DNA replication nor directly for global chloroplast transcription.
true
true
true
true
true
7,176
0
DISCUSSION
1
17
[ "B17", "B19", "B20", "B22" ]
18,676,978
NA|pmid-15269332|pmid-17105995|pmid-12955455|pmid-17295027|pmid-14960277|pmid-12080340|pmid-17217467|pmid-16326926
Previous reports have attributed diverse functions and intracellular locations to WHY1.
[ "17", "19", "20", "22" ]
87
41,615
0
false
Previous reports have attributed diverse functions and intracellular locations to WHY1.
[]
Previous reports have attributed diverse functions and intracellular locations to WHY1.
true
true
true
true
true
7,177
0
DISCUSSION
1
20
[ "B17", "B19", "B20", "B22" ]
18,676,978
NA|pmid-15269332|pmid-17105995|pmid-12955455|pmid-17295027|pmid-14960277|pmid-12080340|pmid-17217467|pmid-16326926
WHY1 in dicots has been reported to be a ssDNA-binding protein that functions in the nucleus as both a transcription factor (17,19) and as a negative regulator of telomere length (20).
[ "17", "19", "20", "22" ]
184
41,616
1
false
WHY1 in dicots has been reported to be a ssDNA-binding protein that functions in the nucleus as both a transcription factor and as a negative regulator of telomere length.
[ "17,19", "20" ]
WHY1 in dicots has been reported to be a ssDNA-binding protein that functions in the nucleus as both a transcription factor and as a negative regulator of telomere length.
true
true
true
true
true
7,177
0
DISCUSSION
1
22
[ "B17", "B19", "B20", "B22" ]
18,676,978
NA|pmid-15269332|pmid-17105995|pmid-12955455|pmid-17295027|pmid-14960277|pmid-12080340|pmid-17217467|pmid-16326926
Arabidopsis WHY1 copurified with the ‘transcriptionally active chromosome’ from chloroplasts (22).
[ "17", "19", "20", "22" ]
98
41,617
1
false
Arabidopsis WHY1 copurified with the ‘transcriptionally active chromosome’ from chloroplasts.
[ "22" ]
Arabidopsis WHY1 copurified with the ‘transcriptionally active chromosome’ from chloroplasts.
true
true
true
true
true
7,177
0
DISCUSSION
1
17
[ "B17", "B19", "B20", "B22" ]
18,676,978
NA|pmid-15269332|pmid-17105995|pmid-12955455|pmid-17295027|pmid-14960277|pmid-12080340|pmid-17217467|pmid-16326926
Our results add another layer to this complex picture.
[ "17", "19", "20", "22" ]
54
41,618
0
false
Our results add another layer to this complex picture.
[]
Our results add another layer to this complex picture.
true
true
true
true
true
7,177