Split (1)

train · 816k rows

paragraph_index int64	sec string	p_has_citation int64	cites string	citeids list	pmid int64	cited_id string	sentences string	all_sent_cites list	sent_len int64	sentence_batch_index int64	sent_has_citation float64	qc_fail bool	cited_sentence string	cites_in_sentence list	cln_sentence string	is_cap bool	is_alpha bool	ends_wp bool	cit_qc bool	lgtm bool	__index_level_0__ int64
1	DISCUSSION	1	10	[ "B10", "B12", "B22", "B23", "B24", "B25", "B11" ]	15,716,603	pmid-7525417\|pmid-9679948\|pmid-9102204\|pmid-9744541\|pmid-7574932\|pmid-3395818\|pmid-9395230\|pmid-10910963\|pmid-14684572\|pmid-8804119\|pmid-9679948\|pmid-9744541\|pmid-7525094\|pmid-8640931\|pmid-11606502\|pmid-11731407\|pmid-9102204	Therefore, it may be useful in clarifying the biological role of iNOS expression on Barrett's esophagus-associated adenocarcinoma to study the effect of iNOS inhibitor on animal esophageal adenocarcinoma model.	[ "10", "12", "22", "23", "24", "25", "11" ]	210	42,619	0	false	Therefore, it may be useful in clarifying the biological role of iNOS expression on Barrett's esophagus-associated adenocarcinoma to study the effect of iNOS inhibitor on animal esophageal adenocarcinoma model.	[]	Therefore, it may be useful in clarifying the biological role of iNOS expression on Barrett's esophagus-associated adenocarcinoma to study the effect of iNOS inhibitor on animal esophageal adenocarcinoma model.	true	true	true	true	true	7,386
2	DISCUSSION	1	18	[ "B18", "B26", "B27", "B28", "B29", "B10", "B12", "B11" ]	15,716,603	pmid-14684572\|pmid-14648704\|pmid-7688473\|pmid-7514189\|pmid-11910360\|pmid-9679948\|pmid-9744541\|pmid-9102204	We have observed over-expression of COX-2, microsomal prostaglandin synthase-1 and EP receptors in this model (18).	[ "18", "26", "27", "28", "29", "10", "12", "11" ]	115	42,620	1	false	We have observed over-expression of COX-2, microsomal prostaglandin synthase-1 and EP receptors in this model.	[ "18" ]	We have observed over-expression of COX-2, microsomal prostaglandin synthase-1 and EP receptors in this model.	true	true	true	true	true	7,387
2	DISCUSSION	1	26	[ "B18", "B26", "B27", "B28", "B29", "B10", "B12", "B11" ]	15,716,603	pmid-14684572\|pmid-14648704\|pmid-7688473\|pmid-7514189\|pmid-11910360\|pmid-9679948\|pmid-9744541\|pmid-9102204	Recently, PGE2 mediates up-regulation of iNOS in murine breast cancer cell line through EP4 receptors activation (26).	[ "18", "26", "27", "28", "29", "10", "12", "11" ]	118	42,621	1	false	Recently, PGE2 mediates up-regulation of iNOS in murine breast cancer cell line through EP4 receptors activation.	[ "26" ]	Recently, PGE2 mediates up-regulation of iNOS in murine breast cancer cell line through EP4 receptors activation.	true	true	true	true	true	7,387
2	DISCUSSION	1	18	[ "B18", "B26", "B27", "B28", "B29", "B10", "B12", "B11" ]	15,716,603	pmid-14684572\|pmid-14648704\|pmid-7688473\|pmid-7514189\|pmid-11910360\|pmid-9679948\|pmid-9744541\|pmid-9102204	NO has been also found to enhance the activity and expression of COX-2 (27, 28).	[ "18", "26", "27", "28", "29", "10", "12", "11" ]	80	42,622	0	false	NO has been also found to enhance the activity and expression of COX-2.	[ "27, 28" ]	NO has been also found to enhance the activity and expression of COX-2.	true	true	true	true	true	7,387
2	DISCUSSION	1	29	[ "B18", "B26", "B27", "B28", "B29", "B10", "B12", "B11" ]	15,716,603	pmid-14684572\|pmid-14648704\|pmid-7688473\|pmid-7514189\|pmid-11910360\|pmid-9679948\|pmid-9744541\|pmid-9102204	Use of COX-2 inhibitors resulted in a reduction of the development of esophageal adenocarcinoma induced by duodenal reflux (29).	[ "18", "26", "27", "28", "29", "10", "12", "11" ]	128	42,623	1	false	Use of COX-2 inhibitors resulted in a reduction of the development of esophageal adenocarcinoma induced by duodenal reflux.	[ "29" ]	Use of COX-2 inhibitors resulted in a reduction of the development of esophageal adenocarcinoma induced by duodenal reflux.	true	true	true	true	true	7,387
2	DISCUSSION	1	18	[ "B18", "B26", "B27", "B28", "B29", "B10", "B12", "B11" ]	15,716,603	pmid-14684572\|pmid-14648704\|pmid-7688473\|pmid-7514189\|pmid-11910360\|pmid-9679948\|pmid-9744541\|pmid-9102204	These findings suggest that cross talk between NO and COX pathway may play an important role in Barrett's esophagus-associated neoplastic progression.	[ "18", "26", "27", "28", "29", "10", "12", "11" ]	150	42,624	0	false	These findings suggest that cross talk between NO and COX pathway may play an important role in Barrett's esophagus-associated neoplastic progression.	[]	These findings suggest that cross talk between NO and COX pathway may play an important role in Barrett's esophagus-associated neoplastic progression.	true	true	true	true	true	7,387
2	DISCUSSION	1	18	[ "B18", "B26", "B27", "B28", "B29", "B10", "B12", "B11" ]	15,716,603	pmid-14684572\|pmid-14648704\|pmid-7688473\|pmid-7514189\|pmid-11910360\|pmid-9679948\|pmid-9744541\|pmid-9102204	In Barrett's esophagus, iNOS expression was observed at the cytoplasmic area of stromal and epithelial cells (10, 12).	[ "18", "26", "27", "28", "29", "10", "12", "11" ]	118	42,625	0	false	In Barrett's esophagus, iNOS expression was observed at the cytoplasmic area of stromal and epithelial cells.	[ "10, 12" ]	In Barrett's esophagus, iNOS expression was observed at the cytoplasmic area of stromal and epithelial cells.	true	true	true	true	true	7,387
2	DISCUSSION	1	18	[ "B18", "B26", "B27", "B28", "B29", "B10", "B12", "B11" ]	15,716,603	pmid-14684572\|pmid-14648704\|pmid-7688473\|pmid-7514189\|pmid-11910360\|pmid-9679948\|pmid-9744541\|pmid-9102204	In contrast, our study revealed characteristic localization at the apical surface of epithelial cells.	[ "18", "26", "27", "28", "29", "10", "12", "11" ]	102	42,626	0	false	In contrast, our study revealed characteristic localization at the apical surface of epithelial cells.	[]	In contrast, our study revealed characteristic localization at the apical surface of epithelial cells.	true	true	true	true	true	7,387
2	DISCUSSION	1	11	[ "B18", "B26", "B27", "B28", "B29", "B10", "B12", "B11" ]	15,716,603	pmid-14684572\|pmid-14648704\|pmid-7688473\|pmid-7514189\|pmid-11910360\|pmid-9679948\|pmid-9744541\|pmid-9102204	This result is in agreement with immunolocalization of iNOS in rat colon tumors induced by azoxymethane (11).	[ "18", "26", "27", "28", "29", "10", "12", "11" ]	109	42,627	1	false	This result is in agreement with immunolocalization of iNOS in rat colon tumors induced by azoxymethane.	[ "11" ]	This result is in agreement with immunolocalization of iNOS in rat colon tumors induced by azoxymethane.	true	true	true	true	true	7,387
2	DISCUSSION	1	18	[ "B18", "B26", "B27", "B28", "B29", "B10", "B12", "B11" ]	15,716,603	pmid-14684572\|pmid-14648704\|pmid-7688473\|pmid-7514189\|pmid-11910360\|pmid-9679948\|pmid-9744541\|pmid-9102204	Its significance remains to be determined.	[ "18", "26", "27", "28", "29", "10", "12", "11" ]	42	42,628	0	false	Its significance remains to be determined.	[]	Its significance remains to be determined.	true	true	true	true	true	7,387
0	INTRODUCTION	1	1	[ "B1", "B1" ]	20,733,961	pmid-9598491\|pmid-9598491\|pmid-16939474\|pmid-7816861\|pmid-2357567	Selective serotonin reuptake inhibitors (SSRIs) have previously been used as a treatment for premature ejaculation.	[ "1", "1" ]	115	42,629	0	false	Selective serotonin reuptake inhibitors (SSRIs) have previously been used as a treatment for premature ejaculation.	[]	Selective serotonin reuptake inhibitors (SSRIs) have previously been used as a treatment for premature ejaculation.	true	true	true	true	true	7,388
0	INTRODUCTION	1	1	[ "B1", "B1" ]	20,733,961	pmid-9598491\|pmid-9598491\|pmid-16939474\|pmid-7816861\|pmid-2357567	The use of SSRIs for the treatment of premature ejaculation began after it was discovered that treatment of depression in males with SSRIs resulted in a side effect of delayed ejaculation [1].	[ "1", "1" ]	192	42,630	1	false	The use of SSRIs for the treatment of premature ejaculation began after it was discovered that treatment of depression in males with SSRIs resulted in a side effect of delayed ejaculation.	[ "1" ]	The use of SSRIs for the treatment of premature ejaculation began after it was discovered that treatment of depression in males with SSRIs resulted in a side effect of delayed ejaculation.	true	true	true	true	true	7,388
0	INTRODUCTION	1	1	[ "B1", "B1" ]	20,733,961	pmid-9598491\|pmid-9598491\|pmid-16939474\|pmid-7816861\|pmid-2357567	Sertraline is an SSRI, and its treatment efficacy for premature ejaculation has also been reported	[ "1", "1" ]	98	42,631	0	false	Sertraline is an SSRI, and its treatment efficacy for premature ejaculation has also been reported	[]	Sertraline is an SSRI, and its treatment efficacy for premature ejaculation has also been reported	true	true	false	true	false	7,388
1	INTRODUCTION	1	2	[ "B2" ]	20,733,961	pmid-7876038\|pmid-18194183	Current-source analysis of electroencephalography (EEG) is an electrographic and functional imaging method that is used to find the current source of neuronal activity of the brain.	[ "2" ]	181	42,632	0	false	Current-source analysis of electroencephalography (EEG) is an electrographic and functional imaging method that is used to find the current source of neuronal activity of the brain.	[]	Current-source analysis of electroencephalography (EEG) is an electrographic and functional imaging method that is used to find the current source of neuronal activity of the brain.	true	true	true	true	true	7,389
1	INTRODUCTION	1	2	[ "B2" ]	20,733,961	pmid-7876038\|pmid-18194183	It involves a computational and mathematical algorithm that analyzes digital EEG data.	[ "2" ]	86	42,633	0	false	It involves a computational and mathematical algorithm that analyzes digital EEG data.	[]	It involves a computational and mathematical algorithm that analyzes digital EEG data.	true	true	true	true	true	7,389
1	INTRODUCTION	1	2	[ "B2" ]	20,733,961	pmid-7876038\|pmid-18194183	The discrete model of current-source analysis provides information about location, strength, and orientation of current-source dipoles.	[ "2" ]	135	42,634	0	false	The discrete model of current-source analysis provides information about location, strength, and orientation of current-source dipoles.	[]	The discrete model of current-source analysis provides information about location, strength, and orientation of current-source dipoles.	true	true	true	true	true	7,389
1	INTRODUCTION	1	2	[ "B2" ]	20,733,961	pmid-7876038\|pmid-18194183	The distributed model is a method used to find the location and extent of the current source distribution.	[ "2" ]	106	42,635	0	false	The distributed model is a method used to find the location and extent of the current source distribution.	[]	The distributed model is a method used to find the location and extent of the current source distribution.	true	true	true	true	true	7,389
1	INTRODUCTION	1	2	[ "B2" ]	20,733,961	pmid-7876038\|pmid-18194183	Low-resolution electromagnetic tomography (LORETA) is a distributed model of current-source analysis [2].	[ "2" ]	105	42,636	1	false	Low-resolution electromagnetic tomography (LORETA) is a distributed model of current-source analysis.	[ "2" ]	Low-resolution electromagnetic tomography (LORETA) is a distributed model of current-source analysis.	true	true	true	true	true	7,389
2	INTRODUCTION	1	3	[ "B3", "B4", "B5" ]	20,733,961	pmid-20331719\|pmid-8753932\|pmid-7577330\|NA	Studies of neurocognitive function using EEG data have focused on the frequency band above 20 Hz.	[ "3", "4", "5" ]	97	42,637	0	false	Studies of neurocognitive function using EEG data have focused on the frequency band above 20 Hz.	[]	Studies of neurocognitive function using EEG data have focused on the frequency band above 20 Hz.	true	true	true	true	true	7,390
2	INTRODUCTION	1	3	[ "B3", "B4", "B5" ]	20,733,961	pmid-20331719\|pmid-8753932\|pmid-7577330\|NA	It has been shown in human EEG studies that cortical high-frequency activity is topically enhanced in various cognitive processes [3].	[ "3", "4", "5" ]	134	42,638	1	false	It has been shown in human EEG studies that cortical high-frequency activity is topically enhanced in various cognitive processes.	[ "3" ]	It has been shown in human EEG studies that cortical high-frequency activity is topically enhanced in various cognitive processes.	true	true	true	true	true	7,390
2	INTRODUCTION	1	3	[ "B3", "B4", "B5" ]	20,733,961	pmid-20331719\|pmid-8753932\|pmid-7577330\|NA	Complex cognitive tasks ignite neuronal cell assemblies and activate loops of neuronal networks.	[ "3", "4", "5" ]	96	42,639	0	false	Complex cognitive tasks ignite neuronal cell assemblies and activate loops of neuronal networks.	[]	Complex cognitive tasks ignite neuronal cell assemblies and activate loops of neuronal networks.	true	true	true	true	true	7,390
2	INTRODUCTION	1	4	[ "B3", "B4", "B5" ]	20,733,961	pmid-20331719\|pmid-8753932\|pmid-7577330\|NA	In the case of language processing, a loop between Broca's and Wernicke's regions is activated [4].	[ "3", "4", "5" ]	99	42,640	1	false	In the case of language processing, a loop between Broca's and Wernicke's regions is activated.	[ "4" ]	In the case of language processing, a loop between Broca's and Wernicke's regions is activated.	true	true	true	true	true	7,390
2	INTRODUCTION	1	3	[ "B3", "B4", "B5" ]	20,733,961	pmid-20331719\|pmid-8753932\|pmid-7577330\|NA	The neuronal oscillations have a circulation frequency of 25 to 30 Hz.	[ "3", "4", "5" ]	70	42,641	0	false	The neuronal oscillations have a circulation frequency of 25 to 30 Hz.	[]	The neuronal oscillations have a circulation frequency of 25 to 30 Hz.	true	true	true	true	true	7,390
2	INTRODUCTION	1	5	[ "B3", "B4", "B5" ]	20,733,961	pmid-20331719\|pmid-8753932\|pmid-7577330\|NA	In contrast, higher-frequency oscillatory cortical activity, in the range of 40 to 60 Hz, is observed in less widely dispersed cell assemblies [5].	[ "3", "4", "5" ]	147	42,642	1	false	In contrast, higher-frequency oscillatory cortical activity, in the range of 40 to 60 Hz, is observed in less widely dispersed cell assemblies.	[ "5" ]	In contrast, higher-frequency oscillatory cortical activity, in the range of 40 to 60 Hz, is observed in less widely dispersed cell assemblies.	true	true	true	true	true	7,390
2	INTRODUCTION	1	3	[ "B3", "B4", "B5" ]	20,733,961	pmid-20331719\|pmid-8753932\|pmid-7577330\|NA	The highest frequency band that can be analyzed by LORETA is the high beta frequency band (22-30 Hz).	[ "3", "4", "5" ]	101	42,643	0	false	The highest frequency band that can be analyzed by LORETA is the high beta frequency band.	[ "22-30 Hz" ]	The highest frequency band that can be analyzed by LORETA is the high beta frequency band.	true	true	true	true	true	7,390
2	INTRODUCTION	1	3	[ "B3", "B4", "B5" ]	20,733,961	pmid-20331719\|pmid-8753932\|pmid-7577330\|NA	The analysis of this frequency band may be helpful for evaluating neurocognitive functions in various situations.	[ "3", "4", "5" ]	113	42,644	0	false	The analysis of this frequency band may be helpful for evaluating neurocognitive functions in various situations.	[]	The analysis of this frequency band may be helpful for evaluating neurocognitive functions in various situations.	true	true	true	true	true	7,390
3	INTRODUCTION	1	6	[ "B6" ]	20,733,961	pmid-18194183	Little is known about the cerebral control mechanisms of ejaculation.	[ "6" ]	69	42,645	0	false	Little is known about the cerebral control mechanisms of ejaculation.	[]	Little is known about the cerebral control mechanisms of ejaculation.	true	true	true	true	true	7,391
3	INTRODUCTION	1	6	[ "B6" ]	20,733,961	pmid-18194183	According to our previous study using EEG recordings from patients with premature ejaculation (PE) [6], we observed decreased neuronal activity in the precentral gyrus and the insula of the right cerebral hemisphere and in both superior parietal lobules during sexual arousal induced by erotic videos.	[ "6" ]	301	42,646	1	false	According to our previous study using EEG recordings from patients with premature ejaculation (PE), we observed decreased neuronal activity in the precentral gyrus and the insula of the right cerebral hemisphere and in both superior parietal lobules during sexual arousal induced by erotic videos.	[ "6" ]	According to our previous study using EEG recordings from patients with premature ejaculation (PE), we observed decreased neuronal activity in the precentral gyrus and the insula of the right cerebral hemisphere and in both superior parietal lobules during sexual arousal induced by erotic videos.	true	true	true	true	true	7,391
3	INTRODUCTION	1	6	[ "B6" ]	20,733,961	pmid-18194183	In addition, the neuronal activity of PE patients decreased in the right parahippocampal gyrus and in the left middle temporal gyrus compared with normal controls.	[ "6" ]	163	42,647	0	false	In addition, the neuronal activity of PE patients decreased in the right parahippocampal gyrus and in the left middle temporal gyrus compared with normal controls.	[]	In addition, the neuronal activity of PE patients decreased in the right parahippocampal gyrus and in the left middle temporal gyrus compared with normal controls.	true	true	true	true	true	7,391
3	INTRODUCTION	1	6	[ "B6" ]	20,733,961	pmid-18194183	These findings suggest that the inhibitory control of ejaculation in the central nervous system may be impaired in PE patients.	[ "6" ]	127	42,648	0	false	These findings suggest that the inhibitory control of ejaculation in the central nervous system may be impaired in PE patients.	[]	These findings suggest that the inhibitory control of ejaculation in the central nervous system may be impaired in PE patients.	true	true	true	true	true	7,391
3	INTRODUCTION	1	6	[ "B6" ]	20,733,961	pmid-18194183	The purpose of this study was to examine the changes in the brain current-source density of the high beta frequency band (22-30 Hz) induced by sertraline administration and erotic stimuli in healthy adult males.	[ "6" ]	211	42,649	0	false	The purpose of this study was to examine the changes in the brain current-source density of the high beta frequency band (22-30 Hz) induced by sertraline administration and erotic stimuli in healthy adult males.	[]	The purpose of this study was to examine the changes in the brain current-source density of the high beta frequency band (22-30 Hz) induced by sertraline administration and erotic stimuli in healthy adult males.	true	true	true	true	true	7,391
0	DISCUSSION	1	12	[ "B12", "B14", "B13" ]	20,733,961	pmid-9598491\|pmid-9598491\|pmid-16939474\|pmid-7816861\|pmid-2357567	It is known that the serotonin pathway plays a role in the mechanism of ejaculation in males.	[ "12", "14", "13" ]	93	42,650	0	false	It is known that the serotonin pathway plays a role in the mechanism of ejaculation in males.	[]	It is known that the serotonin pathway plays a role in the mechanism of ejaculation in males.	true	true	true	true	true	7,392
0	DISCUSSION	1	12	[ "B12", "B14", "B13" ]	20,733,961	pmid-9598491\|pmid-9598491\|pmid-16939474\|pmid-7816861\|pmid-2357567	In the central nervous system, the medial preoptic area, nucleus paragigantocellularis, stria terminalis, amygdala, and thalamus may be the anatomical locations associated with this mechanism [12-14].	[ "12", "14", "13" ]	200	42,651	0	false	In the central nervous system, the medial preoptic area, nucleus paragigantocellularis, stria terminalis, amygdala, and thalamus may be the anatomical locations associated with this mechanism.	[ "12-14" ]	In the central nervous system, the medial preoptic area, nucleus paragigantocellularis, stria terminalis, amygdala, and thalamus may be the anatomical locations associated with this mechanism.	true	true	true	true	true	7,392
0	DISCUSSION	1	12	[ "B12", "B14", "B13" ]	20,733,961	pmid-9598491\|pmid-9598491\|pmid-16939474\|pmid-7816861\|pmid-2357567	Serotonergic pathways descending from the nucleus paragigantocellularis to the lumbosacral motor nuclei tonically inhibit ejaculation.	[ "12", "14", "13" ]	134	42,652	0	false	Serotonergic pathways descending from the nucleus paragigantocellularis to the lumbosacral motor nuclei tonically inhibit ejaculation.	[]	Serotonergic pathways descending from the nucleus paragigantocellularis to the lumbosacral motor nuclei tonically inhibit ejaculation.	true	true	true	true	true	7,392
0	DISCUSSION	1	13	[ "B12", "B14", "B13" ]	20,733,961	pmid-9598491\|pmid-9598491\|pmid-16939474\|pmid-7816861\|pmid-2357567	When the signal from the medial preoptic area inhibits the nucleus paragigantocellularis, the motor nuclei in the lumbosacral spinal area are released from the tonic inhibition of the nucleus paragigantocellularis, which allows ejaculation [13].	[ "12", "14", "13" ]	245	42,653	1	false	When the signal from the medial preoptic area inhibits the nucleus paragigantocellularis, the motor nuclei in the lumbosacral spinal area are released from the tonic inhibition of the nucleus paragigantocellularis, which allows ejaculation.	[ "13" ]	When the signal from the medial preoptic area inhibits the nucleus paragigantocellularis, the motor nuclei in the lumbosacral spinal area are released from the tonic inhibition of the nucleus paragigantocellularis, which allows ejaculation.	true	true	true	true	true	7,392
1	DISCUSSION	1	6	[ "B6" ]	20,733,961	pmid-7876038\|pmid-18194183	In our previous study, we found that the neuronal activity of PE patients decreased in the precentral gyrus and the insula of the right cerebral hemisphere and in both of the superior parietal lobules during sexual arousal induced by erotic videos [6].	[ "6" ]	252	42,654	1	false	In our previous study, we found that the neuronal activity of PE patients decreased in the precentral gyrus and the insula of the right cerebral hemisphere and in both of the superior parietal lobules during sexual arousal induced by erotic videos.	[ "6" ]	In our previous study, we found that the neuronal activity of PE patients decreased in the precentral gyrus and the insula of the right cerebral hemisphere and in both of the superior parietal lobules during sexual arousal induced by erotic videos.	true	true	true	true	true	7,393
1	DISCUSSION	1	6	[ "B6" ]	20,733,961	pmid-7876038\|pmid-18194183	In addition, the activity decreased in the right parahippocampal gyrus and in the left middle temporal gyrus compared with the normal controls.	[ "6" ]	143	42,655	0	false	In addition, the activity decreased in the right parahippocampal gyrus and in the left middle temporal gyrus compared with the normal controls.	[]	In addition, the activity decreased in the right parahippocampal gyrus and in the left middle temporal gyrus compared with the normal controls.	true	true	true	true	true	7,393
1	DISCUSSION	1	6	[ "B6" ]	20,733,961	pmid-7876038\|pmid-18194183	These results suggested that the debasement of inhibitory control in the central nervous system located above the medial preoptic area may be a cause of premature ejaculation.	[ "6" ]	175	42,656	0	false	These results suggested that the debasement of inhibitory control in the central nervous system located above the medial preoptic area may be a cause of premature ejaculation.	[]	These results suggested that the debasement of inhibitory control in the central nervous system located above the medial preoptic area may be a cause of premature ejaculation.	true	true	true	true	true	7,393
2	DISCUSSION	1	15	[ "B15" ]	20,733,961	pmid-20331719\|pmid-8753932\|pmid-7577330\|NA	When SSRIs are administered to patients for the treatment of depression, the brain activity measured by functional magnetic resonance imaging (fMRI) decreases in the cingulate gyrus and the caudate nucleus	[ "15" ]	205	42,657	0	false	When SSRIs are administered to patients for the treatment of depression, the brain activity measured by functional magnetic resonance imaging (fMRI) decreases in the cingulate gyrus and the caudate nucleus	[]	When SSRIs are administered to patients for the treatment of depression, the brain activity measured by functional magnetic resonance imaging (fMRI) decreases in the cingulate gyrus and the caudate nucleus	true	true	false	true	false	7,394
2	DISCUSSION	1	15	[ "B15" ]	20,733,961	pmid-20331719\|pmid-8753932\|pmid-7577330\|NA	Positron emission tomography (PET) and fMRI are methods used to evaluate neural activity indirectly by observing local cerebral blood flow or metabolism without observing neuronal activity directly.	[ "15" ]	198	42,658	0	false	Positron emission tomography (PET) and fMRI are methods used to evaluate neural activity indirectly by observing local cerebral blood flow or metabolism without observing neuronal activity directly.	[]	Positron emission tomography (PET) and fMRI are methods used to evaluate neural activity indirectly by observing local cerebral blood flow or metabolism without observing neuronal activity directly.	true	true	true	true	true	7,394
2	DISCUSSION	1	15	[ "B15" ]	20,733,961	pmid-20331719\|pmid-8753932\|pmid-7577330\|NA	In contrast, the current-source analysis of EEGs observes the electric activity of neurons directly.	[ "15" ]	100	42,659	0	false	In contrast, the current-source analysis of EEGs observes the electric activity of neurons directly.	[]	In contrast, the current-source analysis of EEGs observes the electric activity of neurons directly.	true	true	true	true	true	7,394
2	DISCUSSION	1	15	[ "B15" ]	20,733,961	pmid-20331719\|pmid-8753932\|pmid-7577330\|NA	Therefore, results from the current-source analysis of EEGs may differ from the results of studies using PET or fMRI.	[ "15" ]	117	42,660	0	false	Therefore, results from the current-source analysis of EEGs may differ from the results of studies using PET or fMRI.	[]	Therefore, results from the current-source analysis of EEGs may differ from the results of studies using PET or fMRI.	true	true	true	true	true	7,394
3	DISCUSSION	0	null	null	20,733,961	pmid-18194183	We recorded EEGs before and 4 hours after sertraline intake in healthy, right-handed young males under erotic stimulation using sexual video excerpts and analyzed the current source of the high beta frequency band by using a distributed model.	null	243	42,661	0	false	null	null	We recorded EEGs before and 4 hours after sertraline intake in healthy, right-handed young males under erotic stimulation using sexual video excerpts and analyzed the current source of the high beta frequency band by using a distributed model.	true	true	true	true	true	7,395
3	DISCUSSION	0	null	null	20,733,961	pmid-18194183	Erotic stimuli decreased the current source density of the high beta frequency band in the middle frontal gyrus, the precentral gyrus, the postcentral gyrus, and the supramarginal gyrus of the left cerebral hemisphere in the baseline EEGs (p<0.05) (Table 1, Fig.	null	262	42,662	0	false	null	null	Erotic stimuli decreased the current source density of the high beta frequency band in the middle frontal gyrus, the precentral gyrus, the postcentral gyrus, and the supramarginal gyrus of the left cerebral hemisphere in the baseline EEGs (p<0.05) (Table 1, Fig.	true	true	true	true	true	7,395
3	DISCUSSION	0	null	null	20,733,961	pmid-18194183	These changes were not observed 4 hours after sertraline was administered.	null	74	42,663	0	false	null	null	These changes were not observed 4 hours after sertraline was administered.	true	true	true	true	true	7,395
3	DISCUSSION	0	null	null	20,733,961	pmid-18194183	In addition, we also observed that sertraline increased the current-source density in the superior, middle, and inferior frontal gyri and the precentral gyrus of the left cerebral hemisphere (p<0.05) (Table 2, Fig 2).	null	217	42,664	0	false	null	null	In addition, we also observed that sertraline increased the current-source density in the superior, middle, and inferior frontal gyri and the precentral gyrus of the left cerebral hemisphere (p<0.05) (Table 2, Fig 2).	true	true	true	true	true	7,395
3	DISCUSSION	0	null	null	20,733,961	pmid-18194183	According to these results, the erotic stimuli may trigger a functional debasement of inhibitory controls in the middle frontal gyrus, the postcentral gyrus, the precentral gyrus, and the supramarginal gyrus of the left cerebral hemisphere, which may lead to the sexually excited state.	null	286	42,665	0	false	null	null	According to these results, the erotic stimuli may trigger a functional debasement of inhibitory controls in the middle frontal gyrus, the postcentral gyrus, the precentral gyrus, and the supramarginal gyrus of the left cerebral hemisphere, which may lead to the sexually excited state.	true	true	true	true	true	7,395
3	DISCUSSION	0	null	null	20,733,961	pmid-18194183	It is also possible that sertraline may suppress these cerebral changes and decrease sexual excitement.	null	103	42,666	0	false	null	null	It is also possible that sertraline may suppress these cerebral changes and decrease sexual excitement.	true	true	true	true	true	7,395
3	DISCUSSION	0	null	null	20,733,961	pmid-18194183	In addition, sertraline may reduce the excessive sexual excitement in the brain, prolong the duration of an erection, and suppress ejaculation.	null	143	42,667	0	false	null	null	In addition, sertraline may reduce the excessive sexual excitement in the brain, prolong the duration of an erection, and suppress ejaculation.	true	true	true	true	true	7,395
4	DISCUSSION	1	16	[ "B16", "B17", "B18", "B19" ]	20,733,961	pmid-19818382\|pmid-19407204\|pmid-17823419\|pmid-16399686	The prefrontal cortex is known to be a crucial area for cognitive control [16], and the dorsolateral prefrontal cortex (DLPFC) is involved in self-control	[ "16", "17", "18", "19" ]	154	42,668	1	false	The prefrontal cortex is known to be a crucial area for cognitive control, and the dorsolateral prefrontal cortex (DLPFC) is involved in self-control	[ "16" ]	The prefrontal cortex is known to be a crucial area for cognitive control, and the dorsolateral prefrontal cortex (DLPFC) is involved in self-control	true	true	false	true	false	7,396
4	DISCUSSION	1	18	[ "B16", "B17", "B18", "B19" ]	20,733,961	pmid-19818382\|pmid-19407204\|pmid-17823419\|pmid-16399686	In a study observing the reaction of the cerebral cortex to meals in right-handed females, the decreased activity of the left DLPFC was associated with poor control of appetite and resulting obesity [18].	[ "16", "17", "18", "19" ]	204	42,669	1	false	In a study observing the reaction of the cerebral cortex to meals in right-handed females, the decreased activity of the left DLPFC was associated with poor control of appetite and resulting obesity.	[ "18" ]	In a study observing the reaction of the cerebral cortex to meals in right-handed females, the decreased activity of the left DLPFC was associated with poor control of appetite and resulting obesity.	true	true	true	true	true	7,396
4	DISCUSSION	1	19	[ "B16", "B17", "B18", "B19" ]	20,733,961	pmid-19818382\|pmid-19407204\|pmid-17823419\|pmid-16399686	In another study investigating the association between the stop-signal task and response inhibition, the precentral gyrus of the left cerebral hemisphere was activated during response inhibition, and this activation was associated with the stop-signal reaction time [19].	[ "16", "17", "18", "19" ]	271	42,670	1	false	In another study investigating the association between the stop-signal task and response inhibition, the precentral gyrus of the left cerebral hemisphere was activated during response inhibition, and this activation was associated with the stop-signal reaction time.	[ "19" ]	In another study investigating the association between the stop-signal task and response inhibition, the precentral gyrus of the left cerebral hemisphere was activated during response inhibition, and this activation was associated with the stop-signal reaction time.	true	true	true	true	true	7,396
4	DISCUSSION	1	16	[ "B16", "B17", "B18", "B19" ]	20,733,961	pmid-19818382\|pmid-19407204\|pmid-17823419\|pmid-16399686	Our results are similar to these reports in showing that the activity of the middle frontal gyrus and the precentral gyrus of the left cerebral hemisphere decreased during sexual arousal in right-handed healthy young males.	[ "16", "17", "18", "19" ]	223	42,671	0	false	Our results are similar to these reports in showing that the activity of the middle frontal gyrus and the precentral gyrus of the left cerebral hemisphere decreased during sexual arousal in right-handed healthy young males.	[]	Our results are similar to these reports in showing that the activity of the middle frontal gyrus and the precentral gyrus of the left cerebral hemisphere decreased during sexual arousal in right-handed healthy young males.	true	true	true	true	true	7,396
4	DISCUSSION	1	16	[ "B16", "B17", "B18", "B19" ]	20,733,961	pmid-19818382\|pmid-19407204\|pmid-17823419\|pmid-16399686	These changes recovered after administration of sertraline.	[ "16", "17", "18", "19" ]	59	42,672	0	false	These changes recovered after administration of sertraline.	[]	These changes recovered after administration of sertraline.	true	true	true	true	true	7,396
4	DISCUSSION	1	16	[ "B16", "B17", "B18", "B19" ]	20,733,961	pmid-19818382\|pmid-19407204\|pmid-17823419\|pmid-16399686	Taken together, these findings suggest that the debasement of inhibitory control by erotic stimuli in the middle frontal gyrus and the precentral gyrus of the left cerebral hemisphere may lead healthy young males to be excited sexually.	[ "16", "17", "18", "19" ]	236	42,673	0	false	Taken together, these findings suggest that the debasement of inhibitory control by erotic stimuli in the middle frontal gyrus and the precentral gyrus of the left cerebral hemisphere may lead healthy young males to be excited sexually.	[]	Taken together, these findings suggest that the debasement of inhibitory control by erotic stimuli in the middle frontal gyrus and the precentral gyrus of the left cerebral hemisphere may lead healthy young males to be excited sexually.	true	true	true	true	true	7,396
4	DISCUSSION	1	16	[ "B16", "B17", "B18", "B19" ]	20,733,961	pmid-19818382\|pmid-19407204\|pmid-17823419\|pmid-16399686	These results also suggest that inhibitory control may be recovered by the effects of sertraline.	[ "16", "17", "18", "19" ]	97	42,674	0	false	These results also suggest that inhibitory control may be recovered by the effects of sertraline.	[]	These results also suggest that inhibitory control may be recovered by the effects of sertraline.	true	true	true	true	true	7,396
5	DISCUSSION	1	20	[ "B20", "B21" ]	20,733,961	pmid-9918735\|pmid-12382157	The supramarginal gyrus of the left cerebral hemisphere is responsible for the detection of changes in phonological units [20].	[ "20", "21" ]	127	42,675	1	false	The supramarginal gyrus of the left cerebral hemisphere is responsible for the detection of changes in phonological units.	[ "20" ]	The supramarginal gyrus of the left cerebral hemisphere is responsible for the detection of changes in phonological units.	true	true	true	true	true	7,397
5	DISCUSSION	1	21	[ "B20", "B21" ]	20,733,961	pmid-9918735\|pmid-12382157	The postcentral gyrus is a somatosensory area, and lesions in the left postcentral gyrus induce sensory changes in the contralateral face and body [21].	[ "20", "21" ]	152	42,676	1	false	The postcentral gyrus is a somatosensory area, and lesions in the left postcentral gyrus induce sensory changes in the contralateral face and body.	[ "21" ]	The postcentral gyrus is a somatosensory area, and lesions in the left postcentral gyrus induce sensory changes in the contralateral face and body.	true	true	true	true	true	7,397
5	DISCUSSION	1	20	[ "B20", "B21" ]	20,733,961	pmid-9918735\|pmid-12382157	Even though it is difficult to interpret the changes induced by erotic stimuli in those areas, the aforementioned structures may also be a part of the cerebral inhibitory center that controls sexual excitement in males.	[ "20", "21" ]	219	42,677	0	false	Even though it is difficult to interpret the changes induced by erotic stimuli in those areas, the aforementioned structures may also be a part of the cerebral inhibitory center that controls sexual excitement in males.	[]	Even though it is difficult to interpret the changes induced by erotic stimuli in those areas, the aforementioned structures may also be a part of the cerebral inhibitory center that controls sexual excitement in males.	true	true	true	true	true	7,397
6	DISCUSSION	1	22	[ "B22", "B22", "B24", "B25", "B26", "B27" ]	20,733,961	pmid-10348329\|pmid-10348329\|pmid-11738201\|pmid-15351361\|pmid-16253551\|pmid-17029950	We used the small number of 25 available channels, which could have resulted in some localization errors, particularly in the basal aspects of the brain [22].	[ "22", "22", "24", "25", "26", "27" ]	158	42,678	1	false	We used the small number of 25 available channels, which could have resulted in some localization errors, particularly in the basal aspects of the brain.	[ "22" ]	We used the small number of 25 available channels, which could have resulted in some localization errors, particularly in the basal aspects of the brain.	true	true	true	true	true	7,398
6	DISCUSSION	1	22	[ "B22", "B22", "B24", "B25", "B26", "B27" ]	20,733,961	pmid-10348329\|pmid-10348329\|pmid-11738201\|pmid-15351361\|pmid-16253551\|pmid-17029950	The errors associated with using a spherical model with the small number of electrodes range from 10 to 20mm [22-24].	[ "22", "22", "24", "25", "26", "27" ]	117	42,679	0	false	The errors associated with using a spherical model with the small number of electrodes range from 10 to 20mm.	[ "22-24" ]	The errors associated with using a spherical model with the small number of electrodes range from 10 to 20mm.	true	true	true	true	true	7,398
6	DISCUSSION	1	25	[ "B22", "B22", "B24", "B25", "B26", "B27" ]	20,733,961	pmid-10348329\|pmid-10348329\|pmid-11738201\|pmid-15351361\|pmid-16253551\|pmid-17029950	The localization accuracy for LORETA has been shown to increase using 25 to 89 electrodes and to plateau thereafter [25].	[ "22", "22", "24", "25", "26", "27" ]	121	42,680	1	false	The localization accuracy for LORETA has been shown to increase using 25 to 89 electrodes and to plateau thereafter.	[ "25" ]	The localization accuracy for LORETA has been shown to increase using 25 to 89 electrodes and to plateau thereafter.	true	true	true	true	true	7,398
6	DISCUSSION	1	22	[ "B22", "B22", "B24", "B25", "B26", "B27" ]	20,733,961	pmid-10348329\|pmid-10348329\|pmid-11738201\|pmid-15351361\|pmid-16253551\|pmid-17029950	However, to localize the areas of increased activity, the small number of electrodes may be sufficient for the SnPM method of LORETA [26,27].	[ "22", "22", "24", "25", "26", "27" ]	141	42,681	0	false	However, to localize the areas of increased activity, the small number of electrodes may be sufficient for the SnPM method of LORETA.	[ "26,27" ]	However, to localize the areas of increased activity, the small number of electrodes may be sufficient for the SnPM method of LORETA.	true	true	true	true	true	7,398
6	DISCUSSION	1	22	[ "B22", "B22", "B24", "B25", "B26", "B27" ]	20,733,961	pmid-10348329\|pmid-10348329\|pmid-11738201\|pmid-15351361\|pmid-16253551\|pmid-17029950	It has also been observed that current source estimation using LORETA in a three-shell head model is similar when using between 19 and 46 scalp electrodes when the electrodes are evenly distributed.	[ "22", "22", "24", "25", "26", "27" ]	198	42,682	0	false	It has also been observed that current source estimation using LORETA in a three-shell head model is similar when using between 19 and 46 scalp electrodes when the electrodes are evenly distributed.	[]	It has also been observed that current source estimation using LORETA in a three-shell head model is similar when using between 19 and 46 scalp electrodes when the electrodes are evenly distributed.	true	true	true	true	true	7,398
6	DISCUSSION	1	22	[ "B22", "B22", "B24", "B25", "B26", "B27" ]	20,733,961	pmid-10348329\|pmid-10348329\|pmid-11738201\|pmid-15351361\|pmid-16253551\|pmid-17029950	To investigate cognitive function, lobar-level information may provide useful information, which is not the case for the current-source analysis of epilepsy.	[ "22", "22", "24", "25", "26", "27" ]	157	42,683	0	false	To investigate cognitive function, lobar-level information may provide useful information, which is not the case for the current-source analysis of epilepsy.	[]	To investigate cognitive function, lobar-level information may provide useful information, which is not the case for the current-source analysis of epilepsy.	true	true	true	true	true	7,398
7	DISCUSSION	1	28	[ "B28" ]	20,733,961	pmid-16467858	The changes in cerebral activity in response to erotic stimuli may differ depending on subject age [28].	[ "28" ]	104	42,684	1	false	The changes in cerebral activity in response to erotic stimuli may differ depending on subject age.	[ "28" ]	The changes in cerebral activity in response to erotic stimuli may differ depending on subject age.	true	true	true	true	true	7,399
7	DISCUSSION	1	28	[ "B28" ]	20,733,961	pmid-16467858	If the subjects were older, the results of this study could be different.	[ "28" ]	73	42,685	0	false	If the subjects were older, the results of this study could be different.	[]	If the subjects were older, the results of this study could be different.	true	true	true	true	true	7,399
7	DISCUSSION	1	28	[ "B28" ]	20,733,961	pmid-16467858	The results and interpretation of this study may be limited to young males.	[ "28" ]	75	42,686	0	false	The results and interpretation of this study may be limited to young males.	[]	The results and interpretation of this study may be limited to young males.	true	true	true	true	true	7,399
7	DISCUSSION	1	28	[ "B28" ]	20,733,961	pmid-16467858	Another limitation of this study is that we did not assess the objective level of sexual excitement by using penile erection status or other measures.	[ "28" ]	150	42,687	0	false	Another limitation of this study is that we did not assess the objective level of sexual excitement by using penile erection status or other measures.	[]	Another limitation of this study is that we did not assess the objective level of sexual excitement by using penile erection status or other measures.	true	true	true	true	true	7,399
7	DISCUSSION	1	28	[ "B28" ]	20,733,961	pmid-16467858	We addressed this limitation by using a self-report questionnaire to evaluate the status of sexual excitement, and all subjects reported that they experienced penile erection with sexual excitement.	[ "28" ]	198	42,688	0	false	We addressed this limitation by using a self-report questionnaire to evaluate the status of sexual excitement, and all subjects reported that they experienced penile erection with sexual excitement.	[]	We addressed this limitation by using a self-report questionnaire to evaluate the status of sexual excitement, and all subjects reported that they experienced penile erection with sexual excitement.	true	true	true	true	true	7,399
7	DISCUSSION	1	28	[ "B28" ]	20,733,961	pmid-16467858	Even though the repetitive exposures to erotic video could reduce the sexual arousal, the results of this study may still be reliable.	[ "28" ]	134	42,689	0	false	Even though the repetitive exposures to erotic video could reduce the sexual arousal, the results of this study may still be reliable.	[]	Even though the repetitive exposures to erotic video could reduce the sexual arousal, the results of this study may still be reliable.	true	true	true	true	true	7,399
7	DISCUSSION	1	28	[ "B28" ]	20,733,961	pmid-16467858	Because the refractory period of young adults may be short, the re-exposure to the same erotic video after 4 hours may not reduce the sexual arousal that much.	[ "28" ]	159	42,690	0	false	Because the refractory period of young adults may be short, the re-exposure to the same erotic video after 4 hours may not reduce the sexual arousal that much.	[]	Because the refractory period of young adults may be short, the re-exposure to the same erotic video after 4 hours may not reduce the sexual arousal that much.	true	true	true	true	true	7,399
7	DISCUSSION	1	28	[ "B28" ]	20,733,961	pmid-16467858	In addition, all attendants also reported the penile erection with sexual arousal in the questionnaires taken after the 2nd EEG sessions.	[ "28" ]	137	42,691	0	false	In addition, all attendants also reported the penile erection with sexual arousal in the questionnaires taken after the 2nd EEG sessions.	[]	In addition, all attendants also reported the penile erection with sexual arousal in the questionnaires taken after the 2nd EEG sessions.	true	true	true	true	true	7,399
8	DISCUSSION	0	null	null	20,733,961	null	More advanced studies can be based on the results presented here.	null	65	42,692	0	false	null	null	More advanced studies can be based on the results presented here.	true	true	true	true	true	7,400
8	DISCUSSION	0	null	null	20,733,961	null	Similar research designs could be adapted for future studies including healthy people or patients with sexual dysfunction in a range of age groups.	null	147	42,693	0	false	null	null	Similar research designs could be adapted for future studies including healthy people or patients with sexual dysfunction in a range of age groups.	true	true	true	true	true	7,400
8	DISCUSSION	0	null	null	20,733,961	null	The reliability of information could also be improved in a variety of ways in future studies.	null	93	42,694	0	false	null	null	The reliability of information could also be improved in a variety of ways in future studies.	true	true	true	true	true	7,400
8	DISCUSSION	0	null	null	20,733,961	null	We could use more objective monitoring, by measuring, for example, penile tumescence, and could conduct placebo-controlled studies.	null	131	42,695	0	false	null	null	We could use more objective monitoring, by measuring, for example, penile tumescence, and could conduct placebo-controlled studies.	true	true	true	true	true	7,400
8	DISCUSSION	0	null	null	20,733,961	null	Such research designs may be useful for pharmacological studies of many other drugs for sexual dysfunction.	null	107	42,696	0	false	null	null	Such research designs may be useful for pharmacological studies of many other drugs for sexual dysfunction.	true	true	true	true	true	7,400
0	DISCUSSION	1	16	[ "r16", "r18", "r30", "r31", "r21", "r31", "r32", "r17", "r33", "r2", "r3", "r20", "r21", "r34", "r35", "r2", "r3", "r20", "r21" ]	18,443,205	pmid-10723801\|pmid-14597638\|pmid-17303919\|pmid-10195896\|pmid-11489937\|pmid-10195896\|pmid-10195897\|pmid-10823818\|pmid-9346485\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937\|pmid-15951441\|pmid-16505240\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937	IKKβ is a core component of the oligomeric IKK complex, which consists of two catalytic subunits, IKKα and IKKβ, and a regulatory subunit IKKγ, or NEMO (16,18,30,31).	[ "16", "18", "30", "31", "21", "31", "32", "17", "33", "2", "3", "20", "21", "34", "35", "2", "3", "20", "21" ]	166	42,697	0	false	IKKβ is a core component of the oligomeric IKK complex, which consists of two catalytic subunits, IKKα and IKKβ, and a regulatory subunit IKKγ, or NEMO.	[ "16,18,30,31" ]	IKKβ is a core component of the oligomeric IKK complex, which consists of two catalytic subunits, IKKα and IKKβ, and a regulatory subunit IKKγ, or NEMO.	true	true	true	true	true	7,401
0	DISCUSSION	1	21	[ "r16", "r18", "r30", "r31", "r21", "r31", "r32", "r17", "r33", "r2", "r3", "r20", "r21", "r34", "r35", "r2", "r3", "r20", "r21" ]	18,443,205	pmid-10723801\|pmid-14597638\|pmid-17303919\|pmid-10195896\|pmid-11489937\|pmid-10195896\|pmid-10195897\|pmid-10823818\|pmid-9346485\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937\|pmid-15951441\|pmid-16505240\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937	The two catalytic subunits share ∼50% amino acid sequence homology, whereas the regulatory subunit does not contain a recognizable catalytic domain (21).	[ "16", "18", "30", "31", "21", "31", "32", "17", "33", "2", "3", "20", "21", "34", "35", "2", "3", "20", "21" ]	153	42,698	1	false	The two catalytic subunits share ∼50% amino acid sequence homology, whereas the regulatory subunit does not contain a recognizable catalytic domain.	[ "21" ]	The two catalytic subunits share ∼50% amino acid sequence homology, whereas the regulatory subunit does not contain a recognizable catalytic domain.	true	true	true	true	true	7,401
0	DISCUSSION	1	16	[ "r16", "r18", "r30", "r31", "r21", "r31", "r32", "r17", "r33", "r2", "r3", "r20", "r21", "r34", "r35", "r2", "r3", "r20", "r21" ]	18,443,205	pmid-10723801\|pmid-14597638\|pmid-17303919\|pmid-10195896\|pmid-11489937\|pmid-10195896\|pmid-10195897\|pmid-10823818\|pmid-9346485\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937\|pmid-15951441\|pmid-16505240\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937	Despite the overall sequence identity between IKKα and IKKβ, these subunits have specialized roles as mediators of cellular stress.	[ "16", "18", "30", "31", "21", "31", "32", "17", "33", "2", "3", "20", "21", "34", "35", "2", "3", "20", "21" ]	131	42,699	0	false	Despite the overall sequence identity between IKKα and IKKβ, these subunits have specialized roles as mediators of cellular stress.	[]	Despite the overall sequence identity between IKKα and IKKβ, these subunits have specialized roles as mediators of cellular stress.	true	true	true	true	true	7,401
0	DISCUSSION	1	31	[ "r16", "r18", "r30", "r31", "r21", "r31", "r32", "r17", "r33", "r2", "r3", "r20", "r21", "r34", "r35", "r2", "r3", "r20", "r21" ]	18,443,205	pmid-10723801\|pmid-14597638\|pmid-17303919\|pmid-10195896\|pmid-11489937\|pmid-10195896\|pmid-10195897\|pmid-10823818\|pmid-9346485\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937\|pmid-15951441\|pmid-16505240\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937	For example, deletion of IKKα (IKKα−/−) causes limb deformities (31), whereas deletion of IKKβ (IKKβ−/−) is lethal in mouse embryos (32).	[ "16", "18", "30", "31", "21", "31", "32", "17", "33", "2", "3", "20", "21", "34", "35", "2", "3", "20", "21" ]	137	42,700	1	false	For example, deletion of IKKα (IKKα−/−) causes limb deformities, whereas deletion of IKKβ (IKKβ−/−) is lethal in mouse embryos.	[ "31", "32" ]	For example, deletion of IKKα (IKKα−/−) causes limb deformities, whereas deletion of IKKβ (IKKβ−/−) is lethal in mouse embryos.	true	true	true	true	true	7,401
0	DISCUSSION	1	16	[ "r16", "r18", "r30", "r31", "r21", "r31", "r32", "r17", "r33", "r2", "r3", "r20", "r21", "r34", "r35", "r2", "r3", "r20", "r21" ]	18,443,205	pmid-10723801\|pmid-14597638\|pmid-17303919\|pmid-10195896\|pmid-11489937\|pmid-10195896\|pmid-10195897\|pmid-10823818\|pmid-9346485\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937\|pmid-15951441\|pmid-16505240\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937	Of the two catalytic subunits, IKKβ is considered to be the main regulator of NF-κB function because of its higher activity (∼30-fold) toward IκBα (17,33).	[ "16", "18", "30", "31", "21", "31", "32", "17", "33", "2", "3", "20", "21", "34", "35", "2", "3", "20", "21" ]	155	42,701	0	false	Of the two catalytic subunits, IKKβ is considered to be the main regulator of NF-κB function because of its higher activity toward IκBα.	[ "∼30-fold", "17,33" ]	Of the two catalytic subunits, IKKβ is considered to be the main regulator of NF-κB function because of its higher activity toward IκBα.	true	true	true	true	true	7,401
0	DISCUSSION	1	16	[ "r16", "r18", "r30", "r31", "r21", "r31", "r32", "r17", "r33", "r2", "r3", "r20", "r21", "r34", "r35", "r2", "r3", "r20", "r21" ]	18,443,205	pmid-10723801\|pmid-14597638\|pmid-17303919\|pmid-10195896\|pmid-11489937\|pmid-10195896\|pmid-10195897\|pmid-10823818\|pmid-9346485\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937\|pmid-15951441\|pmid-16505240\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937	Recent evidence underscores a central role of IKKβ in insulin sensitivity and type 2 diabetes pathogenesis (2,3,20,21,34,35).	[ "16", "18", "30", "31", "21", "31", "32", "17", "33", "2", "3", "20", "21", "34", "35", "2", "3", "20", "21" ]	125	42,702	0	false	Recent evidence underscores a central role of IKKβ in insulin sensitivity and type 2 diabetes pathogenesis.	[ "2,3,20,21,34,35" ]	Recent evidence underscores a central role of IKKβ in insulin sensitivity and type 2 diabetes pathogenesis.	true	true	true	true	true	7,401
0	DISCUSSION	1	16	[ "r16", "r18", "r30", "r31", "r21", "r31", "r32", "r17", "r33", "r2", "r3", "r20", "r21", "r34", "r35", "r2", "r3", "r20", "r21" ]	18,443,205	pmid-10723801\|pmid-14597638\|pmid-17303919\|pmid-10195896\|pmid-11489937\|pmid-10195896\|pmid-10195897\|pmid-10823818\|pmid-9346485\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937\|pmid-15951441\|pmid-16505240\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937	High doses of salicylates, which repress IKKβ activity, reverse hyperglycemia, hyperinsulinemia, and dyslipidemia in obese rodents by increasing insulin sensitivity (2,3,20,21).	[ "16", "18", "30", "31", "21", "31", "32", "17", "33", "2", "3", "20", "21", "34", "35", "2", "3", "20", "21" ]	177	42,703	0	false	High doses of salicylates, which repress IKKβ activity, reverse hyperglycemia, hyperinsulinemia, and dyslipidemia in obese rodents by increasing insulin sensitivity.	[ "2,3,20,21" ]	High doses of salicylates, which repress IKKβ activity, reverse hyperglycemia, hyperinsulinemia, and dyslipidemia in obese rodents by increasing insulin sensitivity.	true	true	true	true	true	7,401
0	DISCUSSION	1	16	[ "r16", "r18", "r30", "r31", "r21", "r31", "r32", "r17", "r33", "r2", "r3", "r20", "r21", "r34", "r35", "r2", "r3", "r20", "r21" ]	18,443,205	pmid-10723801\|pmid-14597638\|pmid-17303919\|pmid-10195896\|pmid-11489937\|pmid-10195896\|pmid-10195897\|pmid-10823818\|pmid-9346485\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937\|pmid-15951441\|pmid-16505240\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937	Consequently, we determined the role of IKKβ in insulin action on glucose uptake using siRNA-mediated gene silencing.	[ "16", "18", "30", "31", "21", "31", "32", "17", "33", "2", "3", "20", "21", "34", "35", "2", "3", "20", "21" ]	117	42,704	0	false	Consequently, we determined the role of IKKβ in insulin action on glucose uptake using siRNA-mediated gene silencing.	[]	Consequently, we determined the role of IKKβ in insulin action on glucose uptake using siRNA-mediated gene silencing.	true	true	true	true	true	7,401
0	DISCUSSION	1	16	[ "r16", "r18", "r30", "r31", "r21", "r31", "r32", "r17", "r33", "r2", "r3", "r20", "r21", "r34", "r35", "r2", "r3", "r20", "r21" ]	18,443,205	pmid-10723801\|pmid-14597638\|pmid-17303919\|pmid-10195896\|pmid-11489937\|pmid-10195896\|pmid-10195897\|pmid-10823818\|pmid-9346485\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937\|pmid-15951441\|pmid-16505240\|pmid-9817203\|pmid-11533494\|pmid-12021247\|pmid-11489937	We provide evidence that IKKβ plays a role in TNF-α–induced impairments in insulin action on Akt signaling and glucose uptake and metabolism in human skeletal muscle.	[ "16", "18", "30", "31", "21", "31", "32", "17", "33", "2", "3", "20", "21", "34", "35", "2", "3", "20", "21" ]	166	42,705	0	false	We provide evidence that IKKβ plays a role in TNF-α–induced impairments in insulin action on Akt signaling and glucose uptake and metabolism in human skeletal muscle.	[]	We provide evidence that IKKβ plays a role in TNF-α–induced impairments in insulin action on Akt signaling and glucose uptake and metabolism in human skeletal muscle.	true	true	true	true	true	7,401
1	DISCUSSION	1	36	[ "r36", "r37", "r16", "r38", "r37", "r37", "r39", "r40" ]	18,443,205	pmid-15685173\|pmid-12431991\|pmid-10723801\|pmid-11134171\|pmid-12431991\|pmid-12431991\|pmid-17303713\|pmid-15479644	TNF-α has a biphasic response to NF-κB, which is required for cytokine-induced skeletal muscle damage and wasting/cachexia (36,37).	[ "36", "37", "16", "38", "37", "37", "39", "40" ]	131	42,706	0	false	TNF-α has a biphasic response to NF-κB, which is required for cytokine-induced skeletal muscle damage and wasting/cachexia.	[ "36,37" ]	TNF-α has a biphasic response to NF-κB, which is required for cytokine-induced skeletal muscle damage and wasting/cachexia.	true	true	true	true	true	7,402
1	DISCUSSION	1	36	[ "r36", "r37", "r16", "r38", "r37", "r37", "r39", "r40" ]	18,443,205	pmid-15685173\|pmid-12431991\|pmid-10723801\|pmid-11134171\|pmid-12431991\|pmid-12431991\|pmid-17303713\|pmid-15479644	Cytokines activate the IKK complex, leading to phosphorylation of IκBα on Ser32 and Ser36.	[ "36", "37", "16", "38", "37", "37", "39", "40" ]	90	42,707	0	false	Cytokines activate the IKK complex, leading to phosphorylation of IκBα on Ser32 and Ser36.	[]	Cytokines activate the IKK complex, leading to phosphorylation of IκBα on Ser32 and Ser36.	true	true	true	true	true	7,402
1	DISCUSSION	1	16	[ "r36", "r37", "r16", "r38", "r37", "r37", "r39", "r40" ]	18,443,205	pmid-15685173\|pmid-12431991\|pmid-10723801\|pmid-11134171\|pmid-12431991\|pmid-12431991\|pmid-17303713\|pmid-15479644	Phosphorylation of these residues causes polyubiquitination and subsequent degradation of IκBα by proteosomes (16).	[ "36", "37", "16", "38", "37", "37", "39", "40" ]	115	42,708	1	false	Phosphorylation of these residues causes polyubiquitination and subsequent degradation of IκBα by proteosomes.	[ "16" ]	Phosphorylation of these residues causes polyubiquitination and subsequent degradation of IκBα by proteosomes.	true	true	true	true	true	7,402
1	DISCUSSION	1	38	[ "r36", "r37", "r16", "r38", "r37", "r37", "r39", "r40" ]	18,443,205	pmid-15685173\|pmid-12431991\|pmid-10723801\|pmid-11134171\|pmid-12431991\|pmid-12431991\|pmid-17303713\|pmid-15479644	The breakdown of IκBα leads to the release and nuclear translocation of NF-κB, where it binds to target genes and drives the expression of cytokines, including TNF-α, interleukin-6, and interleukin-1β (38).	[ "36", "37", "16", "38", "37", "37", "39", "40" ]	206	42,709	1	false	The breakdown of IκBα leads to the release and nuclear translocation of NF-κB, where it binds to target genes and drives the expression of cytokines, including TNF-α, interleukin-6, and interleukin-1β.	[ "38" ]	The breakdown of IκBα leads to the release and nuclear translocation of NF-κB, where it binds to target genes and drives the expression of cytokines, including TNF-α, interleukin-6, and interleukin-1β.	true	true	true	true	true	7,402
1	DISCUSSION	1	36	[ "r36", "r37", "r16", "r38", "r37", "r37", "r39", "r40" ]	18,443,205	pmid-15685173\|pmid-12431991\|pmid-10723801\|pmid-11134171\|pmid-12431991\|pmid-12431991\|pmid-17303713\|pmid-15479644	Here, we report that a 2-h TNF-α exposure of cultured myotubes decreased Iκβα protein content, indicating that Iκβα is targeted for degradation after cytokine exposure.	[ "36", "37", "16", "38", "37", "37", "39", "40" ]	168	42,710	0	false	Here, we report that a 2-h TNF-α exposure of cultured myotubes decreased Iκβα protein content, indicating that Iκβα is targeted for degradation after cytokine exposure.	[]	Here, we report that a 2-h TNF-α exposure of cultured myotubes decreased Iκβα protein content, indicating that Iκβα is targeted for degradation after cytokine exposure.	true	true	true	true	true	7,402
1	DISCUSSION	1	37	[ "r36", "r37", "r16", "r38", "r37", "r37", "r39", "r40" ]	18,443,205	pmid-15685173\|pmid-12431991\|pmid-10723801\|pmid-11134171\|pmid-12431991\|pmid-12431991\|pmid-17303713\|pmid-15479644	This finding is consistent with the first transient phase of TNF-α–mediated activation of NF-κB (37).	[ "36", "37", "16", "38", "37", "37", "39", "40" ]	101	42,711	1	false	This finding is consistent with the first transient phase of TNF-α–mediated activation of NF-κB.	[ "37" ]	This finding is consistent with the first transient phase of TNF-α–mediated activation of NF-κB.	true	true	true	true	true	7,402
1	DISCUSSION	1	36	[ "r36", "r37", "r16", "r38", "r37", "r37", "r39", "r40" ]	18,443,205	pmid-15685173\|pmid-12431991\|pmid-10723801\|pmid-11134171\|pmid-12431991\|pmid-12431991\|pmid-17303713\|pmid-15479644	The siRNA-mediated reduction of IKKβ prevented the TNF-α effect on Iκβα degradation.	[ "36", "37", "16", "38", "37", "37", "39", "40" ]	84	42,712	0	false	The siRNA-mediated reduction of IKKβ prevented the TNF-α effect on Iκβα degradation.	[]	The siRNA-mediated reduction of IKKβ prevented the TNF-α effect on Iκβα degradation.	true	true	true	true	true	7,402
1	DISCUSSION	1	36	[ "r36", "r37", "r16", "r38", "r37", "r37", "r39", "r40" ]	18,443,205	pmid-15685173\|pmid-12431991\|pmid-10723801\|pmid-11134171\|pmid-12431991\|pmid-12431991\|pmid-17303713\|pmid-15479644	Skeletal muscle wasting/cachexia, due to accelerated protein degradation through ubiquitin-dependent proteolysis, occurs in a manner analogous to IKKβ-mediated degradation of IκBα.	[ "36", "37", "16", "38", "37", "37", "39", "40" ]	180	42,713	0	false	Skeletal muscle wasting/cachexia, due to accelerated protein degradation through ubiquitin-dependent proteolysis, occurs in a manner analogous to IKKβ-mediated degradation of IκBα.	[]	Skeletal muscle wasting/cachexia, due to accelerated protein degradation through ubiquitin-dependent proteolysis, occurs in a manner analogous to IKKβ-mediated degradation of IκBα.	true	true	true	true	true	7,402
1	DISCUSSION	1	36	[ "r36", "r37", "r16", "r38", "r37", "r37", "r39", "r40" ]	18,443,205	pmid-15685173\|pmid-12431991\|pmid-10723801\|pmid-11134171\|pmid-12431991\|pmid-12431991\|pmid-17303713\|pmid-15479644	Genetic inhibition of the IKKβ/NF-κB/MuRF1 pathway or through pharmacological therapeutics, such as salicylates to inhibit IKKβ activity, rescues the skeletal muscle-wasting phenotype (37,39,40).	[ "36", "37", "16", "38", "37", "37", "39", "40" ]	195	42,714	0	false	Genetic inhibition of the IKKβ/NF-κB/MuRF1 pathway or through pharmacological therapeutics, such as salicylates to inhibit IKKβ activity, rescues the skeletal muscle-wasting phenotype.	[ "37,39,40" ]	Genetic inhibition of the IKKβ/NF-κB/MuRF1 pathway or through pharmacological therapeutics, such as salicylates to inhibit IKKβ activity, rescues the skeletal muscle-wasting phenotype.	true	true	true	true	true	7,402
1	DISCUSSION	1	36	[ "r36", "r37", "r16", "r38", "r37", "r37", "r39", "r40" ]	18,443,205	pmid-15685173\|pmid-12431991\|pmid-10723801\|pmid-11134171\|pmid-12431991\|pmid-12431991\|pmid-17303713\|pmid-15479644	In the current study, skeletal muscle morphology was not altered by either TNF-α exposure or siRNA-mediated gene silencing of IKKβ.	[ "36", "37", "16", "38", "37", "37", "39", "40" ]	131	42,715	0	false	In the current study, skeletal muscle morphology was not altered by either TNF-α exposure or siRNA-mediated gene silencing of IKKβ.	[]	In the current study, skeletal muscle morphology was not altered by either TNF-α exposure or siRNA-mediated gene silencing of IKKβ.	true	true	true	true	true	7,402
1	DISCUSSION	1	36	[ "r36", "r37", "r16", "r38", "r37", "r37", "r39", "r40" ]	18,443,205	pmid-15685173\|pmid-12431991\|pmid-10723801\|pmid-11134171\|pmid-12431991\|pmid-12431991\|pmid-17303713\|pmid-15479644	However, our experiments were limited to a short-term (first phase) TNF-α exposure, and we did not directly test whether IKKβ siRNA would modify culture growth in the presence of a long-term (second phase)	[ "36", "37", "16", "38", "37", "37", "39", "40" ]	205	42,716	0	false	However, our experiments were limited to a short-term (first phase) TNF-α exposure, and we did not directly test whether IKKβ siRNA would modify culture growth in the presence of a long-term (second phase)	[]	However, our experiments were limited to a short-term (first phase) TNF-α exposure, and we did not directly test whether IKKβ siRNA would modify culture growth in the presence of a long-term (second phase)	true	true	false	true	false	7,402
1	DISCUSSION	1	36	[ "r36", "r37", "r16", "r38", "r37", "r37", "r39", "r40" ]	18,443,205	pmid-15685173\|pmid-12431991\|pmid-10723801\|pmid-11134171\|pmid-12431991\|pmid-12431991\|pmid-17303713\|pmid-15479644	TNF-α exposure.	[ "36", "37", "16", "38", "37", "37", "39", "40" ]	15	42,717	0	false	TNF-α exposure.	[]	TNF-α exposure.	true	true	true	true	true	7,402
2	DISCUSSION	1	1	[ "r1", "r41", "r42", "r22", "r5", "r6", "r35", "r20", "r21", "r3", "r20", "r21", "r43", "r44" ]	18,443,205	pmid-16186396\|pmid-9832430\|pmid-17141630\|pmid-17227768\|pmid-16823477\|pmid-12606524\|pmid-16505240\|pmid-12021247\|pmid-11489937\|pmid-11533494\|pmid-12021247\|pmid-11489937\|pmid-17959861\|pmid-17317777	TNF-α directly induces skeletal muscle insulin resistance in vivo in healthy humans (1) and rodents (41,42) and in vitro in cultured myotubes (22).	[ "1", "41", "42", "22", "5", "6", "35", "20", "21", "3", "20", "21", "43", "44" ]	147	42,718	1	false	TNF-α directly induces skeletal muscle insulin resistance in vivo in healthy humans and rodents and in vitro in cultured myotubes.	[ "1", "41,42", "22" ]	TNF-α directly induces skeletal muscle insulin resistance in vivo in healthy humans and rodents and in vitro in cultured myotubes.	true	true	true	true	true	7,403

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