Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
paragraph_index
int64
sec
string
p_has_citation
int64
cites
string
citeids
list
pmid
int64
cited_id
string
sentences
string
all_sent_cites
list
sent_len
int64
sentence_batch_index
int64
sent_has_citation
float64
qc_fail
bool
cited_sentence
string
cites_in_sentence
list
cln_sentence
string
is_cap
bool
is_alpha
bool
ends_wp
bool
cit_qc
bool
lgtm
bool
__index_level_0__
int64
1
DISCUSSION
1
16
[ "B16", "B11" ]
20,007,154
pmid-7596824|pmid-7819208|pmid-9862797|NA|pmid-18954091|NA|NA
Nevertheless, some trends can be mentioned.
[ "16", "11" ]
43
42,419
0
false
Nevertheless, some trends can be mentioned.
[]
Nevertheless, some trends can be mentioned.
true
true
true
true
true
7,353
1
DISCUSSION
1
16
[ "B16", "B11" ]
20,007,154
pmid-7596824|pmid-7819208|pmid-9862797|NA|pmid-18954091|NA|NA
Positions located on the 5′ side of a G in the third strand were more likely to accommodate an adenine than those located on the 3′ side.
[ "16", "11" ]
137
42,420
0
false
Positions located on the 5′ side of a G in the third strand were more likely to accommodate an adenine than those located on the 3′ side.
[]
Positions located on the 5′ side of a G in the third strand were more likely to accommodate an adenine than those located on the 3′ side.
true
true
true
true
true
7,353
1
DISCUSSION
1
16
[ "B16", "B11" ]
20,007,154
pmid-7596824|pmid-7819208|pmid-9862797|NA|pmid-18954091|NA|NA
AT base pairs that were surrounded by only AT base pairs were more likely to be recognized by thymines.
[ "16", "11" ]
103
42,421
0
false
AT base pairs that were surrounded by only AT base pairs were more likely to be recognized by thymines.
[]
AT base pairs that were surrounded by only AT base pairs were more likely to be recognized by thymines.
true
true
true
true
true
7,353
1
DISCUSSION
1
16
[ "B16", "B11" ]
20,007,154
pmid-7596824|pmid-7819208|pmid-9862797|NA|pmid-18954091|NA|NA
Only one AT base pair (position 15) seemed to prefer an adenine (85%).
[ "16", "11" ]
70
42,422
0
false
Only one AT base pair (position 15) seemed to prefer an adenine (85%).
[]
Only one AT base pair seemed to prefer an adenine (85%).
true
true
true
true
true
7,353
1
DISCUSSION
1
11
[ "B16", "B11" ]
20,007,154
pmid-7596824|pmid-7819208|pmid-9862797|NA|pmid-18954091|NA|NA
Preference for A or T may be related to the existence of distortions in the third strand at TpG and GpT steps within antiparallel triple helices with GT third strands (11), and/or to preferential binding sites for intercalation of BIQ.
[ "16", "11" ]
235
42,423
1
false
Preference for A or T may be related to the existence of distortions in the third strand at TpG and GpT steps within antiparallel triple helices with GT third strands, and/or to preferential binding sites for intercalation of BIQ.
[ "11" ]
Preference for A or T may be related to the existence of distortions in the third strand at TpG and GpT steps within antiparallel triple helices with GT third strands, and/or to preferential binding sites for intercalation of BIQ.
true
true
true
true
true
7,353
1
DISCUSSION
1
16
[ "B16", "B11" ]
20,007,154
pmid-7596824|pmid-7819208|pmid-9862797|NA|pmid-18954091|NA|NA
It is also possible that the selection process favours sequences that do not fold into competing structures.
[ "16", "11" ]
108
42,424
0
false
It is also possible that the selection process favours sequences that do not fold into competing structures.
[]
It is also possible that the selection process favours sequences that do not fold into competing structures.
true
true
true
true
true
7,353
1
DISCUSSION
1
16
[ "B16", "B11" ]
20,007,154
pmid-7596824|pmid-7819208|pmid-9862797|NA|pmid-18954091|NA|NA
We were not able to explain the presence of adenine at specific positions by such a mechanism.
[ "16", "11" ]
94
42,425
0
false
We were not able to explain the presence of adenine at specific positions by such a mechanism.
[]
We were not able to explain the presence of adenine at specific positions by such a mechanism.
true
true
true
true
true
7,353
1
DISCUSSION
1
16
[ "B16", "B11" ]
20,007,154
pmid-7596824|pmid-7819208|pmid-9862797|NA|pmid-18954091|NA|NA
We measured the dissociation constant for clone 20, which corresponded to the consensus sequence involving G, T and a single A in the triplex forming region.
[ "16", "11" ]
157
42,426
0
false
We measured the dissociation constant for clone 20, which corresponded to the consensus sequence involving G, T and a single A in the triplex forming region.
[]
We measured the dissociation constant for clone 20, which corresponded to the consensus sequence involving G, T and a single A in the triplex forming region.
true
true
true
true
true
7,353
1
DISCUSSION
1
16
[ "B16", "B11" ]
20,007,154
pmid-7596824|pmid-7819208|pmid-9862797|NA|pmid-18954091|NA|NA
The affinity of this sequence for the target was slightly higher than that of clone 19, which has the highest number of adenines.
[ "16", "11" ]
129
42,427
0
false
The affinity of this sequence for the target was slightly higher than that of clone 19, which has the highest number of adenines.
[]
The affinity of this sequence for the target was slightly higher than that of clone 19, which has the highest number of adenines.
true
true
true
true
true
7,353
1
DISCUSSION
1
16
[ "B16", "B11" ]
20,007,154
pmid-7596824|pmid-7819208|pmid-9862797|NA|pmid-18954091|NA|NA
This difference is probably not very significant, and may be explained by the effects of adjacent sequences.
[ "16", "11" ]
108
42,428
0
false
This difference is probably not very significant, and may be explained by the effects of adjacent sequences.
[]
This difference is probably not very significant, and may be explained by the effects of adjacent sequences.
true
true
true
true
true
7,353
1
DISCUSSION
1
16
[ "B16", "B11" ]
20,007,154
pmid-7596824|pmid-7819208|pmid-9862797|NA|pmid-18954091|NA|NA
Experiments performed with 20-mer oligonucleotides did not show significant differences between the binding affinities of the various selected sequences.
[ "16", "11" ]
153
42,429
0
false
Experiments performed with 20-mer oligonucleotides did not show significant differences between the binding affinities of the various selected sequences.
[]
Experiments performed with 20-mer oligonucleotides did not show significant differences between the binding affinities of the various selected sequences.
true
true
true
true
true
7,353
1
DISCUSSION
1
16
[ "B16", "B11" ]
20,007,154
pmid-7596824|pmid-7819208|pmid-9862797|NA|pmid-18954091|NA|NA
Although two pyrimidine rich oligonucleotides were present among the selected sequences, binding of these oligonucleotides could not be detected.
[ "16", "11" ]
145
42,430
0
false
Although two pyrimidine rich oligonucleotides were present among the selected sequences, binding of these oligonucleotides could not be detected.
[]
Although two pyrimidine rich oligonucleotides were present among the selected sequences, binding of these oligonucleotides could not be detected.
true
true
true
true
true
7,353
1
DISCUSSION
1
16
[ "B16", "B11" ]
20,007,154
pmid-7596824|pmid-7819208|pmid-9862797|NA|pmid-18954091|NA|NA
The binding scheme and the reason for the presence of these sequences remains to be investigated.
[ "16", "11" ]
97
42,431
0
false
The binding scheme and the reason for the presence of these sequences remains to be investigated.
[]
The binding scheme and the reason for the presence of these sequences remains to be investigated.
true
true
true
true
true
7,353
2
DISCUSSION
1
38
[ "B38", "B39" ]
20,007,154
pmid-10637355|pmid-1609278|NA|pmid-9520410|NA|pmid-8639533|pmid-8604349|pmid-9547278|pmid-10657289|pmid-16289104
Interesting questions are raised by the issue of our selections.
[ "38", "39" ]
64
42,432
0
false
Interesting questions are raised by the issue of our selections.
[]
Interesting questions are raised by the issue of our selections.
true
true
true
true
true
7,354
2
DISCUSSION
1
38
[ "B38", "B39" ]
20,007,154
pmid-10637355|pmid-1609278|NA|pmid-9520410|NA|pmid-8639533|pmid-8604349|pmid-9547278|pmid-10657289|pmid-16289104
One may wonder why only TFOs were selected.
[ "38", "39" ]
43
42,433
0
false
One may wonder why only TFOs were selected.
[]
One may wonder why only TFOs were selected.
true
true
true
true
true
7,354
2
DISCUSSION
1
38
[ "B38", "B39" ]
20,007,154
pmid-10637355|pmid-1609278|NA|pmid-9520410|NA|pmid-8639533|pmid-8604349|pmid-9547278|pmid-10657289|pmid-16289104
Given the tremendous variety of structures that are adopted by aptamers for the recognition of small molecules [see ref.
[ "38", "39" ]
120
42,434
0
false
Given the tremendous variety of structures that are adopted by aptamers for the recognition of small molecules [see ref.
[]
Given the tremendous variety of structures that are adopted by aptamers for the recognition of small molecules [see ref.
true
true
true
true
true
7,354
2
DISCUSSION
1
38
[ "B38", "B39" ]
20,007,154
pmid-10637355|pmid-1609278|NA|pmid-9520410|NA|pmid-8639533|pmid-8604349|pmid-9547278|pmid-10657289|pmid-16289104
(38) for review], one may expect the possibility for recognition of a DNA–intercalator complex by a selected oligonucleotide within a new structural framework.
[ "38", "39" ]
159
42,435
1
false
for review], one may expect the possibility for recognition of a DNA–intercalator complex by a selected oligonucleotide within a new structural framework.
[ "38" ]
for review], one may expect the possibility for recognition of a DNA–intercalator complex by a selected oligonucleotide within a new structural framework.
false
true
true
true
false
7,354
2
DISCUSSION
1
38
[ "B38", "B39" ]
20,007,154
pmid-10637355|pmid-1609278|NA|pmid-9520410|NA|pmid-8639533|pmid-8604349|pmid-9547278|pmid-10657289|pmid-16289104
Aptamers may indeed potentially establish stacking interactions with planar aliphatic rings as well as electrostatic interactions with the side chains.
[ "38", "39" ]
151
42,436
0
false
Aptamers may indeed potentially establish stacking interactions with planar aliphatic rings as well as electrostatic interactions with the side chains.
[]
Aptamers may indeed potentially establish stacking interactions with planar aliphatic rings as well as electrostatic interactions with the side chains.
true
true
true
true
true
7,354
2
DISCUSSION
1
39
[ "B38", "B39" ]
20,007,154
pmid-10637355|pmid-1609278|NA|pmid-9520410|NA|pmid-8639533|pmid-8604349|pmid-9547278|pmid-10657289|pmid-16289104
It should be noted that aptamer can recognize chemical moieties as small as ethanolamine (39), which resembles the side chain of our triplex stabilizing agent.
[ "38", "39" ]
159
42,437
1
false
It should be noted that aptamer can recognize chemical moieties as small as ethanolamine, which resembles the side chain of our triplex stabilizing agent.
[ "39" ]
It should be noted that aptamer can recognize chemical moieties as small as ethanolamine, which resembles the side chain of our triplex stabilizing agent.
true
true
true
true
true
7,354
2
DISCUSSION
1
38
[ "B38", "B39" ]
20,007,154
pmid-10637355|pmid-1609278|NA|pmid-9520410|NA|pmid-8639533|pmid-8604349|pmid-9547278|pmid-10657289|pmid-16289104
Despite the presence of this large intercalating compound in our selection scheme, no DNA binding solutions that differed from triple-helix formation were discovered.
[ "38", "39" ]
166
42,438
0
false
Despite the presence of this large intercalating compound in our selection scheme, no DNA binding solutions that differed from triple-helix formation were discovered.
[]
Despite the presence of this large intercalating compound in our selection scheme, no DNA binding solutions that differed from triple-helix formation were discovered.
true
true
true
true
true
7,354
2
DISCUSSION
1
38
[ "B38", "B39" ]
20,007,154
pmid-10637355|pmid-1609278|NA|pmid-9520410|NA|pmid-8639533|pmid-8604349|pmid-9547278|pmid-10657289|pmid-16289104
Several factors may have biased selection toward recovery of sequences that bound via triple-helix formation: the chosen DNA contained an oligopurine–oligopyrimidine stretch and therefore was typically suited to form conventional triple helices with an appropriate DNA, and conventional triple helix formation may afford...
[ "38", "39" ]
361
42,439
0
false
Several factors may have biased selection toward recovery of sequences that bound via triple-helix formation: the chosen DNA contained an oligopurine–oligopyrimidine stretch and therefore was typically suited to form conventional triple helices with an appropriate DNA, and conventional triple helix formation may afford...
[]
Several factors may have biased selection toward recovery of sequences that bound via triple-helix formation: the chosen DNA contained an oligopurine–oligopyrimidine stretch and therefore was typically suited to form conventional triple helices with an appropriate DNA, and conventional triple helix formation may afford...
true
true
true
true
true
7,354
2
DISCUSSION
1
38
[ "B38", "B39" ]
20,007,154
pmid-10637355|pmid-1609278|NA|pmid-9520410|NA|pmid-8639533|pmid-8604349|pmid-9547278|pmid-10657289|pmid-16289104
The size of the pool that we used (250 pmol, i.e.
[ "38", "39" ]
49
42,440
0
false
The size of the pool that we used (250 pmol, i.e.
[]
The size of the pool that we used (250 pmol, i.e.
true
true
true
true
true
7,354
2
DISCUSSION
1
38
[ "B38", "B39" ]
20,007,154
pmid-10637355|pmid-1609278|NA|pmid-9520410|NA|pmid-8639533|pmid-8604349|pmid-9547278|pmid-10657289|pmid-16289104
∼1.5 × 1014 molecules) is sufficient to screen all possible sequences with a length of 22 nt (each sequence is present on average 10 times).
[ "38", "39" ]
140
42,441
0
false
∼1.5 × 1014 molecules) is sufficient to screen all possible sequences with a length of 22 nt (each sequence is present on average 10 times).
[]
∼1.5 × 1014 molecules) is sufficient to screen all possible sequences with a length of 22 nt (each sequence is present on average 10 times).
false
false
true
true
false
7,354
2
DISCUSSION
1
38
[ "B38", "B39" ]
20,007,154
pmid-10637355|pmid-1609278|NA|pmid-9520410|NA|pmid-8639533|pmid-8604349|pmid-9547278|pmid-10657289|pmid-16289104
All the selected sequences seemed to provide maximal recognition with the same length of 20 nucleotides, as there appears to be little nucleotide sequence conservation outside of the canonical recognition sequence.
[ "38", "39" ]
214
42,442
0
false
All the selected sequences seemed to provide maximal recognition with the same length of 20 nucleotides, as there appears to be little nucleotide sequence conservation outside of the canonical recognition sequence.
[]
All the selected sequences seemed to provide maximal recognition with the same length of 20 nucleotides, as there appears to be little nucleotide sequence conservation outside of the canonical recognition sequence.
true
true
true
true
true
7,354
2
DISCUSSION
1
38
[ "B38", "B39" ]
20,007,154
pmid-10637355|pmid-1609278|NA|pmid-9520410|NA|pmid-8639533|pmid-8604349|pmid-9547278|pmid-10657289|pmid-16289104
This suggests that additional interactions involving two additional nucleotides did not improve binding sufficiently to make a difference.
[ "38", "39" ]
138
42,443
0
false
This suggests that additional interactions involving two additional nucleotides did not improve binding sufficiently to make a difference.
[]
This suggests that additional interactions involving two additional nucleotides did not improve binding sufficiently to make a difference.
true
true
true
true
true
7,354
2
DISCUSSION
1
38
[ "B38", "B39" ]
20,007,154
pmid-10637355|pmid-1609278|NA|pmid-9520410|NA|pmid-8639533|pmid-8604349|pmid-9547278|pmid-10657289|pmid-16289104
This does not exclude that better solutions involving more than 23 nucleotides may exist and have been missed in our screening.
[ "38", "39" ]
127
42,444
0
false
This does not exclude that better solutions involving more than 23 nucleotides may exist and have been missed in our screening.
[]
This does not exclude that better solutions involving more than 23 nucleotides may exist and have been missed in our screening.
true
true
true
true
true
7,354
2
DISCUSSION
1
38
[ "B38", "B39" ]
20,007,154
pmid-10637355|pmid-1609278|NA|pmid-9520410|NA|pmid-8639533|pmid-8604349|pmid-9547278|pmid-10657289|pmid-16289104
One may also not exclude that some binding solutions other than the representatives of the triple helix may have been present in the oligonucleotide pool solution but were eliminated due to a lower affinity.
[ "38", "39" ]
207
42,445
0
false
One may also not exclude that some binding solutions other than the representatives of the triple helix may have been present in the oligonucleotide pool solution but were eliminated due to a lower affinity.
[]
One may also not exclude that some binding solutions other than the representatives of the triple helix may have been present in the oligonucleotide pool solution but were eliminated due to a lower affinity.
true
true
true
true
true
7,354
2
DISCUSSION
1
38
[ "B38", "B39" ]
20,007,154
pmid-10637355|pmid-1609278|NA|pmid-9520410|NA|pmid-8639533|pmid-8604349|pmid-9547278|pmid-10657289|pmid-16289104
Such other solutions would be recovered by using a target with a much shorter or no oligopurine–oligopyrimidine stretch at all.
[ "38", "39" ]
127
42,446
0
false
Such other solutions would be recovered by using a target with a much shorter or no oligopurine–oligopyrimidine stretch at all.
[]
Such other solutions would be recovered by using a target with a much shorter or no oligopurine–oligopyrimidine stretch at all.
true
true
true
true
true
7,354
3
DISCUSSION
1
40
[ "B40", "B41" ]
20,007,154
pmid-2200121|pmid-1697402|pmid-10995196|pmid-10960261|pmid-17634987|pmid-17627883|pmid-8855239|pmid-10449422|pmid-12867086|pmid-15681618|pmid-7506827|pmid-7529405
One may also wonder why we did recover only TFOs within the antiparallel motif, contrary to previous studies.
[ "40", "41" ]
109
42,447
0
false
One may also wonder why we did recover only TFOs within the antiparallel motif, contrary to previous studies.
[]
One may also wonder why we did recover only TFOs within the antiparallel motif, contrary to previous studies.
true
true
true
true
true
7,355
3
DISCUSSION
1
40
[ "B40", "B41" ]
20,007,154
pmid-2200121|pmid-1697402|pmid-10995196|pmid-10960261|pmid-17634987|pmid-17627883|pmid-8855239|pmid-10449422|pmid-12867086|pmid-15681618|pmid-7506827|pmid-7529405
Our target sequence does not contain long stretches of GC base pairs, and the proportion of GC base pairs (35%), should in principle be favourable for the binding of pyrimidine rich TFOs.
[ "40", "41" ]
187
42,448
0
false
Our target sequence does not contain long stretches of GC base pairs, and the proportion of GC base pairs (35%), should in principle be favourable for the binding of pyrimidine rich TFOs.
[]
Our target sequence does not contain long stretches of GC base pairs, and the proportion of GC base pairs (35%), should in principle be favourable for the binding of pyrimidine rich TFOs.
true
true
true
true
true
7,355
3
DISCUSSION
1
40
[ "B40", "B41" ]
20,007,154
pmid-2200121|pmid-1697402|pmid-10995196|pmid-10960261|pmid-17634987|pmid-17627883|pmid-8855239|pmid-10449422|pmid-12867086|pmid-15681618|pmid-7506827|pmid-7529405
The issue of our selection may result from a much better stability of antiparallel TFOs in the presence of BIQ.
[ "40", "41" ]
111
42,449
0
false
The issue of our selection may result from a much better stability of antiparallel TFOs in the presence of BIQ.
[]
The issue of our selection may result from a much better stability of antiparallel TFOs in the presence of BIQ.
true
true
true
true
true
7,355
3
DISCUSSION
1
40
[ "B40", "B41" ]
20,007,154
pmid-2200121|pmid-1697402|pmid-10995196|pmid-10960261|pmid-17634987|pmid-17627883|pmid-8855239|pmid-10449422|pmid-12867086|pmid-15681618|pmid-7506827|pmid-7529405
It may also be due to the presence of magnesium, which favours the antiparallel motif.
[ "40", "41" ]
86
42,450
0
false
It may also be due to the presence of magnesium, which favours the antiparallel motif.
[]
It may also be due to the presence of magnesium, which favours the antiparallel motif.
true
true
true
true
true
7,355
3
DISCUSSION
1
40
[ "B40", "B41" ]
20,007,154
pmid-2200121|pmid-1697402|pmid-10995196|pmid-10960261|pmid-17634987|pmid-17627883|pmid-8855239|pmid-10449422|pmid-12867086|pmid-15681618|pmid-7506827|pmid-7529405
Other parameters, such as binding kinetics, may also be important in such experiments.
[ "40", "41" ]
86
42,451
0
false
Other parameters, such as binding kinetics, may also be important in such experiments.
[]
Other parameters, such as binding kinetics, may also be important in such experiments.
true
true
true
true
true
7,355
3
DISCUSSION
1
40
[ "B40", "B41" ]
20,007,154
pmid-2200121|pmid-1697402|pmid-10995196|pmid-10960261|pmid-17634987|pmid-17627883|pmid-8855239|pmid-10449422|pmid-12867086|pmid-15681618|pmid-7506827|pmid-7529405
The formation of pyrimidine motif triple helices is a slow process, which may have been disfavoured by our fast binding step.
[ "40", "41" ]
125
42,452
0
false
The formation of pyrimidine motif triple helices is a slow process, which may have been disfavoured by our fast binding step.
[]
The formation of pyrimidine motif triple helices is a slow process, which may have been disfavoured by our fast binding step.
true
true
true
true
true
7,355
3
DISCUSSION
1
40
[ "B40", "B41" ]
20,007,154
pmid-2200121|pmid-1697402|pmid-10995196|pmid-10960261|pmid-17634987|pmid-17627883|pmid-8855239|pmid-10449422|pmid-12867086|pmid-15681618|pmid-7506827|pmid-7529405
Further work will be necessary to evaluate how modifications of the selection protocol will affect the repertory of selected sequences.
[ "40", "41" ]
135
42,453
0
false
Further work will be necessary to evaluate how modifications of the selection protocol will affect the repertory of selected sequences.
[]
Further work will be necessary to evaluate how modifications of the selection protocol will affect the repertory of selected sequences.
true
true
true
true
true
7,355
3
DISCUSSION
1
40
[ "B40", "B41" ]
20,007,154
pmid-2200121|pmid-1697402|pmid-10995196|pmid-10960261|pmid-17634987|pmid-17627883|pmid-8855239|pmid-10449422|pmid-12867086|pmid-15681618|pmid-7506827|pmid-7529405
One should also keep in mind that, in addition to slightly acidic conditions, previous studies were aimed at selecting RNA oligonucleotides, which are known to be poorly compatible with the formation of antiparallel triple-helices (40,41).
[ "40", "41" ]
239
42,454
0
false
One should also keep in mind that, in addition to slightly acidic conditions, previous studies were aimed at selecting RNA oligonucleotides, which are known to be poorly compatible with the formation of antiparallel triple-helices.
[ "40,41" ]
One should also keep in mind that, in addition to slightly acidic conditions, previous studies were aimed at selecting RNA oligonucleotides, which are known to be poorly compatible with the formation of antiparallel triple-helices.
true
true
true
true
true
7,355
4
DISCUSSION
1
42
[ "B42" ]
20,007,154
pmid-1716784|pmid-8656424|pmid-19153138
Our SELEX process was performed in the presence of a low molecular weight compound expected to enhance interactions between the target and the oligonucleotide pool.
[ "42" ]
164
42,455
0
false
Our SELEX process was performed in the presence of a low molecular weight compound expected to enhance interactions between the target and the oligonucleotide pool.
[]
Our SELEX process was performed in the presence of a low molecular weight compound expected to enhance interactions between the target and the oligonucleotide pool.
true
true
true
true
true
7,356
4
DISCUSSION
1
42
[ "B42" ]
20,007,154
pmid-1716784|pmid-8656424|pmid-19153138
This is an original strategy which to our knowledge has never been used before.
[ "42" ]
79
42,456
0
false
This is an original strategy which to our knowledge has never been used before.
[]
This is an original strategy which to our knowledge has never been used before.
true
true
true
true
true
7,356
4
DISCUSSION
1
42
[ "B42" ]
20,007,154
pmid-1716784|pmid-8656424|pmid-19153138
The presence of the ligand resulted in selection of oligonucleotides that bound to the target only in the presence of the small molecule, although no counterselection was introduced to remove sequences that would bind in the absence of the compound.
[ "42" ]
249
42,457
0
false
The presence of the ligand resulted in selection of oligonucleotides that bound to the target only in the presence of the small molecule, although no counterselection was introduced to remove sequences that would bind in the absence of the compound.
[]
The presence of the ligand resulted in selection of oligonucleotides that bound to the target only in the presence of the small molecule, although no counterselection was introduced to remove sequences that would bind in the absence of the compound.
true
true
true
true
true
7,356
4
DISCUSSION
1
42
[ "B42" ]
20,007,154
pmid-1716784|pmid-8656424|pmid-19153138
This is likely due to the very high stability of the complexes formed by the target, the ligand and the selected oligonucleotide.
[ "42" ]
129
42,458
0
false
This is likely due to the very high stability of the complexes formed by the target, the ligand and the selected oligonucleotide.
[]
This is likely due to the very high stability of the complexes formed by the target, the ligand and the selected oligonucleotide.
true
true
true
true
true
7,356
4
DISCUSSION
1
42
[ "B42" ]
20,007,154
pmid-1716784|pmid-8656424|pmid-19153138
A great effort has been devoted to the expansion of the catalytic repertoire of nucleic acids by addition of protein like functionalities to the nucleic acids to be selected
[ "42" ]
173
42,459
0
false
A great effort has been devoted to the expansion of the catalytic repertoire of nucleic acids by addition of protein like functionalities to the nucleic acids to be selected
[]
A great effort has been devoted to the expansion of the catalytic repertoire of nucleic acids by addition of protein like functionalities to the nucleic acids to be selected
true
true
false
true
false
7,356
4
DISCUSSION
1
42
[ "B42" ]
20,007,154
pmid-1716784|pmid-8656424|pmid-19153138
and references therein].
[ "42" ]
24
42,460
0
false
and references therein].
[]
and references therein].
false
true
true
true
false
7,356
4
DISCUSSION
1
42
[ "B42" ]
20,007,154
pmid-1716784|pmid-8656424|pmid-19153138
The number of modifications that can be incorporated into aptamers is still limited.
[ "42" ]
84
42,461
0
false
The number of modifications that can be incorporated into aptamers is still limited.
[]
The number of modifications that can be incorporated into aptamers is still limited.
true
true
true
true
true
7,356
4
DISCUSSION
1
42
[ "B42" ]
20,007,154
pmid-1716784|pmid-8656424|pmid-19153138
The use of another functional group, in this case an intercalator, in order to provide these additional functionalities represents an interesting solution to this problem.
[ "42" ]
171
42,462
0
false
The use of another functional group, in this case an intercalator, in order to provide these additional functionalities represents an interesting solution to this problem.
[]
The use of another functional group, in this case an intercalator, in order to provide these additional functionalities represents an interesting solution to this problem.
true
true
true
true
true
7,356
5
DISCUSSION
1
43
[ "B43", "B44", "B19", "B45", "B46", "B10", "B47", "B10", "B48" ]
20,007,154
pmid-15274215|pmid-15911633|pmid-9547278|pmid-9380499|pmid-9685475|pmid-9862797|NA|pmid-9862797|pmid-10454596
Although great progress have been made toward the design of new chemically modified oligonucleotides that permit recognition of a wider variety of sequences by TFOs (43,44), there is still no general solution that is easy to apply to any sequence of interest.
[ "43", "44", "19", "45", "46", "10", "47", "10", "48" ]
259
42,463
0
false
Although great progress have been made toward the design of new chemically modified oligonucleotides that permit recognition of a wider variety of sequences by TFOs, there is still no general solution that is easy to apply to any sequence of interest.
[ "43,44" ]
Although great progress have been made toward the design of new chemically modified oligonucleotides that permit recognition of a wider variety of sequences by TFOs, there is still no general solution that is easy to apply to any sequence of interest.
true
true
true
true
true
7,357
5
DISCUSSION
1
43
[ "B43", "B44", "B19", "B45", "B46", "B10", "B47", "B10", "B48" ]
20,007,154
pmid-15274215|pmid-15911633|pmid-9547278|pmid-9380499|pmid-9685475|pmid-9862797|NA|pmid-9862797|pmid-10454596
Our SELEX approach provides an interesting solution for the design of TFOs for applications that can accommodate the presence of an intercalator.
[ "43", "44", "19", "45", "46", "10", "47", "10", "48" ]
145
42,464
0
false
Our SELEX approach provides an interesting solution for the design of TFOs for applications that can accommodate the presence of an intercalator.
[]
Our SELEX approach provides an interesting solution for the design of TFOs for applications that can accommodate the presence of an intercalator.
true
true
true
true
true
7,357
5
DISCUSSION
1
43
[ "B43", "B44", "B19", "B45", "B46", "B10", "B47", "B10", "B48" ]
20,007,154
pmid-15274215|pmid-15911633|pmid-9547278|pmid-9380499|pmid-9685475|pmid-9862797|NA|pmid-9862797|pmid-10454596
The same selection scheme could by applied to other target DNA sequences, with interesting potential applications.
[ "43", "44", "19", "45", "46", "10", "47", "10", "48" ]
114
42,465
0
false
The same selection scheme could by applied to other target DNA sequences, with interesting potential applications.
[]
The same selection scheme could by applied to other target DNA sequences, with interesting potential applications.
true
true
true
true
true
7,357
5
DISCUSSION
1
43
[ "B43", "B44", "B19", "B45", "B46", "B10", "B47", "B10", "B48" ]
20,007,154
pmid-15274215|pmid-15911633|pmid-9547278|pmid-9380499|pmid-9685475|pmid-9862797|NA|pmid-9862797|pmid-10454596
First, the repertoire of target sequences for triple-helix formation may be extended in the presence of DNA binding agents.
[ "43", "44", "19", "45", "46", "10", "47", "10", "48" ]
123
42,466
0
false
First, the repertoire of target sequences for triple-helix formation may be extended in the presence of DNA binding agents.
[]
First, the repertoire of target sequences for triple-helix formation may be extended in the presence of DNA binding agents.
true
true
true
true
true
7,357
5
DISCUSSION
1
46
[ "B43", "B44", "B19", "B45", "B46", "B10", "B47", "B10", "B48" ]
20,007,154
pmid-15274215|pmid-15911633|pmid-9547278|pmid-9380499|pmid-9685475|pmid-9862797|NA|pmid-9862797|pmid-10454596
It has already been demonstrated that addition of a triplex-stabilizing agent could enhance the formation of triple helices at sites containing inversions within the oligopurine–oligopyrimidine sequence (19,45) or at (GT)n tracts (46).
[ "43", "44", "19", "45", "46", "10", "47", "10", "48" ]
235
42,467
1
false
It has already been demonstrated that addition of a triplex-stabilizing agent could enhance the formation of triple helices at sites containing inversions within the oligopurine–oligopyrimidine sequence or at (GT)n tracts.
[ "19,45", "46" ]
It has already been demonstrated that addition of a triplex-stabilizing agent could enhance the formation of triple helices at sites containing inversions within the oligopurine–oligopyrimidine sequence or at (GT)n tracts.
true
true
true
true
true
7,357
5
DISCUSSION
1
10
[ "B43", "B44", "B19", "B45", "B46", "B10", "B47", "B10", "B48" ]
20,007,154
pmid-15274215|pmid-15911633|pmid-9547278|pmid-9380499|pmid-9685475|pmid-9862797|NA|pmid-9862797|pmid-10454596
Triplex-specific intercalators have also been shown to promote the formation of triple helices which switch from one strand to the other strand of DNA (10).
[ "43", "44", "19", "45", "46", "10", "47", "10", "48" ]
156
42,468
1
false
Triplex-specific intercalators have also been shown to promote the formation of triple helices which switch from one strand to the other strand of DNA.
[ "10" ]
Triplex-specific intercalators have also been shown to promote the formation of triple helices which switch from one strand to the other strand of DNA.
true
true
true
true
true
7,357
5
DISCUSSION
1
47
[ "B43", "B44", "B19", "B45", "B46", "B10", "B47", "B10", "B48" ]
20,007,154
pmid-15274215|pmid-15911633|pmid-9547278|pmid-9380499|pmid-9685475|pmid-9862797|NA|pmid-9862797|pmid-10454596
In such cases, molecular modelling has suggested a code for designing the best switch oligonucleotide (47).
[ "43", "44", "19", "45", "46", "10", "47", "10", "48" ]
107
42,469
1
false
In such cases, molecular modelling has suggested a code for designing the best switch oligonucleotide.
[ "47" ]
In such cases, molecular modelling has suggested a code for designing the best switch oligonucleotide.
true
true
true
true
true
7,357
5
DISCUSSION
1
43
[ "B43", "B44", "B19", "B45", "B46", "B10", "B47", "B10", "B48" ]
20,007,154
pmid-15274215|pmid-15911633|pmid-9547278|pmid-9380499|pmid-9685475|pmid-9862797|NA|pmid-9862797|pmid-10454596
Although this code has received some experimental validation (10,48), our strategy would provide the best oligonucleotide solution for this switch problem.
[ "43", "44", "19", "45", "46", "10", "47", "10", "48" ]
155
42,470
0
false
Although this code has received some experimental validation, our strategy would provide the best oligonucleotide solution for this switch problem.
[ "10,48" ]
Although this code has received some experimental validation, our strategy would provide the best oligonucleotide solution for this switch problem.
true
true
true
true
true
7,357
5
DISCUSSION
1
43
[ "B43", "B44", "B19", "B45", "B46", "B10", "B47", "B10", "B48" ]
20,007,154
pmid-15274215|pmid-15911633|pmid-9547278|pmid-9380499|pmid-9685475|pmid-9862797|NA|pmid-9862797|pmid-10454596
It would also be interesting to perform selections with other DNA binding agents.
[ "43", "44", "19", "45", "46", "10", "47", "10", "48" ]
81
42,471
0
false
It would also be interesting to perform selections with other DNA binding agents.
[]
It would also be interesting to perform selections with other DNA binding agents.
true
true
true
true
true
7,357
5
DISCUSSION
1
43
[ "B43", "B44", "B19", "B45", "B46", "B10", "B47", "B10", "B48" ]
20,007,154
pmid-15274215|pmid-15911633|pmid-9547278|pmid-9380499|pmid-9685475|pmid-9862797|NA|pmid-9862797|pmid-10454596
Large molecules, such as echinomycin, may be more likely to be recognized by folded oligonucleotides.
[ "43", "44", "19", "45", "46", "10", "47", "10", "48" ]
101
42,472
0
false
Large molecules, such as echinomycin, may be more likely to be recognized by folded oligonucleotides.
[]
Large molecules, such as echinomycin, may be more likely to be recognized by folded oligonucleotides.
true
true
true
true
true
7,357
5
DISCUSSION
1
43
[ "B43", "B44", "B19", "B45", "B46", "B10", "B47", "B10", "B48" ]
20,007,154
pmid-15274215|pmid-15911633|pmid-9547278|pmid-9380499|pmid-9685475|pmid-9862797|NA|pmid-9862797|pmid-10454596
Work is in progress in order to explore all those possibilities.
[ "43", "44", "19", "45", "46", "10", "47", "10", "48" ]
64
42,473
0
false
Work is in progress in order to explore all those possibilities.
[]
Work is in progress in order to explore all those possibilities.
true
true
true
true
true
7,357
0
INTRODUCTION
1
1
[ "B1" ]
20,556,212
pmid-19154757|pmid-1589248|pmid-9187327
Pain following spinal cord injury (SCI) is a major challenge for patients coping with the physical and life-threatening consequences of SCI [1].
[ "1" ]
144
42,474
1
false
Pain following spinal cord injury (SCI) is a major challenge for patients coping with the physical and life-threatening consequences of SCI.
[ "1" ]
Pain following spinal cord injury (SCI) is a major challenge for patients coping with the physical and life-threatening consequences of SCI.
true
true
true
true
true
7,358
0
INTRODUCTION
1
1
[ "B1" ]
20,556,212
pmid-19154757|pmid-1589248|pmid-9187327
For the development of more effective treatments for pain of spinal origin, the pathophysiological and neurochemical changes following spinal injury should be clearly illustrated.
[ "1" ]
179
42,475
0
false
For the development of more effective treatments for pain of spinal origin, the pathophysiological and neurochemical changes following spinal injury should be clearly illustrated.
[]
For the development of more effective treatments for pain of spinal origin, the pathophysiological and neurochemical changes following spinal injury should be clearly illustrated.
true
true
true
true
true
7,358
1
INTRODUCTION
1
2
[ "B2", "B3", "B4", "B5", "B6", "B7", "B8", "B9" ]
20,556,212
pmid-1589248|pmid-18353556|pmid-11186233|pmid-12460606|pmid-1977091|pmid-1884213|pmid-9539683|pmid-15530884|pmid-19154757|pmid-1361523|pmid-1697342|pmid-9539683
An important consideration in the study of injury-induced spinal pain using an animal model is the pathological and/or behavioral responses associated with human SCI.
[ "2", "3", "4", "5", "6", "7", "8", "9" ]
166
42,476
0
false
An important consideration in the study of injury-induced spinal pain using an animal model is the pathological and/or behavioral responses associated with human SCI.
[]
An important consideration in the study of injury-induced spinal pain using an animal model is the pathological and/or behavioral responses associated with human SCI.
true
true
true
true
true
7,359
1
INTRODUCTION
1
2
[ "B2", "B3", "B4", "B5", "B6", "B7", "B8", "B9" ]
20,556,212
pmid-1589248|pmid-18353556|pmid-11186233|pmid-12460606|pmid-1977091|pmid-1884213|pmid-9539683|pmid-15530884|pmid-19154757|pmid-1361523|pmid-1697342|pmid-9539683
Numerous experimental models, including photochemical [2], hemisection [3], contusion [4] and clip compression [5] models, have been developed to explicate the complex pathophysiological mechanisms of spinal cord injury.
[ "2", "3", "4", "5", "6", "7", "8", "9" ]
220
42,477
1
false
Numerous experimental models, including photochemical, hemisection, contusion and clip compression models, have been developed to explicate the complex pathophysiological mechanisms of spinal cord injury.
[ "2", "3", "4", "5" ]
Numerous experimental models, including photochemical, hemisection, contusion and clip compression models, have been developed to explicate the complex pathophysiological mechanisms of spinal cord injury.
true
true
true
true
true
7,359
1
INTRODUCTION
1
2
[ "B2", "B3", "B4", "B5", "B6", "B7", "B8", "B9" ]
20,556,212
pmid-1589248|pmid-18353556|pmid-11186233|pmid-12460606|pmid-1977091|pmid-1884213|pmid-9539683|pmid-15530884|pmid-19154757|pmid-1361523|pmid-1697342|pmid-9539683
Although these models share many pathological characteristics with the human condition, the specific neural substrates responsible for the injury-induced abnormal sensations are not yet elucidated.
[ "2", "3", "4", "5", "6", "7", "8", "9" ]
197
42,478
0
false
Although these models share many pathological characteristics with the human condition, the specific neural substrates responsible for the injury-induced abnormal sensations are not yet elucidated.
[]
Although these models share many pathological characteristics with the human condition, the specific neural substrates responsible for the injury-induced abnormal sensations are not yet elucidated.
true
true
true
true
true
7,359
1
INTRODUCTION
1
2
[ "B2", "B3", "B4", "B5", "B6", "B7", "B8", "B9" ]
20,556,212
pmid-1589248|pmid-18353556|pmid-11186233|pmid-12460606|pmid-1977091|pmid-1884213|pmid-9539683|pmid-15530884|pmid-19154757|pmid-1361523|pmid-1697342|pmid-9539683
Based on previous studies documenting the elevated excitatory amino acid levels commonly associated with spinal injury [6,7], Yezierski et al.
[ "2", "3", "4", "5", "6", "7", "8", "9" ]
142
42,479
0
false
Based on previous studies documenting the elevated excitatory amino acid levels commonly associated with spinal injury, Yezierski et al.
[ "6,7" ]
Based on previous studies documenting the elevated excitatory amino acid levels commonly associated with spinal injury, Yezierski et al.
true
true
true
true
true
7,359
1
INTRODUCTION
1
8
[ "B2", "B3", "B4", "B5", "B6", "B7", "B8", "B9" ]
20,556,212
pmid-1589248|pmid-18353556|pmid-11186233|pmid-12460606|pmid-1977091|pmid-1884213|pmid-9539683|pmid-15530884|pmid-19154757|pmid-1361523|pmid-1697342|pmid-9539683
[8] injected the AMPA-metabotropic receptor agonist quisqualic acid into the grey matter of the spinal cord in an effort to simulate injury-induced elevations of excitatory amino acids.
[ "2", "3", "4", "5", "6", "7", "8", "9" ]
185
42,480
1
false
injected the AMPA-metabotropic receptor agonist quisqualic acid into the grey matter of the spinal cord in an effort to simulate injury-induced elevations of excitatory amino acids.
[ "8" ]
injected the AMPA-metabotropic receptor agonist quisqualic acid into the grey matter of the spinal cord in an effort to simulate injury-induced elevations of excitatory amino acids.
false
true
true
true
false
7,359
1
INTRODUCTION
1
2
[ "B2", "B3", "B4", "B5", "B6", "B7", "B8", "B9" ]
20,556,212
pmid-1589248|pmid-18353556|pmid-11186233|pmid-12460606|pmid-1977091|pmid-1884213|pmid-9539683|pmid-15530884|pmid-19154757|pmid-1361523|pmid-1697342|pmid-9539683
They reported that intraspinal injections of the AMPA-metabotropic receptor agonist quisqualic acid induce the progressive pathological sequela resembling the cascade of events described following ischemic and traumatic SCI, and that the morphological changes of the spinal cord following intraspinal injection correlate...
[ "2", "3", "4", "5", "6", "7", "8", "9" ]
414
42,481
0
false
They reported that intraspinal injections of the AMPA-metabotropic receptor agonist quisqualic acid induce the progressive pathological sequela resembling the cascade of events described following ischemic and traumatic SCI, and that the morphological changes of the spinal cord following intraspinal injection correlate...
[]
They reported that intraspinal injections of the AMPA-metabotropic receptor agonist quisqualic acid induce the progressive pathological sequela resembling the cascade of events described following ischemic and traumatic SCI, and that the morphological changes of the spinal cord following intraspinal injection correlate...
true
true
true
true
true
7,359
1
INTRODUCTION
1
9
[ "B2", "B3", "B4", "B5", "B6", "B7", "B8", "B9" ]
20,556,212
pmid-1589248|pmid-18353556|pmid-11186233|pmid-12460606|pmid-1977091|pmid-1884213|pmid-9539683|pmid-15530884|pmid-19154757|pmid-1361523|pmid-1697342|pmid-9539683
Moreover, it has also been demonstrated that the injection of N-methyl-D-aspartate (NMDA) into the ventral horn of the spinal cord induces intense neuronal degeneration and acute inflammation in both the grey and white matter [9].
[ "2", "3", "4", "5", "6", "7", "8", "9" ]
230
42,482
1
false
Moreover, it has also been demonstrated that the injection of N-methyl-D-aspartate (NMDA) into the ventral horn of the spinal cord induces intense neuronal degeneration and acute inflammation in both the grey and white matter.
[ "9" ]
Moreover, it has also been demonstrated that the injection of N-methyl-D-aspartate (NMDA) into the ventral horn of the spinal cord induces intense neuronal degeneration and acute inflammation in both the grey and white matter.
true
true
true
true
true
7,359
2
INTRODUCTION
0
null
null
20,556,212
pmid-11844532|pmid-15530884|pmid-12125741
The present study was designed to evaluate the morphological changes of the dorsal horn of the spinal cord and profiles of pain behaviors following intraspinal injection of NMDA in rats.
null
186
42,483
0
false
null
null
The present study was designed to evaluate the morphological changes of the dorsal horn of the spinal cord and profiles of pain behaviors following intraspinal injection of NMDA in rats.
true
true
true
true
true
7,360
0
DISCUSSION
1
2
[ "B2", "B11" ]
20,556,212
pmid-19154757|pmid-1589248|pmid-9187327
The purpose of this study was to evaluate the morphological changes of the dorsal horn of the spinal cord and profiles of pain behaviors following intraspinal injection of NMDA in rats.
[ "2", "11" ]
185
42,484
0
false
The purpose of this study was to evaluate the morphological changes of the dorsal horn of the spinal cord and profiles of pain behaviors following intraspinal injection of NMDA in rats.
[]
The purpose of this study was to evaluate the morphological changes of the dorsal horn of the spinal cord and profiles of pain behaviors following intraspinal injection of NMDA in rats.
true
true
true
true
true
7,361
0
DISCUSSION
1
2
[ "B2", "B11" ]
20,556,212
pmid-19154757|pmid-1589248|pmid-9187327
A major finding of the present study is that intrarspinal injection of NMDA induced excessive grooming behaviors and intense neuronal degeneration in the ipsilateral dorsal horn of the spinal cord.
[ "2", "11" ]
197
42,485
0
false
A major finding of the present study is that intrarspinal injection of NMDA induced excessive grooming behaviors and intense neuronal degeneration in the ipsilateral dorsal horn of the spinal cord.
[]
A major finding of the present study is that intrarspinal injection of NMDA induced excessive grooming behaviors and intense neuronal degeneration in the ipsilateral dorsal horn of the spinal cord.
true
true
true
true
true
7,361
0
DISCUSSION
1
2
[ "B2", "B11" ]
20,556,212
pmid-19154757|pmid-1589248|pmid-9187327
The histopathological findings were similar to those previously reported quisqualic acid-induced excitotoxic damage to the spinal cord [2,11].
[ "2", "11" ]
142
42,486
0
false
The histopathological findings were similar to those previously reported quisqualic acid-induced excitotoxic damage to the spinal cord.
[ "2,11" ]
The histopathological findings were similar to those previously reported quisqualic acid-induced excitotoxic damage to the spinal cord.
true
true
true
true
true
7,361
0
DISCUSSION
1
2
[ "B2", "B11" ]
20,556,212
pmid-19154757|pmid-1589248|pmid-9187327
Although the incidence of mechanical and cold allodynia following intraspinal injection was low, excessive grooming behavior commonly seen in animals suffering from experimental central neuropathic pain was evident, especially in the 100 mM NMDA group.
[ "2", "11" ]
252
42,487
0
false
Although the incidence of mechanical and cold allodynia following intraspinal injection was low, excessive grooming behavior commonly seen in animals suffering from experimental central neuropathic pain was evident, especially in the 100 mM NMDA group.
[]
Although the incidence of mechanical and cold allodynia following intraspinal injection was low, excessive grooming behavior commonly seen in animals suffering from experimental central neuropathic pain was evident, especially in the 100 mM NMDA group.
true
true
true
true
true
7,361
0
DISCUSSION
1
2
[ "B2", "B11" ]
20,556,212
pmid-19154757|pmid-1589248|pmid-9187327
On the spinal cord sections of the 100 mM NMDA group prepared after four-week survival periods, dilation of the central canal and formation of intraspinal cavities were observed.
[ "2", "11" ]
178
42,488
0
false
On the spinal cord sections of the 100 mM NMDA group prepared after four-week survival periods, dilation of the central canal and formation of intraspinal cavities were observed.
[]
On the spinal cord sections of the 100 mM NMDA group prepared after four-week survival periods, dilation of the central canal and formation of intraspinal cavities were observed.
true
true
true
true
true
7,361
0
DISCUSSION
1
2
[ "B2", "B11" ]
20,556,212
pmid-19154757|pmid-1589248|pmid-9187327
Intraspinal NMDA-induced neuronal loss occurred mainly at the lamina III-V.
[ "2", "11" ]
75
42,489
0
false
Intraspinal NMDA-induced neuronal loss occurred mainly at the lamina III-V.
[]
Intraspinal NMDA-induced neuronal loss occurred mainly at the lamina III-V.
true
true
true
true
true
7,361
0
DISCUSSION
1
2
[ "B2", "B11" ]
20,556,212
pmid-19154757|pmid-1589248|pmid-9187327
The present data suggest the existence of a causal relationship between the neuronal loss of the dorsal horn and the evoked/spontaneous pain-like behavior.
[ "2", "11" ]
155
42,490
0
false
The present data suggest the existence of a causal relationship between the neuronal loss of the dorsal horn and the evoked/spontaneous pain-like behavior.
[]
The present data suggest the existence of a causal relationship between the neuronal loss of the dorsal horn and the evoked/spontaneous pain-like behavior.
true
true
true
true
true
7,361
1
DISCUSSION
1
12
[ "B12", "B13", "B14", "B8" ]
20,556,212
pmid-1589248|pmid-18353556|pmid-11186233|pmid-12460606|pmid-1977091|pmid-1884213|pmid-9539683|pmid-15530884|pmid-19154757|pmid-1361523|pmid-1697342|pmid-9539683
Concentrated excitatory amino acids following trauma or ischemia can lead to a prolonged period of depolarization and the initiation of a cellular cascade that ultimately results in neuronal death.
[ "12", "13", "14", "8" ]
197
42,491
0
false
Concentrated excitatory amino acids following trauma or ischemia can lead to a prolonged period of depolarization and the initiation of a cellular cascade that ultimately results in neuronal death.
[]
Concentrated excitatory amino acids following trauma or ischemia can lead to a prolonged period of depolarization and the initiation of a cellular cascade that ultimately results in neuronal death.
true
true
true
true
true
7,362
1
DISCUSSION
1
12
[ "B12", "B13", "B14", "B8" ]
20,556,212
pmid-1589248|pmid-18353556|pmid-11186233|pmid-12460606|pmid-1977091|pmid-1884213|pmid-9539683|pmid-15530884|pmid-19154757|pmid-1361523|pmid-1697342|pmid-9539683
Both NMDA and non-NMDA receptors contribute to the excitotoxic effects of elevated glutamate levels in the spinal cord [12].
[ "12", "13", "14", "8" ]
124
42,492
1
false
Both NMDA and non-NMDA receptors contribute to the excitotoxic effects of elevated glutamate levels in the spinal cord.
[ "12" ]
Both NMDA and non-NMDA receptors contribute to the excitotoxic effects of elevated glutamate levels in the spinal cord.
true
true
true
true
true
7,362
1
DISCUSSION
1
13
[ "B12", "B13", "B14", "B8" ]
20,556,212
pmid-1589248|pmid-18353556|pmid-11186233|pmid-12460606|pmid-1977091|pmid-1884213|pmid-9539683|pmid-15530884|pmid-19154757|pmid-1361523|pmid-1697342|pmid-9539683
Several classes of excitatory amino acid receptors are thought to be involved in glutamate excitotoxicity, including NMDA, AMPA, kainate and metabotropic receptors [13].
[ "12", "13", "14", "8" ]
169
42,493
1
false
Several classes of excitatory amino acid receptors are thought to be involved in glutamate excitotoxicity, including NMDA, AMPA, kainate and metabotropic receptors.
[ "13" ]
Several classes of excitatory amino acid receptors are thought to be involved in glutamate excitotoxicity, including NMDA, AMPA, kainate and metabotropic receptors.
true
true
true
true
true
7,362
1
DISCUSSION
1
14
[ "B12", "B13", "B14", "B8" ]
20,556,212
pmid-1589248|pmid-18353556|pmid-11186233|pmid-12460606|pmid-1977091|pmid-1884213|pmid-9539683|pmid-15530884|pmid-19154757|pmid-1361523|pmid-1697342|pmid-9539683
Ionotropic receptors regulate the opening of voltage-gated ion channels, and metabotropic receptors are linked via G-proteins to phospholipase C. Glutamate-induced cell death that results from NMDA ionotropic receptor activation is well documented as largely due to the excessive influx of sodium and calcium ions [14].
[ "12", "13", "14", "8" ]
319
42,494
1
false
Ionotropic receptors regulate the opening of voltage-gated ion channels, and metabotropic receptors are linked via G-proteins to phospholipase C. Glutamate-induced cell death that results from NMDA ionotropic receptor activation is well documented as largely due to the excessive influx of sodium and calcium ions.
[ "14" ]
Ionotropic receptors regulate the opening of voltage-gated ion channels, and metabotropic receptors are linked via G-proteins to phospholipase C. Glutamate-induced cell death that results from NMDA ionotropic receptor activation is well documented as largely due to the excessive influx of sodium and calcium ions.
true
true
true
true
true
7,362
1
DISCUSSION
1
12
[ "B12", "B13", "B14", "B8" ]
20,556,212
pmid-1589248|pmid-18353556|pmid-11186233|pmid-12460606|pmid-1977091|pmid-1884213|pmid-9539683|pmid-15530884|pmid-19154757|pmid-1361523|pmid-1697342|pmid-9539683
The role of non-NMDA receptors in the injury of spinal neurons has been studied with a simulated excitotoxic spinal cord injury model using intraspinal quisqualic acid injection.
[ "12", "13", "14", "8" ]
178
42,495
0
false
The role of non-NMDA receptors in the injury of spinal neurons has been studied with a simulated excitotoxic spinal cord injury model using intraspinal quisqualic acid injection.
[]
The role of non-NMDA receptors in the injury of spinal neurons has been studied with a simulated excitotoxic spinal cord injury model using intraspinal quisqualic acid injection.
true
true
true
true
true
7,362
1
DISCUSSION
1
8
[ "B12", "B13", "B14", "B8" ]
20,556,212
pmid-1589248|pmid-18353556|pmid-11186233|pmid-12460606|pmid-1977091|pmid-1884213|pmid-9539683|pmid-15530884|pmid-19154757|pmid-1361523|pmid-1697342|pmid-9539683
The results suggest that the specific non-NMDA receptor agonist AMPA produces histological changes similar to those observed following quisqualic acid injections [8].
[ "12", "13", "14", "8" ]
166
42,496
1
false
The results suggest that the specific non-NMDA receptor agonist AMPA produces histological changes similar to those observed following quisqualic acid injections.
[ "8" ]
The results suggest that the specific non-NMDA receptor agonist AMPA produces histological changes similar to those observed following quisqualic acid injections.
true
true
true
true
true
7,362
2
DISCUSSION
1
15
[ "B15", "B9", "B16" ]
20,556,212
pmid-11844532|pmid-15530884|pmid-12125741
NMDA receptors are present on the endothelial cells of grey matter vasculature and damage to blood vessels in the grey matter can induce damage to the adjacent white matter [15].
[ "15", "9", "16" ]
178
42,497
1
false
NMDA receptors are present on the endothelial cells of grey matter vasculature and damage to blood vessels in the grey matter can induce damage to the adjacent white matter.
[ "15" ]
NMDA receptors are present on the endothelial cells of grey matter vasculature and damage to blood vessels in the grey matter can induce damage to the adjacent white matter.
true
true
true
true
true
7,363
2
DISCUSSION
1
15
[ "B15", "B9", "B16" ]
20,556,212
pmid-11844532|pmid-15530884|pmid-12125741
NMDA molecules can bind to receptors in the endothelial cells, inducing blood-brain barrier breakdown, acute inflammation and tissue damage.
[ "15", "9", "16" ]
140
42,498
0
false
NMDA molecules can bind to receptors in the endothelial cells, inducing blood-brain barrier breakdown, acute inflammation and tissue damage.
[]
NMDA molecules can bind to receptors in the endothelial cells, inducing blood-brain barrier breakdown, acute inflammation and tissue damage.
true
true
true
true
true
7,363
2
DISCUSSION
1
9
[ "B15", "B9", "B16" ]
20,556,212
pmid-11844532|pmid-15530884|pmid-12125741
The expansion of the primary necrotic area is a secondary pathological phenomenon involving a multitude of mechanisms, including pathological release of excitatory amino acids, free radical formation, nitric oxide synthesis, and inflammation [9].
[ "15", "9", "16" ]
246
42,499
1
false
The expansion of the primary necrotic area is a secondary pathological phenomenon involving a multitude of mechanisms, including pathological release of excitatory amino acids, free radical formation, nitric oxide synthesis, and inflammation.
[ "9" ]
The expansion of the primary necrotic area is a secondary pathological phenomenon involving a multitude of mechanisms, including pathological release of excitatory amino acids, free radical formation, nitric oxide synthesis, and inflammation.
true
true
true
true
true
7,363
2
DISCUSSION
1
16
[ "B15", "B9", "B16" ]
20,556,212
pmid-11844532|pmid-15530884|pmid-12125741
Neuronal degeneration and activated macrophages/microglia in the grey matter could also release cytokines and other diffusible factors, such as nitric oxide, which can induce damage to white matter or potentiate deleterious tissue damage by pathological activation of non-NMDA receptors [16].
[ "15", "9", "16" ]
292
42,500
1
false
Neuronal degeneration and activated macrophages/microglia in the grey matter could also release cytokines and other diffusible factors, such as nitric oxide, which can induce damage to white matter or potentiate deleterious tissue damage by pathological activation of non-NMDA receptors.
[ "16" ]
Neuronal degeneration and activated macrophages/microglia in the grey matter could also release cytokines and other diffusible factors, such as nitric oxide, which can induce damage to white matter or potentiate deleterious tissue damage by pathological activation of non-NMDA receptors.
true
true
true
true
true
7,363
3
DISCUSSION
1
17
[ "B17", "B1", "B17", "B18" ]
20,556,212
pmid-15135936|pmid-19154757|pmid-15135936|pmid-18619906
In the present study, excessive grooming behavior correlated with a lesion sparing the superficial laminae (lamina I-II, superficial in Fig.
[ "17", "1", "17", "18" ]
140
42,501
0
false
In the present study, excessive grooming behavior correlated with a lesion sparing the superficial laminae (lamina I-II, superficial in Fig.
[]
In the present study, excessive grooming behavior correlated with a lesion sparing the superficial laminae (lamina I-II, superficial in Fig.
true
true
true
true
true
7,364
3
DISCUSSION
1
17
[ "B17", "B1", "B17", "B18" ]
20,556,212
pmid-15135936|pmid-19154757|pmid-15135936|pmid-18619906
3) and neuronal damage in the neck of the dorsal horn (lamina III-IV, neck in Fig.
[ "17", "1", "17", "18" ]
82
42,502
0
false
3) and neuronal damage in the neck of the dorsal horn (lamina III-IV, neck in Fig.
[]
3) and neuronal damage in the neck of the dorsal horn (lamina III-IV, neck in Fig.
false
false
true
true
false
7,364
3
DISCUSSION
1
17
[ "B17", "B1", "B17", "B18" ]
20,556,212
pmid-15135936|pmid-19154757|pmid-15135936|pmid-18619906
These results are consistent with those of the previous study, documenting that destruction of lamina I cells can prevent or eliminate excessive grooming behavior
[ "17", "1", "17", "18" ]
162
42,503
0
false
These results are consistent with those of the previous study, documenting that destruction of lamina I cells can prevent or eliminate excessive grooming behavior
[]
These results are consistent with those of the previous study, documenting that destruction of lamina I cells can prevent or eliminate excessive grooming behavior
true
true
false
true
false
7,364
3
DISCUSSION
1
17
[ "B17", "B1", "B17", "B18" ]
20,556,212
pmid-15135936|pmid-19154757|pmid-15135936|pmid-18619906
Pain associated with spinal cord injury can be divided into nociceptive (including musculoskeletal and visceral) and neuropathic (including above-, at- and below-level)
[ "17", "1", "17", "18" ]
168
42,504
0
false
Pain associated with spinal cord injury can be divided into nociceptive (including musculoskeletal and visceral) and neuropathic (including above-, at- and below-level)
[]
Pain associated with spinal cord injury can be divided into nociceptive (including musculoskeletal and visceral) and neuropathic (including above-, at- and below-level)
true
true
false
true
false
7,364
3
DISCUSSION
1
17
[ "B17", "B1", "B17", "B18" ]
20,556,212
pmid-15135936|pmid-19154757|pmid-15135936|pmid-18619906
The primary characteristic of at-level pain is a hypersensitive band of skin in dermatomes associated with spinal segments adjacent to the site of injury.
[ "17", "1", "17", "18" ]
154
42,505
0
false
The primary characteristic of at-level pain is a hypersensitive band of skin in dermatomes associated with spinal segments adjacent to the site of injury.
[]
The primary characteristic of at-level pain is a hypersensitive band of skin in dermatomes associated with spinal segments adjacent to the site of injury.
true
true
true
true
true
7,364
3
DISCUSSION
1
17
[ "B17", "B1", "B17", "B18" ]
20,556,212
pmid-15135936|pmid-19154757|pmid-15135936|pmid-18619906
Injury-induced loss of intrinsic inhibitory control and changes in the functional state of neurons adjacent to the site of injury represent the current view of a mechanism responsible for this condition [17].
[ "17", "1", "17", "18" ]
208
42,506
1
false
Injury-induced loss of intrinsic inhibitory control and changes in the functional state of neurons adjacent to the site of injury represent the current view of a mechanism responsible for this condition.
[ "17" ]
Injury-induced loss of intrinsic inhibitory control and changes in the functional state of neurons adjacent to the site of injury represent the current view of a mechanism responsible for this condition.
true
true
true
true
true
7,364
3
DISCUSSION
1
17
[ "B17", "B1", "B17", "B18" ]
20,556,212
pmid-15135936|pmid-19154757|pmid-15135936|pmid-18619906
Consistent with the clinical profile of at-level pain, hypersensitivity to thermal and mechanical stimuli are characteristics of the area targeted for excessive grooming behavior.
[ "17", "1", "17", "18" ]
179
42,507
0
false
Consistent with the clinical profile of at-level pain, hypersensitivity to thermal and mechanical stimuli are characteristics of the area targeted for excessive grooming behavior.
[]
Consistent with the clinical profile of at-level pain, hypersensitivity to thermal and mechanical stimuli are characteristics of the area targeted for excessive grooming behavior.
true
true
true
true
true
7,364
3
DISCUSSION
1
17
[ "B17", "B1", "B17", "B18" ]
20,556,212
pmid-15135936|pmid-19154757|pmid-15135936|pmid-18619906
Pain can be present in NMDA-injected animals without excessive grooming behavior, as evidenced by the finding that a few of the injected animals developed cold and mechanical allodynia below the level of injury without any signs of excessive grooming.
[ "17", "1", "17", "18" ]
251
42,508
0
false
Pain can be present in NMDA-injected animals without excessive grooming behavior, as evidenced by the finding that a few of the injected animals developed cold and mechanical allodynia below the level of injury without any signs of excessive grooming.
[]
Pain can be present in NMDA-injected animals without excessive grooming behavior, as evidenced by the finding that a few of the injected animals developed cold and mechanical allodynia below the level of injury without any signs of excessive grooming.
true
true
true
true
true
7,364
3
DISCUSSION
1
17
[ "B17", "B1", "B17", "B18" ]
20,556,212
pmid-15135936|pmid-19154757|pmid-15135936|pmid-18619906
In this study, efforts to correlate the pattern of neuronal loss with the development of hypersensitivity to cold and mechanical stimuli proved unsuccessful.
[ "17", "1", "17", "18" ]
157
42,509
0
false
In this study, efforts to correlate the pattern of neuronal loss with the development of hypersensitivity to cold and mechanical stimuli proved unsuccessful.
[]
In this study, efforts to correlate the pattern of neuronal loss with the development of hypersensitivity to cold and mechanical stimuli proved unsuccessful.
true
true
true
true
true
7,364
3
DISCUSSION
1
18
[ "B17", "B1", "B17", "B18" ]
20,556,212
pmid-15135936|pmid-19154757|pmid-15135936|pmid-18619906
It can be postulated that cold and mechanical allodynia were not developed due to somatosensory dysfunction associated with NMDA-induced injury to the white matter and death of the entire primary afferent neuron as a consequence of the central nervous system lesion [18].
[ "17", "1", "17", "18" ]
271
42,510
1
false
It can be postulated that cold and mechanical allodynia were not developed due to somatosensory dysfunction associated with NMDA-induced injury to the white matter and death of the entire primary afferent neuron as a consequence of the central nervous system lesion.
[ "18" ]
It can be postulated that cold and mechanical allodynia were not developed due to somatosensory dysfunction associated with NMDA-induced injury to the white matter and death of the entire primary afferent neuron as a consequence of the central nervous system lesion.
true
true
true
true
true
7,364
4
DISCUSSION
0
null
null
20,556,212
null
In conclusion, intraspinal injection of NMDA leads to the pathological sequela in the spinal cord and to excessive grooming behavior.
null
133
42,511
0
false
null
null
In conclusion, intraspinal injection of NMDA leads to the pathological sequela in the spinal cord and to excessive grooming behavior.
true
true
true
true
true
7,365
4
DISCUSSION
0
null
null
20,556,212
null
The morphological changes of the spinal cord resemble the cascade of events described following ischemic and traumatic SCI.
null
123
42,512
0
false
null
null
The morphological changes of the spinal cord resemble the cascade of events described following ischemic and traumatic SCI.
true
true
true
true
true
7,365
4
DISCUSSION
0
null
null
20,556,212
null
Excessive grooming behavior was associated with neuronal damage in the neck of the spinal dorsal horn and with sparing the superficial laminae.
null
143
42,513
0
false
null
null
Excessive grooming behavior was associated with neuronal damage in the neck of the spinal dorsal horn and with sparing the superficial laminae.
true
true
true
true
true
7,365
4
DISCUSSION
0
null
null
20,556,212
null
These results support the use of NMDA and excessive grooming behavior to study central neuropathic pain following SCI.
null
118
42,514
0
false
null
null
These results support the use of NMDA and excessive grooming behavior to study central neuropathic pain following SCI.
true
true
true
true
true
7,365
0
INTRODUCTION
1
1
[ "B1", "B2", "B1", "B3", "B4", "B5", "B6", "B6", "B7" ]
20,664,777
pmid-16514137|NA|pmid-16514137|pmid-15069304|pmid-16492908|pmid-8903474|pmid-11833360|pmid-11833360|pmid-11390274|pmid-8701470|pmid-8701470|pmid-4953930
Prostate cancer (CaP) has the highest incidence among cancers in the US and is the second leading cause of cancer-associated death in men [1].
[ "1", "2", "1", "3", "4", "5", "6", "6", "7" ]
142
42,515
1
false
Prostate cancer (CaP) has the highest incidence among cancers in the US and is the second leading cause of cancer-associated death in men.
[ "1" ]
Prostate cancer (CaP) has the highest incidence among cancers in the US and is the second leading cause of cancer-associated death in men.
true
true
true
true
true
7,366
0
INTRODUCTION
1
1
[ "B1", "B2", "B1", "B3", "B4", "B5", "B6", "B6", "B7" ]
20,664,777
pmid-16514137|NA|pmid-16514137|pmid-15069304|pmid-16492908|pmid-8903474|pmid-11833360|pmid-11833360|pmid-11390274|pmid-8701470|pmid-8701470|pmid-4953930
In Korea, its incidence is still increasing, compared to that of other cancers and it ranked fifth in incidence in 2005
[ "1", "2", "1", "3", "4", "5", "6", "6", "7" ]
119
42,516
0
false
In Korea, its incidence is still increasing, compared to that of other cancers and it ranked fifth in incidence in 2005
[]
In Korea, its incidence is still increasing, compared to that of other cancers and it ranked fifth in incidence in 2005
true
true
false
true
false
7,366
0
INTRODUCTION
1
1
[ "B1", "B2", "B1", "B3", "B4", "B5", "B6", "B6", "B7" ]
20,664,777
pmid-16514137|NA|pmid-16514137|pmid-15069304|pmid-16492908|pmid-8903474|pmid-11833360|pmid-11833360|pmid-11390274|pmid-8701470|pmid-8701470|pmid-4953930
Despite recent improvements in diagnosis and therapeutic techniques, the survival rate of CaP patients is poor because of the recurrence of the disease [1,3].
[ "1", "2", "1", "3", "4", "5", "6", "6", "7" ]
158
42,517
0
false
Despite recent improvements in diagnosis and therapeutic techniques, the survival rate of CaP patients is poor because of the recurrence of the disease.
[ "1,3" ]
Despite recent improvements in diagnosis and therapeutic techniques, the survival rate of CaP patients is poor because of the recurrence of the disease.
true
true
true
true
true
7,366
0
INTRODUCTION
1
1
[ "B1", "B2", "B1", "B3", "B4", "B5", "B6", "B6", "B7" ]
20,664,777
pmid-16514137|NA|pmid-16514137|pmid-15069304|pmid-16492908|pmid-8903474|pmid-11833360|pmid-11833360|pmid-11390274|pmid-8701470|pmid-8701470|pmid-4953930
The lack of effective therapies for advanced CaP is related to a large extent to poor understanding of the molecular mechanisms underlying the progression of this disease (invasion and metastasis)
[ "1", "2", "1", "3", "4", "5", "6", "6", "7" ]
196
42,518
0
false
The lack of effective therapies for advanced CaP is related to a large extent to poor understanding of the molecular mechanisms underlying the progression of this disease (invasion and metastasis)
[]
The lack of effective therapies for advanced CaP is related to a large extent to poor understanding of the molecular mechanisms underlying the progression of this disease (invasion and metastasis)
true
true
false
true
false
7,366