Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
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3
INTRODUCTION
1
27
[ "B11 B12 B13 B14 B15 B16", "B17", "B18", "B19", "B20", "B21", "B22", "B19", "B23", "B24", "B25", "B26", "B27" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
PML-NBs are subnuclear domains which critically depend on the presence of the PML tumor suppressor protein and exert a variety of biological functions ranging from control of apoptosis to hematopoietic differentiation and gene transcription (27).
[ "11–16", "17", "18", "19", "20", "21", "22", "19", "23", "24", "25", "26", "27" ]
246
43,019
1
false
PML-NBs are subnuclear domains which critically depend on the presence of the PML tumor suppressor protein and exert a variety of biological functions ranging from control of apoptosis to hematopoietic differentiation and gene transcription.
[ "27" ]
PML-NBs are subnuclear domains which critically depend on the presence of the PML tumor suppressor protein and exert a variety of biological functions ranging from control of apoptosis to hematopoietic differentiation and gene transcription.
true
true
true
true
true
7,454
4
INTRODUCTION
1
28
[ "B28", "B29", "B30", "B31", "B32", "B28", "B33", "B33" ]
20,507,904
pmid-16840782|pmid-15128824|pmid-17574024|pmid-19595715|pmid-19737522|pmid-16840782|pmid-17574021|pmid-17574021
Among the kinases that phosphorylate serine 468 and 536 is IKKε (also called IKKi), a non-canonical IKK (28,29).
[ "28", "29", "30", "31", "32", "28", "33", "33" ]
112
43,020
0
false
Among the kinases that phosphorylate serine 468 and 536 is IKKε (also called IKKi), a non-canonical IKK.
[ "28,29" ]
Among the kinases that phosphorylate serine 468 and 536 is IKKε (also called IKKi), a non-canonical IKK.
true
true
true
true
true
7,455
4
INTRODUCTION
1
30
[ "B28", "B29", "B30", "B31", "B32", "B28", "B33", "B33" ]
20,507,904
pmid-16840782|pmid-15128824|pmid-17574024|pmid-19595715|pmid-19737522|pmid-16840782|pmid-17574021|pmid-17574021
IKKε is also an important mediator of the interferon response, as it phosphorylates the transcription factors IRF3 and IRF7, which form a complex with NF-κB to establish a multi-protein enhanceosome mediating the production of type I interferons (30).
[ "28", "29", "30", "31", "32", "28", "33", "33" ]
251
43,021
1
false
IKKε is also an important mediator of the interferon response, as it phosphorylates the transcription factors IRF3 and IRF7, which form a complex with NF-κB to establish a multi-protein enhanceosome mediating the production of type I interferons.
[ "30" ]
IKKε is also an important mediator of the interferon response, as it phosphorylates the transcription factors IRF3 and IRF7, which form a complex with NF-κB to establish a multi-protein enhanceosome mediating the production of type I interferons.
true
true
true
true
true
7,455
4
INTRODUCTION
1
28
[ "B28", "B29", "B30", "B31", "B32", "B28", "B33", "B33" ]
20,507,904
pmid-16840782|pmid-15128824|pmid-17574024|pmid-19595715|pmid-19737522|pmid-16840782|pmid-17574021|pmid-17574021
Recent evidence showed several additional functions for IKKε.
[ "28", "29", "30", "31", "32", "28", "33", "33" ]
61
43,022
0
false
Recent evidence showed several additional functions for IKKε.
[]
Recent evidence showed several additional functions for IKKε.
true
true
true
true
true
7,455
4
INTRODUCTION
1
31
[ "B28", "B29", "B30", "B31", "B32", "B28", "B33", "B33" ]
20,507,904
pmid-16840782|pmid-15128824|pmid-17574024|pmid-19595715|pmid-19737522|pmid-16840782|pmid-17574021|pmid-17574021
The kinase also participates in the clearance of the nuclear receptor corepressor (NCoR) from distinct promoters (31).
[ "28", "29", "30", "31", "32", "28", "33", "33" ]
118
43,023
1
false
The kinase also participates in the clearance of the nuclear receptor corepressor (NCoR) from distinct promoters.
[ "31" ]
The kinase also participates in the clearance of the nuclear receptor corepressor (NCoR) from distinct promoters.
true
true
true
true
true
7,455
4
INTRODUCTION
1
32
[ "B28", "B29", "B30", "B31", "B32", "B28", "B33", "B33" ]
20,507,904
pmid-16840782|pmid-15128824|pmid-17574024|pmid-19595715|pmid-19737522|pmid-16840782|pmid-17574021|pmid-17574021
Mouse models also revealed the importance of IKKε for low-grade chronic inflammation as it occurs in obesity (32).
[ "28", "29", "30", "31", "32", "28", "33", "33" ]
114
43,024
1
false
Mouse models also revealed the importance of IKKε for low-grade chronic inflammation as it occurs in obesity.
[ "32" ]
Mouse models also revealed the importance of IKKε for low-grade chronic inflammation as it occurs in obesity.
true
true
true
true
true
7,455
4
INTRODUCTION
1
28
[ "B28", "B29", "B30", "B31", "B32", "B28", "B33", "B33" ]
20,507,904
pmid-16840782|pmid-15128824|pmid-17574024|pmid-19595715|pmid-19737522|pmid-16840782|pmid-17574021|pmid-17574021
Integrative genomic approaches identified IKKε as a breast cancer oncogene amplified and overexpressed in >30% of breast tumors and derived cell lines (28,33).
[ "28", "29", "30", "31", "32", "28", "33", "33" ]
159
43,025
0
false
Integrative genomic approaches identified IKKε as a breast cancer oncogene amplified and overexpressed in >30% of breast tumors and derived cell lines.
[ "28,33" ]
Integrative genomic approaches identified IKKε as a breast cancer oncogene amplified and overexpressed in >30% of breast tumors and derived cell lines.
true
true
true
true
true
7,455
4
INTRODUCTION
1
33
[ "B28", "B29", "B30", "B31", "B32", "B28", "B33", "B33" ]
20,507,904
pmid-16840782|pmid-15128824|pmid-17574024|pmid-19595715|pmid-19737522|pmid-16840782|pmid-17574021|pmid-17574021
Overexpression of IKKε is sufficient to transform cells, whereas siRNA-mediated knockdown of the kinase decreases the survival of breast cancer cells (33).
[ "28", "29", "30", "31", "32", "28", "33", "33" ]
155
43,026
1
false
Overexpression of IKKε is sufficient to transform cells, whereas siRNA-mediated knockdown of the kinase decreases the survival of breast cancer cells.
[ "33" ]
Overexpression of IKKε is sufficient to transform cells, whereas siRNA-mediated knockdown of the kinase decreases the survival of breast cancer cells.
true
true
true
true
true
7,455
5
INTRODUCTION
0
null
null
20,507,904
null
Here we have investigated the physiological role of regulatory p65 phosphorylation by reconstitution experiments.
null
113
43,027
0
false
null
null
Here we have investigated the physiological role of regulatory p65 phosphorylation by reconstitution experiments.
true
true
true
true
true
7,456
5
INTRODUCTION
0
null
null
20,507,904
null
The impact of p65 phosphorylation on gene expression was highly gene specific and accordingly p65 phosphorylation at serine 468 and 536 occurred at distinct intracellular locations.
null
181
43,028
0
false
null
null
The impact of p65 phosphorylation on gene expression was highly gene specific and accordingly p65 phosphorylation at serine 468 and 536 occurred at distinct intracellular locations.
true
true
true
true
true
7,456
5
INTRODUCTION
0
null
null
20,507,904
null
TNF stimulation resulted in the inducible association of IKKε to p65 and the p65-dependent transport of the kinase to the nucleus and PML-NBs.
null
142
43,029
0
false
null
null
TNF stimulation resulted in the inducible association of IKKε to p65 and the p65-dependent transport of the kinase to the nucleus and PML-NBs.
true
true
true
true
true
7,456
5
INTRODUCTION
0
null
null
20,507,904
null
IKKε was required for the expression of specific genes and ChIP experiments revealed the recruitment of IKKε to the control regions of many inflammatory target genes, thus identifying a novel role for IKKε in the nucleus.
null
221
43,030
0
false
null
null
IKKε was required for the expression of specific genes and ChIP experiments revealed the recruitment of IKKε to the control regions of many inflammatory target genes, thus identifying a novel role for IKKε in the nucleus.
true
true
true
true
true
7,456
0
DISCUSSION
1
29
[ "B29", "B9", "B10" ]
20,507,904
pmid-19483709|pmid-19302050|pmid-16485027|pmid-18267068|pmid-17047224|pmid-15128824|pmid-17707233|pmid-14527995
This study suggests that the functional relevance of a phosphorylation site is also influenced by its intracellular distribution.
[ "29", "9", "10" ]
129
43,031
0
false
This study suggests that the functional relevance of a phosphorylation site is also influenced by its intracellular distribution.
[]
This study suggests that the functional relevance of a phosphorylation site is also influenced by its intracellular distribution.
true
true
true
true
true
7,457
0
DISCUSSION
1
29
[ "B29", "B9", "B10" ]
20,507,904
pmid-19483709|pmid-19302050|pmid-16485027|pmid-18267068|pmid-17047224|pmid-15128824|pmid-17707233|pmid-14527995
While the p65 protein is found in the entire nucleus except the nucleolus in TNF-stimulated cells, the phosphorylated p65 proteins accumulate in specific subcellular regions.
[ "29", "9", "10" ]
174
43,032
0
false
While the p65 protein is found in the entire nucleus except the nucleolus in TNF-stimulated cells, the phosphorylated p65 proteins accumulate in specific subcellular regions.
[]
While the p65 protein is found in the entire nucleus except the nucleolus in TNF-stimulated cells, the phosphorylated p65 proteins accumulate in specific subcellular regions.
true
true
true
true
true
7,457
0
DISCUSSION
1
29
[ "B29", "B9", "B10" ]
20,507,904
pmid-19483709|pmid-19302050|pmid-16485027|pmid-18267068|pmid-17047224|pmid-15128824|pmid-17707233|pmid-14527995
Immunofluorescence experiments showed a strong enrichment of serine 536 phosphorylated p65 in the area surrounding the nucleus.
[ "29", "9", "10" ]
127
43,033
0
false
Immunofluorescence experiments showed a strong enrichment of serine 536 phosphorylated p65 in the area surrounding the nucleus.
[]
Immunofluorescence experiments showed a strong enrichment of serine 536 phosphorylated p65 in the area surrounding the nucleus.
true
true
true
true
true
7,457
0
DISCUSSION
1
29
[ "B29", "B9", "B10" ]
20,507,904
pmid-19483709|pmid-19302050|pmid-16485027|pmid-18267068|pmid-17047224|pmid-15128824|pmid-17707233|pmid-14527995
This localization is compatible with published data suggesting a functional role of p65 serine 536 phosphorylation for controlling the kinetics of p65 nuclear import (29).
[ "29", "9", "10" ]
171
43,034
1
false
This localization is compatible with published data suggesting a functional role of p65 serine 536 phosphorylation for controlling the kinetics of p65 nuclear import.
[ "29" ]
This localization is compatible with published data suggesting a functional role of p65 serine 536 phosphorylation for controlling the kinetics of p65 nuclear import.
true
true
true
true
true
7,457
0
DISCUSSION
1
29
[ "B29", "B9", "B10" ]
20,507,904
pmid-19483709|pmid-19302050|pmid-16485027|pmid-18267068|pmid-17047224|pmid-15128824|pmid-17707233|pmid-14527995
In contrast, p65 serine 468 phosphorylation was predominantly nuclear and occurred in a speckled distribution which shows strong accumulation of serine 468 phosphorylated p65 in distinct nuclear regions.
[ "29", "9", "10" ]
203
43,035
0
false
In contrast, p65 serine 468 phosphorylation was predominantly nuclear and occurred in a speckled distribution which shows strong accumulation of serine 468 phosphorylated p65 in distinct nuclear regions.
[]
In contrast, p65 serine 468 phosphorylation was predominantly nuclear and occurred in a speckled distribution which shows strong accumulation of serine 468 phosphorylated p65 in distinct nuclear regions.
true
true
true
true
true
7,457
0
DISCUSSION
1
29
[ "B29", "B9", "B10" ]
20,507,904
pmid-19483709|pmid-19302050|pmid-16485027|pmid-18267068|pmid-17047224|pmid-15128824|pmid-17707233|pmid-14527995
As several groups of NF-κB target genes are not randomly distributed in the genome and are enriched in distinct chromosomal clusters (9,10), it will be relevant to investigate whether these genomic regions are selectively enriched with phosphorylated p65.
[ "29", "9", "10" ]
255
43,036
0
false
As several groups of NF-κB target genes are not randomly distributed in the genome and are enriched in distinct chromosomal clusters, it will be relevant to investigate whether these genomic regions are selectively enriched with phosphorylated p65.
[ "9,10" ]
As several groups of NF-κB target genes are not randomly distributed in the genome and are enriched in distinct chromosomal clusters, it will be relevant to investigate whether these genomic regions are selectively enriched with phosphorylated p65.
true
true
true
true
true
7,457
0
DISCUSSION
1
29
[ "B29", "B9", "B10" ]
20,507,904
pmid-19483709|pmid-19302050|pmid-16485027|pmid-18267068|pmid-17047224|pmid-15128824|pmid-17707233|pmid-14527995
Our data show that the effects of p65 phosphorylation depend on the individual target gene, an observation which is supported by the microscopical data which revealed focal points of p65 phosphorylation in the nucleus.
[ "29", "9", "10" ]
218
43,037
0
false
Our data show that the effects of p65 phosphorylation depend on the individual target gene, an observation which is supported by the microscopical data which revealed focal points of p65 phosphorylation in the nucleus.
[]
Our data show that the effects of p65 phosphorylation depend on the individual target gene, an observation which is supported by the microscopical data which revealed focal points of p65 phosphorylation in the nucleus.
true
true
true
true
true
7,457
0
DISCUSSION
1
29
[ "B29", "B9", "B10" ]
20,507,904
pmid-19483709|pmid-19302050|pmid-16485027|pmid-18267068|pmid-17047224|pmid-15128824|pmid-17707233|pmid-14527995
The accumulation of phosphorylated p65 in distinct regions raises the question for the molecular mechanisms underlying this inhomogeneous distribution.
[ "29", "9", "10" ]
151
43,038
0
false
The accumulation of phosphorylated p65 in distinct regions raises the question for the molecular mechanisms underlying this inhomogeneous distribution.
[]
The accumulation of phosphorylated p65 in distinct regions raises the question for the molecular mechanisms underlying this inhomogeneous distribution.
true
true
true
true
true
7,457
0
DISCUSSION
1
29
[ "B29", "B9", "B10" ]
20,507,904
pmid-19483709|pmid-19302050|pmid-16485027|pmid-18267068|pmid-17047224|pmid-15128824|pmid-17707233|pmid-14527995
Systematic approaches such as ChIP to CHIP experiments will help to address these important questions in the future.
[ "29", "9", "10" ]
116
43,039
0
false
Systematic approaches such as ChIP to CHIP experiments will help to address these important questions in the future.
[]
Systematic approaches such as ChIP to CHIP experiments will help to address these important questions in the future.
true
true
true
true
true
7,457
1
DISCUSSION
1
4
[ "B4", "B3", "B41", "B22", "B46 B47 B48", "B22", "B49", "B50", "B15", "B51" ]
20,507,904
pmid-19859064|pmid-18267068|pmid-16485027|pmid-16934762|pmid-18408078|pmid-18025230|pmid-18362169|pmid-19038492|pmid-18408078|pmid-15516339|pmid-20001970|pmid-19864627|pmid-18263619
Within a given cell type, stimulation with distinct NF-κB activating agents stereotypically allows the generation of DNA-binding dimers, while target gene expression displays clear differences in respect to the regulated genes (4).
[ "4", "3", "41", "22", "46–48", "22", "49", "50", "15", "51" ]
231
43,040
1
false
Within a given cell type, stimulation with distinct NF-κB activating agents stereotypically allows the generation of DNA-binding dimers, while target gene expression displays clear differences in respect to the regulated genes.
[ "4" ]
Within a given cell type, stimulation with distinct NF-κB activating agents stereotypically allows the generation of DNA-binding dimers, while target gene expression displays clear differences in respect to the regulated genes.
true
true
true
true
true
7,458
1
DISCUSSION
1
4
[ "B4", "B3", "B41", "B22", "B46 B47 B48", "B22", "B49", "B50", "B15", "B51" ]
20,507,904
pmid-19859064|pmid-18267068|pmid-16485027|pmid-16934762|pmid-18408078|pmid-18025230|pmid-18362169|pmid-19038492|pmid-18408078|pmid-15516339|pmid-20001970|pmid-19864627|pmid-18263619
In addition, co-regulated genes often show stimulus-specific dynamic parameters of the transcriptional response (3,41).
[ "4", "3", "41", "22", "46–48", "22", "49", "50", "15", "51" ]
119
43,041
0
false
In addition, co-regulated genes often show stimulus-specific dynamic parameters of the transcriptional response.
[ "3,41" ]
In addition, co-regulated genes often show stimulus-specific dynamic parameters of the transcriptional response.
true
true
true
true
true
7,458
1
DISCUSSION
1
4
[ "B4", "B3", "B41", "B22", "B46 B47 B48", "B22", "B49", "B50", "B15", "B51" ]
20,507,904
pmid-19859064|pmid-18267068|pmid-16485027|pmid-16934762|pmid-18408078|pmid-18025230|pmid-18362169|pmid-19038492|pmid-18408078|pmid-15516339|pmid-20001970|pmid-19864627|pmid-18263619
Our data support the idea that these key parameters are controlled by mechanisms that include post-translational modification of the DNA-binding subunits.
[ "4", "3", "41", "22", "46–48", "22", "49", "50", "15", "51" ]
154
43,042
0
false
Our data support the idea that these key parameters are controlled by mechanisms that include post-translational modification of the DNA-binding subunits.
[]
Our data support the idea that these key parameters are controlled by mechanisms that include post-translational modification of the DNA-binding subunits.
true
true
true
true
true
7,458
1
DISCUSSION
1
4
[ "B4", "B3", "B41", "B22", "B46 B47 B48", "B22", "B49", "B50", "B15", "B51" ]
20,507,904
pmid-19859064|pmid-18267068|pmid-16485027|pmid-16934762|pmid-18408078|pmid-18025230|pmid-18362169|pmid-19038492|pmid-18408078|pmid-15516339|pmid-20001970|pmid-19864627|pmid-18263619
This study shows that the impact of each individual phosphorylation site is highly gene specific and that reporter gene assays are therefore not adequate to investigate the functional consequences of NF-κB modifications.
[ "4", "3", "41", "22", "46–48", "22", "49", "50", "15", "51" ]
220
43,043
0
false
This study shows that the impact of each individual phosphorylation site is highly gene specific and that reporter gene assays are therefore not adequate to investigate the functional consequences of NF-κB modifications.
[]
This study shows that the impact of each individual phosphorylation site is highly gene specific and that reporter gene assays are therefore not adequate to investigate the functional consequences of NF-κB modifications.
true
true
true
true
true
7,458
1
DISCUSSION
1
4
[ "B4", "B3", "B41", "B22", "B46 B47 B48", "B22", "B49", "B50", "B15", "B51" ]
20,507,904
pmid-19859064|pmid-18267068|pmid-16485027|pmid-16934762|pmid-18408078|pmid-18025230|pmid-18362169|pmid-19038492|pmid-18408078|pmid-15516339|pmid-20001970|pmid-19864627|pmid-18263619
Our findings are in line with studies that extensively investigated the functional consequences of p65 serine 276 phosphorylation on gene expression (22,46–48).
[ "4", "3", "41", "22", "46–48", "22", "49", "50", "15", "51" ]
160
43,044
0
false
Our findings are in line with studies that extensively investigated the functional consequences of p65 serine 276 phosphorylation on gene expression.
[ "22,46–48" ]
Our findings are in line with studies that extensively investigated the functional consequences of p65 serine 276 phosphorylation on gene expression.
true
true
true
true
true
7,458
1
DISCUSSION
1
4
[ "B4", "B3", "B41", "B22", "B46 B47 B48", "B22", "B49", "B50", "B15", "B51" ]
20,507,904
pmid-19859064|pmid-18267068|pmid-16485027|pmid-16934762|pmid-18408078|pmid-18025230|pmid-18362169|pmid-19038492|pmid-18408078|pmid-15516339|pmid-20001970|pmid-19864627|pmid-18263619
The functional outcome for target gene transcription is strictly dependent on the individual phosphorylation site.
[ "4", "3", "41", "22", "46–48", "22", "49", "50", "15", "51" ]
114
43,045
0
false
The functional outcome for target gene transcription is strictly dependent on the individual phosphorylation site.
[]
The functional outcome for target gene transcription is strictly dependent on the individual phosphorylation site.
true
true
true
true
true
7,458
1
DISCUSSION
1
4
[ "B4", "B3", "B41", "B22", "B46 B47 B48", "B22", "B49", "B50", "B15", "B51" ]
20,507,904
pmid-19859064|pmid-18267068|pmid-16485027|pmid-16934762|pmid-18408078|pmid-18025230|pmid-18362169|pmid-19038492|pmid-18408078|pmid-15516339|pmid-20001970|pmid-19864627|pmid-18263619
For example, mutation of serine 276 impairs Icam-1 transcription (22,49), while this study shows that prevention of serine 468 or 536 phosphorylation stimulates Icam-1 expression.
[ "4", "3", "41", "22", "46–48", "22", "49", "50", "15", "51" ]
179
43,046
0
false
For example, mutation of serine 276 impairs Icam-1 transcription, while this study shows that prevention of serine 468 or 536 phosphorylation stimulates Icam-1 expression.
[ "22,49" ]
For example, mutation of serine 276 impairs Icam-1 transcription, while this study shows that prevention of serine 468 or 536 phosphorylation stimulates Icam-1 expression.
true
true
true
true
true
7,458
1
DISCUSSION
1
50
[ "B4", "B3", "B41", "B22", "B46 B47 B48", "B22", "B49", "B50", "B15", "B51" ]
20,507,904
pmid-19859064|pmid-18267068|pmid-16485027|pmid-16934762|pmid-18408078|pmid-18025230|pmid-18362169|pmid-19038492|pmid-18408078|pmid-15516339|pmid-20001970|pmid-19864627|pmid-18263619
While the Cxcl2 gene is not affected by serine 468 or 536 phosphorylation, a recent study revealed that expression of this gene is up-regulated by a phosphomimetic p65 threonine 435 aspartic acid mutant (50).
[ "4", "3", "41", "22", "46–48", "22", "49", "50", "15", "51" ]
208
43,047
1
false
While the Cxcl2 gene is not affected by serine 468 or 536 phosphorylation, a recent study revealed that expression of this gene is up-regulated by a phosphomimetic p65 threonine 435 aspartic acid mutant.
[ "50" ]
While the Cxcl2 gene is not affected by serine 468 or 536 phosphorylation, a recent study revealed that expression of this gene is up-regulated by a phosphomimetic p65 threonine 435 aspartic acid mutant.
true
true
true
true
true
7,458
1
DISCUSSION
1
4
[ "B4", "B3", "B41", "B22", "B46 B47 B48", "B22", "B49", "B50", "B15", "B51" ]
20,507,904
pmid-19859064|pmid-18267068|pmid-16485027|pmid-16934762|pmid-18408078|pmid-18025230|pmid-18362169|pmid-19038492|pmid-18408078|pmid-15516339|pmid-20001970|pmid-19864627|pmid-18263619
These gene-specific effects are not confined to phosphorylation sites, but have also been reported for p65 modifications by acetylation or monomethylation (15,51).
[ "4", "3", "41", "22", "46–48", "22", "49", "50", "15", "51" ]
163
43,048
0
false
These gene-specific effects are not confined to phosphorylation sites, but have also been reported for p65 modifications by acetylation or monomethylation.
[ "15,51" ]
These gene-specific effects are not confined to phosphorylation sites, but have also been reported for p65 modifications by acetylation or monomethylation.
true
true
true
true
true
7,458
1
DISCUSSION
1
4
[ "B4", "B3", "B41", "B22", "B46 B47 B48", "B22", "B49", "B50", "B15", "B51" ]
20,507,904
pmid-19859064|pmid-18267068|pmid-16485027|pmid-16934762|pmid-18408078|pmid-18025230|pmid-18362169|pmid-19038492|pmid-18408078|pmid-15516339|pmid-20001970|pmid-19864627|pmid-18263619
All these results are fully consistent with the NF-κB barcode hypothesis.
[ "4", "3", "41", "22", "46–48", "22", "49", "50", "15", "51" ]
73
43,049
0
false
All these results are fully consistent with the NF-κB barcode hypothesis.
[]
All these results are fully consistent with the NF-κB barcode hypothesis.
true
true
true
true
true
7,458
1
DISCUSSION
1
4
[ "B4", "B3", "B41", "B22", "B46 B47 B48", "B22", "B49", "B50", "B15", "B51" ]
20,507,904
pmid-19859064|pmid-18267068|pmid-16485027|pmid-16934762|pmid-18408078|pmid-18025230|pmid-18362169|pmid-19038492|pmid-18408078|pmid-15516339|pmid-20001970|pmid-19864627|pmid-18263619
According to this concept, post-translational modifications alone or in combination, generate distinct patterns that function to direct transcription in a target gene-specific fashion.
[ "4", "3", "41", "22", "46–48", "22", "49", "50", "15", "51" ]
184
43,050
0
false
According to this concept, post-translational modifications alone or in combination, generate distinct patterns that function to direct transcription in a target gene-specific fashion.
[]
According to this concept, post-translational modifications alone or in combination, generate distinct patterns that function to direct transcription in a target gene-specific fashion.
true
true
true
true
true
7,458
1
DISCUSSION
1
4
[ "B4", "B3", "B41", "B22", "B46 B47 B48", "B22", "B49", "B50", "B15", "B51" ]
20,507,904
pmid-19859064|pmid-18267068|pmid-16485027|pmid-16934762|pmid-18408078|pmid-18025230|pmid-18362169|pmid-19038492|pmid-18408078|pmid-15516339|pmid-20001970|pmid-19864627|pmid-18263619
Therefore it will be an important future task to identify the NF-κB modification patterns at different genomic NF-κB binding sites.
[ "4", "3", "41", "22", "46–48", "22", "49", "50", "15", "51" ]
131
43,051
0
false
Therefore it will be an important future task to identify the NF-κB modification patterns at different genomic NF-κB binding sites.
[]
Therefore it will be an important future task to identify the NF-κB modification patterns at different genomic NF-κB binding sites.
true
true
true
true
true
7,458
1
DISCUSSION
1
4
[ "B4", "B3", "B41", "B22", "B46 B47 B48", "B22", "B49", "B50", "B15", "B51" ]
20,507,904
pmid-19859064|pmid-18267068|pmid-16485027|pmid-16934762|pmid-18408078|pmid-18025230|pmid-18362169|pmid-19038492|pmid-18408078|pmid-15516339|pmid-20001970|pmid-19864627|pmid-18263619
These results may bear the seeds for a new generation of NF-κB inhibitors which do not preclude general NF-κB functions but rather interfere with distinct groups of target genes.
[ "4", "3", "41", "22", "46–48", "22", "49", "50", "15", "51" ]
178
43,052
0
false
These results may bear the seeds for a new generation of NF-κB inhibitors which do not preclude general NF-κB functions but rather interfere with distinct groups of target genes.
[]
These results may bear the seeds for a new generation of NF-κB inhibitors which do not preclude general NF-κB functions but rather interfere with distinct groups of target genes.
true
true
true
true
true
7,458
2
DISCUSSION
1
31
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
In unstimulated cells, most of the endogenous IKKε protein is found in the cytosol, while a minor fraction localizes to nuclear speckles which most probably correspond to PML-NBs.
[ "31", "52–56", "57", "58", "59" ]
179
43,053
0
false
In unstimulated cells, most of the endogenous IKKε protein is found in the cytosol, while a minor fraction localizes to nuclear speckles which most probably correspond to PML-NBs.
[]
In unstimulated cells, most of the endogenous IKKε protein is found in the cytosol, while a minor fraction localizes to nuclear speckles which most probably correspond to PML-NBs.
true
true
true
true
true
7,459
2
DISCUSSION
1
31
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
This constitutively nuclear fraction of IKKε can be found at very low levels in the promoter regions of specific genes such as Saa3 or Vcam1.
[ "31", "52–56", "57", "58", "59" ]
141
43,054
0
false
This constitutively nuclear fraction of IKKε can be found at very low levels in the promoter regions of specific genes such as Saa3 or Vcam1.
[]
This constitutively nuclear fraction of IKKε can be found at very low levels in the promoter regions of specific genes such as Saa3 or Vcam1.
true
true
true
true
true
7,459
2
DISCUSSION
1
31
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
The relevance of the kinase activity for basal nuclear IKKε localization was seen by the analysis of the kinase inactive IKKε variant which was completely excluded from the nucleus.
[ "31", "52–56", "57", "58", "59" ]
181
43,055
0
false
The relevance of the kinase activity for basal nuclear IKKε localization was seen by the analysis of the kinase inactive IKKε variant which was completely excluded from the nucleus.
[]
The relevance of the kinase activity for basal nuclear IKKε localization was seen by the analysis of the kinase inactive IKKε variant which was completely excluded from the nucleus.
true
true
true
true
true
7,459
2
DISCUSSION
1
31
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
But the kinase function of IKKε is also important for the TNF-induced nuclear import of IKKε.
[ "31", "52–56", "57", "58", "59" ]
93
43,056
0
false
But the kinase function of IKKε is also important for the TNF-induced nuclear import of IKKε.
[]
But the kinase function of IKKε is also important for the TNF-induced nuclear import of IKKε.
true
true
true
true
true
7,459
2
DISCUSSION
1
31
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
A sequence inspection of IKKε did not reveal any obvious sequences with the potential to mediate nuclear import or export, suggesting that IKKε reaches the nucleus upon binding to a binding partner by a piggyback mechanism.
[ "31", "52–56", "57", "58", "59" ]
223
43,057
0
false
A sequence inspection of IKKε did not reveal any obvious sequences with the potential to mediate nuclear import or export, suggesting that IKKε reaches the nucleus upon binding to a binding partner by a piggyback mechanism.
[]
A sequence inspection of IKKε did not reveal any obvious sequences with the potential to mediate nuclear import or export, suggesting that IKKε reaches the nucleus upon binding to a binding partner by a piggyback mechanism.
true
true
true
true
true
7,459
2
DISCUSSION
1
31
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
Accordingly, TNF stimulation allowed the phosphorylation-dependent association of IKKε to p65 (see Figure 6B).
[ "31", "52–56", "57", "58", "59" ]
110
43,058
0
false
Accordingly, TNF stimulation allowed the phosphorylation-dependent association of IKKε to p65 (see Figure 6B).
[]
Accordingly, TNF stimulation allowed the phosphorylation-dependent association of IKKε to p65 (see Figure 6B).
true
true
true
true
true
7,459
2
DISCUSSION
1
31
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
The stimulus-induced interaction between IKKε and p65, and an absent interaction in unstimulated cells is also compatible with the leptomycin B experiments.
[ "31", "52–56", "57", "58", "59" ]
156
43,059
0
false
The stimulus-induced interaction between IKKε and p65, and an absent interaction in unstimulated cells is also compatible with the leptomycin B experiments.
[]
The stimulus-induced interaction between IKKε and p65, and an absent interaction in unstimulated cells is also compatible with the leptomycin B experiments.
true
true
true
true
true
7,459
2
DISCUSSION
1
31
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
These revealed nuclear accumulation of p65 but cytosolic localization of IKKε after blockage of nuclear export and in the absence of a stimulatory signal.
[ "31", "52–56", "57", "58", "59" ]
154
43,060
0
false
These revealed nuclear accumulation of p65 but cytosolic localization of IKKε after blockage of nuclear export and in the absence of a stimulatory signal.
[]
These revealed nuclear accumulation of p65 but cytosolic localization of IKKε after blockage of nuclear export and in the absence of a stimulatory signal.
true
true
true
true
true
7,459
2
DISCUSSION
1
31
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
The role of p65 for nuclear import of IKKε was suggested by a lacking nuclear translocation of the kinase in p65−/− cells, but also by the parallel kinetics of IKKε and p65 during TNF-induced nuclear import and export.
[ "31", "52–56", "57", "58", "59" ]
218
43,061
0
false
The role of p65 for nuclear import of IKKε was suggested by a lacking nuclear translocation of the kinase in p65−/− cells, but also by the parallel kinetics of IKKε and p65 during TNF-induced nuclear import and export.
[]
The role of p65 for nuclear import of IKKε was suggested by a lacking nuclear translocation of the kinase in p65−/− cells, but also by the parallel kinetics of IKKε and p65 during TNF-induced nuclear import and export.
true
true
true
true
true
7,459
2
DISCUSSION
1
31
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
Accordingly, a recent study showed the necessity of p65 for the recruitment of IKKε to the Inos promoter (31).
[ "31", "52–56", "57", "58", "59" ]
110
43,062
1
false
Accordingly, a recent study showed the necessity of p65 for the recruitment of IKKε to the Inos promoter.
[ "31" ]
Accordingly, a recent study showed the necessity of p65 for the recruitment of IKKε to the Inos promoter.
true
true
true
true
true
7,459
2
DISCUSSION
1
52–56
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
In addition to p65, IKKε also phosphorylates further transcription factors including c-Rel, c-Jun, IRF3 and IRF7 (52–56).
[ "31", "52–56", "57", "58", "59" ]
121
43,063
1
false
In addition to p65, IKKε also phosphorylates further transcription factors including c-Rel, c-Jun, IRF3 and IRF7.
[ "52–56" ]
In addition to p65, IKKε also phosphorylates further transcription factors including c-Rel, c-Jun, IRF3 and IRF7.
true
true
true
true
true
7,459
2
DISCUSSION
1
31
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
It will therefore be interesting to reveal a possible contribution of these proteins for the regulated nuclear uptake of IKKε.
[ "31", "52–56", "57", "58", "59" ]
126
43,064
0
false
It will therefore be interesting to reveal a possible contribution of these proteins for the regulated nuclear uptake of IKKε.
[]
It will therefore be interesting to reveal a possible contribution of these proteins for the regulated nuclear uptake of IKKε.
true
true
true
true
true
7,459
2
DISCUSSION
1
31
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
Within the nucleus, IKKε can be found in the nucleoplasm and also partially in PML-NBs.
[ "31", "52–56", "57", "58", "59" ]
87
43,065
0
false
Within the nucleus, IKKε can be found in the nucleoplasm and also partially in PML-NBs.
[]
Within the nucleus, IKKε can be found in the nucleoplasm and also partially in PML-NBs.
true
true
true
true
true
7,459
2
DISCUSSION
1
57
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
The integrity of these subnuclear structures depends on a PML domain which allows non-covalent binding to SUMO (57).
[ "31", "52–56", "57", "58", "59" ]
116
43,066
1
false
The integrity of these subnuclear structures depends on a PML domain which allows non-covalent binding to SUMO.
[ "57" ]
The integrity of these subnuclear structures depends on a PML domain which allows non-covalent binding to SUMO.
true
true
true
true
true
7,459
2
DISCUSSION
1
58
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
Intriguingly, the vast majority of constitutive or inducible PML-NB resident proteins can be modified by SUMOylation, thus allowing the formation of protein meshworks that are glued together upon interaction of SUMO and SUMO-binding domains (58).
[ "31", "52–56", "57", "58", "59" ]
246
43,067
1
false
Intriguingly, the vast majority of constitutive or inducible PML-NB resident proteins can be modified by SUMOylation, thus allowing the formation of protein meshworks that are glued together upon interaction of SUMO and SUMO-binding domains.
[ "58" ]
Intriguingly, the vast majority of constitutive or inducible PML-NB resident proteins can be modified by SUMOylation, thus allowing the formation of protein meshworks that are glued together upon interaction of SUMO and SUMO-binding domains.
true
true
true
true
true
7,459
2
DISCUSSION
1
59
[ "B31", "B52 B53 B54 B55 B56", "B57", "B58", "B59" ]
20,507,904
pmid-18927578|pmid-16485027|pmid-14532125|pmid-17707233|pmid-17707233|pmid-14527995|pmid-18927578|pmid-19595715|pmid-16888014|pmid-15879144|pmid-17332413|NA|pmid-12702806|pmid-17081985|pmid-17545995|pmid-20188669
The reversible retention of IKKε in PML-NBs may thus be explained by the recently discovered SUMOylation of this kinase (59).
[ "31", "52–56", "57", "58", "59" ]
125
43,068
1
false
The reversible retention of IKKε in PML-NBs may thus be explained by the recently discovered SUMOylation of this kinase.
[ "59" ]
The reversible retention of IKKε in PML-NBs may thus be explained by the recently discovered SUMOylation of this kinase.
true
true
true
true
true
7,459
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
This study shows that Saa3 activation is dependent on p65 phosphorylation and also sensitive to IKKε expression, thus fitting a model where IKKε-mediated p65 phosphorylation is relevant for gene activation.
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
206
43,069
0
false
This study shows that Saa3 activation is dependent on p65 phosphorylation and also sensitive to IKKε expression, thus fitting a model where IKKε-mediated p65 phosphorylation is relevant for gene activation.
[]
This study shows that Saa3 activation is dependent on p65 phosphorylation and also sensitive to IKKε expression, thus fitting a model where IKKε-mediated p65 phosphorylation is relevant for gene activation.
true
true
true
true
true
7,460
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
On the contrary, while Vcam1 similarly requires IKKε for optimal activation, loss of phosphorylation sites actually results in greater induction.
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
145
43,070
0
false
On the contrary, while Vcam1 similarly requires IKKε for optimal activation, loss of phosphorylation sites actually results in greater induction.
[]
On the contrary, while Vcam1 similarly requires IKKε for optimal activation, loss of phosphorylation sites actually results in greater induction.
true
true
true
true
true
7,460
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
This suggests that there are yet further targets of IKKε phosphorylation that are relevant at least for Vcam1 expression or more generally, for the effect of IKKε mediated activation, as schematically summarized in Figure 8D.
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
225
43,071
0
false
This suggests that there are yet further targets of IKKε phosphorylation that are relevant at least for Vcam1 expression or more generally, for the effect of IKKε mediated activation, as schematically summarized in Figure 8D.
[]
This suggests that there are yet further targets of IKKε phosphorylation that are relevant at least for Vcam1 expression or more generally, for the effect of IKKε mediated activation, as schematically summarized in Figure 8D.
true
true
true
true
true
7,460
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
Accordingly, recent data show that inducible chromatin recruitment of IKKε allows the c-Jun-dependent clearance of the corepressor NCoR from target promoters (31).
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
163
43,072
1
false
Accordingly, recent data show that inducible chromatin recruitment of IKKε allows the c-Jun-dependent clearance of the corepressor NCoR from target promoters.
[ "31" ]
Accordingly, recent data show that inducible chromatin recruitment of IKKε allows the c-Jun-dependent clearance of the corepressor NCoR from target promoters.
true
true
true
true
true
7,460
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
This would also explain the occurrence of IKKε at loci which control the expression of IKKε-independent genes.
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
110
43,073
0
false
This would also explain the occurrence of IKKε at loci which control the expression of IKKε-independent genes.
[]
This would also explain the occurrence of IKKε at loci which control the expression of IKKε-independent genes.
true
true
true
true
true
7,460
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
The recent years have mounted evidence that some cytosolic components of the NF-κB signaling cascade (including IKKα, p38, GSK3β, COMMD1, etc.)
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
143
43,074
0
false
The recent years have mounted evidence that some cytosolic components of the NF-κB signaling cascade (including IKKα, p38, GSK3β, COMMD1, etc.)
[]
The recent years have mounted evidence that some cytosolic components of the NF-κB signaling cascade
true
true
false
true
false
7,460
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
can also be found at selected NF-κB target genes where they participate in modification of the DNA-binding subunits or chromatin (7,60).
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
136
43,075
0
false
can also be found at selected NF-κB target genes where they participate in modification of the DNA-binding subunits or chromatin.
[ "7,60" ]
can also be found at selected NF-κB target genes where they participate in modification of the DNA-binding subunits or chromatin.
false
true
true
true
false
7,460
3
DISCUSSION
1
63
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
The IKKε-related IKKα protein, for example, regulates gene expression upon phosphorylation of histone H3 at serine 10 (61,62), the corepressor SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) (63) and the acetyl transferase CBP (64).
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
256
43,076
1
false
The IKKε-related IKKα protein, for example, regulates gene expression upon phosphorylation of histone H3 at serine 10, the corepressor SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and the acetyl transferase CBP.
[ "61,62", "63", "64" ]
The IKKε-related IKKα protein, for example, regulates gene expression upon phosphorylation of histone H3 at serine 10, the corepressor SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and the acetyl transferase CBP.
true
true
true
true
true
7,460
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
Also IKKα was found to associate with chromatin at control regions for the cIAP-2, Il-8 or Maspin genes (63,65), but the general mechanisms employed by IKKs to allow chromatin association remain to be elaborated.
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
212
43,077
0
false
Also IKKα was found to associate with chromatin at control regions for the cIAP-2, Il-8 or Maspin genes, but the general mechanisms employed by IKKs to allow chromatin association remain to be elaborated.
[ "63,65" ]
Also IKKα was found to associate with chromatin at control regions for the cIAP-2, Il-8 or Maspin genes, but the general mechanisms employed by IKKs to allow chromatin association remain to be elaborated.
true
true
true
true
true
7,460
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
Our Re-ChIP experiments suggest that chromatin association via binding to p65 might only be relevant for a subset of binding sites, as they occur at the Saa3 and Vcam1 promoters.
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
178
43,078
0
false
Our Re-ChIP experiments suggest that chromatin association via binding to p65 might only be relevant for a subset of binding sites, as they occur at the Saa3 and Vcam1 promoters.
[]
Our Re-ChIP experiments suggest that chromatin association via binding to p65 might only be relevant for a subset of binding sites, as they occur at the Saa3 and Vcam1 promoters.
true
true
true
true
true
7,460
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
Consistently and as exemplified by the Saa3 promoter, phosphorylation-dependent binding of IKKε to p65 is required for chromatin recruitment of IKKε (see also Figure 6C).
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
170
43,079
0
false
Consistently and as exemplified by the Saa3 promoter, phosphorylation-dependent binding of IKKε to p65 is required for chromatin recruitment of IKKε (see also Figure 6C).
[]
Consistently and as exemplified by the Saa3 promoter, phosphorylation-dependent binding of IKKε to p65 is required for chromatin recruitment of IKKε (see also Figure 6C).
true
true
true
true
true
7,460
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
A detailed understanding of the mechanisms underlying chromatin recruitment of IKKs will therefore require unbiased and systematic genome-wide approaches.
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
154
43,080
0
false
A detailed understanding of the mechanisms underlying chromatin recruitment of IKKs will therefore require unbiased and systematic genome-wide approaches.
[]
A detailed understanding of the mechanisms underlying chromatin recruitment of IKKs will therefore require unbiased and systematic genome-wide approaches.
true
true
true
true
true
7,460
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
This study also revealed the relevance of PML for appropriate targeting of IKKε to the nucleus.
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
95
43,081
0
false
This study also revealed the relevance of PML for appropriate targeting of IKKε to the nucleus.
[]
This study also revealed the relevance of PML for appropriate targeting of IKKε to the nucleus.
true
true
true
true
true
7,460
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
Accordingly, cells expressing the oncogenic and dominant negative PML-RARα fusion protein failed to display inducible nuclear localization of IKKε.
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
147
43,082
0
false
Accordingly, cells expressing the oncogenic and dominant negative PML-RARα fusion protein failed to display inducible nuclear localization of IKKε.
[]
Accordingly, cells expressing the oncogenic and dominant negative PML-RARα fusion protein failed to display inducible nuclear localization of IKKε.
true
true
true
true
true
7,460
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
This defect is rather attributable to delayed nuclear import and not to enhanced nuclear export, as PML-RARα-dependent blockage of TNF-triggered IKKε translocation occurred even in the presence of leptomycin B (Supplementary Figure S4).
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
236
43,083
0
false
This defect is rather attributable to delayed nuclear import and not to enhanced nuclear export, as PML-RARα-dependent blockage of TNF-triggered IKKε translocation occurred even in the presence of leptomycin B (Supplementary Figure S4).
[]
This defect is rather attributable to delayed nuclear import and not to enhanced nuclear export, as PML-RARα-dependent blockage of TNF-triggered IKKε translocation occurred even in the presence of leptomycin B (Supplementary Figure S4).
true
true
true
true
true
7,460
3
DISCUSSION
1
66
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
This finding might explain the recently revealed dysregulation of the IKKε target gene Vcam1 that occurs in acute promyelocytic leukemia cells (66).
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
148
43,084
1
false
This finding might explain the recently revealed dysregulation of the IKKε target gene Vcam1 that occurs in acute promyelocytic leukemia cells.
[ "66" ]
This finding might explain the recently revealed dysregulation of the IKKε target gene Vcam1 that occurs in acute promyelocytic leukemia cells.
true
true
true
true
true
7,460
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
Aberrant gene expression of further IKKε-controlled genes would not be unexpected in acute promyelocytic leukemia cells, thus adding another example for the interplay between two oncogenes.
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
189
43,085
0
false
Aberrant gene expression of further IKKε-controlled genes would not be unexpected in acute promyelocytic leukemia cells, thus adding another example for the interplay between two oncogenes.
[]
Aberrant gene expression of further IKKε-controlled genes would not be unexpected in acute promyelocytic leukemia cells, thus adding another example for the interplay between two oncogenes.
true
true
true
true
true
7,460
3
DISCUSSION
1
31
[ "B31", "B7", "B60", "B61", "B62", "B63", "B64", "B63", "B65", "B66" ]
20,507,904
pmid-15226358|pmid-8710491|pmid-11533489|pmid-14690596|pmid-19864627|pmid-7925300|pmid-12419806|pmid-12456660|pmid-9660950|pmid-15457532|pmid-17431096|pmid-18408078|pmid-9660950|pmid-15489227|pmid-19339690|pmid-19270718|pmid-17468759|pmid-17928811|pmid-19595715|pmid-18927578|pmid-19648011|pmid-12789343|pmid-12789342|pm...
Given the role of IKKε intracellular localization revealed here, it will also be relevant to investigate whether cancer cells overexpressing IKKε also show changes in the intracellular localisation of this breast cancer oncogene.
[ "31", "7", "60", "61", "62", "63", "64", "63", "65", "66" ]
229
43,086
0
false
Given the role of IKKε intracellular localization revealed here, it will also be relevant to investigate whether cancer cells overexpressing IKKε also show changes in the intracellular localisation of this breast cancer oncogene.
[]
Given the role of IKKε intracellular localization revealed here, it will also be relevant to investigate whether cancer cells overexpressing IKKε also show changes in the intracellular localisation of this breast cancer oncogene.
true
true
true
true
true
7,460
0
DISCUSSION
1
30
[ "bib30", "bib31", "bib33", "bib5", "bib24", "bib34" ]
16,157,683
pmid-12574382|pmid-15485625|pmid-10679127|pmid-9922218|pmid-15356157|pmid-15546388
Our current studies show that IL-23 is required for the in vivo pulmonary IL-17 and IL-17F response to K. pneumoniae infection.
[ "30", "31", "33", "5", "24", "34" ]
127
43,087
0
false
Our current studies show that IL-23 is required for the in vivo pulmonary IL-17 and IL-17F response to K. pneumoniae infection.
[]
Our current studies show that IL-23 is required for the in vivo pulmonary IL-17 and IL-17F response to K. pneumoniae infection.
true
true
true
true
true
7,461
0
DISCUSSION
1
30
[ "bib30", "bib31", "bib33", "bib5", "bib24", "bib34" ]
16,157,683
pmid-12574382|pmid-15485625|pmid-10679127|pmid-9922218|pmid-15356157|pmid-15546388
These results are novel in the light of previous work suggesting other cytokine signals, namely IL-15, are responsible for the pulmonary IL-17 response to lipopolysaccharide (30).
[ "30", "31", "33", "5", "24", "34" ]
179
43,088
1
false
These results are novel in the light of previous work suggesting other cytokine signals, namely IL-15, are responsible for the pulmonary IL-17 response to lipopolysaccharide.
[ "30" ]
These results are novel in the light of previous work suggesting other cytokine signals, namely IL-15, are responsible for the pulmonary IL-17 response to lipopolysaccharide.
true
true
true
true
true
7,461
0
DISCUSSION
1
30
[ "bib30", "bib31", "bib33", "bib5", "bib24", "bib34" ]
16,157,683
pmid-12574382|pmid-15485625|pmid-10679127|pmid-9922218|pmid-15356157|pmid-15546388
Although IL-15 appears to play a role in IL-17 induction in other models of inflammation (31–33), our current data demonstrate a strict requirement for IL-23 in pulmonary IL-17/17F induction in response to K. pneumoniae challenge.
[ "30", "31", "33", "5", "24", "34" ]
230
43,089
0
false
Although IL-15 appears to play a role in IL-17 induction in other models of inflammation, our current data demonstrate a strict requirement for IL-23 in pulmonary IL-17/17F induction in response to K. pneumoniae challenge.
[ "31–33" ]
Although IL-15 appears to play a role in IL-17 induction in other models of inflammation, our current data demonstrate a strict requirement for IL-23 in pulmonary IL-17/17F induction in response to K. pneumoniae challenge.
true
true
true
true
true
7,461
0
DISCUSSION
1
30
[ "bib30", "bib31", "bib33", "bib5", "bib24", "bib34" ]
16,157,683
pmid-12574382|pmid-15485625|pmid-10679127|pmid-9922218|pmid-15356157|pmid-15546388
Our current work also identifies two potential sources of IL-23 in the lung—AMs and mDCs—and suggests IL-23 functions very early in lung response to pathogen compared with IL-12.
[ "30", "31", "33", "5", "24", "34" ]
178
43,090
0
false
Our current work also identifies two potential sources of IL-23 in the lung—AMs and mDCs—and suggests IL-23 functions very early in lung response to pathogen compared with IL-12.
[]
Our current work also identifies two potential sources of IL-23 in the lung—AMs and mDCs—and suggests IL-23 functions very early in lung response to pathogen compared with IL-12.
true
true
true
true
true
7,461
0
DISCUSSION
1
30
[ "bib30", "bib31", "bib33", "bib5", "bib24", "bib34" ]
16,157,683
pmid-12574382|pmid-15485625|pmid-10679127|pmid-9922218|pmid-15356157|pmid-15546388
As early as 4 h after in vitro exposure to bacteria, media from AM culture stimulates splenocyte IL-17 production, indicating a rapid induction of bioactive IL-23 (unpublished data).
[ "30", "31", "33", "5", "24", "34" ]
182
43,091
0
false
As early as 4 h after in vitro exposure to bacteria, media from AM culture stimulates splenocyte IL-17 production, indicating a rapid induction of bioactive IL-23 (unpublished data).
[]
As early as 4 h after in vitro exposure to bacteria, media from AM culture stimulates splenocyte IL-17 production, indicating a rapid induction of bioactive IL-23 (unpublished data).
true
true
true
true
true
7,461
0
DISCUSSION
1
30
[ "bib30", "bib31", "bib33", "bib5", "bib24", "bib34" ]
16,157,683
pmid-12574382|pmid-15485625|pmid-10679127|pmid-9922218|pmid-15356157|pmid-15546388
In contrast, IL-12 remained undetectable in AM culture supernatants even 24 h after in vitro challenge, and these supernatants did not induce splenocyte IFN-γ expression.
[ "30", "31", "33", "5", "24", "34" ]
170
43,092
0
false
In contrast, IL-12 remained undetectable in AM culture supernatants even 24 h after in vitro challenge, and these supernatants did not induce splenocyte IFN-γ expression.
[]
In contrast, IL-12 remained undetectable in AM culture supernatants even 24 h after in vitro challenge, and these supernatants did not induce splenocyte IFN-γ expression.
true
true
true
true
true
7,461
0
DISCUSSION
1
30
[ "bib30", "bib31", "bib33", "bib5", "bib24", "bib34" ]
16,157,683
pmid-12574382|pmid-15485625|pmid-10679127|pmid-9922218|pmid-15356157|pmid-15546388
These findings are consistent with prior work showing that AMs produce little or no IL-12 p70 in response to isolated challenge with K. pneumoniae or LPS (5, 24).
[ "30", "31", "33", "5", "24", "34" ]
162
43,093
0
false
These findings are consistent with prior work showing that AMs produce little or no IL-12 p70 in response to isolated challenge with K. pneumoniae or LPS.
[ "5, 24" ]
These findings are consistent with prior work showing that AMs produce little or no IL-12 p70 in response to isolated challenge with K. pneumoniae or LPS.
true
true
true
true
true
7,461
0
DISCUSSION
1
34
[ "bib30", "bib31", "bib33", "bib5", "bib24", "bib34" ]
16,157,683
pmid-12574382|pmid-15485625|pmid-10679127|pmid-9922218|pmid-15356157|pmid-15546388
Hence, AM may be more important in initiating the early “ThIL-17” response to this pathogen rather than directing T cells into Th1 polarization (34).
[ "30", "31", "33", "5", "24", "34" ]
149
43,094
1
false
Hence, AM may be more important in initiating the early “ThIL-17” response to this pathogen rather than directing T cells into Th1 polarization.
[ "34" ]
Hence, AM may be more important in initiating the early “ThIL-17” response to this pathogen rather than directing T cells into Th1 polarization.
true
true
true
true
true
7,461
1
DISCUSSION
0
null
null
16,157,683
null
In vivo, up-regulation of IL-23 p19 in BAL cells is seen as early as 2 h after K. pneumoniae infection.
null
103
43,095
0
false
null
null
In vivo, up-regulation of IL-23 p19 in BAL cells is seen as early as 2 h after K. pneumoniae infection.
true
true
true
true
true
7,462
1
DISCUSSION
0
null
null
16,157,683
null
Cells obtained by BAL at this time are still more than 95% AMs, implicating these cells as the likely source of early IL-23 expression in the alveolar compartment, because they express p40 mRNA even before infection.
null
216
43,096
0
false
null
null
Cells obtained by BAL at this time are still more than 95% AMs, implicating these cells as the likely source of early IL-23 expression in the alveolar compartment, because they express p40 mRNA even before infection.
true
true
true
true
true
7,462
1
DISCUSSION
0
null
null
16,157,683
null
Hence, induction of p19 transcription likely regulates the onset of IL-23 production in air spaces.
null
99
43,097
0
false
null
null
Hence, induction of p19 transcription likely regulates the onset of IL-23 production in air spaces.
true
true
true
true
true
7,462
1
DISCUSSION
0
null
null
16,157,683
null
The early increase in BAL cell p19 mRNA is followed by greater expression 16–24 h after infection, a pattern observed in both BALF cells and lung homogenate.
null
157
43,098
0
false
null
null
The early increase in BAL cell p19 mRNA is followed by greater expression 16–24 h after infection, a pattern observed in both BALF cells and lung homogenate.
true
true
true
true
true
7,462
1
DISCUSSION
0
null
null
16,157,683
null
Whether this finding is due to the alveolar recruitment of additional cell types expressing IL-23 p19 or increased AM gene expression is unknown.
null
145
43,099
0
false
null
null
Whether this finding is due to the alveolar recruitment of additional cell types expressing IL-23 p19 or increased AM gene expression is unknown.
true
true
true
true
true
7,462
2
DISCUSSION
1
17
[ "bib17", "bib5", "bib35" ]
16,157,683
pmid-12417590|pmid-9922218|NA
Interestingly, we observed greater splenocyte IL-17 induction from bacteria-pulsed IL-12 p35−/− AM conditioned media compared with WT AM.
[ "17", "5", "35" ]
137
43,100
0
false
Interestingly, we observed greater splenocyte IL-17 induction from bacteria-pulsed IL-12 p35−/− AM conditioned media compared with WT AM.
[]
Interestingly, we observed greater splenocyte IL-17 induction from bacteria-pulsed IL-12 p35−/− AM conditioned media compared with WT AM.
true
true
true
true
true
7,463
2
DISCUSSION
1
17
[ "bib17", "bib5", "bib35" ]
16,157,683
pmid-12417590|pmid-9922218|NA
A regulatory role for IL-12 in IL-23–mediated signaling has been previously demonstrated (17), because IL-12 and IL-23 share a common p40 subunit and both require IL-12Rβ1 binding to signal.
[ "17", "5", "35" ]
190
43,101
1
false
A regulatory role for IL-12 in IL-23–mediated signaling has been previously demonstrated, because IL-12 and IL-23 share a common p40 subunit and both require IL-12Rβ1 binding to signal.
[ "17" ]
A regulatory role for IL-12 in IL-23–mediated signaling has been previously demonstrated, because IL-12 and IL-23 share a common p40 subunit and both require IL-12Rβ1 binding to signal.
true
true
true
true
true
7,463
2
DISCUSSION
1
17
[ "bib17", "bib5", "bib35" ]
16,157,683
pmid-12417590|pmid-9922218|NA
However, we were unable to measure IL-12 p70 in bacteria-stimulated AM supernatants, regardless of genotype.
[ "17", "5", "35" ]
108
43,102
0
false
However, we were unable to measure IL-12 p70 in bacteria-stimulated AM supernatants, regardless of genotype.
[]
However, we were unable to measure IL-12 p70 in bacteria-stimulated AM supernatants, regardless of genotype.
true
true
true
true
true
7,463
2
DISCUSSION
1
17
[ "bib17", "bib5", "bib35" ]
16,157,683
pmid-12417590|pmid-9922218|NA
One hypothesis is that AM production of bioactive IL-23 is greater in p35−/− AMs, because more intracellular p40 is available to combine with p19.
[ "17", "5", "35" ]
146
43,103
0
false
One hypothesis is that AM production of bioactive IL-23 is greater in p35−/− AMs, because more intracellular p40 is available to combine with p19.
[]
One hypothesis is that AM production of bioactive IL-23 is greater in p35−/− AMs, because more intracellular p40 is available to combine with p19.
true
true
true
true
true
7,463
2
DISCUSSION
1
5
[ "bib17", "bib5", "bib35" ]
16,157,683
pmid-12417590|pmid-9922218|NA
In support of this is, it has been shown that the elaboration of IL-12 p70 in AMs is under posttranscriptional control, and a second stimulus (such as IFN-γ) (5) is required for AM release of IL-12 p70 heterodimer in response to LPS.
[ "17", "5", "35" ]
233
43,104
1
false
In support of this is, it has been shown that the elaboration of IL-12 p70 in AMs is under posttranscriptional control, and a second stimulus (such as IFN-γ) is required for AM release of IL-12 p70 heterodimer in response to LPS.
[ "5" ]
In support of this is, it has been shown that the elaboration of IL-12 p70 in AMs is under posttranscriptional control, and a second stimulus (such as IFN-γ) is required for AM release of IL-12 p70 heterodimer in response to LPS.
true
true
true
true
true
7,463
2
DISCUSSION
1
17
[ "bib17", "bib5", "bib35" ]
16,157,683
pmid-12417590|pmid-9922218|NA
Of note, higher IL-17 levels in IL-12 p35−/− mice was not observed in vivo.
[ "17", "5", "35" ]
75
43,105
0
false
Of note, higher IL-17 levels in IL-12 p35−/− mice was not observed in vivo.
[]
Of note, higher IL-17 levels in IL-12 p35−/− mice was not observed in vivo.
true
true
true
true
true
7,463
2
DISCUSSION
1
35
[ "bib17", "bib5", "bib35" ]
16,157,683
pmid-12417590|pmid-9922218|NA
However, deficient STAT1 signaling results in augmented IL-23 and IL-17 expression in the context of respiratory syncytial virus infection (35).
[ "17", "5", "35" ]
144
43,106
1
false
However, deficient STAT1 signaling results in augmented IL-23 and IL-17 expression in the context of respiratory syncytial virus infection.
[ "35" ]
However, deficient STAT1 signaling results in augmented IL-23 and IL-17 expression in the context of respiratory syncytial virus infection.
true
true
true
true
true
7,463
3
DISCUSSION
1
23
[ "bib23", "bib28", "bib36" ]
16,157,683
pmid-12707317|pmid-12515817|pmid-8217188
Our prior work has shown that TLR4 signaling is required for early IL-23 p19 and IL-17 mRNA expression in the lung challenged with K. pneumoniae (23).
[ "23", "28", "36" ]
150
43,107
1
false
Our prior work has shown that TLR4 signaling is required for early IL-23 p19 and IL-17 mRNA expression in the lung challenged with K. pneumoniae.
[ "23" ]
Our prior work has shown that TLR4 signaling is required for early IL-23 p19 and IL-17 mRNA expression in the lung challenged with K. pneumoniae.
true
true
true
true
true
7,464
3
DISCUSSION
1
28
[ "bib23", "bib28", "bib36" ]
16,157,683
pmid-12707317|pmid-12515817|pmid-8217188
The greater up-regulation in p19 mRNA seen in mDCs compared with pDCs also supports a TLR4-dependent mechanism for IL-23 expression in this model, because granulocyte macrophage CSF–treated, bone marrow–derived mDCs are reported to express greater amounts of TLR4 and are more responsive to LPS than Flt3 ligand-generate...
[ "23", "28", "36" ]
332
43,108
1
false
The greater up-regulation in p19 mRNA seen in mDCs compared with pDCs also supports a TLR4-dependent mechanism for IL-23 expression in this model, because granulocyte macrophage CSF–treated, bone marrow–derived mDCs are reported to express greater amounts of TLR4 and are more responsive to LPS than Flt3 ligand-generate...
[ "28" ]
The greater up-regulation in p19 mRNA seen in mDCs compared with pDCs also supports a TLR4-dependent mechanism for IL-23 expression in this model, because granulocyte macrophage CSF–treated, bone marrow–derived mDCs are reported to express greater amounts of TLR4 and are more responsive to LPS than Flt3 ligand-generate...
true
true
true
true
true
7,464
3
DISCUSSION
1
36
[ "bib23", "bib28", "bib36" ]
16,157,683
pmid-12707317|pmid-12515817|pmid-8217188
Our data lead us to speculate that mDCs play an important role in the IL-17 recall response to bacterial challenge as mDCs readily migrate to draining lymph nodes upon antigen capture, a function not readily shared by AMs (36).
[ "23", "28", "36" ]
227
43,109
1
false
Our data lead us to speculate that mDCs play an important role in the IL-17 recall response to bacterial challenge as mDCs readily migrate to draining lymph nodes upon antigen capture, a function not readily shared by AMs.
[ "36" ]
Our data lead us to speculate that mDCs play an important role in the IL-17 recall response to bacterial challenge as mDCs readily migrate to draining lymph nodes upon antigen capture, a function not readily shared by AMs.
true
true
true
true
true
7,464
3
DISCUSSION
1
23
[ "bib23", "bib28", "bib36" ]
16,157,683
pmid-12707317|pmid-12515817|pmid-8217188
The subsequent T cell expansion, IL-17 expression, and augmented neutrophil recruitment as a result of the IL-23/IL-17 axis may represent a novel “cross-talk” loop between innate and adaptive pulmonary immunity, which enables the infected lung to more rapidly contain infection.
[ "23", "28", "36" ]
278
43,110
0
false
The subsequent T cell expansion, IL-17 expression, and augmented neutrophil recruitment as a result of the IL-23/IL-17 axis may represent a novel “cross-talk” loop between innate and adaptive pulmonary immunity, which enables the infected lung to more rapidly contain infection.
[]
The subsequent T cell expansion, IL-17 expression, and augmented neutrophil recruitment as a result of the IL-23/IL-17 axis may represent a novel “cross-talk” loop between innate and adaptive pulmonary immunity, which enables the infected lung to more rapidly contain infection.
true
true
true
true
true
7,464
4
DISCUSSION
1
37
[ "bib37", "bib38", "bib17", "bib39" ]
16,157,683
pmid-1673147|pmid-10722626|pmid-12417590|pmid-12023369
Although IL-12 p35 was not required for the pulmonary IL-17 response to K. pneumoniae, it was requisite for IFN-γ expression in this infection.
[ "37", "38", "17", "39" ]
143
43,111
0
false
Although IL-12 p35 was not required for the pulmonary IL-17 response to K. pneumoniae, it was requisite for IFN-γ expression in this infection.
[]
Although IL-12 p35 was not required for the pulmonary IL-17 response to K. pneumoniae, it was requisite for IFN-γ expression in this infection.
true
true
true
true
true
7,465
4
DISCUSSION
1
37
[ "bib37", "bib38", "bib17", "bib39" ]
16,157,683
pmid-1673147|pmid-10722626|pmid-12417590|pmid-12023369
This finding is consistent with the well-studied stimulatory effect of IL-12 on IFN-γ expression (37) as well as prior work that demonstrates the requirement of intact IL-12 for the pulmonary IFN-γ response to infection (38).
[ "37", "38", "17", "39" ]
225
43,112
1
false
This finding is consistent with the well-studied stimulatory effect of IL-12 on IFN-γ expression as well as prior work that demonstrates the requirement of intact IL-12 for the pulmonary IFN-γ response to infection.
[ "37", "38" ]
This finding is consistent with the well-studied stimulatory effect of IL-12 on IFN-γ expression as well as prior work that demonstrates the requirement of intact IL-12 for the pulmonary IFN-γ response to infection.
true
true
true
true
true
7,465
4
DISCUSSION
1
17
[ "bib37", "bib38", "bib17", "bib39" ]
16,157,683
pmid-1673147|pmid-10722626|pmid-12417590|pmid-12023369
The inability of IL-23 to induce pulmonary IFN-γ expression in the absence of IL-12 is consistent with previous work showing the failure of recombinant IL-23 to induce splenocyte IFN-γ expression, despite up-regulation of IL-17 by this cytokine (17).
[ "37", "38", "17", "39" ]
250
43,113
1
false
The inability of IL-23 to induce pulmonary IFN-γ expression in the absence of IL-12 is consistent with previous work showing the failure of recombinant IL-23 to induce splenocyte IFN-γ expression, despite up-regulation of IL-17 by this cytokine.
[ "17" ]
The inability of IL-23 to induce pulmonary IFN-γ expression in the absence of IL-12 is consistent with previous work showing the failure of recombinant IL-23 to induce splenocyte IFN-γ expression, despite up-regulation of IL-17 by this cytokine.
true
true
true
true
true
7,465
4
DISCUSSION
1
37
[ "bib37", "bib38", "bib17", "bib39" ]
16,157,683
pmid-1673147|pmid-10722626|pmid-12417590|pmid-12023369
These observations are likely the result of differential receptor affinity and intracellular signaling events induced by IL-12 and IL-23.
[ "37", "38", "17", "39" ]
137
43,114
0
false
These observations are likely the result of differential receptor affinity and intracellular signaling events induced by IL-12 and IL-23.
[]
These observations are likely the result of differential receptor affinity and intracellular signaling events induced by IL-12 and IL-23.
true
true
true
true
true
7,465
4
DISCUSSION
1
37
[ "bib37", "bib38", "bib17", "bib39" ]
16,157,683
pmid-1673147|pmid-10722626|pmid-12417590|pmid-12023369
IL-12 binding to the IL-12Rβ1/Rβ2 complex predominantly activates STAT4.
[ "37", "38", "17", "39" ]
72
43,115
0
false
IL-12 binding to the IL-12Rβ1/Rβ2 complex predominantly activates STAT4.
[]
IL-12 binding to the IL-12Rβ1/Rβ2 complex predominantly activates STAT4.
true
true
true
true
true
7,465
4
DISCUSSION
1
39
[ "bib37", "bib38", "bib17", "bib39" ]
16,157,683
pmid-1673147|pmid-10722626|pmid-12417590|pmid-12023369
In contrast, IL-23 binds to the IL-23R/IL-12Rβ1 complex and induces STAT3, STAT1, and possibly STAT3/STAT4 heterodimer nuclear translocation, while only weakly activating STAT4 (39).
[ "37", "38", "17", "39" ]
182
43,116
1
false
In contrast, IL-23 binds to the IL-23R/IL-12Rβ1 complex and induces STAT3, STAT1, and possibly STAT3/STAT4 heterodimer nuclear translocation, while only weakly activating STAT4.
[ "39" ]
In contrast, IL-23 binds to the IL-23R/IL-12Rβ1 complex and induces STAT3, STAT1, and possibly STAT3/STAT4 heterodimer nuclear translocation, while only weakly activating STAT4.
true
true
true
true
true
7,465
5
DISCUSSION
0
null
null
16,157,683
null
Our finding of decreased survival following pulmonary K. pneumoniae infection in both p35−/− and p40−/− mice is consistent with other reports of the importance of intact IL-12 signaling in this infection model.
null
210
43,117
0
false
null
null
Our finding of decreased survival following pulmonary K. pneumoniae infection in both p35−/− and p40−/− mice is consistent with other reports of the importance of intact IL-12 signaling in this infection model.
true
true
true
true
true
7,466
5
DISCUSSION
0
null
null
16,157,683
null
The early and universal mortality observed in the p40−/− group compared with other strains suggests roles for both IL-12 and IL-23 in host defense.
null
147
43,118
0
false
null
null
The early and universal mortality observed in the p40−/− group compared with other strains suggests roles for both IL-12 and IL-23 in host defense.
true
true
true
true
true
7,466