Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
paragraph_index
int64
sec
string
p_has_citation
int64
cites
string
citeids
list
pmid
int64
cited_id
string
sentences
string
all_sent_cites
list
sent_len
int64
sentence_batch_index
int64
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float64
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bool
cited_sentence
string
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string
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bool
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cit_qc
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lgtm
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__index_level_0__
int64
3
DISCUSSION
1
7
[ "B7", "B41", "B47", "B53" ]
18,025,046
pmid-9169405|pmid-15033900|pmid-16698799|pmid-12138209
Our data also suggested that nucleolin binds to GC-rich elements.
[ "7", "41", "47", "53" ]
65
43,219
0
false
Our data also suggested that nucleolin binds to GC-rich elements.
[]
Our data also suggested that nucleolin binds to GC-rich elements.
true
true
true
true
true
7,479
3
DISCUSSION
1
7
[ "B7", "B41", "B47", "B53" ]
18,025,046
pmid-9169405|pmid-15033900|pmid-16698799|pmid-12138209
It is likely that nucleolin binding at place of Sp1-binding sequences could also mediate the expression of c-Jun/Sp1-activated genes.
[ "7", "41", "47", "53" ]
133
43,220
0
false
It is likely that nucleolin binding at place of Sp1-binding sequences could also mediate the expression of c-Jun/Sp1-activated genes.
[]
It is likely that nucleolin binding at place of Sp1-binding sequences could also mediate the expression of c-Jun/Sp1-activated genes.
true
true
true
true
true
7,479
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5 B6 B7", "B8" ]
18,632,762
pmid-10973918|pmid-908338|pmid-12897851|pmid-16006555|pmid-12575995|pmid-15465317|pmid-15738986|pmid-17513371
H1 linker histones are involved in chromatin structure and gene regulation (1).
[ "1", "2", "3", "4", "5–7", "8" ]
79
43,221
1
false
H1 linker histones are involved in chromatin structure and gene regulation.
[ "1" ]
H1 linker histones are involved in chromatin structure and gene regulation.
true
true
true
true
true
7,480
0
INTRODUCTION
1
2
[ "B1", "B2", "B3", "B4", "B5 B6 B7", "B8" ]
18,632,762
pmid-10973918|pmid-908338|pmid-12897851|pmid-16006555|pmid-12575995|pmid-15465317|pmid-15738986|pmid-17513371
Histone H1 contains three distinct domains: a short amino-terminal domain (20βˆ’35 amino acids), a central globular domain (∼70 amino acids) and a long carboxy-terminal domain (CTD) (∼100 amino acids) (2).
[ "1", "2", "3", "4", "5–7", "8" ]
203
43,222
1
false
Histone H1 contains three distinct domains: a short amino-terminal domain, a central globular domain (∼70 amino acids) and a long carboxy-terminal domain (CTD).
[ "20βˆ’35 amino acids", "∼100 amino acids", "2" ]
Histone H1 contains three distinct domains: a short amino-terminal domain, a central globular domain (∼70 amino acids) and a long carboxy-terminal domain (CTD).
true
true
true
true
true
7,480
0
INTRODUCTION
1
3
[ "B1", "B2", "B3", "B4", "B5 B6 B7", "B8" ]
18,632,762
pmid-10973918|pmid-908338|pmid-12897851|pmid-16006555|pmid-12575995|pmid-15465317|pmid-15738986|pmid-17513371
Several studies indicate that the ability of linker histones to stabilize chromatin folding resides in the CTD of the molecule (3).
[ "1", "2", "3", "4", "5–7", "8" ]
131
43,223
1
false
Several studies indicate that the ability of linker histones to stabilize chromatin folding resides in the CTD of the molecule.
[ "3" ]
Several studies indicate that the ability of linker histones to stabilize chromatin folding resides in the CTD of the molecule.
true
true
true
true
true
7,480
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5 B6 B7", "B8" ]
18,632,762
pmid-10973918|pmid-908338|pmid-12897851|pmid-16006555|pmid-12575995|pmid-15465317|pmid-15738986|pmid-17513371
The CTD displays a high degree of conformational flexibility.
[ "1", "2", "3", "4", "5–7", "8" ]
61
43,224
0
false
The CTD displays a high degree of conformational flexibility.
[]
The CTD displays a high degree of conformational flexibility.
true
true
true
true
true
7,480
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4", "B5 B6 B7", "B8" ]
18,632,762
pmid-10973918|pmid-908338|pmid-12897851|pmid-16006555|pmid-12575995|pmid-15465317|pmid-15738986|pmid-17513371
In aqueous solution, the CTD is dominated by the random coil and turn-like conformations in rapid equilibrium with the unfolded state, but when it interacts with DNA it folds cooperatively.
[ "1", "2", "3", "4", "5–7", "8" ]
189
43,225
0
false
In aqueous solution, the CTD is dominated by the random coil and turn-like conformations in rapid equilibrium with the unfolded state, but when it interacts with DNA it folds cooperatively.
[]
In aqueous solution, the CTD is dominated by the random coil and turn-like conformations in rapid equilibrium with the unfolded state, but when it interacts with DNA it folds cooperatively.
true
true
true
true
true
7,480
0
INTRODUCTION
1
4
[ "B1", "B2", "B3", "B4", "B5 B6 B7", "B8" ]
18,632,762
pmid-10973918|pmid-908338|pmid-12897851|pmid-16006555|pmid-12575995|pmid-15465317|pmid-15738986|pmid-17513371
The DNA-bound structure is extremely stable and includes Ξ±-helix, Ξ²-sheet, turns and open loops (flexible regions) (4).
[ "1", "2", "3", "4", "5–7", "8" ]
119
43,226
1
false
The DNA-bound structure is extremely stable and includes Ξ±-helix, Ξ²-sheet, turns and open loops (flexible regions).
[ "4" ]
The DNA-bound structure is extremely stable and includes Ξ±-helix, Ξ²-sheet, turns and open loops (flexible regions).
true
true
true
true
true
7,480
0
INTRODUCTION
1
5–7
[ "B1", "B2", "B3", "B4", "B5 B6 B7", "B8" ]
18,632,762
pmid-10973918|pmid-908338|pmid-12897851|pmid-16006555|pmid-12575995|pmid-15465317|pmid-15738986|pmid-17513371
The H1 CTD thus appears to belong to the so-called intrinsically disordered proteins undergoing coupled binding and folding (5–7).
[ "1", "2", "3", "4", "5–7", "8" ]
130
43,227
1
false
The H1 CTD thus appears to belong to the so-called intrinsically disordered proteins undergoing coupled binding and folding.
[ "5–7" ]
The H1 CTD thus appears to belong to the so-called intrinsically disordered proteins undergoing coupled binding and folding.
true
true
true
true
true
7,480
0
INTRODUCTION
1
8
[ "B1", "B2", "B3", "B4", "B5 B6 B7", "B8" ]
18,632,762
pmid-10973918|pmid-908338|pmid-12897851|pmid-16006555|pmid-12575995|pmid-15465317|pmid-15738986|pmid-17513371
In addition, in the presence of macromolecular crowding agents the unbound CTD acquires the properties of a molten globule with native-like secondary structure and compaction (8).
[ "1", "2", "3", "4", "5–7", "8" ]
179
43,228
1
false
In addition, in the presence of macromolecular crowding agents the unbound CTD acquires the properties of a molten globule with native-like secondary structure and compaction.
[ "8" ]
In addition, in the presence of macromolecular crowding agents the unbound CTD acquires the properties of a molten globule with native-like secondary structure and compaction.
true
true
true
true
true
7,480
1
INTRODUCTION
1
9
[ "B9", "B10", "B11", "B12" ]
18,632,762
pmid-9374852|pmid-8639656|pmid-4570762|pmid-16377619|pmid-14744440|pmid-11604397|pmid-16854430
The phenotypic roles of histone H1 may be determined by complementary and overlapping effects of stoichiometry, subtype composition and post-translational modifications.
[ "9", "10", "11", "12" ]
169
43,229
0
false
The phenotypic roles of histone H1 may be determined by complementary and overlapping effects of stoichiometry, subtype composition and post-translational modifications.
[]
The phenotypic roles of histone H1 may be determined by complementary and overlapping effects of stoichiometry, subtype composition and post-translational modifications.
true
true
true
true
true
7,481
1
INTRODUCTION
1
9
[ "B9", "B10", "B11", "B12" ]
18,632,762
pmid-9374852|pmid-8639656|pmid-4570762|pmid-16377619|pmid-14744440|pmid-11604397|pmid-16854430
Phosphorylation of the consensus sequences of cyclin-dependent kinases (CDKs), (S/T)-P-X-(K/R), is the main post-translational modification affecting histone H1 (9).
[ "9", "10", "11", "12" ]
165
43,230
1
false
Phosphorylation of the consensus sequences of cyclin-dependent kinases (CDKs), (S/T)-P-X-(K/R), is the main post-translational modification affecting histone H1.
[ "9" ]
Phosphorylation of the consensus sequences of cyclin-dependent kinases (CDKs), (S/T)-P-X-(K/R), is the main post-translational modification affecting histone H1.
true
true
true
true
true
7,481
1
INTRODUCTION
1
9
[ "B9", "B10", "B11", "B12" ]
18,632,762
pmid-9374852|pmid-8639656|pmid-4570762|pmid-16377619|pmid-14744440|pmid-11604397|pmid-16854430
In mammalian subtypes these sequences are localized mostly in the CTD.
[ "9", "10", "11", "12" ]
70
43,231
0
false
In mammalian subtypes these sequences are localized mostly in the CTD.
[]
In mammalian subtypes these sequences are localized mostly in the CTD.
true
true
true
true
true
7,481
1
INTRODUCTION
1
9
[ "B9", "B10", "B11", "B12" ]
18,632,762
pmid-9374852|pmid-8639656|pmid-4570762|pmid-16377619|pmid-14744440|pmid-11604397|pmid-16854430
The maximum number of phosphate groups often corresponds to the number of CDK sites in the molecule.
[ "9", "10", "11", "12" ]
100
43,232
0
false
The maximum number of phosphate groups often corresponds to the number of CDK sites in the molecule.
[]
The maximum number of phosphate groups often corresponds to the number of CDK sites in the molecule.
true
true
true
true
true
7,481
1
INTRODUCTION
1
9
[ "B9", "B10", "B11", "B12" ]
18,632,762
pmid-9374852|pmid-8639656|pmid-4570762|pmid-16377619|pmid-14744440|pmid-11604397|pmid-16854430
Histone H1 is phosphorylated in a cell cycle-dependent manner.
[ "9", "10", "11", "12" ]
62
43,233
0
false
Histone H1 is phosphorylated in a cell cycle-dependent manner.
[]
Histone H1 is phosphorylated in a cell cycle-dependent manner.
true
true
true
true
true
7,481
1
INTRODUCTION
1
9
[ "B9", "B10", "B11", "B12" ]
18,632,762
pmid-9374852|pmid-8639656|pmid-4570762|pmid-16377619|pmid-14744440|pmid-11604397|pmid-16854430
The levels of phosphorylation are lowest in G1 and rise during S and G2 (10,11).
[ "9", "10", "11", "12" ]
80
43,234
0
false
The levels of phosphorylation are lowest in G1 and rise during S and G2.
[ "10,11" ]
The levels of phosphorylation are lowest in G1 and rise during S and G2.
true
true
true
true
true
7,481
1
INTRODUCTION
1
9
[ "B9", "B10", "B11", "B12" ]
18,632,762
pmid-9374852|pmid-8639656|pmid-4570762|pmid-16377619|pmid-14744440|pmid-11604397|pmid-16854430
During interphase, H1 subtypes are present as a mixture of unphosphorylated and low-phosphorylated species with a proportion of 35–75% of unphosphorylated forms, according to the particular subtype and cell line and the moment of the cell cycle.
[ "9", "10", "11", "12" ]
245
43,235
0
false
During interphase, H1 subtypes are present as a mixture of unphosphorylated and low-phosphorylated species with a proportion of 35–75% of unphosphorylated forms, according to the particular subtype and cell line and the moment of the cell cycle.
[]
During interphase, H1 subtypes are present as a mixture of unphosphorylated and low-phosphorylated species with a proportion of 35–75% of unphosphorylated forms, according to the particular subtype and cell line and the moment of the cell cycle.
true
true
true
true
true
7,481
1
INTRODUCTION
1
9
[ "B9", "B10", "B11", "B12" ]
18,632,762
pmid-9374852|pmid-8639656|pmid-4570762|pmid-16377619|pmid-14744440|pmid-11604397|pmid-16854430
The highest number of phosphorylated sites is found in mitosis, when chromatin is maximally condensed.
[ "9", "10", "11", "12" ]
102
43,236
0
false
The highest number of phosphorylated sites is found in mitosis, when chromatin is maximally condensed.
[]
The highest number of phosphorylated sites is found in mitosis, when chromatin is maximally condensed.
true
true
true
true
true
7,481
1
INTRODUCTION
1
12
[ "B9", "B10", "B11", "B12" ]
18,632,762
pmid-9374852|pmid-8639656|pmid-4570762|pmid-16377619|pmid-14744440|pmid-11604397|pmid-16854430
Phosphorylation of H1 variants may occur site-specifically during the phases of the cell cycle (12).
[ "9", "10", "11", "12" ]
100
43,237
1
false
Phosphorylation of H1 variants may occur site-specifically during the phases of the cell cycle.
[ "12" ]
Phosphorylation of H1 variants may occur site-specifically during the phases of the cell cycle.
true
true
true
true
true
7,481
2
INTRODUCTION
1
13–15
[ "B13 B14 B15", "B16" ]
18,632,762
pmid-1412698|pmid-14612406|pmid-11130728|pmid-8144543
It is not clear how H1 phosphorylation affects chromatin condensation during interphase and mitosis.
[ "13–15", "16" ]
100
43,238
0
false
It is not clear how H1 phosphorylation affects chromatin condensation during interphase and mitosis.
[]
It is not clear how H1 phosphorylation affects chromatin condensation during interphase and mitosis.
true
true
true
true
true
7,482
2
INTRODUCTION
1
13–15
[ "B13 B14 B15", "B16" ]
18,632,762
pmid-1412698|pmid-14612406|pmid-11130728|pmid-8144543
A number of studies indicate that interphase phosphorylation is involved in chromatin relaxation (13–15); however, in metaphase chromosomes, H1 is hyperphosphorylated, and it has been shown that H1 hyperphosphorylation is required to maintain metaphase chromosomes in their condensed state (16).
[ "13–15", "16" ]
295
43,239
1
false
A number of studies indicate that interphase phosphorylation is involved in chromatin relaxation ; however, in metaphase chromosomes, H1 is hyperphosphorylated, and it has been shown that H1 hyperphosphorylation is required to maintain metaphase chromosomes in their condensed state.
[ "13–15", "16" ]
A number of studies indicate that interphase phosphorylation is involved in chromatin relaxation ; however, in metaphase chromosomes, H1 is hyperphosphorylated, and it has been shown that H1 hyperphosphorylation is required to maintain metaphase chromosomes in their condensed state.
true
true
true
true
true
7,482
3
INTRODUCTION
0
null
null
18,632,762
null
Here we report the effects of partial and full phosphorylation on the secondary structure of the CTD of histone H1 using IR spectroscopy.
null
137
43,240
0
false
null
null
Here we report the effects of partial and full phosphorylation on the secondary structure of the CTD of histone H1 using IR spectroscopy.
true
true
true
true
true
7,483
3
INTRODUCTION
0
null
null
18,632,762
null
We have also estimated the relative affinities for the DNA and the DNA condensing capacity of the different phosphorylated species of the CTD.
null
142
43,241
0
false
null
null
We have also estimated the relative affinities for the DNA and the DNA condensing capacity of the different phosphorylated species of the CTD.
true
true
true
true
true
7,483
3
INTRODUCTION
0
null
null
18,632,762
null
The results, showing site-specific effects depending on the number and position of phosphate groups may contribute to reconcile the roles of H1 phosphorylation in interphase and mitosis.
null
186
43,242
0
false
null
null
The results, showing site-specific effects depending on the number and position of phosphate groups may contribute to reconcile the roles of H1 phosphorylation in interphase and mitosis.
true
true
true
true
true
7,483
0
DISCUSSION
0
null
null
18,632,762
pmid-10973918|pmid-908338|pmid-12897851|pmid-16006555|pmid-12575995|pmid-15465317|pmid-15738986|pmid-17513371
We have shown that full phosphorylation of the DNA-bound CTD brings about a large structural change consisting in a significant increase in Ξ²-structure accompanied by a decrease in Ξ±-helix.
null
189
43,243
0
false
null
null
We have shown that full phosphorylation of the DNA-bound CTD brings about a large structural change consisting in a significant increase in Ξ²-structure accompanied by a decrease in Ξ±-helix.
true
true
true
true
true
7,484
0
DISCUSSION
0
null
null
18,632,762
pmid-10973918|pmid-908338|pmid-12897851|pmid-16006555|pmid-12575995|pmid-15465317|pmid-15738986|pmid-17513371
The effect is apparent at the lowest r values (r = 0.15), but is favored by the saturation of the DNA lattice, suggesting that protein-protein interactions contribute to the conformational transition.
null
200
43,244
0
false
null
null
The effect is apparent at the lowest r values (r = 0.15), but is favored by the saturation of the DNA lattice, suggesting that protein-protein interactions contribute to the conformational transition.
true
true
true
true
true
7,484
0
DISCUSSION
0
null
null
18,632,762
pmid-10973918|pmid-908338|pmid-12897851|pmid-16006555|pmid-12575995|pmid-15465317|pmid-15738986|pmid-17513371
Partial phosphorylation induces in general a large proportion of undefined structure (random coil and flexible regions), but, in contrast to full phosphorylation, it does not lead to a significant increase in Ξ²-structure.
null
221
43,245
0
false
null
null
Partial phosphorylation induces in general a large proportion of undefined structure (random coil and flexible regions), but, in contrast to full phosphorylation, it does not lead to a significant increase in Ξ²-structure.
true
true
true
true
true
7,484
1
DISCUSSION
1
23
[ "B23", "B24", "B25" ]
18,632,762
pmid-9374852|pmid-8639656|pmid-4570762|pmid-16377619|pmid-14744440|pmid-11604397|pmid-16854430
The increase of Ξ²-sheet content and the loss of Ξ±-helical structure in the H1 CTD following full phosphorylation is a kind of structural conversion similar to that observed in amyloidogenic proteins during fibril formation (23).
[ "23", "24", "25" ]
228
43,246
1
false
The increase of Ξ²-sheet content and the loss of Ξ±-helical structure in the H1 CTD following full phosphorylation is a kind of structural conversion similar to that observed in amyloidogenic proteins during fibril formation.
[ "23" ]
The increase of Ξ²-sheet content and the loss of Ξ±-helical structure in the H1 CTD following full phosphorylation is a kind of structural conversion similar to that observed in amyloidogenic proteins during fibril formation.
true
true
true
true
true
7,485
1
DISCUSSION
1
24
[ "B23", "B24", "B25" ]
18,632,762
pmid-9374852|pmid-8639656|pmid-4570762|pmid-16377619|pmid-14744440|pmid-11604397|pmid-16854430
In prion encephalopaties, the analogy can be pushed further as it has been shown that interaction with DNA converts the Ξ±-helical cellular isoform into a Ξ²-isoform similar to that found in the fibrilar state (24).
[ "23", "24", "25" ]
213
43,247
1
false
In prion encephalopaties, the analogy can be pushed further as it has been shown that interaction with DNA converts the Ξ±-helical cellular isoform into a Ξ²-isoform similar to that found in the fibrilar state.
[ "24" ]
In prion encephalopaties, the analogy can be pushed further as it has been shown that interaction with DNA converts the Ξ±-helical cellular isoform into a Ξ²-isoform similar to that found in the fibrilar state.
true
true
true
true
true
7,485
1
DISCUSSION
1
25
[ "B23", "B24", "B25" ]
18,632,762
pmid-9374852|pmid-8639656|pmid-4570762|pmid-16377619|pmid-14744440|pmid-11604397|pmid-16854430
Furthermore, H1 has been found associated to amyloid-like fibrils (25).
[ "23", "24", "25" ]
71
43,248
1
false
Furthermore, H1 has been found associated to amyloid-like fibrils.
[ "25" ]
Furthermore, H1 has been found associated to amyloid-like fibrils.
true
true
true
true
true
7,485
2
DISCUSSION
0
null
null
18,632,762
pmid-1412698|pmid-14612406|pmid-11130728|pmid-8144543
The effects of phosphorylation on the affinity of the CTD for the DNA were moderate: a three-fold decrease for the fully phosphorylated domain and smaller effects for the mono- and diphosphorylated species.
null
206
43,249
0
false
null
null
The effects of phosphorylation on the affinity of the CTD for the DNA were moderate: a three-fold decrease for the fully phosphorylated domain and smaller effects for the mono- and diphosphorylated species.
true
true
true
true
true
7,486
2
DISCUSSION
0
null
null
18,632,762
pmid-1412698|pmid-14612406|pmid-11130728|pmid-8144543
It is interesting to note that in spite of its lower affinity for DNA, the fully phosphorylated domain showed a higher aggregation capacity of DNA fragments than the partially phosphorylated species.
null
199
43,250
0
false
null
null
It is interesting to note that in spite of its lower affinity for DNA, the fully phosphorylated domain showed a higher aggregation capacity of DNA fragments than the partially phosphorylated species.
true
true
true
true
true
7,486
2
DISCUSSION
0
null
null
18,632,762
pmid-1412698|pmid-14612406|pmid-11130728|pmid-8144543
The aggregation capacity of the fully phosphorylated species was indeed nearly as high as that of the unphosphorylated domain.
null
126
43,251
0
false
null
null
The aggregation capacity of the fully phosphorylated species was indeed nearly as high as that of the unphosphorylated domain.
true
true
true
true
true
7,486
2
DISCUSSION
0
null
null
18,632,762
pmid-1412698|pmid-14612406|pmid-11130728|pmid-8144543
The high condensing capacity of the fully phosphorylated species might have a structural basis.
null
95
43,252
0
false
null
null
The high condensing capacity of the fully phosphorylated species might have a structural basis.
true
true
true
true
true
7,486
2
DISCUSSION
0
null
null
18,632,762
pmid-1412698|pmid-14612406|pmid-11130728|pmid-8144543
A general feature of the sequences of the CTD of H1 histones is the large proportion of basic residues present as doublets: about 75% in mammalian somatic subtypes.
null
164
43,253
0
false
null
null
A general feature of the sequences of the CTD of H1 histones is the large proportion of basic residues present as doublets: about 75% in mammalian somatic subtypes.
true
true
true
true
true
7,486
2
DISCUSSION
0
null
null
18,632,762
pmid-1412698|pmid-14612406|pmid-11130728|pmid-8144543
In Ξ²-sheets, consecutive side chains project alternatively above and below the sheet-like structure.
null
100
43,254
0
false
null
null
In Ξ²-sheets, consecutive side chains project alternatively above and below the sheet-like structure.
true
true
true
true
true
7,486
2
DISCUSSION
0
null
null
18,632,762
pmid-1412698|pmid-14612406|pmid-11130728|pmid-8144543
It is likely that the abundance of Lys doublets together with the Ξ²-sheet structure generates a binding motif with two cationic surfaces, particularly in the hyperphosphorylated CTD.
null
182
43,255
0
false
null
null
It is likely that the abundance of Lys doublets together with the Ξ²-sheet structure generates a binding motif with two cationic surfaces, particularly in the hyperphosphorylated CTD.
true
true
true
true
true
7,486
2
DISCUSSION
0
null
null
18,632,762
pmid-1412698|pmid-14612406|pmid-11130728|pmid-8144543
Such a structure seems well suited to the electrostatic crosslinking of two segments of DNA.
null
92
43,256
0
false
null
null
Such a structure seems well suited to the electrostatic crosslinking of two segments of DNA.
true
true
true
true
true
7,486
3
DISCUSSION
0
null
null
18,632,762
null
The site-specificity of the effects of phosphorylation on the secondary structure and DNA condensing capacity of the CTD, together with the moderate effect of phosphorylation on the affinity for the DNA, suggest that the effects of phosphorylation are mediated by specific structural changes and are not a simple effect ...
null
338
43,257
0
false
null
null
The site-specificity of the effects of phosphorylation on the secondary structure and DNA condensing capacity of the CTD, together with the moderate effect of phosphorylation on the affinity for the DNA, suggest that the effects of phosphorylation are mediated by specific structural changes and are not a simple effect ...
true
true
true
true
true
7,487
3
DISCUSSION
0
null
null
18,632,762
null
According to this, the properties of hyperphosphorylated H1 would not represent the extreme of a continuous variation in molecular properties depending on the number of phosphates, but would be determined by the specific structures associated with full phosphorylation.
null
269
43,258
0
false
null
null
According to this, the properties of hyperphosphorylated H1 would not represent the extreme of a continuous variation in molecular properties depending on the number of phosphates, but would be determined by the specific structures associated with full phosphorylation.
true
true
true
true
true
7,487
4
DISCUSSION
0
null
null
18,632,762
null
The reasons for general H1 hyperphosphorylation in metaphase chromosomes remain unclear.
null
88
43,259
0
false
null
null
The reasons for general H1 hyperphosphorylation in metaphase chromosomes remain unclear.
true
true
true
true
true
7,488
4
DISCUSSION
0
null
null
18,632,762
null
However, the specific structural features, in particular the high Ξ²-sheet content and the higher aggregation capacity of the fully phosphorylated domain suggest that hyperphosphorylation may play a role, together with other condensing factors, in metaphase chromatin condensation.
null
280
43,260
0
false
null
null
However, the specific structural features, in particular the high Ξ²-sheet content and the higher aggregation capacity of the fully phosphorylated domain suggest that hyperphosphorylation may play a role, together with other condensing factors, in metaphase chromatin condensation.
true
true
true
true
true
7,488
4
DISCUSSION
0
null
null
18,632,762
null
Conversely, the loss of defined structure and the lower condensing capacity of some mono- and diphosphorylated species could explain the relaxing effect of partially phosphorylated H1 on chromatin structure during interphase, particularly in S phase.
null
250
43,261
0
false
null
null
Conversely, the loss of defined structure and the lower condensing capacity of some mono- and diphosphorylated species could explain the relaxing effect of partially phosphorylated H1 on chromatin structure during interphase, particularly in S phase.
true
true
true
true
true
7,488
5
DISCUSSION
1
26
[ "B26", "B27", "B28" ]
18,632,762
pmid-8628673|pmid-16458342|pmid-16762841
Some reports support the occurrence of opposite effects of moderate as opposed to full phosphorylation.
[ "26", "27", "28" ]
103
43,262
0
false
Some reports support the occurrence of opposite effects of moderate as opposed to full phosphorylation.
[]
Some reports support the occurrence of opposite effects of moderate as opposed to full phosphorylation.
true
true
true
true
true
7,489
5
DISCUSSION
1
26
[ "B26", "B27", "B28" ]
18,632,762
pmid-8628673|pmid-16458342|pmid-16762841
SV40 minichromosomes reconstituted with either unphosphorylated or hyperphosphorylated H1 were more compact and less efficient as substrate in in vitro replication compared with minichromosomes reconstituted with moderately phosphorylated H1 (26).
[ "26", "27", "28" ]
247
43,263
1
false
SV40 minichromosomes reconstituted with either unphosphorylated or hyperphosphorylated H1 were more compact and less efficient as substrate in in vitro replication compared with minichromosomes reconstituted with moderately phosphorylated H1.
[ "26" ]
SV40 minichromosomes reconstituted with either unphosphorylated or hyperphosphorylated H1 were more compact and less efficient as substrate in in vitro replication compared with minichromosomes reconstituted with moderately phosphorylated H1.
true
true
true
true
true
7,489
5
DISCUSSION
1
26
[ "B26", "B27", "B28" ]
18,632,762
pmid-8628673|pmid-16458342|pmid-16762841
It has been suggested that hyperphosphorylation of histone H1 and H3 leads to inhibition of glucocorticoid receptor-mediated chromatin remodeling and inactivation of the mouse mammary tumor virus (MMTV) promoter by preventing the association of transcription factors with the promoter in vivo.
[ "26", "27", "28" ]
293
43,264
0
false
It has been suggested that hyperphosphorylation of histone H1 and H3 leads to inhibition of glucocorticoid receptor-mediated chromatin remodeling and inactivation of the mouse mammary tumor virus (MMTV) promoter by preventing the association of transcription factors with the promoter in vivo.
[]
It has been suggested that hyperphosphorylation of histone H1 and H3 leads to inhibition of glucocorticoid receptor-mediated chromatin remodeling and inactivation of the mouse mammary tumor virus (MMTV) promoter by preventing the association of transcription factors with the promoter in vivo.
true
true
true
true
true
7,489
5
DISCUSSION
1
27
[ "B26", "B27", "B28" ]
18,632,762
pmid-8628673|pmid-16458342|pmid-16762841
In contrast, a moderate amount of H1 phosphorylation contributes significantly to the induction of transcription from the MMTV promoter (27).
[ "26", "27", "28" ]
141
43,265
1
false
In contrast, a moderate amount of H1 phosphorylation contributes significantly to the induction of transcription from the MMTV promoter.
[ "27" ]
In contrast, a moderate amount of H1 phosphorylation contributes significantly to the induction of transcription from the MMTV promoter.
true
true
true
true
true
7,489
5
DISCUSSION
1
28
[ "B26", "B27", "B28" ]
18,632,762
pmid-8628673|pmid-16458342|pmid-16762841
It has also been shown that phosphorylation of only one site within the CTD of H1b severely disrupts the interaction between H1b and the heterochromatin protein 1Ξ± (HP1Ξ±), a key component of mammalian heterochromatin (28).
[ "26", "27", "28" ]
222
43,266
1
false
It has also been shown that phosphorylation of only one site within the CTD of H1b severely disrupts the interaction between H1b and the heterochromatin protein 1Ξ± (HP1Ξ±), a key component of mammalian heterochromatin.
[ "28" ]
It has also been shown that phosphorylation of only one site within the CTD of H1b severely disrupts the interaction between H1b and the heterochromatin protein 1Ξ± (HP1Ξ±), a key component of mammalian heterochromatin.
true
true
true
true
true
7,489
6
DISCUSSION
1
29
[ "B29", "B30", "B31" ]
18,632,762
pmid-836789|NA|pmid-3204116
Chromatin condensation associated with hyperphosphorylation in metaphase chromosomes may be structurally and mechanistically distinct from other condensed chromatin states associated with unphosphorylated H1, such as those of chicken erythrocyte nuclei (29), sea urchin sperm (30), Tetrahymena macronuclei or interphase ...
[ "29", "30", "31" ]
341
43,267
1
false
Chromatin condensation associated with hyperphosphorylation in metaphase chromosomes may be structurally and mechanistically distinct from other condensed chromatin states associated with unphosphorylated H1, such as those of chicken erythrocyte nuclei, sea urchin sperm, Tetrahymena macronuclei or interphase heterochro...
[ "29", "30", "31" ]
Chromatin condensation associated with hyperphosphorylation in metaphase chromosomes may be structurally and mechanistically distinct from other condensed chromatin states associated with unphosphorylated H1, such as those of chicken erythrocyte nuclei, sea urchin sperm, Tetrahymena macronuclei or interphase heterochro...
true
true
true
true
true
7,490
6
DISCUSSION
1
29
[ "B29", "B30", "B31" ]
18,632,762
pmid-836789|NA|pmid-3204116
Figure 5 shows a schematic representation of some H1 related factors that may be involved in the transition between relaxed and condensed chromatin in different systems.
[ "29", "30", "31" ]
169
43,268
0
false
Figure 5 shows a schematic representation of some H1 related factors that may be involved in the transition between relaxed and condensed chromatin in different systems.
[]
Figure 5 shows a schematic representation of some H1 related factors that may be involved in the transition between relaxed and condensed chromatin in different systems.
true
true
true
true
true
7,490
6
DISCUSSION
1
29
[ "B29", "B30", "B31" ]
18,632,762
pmid-836789|NA|pmid-3204116
Figure 5.H1 related factors involved in the transition between relaxed and condensed chromatin.
[ "29", "30", "31" ]
95
43,269
0
false
Figure 5.H1 related factors involved in the transition between relaxed and condensed chromatin.
[]
Figure 5.H1 related factors involved in the transition between relaxed and condensed chromatin.
true
true
true
true
true
7,490
7
DISCUSSION
0
null
null
18,632,762
null
H1 related factors involved in the transition between relaxed and condensed chromatin.
null
86
43,270
0
false
null
null
H1 related factors involved in the transition between relaxed and condensed chromatin.
true
true
true
true
true
7,491
0
INTRODUCTION
1
1
[ "b1-cln_65p357", "b4-cln_65p357" ]
20,454,491
pmid-9715489|pmid-19488587|pmid-10374168|NA|NA|NA|pmid-2350281|pmid-2350281|pmid-1305012
Cataract surgery with intraocular lens (IOL) implantation is one of the most commonly performed surgical procedures around the world.1–4 Today, the main techniques are extracapsular extraction (ECCE) and phacoemulsification (PHACO).
[ "1", "4" ]
232
43,271
0
false
Cataract surgery with intraocular lens (IOL) implantation is one of the most commonly performed surgical procedures around the world.1–4 Today, the main techniques are extracapsular extraction (ECCE) and phacoemulsification (PHACO).
[]
Cataract surgery with intraocular lens (IOL) implantation is one of the most commonly performed surgical procedures around the world.1–4 Today, the main techniques are extracapsular extraction (ECCE) and phacoemulsification (PHACO).
true
true
true
true
true
7,492
1
INTRODUCTION
1
5
[ "b5-cln_65p357", "b6-cln_65p357", "b5-cln_65p357", "b7-cln_65p357", "b8-cln_65p357" ]
20,454,491
NA|pmid-12059861|NA|NA|NA
Currently, the PHACO technique is performed in most developed countries due to the possibility of rapid visual recovery and the low complication rate.5,6 Leaming et al.5 reported that 97% of U.S. ophthalmologists performed at least one PHACO procedure in 2003.
[ "5", "6", "5", "7", "8" ]
260
43,272
0
false
Currently, the PHACO technique is performed in most developed countries due to the possibility of rapid visual recovery and the low complication rate.5,6 Leaming et al.5 reported that 97% of U.S. ophthalmologists performed at least one PHACO procedure in 2003.
[]
Currently, the PHACO technique is performed in most developed countries due to the possibility of rapid visual recovery and the low complication rate.5,6 Leaming et al.5 reported that 97% of U.S. ophthalmologists performed at least one PHACO procedure in 2003.
true
true
true
true
true
7,493
1
INTRODUCTION
1
5
[ "b5-cln_65p357", "b6-cln_65p357", "b5-cln_65p357", "b7-cln_65p357", "b8-cln_65p357" ]
20,454,491
NA|pmid-12059861|NA|NA|NA
There was an increase of PHACO surgery with foldable IOL in Brazilian public hospitals from 64,761 surgeries in 2006 to 130,498 surgeries in 2007.7,8
[ "5", "6", "5", "7", "8" ]
149
43,273
0
false
There was an increase of PHACO surgery with foldable IOL in Brazilian public hospitals from 64,761 surgeries in 2006 to 130,498 surgeries in 2007.7,8
[]
There was an increase of PHACO surgery with foldable IOL in Brazilian public hospitals from 64,761 surgeries in 2006 to 130,498 surgeries in 2007.7,8
true
true
false
true
false
7,493
2
INTRODUCTION
0
null
null
20,454,491
NA|pmid-1305012
Although the Brazilian Health Care System (SUS) pays more for cataract surgery by PHACO, there are still issues related to economic advantages in implementing this procedure instead of ECCE.
null
190
43,274
0
false
null
null
Although the Brazilian Health Care System (SUS) pays more for cataract surgery by PHACO, there are still issues related to economic advantages in implementing this procedure instead of ECCE.
true
true
true
true
true
7,494
2
INTRODUCTION
0
null
null
20,454,491
NA|pmid-1305012
Considering the lack of information in peer-reviewed literature, this study was carried out to evaluate the governmental costs of cataract surgery by PHACO and ECCE techniques in the public health care system in Brazil.
null
219
43,275
0
false
null
null
Considering the lack of information in peer-reviewed literature, this study was carried out to evaluate the governmental costs of cataract surgery by PHACO and ECCE techniques in the public health care system in Brazil.
true
true
true
true
true
7,494
0
DISCUSSION
1
2
[ "b2-cln_65p357", "b7-cln_65p357", "b8-cln_65p357", "b10-cln_65p357", "b13-cln_65p357", "b13-cln_65p357", "b20-cln_65p357" ]
20,454,491
pmid-9715489|pmid-19488587|pmid-10374168|NA|NA|NA|pmid-2350281|pmid-2350281|pmid-1305012
In the past 10 years the technique used for cataract surgery has improved, with an increase in surgeries performed using the PHACO technique.2,7,8 However, its use in public health systems challenged the economic feasibility in developing countries, due to cost overrun concerns.
[ "2", "7", "8", "10", "13", "13", "20" ]
279
43,276
0
false
In the past 10 years the technique used for cataract surgery has improved, with an increase in surgeries performed using the PHACO technique.2,7,8 However, its use in public health systems challenged the economic feasibility in developing countries, due to cost overrun concerns.
[]
In the past 10 years the technique used for cataract surgery has improved, with an increase in surgeries performed using the PHACO technique.2,7,8 However, its use in public health systems challenged the economic feasibility in developing countries, due to cost overrun concerns.
true
true
true
true
true
7,495
0
DISCUSSION
1
2
[ "b2-cln_65p357", "b7-cln_65p357", "b8-cln_65p357", "b10-cln_65p357", "b13-cln_65p357", "b13-cln_65p357", "b20-cln_65p357" ]
20,454,491
pmid-9715489|pmid-19488587|pmid-10374168|NA|NA|NA|pmid-2350281|pmid-2350281|pmid-1305012
In the context of increased costs, using financial resources for this procedure could result in fewer funds being available for other needs 10–13 The use of a PHACO technique with foldable IOL implantation in the public health care systems of developing countries is not generally encouraged by the international communi...
[ "2", "7", "8", "10", "13", "13", "20" ]
429
43,277
0
false
In the context of increased costs, using financial resources for this procedure could result in fewer funds being available for other needs 10–13 The use of a PHACO technique with foldable IOL implantation in the public health care systems of developing countries is not generally encouraged by the international communi...
[]
In the context of increased costs, using financial resources for this procedure could result in fewer funds being available for other needs 10–13 The use of a PHACO technique with foldable IOL implantation in the public health care systems of developing countries is not generally encouraged by the international communi...
true
true
false
true
false
7,495
1
DISCUSSION
0
null
null
20,454,491
NA|pmid-12059861|NA|NA|NA
Since 2001, PHACO with foldable IOL implantation has been financed by the Brazilian Health Care System.
null
103
43,278
0
false
null
null
Since 2001, PHACO with foldable IOL implantation has been financed by the Brazilian Health Care System.
true
true
true
true
true
7,496
1
DISCUSSION
0
null
null
20,454,491
NA|pmid-12059861|NA|NA|NA
Because there is no research in the national literature that justifies the real economic advantage of the PHACO technique, this study was designed to analyze the economic parameters of this technique compared to ECCE.
null
217
43,279
0
false
null
null
Because there is no research in the national literature that justifies the real economic advantage of the PHACO technique, this study was designed to analyze the economic parameters of this technique compared to ECCE.
true
true
true
true
true
7,496
2
DISCUSSION
1
19
[ "b19-cln_65p357", "b20-cln_65p357" ]
20,454,491
NA|pmid-1305012
In this study, both groups were homogeneous (Table 1).
[ "19", "20" ]
54
43,280
0
false
In this study, both groups were homogeneous (Table 1).
[]
In this study, both groups were homogeneous.
true
true
true
true
true
7,497
2
DISCUSSION
1
19
[ "b19-cln_65p357", "b20-cln_65p357" ]
20,454,491
NA|pmid-1305012
Other national studies also reported similar characteristics for patients selected for cataract surgery in public hospitals.
[ "19", "20" ]
124
43,281
0
false
Other national studies also reported similar characteristics for patients selected for cataract surgery in public hospitals.
[]
Other national studies also reported similar characteristics for patients selected for cataract surgery in public hospitals.
true
true
true
true
true
7,497
2
DISCUSSION
1
19
[ "b19-cln_65p357", "b20-cln_65p357" ]
20,454,491
NA|pmid-1305012
In San Manuel, SΓ£o Paulo, Brazil, Kara-Junior et al.19 reported a cohort that was 38.5% male.
[ "19", "20" ]
93
43,282
0
false
In San Manuel, SΓ£o Paulo, Brazil, Kara-Junior et al.19 reported a cohort that was 38.5% male.
[]
In San Manuel, SΓ£o Paulo, Brazil, Kara-Junior et al.19 reported a cohort that was 38.5% male.
true
true
true
true
true
7,497
2
DISCUSSION
1
19
[ "b19-cln_65p357", "b20-cln_65p357" ]
20,454,491
NA|pmid-1305012
In Recife, Pernambuco, Brazil, Lima et al.20 observed a mean age of 68.9 years, and 30.7% of patients were male.
[ "19", "20" ]
112
43,283
0
false
In Recife, Pernambuco, Brazil, Lima et al.20 observed a mean age of 68.9 years, and 30.7% of patients were male.
[]
In Recife, Pernambuco, Brazil, Lima et al.20 observed a mean age of 68.9 years, and 30.7% of patients were male.
true
true
true
true
true
7,497
2
DISCUSSION
1
19
[ "b19-cln_65p357", "b20-cln_65p357" ]
20,454,491
NA|pmid-1305012
According to current Brazilian Institute of Geography and Statistics (IBGE) analyses, 36.0% of the population aged over 50 years was economically active.
[ "19", "20" ]
153
43,284
0
false
According to current Brazilian Institute of Geography and Statistics (IBGE) analyses, 36.0% of the population aged over 50 years was economically active.
[]
According to current Brazilian Institute of Geography and Statistics (IBGE) analyses, 36.0% of the population aged over 50 years was economically active.
true
true
true
true
true
7,497
2
DISCUSSION
1
19
[ "b19-cln_65p357", "b20-cln_65p357" ]
20,454,491
NA|pmid-1305012
While the average age of subjects in the sample of this study was over 60 years, the proportion of economically active subjects (an average of 15.21% in both groups) was probably below the national standard for that age group (Table 1).
[ "19", "20" ]
236
43,285
0
false
While the average age of subjects in the sample of this study was over 60 years, the proportion of economically active subjects (an average of 15.21% in both groups) was probably below the national standard for that age group (Table 1).
[]
While the average age of subjects in the sample of this study was over 60 years, the proportion of economically active subjects was probably below the national standard for that age group.
true
true
true
true
true
7,497
3
DISCUSSION
1
21
[ "b21-cln_65p357" ]
20,454,491
pmid-9713047
Regional differences between developed and developing countries may also influence the cost of cataract surgery.
[ "21" ]
112
43,286
0
false
Regional differences between developed and developing countries may also influence the cost of cataract surgery.
[]
Regional differences between developed and developing countries may also influence the cost of cataract surgery.
true
true
true
true
true
7,498
3
DISCUSSION
1
21
[ "b21-cln_65p357" ]
20,454,491
pmid-9713047
In a Brazilian public hospital that performed a high number of cataract surgeries, KARA-JUNIOR et al.21 estimated that the expenditures for the government were US$ 242.23 for the PHACO and US$ 155.50 for the ECCE technique, per patient.
[ "21" ]
236
43,287
0
false
In a Brazilian public hospital that performed a high number of cataract surgeries, KARA-JUNIOR et al.21 estimated that the expenditures for the government were US$ 242.23 for the PHACO and US$ 155.50 for the ECCE technique, per patient.
[]
In a Brazilian public hospital that performed a high number of cataract surgeries, KARA-JUNIOR et al.21 estimated that the expenditures for the government were US$ 242.23 for the PHACO and US$ 155.50 for the ECCE technique, per patient.
true
true
true
true
true
7,498
4
DISCUSSION
1
10
[ "b10-cln_65p357" ]
20,454,491
NA
Currently, the Brazilian Health Care System reimbursement for cataract surgery by PHACO with foldable IOL implantation is US$ 294.95 per procedure and by ECCE with PMMA IOL is US$ 193.5810 per procedure, resulting in a difference of US$ 101.37.
[ "10" ]
244
43,288
0
false
Currently, the Brazilian Health Care System reimbursement for cataract surgery by PHACO with foldable IOL implantation is US$ 294.95 per procedure and by ECCE with PMMA IOL is US$ 193.5810 per procedure, resulting in a difference of US$ 101.37.
[]
Currently, the Brazilian Health Care System reimbursement for cataract surgery by PHACO with foldable IOL implantation is US$ 294.95 per procedure and by ECCE with PMMA IOL is US$ 193.5810 per procedure, resulting in a difference of US$ 101.37.
true
true
true
true
true
7,499
5
DISCUSSION
0
null
null
20,454,491
null
For each postoperative tonometry procedure (only on the operated eye), financing was US$ 2.72, so that subjects in the PHACO group generated a cost of US$ 8.18 over an average of 3.00 postoperative return visits, while the ECCE group generated an additional cost of US$ 14.06 over an average of 5.17 return visits.
null
314
43,289
0
false
null
null
For each postoperative tonometry procedure (only on the operated eye), financing was US$ 2.72, so that subjects in the PHACO group generated a cost of US$ 8.18 over an average of 3.00 postoperative return visits, while the ECCE group generated an additional cost of US$ 14.06 over an average of 5.17 return visits.
true
true
true
true
true
7,500
5
DISCUSSION
0
null
null
20,454,491
null
Thus, for the surgery and postoperative follow-up, the Brazilian Health Care System pays US$ 303.13 for PHACO and US$ 207.64 for ECCE, resulting in a difference of US$ 95.49.
null
174
43,290
0
false
null
null
Thus, for the surgery and postoperative follow-up, the Brazilian Health Care System pays US$ 303.13 for PHACO and US$ 207.64 for ECCE, resulting in a difference of US$ 95.49.
true
true
true
true
true
7,500
6
DISCUSSION
0
null
null
20,454,491
null
The estimated average cost for Social Security due to absence from work during the postoperative period (after the initial 15 days of salary for the absent employee, which is paid by the employer) per operated patient was US$ 6.57 in the PHACO group and US$ 51.15 in the ECCE group (Tables 2 and 3).
null
299
43,291
0
false
null
null
The estimated average cost for Social Security due to absence from work during the postoperative period (after the initial 15 days of salary for the absent employee, which is paid by the employer) per operated patient was US$ 6.57 in the PHACO group and US$ 51.15 in the ECCE group (Tables 2 and 3).
true
true
true
true
true
7,501
6
DISCUSSION
0
null
null
20,454,491
null
The difference of US$ 44.58 represents the estimated additional average expenditures for each subject from the ECCE group.
null
122
43,292
0
false
null
null
The difference of US$ 44.58 represents the estimated additional average expenditures for each subject from the ECCE group.
true
true
true
true
true
7,501
6
DISCUSSION
0
null
null
20,454,491
null
This must be added to the total public costs of the surgery, even if the cost burdens fall to different payers (Ministry of Health versus Social Security).
null
155
43,293
0
false
null
null
This must be added to the total public costs of the surgery, even if the cost burdens fall to different payers (Ministry of Health versus Social Security).
true
true
true
true
true
7,501
6
DISCUSSION
0
null
null
20,454,491
null
Brazilian Health Care System expenditures for the surgery and the postoperative period were US$ 95.49 more per patient in the PHACO group than in the ECCE group.
null
161
43,294
0
false
null
null
Brazilian Health Care System expenditures for the surgery and the postoperative period were US$ 95.49 more per patient in the PHACO group than in the ECCE group.
true
true
true
true
true
7,501
6
DISCUSSION
0
null
null
20,454,491
null
Taking into account Social Security expenditures, the average difference for the total direct cost to the government between the two procedures was US$ 50.91 or approximately half of the initial difference in cost of the PHACO surgery.
null
235
43,295
0
false
null
null
Taking into account Social Security expenditures, the average difference for the total direct cost to the government between the two procedures was US$ 50.91 or approximately half of the initial difference in cost of the PHACO surgery.
true
true
true
true
true
7,501
6
DISCUSSION
0
null
null
20,454,491
null
This difference can be considered monetarily and socially justifiable when the benefits of the PHACO surgical technique are taken into account.
null
143
43,296
0
false
null
null
This difference can be considered monetarily and socially justifiable when the benefits of the PHACO surgical technique are taken into account.
true
true
true
true
true
7,501
7
DISCUSSION
0
null
null
20,454,491
null
Therefore, for each patient with a regular job who underwent cataract surgery, the total direct cost for the government was estimated at US$ 342.21 for PHACO and US$ 587.71 for ECCE, a difference of US$ 245.50 (Table 3).
null
220
43,297
0
false
null
null
Therefore, for each patient with a regular job who underwent cataract surgery, the total direct cost for the government was estimated at US$ 342.21 for PHACO and US$ 587.71 for ECCE, a difference of US$ 245.50 (Table 3).
true
true
true
true
true
7,502
7
DISCUSSION
0
null
null
20,454,491
null
Under the conditions of this study, there is a significant economic advantage in favor of PHACO, especially if the patient is economically active.
null
146
43,298
0
false
null
null
Under the conditions of this study, there is a significant economic advantage in favor of PHACO, especially if the patient is economically active.
true
true
true
true
true
7,502
7
DISCUSSION
0
null
null
20,454,491
null
One of the basic principles of economics in the public health care system is to adopt rational measures that will provide cost savings without having a negative impact on health.
null
178
43,299
0
false
null
null
One of the basic principles of economics in the public health care system is to adopt rational measures that will provide cost savings without having a negative impact on health.
true
true
true
true
true
7,502
7
DISCUSSION
0
null
null
20,454,491
null
Thus, to introduce a novel procedure, it is essential to analyze the efficiency.
null
80
43,300
0
false
null
null
Thus, to introduce a novel procedure, it is essential to analyze the efficiency.
true
true
true
true
true
7,502
7
DISCUSSION
0
null
null
20,454,491
null
Efficiency is measured by the improvement in quality of life taking into account the economic impact of the technique on the health care system.
null
144
43,301
0
false
null
null
Efficiency is measured by the improvement in quality of life taking into account the economic impact of the technique on the health care system.
true
true
true
true
true
7,502
7
DISCUSSION
0
null
null
20,454,491
null
In conclusion, we consider that PHACO is an efficient procedure in Brazil with regard to its impact on the public health care system when all costs are assessed.
null
161
43,302
0
false
null
null
In conclusion, we consider that PHACO is an efficient procedure in Brazil with regard to its impact on the public health care system when all costs are assessed.
true
true
true
true
true
7,502
7
DISCUSSION
0
null
null
20,454,491
null
These findings provide important information for Brazilian health policy officials.
null
83
43,303
0
false
null
null
These findings provide important information for Brazilian health policy officials.
true
true
true
true
true
7,502
7
DISCUSSION
0
null
null
20,454,491
null
The entities responsible for planning public health expenditures must reconcile the strong demand for medical care with the limited resources available for financing purposes.
null
175
43,304
0
false
null
null
The entities responsible for planning public health expenditures must reconcile the strong demand for medical care with the limited resources available for financing purposes.
true
true
true
true
true
7,502
0
INTRODUCTION
1
1–4
[ "B1 B2 B3 B4", "B5 B6 B7", "B8", "B9", "B10", "B11", "B12", "B2", "B3", "B6", "B6" ]
20,378,712
pmid-15866937|pmid-9211896|pmid-12694612|pmid-16980588|pmid-8393005|pmid-17383221|pmid-11298291|pmid-12067347|pmid-19619561|pmid-7751274|pmid-12867454|pmid-15916613|pmid-9211896|pmid-12694612|pmid-17383221|pmid-17383221|pmid-17383221|pmid-18047567|pmid-17704818|pmid-19385727|pmid-8932714|pmid-14617170|pmid-14651608|pmi...
The Csr (carbon storage regulator) global regulatory system of Escherichia coli comprises four components.
[ "1–4", "5–7", "8", "9", "10", "11", "12", "2", "3", "6", "6" ]
106
43,305
0
false
The Csr (carbon storage regulator) global regulatory system of Escherichia coli comprises four components.
[]
The Csr (carbon storage regulator) global regulatory system of Escherichia coli comprises four components.
true
true
true
true
true
7,503
0
INTRODUCTION
1
1–4
[ "B1 B2 B3 B4", "B5 B6 B7", "B8", "B9", "B10", "B11", "B12", "B2", "B3", "B6", "B6" ]
20,378,712
pmid-15866937|pmid-9211896|pmid-12694612|pmid-16980588|pmid-8393005|pmid-17383221|pmid-11298291|pmid-12067347|pmid-19619561|pmid-7751274|pmid-12867454|pmid-15916613|pmid-9211896|pmid-12694612|pmid-17383221|pmid-17383221|pmid-17383221|pmid-18047567|pmid-17704818|pmid-19385727|pmid-8932714|pmid-14617170|pmid-14651608|pmi...
CsrA is a homodimeric RNA-binding protein containing two binding surfaces per dimer.
[ "1–4", "5–7", "8", "9", "10", "11", "12", "2", "3", "6", "6" ]
84
43,306
0
false
CsrA is a homodimeric RNA-binding protein containing two binding surfaces per dimer.
[]
CsrA is a homodimeric RNA-binding protein containing two binding surfaces per dimer.
true
true
true
true
true
7,503
0
INTRODUCTION
1
1–4
[ "B1 B2 B3 B4", "B5 B6 B7", "B8", "B9", "B10", "B11", "B12", "B2", "B3", "B6", "B6" ]
20,378,712
pmid-15866937|pmid-9211896|pmid-12694612|pmid-16980588|pmid-8393005|pmid-17383221|pmid-11298291|pmid-12067347|pmid-19619561|pmid-7751274|pmid-12867454|pmid-15916613|pmid-9211896|pmid-12694612|pmid-17383221|pmid-17383221|pmid-17383221|pmid-18047567|pmid-17704818|pmid-19385727|pmid-8932714|pmid-14617170|pmid-14651608|pmi...
Two non-coding small RNAs (CsrB and CsrC) antagonize CsrA activity by binding to and sequestering this protein.
[ "1–4", "5–7", "8", "9", "10", "11", "12", "2", "3", "6", "6" ]
111
43,307
0
false
Two non-coding small RNAs (CsrB and CsrC) antagonize CsrA activity by binding to and sequestering this protein.
[]
Two non-coding small RNAs (CsrB and CsrC) antagonize CsrA activity by binding to and sequestering this protein.
true
true
true
true
true
7,503
0
INTRODUCTION
1
1–4
[ "B1 B2 B3 B4", "B5 B6 B7", "B8", "B9", "B10", "B11", "B12", "B2", "B3", "B6", "B6" ]
20,378,712
pmid-15866937|pmid-9211896|pmid-12694612|pmid-16980588|pmid-8393005|pmid-17383221|pmid-11298291|pmid-12067347|pmid-19619561|pmid-7751274|pmid-12867454|pmid-15916613|pmid-9211896|pmid-12694612|pmid-17383221|pmid-17383221|pmid-17383221|pmid-18047567|pmid-17704818|pmid-19385727|pmid-8932714|pmid-14617170|pmid-14651608|pmi...
CsrD is a GGDEF-EAL domain protein that targets CsrB and CsrC for degradation by RNase E (1–4).
[ "1–4", "5–7", "8", "9", "10", "11", "12", "2", "3", "6", "6" ]
95
43,308
1
false
CsrD is a GGDEF-EAL domain protein that targets CsrB and CsrC for degradation by RNase E.
[ "1–4" ]
CsrD is a GGDEF-EAL domain protein that targets CsrB and CsrC for degradation by RNase E.
true
true
true
true
true
7,503
0
INTRODUCTION
1
5–7
[ "B1 B2 B3 B4", "B5 B6 B7", "B8", "B9", "B10", "B11", "B12", "B2", "B3", "B6", "B6" ]
20,378,712
pmid-15866937|pmid-9211896|pmid-12694612|pmid-16980588|pmid-8393005|pmid-17383221|pmid-11298291|pmid-12067347|pmid-19619561|pmid-7751274|pmid-12867454|pmid-15916613|pmid-9211896|pmid-12694612|pmid-17383221|pmid-17383221|pmid-17383221|pmid-18047567|pmid-17704818|pmid-19385727|pmid-8932714|pmid-14617170|pmid-14651608|pmi...
CsrA was identified as a repressor of glycogen metabolism, and mediates posttranscriptional repression or activation of bacterial gene expression (5–7).
[ "1–4", "5–7", "8", "9", "10", "11", "12", "2", "3", "6", "6" ]
152
43,309
1
false
CsrA was identified as a repressor of glycogen metabolism, and mediates posttranscriptional repression or activation of bacterial gene expression.
[ "5–7" ]
CsrA was identified as a repressor of glycogen metabolism, and mediates posttranscriptional repression or activation of bacterial gene expression.
true
true
true
true
true
7,503
0
INTRODUCTION
1
8
[ "B1 B2 B3 B4", "B5 B6 B7", "B8", "B9", "B10", "B11", "B12", "B2", "B3", "B6", "B6" ]
20,378,712
pmid-15866937|pmid-9211896|pmid-12694612|pmid-16980588|pmid-8393005|pmid-17383221|pmid-11298291|pmid-12067347|pmid-19619561|pmid-7751274|pmid-12867454|pmid-15916613|pmid-9211896|pmid-12694612|pmid-17383221|pmid-17383221|pmid-17383221|pmid-18047567|pmid-17704818|pmid-19385727|pmid-8932714|pmid-14617170|pmid-14651608|pmi...
The mechanism by which CsrA negatively regulates glgC, encoding a glycogen biosynthetic enzyme, has been well documented (8).
[ "1–4", "5–7", "8", "9", "10", "11", "12", "2", "3", "6", "6" ]
125
43,310
1
false
The mechanism by which CsrA negatively regulates glgC, encoding a glycogen biosynthetic enzyme, has been well documented.
[ "8" ]
The mechanism by which CsrA negatively regulates glgC, encoding a glycogen biosynthetic enzyme, has been well documented.
true
true
true
true
true
7,503
0
INTRODUCTION
1
1–4
[ "B1 B2 B3 B4", "B5 B6 B7", "B8", "B9", "B10", "B11", "B12", "B2", "B3", "B6", "B6" ]
20,378,712
pmid-15866937|pmid-9211896|pmid-12694612|pmid-16980588|pmid-8393005|pmid-17383221|pmid-11298291|pmid-12067347|pmid-19619561|pmid-7751274|pmid-12867454|pmid-15916613|pmid-9211896|pmid-12694612|pmid-17383221|pmid-17383221|pmid-17383221|pmid-18047567|pmid-17704818|pmid-19385727|pmid-8932714|pmid-14617170|pmid-14651608|pmi...
CsrA binds to the untranslated leader of the glgCAP message at two primary sites, one of which overlaps the glgC Shine–Dalgarno (SD) sequence and prevents ribosome binding.
[ "1–4", "5–7", "8", "9", "10", "11", "12", "2", "3", "6", "6" ]
172
43,311
0
false
CsrA binds to the untranslated leader of the glgCAP message at two primary sites, one of which overlaps the glgC Shine–Dalgarno (SD) sequence and prevents ribosome binding.
[]
CsrA binds to the untranslated leader of the glgCAP message at two primary sites, one of which overlaps the glgC Shine–Dalgarno (SD) sequence and prevents ribosome binding.
true
true
true
true
true
7,503
0
INTRODUCTION
1
9
[ "B1 B2 B3 B4", "B5 B6 B7", "B8", "B9", "B10", "B11", "B12", "B2", "B3", "B6", "B6" ]
20,378,712
pmid-15866937|pmid-9211896|pmid-12694612|pmid-16980588|pmid-8393005|pmid-17383221|pmid-11298291|pmid-12067347|pmid-19619561|pmid-7751274|pmid-12867454|pmid-15916613|pmid-9211896|pmid-12694612|pmid-17383221|pmid-17383221|pmid-17383221|pmid-18047567|pmid-17704818|pmid-19385727|pmid-8932714|pmid-14617170|pmid-14651608|pmi...
Binding at the second site, which is found in the loop of an RNA hairpin that lies upstream from the SD sequence, tethers CsrA to the mRNA and facilitates bridging of its remaining RNA binding surface to the SD (9).
[ "1–4", "5–7", "8", "9", "10", "11", "12", "2", "3", "6", "6" ]
215
43,312
1
false
Binding at the second site, which is found in the loop of an RNA hairpin that lies upstream from the SD sequence, tethers CsrA to the mRNA and facilitates bridging of its remaining RNA binding surface to the SD.
[ "9" ]
Binding at the second site, which is found in the loop of an RNA hairpin that lies upstream from the SD sequence, tethers CsrA to the mRNA and facilitates bridging of its remaining RNA binding surface to the SD.
true
true
true
true
true
7,503
0
INTRODUCTION
1
10
[ "B1 B2 B3 B4", "B5 B6 B7", "B8", "B9", "B10", "B11", "B12", "B2", "B3", "B6", "B6" ]
20,378,712
pmid-15866937|pmid-9211896|pmid-12694612|pmid-16980588|pmid-8393005|pmid-17383221|pmid-11298291|pmid-12067347|pmid-19619561|pmid-7751274|pmid-12867454|pmid-15916613|pmid-9211896|pmid-12694612|pmid-17383221|pmid-17383221|pmid-17383221|pmid-18047567|pmid-17704818|pmid-19385727|pmid-8932714|pmid-14617170|pmid-14651608|pmi...
Translational repression apparently leads to accelerated turnover of glgCAP mRNA and decreased expression of the glgCAP genes (10).
[ "1–4", "5–7", "8", "9", "10", "11", "12", "2", "3", "6", "6" ]
131
43,313
1
false
Translational repression apparently leads to accelerated turnover of glgCAP mRNA and decreased expression of the glgCAP genes.
[ "10" ]
Translational repression apparently leads to accelerated turnover of glgCAP mRNA and decreased expression of the glgCAP genes.
true
true
true
true
true
7,503
0
INTRODUCTION
1
1–4
[ "B1 B2 B3 B4", "B5 B6 B7", "B8", "B9", "B10", "B11", "B12", "B2", "B3", "B6", "B6" ]
20,378,712
pmid-15866937|pmid-9211896|pmid-12694612|pmid-16980588|pmid-8393005|pmid-17383221|pmid-11298291|pmid-12067347|pmid-19619561|pmid-7751274|pmid-12867454|pmid-15916613|pmid-9211896|pmid-12694612|pmid-17383221|pmid-17383221|pmid-17383221|pmid-18047567|pmid-17704818|pmid-19385727|pmid-8932714|pmid-14617170|pmid-14651608|pmi...
CsrA represses other genes and operons in a similar manner (11,12).
[ "1–4", "5–7", "8", "9", "10", "11", "12", "2", "3", "6", "6" ]
67
43,314
0
false
CsrA represses other genes and operons in a similar manner.
[ "11,12" ]
CsrA represses other genes and operons in a similar manner.
true
true
true
true
true
7,503
0
INTRODUCTION
1
1–4
[ "B1 B2 B3 B4", "B5 B6 B7", "B8", "B9", "B10", "B11", "B12", "B2", "B3", "B6", "B6" ]
20,378,712
pmid-15866937|pmid-9211896|pmid-12694612|pmid-16980588|pmid-8393005|pmid-17383221|pmid-11298291|pmid-12067347|pmid-19619561|pmid-7751274|pmid-12867454|pmid-15916613|pmid-9211896|pmid-12694612|pmid-17383221|pmid-17383221|pmid-17383221|pmid-18047567|pmid-17704818|pmid-19385727|pmid-8932714|pmid-14617170|pmid-14651608|pmi...
CsrA activity is modulated by the action of the small untranslated RNAs, CsrB and CsrC, which contain multiple copies of an imperfectly repetitive sequence element (22 in CsrB and 13 in CsrC) that serves as a CsrA binding site.
[ "1–4", "5–7", "8", "9", "10", "11", "12", "2", "3", "6", "6" ]
227
43,315
0
false
CsrA activity is modulated by the action of the small untranslated RNAs, CsrB and CsrC, which contain multiple copies of an imperfectly repetitive sequence element that serves as a CsrA binding site.
[ "22 in CsrB and 13 in CsrC" ]
CsrA activity is modulated by the action of the small untranslated RNAs, CsrB and CsrC, which contain multiple copies of an imperfectly repetitive sequence element that serves as a CsrA binding site.
true
true
true
true
true
7,503
0
INTRODUCTION
1
1–4
[ "B1 B2 B3 B4", "B5 B6 B7", "B8", "B9", "B10", "B11", "B12", "B2", "B3", "B6", "B6" ]
20,378,712
pmid-15866937|pmid-9211896|pmid-12694612|pmid-16980588|pmid-8393005|pmid-17383221|pmid-11298291|pmid-12067347|pmid-19619561|pmid-7751274|pmid-12867454|pmid-15916613|pmid-9211896|pmid-12694612|pmid-17383221|pmid-17383221|pmid-17383221|pmid-18047567|pmid-17704818|pmid-19385727|pmid-8932714|pmid-14617170|pmid-14651608|pmi...
In this way, CsrB binds to and sequesters ∼9 to 10 CsrA dimers, preventing their interaction with mRNA targets (2,3,6).
[ "1–4", "5–7", "8", "9", "10", "11", "12", "2", "3", "6", "6" ]
119
43,316
0
false
In this way, CsrB binds to and sequesters ∼9 to 10 CsrA dimers, preventing their interaction with mRNA targets.
[ "2,3,6" ]
In this way, CsrB binds to and sequesters ∼9 to 10 CsrA dimers, preventing their interaction with mRNA targets.
true
true
true
true
true
7,503
0
INTRODUCTION
1
6
[ "B1 B2 B3 B4", "B5 B6 B7", "B8", "B9", "B10", "B11", "B12", "B2", "B3", "B6", "B6" ]
20,378,712
pmid-15866937|pmid-9211896|pmid-12694612|pmid-16980588|pmid-8393005|pmid-17383221|pmid-11298291|pmid-12067347|pmid-19619561|pmid-7751274|pmid-12867454|pmid-15916613|pmid-9211896|pmid-12694612|pmid-17383221|pmid-17383221|pmid-17383221|pmid-18047567|pmid-17704818|pmid-19385727|pmid-8932714|pmid-14617170|pmid-14651608|pmi...
In a variety of species, transcription of Csr RNAs requires a conserved two component signal transduction system, which is known as BarA-UvrY in E. coli (6).
[ "1–4", "5–7", "8", "9", "10", "11", "12", "2", "3", "6", "6" ]
157
43,317
1
false
In a variety of species, transcription of Csr RNAs requires a conserved two component signal transduction system, which is known as BarA-UvrY in E. coli.
[ "6" ]
In a variety of species, transcription of Csr RNAs requires a conserved two component signal transduction system, which is known as BarA-UvrY in E. coli.
true
true
true
true
true
7,503
0
INTRODUCTION
1
1–4
[ "B1 B2 B3 B4", "B5 B6 B7", "B8", "B9", "B10", "B11", "B12", "B2", "B3", "B6", "B6" ]
20,378,712
pmid-15866937|pmid-9211896|pmid-12694612|pmid-16980588|pmid-8393005|pmid-17383221|pmid-11298291|pmid-12067347|pmid-19619561|pmid-7751274|pmid-12867454|pmid-15916613|pmid-9211896|pmid-12694612|pmid-17383221|pmid-17383221|pmid-17383221|pmid-18047567|pmid-17704818|pmid-19385727|pmid-8932714|pmid-14617170|pmid-14651608|pmi...
However, the molecular mechanisms by which environmental stimuli control the Csr global regulatory system remain elusive.
[ "1–4", "5–7", "8", "9", "10", "11", "12", "2", "3", "6", "6" ]
121
43,318
0
false
However, the molecular mechanisms by which environmental stimuli control the Csr global regulatory system remain elusive.
[]
However, the molecular mechanisms by which environmental stimuli control the Csr global regulatory system remain elusive.
true
true
true
true
true
7,503