Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
paragraph_index
int64
sec
string
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cites
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pmid
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int64
5
DISCUSSION
0
null
null
16,157,683
null
That a normally sublethal pathogen dose imparts 60% mortality in IL-23 p19−/− animals confirms the critical requirement for this cytokine in surviving pulmonary K. pneumoniae infection.
null
185
43,119
0
false
null
null
That a normally sublethal pathogen dose imparts 60% mortality in IL-23 p19−/− animals confirms the critical requirement for this cytokine in surviving pulmonary K. pneumoniae infection.
true
true
true
true
true
7,466
5
DISCUSSION
0
null
null
16,157,683
null
Bacterial clearance could be significantly enhanced in IL-23 p19−/− mice by administration of recombinant IL-17 at 12 h into the infection, and this treatment restored G-CSF and LIX production without correcting IL-6 expression.
null
228
43,120
0
false
null
null
Bacterial clearance could be significantly enhanced in IL-23 p19−/− mice by administration of recombinant IL-17 at 12 h into the infection, and this treatment restored G-CSF and LIX production without correcting IL-6 expression.
true
true
true
true
true
7,466
5
DISCUSSION
0
null
null
16,157,683
null
These data suggest that the absence of IL-17 signaling in p19−/− mice mediates the observed phenotype and that IL-17–induced IL-6 signaling is not a critical component of host defense in this infection model.
null
208
43,121
0
false
null
null
These data suggest that the absence of IL-17 signaling in p19−/− mice mediates the observed phenotype and that IL-17–induced IL-6 signaling is not a critical component of host defense in this infection model.
true
true
true
true
true
7,466
5
DISCUSSION
0
null
null
16,157,683
null
Despite the absence of IL-12 and markedly diminished lung IFN-γ induction in IL-12/23 p40−/− mice, IL-17 treatment still reduced significantly the high bacterial burden observed in these mice, further suggesting IL-17 plays a significant role in host defenses in this model independent of IL-12/IFN-γ signaling.
null
311
43,122
0
false
null
null
Despite the absence of IL-12 and markedly diminished lung IFN-γ induction in IL-12/23 p40−/− mice, IL-17 treatment still reduced significantly the high bacterial burden observed in these mice, further suggesting IL-17 plays a significant role in host defenses in this model independent of IL-12/IFN-γ signaling.
true
true
true
true
true
7,466
6
DISCUSSION
1
40
[ "bib40", "bib41", "bib43" ]
16,157,683
pmid-12077275|pmid-12624114|pmid-14720045
We recognize that the current study has important limitations.
[ "40", "41", "43" ]
62
43,123
0
false
We recognize that the current study has important limitations.
[]
We recognize that the current study has important limitations.
true
true
true
true
true
7,467
6
DISCUSSION
1
40
[ "bib40", "bib41", "bib43" ]
16,157,683
pmid-12077275|pmid-12624114|pmid-14720045
Namely, we have not identified the specific effector immune functions defective in the absence of IL-23 signaling.
[ "40", "41", "43" ]
114
43,124
0
false
Namely, we have not identified the specific effector immune functions defective in the absence of IL-23 signaling.
[]
Namely, we have not identified the specific effector immune functions defective in the absence of IL-23 signaling.
true
true
true
true
true
7,467
6
DISCUSSION
1
40
[ "bib40", "bib41", "bib43" ]
16,157,683
pmid-12077275|pmid-12624114|pmid-14720045
Because IL-17 and IL-17F elicit neutrophil recruitment in the lung (40), defects in the number or function of these cells may also underlie the observed phenotype.
[ "40", "41", "43" ]
163
43,125
1
false
Because IL-17 and IL-17F elicit neutrophil recruitment in the lung, defects in the number or function of these cells may also underlie the observed phenotype.
[ "40" ]
Because IL-17 and IL-17F elicit neutrophil recruitment in the lung, defects in the number or function of these cells may also underlie the observed phenotype.
true
true
true
true
true
7,467
6
DISCUSSION
1
40
[ "bib40", "bib41", "bib43" ]
16,157,683
pmid-12077275|pmid-12624114|pmid-14720045
Impaired antimicrobial peptide production may also contribute to enhanced mortality, as IL-17 signaling has also been shown to induce airway epithelial cell expression of mucin and β defensin 2 proteins, molecules important in bacterial clearance (41–43).
[ "40", "41", "43" ]
255
43,126
0
false
Impaired antimicrobial peptide production may also contribute to enhanced mortality, as IL-17 signaling has also been shown to induce airway epithelial cell expression of mucin and β defensin 2 proteins, molecules important in bacterial clearance.
[ "41–43" ]
Impaired antimicrobial peptide production may also contribute to enhanced mortality, as IL-17 signaling has also been shown to induce airway epithelial cell expression of mucin and β defensin 2 proteins, molecules important in bacterial clearance.
true
true
true
true
true
7,467
7
DISCUSSION
1
44
[ "bib44", "bib46", "bib47" ]
16,157,683
pmid-9206995|pmid-8245795|pmid-15657292
Our data support a critical role for IL-23 and IL-17 in early host resistance to K. pneumoniae independent of IL-12 and IFN-γ.
[ "44", "46", "47" ]
126
43,127
0
false
Our data support a critical role for IL-23 and IL-17 in early host resistance to K. pneumoniae independent of IL-12 and IFN-γ.
[]
Our data support a critical role for IL-23 and IL-17 in early host resistance to K. pneumoniae independent of IL-12 and IFN-γ.
true
true
true
true
true
7,468
7
DISCUSSION
1
44
[ "bib44", "bib46", "bib47" ]
16,157,683
pmid-9206995|pmid-8245795|pmid-15657292
It is possible that IL-23 and the subsequent IL-17 pathway have evolved to handle extracellular gram-negative bacterial challenges, because IL-17 is not required for host resistance against intracellular organisms such as Listeria monocytogenes or Mycobacterium tuberculosis (Kolls et al., unpublished observations), whe...
[ "44", "46", "47" ]
424
43,128
0
false
It is possible that IL-23 and the subsequent IL-17 pathway have evolved to handle extracellular gram-negative bacterial challenges, because IL-17 is not required for host resistance against intracellular organisms such as Listeria monocytogenes or Mycobacterium tuberculosis (Kolls et al., unpublished observations), whe...
[ "44–46" ]
It is possible that IL-23 and the subsequent IL-17 pathway have evolved to handle extracellular gram-negative bacterial challenges, because IL-17 is not required for host resistance against intracellular organisms such as Listeria monocytogenes or Mycobacterium tuberculosis (Kolls et al., unpublished observations), whe...
true
true
true
true
true
7,468
7
DISCUSSION
1
47
[ "bib44", "bib46", "bib47" ]
16,157,683
pmid-9206995|pmid-8245795|pmid-15657292
Moreover, because IL-23 is critical for autoimmune diseases such as arthritis and multiple sclerosis (47), our data suggest that targeting IL-23 p19 would be less immunosuppressive than IL-12/23 p40.
[ "44", "46", "47" ]
199
43,129
1
false
Moreover, because IL-23 is critical for autoimmune diseases such as arthritis and multiple sclerosis, our data suggest that targeting IL-23 p19 would be less immunosuppressive than IL-12/23 p40.
[ "47" ]
Moreover, because IL-23 is critical for autoimmune diseases such as arthritis and multiple sclerosis, our data suggest that targeting IL-23 p19 would be less immunosuppressive than IL-12/23 p40.
true
true
true
true
true
7,468
0
DISCUSSION
1
10
[ "B10", "B11", "B12" ]
11,752,981
pmid-8406422|pmid-1536615|pmid-2642309
Although granulosa cell tumor is the most common sexcord stromal tumor to occur in the ovary, it is extremely rare in the testis and its origin is poorly understood.
[ "10", "11", "12" ]
165
43,130
0
false
Although granulosa cell tumor is the most common sexcord stromal tumor to occur in the ovary, it is extremely rare in the testis and its origin is poorly understood.
[]
Although granulosa cell tumor is the most common sexcord stromal tumor to occur in the ovary, it is extremely rare in the testis and its origin is poorly understood.
true
true
true
true
true
7,469
0
DISCUSSION
1
10
[ "B10", "B11", "B12" ]
11,752,981
pmid-8406422|pmid-1536615|pmid-2642309
To the best of our knowledge, the literature in English is limited to only 19 cases of adult granulosa cell tumor of the testis (10).
[ "10", "11", "12" ]
133
43,131
1
false
To the best of our knowledge, the literature in English is limited to only 19 cases of adult granulosa cell tumor of the testis.
[ "10" ]
To the best of our knowledge, the literature in English is limited to only 19 cases of adult granulosa cell tumor of the testis.
true
true
true
true
true
7,469
0
DISCUSSION
1
10
[ "B10", "B11", "B12" ]
11,752,981
pmid-8406422|pmid-1536615|pmid-2642309
Moreover, the radiologic findings of this disease entity are not well known.
[ "10", "11", "12" ]
76
43,132
0
false
Moreover, the radiologic findings of this disease entity are not well known.
[]
Moreover, the radiologic findings of this disease entity are not well known.
true
true
true
true
true
7,469
0
DISCUSSION
1
10
[ "B10", "B11", "B12" ]
11,752,981
pmid-8406422|pmid-1536615|pmid-2642309
We are aware of only two previous reports of the US findings of adult-type testicular granulosa cell tumor, and both of these described the tumor as a well-defined hypoechoic testicular mass (11, 12).
[ "10", "11", "12" ]
200
43,133
0
false
We are aware of only two previous reports of the US findings of adult-type testicular granulosa cell tumor, and both of these described the tumor as a well-defined hypoechoic testicular mass.
[ "11, 12" ]
We are aware of only two previous reports of the US findings of adult-type testicular granulosa cell tumor, and both of these described the tumor as a well-defined hypoechoic testicular mass.
true
true
true
true
true
7,469
1
DISCUSSION
1
13
[ "B13", "B14", "B9" ]
11,752,981
pmid-9591732|pmid-1847943|pmid-7020914
In our case, the tumor appeared to arise from the scrotal tunics, an unusual location for a sex-cord stromal tumor.
[ "13", "14", "9" ]
115
43,134
0
false
In our case, the tumor appeared to arise from the scrotal tunics, an unusual location for a sex-cord stromal tumor.
[]
In our case, the tumor appeared to arise from the scrotal tunics, an unusual location for a sex-cord stromal tumor.
true
true
true
true
true
7,470
1
DISCUSSION
1
13
[ "B13", "B14", "B9" ]
11,752,981
pmid-9591732|pmid-1847943|pmid-7020914
It was, however, because of the presence of typical large indented nuclei with longitudinal nuclear grooves and Call-Exner bodies, as well as positive immunoreactivity for inhibin, keratin and vimentin, that granulosa cell tumor was diagnosed (13).
[ "13", "14", "9" ]
248
43,135
1
false
It was, however, because of the presence of typical large indented nuclei with longitudinal nuclear grooves and Call-Exner bodies, as well as positive immunoreactivity for inhibin, keratin and vimentin, that granulosa cell tumor was diagnosed.
[ "13" ]
It was, however, because of the presence of typical large indented nuclei with longitudinal nuclear grooves and Call-Exner bodies, as well as positive immunoreactivity for inhibin, keratin and vimentin, that granulosa cell tumor was diagnosed.
true
true
true
true
true
7,470
1
DISCUSSION
1
14
[ "B13", "B14", "B9" ]
11,752,981
pmid-9591732|pmid-1847943|pmid-7020914
Fourteen percent of all paratesticular tumors arise from the scrotal tunics and among these, benign fibroma, representing a fibrous reaction to chronic periorchitis, is the most common lesion (14).
[ "13", "14", "9" ]
197
43,136
1
false
Fourteen percent of all paratesticular tumors arise from the scrotal tunics and among these, benign fibroma, representing a fibrous reaction to chronic periorchitis, is the most common lesion.
[ "14" ]
Fourteen percent of all paratesticular tumors arise from the scrotal tunics and among these, benign fibroma, representing a fibrous reaction to chronic periorchitis, is the most common lesion.
true
true
true
true
true
7,470
1
DISCUSSION
1
9
[ "B13", "B14", "B9" ]
11,752,981
pmid-9591732|pmid-1847943|pmid-7020914
Although granulosa cell tumor arising from the scrotal tunics has not been previously reported, extratesticular sex-cord stromal tumor in the pelvis has been described (9).
[ "13", "14", "9" ]
172
43,137
1
false
Although granulosa cell tumor arising from the scrotal tunics has not been previously reported, extratesticular sex-cord stromal tumor in the pelvis has been described.
[ "9" ]
Although granulosa cell tumor arising from the scrotal tunics has not been previously reported, extratesticular sex-cord stromal tumor in the pelvis has been described.
true
true
true
true
true
7,470
1
DISCUSSION
1
13
[ "B13", "B14", "B9" ]
11,752,981
pmid-9591732|pmid-1847943|pmid-7020914
The suggested explanation is that the tumor originated in a residual part of the primitive gonad or a third undescended testis which was completely destroyed by the process, and we believe that in our case the same explanation is possible.
[ "13", "14", "9" ]
239
43,138
0
false
The suggested explanation is that the tumor originated in a residual part of the primitive gonad or a third undescended testis which was completely destroyed by the process, and we believe that in our case the same explanation is possible.
[]
The suggested explanation is that the tumor originated in a residual part of the primitive gonad or a third undescended testis which was completely destroyed by the process, and we believe that in our case the same explanation is possible.
true
true
true
true
true
7,470
2
DISCUSSION
0
null
null
11,752,981
null
Pathologic examination indicated that this tumor had originated from and was confined to the scrotal tunics.
null
108
43,139
0
false
null
null
Pathologic examination indicated that this tumor had originated from and was confined to the scrotal tunics.
true
true
true
true
true
7,471
2
DISCUSSION
0
null
null
11,752,981
null
The testis and epididymis were normal and easily separated from the tumor.
null
74
43,140
0
false
null
null
The testis and epididymis were normal and easily separated from the tumor.
true
true
true
true
true
7,471
2
DISCUSSION
0
null
null
11,752,981
null
Nevertheless, because the largest nodule was deeply invaginated into the testis, displacing the epididymis, which was compressed and not visualized, the location of this tumor - according to the findings of US and MR imaging - was intratesticular and epididymal.
null
262
43,141
0
false
null
null
Nevertheless, because the largest nodule was deeply invaginated into the testis, displacing the epididymis, which was compressed and not visualized, the location of this tumor - according to the findings of US and MR imaging - was intratesticular and epididymal.
true
true
true
true
true
7,471
2
DISCUSSION
0
null
null
11,752,981
null
It was because the main lesion was in the testis and epididymis, and multiple small nodules were attached to the inner scrotal wall, that malignancy was suspected.
null
163
43,142
0
false
null
null
It was because the main lesion was in the testis and epididymis, and multiple small nodules were attached to the inner scrotal wall, that malignancy was suspected.
true
true
true
true
true
7,471
2
DISCUSSION
0
null
null
11,752,981
null
On the other hand, because of extensive hydrocele, the lesion also mimicked an inflammatory condition such as tuberculous epididymo-orchitis.
null
141
43,143
0
false
null
null
On the other hand, because of extensive hydrocele, the lesion also mimicked an inflammatory condition such as tuberculous epididymo-orchitis.
true
true
true
true
true
7,471
2
DISCUSSION
0
null
null
11,752,981
null
The only clue to the origin of the mass was the low-signal-intensity rim between the lesion and the testis revealed by T2-weighted imaging.
null
139
43,144
0
false
null
null
The only clue to the origin of the mass was the low-signal-intensity rim between the lesion and the testis revealed by T2-weighted imaging.
true
true
true
true
true
7,471
3
DISCUSSION
0
null
null
11,752,981
null
To our knowledge, this is the first reported case of paratesticular granulosa cell tumor, and it would therefore be premature to state that the US and MR features of our case are specific to granulosa cell tumor of the scrotal tunics.
null
234
43,145
0
false
null
null
To our knowledge, this is the first reported case of paratesticular granulosa cell tumor, and it would therefore be premature to state that the US and MR features of our case are specific to granulosa cell tumor of the scrotal tunics.
true
true
true
true
true
7,472
3
DISCUSSION
0
null
null
11,752,981
null
Although the formulation of a treatment plan might not require specific diagnosis, we suggest that the presence of a mass seen as an intratesticular lesion associated with multiple enhancing nodules attached to scrotal tunics indicates the possibility of a paratesticular tumor, and that granulosa cell tumor should be i...
null
358
43,146
0
false
null
null
Although the formulation of a treatment plan might not require specific diagnosis, we suggest that the presence of a mass seen as an intratesticular lesion associated with multiple enhancing nodules attached to scrotal tunics indicates the possibility of a paratesticular tumor, and that granulosa cell tumor should be i...
true
true
true
true
true
7,472
3
DISCUSSION
0
null
null
11,752,981
null
We believe that MR imaging findings of a peripheral low-signal-intensity rim on a T2-weighted image might help determine the origin of the mass.
null
144
43,147
0
false
null
null
We believe that MR imaging findings of a peripheral low-signal-intensity rim on a T2-weighted image might help determine the origin of the mass.
true
true
true
true
true
7,472
0
INTRODUCTION
1
1–3
[ "B1 B2 B3", "B4", "B5", "B6", "B7" ]
18,025,046
pmid-12088280|pmid-15950989|pmid-15896353|pmid-11901304|pmid-3409218|pmid-3130187|pmid-9169405|pmid-9169405|pmid-9169405|pmid-15033900|pmid-16055435|pmid-15777800
The production of lipid mediators, the eicosanoids (i.e.
[ "1–3", "4", "5", "6", "7" ]
56
43,148
0
false
The production of lipid mediators, the eicosanoids (i.e.
[]
The production of lipid mediators, the eicosanoids (i.e.
true
true
true
true
true
7,473
0
INTRODUCTION
1
1–3
[ "B1 B2 B3", "B4", "B5", "B6", "B7" ]
18,025,046
pmid-12088280|pmid-15950989|pmid-15896353|pmid-11901304|pmid-3409218|pmid-3130187|pmid-9169405|pmid-9169405|pmid-9169405|pmid-15033900|pmid-16055435|pmid-15777800
prostaglandins and leukotrienes) are derived from metabolism of arachidonic acid, which has been implicated in the regulation of cell growth, inflammation, thrombosis and tumor progression (1–3).
[ "1–3", "4", "5", "6", "7" ]
195
43,149
1
false
prostaglandins and leukotrienes) are derived from metabolism of arachidonic acid, which has been implicated in the regulation of cell growth, inflammation, thrombosis and tumor progression.
[ "1–3" ]
prostaglandins and leukotrienes) are derived from metabolism of arachidonic acid, which has been implicated in the regulation of cell growth, inflammation, thrombosis and tumor progression.
false
true
true
true
false
7,473
0
INTRODUCTION
1
4
[ "B1 B2 B3", "B4", "B5", "B6", "B7" ]
18,025,046
pmid-12088280|pmid-15950989|pmid-15896353|pmid-11901304|pmid-3409218|pmid-3130187|pmid-9169405|pmid-9169405|pmid-9169405|pmid-15033900|pmid-16055435|pmid-15777800
There is much evidence indicating that eicosanoids, particularly prostaglandins, are involved in the etiologies of cancer (4).
[ "1–3", "4", "5", "6", "7" ]
126
43,150
1
false
There is much evidence indicating that eicosanoids, particularly prostaglandins, are involved in the etiologies of cancer.
[ "4" ]
There is much evidence indicating that eicosanoids, particularly prostaglandins, are involved in the etiologies of cancer.
true
true
true
true
true
7,473
0
INTRODUCTION
1
1–3
[ "B1 B2 B3", "B4", "B5", "B6", "B7" ]
18,025,046
pmid-12088280|pmid-15950989|pmid-15896353|pmid-11901304|pmid-3409218|pmid-3130187|pmid-9169405|pmid-9169405|pmid-9169405|pmid-15033900|pmid-16055435|pmid-15777800
Increased levels of eicosanoids occur in a number of different types of human cancer, including colon, pancreatic, breast and lung.
[ "1–3", "4", "5", "6", "7" ]
131
43,151
0
false
Increased levels of eicosanoids occur in a number of different types of human cancer, including colon, pancreatic, breast and lung.
[]
Increased levels of eicosanoids occur in a number of different types of human cancer, including colon, pancreatic, breast and lung.
true
true
true
true
true
7,473
0
INTRODUCTION
1
1–3
[ "B1 B2 B3", "B4", "B5", "B6", "B7" ]
18,025,046
pmid-12088280|pmid-15950989|pmid-15896353|pmid-11901304|pmid-3409218|pmid-3130187|pmid-9169405|pmid-9169405|pmid-9169405|pmid-15033900|pmid-16055435|pmid-15777800
In the case of lung cancer, increased prostaglandin biosynthesis has been found to occur mainly in non-small cell lung cancer (NSCLC), which comprises 80% of lung cancers rather than small cell lung cancer (SCLC) (5,6).
[ "1–3", "4", "5", "6", "7" ]
219
43,152
0
false
In the case of lung cancer, increased prostaglandin biosynthesis has been found to occur mainly in non-small cell lung cancer (NSCLC), which comprises 80% of lung cancers rather than small cell lung cancer (SCLC).
[ "5,6" ]
In the case of lung cancer, increased prostaglandin biosynthesis has been found to occur mainly in non-small cell lung cancer (NSCLC), which comprises 80% of lung cancers rather than small cell lung cancer (SCLC).
true
true
true
true
true
7,473
0
INTRODUCTION
1
7
[ "B1 B2 B3", "B4", "B5", "B6", "B7" ]
18,025,046
pmid-12088280|pmid-15950989|pmid-15896353|pmid-11901304|pmid-3409218|pmid-3130187|pmid-9169405|pmid-9169405|pmid-9169405|pmid-15033900|pmid-16055435|pmid-15777800
In addition, the increase of cPLA2 is correlated with the eicosanoid synthesis that participates in NSCLC transformation (7).
[ "1–3", "4", "5", "6", "7" ]
125
43,153
1
false
In addition, the increase of cPLA2 is correlated with the eicosanoid synthesis that participates in NSCLC transformation.
[ "7" ]
In addition, the increase of cPLA2 is correlated with the eicosanoid synthesis that participates in NSCLC transformation.
true
true
true
true
true
7,473
1
INTRODUCTION
1
8
[ "B8", "B9", "B10", "B11", "B12", "B13", "B14 B15 B16", "B17 B18 B19 B20 B21", "B18", "B22", "B23", "B24", "B25" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
Cytosolic phospholipase A2 (cPLA2) is the major intracellular form of PLA2, which preferentially hydrolyzes membrane phospholipids at the sn-2 position to release arachidonic acid (8).
[ "8", "9", "10", "11", "12", "13", "14–16", "17–21", "18", "22", "23", "24", "25" ]
184
43,154
1
false
Cytosolic phospholipase A2 (cPLA2) is the major intracellular form of PLA2, which preferentially hydrolyzes membrane phospholipids at the sn-2 position to release arachidonic acid.
[ "8" ]
Cytosolic phospholipase A2 (cPLA2) is the major intracellular form of PLA2, which preferentially hydrolyzes membrane phospholipids at the sn-2 position to release arachidonic acid.
true
true
true
true
true
7,474
1
INTRODUCTION
1
8
[ "B8", "B9", "B10", "B11", "B12", "B13", "B14 B15 B16", "B17 B18 B19 B20 B21", "B18", "B22", "B23", "B24", "B25" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
cPLA2 activity is regulated by intracellular Ca2+ and phosphorylation.
[ "8", "9", "10", "11", "12", "13", "14–16", "17–21", "18", "22", "23", "24", "25" ]
70
43,155
0
false
cPLA2 activity is regulated by intracellular Ca2+ and phosphorylation.
[]
cPLA2 activity is regulated by intracellular Ca2+ and phosphorylation.
false
true
true
true
false
7,474
1
INTRODUCTION
1
8
[ "B8", "B9", "B10", "B11", "B12", "B13", "B14 B15 B16", "B17 B18 B19 B20 B21", "B18", "B22", "B23", "B24", "B25" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
Increase in Ca2+ results in translocation of cPLA2 to the nuclear envelope and activation (9,10).
[ "8", "9", "10", "11", "12", "13", "14–16", "17–21", "18", "22", "23", "24", "25" ]
97
43,156
0
false
Increase in Ca2+ results in translocation of cPLA2 to the nuclear envelope and activation.
[ "9,10" ]
Increase in Ca2+ results in translocation of cPLA2 to the nuclear envelope and activation.
true
true
true
true
true
7,474
1
INTRODUCTION
1
13
[ "B8", "B9", "B10", "B11", "B12", "B13", "B14 B15 B16", "B17 B18 B19 B20 B21", "B18", "B22", "B23", "B24", "B25" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
But it has been shown that phorbol 12-myristate 13-acetate (PMA) provides cPLA2-activating signals without inducing Ca2+ influx (11,12) and by a Rac-p38 kinase-dependent pathway (13).
[ "8", "9", "10", "11", "12", "13", "14–16", "17–21", "18", "22", "23", "24", "25" ]
183
43,157
1
false
But it has been shown that phorbol 12-myristate 13-acetate (PMA) provides cPLA2-activating signals without inducing Ca2+ influx and by a Rac-p38 kinase-dependent pathway.
[ "11,12", "13" ]
But it has been shown that phorbol 12-myristate 13-acetate (PMA) provides cPLA2-activating signals without inducing Ca2+ influx and by a Rac-p38 kinase-dependent pathway.
true
true
true
true
true
7,474
1
INTRODUCTION
1
14–16
[ "B8", "B9", "B10", "B11", "B12", "B13", "B14 B15 B16", "B17 B18 B19 B20 B21", "B18", "B22", "B23", "B24", "B25" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
The maximal activation of cPLA2 requires sustained phosphorylation of Ser505, Ser727 and Ser515 by mitogen-activated protein kinases (MAPKs), MAPK-activated protein kinases and by calcium/calmodulin-dependent protein kinase II, respectively (14–16).
[ "8", "9", "10", "11", "12", "13", "14–16", "17–21", "18", "22", "23", "24", "25" ]
249
43,158
1
false
The maximal activation of cPLA2 requires sustained phosphorylation of Ser505, Ser727 and Ser515 by mitogen-activated protein kinases (MAPKs), MAPK-activated protein kinases and by calcium/calmodulin-dependent protein kinase II, respectively.
[ "14–16" ]
The maximal activation of cPLA2 requires sustained phosphorylation of Ser505, Ser727 and Ser515 by mitogen-activated protein kinases (MAPKs), MAPK-activated protein kinases and by calcium/calmodulin-dependent protein kinase II, respectively.
true
true
true
true
true
7,474
1
INTRODUCTION
1
17–21
[ "B8", "B9", "B10", "B11", "B12", "B13", "B14 B15 B16", "B17 B18 B19 B20 B21", "B18", "B22", "B23", "B24", "B25" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
In addition to acute regulation, expression of cPLA2 through changes in gene transcription is mediated by a number of agents including cytokines, thrombin and growth factors (17–21).
[ "8", "9", "10", "11", "12", "13", "14–16", "17–21", "18", "22", "23", "24", "25" ]
182
43,159
1
false
In addition to acute regulation, expression of cPLA2 through changes in gene transcription is mediated by a number of agents including cytokines, thrombin and growth factors.
[ "17–21" ]
In addition to acute regulation, expression of cPLA2 through changes in gene transcription is mediated by a number of agents including cytokines, thrombin and growth factors.
true
true
true
true
true
7,474
1
INTRODUCTION
1
18
[ "B8", "B9", "B10", "B11", "B12", "B13", "B14 B15 B16", "B17 B18 B19 B20 B21", "B18", "B22", "B23", "B24", "B25" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
The promoter for cPLA2 has been isolated from both human (18) and rat (22).
[ "8", "9", "10", "11", "12", "13", "14–16", "17–21", "18", "22", "23", "24", "25" ]
75
43,160
1
false
The promoter for cPLA2 has been isolated from both human and rat.
[ "18", "22" ]
The promoter for cPLA2 has been isolated from both human and rat.
true
true
true
true
true
7,474
1
INTRODUCTION
1
8
[ "B8", "B9", "B10", "B11", "B12", "B13", "B14 B15 B16", "B17 B18 B19 B20 B21", "B18", "B22", "B23", "B24", "B25" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
A number of putative binding sites for possible regulatory elements have been identified within the promoter, including AP-1 sites, nuclear factor κB sites and glucocorticoid regulatory elements.
[ "8", "9", "10", "11", "12", "13", "14–16", "17–21", "18", "22", "23", "24", "25" ]
195
43,161
0
false
A number of putative binding sites for possible regulatory elements have been identified within the promoter, including AP-1 sites, nuclear factor κB sites and glucocorticoid regulatory elements.
[]
A number of putative binding sites for possible regulatory elements have been identified within the promoter, including AP-1 sites, nuclear factor κB sites and glucocorticoid regulatory elements.
true
true
true
true
true
7,474
1
INTRODUCTION
1
8
[ "B8", "B9", "B10", "B11", "B12", "B13", "B14 B15 B16", "B17 B18 B19 B20 B21", "B18", "B22", "B23", "B24", "B25" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
Truncation of a 2.4 kb region of the promoter fragment down to the last 58 bp of the 5′-untranslated region has been identified in three regulatory regions and indicates that the transcription factor Sp1 can bind to two of these regions (23,24).
[ "8", "9", "10", "11", "12", "13", "14–16", "17–21", "18", "22", "23", "24", "25" ]
245
43,162
0
false
Truncation of a 2.4 kb region of the promoter fragment down to the last 58 bp of the 5′-untranslated region has been identified in three regulatory regions and indicates that the transcription factor Sp1 can bind to two of these regions.
[ "23,24" ]
Truncation of a 2.4 kb region of the promoter fragment down to the last 58 bp of the 5′-untranslated region has been identified in three regulatory regions and indicates that the transcription factor Sp1 can bind to two of these regions.
true
true
true
true
true
7,474
1
INTRODUCTION
1
25
[ "B8", "B9", "B10", "B11", "B12", "B13", "B14 B15 B16", "B17 B18 B19 B20 B21", "B18", "B22", "B23", "B24", "B25" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
In the regulation of cPLA2 promoter, LKLF (lung Krüppel-like factor) as a transcriptional activator also binds to the cPLA2 promoter and may interact with the Sp1 family (25).
[ "8", "9", "10", "11", "12", "13", "14–16", "17–21", "18", "22", "23", "24", "25" ]
175
43,163
1
false
In the regulation of cPLA2 promoter, LKLF (lung Krüppel-like factor) as a transcriptional activator also binds to the cPLA2 promoter and may interact with the Sp1 family.
[ "25" ]
In the regulation of cPLA2 promoter, LKLF (lung Krüppel-like factor) as a transcriptional activator also binds to the cPLA2 promoter and may interact with the Sp1 family.
true
true
true
true
true
7,474
2
INTRODUCTION
1
26–29
[ "B26 B27 B28 B29", "B30", "B31" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
Although Sp1 is required for the transcriptional activation of cPLA2 gene, only a limited number of studies have addressed the mechanisms by which cPLA2 gene expression is controlled.
[ "26–29", "30", "31" ]
183
43,164
0
false
Although Sp1 is required for the transcriptional activation of cPLA2 gene, only a limited number of studies have addressed the mechanisms by which cPLA2 gene expression is controlled.
[]
Although Sp1 is required for the transcriptional activation of cPLA2 gene, only a limited number of studies have addressed the mechanisms by which cPLA2 gene expression is controlled.
true
true
true
true
true
7,475
2
INTRODUCTION
1
26–29
[ "B26 B27 B28 B29", "B30", "B31" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
In addition to enzymatic activation, in this study, we also clarified that PMA could activate the transcription via the Sp1-binding sites of cPLA2α promoter in NSCLC A549 cells.
[ "26–29", "30", "31" ]
177
43,165
0
false
In addition to enzymatic activation, in this study, we also clarified that PMA could activate the transcription via the Sp1-binding sites of cPLA2α promoter in NSCLC A549 cells.
[]
In addition to enzymatic activation, in this study, we also clarified that PMA could activate the transcription via the Sp1-binding sites of cPLA2α promoter in NSCLC A549 cells.
true
true
true
true
true
7,475
2
INTRODUCTION
1
26–29
[ "B26 B27 B28 B29", "B30", "B31" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
We demonstrated that transcription factors c-Jun and Sp1 form a complex to regulate PMA-induced gene expression of cPLA2α as the manner as the c-Jun/Sp1-regulated genes including 12(S)-lipoxygenase, keratin 16, p21WAF1/CIP1 and neuronal nicotinic acetylcholine receptor β4 (26–29).
[ "26–29", "30", "31" ]
281
43,166
1
false
We demonstrated that transcription factors c-Jun and Sp1 form a complex to regulate PMA-induced gene expression of cPLA2α as the manner as the c-Jun/Sp1-regulated genes including 12(S)-lipoxygenase, keratin 16, p21WAF1/CIP1 and neuronal nicotinic acetylcholine receptor β4.
[ "26–29" ]
We demonstrated that transcription factors c-Jun and Sp1 form a complex to regulate PMA-induced gene expression of cPLA2α as the manner as the c-Jun/Sp1-regulated genes including 12(S)-lipoxygenase, keratin 16, p21WAF1/CIP1 and neuronal nicotinic acetylcholine receptor β4.
true
true
true
true
true
7,475
2
INTRODUCTION
1
26–29
[ "B26 B27 B28 B29", "B30", "B31" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
We further performed pull-down and protein–DNA interaction assays to show that nucleolin bound to DNA and activated transcription of cPLA2α in PMA-treated cells.
[ "26–29", "30", "31" ]
161
43,167
0
false
We further performed pull-down and protein–DNA interaction assays to show that nucleolin bound to DNA and activated transcription of cPLA2α in PMA-treated cells.
[]
We further performed pull-down and protein–DNA interaction assays to show that nucleolin bound to DNA and activated transcription of cPLA2α in PMA-treated cells.
true
true
true
true
true
7,475
2
INTRODUCTION
1
30
[ "B26 B27 B28 B29", "B30", "B31" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
Nucleolin is reported to be a ubiquitously expressed multifunctional protein involved in ribosomal biogenesis and the regulation of nucleolar translocation of ribosomal proteins (30).
[ "26–29", "30", "31" ]
183
43,168
1
false
Nucleolin is reported to be a ubiquitously expressed multifunctional protein involved in ribosomal biogenesis and the regulation of nucleolar translocation of ribosomal proteins.
[ "30" ]
Nucleolin is reported to be a ubiquitously expressed multifunctional protein involved in ribosomal biogenesis and the regulation of nucleolar translocation of ribosomal proteins.
true
true
true
true
true
7,475
2
INTRODUCTION
1
31
[ "B26 B27 B28 B29", "B30", "B31" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
Functional role of nucleolin in the activation and repression of gene transcription as well as in the regulation of RNA metabolism has already been reported (31).
[ "26–29", "30", "31" ]
162
43,169
1
false
Functional role of nucleolin in the activation and repression of gene transcription as well as in the regulation of RNA metabolism has already been reported.
[ "31" ]
Functional role of nucleolin in the activation and repression of gene transcription as well as in the regulation of RNA metabolism has already been reported.
true
true
true
true
true
7,475
2
INTRODUCTION
1
26–29
[ "B26 B27 B28 B29", "B30", "B31" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
Our results revealed a new function for nucleolin as a c-Jun/Sp1-interacting partner and transcription activator in PMA-induced gene expression of cPLA2α.
[ "26–29", "30", "31" ]
154
43,170
0
false
Our results revealed a new function for nucleolin as a c-Jun/Sp1-interacting partner and transcription activator in PMA-induced gene expression of cPLA2α.
[]
Our results revealed a new function for nucleolin as a c-Jun/Sp1-interacting partner and transcription activator in PMA-induced gene expression of cPLA2α.
true
true
true
true
true
7,475
0
DISCUSSION
1
7
[ "B7", "B7", "B41", "B42", "B43" ]
18,025,046
pmid-12088280|pmid-15950989|pmid-15896353|pmid-11901304|pmid-3409218|pmid-3130187|pmid-9169405|pmid-9169405|pmid-9169405|pmid-15033900|pmid-16055435|pmid-15777800
The expression of cPLA2 can be regulated in NSCLC (7) and is critical for transformed growth of NSCLC.
[ "7", "7", "41", "42", "43" ]
102
43,171
1
false
The expression of cPLA2 can be regulated in NSCLC and is critical for transformed growth of NSCLC.
[ "7" ]
The expression of cPLA2 can be regulated in NSCLC and is critical for transformed growth of NSCLC.
true
true
true
true
true
7,476
0
DISCUSSION
1
7
[ "B7", "B7", "B41", "B42", "B43" ]
18,025,046
pmid-12088280|pmid-15950989|pmid-15896353|pmid-11901304|pmid-3409218|pmid-3130187|pmid-9169405|pmid-9169405|pmid-9169405|pmid-15033900|pmid-16055435|pmid-15777800
When these cells are treated with a specific inhibitor of the enzyme, or blocking downstream production of prostaglandins with cyclooxygenase inhibitors, resulting in inhibition of anchorage-independent growth of these cells (7).
[ "7", "7", "41", "42", "43" ]
229
43,172
1
false
When these cells are treated with a specific inhibitor of the enzyme, or blocking downstream production of prostaglandins with cyclooxygenase inhibitors, resulting in inhibition of anchorage-independent growth of these cells.
[ "7" ]
When these cells are treated with a specific inhibitor of the enzyme, or blocking downstream production of prostaglandins with cyclooxygenase inhibitors, resulting in inhibition of anchorage-independent growth of these cells.
true
true
true
true
true
7,476
0
DISCUSSION
1
7
[ "B7", "B7", "B41", "B42", "B43" ]
18,025,046
pmid-12088280|pmid-15950989|pmid-15896353|pmid-11901304|pmid-3409218|pmid-3130187|pmid-9169405|pmid-9169405|pmid-9169405|pmid-15033900|pmid-16055435|pmid-15777800
These results suggest that induction of cPLA2 is critical for tumorigenesis.
[ "7", "7", "41", "42", "43" ]
76
43,173
0
false
These results suggest that induction of cPLA2 is critical for tumorigenesis.
[]
These results suggest that induction of cPLA2 is critical for tumorigenesis.
true
true
true
true
true
7,476
0
DISCUSSION
1
41
[ "B7", "B7", "B41", "B42", "B43" ]
18,025,046
pmid-12088280|pmid-15950989|pmid-15896353|pmid-11901304|pmid-3409218|pmid-3130187|pmid-9169405|pmid-9169405|pmid-9169405|pmid-15033900|pmid-16055435|pmid-15777800
Consistent with this finding, lung tumorigenesis is inhibited in mice that are deficient in cPLA2 (41).
[ "7", "7", "41", "42", "43" ]
103
43,174
1
false
Consistent with this finding, lung tumorigenesis is inhibited in mice that are deficient in cPLA2.
[ "41" ]
Consistent with this finding, lung tumorigenesis is inhibited in mice that are deficient in cPLA2.
true
true
true
true
true
7,476
0
DISCUSSION
1
7
[ "B7", "B7", "B41", "B42", "B43" ]
18,025,046
pmid-12088280|pmid-15950989|pmid-15896353|pmid-11901304|pmid-3409218|pmid-3130187|pmid-9169405|pmid-9169405|pmid-9169405|pmid-15033900|pmid-16055435|pmid-15777800
In this study, we first found that PMA induced gene expression of cPLA2α in NSCLC.
[ "7", "7", "41", "42", "43" ]
82
43,175
0
false
In this study, we first found that PMA induced gene expression of cPLA2α in NSCLC.
[]
In this study, we first found that PMA induced gene expression of cPLA2α in NSCLC.
true
true
true
true
true
7,476
0
DISCUSSION
1
7
[ "B7", "B7", "B41", "B42", "B43" ]
18,025,046
pmid-12088280|pmid-15950989|pmid-15896353|pmid-11901304|pmid-3409218|pmid-3130187|pmid-9169405|pmid-9169405|pmid-9169405|pmid-15033900|pmid-16055435|pmid-15777800
It has been known that PMA-activated PKC signal transduction pathway is thought to be involved in the oncogene action in NSCLC and enzymatic activation of cPLA2.
[ "7", "7", "41", "42", "43" ]
161
43,176
0
false
It has been known that PMA-activated PKC signal transduction pathway is thought to be involved in the oncogene action in NSCLC and enzymatic activation of cPLA2.
[]
It has been known that PMA-activated PKC signal transduction pathway is thought to be involved in the oncogene action in NSCLC and enzymatic activation of cPLA2.
true
true
true
true
true
7,476
0
DISCUSSION
1
42
[ "B7", "B7", "B41", "B42", "B43" ]
18,025,046
pmid-12088280|pmid-15950989|pmid-15896353|pmid-11901304|pmid-3409218|pmid-3130187|pmid-9169405|pmid-9169405|pmid-9169405|pmid-15033900|pmid-16055435|pmid-15777800
Activation of PKC with PMA impairs progression of lung adenocarcinoma cells from early G1 phase into S phase (42).
[ "7", "7", "41", "42", "43" ]
114
43,177
1
false
Activation of PKC with PMA impairs progression of lung adenocarcinoma cells from early G1 phase into S phase.
[ "42" ]
Activation of PKC with PMA impairs progression of lung adenocarcinoma cells from early G1 phase into S phase.
true
true
true
true
true
7,476
0
DISCUSSION
1
43
[ "B7", "B7", "B41", "B42", "B43" ]
18,025,046
pmid-12088280|pmid-15950989|pmid-15896353|pmid-11901304|pmid-3409218|pmid-3130187|pmid-9169405|pmid-9169405|pmid-9169405|pmid-15033900|pmid-16055435|pmid-15777800
The broad-range PKC inhibitor staurosporine analog, PKC 412, induces apoptosis in SCLC cells and sensitizes NSCLC cells to apoptosis induced by DNA-damaging agents (43).
[ "7", "7", "41", "42", "43" ]
169
43,178
1
false
The broad-range PKC inhibitor staurosporine analog, PKC 412, induces apoptosis in SCLC cells and sensitizes NSCLC cells to apoptosis induced by DNA-damaging agents.
[ "43" ]
The broad-range PKC inhibitor staurosporine analog, PKC 412, induces apoptosis in SCLC cells and sensitizes NSCLC cells to apoptosis induced by DNA-damaging agents.
true
true
true
true
true
7,476
0
DISCUSSION
1
7
[ "B7", "B7", "B41", "B42", "B43" ]
18,025,046
pmid-12088280|pmid-15950989|pmid-15896353|pmid-11901304|pmid-3409218|pmid-3130187|pmid-9169405|pmid-9169405|pmid-9169405|pmid-15033900|pmid-16055435|pmid-15777800
Taking these results together, we concluded that PMA-induced expression of cPLA2α might be related to either a cause or a consequence of PMA-regulated tumorigenesis of NSCLC.
[ "7", "7", "41", "42", "43" ]
174
43,179
0
false
Taking these results together, we concluded that PMA-induced expression of cPLA2α might be related to either a cause or a consequence of PMA-regulated tumorigenesis of NSCLC.
[]
Taking these results together, we concluded that PMA-induced expression of cPLA2α might be related to either a cause or a consequence of PMA-regulated tumorigenesis of NSCLC.
true
true
true
true
true
7,476
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
In the regulation of gene expression, previous studies have reported that c-Jun/Sp1 complex is critical for various different gene expressions, e.g.
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
148
43,180
0
false
In the regulation of gene expression, previous studies have reported that c-Jun/Sp1 complex is critical for various different gene expressions, e.g.
[]
In the regulation of gene expression, previous studies have reported that c-Jun/Sp1 complex is critical for various different gene expressions, e.g.
true
true
true
true
true
7,477
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
12(S)-lipoxygenase, keratin 16, p21WAF1/CIP1 and neuronal nicotinic acetylcholine receptor β4 (26–29).
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
102
43,181
1
false
12(S)-lipoxygenase, keratin 16, p21WAF1/CIP1 and neuronal nicotinic acetylcholine receptor β4.
[ "26–29" ]
12(S)-lipoxygenase, keratin 16, p21WAF1/CIP1 and neuronal nicotinic acetylcholine receptor β4.
false
false
true
true
false
7,477
1
DISCUSSION
1
23
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
Although overexpression of c-Jun and Sp1 produces a synergistic increase in the rat cPLA2 promoter activity, no evidence shows that the formation of c-Jun/Sp1 complex and the complex binding to the rat cPLA2 promoter are observed (23).
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
235
43,182
1
false
Although overexpression of c-Jun and Sp1 produces a synergistic increase in the rat cPLA2 promoter activity, no evidence shows that the formation of c-Jun/Sp1 complex and the complex binding to the rat cPLA2 promoter are observed.
[ "23" ]
Although overexpression of c-Jun and Sp1 produces a synergistic increase in the rat cPLA2 promoter activity, no evidence shows that the formation of c-Jun/Sp1 complex and the complex binding to the rat cPLA2 promoter are observed.
true
true
true
true
true
7,477
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
However, we first clarified that PMA induced c-Jun/Sp1 interaction and the complex bound to Sp1-binding sites of human cPLA2α promoter, resulting in the induction of transcriptional activation.
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
193
43,183
0
false
However, we first clarified that PMA induced c-Jun/Sp1 interaction and the complex bound to Sp1-binding sites of human cPLA2α promoter, resulting in the induction of transcriptional activation.
[]
However, we first clarified that PMA induced c-Jun/Sp1 interaction and the complex bound to Sp1-binding sites of human cPLA2α promoter, resulting in the induction of transcriptional activation.
true
true
true
true
true
7,477
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
In addition, we found that nucleolin was also a coactivator interacting with c-Jun to regulate PMA-induced transcription of cPLA2α gene.
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
136
43,184
0
false
In addition, we found that nucleolin was also a coactivator interacting with c-Jun to regulate PMA-induced transcription of cPLA2α gene.
[]
In addition, we found that nucleolin was also a coactivator interacting with c-Jun to regulate PMA-induced transcription of cPLA2α gene.
true
true
true
true
true
7,477
1
DISCUSSION
1
30
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
Nucleolin is a ubiquitous, nonhistone nucleolar phosphoprotein of exponentially growing eukaryotic cells, which is directly involved in the regulation of ribosome biogenesis, the processing of ribosomal RNA, mRNA stability, transcriptional regulation and cell proliferation, and it is also a downstream target of several...
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
355
43,185
1
false
Nucleolin is a ubiquitous, nonhistone nucleolar phosphoprotein of exponentially growing eukaryotic cells, which is directly involved in the regulation of ribosome biogenesis, the processing of ribosomal RNA, mRNA stability, transcriptional regulation and cell proliferation, and it is also a downstream target of several...
[ "30" ]
Nucleolin is a ubiquitous, nonhistone nucleolar phosphoprotein of exponentially growing eukaryotic cells, which is directly involved in the regulation of ribosome biogenesis, the processing of ribosomal RNA, mRNA stability, transcriptional regulation and cell proliferation, and it is also a downstream target of several...
true
true
true
true
true
7,477
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
Matching our results, the functional role of nucleolin involved in the transcriptional activation of gene expression has been found.
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
132
43,186
0
false
Matching our results, the functional role of nucleolin involved in the transcriptional activation of gene expression has been found.
[]
Matching our results, the functional role of nucleolin involved in the transcriptional activation of gene expression has been found.
true
true
true
true
true
7,477
1
DISCUSSION
1
44
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
Nucleolin binds acetylated interferon regulatory factor-2 (IRF-2) to enhance H4 promoter activity (44) and plays as a key activator of HPV18 oncogene transcription in cervical cancer (45).
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
188
43,187
1
false
Nucleolin binds acetylated interferon regulatory factor-2 (IRF-2) to enhance H4 promoter activity and plays as a key activator of HPV18 oncogene transcription in cervical cancer.
[ "44", "45" ]
Nucleolin binds acetylated interferon regulatory factor-2 (IRF-2) to enhance H4 promoter activity and plays as a key activator of HPV18 oncogene transcription in cervical cancer.
true
true
true
true
true
7,477
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
Nucleolin also binds transcription factors Myb and tumor suppressor Rb to regulate Myb transcriptional activity and tumor development (46,47).
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
142
43,188
0
false
Nucleolin also binds transcription factors Myb and tumor suppressor Rb to regulate Myb transcriptional activity and tumor development.
[ "46,47" ]
Nucleolin also binds transcription factors Myb and tumor suppressor Rb to regulate Myb transcriptional activity and tumor development.
true
true
true
true
true
7,477
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
These findings suggest that nucleolin may act as a transcriptional regulator via interacting with activators.
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
109
43,189
0
false
These findings suggest that nucleolin may act as a transcriptional regulator via interacting with activators.
[]
These findings suggest that nucleolin may act as a transcriptional regulator via interacting with activators.
true
true
true
true
true
7,477
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
Indeed, in the experiments of immunoprecipitation and DAPA, we found that nucleolin bound and bridged c-Jun to Sp1-binding sites of cPLA2α promoter (Figures 4C and 7B).
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
168
43,190
0
false
Indeed, in the experiments of immunoprecipitation and DAPA, we found that nucleolin bound and bridged c-Jun to Sp1-binding sites of cPLA2α promoter (Figures 4C and 7B).
[]
Indeed, in the experiments of immunoprecipitation and DAPA, we found that nucleolin bound and bridged c-Jun to Sp1-binding sites of cPLA2α promoter (Figures 4C and 7B).
true
true
true
true
true
7,477
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
These results suggested the possibility that nucleolin participated in the regulation of c-Jun/Sp1-regulated genes, e.g.
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
120
43,191
0
false
These results suggested the possibility that nucleolin participated in the regulation of c-Jun/Sp1-regulated genes, e.g.
[]
These results suggested the possibility that nucleolin participated in the regulation of c-Jun/Sp1-regulated genes, e.g.
true
true
true
true
true
7,477
1
DISCUSSION
1
48
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
12(S)-lipoxygenase (Figure 7D) and p21WAF1/CIP1 to regulate cell growth (48).
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
77
43,192
1
false
12(S)-lipoxygenase (Figure 7D) and p21WAF1/CIP1 to regulate cell growth.
[ "48" ]
12(S)-lipoxygenase (Figure 7D) and p21WAF1/CIP1 to regulate cell growth.
false
false
true
true
false
7,477
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
From our study, we can conclude that for PMA-induced cPLA2α gene expression, and nucleolin acts as a coactivator via cooperation of c-Jun transcriptional factor.
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
161
43,193
0
false
From our study, we can conclude that for PMA-induced cPLA2α gene expression, and nucleolin acts as a coactivator via cooperation of c-Jun transcriptional factor.
[]
From our study, we can conclude that for PMA-induced cPLA2α gene expression, and nucleolin acts as a coactivator via cooperation of c-Jun transcriptional factor.
true
true
true
true
true
7,477
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
However, the nucleolin/c-Jun complex had no effect on AP1-regulated promoter activation (Figures 6C and 8B).
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
108
43,194
0
false
However, the nucleolin/c-Jun complex had no effect on AP1-regulated promoter activation (Figures 6C and 8B).
[]
However, the nucleolin/c-Jun complex had no effect on AP1-regulated promoter activation.
true
true
true
true
true
7,477
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
The different binding affinity between nucleolin/c-Jun to Sp1-binding site and to AP1-binding site might be caused by the stereo-recognition of complex to the Sp1 binding but not AP1-binding sequences.
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
201
43,195
0
false
The different binding affinity between nucleolin/c-Jun to Sp1-binding site and to AP1-binding site might be caused by the stereo-recognition of complex to the Sp1 binding but not AP1-binding sequences.
[]
The different binding affinity between nucleolin/c-Jun to Sp1-binding site and to AP1-binding site might be caused by the stereo-recognition of complex to the Sp1 binding but not AP1-binding sequences.
true
true
true
true
true
7,477
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
Consistent with the role of nucleolin in the regulation of mRNA stability, we found that nucleolin also contributed to the stabilization of cPLA2α mRNA.
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
152
43,196
0
false
Consistent with the role of nucleolin in the regulation of mRNA stability, we found that nucleolin also contributed to the stabilization of cPLA2α mRNA.
[]
Consistent with the role of nucleolin in the regulation of mRNA stability, we found that nucleolin also contributed to the stabilization of cPLA2α mRNA.
true
true
true
true
true
7,477
1
DISCUSSION
1
49
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
Since without identical nucleolin-binding site UCCCGA but with HuR-binding element AUUUA is found within the cPLA2α 3′UTR sequence, the effect of nucleolin on the stabilization of cPLA2α mRNA might result from the cooperation of nucleolin with RNA-binding proteins as well as the basal expression of GADD45α mRNA is regu...
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
367
43,197
1
false
Since without identical nucleolin-binding site UCCCGA but with HuR-binding element AUUUA is found within the cPLA2α 3′UTR sequence, the effect of nucleolin on the stabilization of cPLA2α mRNA might result from the cooperation of nucleolin with RNA-binding proteins as well as the basal expression of GADD45α mRNA is regu...
[ "49" ]
Since without identical nucleolin-binding site UCCCGA but with HuR-binding element AUUUA is found within the cPLA2α 3′UTR sequence, the effect of nucleolin on the stabilization of cPLA2α mRNA might result from the cooperation of nucleolin with RNA-binding proteins as well as the basal expression of GADD45α mRNA is regu...
true
true
true
true
true
7,477
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
Indeed, we found that RNA-binding protein HuR bound to AUUUA of cPLA2α 3′UTR sequence and enhanced the mRNA stability (our unpublished data).
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
141
43,198
0
false
Indeed, we found that RNA-binding protein HuR bound to AUUUA of cPLA2α 3′UTR sequence and enhanced the mRNA stability (our unpublished data).
[]
Indeed, we found that RNA-binding protein HuR bound to AUUUA of cPLA2α 3′UTR sequence and enhanced the mRNA stability (our unpublished data).
true
true
true
true
true
7,477
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
Although PMA had no effect on the stabilization of cPLA2α mRNA, our data showed that nucleolin was also involved in the regulation of PMA-induced transcriptional activation of cPLA2α gene.
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
188
43,199
0
false
Although PMA had no effect on the stabilization of cPLA2α mRNA, our data showed that nucleolin was also involved in the regulation of PMA-induced transcriptional activation of cPLA2α gene.
[]
Although PMA had no effect on the stabilization of cPLA2α mRNA, our data showed that nucleolin was also involved in the regulation of PMA-induced transcriptional activation of cPLA2α gene.
true
true
true
true
true
7,477
1
DISCUSSION
1
26–29
[ "B26 B27 B28 B29", "B23", "B30", "B44", "B45", "B46", "B47", "B48", "B49" ]
18,025,046
pmid-9201969|pmid-11375391|pmid-9988766|pmid-10867029|pmid-9525925|pmid-15689183|pmid-8381049|pmid-10978317|pmid-11479288|pmid-8940164|pmid-7800505|pmid-15548519|pmid-15322111|pmid-10749741|pmid-7800505|pmid-8148385|pmid-11559711|pmid-11042196|pmid-15540987|pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-1...
These results revealed that nucleolin plays dual functions of transcriptional and post-transcriptional activity in the regulation of cPLA2α gene.
[ "26–29", "23", "30", "44", "45", "46", "47", "48", "49" ]
145
43,200
0
false
These results revealed that nucleolin plays dual functions of transcriptional and post-transcriptional activity in the regulation of cPLA2α gene.
[]
These results revealed that nucleolin plays dual functions of transcriptional and post-transcriptional activity in the regulation of cPLA2α gene.
true
true
true
true
true
7,477
2
DISCUSSION
1
39
[ "B39", "B50", "B51", "B52", "B39" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
It is known that the motif (U/G)CCCG(A/G) is responsible for the binding of nucleolin to RNA (39).
[ "39", "50", "51", "52", "39" ]
98
43,201
1
false
It is known that the motif (U/G)CCCG(A/G) is responsible for the binding of nucleolin to RNA.
[ "39" ]
It is known that the motif (U/G)CCCG(A/G) is responsible for the binding of nucleolin to RNA.
true
true
true
true
true
7,478
2
DISCUSSION
1
39
[ "B39", "B50", "B51", "B52", "B39" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
However, we found that the binding of nucleolin to the GC-rich Sp1 site within cPLA2α promoter was in an Sp1-independent manner.
[ "39", "50", "51", "52", "39" ]
128
43,202
0
false
However, we found that the binding of nucleolin to the GC-rich Sp1 site within cPLA2α promoter was in an Sp1-independent manner.
[]
However, we found that the binding of nucleolin to the GC-rich Sp1 site within cPLA2α promoter was in an Sp1-independent manner.
true
true
true
true
true
7,478
2
DISCUSSION
1
39
[ "B39", "B50", "B51", "B52", "B39" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
Thus, nucleolin might gain access to DNA through two pathways.
[ "39", "50", "51", "52", "39" ]
62
43,203
0
false
Thus, nucleolin might gain access to DNA through two pathways.
[]
Thus, nucleolin might gain access to DNA through two pathways.
true
true
true
true
true
7,478
2
DISCUSSION
1
39
[ "B39", "B50", "B51", "B52", "B39" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
First, since Sp1 siRNA had no effect on the binding of nucleolin to Sp1 element, indicating that nucleolin might directly bind to DNA and recruit c-Jun transcriptional factor to Sp1 sites and then activate gene expression.
[ "39", "50", "51", "52", "39" ]
222
43,204
0
false
First, since Sp1 siRNA had no effect on the binding of nucleolin to Sp1 element, indicating that nucleolin might directly bind to DNA and recruit c-Jun transcriptional factor to Sp1 sites and then activate gene expression.
[]
First, since Sp1 siRNA had no effect on the binding of nucleolin to Sp1 element, indicating that nucleolin might directly bind to DNA and recruit c-Jun transcriptional factor to Sp1 sites and then activate gene expression.
true
true
true
true
true
7,478
2
DISCUSSION
1
50
[ "B39", "B50", "B51", "B52", "B39" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
Nucleolin is a matrix attachment region (MAR)-binding protein to provide a link between DNA and nuclear matrix scaffolding (50).
[ "39", "50", "51", "52", "39" ]
128
43,205
1
false
Nucleolin is a matrix attachment region (MAR)-binding protein to provide a link between DNA and nuclear matrix scaffolding.
[ "50" ]
Nucleolin is a matrix attachment region (MAR)-binding protein to provide a link between DNA and nuclear matrix scaffolding.
true
true
true
true
true
7,478
2
DISCUSSION
1
39
[ "B39", "B50", "B51", "B52", "B39" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
In addition, nucleolin was also found to bind to the NFκB DNA-binding motif and the KLF2 promoter (51,52).
[ "39", "50", "51", "52", "39" ]
106
43,206
0
false
In addition, nucleolin was also found to bind to the NFκB DNA-binding motif and the KLF2 promoter.
[ "51,52" ]
In addition, nucleolin was also found to bind to the NFκB DNA-binding motif and the KLF2 promoter.
true
true
true
true
true
7,478
2
DISCUSSION
1
39
[ "B39", "B50", "B51", "B52", "B39" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
Thus, nucleolin may interact with DNA and other transcriptional factors, such as c-Jun, to regulate transcription.
[ "39", "50", "51", "52", "39" ]
114
43,207
0
false
Thus, nucleolin may interact with DNA and other transcriptional factors, such as c-Jun, to regulate transcription.
[]
Thus, nucleolin may interact with DNA and other transcriptional factors, such as c-Jun, to regulate transcription.
true
true
true
true
true
7,478
2
DISCUSSION
1
39
[ "B39", "B50", "B51", "B52", "B39" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
It is very interesting to note that whether the binding of nucleolin to GC-rich Sp1 site has the sequence specificity.
[ "39", "50", "51", "52", "39" ]
118
43,208
0
false
It is very interesting to note that whether the binding of nucleolin to GC-rich Sp1 site has the sequence specificity.
[]
It is very interesting to note that whether the binding of nucleolin to GC-rich Sp1 site has the sequence specificity.
true
true
true
true
true
7,478
2
DISCUSSION
1
39
[ "B39", "B50", "B51", "B52", "B39" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
Contrary to the binding of nucleolin to cPLA2α promoter, we found that SV40 promoter containing Sp1-binding sites was not regulated by nucleolin.
[ "39", "50", "51", "52", "39" ]
145
43,209
0
false
Contrary to the binding of nucleolin to cPLA2α promoter, we found that SV40 promoter containing Sp1-binding sites was not regulated by nucleolin.
[]
Contrary to the binding of nucleolin to cPLA2α promoter, we found that SV40 promoter containing Sp1-binding sites was not regulated by nucleolin.
true
true
true
true
true
7,478
2
DISCUSSION
1
39
[ "B39", "B50", "B51", "B52", "B39" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
Furthermore, we also found that the interaction between nucleolin and Sp1-binding site was not occurred in all Sp1-regulated promoters such as gastrin.
[ "39", "50", "51", "52", "39" ]
151
43,210
0
false
Furthermore, we also found that the interaction between nucleolin and Sp1-binding site was not occurred in all Sp1-regulated promoters such as gastrin.
[]
Furthermore, we also found that the interaction between nucleolin and Sp1-binding site was not occurred in all Sp1-regulated promoters such as gastrin.
true
true
true
true
true
7,478
2
DISCUSSION
1
39
[ "B39", "B50", "B51", "B52", "B39" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
It is possible that the nucleotide sequence surrounding the AGCCC and UCCCGA can modulate the interaction of nucleolin with DNA and RNA (39), respectively.
[ "39", "50", "51", "52", "39" ]
155
43,211
1
false
It is possible that the nucleotide sequence surrounding the AGCCC and UCCCGA can modulate the interaction of nucleolin with DNA and RNA, respectively.
[ "39" ]
It is possible that the nucleotide sequence surrounding the AGCCC and UCCCGA can modulate the interaction of nucleolin with DNA and RNA, respectively.
true
true
true
true
true
7,478
2
DISCUSSION
1
39
[ "B39", "B50", "B51", "B52", "B39" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
Second, access of nucleolin to cPLA2α promoter may also skip from direct binding but be bridged by other factors to DNA.
[ "39", "50", "51", "52", "39" ]
120
43,212
0
false
Second, access of nucleolin to cPLA2α promoter may also skip from direct binding but be bridged by other factors to DNA.
[]
Second, access of nucleolin to cPLA2α promoter may also skip from direct binding but be bridged by other factors to DNA.
true
true
true
true
true
7,478
2
DISCUSSION
1
39
[ "B39", "B50", "B51", "B52", "B39" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
Although there was no effect of Sp1 siRNA on nucleolin binding, we could not rule out the possibility that the binding of nucleolin to DNA might have occurred concomitant with Sp1-like proteins binding.
[ "39", "50", "51", "52", "39" ]
202
43,213
0
false
Although there was no effect of Sp1 siRNA on nucleolin binding, we could not rule out the possibility that the binding of nucleolin to DNA might have occurred concomitant with Sp1-like proteins binding.
[]
Although there was no effect of Sp1 siRNA on nucleolin binding, we could not rule out the possibility that the binding of nucleolin to DNA might have occurred concomitant with Sp1-like proteins binding.
true
true
true
true
true
7,478
2
DISCUSSION
1
39
[ "B39", "B50", "B51", "B52", "B39" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
In addition, in spite of nucleolin and Sp1 bound to DNA was dependent on Sp1-binding sites, the binding of Sp1 to DNA was in a nucleolin-independent manner.
[ "39", "50", "51", "52", "39" ]
156
43,214
0
false
In addition, in spite of nucleolin and Sp1 bound to DNA was dependent on Sp1-binding sites, the binding of Sp1 to DNA was in a nucleolin-independent manner.
[]
In addition, in spite of nucleolin and Sp1 bound to DNA was dependent on Sp1-binding sites, the binding of Sp1 to DNA was in a nucleolin-independent manner.
true
true
true
true
true
7,478
2
DISCUSSION
1
39
[ "B39", "B50", "B51", "B52", "B39" ]
18,025,046
pmid-10973489|pmid-12954631|pmid-10506225|pmid-11262397|pmid-10544174|pmid-9108024|pmid-8676391|pmid-7799955|pmid-16025516|pmid-16571724|pmid-8676391
These results suggested that Sp1/c-Jun and nucleolin/c-Jun complexes could together or independently bind to Sp1-binding sites and regulate PMA-induced transcriptional activation of cPLA2α gene.
[ "39", "50", "51", "52", "39" ]
194
43,215
0
false
These results suggested that Sp1/c-Jun and nucleolin/c-Jun complexes could together or independently bind to Sp1-binding sites and regulate PMA-induced transcriptional activation of cPLA2α gene.
[]
These results suggested that Sp1/c-Jun and nucleolin/c-Jun complexes could together or independently bind to Sp1-binding sites and regulate PMA-induced transcriptional activation of cPLA2α gene.
true
true
true
true
true
7,478
3
DISCUSSION
1
7
[ "B7", "B41", "B47", "B53" ]
18,025,046
pmid-9169405|pmid-15033900|pmid-16698799|pmid-12138209
In conclusion, we have identified the functional interaction between c-Jun, nucleolin and Sp1 to mediate cPLA2α expression in PMA signal-activated human tumor cells.
[ "7", "41", "47", "53" ]
165
43,216
0
false
In conclusion, we have identified the functional interaction between c-Jun, nucleolin and Sp1 to mediate cPLA2α expression in PMA signal-activated human tumor cells.
[]
In conclusion, we have identified the functional interaction between c-Jun, nucleolin and Sp1 to mediate cPLA2α expression in PMA signal-activated human tumor cells.
true
true
true
true
true
7,479
3
DISCUSSION
1
7
[ "B7", "B41", "B47", "B53" ]
18,025,046
pmid-9169405|pmid-15033900|pmid-16698799|pmid-12138209
Our results demonstrate that the activation of the PMA signaling pathway leads to the binding of c-Jun/nucleolin and c-Jun/Sp1 complexes to the cPLA2α promoter, resulting in the transcriptional activation of cPLA2α gene.
[ "7", "41", "47", "53" ]
220
43,217
0
false
Our results demonstrate that the activation of the PMA signaling pathway leads to the binding of c-Jun/nucleolin and c-Jun/Sp1 complexes to the cPLA2α promoter, resulting in the transcriptional activation of cPLA2α gene.
[]
Our results demonstrate that the activation of the PMA signaling pathway leads to the binding of c-Jun/nucleolin and c-Jun/Sp1 complexes to the cPLA2α promoter, resulting in the transcriptional activation of cPLA2α gene.
true
true
true
true
true
7,479
3
DISCUSSION
1
7
[ "B7", "B41", "B47", "B53" ]
18,025,046
pmid-9169405|pmid-15033900|pmid-16698799|pmid-12138209
Based on the expression of cPLA2α is critical for transformed growth of NSCLC and tumorigenesis (7,41), our study suggested that nucleolin, in addition to contribute to the process of tumor development by linking to major tumor suppressors, Rb and p53 (47,53), could associate with transcription factor c-Jun and up-regu...
[ "7", "41", "47", "53" ]
403
43,218
0
false
Based on the expression of cPLA2α is critical for transformed growth of NSCLC and tumorigenesis, our study suggested that nucleolin, in addition to contribute to the process of tumor development by linking to major tumor suppressors, Rb and p53, could associate with transcription factor c-Jun and up-regulate cPLA2α exp...
[ "7,41", "47,53" ]
Based on the expression of cPLA2α is critical for transformed growth of NSCLC and tumorigenesis, our study suggested that nucleolin, in addition to contribute to the process of tumor development by linking to major tumor suppressors, Rb and p53, could associate with transcription factor c-Jun and up-regulate cPLA2α exp...
true
true
true
true
true
7,479