Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
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DISCUSSION
1
42
[ "bib30", "bib39", "bib40", "bib41", "bib42", "bib15", "bib43" ]
18,039,949
pmid-16081850|pmid-9764847|pmid-17603494|pmid-14678257|pmid-15099362|pmid-16200068|pmid-17307864
Thus, although Th17 cells may be the major drivers of keratinocyte hyperplasia and inflammatory cytokine production, Th1 cells may be important for leukocyte activation and for sustaining a network of >100 genes linked to IFN-γ signaling (42).
[ "30", "39", "40", "41", "42", "15", "43" ]
243
44,019
1
false
Thus, although Th17 cells may be the major drivers of keratinocyte hyperplasia and inflammatory cytokine production, Th1 cells may be important for leukocyte activation and for sustaining a network of >100 genes linked to IFN-γ signaling.
[ "42" ]
Thus, although Th17 cells may be the major drivers of keratinocyte hyperplasia and inflammatory cytokine production, Th1 cells may be important for leukocyte activation and for sustaining a network of >100 genes linked to IFN-γ signaling.
true
true
true
true
true
7,610
5
DISCUSSION
1
30
[ "bib30", "bib39", "bib40", "bib41", "bib42", "bib15", "bib43" ]
18,039,949
pmid-16081850|pmid-9764847|pmid-17603494|pmid-14678257|pmid-15099362|pmid-16200068|pmid-17307864
In addition, there may be important functional interactions between Th17 and Th1 cells, as cross-regulation has been recently demonstrated in model systems (15, 43).
[ "30", "39", "40", "41", "42", "15", "43" ]
165
44,020
0
false
In addition, there may be important functional interactions between Th17 and Th1 cells, as cross-regulation has been recently demonstrated in model systems.
[ "15, 43" ]
In addition, there may be important functional interactions between Th17 and Th1 cells, as cross-regulation has been recently demonstrated in model systems.
true
true
true
true
true
7,610
5
DISCUSSION
1
30
[ "bib30", "bib39", "bib40", "bib41", "bib42", "bib15", "bib43" ]
18,039,949
pmid-16081850|pmid-9764847|pmid-17603494|pmid-14678257|pmid-15099362|pmid-16200068|pmid-17307864
More work needs to be done to delineate the specific roles of Th17 and Th1 cells in psoriasis and in other examples of autoimmune inflammation.
[ "30", "39", "40", "41", "42", "15", "43" ]
143
44,021
0
false
More work needs to be done to delineate the specific roles of Th17 and Th1 cells in psoriasis and in other examples of autoimmune inflammation.
[]
More work needs to be done to delineate the specific roles of Th17 and Th1 cells in psoriasis and in other examples of autoimmune inflammation.
true
true
true
true
true
7,610
0
INTRODUCTION
1
1
[ "B1", "B2", "B4", "B5" ]
17,594,166
pmid-12019579|pmid-8831545|pmid-9153168|pmid-14685095|NA
Since the first laparoscopic cholecystectomy was performed in 1897, it has come to be accepted as the gold standard treatment of benign pathologic conditions of the gallbladder.1 Many previous studies have clearly shown that laparoscopic surgery resulted in a shorter hospital stay, less pain, a better cosmetic effect, ...
[ "1", "2", "4", "5" ]
713
44,022
0
false
Since the first laparoscopic cholecystectomy was performed in 1897, it has come to be accepted as the gold standard treatment of benign pathologic conditions of the gallbladder.1 Many previous studies have clearly shown that laparoscopic surgery resulted in a shorter hospital stay, less pain, a better cosmetic effect, ...
[]
Since the first laparoscopic cholecystectomy was performed in 1897, it has come to be accepted as the gold standard treatment of benign pathologic conditions of the gallbladder.1 Many previous studies have clearly shown that laparoscopic surgery resulted in a shorter hospital stay, less pain, a better cosmetic effect, ...
true
true
false
true
false
7,611
1
INTRODUCTION
1
6
[ "B6" ]
17,594,166
pmid-9918973|pmid-3280462|NA|pmid-12008765
Currently, an increasing number of surgical procedures are being performed with an emphasis on minimizing trauma to the patient.
[ "6" ]
128
44,023
0
false
Currently, an increasing number of surgical procedures are being performed with an emphasis on minimizing trauma to the patient.
[]
Currently, an increasing number of surgical procedures are being performed with an emphasis on minimizing trauma to the patient.
true
true
true
true
true
7,612
1
INTRODUCTION
1
6
[ "B6" ]
17,594,166
pmid-9918973|pmid-3280462|NA|pmid-12008765
To accomplish this, more complex and precise movement of the laparoscopic instruments are required.
[ "6" ]
99
44,024
0
false
To accomplish this, more complex and precise movement of the laparoscopic instruments are required.
[]
To accomplish this, more complex and precise movement of the laparoscopic instruments are required.
true
true
true
true
true
7,612
1
INTRODUCTION
1
6
[ "B6" ]
17,594,166
pmid-9918973|pmid-3280462|NA|pmid-12008765
The introduction of robotic and computer-assisted surgical systems has allowed for tremendous progress in the field of minimally invasive cardiac surgery6 and has the potential to allow surgeons to overcome several difficulties encountered during laparoscopic surgery.
[ "6" ]
268
44,025
0
false
The introduction of robotic and computer-assisted surgical systems has allowed for tremendous progress in the field of minimally invasive cardiac surgery6 and has the potential to allow surgeons to overcome several difficulties encountered during laparoscopic surgery.
[]
The introduction of robotic and computer-assisted surgical systems has allowed for tremendous progress in the field of minimally invasive cardiac surgery6 and has the potential to allow surgeons to overcome several difficulties encountered during laparoscopic surgery.
true
true
true
true
true
7,612
2
INTRODUCTION
0
null
null
17,594,166
pmid-10612764|pmid-9685550
We herein report the first Korean experience of laparoscopic cholecystectomy assisted by a da Vinci system (The Intuitive Surgical Endoscopic Instrument Control System), focusing on the introduction of the system and perspectives on robotic surgery.
null
249
44,026
0
false
null
null
We herein report the first Korean experience of laparoscopic cholecystectomy assisted by a da Vinci system (The Intuitive Surgical Endoscopic Instrument Control System), focusing on the introduction of the system and perspectives on robotic surgery.
true
true
true
true
true
7,613
0
DISCUSSION
1
7
[ "B7" ]
17,594,166
pmid-12019579|pmid-8831545|pmid-9153168|pmid-14685095|NA
Since 1921 when the Czech playwright Karel Capek introduced the term "robot" in his play, 'Rossum's Universal Robot', it has been a popular term.7 In his play, the term simply referred to a machine performing simple repetitive tasks in the place of human beings.
[ "7" ]
262
44,027
0
false
Since 1921 when the Czech playwright Karel Capek introduced the term "robot" in his play, 'Rossum's Universal Robot', it has been a popular term.7 In his play, the term simply referred to a machine performing simple repetitive tasks in the place of human beings.
[]
Since 1921 when the Czech playwright Karel Capek introduced the term "robot" in his play, 'Rossum's Universal Robot', it has been a popular term.7 In his play, the term simply referred to a machine performing simple repetitive tasks in the place of human beings.
true
true
true
true
true
7,614
0
DISCUSSION
1
7
[ "B7" ]
17,594,166
pmid-12019579|pmid-8831545|pmid-9153168|pmid-14685095|NA
Now, there have been so many advancements in science and technology that extremely delicate and complex motions and missions can now be performed with robotics.
[ "7" ]
160
44,028
0
false
Now, there have been so many advancements in science and technology that extremely delicate and complex motions and missions can now be performed with robotics.
[]
Now, there have been so many advancements in science and technology that extremely delicate and complex motions and missions can now be performed with robotics.
true
true
true
true
true
7,614
1
DISCUSSION
1
8
[ "B8", "B9", "B10" ]
17,594,166
pmid-9918973|pmid-3280462|NA|pmid-12008765
The history of robotics in surgery begins with the Puma 560, a robot used in 1985 to perform neurosurgical biopsies with improved precision.8 A few years later, transurethral resection of the prostate was performed using the same robot system.9
[ "8", "9", "10" ]
244
44,029
0
false
The history of robotics in surgery begins with the Puma 560, a robot used in 1985 to perform neurosurgical biopsies with improved precision.8 A few years later, transurethral resection of the prostate was performed using the same robot system.9
[]
The history of robotics in surgery begins with the Puma 560, a robot used in 1985 to perform neurosurgical biopsies with improved precision.8 A few years later, transurethral resection of the prostate was performed using the same robot system.9
true
true
false
true
false
7,615
1
DISCUSSION
1
8
[ "B8", "B9", "B10" ]
17,594,166
pmid-9918973|pmid-3280462|NA|pmid-12008765
This system eventually led to the development of PRPBOT, which was designed specifically for transurethral resection of the prostate.
[ "8", "9", "10" ]
133
44,030
0
false
This system eventually led to the development of PRPBOT, which was designed specifically for transurethral resection of the prostate.
[]
This system eventually led to the development of PRPBOT, which was designed specifically for transurethral resection of the prostate.
true
true
true
true
true
7,615
1
DISCUSSION
1
8
[ "B8", "B9", "B10" ]
17,594,166
pmid-9918973|pmid-3280462|NA|pmid-12008765
ROBODOC, a robot system designed to machine the femur with greater precision in hip replacement surgeries,10 was the first surgical robot approved by the FDA.
[ "8", "9", "10" ]
158
44,031
0
false
ROBODOC, a robot system designed to machine the femur with greater precision in hip replacement surgeries,10 was the first surgical robot approved by the FDA.
[]
ROBODOC, a robot system designed to machine the femur with greater precision in hip replacement surgeries,10 was the first surgical robot approved by the FDA.
true
true
true
true
true
7,615
2
DISCUSSION
1
11
[ "B11", "B12" ]
17,594,166
pmid-10612764|pmid-9685550
Much intensive research on robot systems to develop telepresence surgery, and efforts to overcome the limitations produced by conventional laparoscopic surgery, eventually lead to the introduction of robotics into the surgical community.
[ "11", "12" ]
237
44,032
0
false
Much intensive research on robot systems to develop telepresence surgery, and efforts to overcome the limitations produced by conventional laparoscopic surgery, eventually lead to the introduction of robotics into the surgical community.
[]
Much intensive research on robot systems to develop telepresence surgery, and efforts to overcome the limitations produced by conventional laparoscopic surgery, eventually lead to the introduction of robotics into the surgical community.
true
true
true
true
true
7,616
2
DISCUSSION
1
11
[ "B11", "B12" ]
17,594,166
pmid-10612764|pmid-9685550
The Automated Endoscopic System for Optimal Positioning (AESOP), a robotic arm just for holding a laparoscopic camera controlled by a surgeon's voice command, was introduced and commercialized in the mid-1990s.
[ "11", "12" ]
210
44,033
0
false
The Automated Endoscopic System for Optimal Positioning (AESOP), a robotic arm just for holding a laparoscopic camera controlled by a surgeon's voice command, was introduced and commercialized in the mid-1990s.
[]
The Automated Endoscopic System for Optimal Positioning (AESOP), a robotic arm just for holding a laparoscopic camera controlled by a surgeon's voice command, was introduced and commercialized in the mid-1990s.
true
true
true
true
true
7,616
2
DISCUSSION
1
11
[ "B11", "B12" ]
17,594,166
pmid-10612764|pmid-9685550
Computer Motion, Inc. of Santa Barbara, CA developed and marketed a surgical robotic system (ZEUS) equipped with AEOSOP.11 Notably, Integrated Surgical System (now Intuitive Surgical) of Mountain View, CA, licensed the SRI Green Telepresence Surgery System, which was extensively redesigned and reintroduced as the curre...
[ "11", "12" ]
440
44,034
0
false
Computer Motion, Inc. of Santa Barbara, CA developed and marketed a surgical robotic system (ZEUS) equipped with AEOSOP.11 Notably, Integrated Surgical System (now Intuitive Surgical) of Mountain View, CA, licensed the SRI Green Telepresence Surgery System, which was extensively redesigned and reintroduced as the curre...
[]
Computer Motion, Inc. of Santa Barbara, CA developed and marketed a surgical robotic system (ZEUS) equipped with AEOSOP.11 Notably, Integrated Surgical System (now Intuitive Surgical) of Mountain View, CA, licensed the SRI Green Telepresence Surgery System, which was extensively redesigned and reintroduced as the curre...
true
true
true
true
true
7,616
2
DISCUSSION
1
11
[ "B11", "B12" ]
17,594,166
pmid-10612764|pmid-9685550
This system is unique in the current field of robotic surgery due to its great advantages over the ZEUS system.
[ "11", "12" ]
111
44,035
0
false
This system is unique in the current field of robotic surgery due to its great advantages over the ZEUS system.
[]
This system is unique in the current field of robotic surgery due to its great advantages over the ZEUS system.
true
true
true
true
true
7,616
2
DISCUSSION
1
11
[ "B11", "B12" ]
17,594,166
pmid-10612764|pmid-9685550
In 1997, Himpens et al.12 performed the first telemanipulative laparoscopic cholecystectomy with its use.
[ "11", "12" ]
105
44,036
0
false
In 1997, Himpens et al.12 performed the first telemanipulative laparoscopic cholecystectomy with its use.
[]
In 1997, Himpens et al.12 performed the first telemanipulative laparoscopic cholecystectomy with its use.
true
true
true
true
true
7,616
2
DISCUSSION
1
11
[ "B11", "B12" ]
17,594,166
pmid-10612764|pmid-9685550
In the US, the da Vinci system received FDA approval for general use in abdominal laparoscopic procedures in late July 2000, and Korean FDA approval was confirmed on July 13, 2005.
[ "11", "12" ]
180
44,037
0
false
In the US, the da Vinci system received FDA approval for general use in abdominal laparoscopic procedures in late July 2000, and Korean FDA approval was confirmed on July 13, 2005.
[]
In the US, the da Vinci system received FDA approval for general use in abdominal laparoscopic procedures in late July 2000, and Korean FDA approval was confirmed on July 13, 2005.
true
true
true
true
true
7,616
2
DISCUSSION
1
11
[ "B11", "B12" ]
17,594,166
pmid-10612764|pmid-9685550
Two days later, we performed the first case of telemanipulative laparoscopic cholecystectomy using the da Vinci in Korea.
[ "11", "12" ]
121
44,038
0
false
Two days later, we performed the first case of telemanipulative laparoscopic cholecystectomy using the da Vinci in Korea.
[]
Two days later, we performed the first case of telemanipulative laparoscopic cholecystectomy using the da Vinci in Korea.
true
true
true
true
true
7,616
3
DISCUSSION
0
null
null
17,594,166
null
The several serious limitations of conventional laparoscopic surgery are loss of dexterity, haptic feedback, natural hand-eye coordination (fulcrum effect), and movement based on a 2-D video monitor, which are all somewhat counterintuitive.
null
240
44,039
0
false
null
null
The several serious limitations of conventional laparoscopic surgery are loss of dexterity, haptic feedback, natural hand-eye coordination (fulcrum effect), and movement based on a 2-D video monitor, which are all somewhat counterintuitive.
true
true
true
true
true
7,617
3
DISCUSSION
0
null
null
17,594,166
null
Physiologic tremors in the surgeon are transmitted through the length of the rigid instrument.
null
94
44,040
0
false
null
null
Physiologic tremors in the surgeon are transmitted through the length of the rigid instrument.
true
true
true
true
true
7,617
3
DISCUSSION
0
null
null
17,594,166
null
Most laparoscopic gastrointestinal operations are difficult to learn, master, and perform routinely and surgeons have to face a long period of learning curve.
null
158
44,041
0
false
null
null
Most laparoscopic gastrointestinal operations are difficult to learn, master, and perform routinely and surgeons have to face a long period of learning curve.
true
true
true
true
true
7,617
3
DISCUSSION
0
null
null
17,594,166
null
Finally, poor ergonomic position for the surgeon is another problem for laparoscopic surgery.
null
93
44,042
0
false
null
null
Finally, poor ergonomic position for the surgeon is another problem for laparoscopic surgery.
true
true
true
true
true
7,617
3
DISCUSSION
0
null
null
17,594,166
null
These limitations make delicate dissection and anastomosis more difficult, if not impossible.
null
93
44,043
0
false
null
null
These limitations make delicate dissection and anastomosis more difficult, if not impossible.
true
true
true
true
true
7,617
3
DISCUSSION
0
null
null
17,594,166
null
However, the present da Vinci system was developed to overcome these problems.
null
78
44,044
0
false
null
null
However, the present da Vinci system was developed to overcome these problems.
true
true
true
true
true
7,617
3
DISCUSSION
0
null
null
17,594,166
null
One of the most outstanding points of the da Vinci system is that the tips of the laparoscopic equipment have seven degrees of freedom of motion, which means that the same exact movements as those of a human hand are possible.
null
226
44,045
0
false
null
null
One of the most outstanding points of the da Vinci system is that the tips of the laparoscopic equipment have seven degrees of freedom of motion, which means that the same exact movements as those of a human hand are possible.
true
true
true
true
true
7,617
3
DISCUSSION
0
null
null
17,594,166
null
Another sure advantage is the 3-D visualization of the operative field that the da Vinci system provides, compared to conventional minimally invasive procedures (Table 1).
null
171
44,046
0
false
null
null
Another sure advantage is the 3-D visualization of the operative field that the da Vinci system provides, compared to conventional minimally invasive procedures (Table 1).
true
true
true
true
true
7,617
4
DISCUSSION
0
null
null
17,594,166
null
However, there are limitations of robot-assisted surgery that need to be resolved, namely the long preparation time, high cost and complete absence of touch sensation.
null
167
44,047
0
false
null
null
However, there are limitations of robot-assisted surgery that need to be resolved, namely the long preparation time, high cost and complete absence of touch sensation.
true
true
true
true
true
7,618
4
DISCUSSION
0
null
null
17,594,166
null
In this case, it took about 40 minutes to prepare the system prior to surgery, but it is certain that preparation time will shorten with experience.
null
148
44,048
0
false
null
null
In this case, it took about 40 minutes to prepare the system prior to surgery, but it is certain that preparation time will shorten with experience.
true
true
true
true
true
7,618
4
DISCUSSION
0
null
null
17,594,166
null
The cost for robotic-assisted surgery ranges from about form 7 million to 15 million won($6,900 to $18,750; exchange rate $1.00 = 1035won, December 1, 2005), which is another obstacle to overcome in the popular application of this system for laparoscopic surgeries.
null
265
44,049
0
false
null
null
The cost for robotic-assisted surgery ranges from about form 7 million to 15 million won($6,900 to $18,750; exchange rate $1.00 = 1035won, December 1, 2005), which is another obstacle to overcome in the popular application of this system for laparoscopic surgeries.
true
true
true
true
true
7,618
5
DISCUSSION
1
13
[ "B13" ]
17,594,166
NA
Since 1987, laparoscopic cholecystectomy has been widely attempted in almost all medical centers.
[ "13" ]
97
44,050
0
false
Since 1987, laparoscopic cholecystectomy has been widely attempted in almost all medical centers.
[]
Since 1987, laparoscopic cholecystectomy has been widely attempted in almost all medical centers.
true
true
true
true
true
7,619
5
DISCUSSION
1
13
[ "B13" ]
17,594,166
NA
With the accumulation of laparoscopic experience in cholecystectomy, great advances of laparoscopic ability in the local anatomy around Calot's triangle made complete laparoscopic cholecystectomy possible (without help of a robotic surgical system).
[ "13" ]
249
44,051
0
false
With the accumulation of laparoscopic experience in cholecystectomy, great advances of laparoscopic ability in the local anatomy around Calot's triangle made complete laparoscopic cholecystectomy possible (without help of a robotic surgical system).
[]
With the accumulation of laparoscopic experience in cholecystectomy, great advances of laparoscopic ability in the local anatomy around Calot's triangle made complete laparoscopic cholecystectomy possible (without help of a robotic surgical system).
true
true
true
true
true
7,619
5
DISCUSSION
1
13
[ "B13" ]
17,594,166
NA
In terms of cost-effectiveness, the da Vinci robot system is not suitable for cholecystectomy and does not provide any additional value to surgeons or patients.
[ "13" ]
160
44,052
0
false
In terms of cost-effectiveness, the da Vinci robot system is not suitable for cholecystectomy and does not provide any additional value to surgeons or patients.
[]
In terms of cost-effectiveness, the da Vinci robot system is not suitable for cholecystectomy and does not provide any additional value to surgeons or patients.
true
true
true
true
true
7,619
5
DISCUSSION
1
13
[ "B13" ]
17,594,166
NA
However, taking this system's several critical advantages over conventional laparoscopic surgery into consideration; its value may be realized in cases of more complex gallstone disease, such as Mirrz syndrome.
[ "13" ]
210
44,053
0
false
However, taking this system's several critical advantages over conventional laparoscopic surgery into consideration; its value may be realized in cases of more complex gallstone disease, such as Mirrz syndrome.
[]
However, taking this system's several critical advantages over conventional laparoscopic surgery into consideration; its value may be realized in cases of more complex gallstone disease, such as Mirrz syndrome.
true
true
true
true
true
7,619
5
DISCUSSION
1
13
[ "B13" ]
17,594,166
NA
It has the potential to reduce the incidence of accidental and unexpected injury to surrounding organs during laparoscopic cholecystectomy, including to the bile duct, bowel and major vascular structures because of the robot's providing better visual image and precise movements.
[ "13" ]
279
44,054
0
false
It has the potential to reduce the incidence of accidental and unexpected injury to surrounding organs during laparoscopic cholecystectomy, including to the bile duct, bowel and major vascular structures because of the robot's providing better visual image and precise movements.
[]
It has the potential to reduce the incidence of accidental and unexpected injury to surrounding organs during laparoscopic cholecystectomy, including to the bile duct, bowel and major vascular structures because of the robot's providing better visual image and precise movements.
true
true
true
true
true
7,619
5
DISCUSSION
1
13
[ "B13" ]
17,594,166
NA
Furthermore, laparoscopic cholecystectomy using the da Vinci system can be regarded as an ideal teaching tool for both surgeons just starting to learn robotic-assisted surgery and residents who will most likely have this technology as a standard procedure in their future careers.13
[ "13" ]
282
44,055
0
false
Furthermore, laparoscopic cholecystectomy using the da Vinci system can be regarded as an ideal teaching tool for both surgeons just starting to learn robotic-assisted surgery and residents who will most likely have this technology as a standard procedure in their future careers.13
[]
Furthermore, laparoscopic cholecystectomy using the da Vinci system can be regarded as an ideal teaching tool for both surgeons just starting to learn robotic-assisted surgery and residents who will most likely have this technology as a standard procedure in their future careers.13
true
true
false
true
false
7,619
6
DISCUSSION
0
null
null
17,594,166
null
In order to properly establish this robotic-assisted surgery in one institution, we would like to emphasize the need for not only surgeons but also scrub nurses to be trained and educated as part of a "Robot Team."
null
214
44,056
0
false
null
null
In order to properly establish this robotic-assisted surgery in one institution, we would like to emphasize the need for not only surgeons but also scrub nurses to be trained and educated as part of a "Robot Team."
true
true
false
true
false
7,620
6
DISCUSSION
0
null
null
17,594,166
null
Surgeons need to become well aware of the differences in robot-assisted surgery from conventional laparoscopic surgery.
null
119
44,057
0
false
null
null
Surgeons need to become well aware of the differences in robot-assisted surgery from conventional laparoscopic surgery.
true
true
true
true
true
7,620
6
DISCUSSION
0
null
null
17,594,166
null
All team members should learn how to connect the robotic arms to each trocar how to connect instruments to the robotic arms, how to disconnect the arms and how to adjust the arms to respective trocar sites when needed.
null
218
44,058
0
false
null
null
All team members should learn how to connect the robotic arms to each trocar how to connect instruments to the robotic arms, how to disconnect the arms and how to adjust the arms to respective trocar sites when needed.
true
true
true
true
true
7,620
6
DISCUSSION
0
null
null
17,594,166
null
Through virtual reality training prior to actual intervention, all members can discuss issues that need to be corrected and become more familiar with the robot system.
null
167
44,059
0
false
null
null
Through virtual reality training prior to actual intervention, all members can discuss issues that need to be corrected and become more familiar with the robot system.
true
true
true
true
true
7,620
6
DISCUSSION
0
null
null
17,594,166
null
In our case, three experienced laparoscopic surgeons and two nurses specially chosen for robot surgery participated in the educational programs provided by Intuitive Surgical Inc. in the US.
null
190
44,060
0
false
null
null
In our case, three experienced laparoscopic surgeons and two nurses specially chosen for robot surgery participated in the educational programs provided by Intuitive Surgical Inc. in the US.
true
true
true
true
true
7,620
6
DISCUSSION
0
null
null
17,594,166
null
They educated other team members in Korea by performing several simulated operations using the da Vinci system.
null
111
44,061
0
false
null
null
They educated other team members in Korea by performing several simulated operations using the da Vinci system.
true
true
true
true
true
7,620
6
DISCUSSION
0
null
null
17,594,166
null
This direct and indirect experiences with robot- assisted surgery is likely to be of great aid to understanding the system and achieving successful first laparoscopic cholecystectomies.
null
185
44,062
0
false
null
null
This direct and indirect experiences with robot- assisted surgery is likely to be of great aid to understanding the system and achieving successful first laparoscopic cholecystectomies.
true
true
true
true
true
7,620
7
DISCUSSION
0
null
null
17,594,166
null
From the end of July 2005 to the end of this year, more than twenty surgeries using the da Vinci system were performed at our institution, including cholecystectomy, correction of choledochal cyst, gastrectomy, prostatectomy, partial bladder excision, and excision of a mediastinal tumor.
null
288
44,063
0
false
null
null
From the end of July 2005 to the end of this year, more than twenty surgeries using the da Vinci system were performed at our institution, including cholecystectomy, correction of choledochal cyst, gastrectomy, prostatectomy, partial bladder excision, and excision of a mediastinal tumor.
true
true
true
true
true
7,621
7
DISCUSSION
0
null
null
17,594,166
null
According to our early experiences, the 3-D visualization and seven degrees of motion of the laparoscopic equipment have definitively provided more precision in delicate laparoscopic procedures, especially when dissecting soft tissues around major vessels, performing hepaticojejunostomy, and maneuvering in narrow space...
null
345
44,064
0
false
null
null
According to our early experiences, the 3-D visualization and seven degrees of motion of the laparoscopic equipment have definitively provided more precision in delicate laparoscopic procedures, especially when dissecting soft tissues around major vessels, performing hepaticojejunostomy, and maneuvering in narrow space...
true
true
true
true
true
7,621
7
DISCUSSION
0
null
null
17,594,166
null
We are preparing a report of the preliminary our early experiences with laparoscopic surgery using the da Vinci system.
null
119
44,065
0
false
null
null
We are preparing a report of the preliminary our early experiences with laparoscopic surgery using the da Vinci system.
true
true
true
true
true
7,621
8
DISCUSSION
1
14
[ "B14", "B17" ]
17,594,166
pmid-11984681|NA
In summary, due to advancements in robotic technology, the first Korean robot-assisted laparoscopic cholecystectomy was performed in the Yonsei University Medical Center.
[ "14", "17" ]
170
44,066
0
false
In summary, due to advancements in robotic technology, the first Korean robot-assisted laparoscopic cholecystectomy was performed in the Yonsei University Medical Center.
[]
In summary, due to advancements in robotic technology, the first Korean robot-assisted laparoscopic cholecystectomy was performed in the Yonsei University Medical Center.
true
true
true
true
true
7,622
8
DISCUSSION
1
14
[ "B14", "B17" ]
17,594,166
pmid-11984681|NA
The feasibility of the da Vinci system has been shown in accordance with our early experiences.14-17 This telemanipulative robotic system has the potential to expand surgical treatment modalities beyond the limits of human ability.
[ "14", "17" ]
231
44,067
0
false
The feasibility of the da Vinci system has been shown in accordance with our early experiences.14-17 This telemanipulative robotic system has the potential to expand surgical treatment modalities beyond the limits of human ability.
[]
The feasibility of the da Vinci system has been shown in accordance with our early experiences.14-17 This telemanipulative robotic system has the potential to expand surgical treatment modalities beyond the limits of human ability.
true
true
true
true
true
7,622
8
DISCUSSION
1
14
[ "B14", "B17" ]
17,594,166
pmid-11984681|NA
Further trials of robot-assisted surgery are needed in our country and research on evaluating both the efficacy and safety of the procedure as well.
[ "14", "17" ]
148
44,068
0
false
Further trials of robot-assisted surgery are needed in our country and research on evaluating both the efficacy and safety of the procedure as well.
[]
Further trials of robot-assisted surgery are needed in our country and research on evaluating both the efficacy and safety of the procedure as well.
true
true
true
true
true
7,622
0
DISCUSSION
1
11
[ "B11", "B19", "B12", "B20", "B9", "B13", "B21" ]
19,188,428
pmid-16091482|pmid-12714324|pmid-15933859|pmid-18959829|pmid-8288042|pmid-19056571|pmid-8902315
It has long been recognized that energy-restricted diets and physical training both exert sympathoinhibitory effects as well as improving the metabolic profile of subjects with metabolic syndrome (11,19).
[ "11", "19", "12", "20", "9", "13", "21" ]
204
44,069
0
false
It has long been recognized that energy-restricted diets and physical training both exert sympathoinhibitory effects as well as improving the metabolic profile of subjects with metabolic syndrome.
[ "11,19" ]
It has long been recognized that energy-restricted diets and physical training both exert sympathoinhibitory effects as well as improving the metabolic profile of subjects with metabolic syndrome.
true
true
true
true
true
7,623
0
DISCUSSION
1
11
[ "B11", "B19", "B12", "B20", "B9", "B13", "B21" ]
19,188,428
pmid-16091482|pmid-12714324|pmid-15933859|pmid-18959829|pmid-8288042|pmid-19056571|pmid-8902315
As such, these lifestyle interventions are recommended as first-line treatments for the metabolic syndrome, a condition that is characterized by sympathetic overactivity (12,20).
[ "11", "19", "12", "20", "9", "13", "21" ]
178
44,070
0
false
As such, these lifestyle interventions are recommended as first-line treatments for the metabolic syndrome, a condition that is characterized by sympathetic overactivity.
[ "12,20" ]
As such, these lifestyle interventions are recommended as first-line treatments for the metabolic syndrome, a condition that is characterized by sympathetic overactivity.
true
true
true
true
true
7,623
0
DISCUSSION
1
11
[ "B11", "B19", "B12", "B20", "B9", "B13", "B21" ]
19,188,428
pmid-16091482|pmid-12714324|pmid-15933859|pmid-18959829|pmid-8288042|pmid-19056571|pmid-8902315
The novel finding of the present study is that weight loss by consumption of a hypocaloric diet with or without exercise not only lowers resting sympathetic drive but also reverses the blunted sympathetic responsiveness to glucose ingestion that has been reported in the obese state.
[ "11", "19", "12", "20", "9", "13", "21" ]
283
44,071
0
false
The novel finding of the present study is that weight loss by consumption of a hypocaloric diet with or without exercise not only lowers resting sympathetic drive but also reverses the blunted sympathetic responsiveness to glucose ingestion that has been reported in the obese state.
[]
The novel finding of the present study is that weight loss by consumption of a hypocaloric diet with or without exercise not only lowers resting sympathetic drive but also reverses the blunted sympathetic responsiveness to glucose ingestion that has been reported in the obese state.
true
true
true
true
true
7,623
0
DISCUSSION
1
11
[ "B11", "B19", "B12", "B20", "B9", "B13", "B21" ]
19,188,428
pmid-16091482|pmid-12714324|pmid-15933859|pmid-18959829|pmid-8288042|pmid-19056571|pmid-8902315
In agreement with previously published data (9,13,21), our study shows that blunted stimulation of the norepinephrine appearance rate is most pronounced in insulin-resistant subjects.
[ "11", "19", "12", "20", "9", "13", "21" ]
183
44,072
0
false
In agreement with previously published data, our study shows that blunted stimulation of the norepinephrine appearance rate is most pronounced in insulin-resistant subjects.
[ "9,13,21" ]
In agreement with previously published data, our study shows that blunted stimulation of the norepinephrine appearance rate is most pronounced in insulin-resistant subjects.
true
true
true
true
true
7,623
0
DISCUSSION
1
11
[ "B11", "B19", "B12", "B20", "B9", "B13", "B21" ]
19,188,428
pmid-16091482|pmid-12714324|pmid-15933859|pmid-18959829|pmid-8288042|pmid-19056571|pmid-8902315
In turn, insulin-resistant subjects experienced the greatest increase in sympathetic responsiveness after weight loss, despite comparable weight loss in the insulin-sensitive group.
[ "11", "19", "12", "20", "9", "13", "21" ]
181
44,073
0
false
In turn, insulin-resistant subjects experienced the greatest increase in sympathetic responsiveness after weight loss, despite comparable weight loss in the insulin-sensitive group.
[]
In turn, insulin-resistant subjects experienced the greatest increase in sympathetic responsiveness after weight loss, despite comparable weight loss in the insulin-sensitive group.
true
true
true
true
true
7,623
0
DISCUSSION
1
11
[ "B11", "B19", "B12", "B20", "B9", "B13", "B21" ]
19,188,428
pmid-16091482|pmid-12714324|pmid-15933859|pmid-18959829|pmid-8288042|pmid-19056571|pmid-8902315
Correlation analysis showed that reductions in body weight, central adiposity, and plasma leptin levels were most strongly associated with the increase in the SNS response for a given level of plasma insulin.
[ "11", "19", "12", "20", "9", "13", "21" ]
208
44,074
0
false
Correlation analysis showed that reductions in body weight, central adiposity, and plasma leptin levels were most strongly associated with the increase in the SNS response for a given level of plasma insulin.
[]
Correlation analysis showed that reductions in body weight, central adiposity, and plasma leptin levels were most strongly associated with the increase in the SNS response for a given level of plasma insulin.
true
true
true
true
true
7,623
1
DISCUSSION
1
22
[ "B22", "B5", "B23", "B24", "B25", "B26", "B27" ]
19,188,428
pmid-9455932|pmid-10528643|pmid-1397783|pmid-16951936|pmid-2199946|pmid-10969837|pmid-16154436
What mechanisms may underlie these changes in SNS responsiveness?
[ "22", "5", "23", "24", "25", "26", "27" ]
65
44,075
0
false
What mechanisms may underlie these changes in SNS responsiveness?
[]
What mechanisms may underlie these changes in SNS responsiveness?
true
true
true
true
true
7,624
1
DISCUSSION
1
22
[ "B22", "B5", "B23", "B24", "B25", "B26", "B27" ]
19,188,428
pmid-9455932|pmid-10528643|pmid-1397783|pmid-16951936|pmid-2199946|pmid-10969837|pmid-16154436
Despite increasing evidence for a pathophysiological role of insulin-mediated sympathoexcitation, the mechanisms and sites through which insulin increases SNS activity remain to be fully elucidated.
[ "22", "5", "23", "24", "25", "26", "27" ]
198
44,076
0
false
Despite increasing evidence for a pathophysiological role of insulin-mediated sympathoexcitation, the mechanisms and sites through which insulin increases SNS activity remain to be fully elucidated.
[]
Despite increasing evidence for a pathophysiological role of insulin-mediated sympathoexcitation, the mechanisms and sites through which insulin increases SNS activity remain to be fully elucidated.
true
true
true
true
true
7,624
1
DISCUSSION
1
22
[ "B22", "B5", "B23", "B24", "B25", "B26", "B27" ]
19,188,428
pmid-9455932|pmid-10528643|pmid-1397783|pmid-16951936|pmid-2199946|pmid-10969837|pmid-16154436
Circulating insulin reaches the central nervous system via a saturable, active transport process across the blood-brain barrier.
[ "22", "5", "23", "24", "25", "26", "27" ]
128
44,077
0
false
Circulating insulin reaches the central nervous system via a saturable, active transport process across the blood-brain barrier.
[]
Circulating insulin reaches the central nervous system via a saturable, active transport process across the blood-brain barrier.
true
true
true
true
true
7,624
1
DISCUSSION
1
22
[ "B22", "B5", "B23", "B24", "B25", "B26", "B27" ]
19,188,428
pmid-9455932|pmid-10528643|pmid-1397783|pmid-16951936|pmid-2199946|pmid-10969837|pmid-16154436
Insulin receptors are widely distributed in the human brain in several distinct regions, including the hypothalamus (mainly arcuate nucleus), cerebral cortex, and cerebellum (22).
[ "22", "5", "23", "24", "25", "26", "27" ]
179
44,078
1
false
Insulin receptors are widely distributed in the human brain in several distinct regions, including the hypothalamus (mainly arcuate nucleus), cerebral cortex, and cerebellum.
[ "22" ]
Insulin receptors are widely distributed in the human brain in several distinct regions, including the hypothalamus (mainly arcuate nucleus), cerebral cortex, and cerebellum.
true
true
true
true
true
7,624
1
DISCUSSION
1
5
[ "B22", "B5", "B23", "B24", "B25", "B26", "B27" ]
19,188,428
pmid-9455932|pmid-10528643|pmid-1397783|pmid-16951936|pmid-2199946|pmid-10969837|pmid-16154436
In a series of rodent experiments, Muntzel (5) demonstrated that intracerebroventricular insulin infusion evoked acute increases in lumbar sympathetic nerve activity, an effect that was abolished by anteroventral third ventricle lesioning.
[ "22", "5", "23", "24", "25", "26", "27" ]
239
44,079
1
false
In a series of rodent experiments, Muntzel demonstrated that intracerebroventricular insulin infusion evoked acute increases in lumbar sympathetic nerve activity, an effect that was abolished by anteroventral third ventricle lesioning.
[ "5" ]
In a series of rodent experiments, Muntzel demonstrated that intracerebroventricular insulin infusion evoked acute increases in lumbar sympathetic nerve activity, an effect that was abolished by anteroventral third ventricle lesioning.
true
true
true
true
true
7,624
1
DISCUSSION
1
23
[ "B22", "B5", "B23", "B24", "B25", "B26", "B27" ]
19,188,428
pmid-9455932|pmid-10528643|pmid-1397783|pmid-16951936|pmid-2199946|pmid-10969837|pmid-16154436
In healthy humans, euglycemic hyperinsulinemia in the postprandial range increases MSNA, which is consistent with the concept that insulin stimulates central sympathetic outflow (23).
[ "22", "5", "23", "24", "25", "26", "27" ]
183
44,080
1
false
In healthy humans, euglycemic hyperinsulinemia in the postprandial range increases MSNA, which is consistent with the concept that insulin stimulates central sympathetic outflow.
[ "23" ]
In healthy humans, euglycemic hyperinsulinemia in the postprandial range increases MSNA, which is consistent with the concept that insulin stimulates central sympathetic outflow.
true
true
true
true
true
7,624
1
DISCUSSION
1
22
[ "B22", "B5", "B23", "B24", "B25", "B26", "B27" ]
19,188,428
pmid-9455932|pmid-10528643|pmid-1397783|pmid-16951936|pmid-2199946|pmid-10969837|pmid-16154436
Impaired blood-to-brain transport of insulin may be one mechanism contributing to the blunted sympathetic responses to glucose in obese insulin-resistant subjects.
[ "22", "5", "23", "24", "25", "26", "27" ]
163
44,081
0
false
Impaired blood-to-brain transport of insulin may be one mechanism contributing to the blunted sympathetic responses to glucose in obese insulin-resistant subjects.
[]
Impaired blood-to-brain transport of insulin may be one mechanism contributing to the blunted sympathetic responses to glucose in obese insulin-resistant subjects.
true
true
true
true
true
7,624
1
DISCUSSION
1
24
[ "B22", "B5", "B23", "B24", "B25", "B26", "B27" ]
19,188,428
pmid-9455932|pmid-10528643|pmid-1397783|pmid-16951936|pmid-2199946|pmid-10969837|pmid-16154436
A reduced cerebrospinal fluid–to-plasma insulin ratio has recently been reported with increasing BMI and HOMA-IR index, suggesting that obesity in humans is characterized by a relative central nervous system insulin deficit (24).
[ "22", "5", "23", "24", "25", "26", "27" ]
229
44,082
1
false
A reduced cerebrospinal fluid–to-plasma insulin ratio has recently been reported with increasing BMI and HOMA-IR index, suggesting that obesity in humans is characterized by a relative central nervous system insulin deficit.
[ "24" ]
A reduced cerebrospinal fluid–to-plasma insulin ratio has recently been reported with increasing BMI and HOMA-IR index, suggesting that obesity in humans is characterized by a relative central nervous system insulin deficit.
true
true
true
true
true
7,624
1
DISCUSSION
1
25
[ "B22", "B5", "B23", "B24", "B25", "B26", "B27" ]
19,188,428
pmid-9455932|pmid-10528643|pmid-1397783|pmid-16951936|pmid-2199946|pmid-10969837|pmid-16154436
These data are supported by findings in genetically obese rats, which exhibit reduced brain capillary insulin binding compared with lean rats (25).
[ "22", "5", "23", "24", "25", "26", "27" ]
147
44,083
1
false
These data are supported by findings in genetically obese rats, which exhibit reduced brain capillary insulin binding compared with lean rats.
[ "25" ]
These data are supported by findings in genetically obese rats, which exhibit reduced brain capillary insulin binding compared with lean rats.
true
true
true
true
true
7,624
1
DISCUSSION
1
26
[ "B22", "B5", "B23", "B24", "B25", "B26", "B27" ]
19,188,428
pmid-9455932|pmid-10528643|pmid-1397783|pmid-16951936|pmid-2199946|pmid-10969837|pmid-16154436
Reduced insulin delivery into the brain has also been demonstrated in canine models of insulin resistance, induced by high fat feeding or dexamethasone administration (26).
[ "22", "5", "23", "24", "25", "26", "27" ]
172
44,084
1
false
Reduced insulin delivery into the brain has also been demonstrated in canine models of insulin resistance, induced by high fat feeding or dexamethasone administration.
[ "26" ]
Reduced insulin delivery into the brain has also been demonstrated in canine models of insulin resistance, induced by high fat feeding or dexamethasone administration.
true
true
true
true
true
7,624
1
DISCUSSION
1
22
[ "B22", "B5", "B23", "B24", "B25", "B26", "B27" ]
19,188,428
pmid-9455932|pmid-10528643|pmid-1397783|pmid-16951936|pmid-2199946|pmid-10969837|pmid-16154436
To date, there are limited data on the benefits of reversing central insulin resistance by therapeutic interventions.
[ "22", "5", "23", "24", "25", "26", "27" ]
117
44,085
0
false
To date, there are limited data on the benefits of reversing central insulin resistance by therapeutic interventions.
[]
To date, there are limited data on the benefits of reversing central insulin resistance by therapeutic interventions.
true
true
true
true
true
7,624
1
DISCUSSION
1
27
[ "B22", "B5", "B23", "B24", "B25", "B26", "B27" ]
19,188,428
pmid-9455932|pmid-10528643|pmid-1397783|pmid-16951936|pmid-2199946|pmid-10969837|pmid-16154436
Intranasal administration of insulin, which enables a direct delivery of peptide to the brain without substantial absorption into the blood stream, has been shown to acutely raise blood pressure but not muscle sympathetic nerve activity in healthy subjects (27).
[ "22", "5", "23", "24", "25", "26", "27" ]
262
44,086
1
false
Intranasal administration of insulin, which enables a direct delivery of peptide to the brain without substantial absorption into the blood stream, has been shown to acutely raise blood pressure but not muscle sympathetic nerve activity in healthy subjects.
[ "27" ]
Intranasal administration of insulin, which enables a direct delivery of peptide to the brain without substantial absorption into the blood stream, has been shown to acutely raise blood pressure but not muscle sympathetic nerve activity in healthy subjects.
true
true
true
true
true
7,624
2
DISCUSSION
1
8
[ "B8", "B19", "B28", "B29" ]
19,188,428
pmid-8200969|pmid-12714324|pmid-18504322|NA
An alternative explanation of our findings is that weight loss may have improved insulin-induced vasodilation in skeletal muscle, thus eliciting greater baroreflex-mediated increases in SNS activity postglucose.
[ "8", "19", "28", "29" ]
211
44,087
0
false
An alternative explanation of our findings is that weight loss may have improved insulin-induced vasodilation in skeletal muscle, thus eliciting greater baroreflex-mediated increases in SNS activity postglucose.
[]
An alternative explanation of our findings is that weight loss may have improved insulin-induced vasodilation in skeletal muscle, thus eliciting greater baroreflex-mediated increases in SNS activity postglucose.
true
true
true
true
true
7,625
2
DISCUSSION
1
8
[ "B8", "B19", "B28", "B29" ]
19,188,428
pmid-8200969|pmid-12714324|pmid-18504322|NA
Blunted vasodilatory responses to insulin have been previously reported in obese compared with lean humans (8) and attributed to impaired release of endothelium-derived mediators.
[ "8", "19", "28", "29" ]
179
44,088
1
false
Blunted vasodilatory responses to insulin have been previously reported in obese compared with lean humans and attributed to impaired release of endothelium-derived mediators.
[ "8" ]
Blunted vasodilatory responses to insulin have been previously reported in obese compared with lean humans and attributed to impaired release of endothelium-derived mediators.
true
true
true
true
true
7,625
2
DISCUSSION
1
8
[ "B8", "B19", "B28", "B29" ]
19,188,428
pmid-8200969|pmid-12714324|pmid-18504322|NA
Weight loss alone or together with exercise improves conduit and resistance artery endothelial function in obese adults (19,28).
[ "8", "19", "28", "29" ]
128
44,089
0
false
Weight loss alone or together with exercise improves conduit and resistance artery endothelial function in obese adults.
[ "19,28" ]
Weight loss alone or together with exercise improves conduit and resistance artery endothelial function in obese adults.
true
true
true
true
true
7,625
2
DISCUSSION
1
8
[ "B8", "B19", "B28", "B29" ]
19,188,428
pmid-8200969|pmid-12714324|pmid-18504322|NA
In the present study, baseline calf blood flow was inversely related to whole-body norepinephrine spillover; however, calf blood flow responses to endogenous insulin did not increase after weight loss.
[ "8", "19", "28", "29" ]
201
44,090
0
false
In the present study, baseline calf blood flow was inversely related to whole-body norepinephrine spillover; however, calf blood flow responses to endogenous insulin did not increase after weight loss.
[]
In the present study, baseline calf blood flow was inversely related to whole-body norepinephrine spillover; however, calf blood flow responses to endogenous insulin did not increase after weight loss.
true
true
true
true
true
7,625
2
DISCUSSION
1
29
[ "B8", "B19", "B28", "B29" ]
19,188,428
pmid-8200969|pmid-12714324|pmid-18504322|NA
Similarly, the increase in heart rate postglucose that purportedly represents an insulin-mediated cardiac vagal withdrawal and/or increased cardiac sympathetic outflow (29) was not influenced by weight loss.
[ "8", "19", "28", "29" ]
207
44,091
1
false
Similarly, the increase in heart rate postglucose that purportedly represents an insulin-mediated cardiac vagal withdrawal and/or increased cardiac sympathetic outflow was not influenced by weight loss.
[ "29" ]
Similarly, the increase in heart rate postglucose that purportedly represents an insulin-mediated cardiac vagal withdrawal and/or increased cardiac sympathetic outflow was not influenced by weight loss.
true
true
true
true
true
7,625
3
DISCUSSION
1
30
[ "B30", "B31", "B32" ]
19,188,428
pmid-15752952|NA|pmid-12609005
Leptin concentrations were not acutely altered by glucose ingestion at baseline or after weight loss in either subgroup, which concurs with a study in insulin-resistant Japanese men (30) but not with another study conducted in obese women, which showed an elevation in leptin at times 30 and 60 min postglucose (31).
[ "30", "31", "32" ]
316
44,092
1
false
Leptin concentrations were not acutely altered by glucose ingestion at baseline or after weight loss in either subgroup, which concurs with a study in insulin-resistant Japanese men but not with another study conducted in obese women, which showed an elevation in leptin at times 30 and 60 min postglucose.
[ "30", "31" ]
Leptin concentrations were not acutely altered by glucose ingestion at baseline or after weight loss in either subgroup, which concurs with a study in insulin-resistant Japanese men but not with another study conducted in obese women, which showed an elevation in leptin at times 30 and 60 min postglucose.
true
true
true
true
true
7,626
3
DISCUSSION
1
32
[ "B30", "B31", "B32" ]
19,188,428
pmid-15752952|NA|pmid-12609005
In rodents, leptin administration produces regional sympathetic activation, and, conversely, sympathoadrenal stimulation inhibits leptin expression and secretion from adipose tissue (32).
[ "30", "31", "32" ]
187
44,093
1
false
In rodents, leptin administration produces regional sympathetic activation, and, conversely, sympathoadrenal stimulation inhibits leptin expression and secretion from adipose tissue.
[ "32" ]
In rodents, leptin administration produces regional sympathetic activation, and, conversely, sympathoadrenal stimulation inhibits leptin expression and secretion from adipose tissue.
true
true
true
true
true
7,626
3
DISCUSSION
1
30
[ "B30", "B31", "B32" ]
19,188,428
pmid-15752952|NA|pmid-12609005
The inverse relationships between resting plasma leptin levels and the norepinephrine spillover response at baseline and between the fall in plasma leptin levels after weight loss and the increase in plasma norepinephrine response suggests that adiposity, insulin resistance, and leptin may all modulate sympathetic resp...
[ "30", "31", "32" ]
354
44,094
0
false
The inverse relationships between resting plasma leptin levels and the norepinephrine spillover response at baseline and between the fall in plasma leptin levels after weight loss and the increase in plasma norepinephrine response suggests that adiposity, insulin resistance, and leptin may all modulate sympathetic resp...
[]
The inverse relationships between resting plasma leptin levels and the norepinephrine spillover response at baseline and between the fall in plasma leptin levels after weight loss and the increase in plasma norepinephrine response suggests that adiposity, insulin resistance, and leptin may all modulate sympathetic resp...
true
true
true
true
true
7,626
4
DISCUSSION
1
33
[ "B33" ]
19,188,428
pmid-16246040
In summary, the present study demonstrates a hitherto unrecognized benefit of weight loss: the reversal of blunted sympathetic responsiveness to glucose ingestion in insulin-resistant subjects with metabolic syndrome.
[ "33" ]
217
44,095
0
false
In summary, the present study demonstrates a hitherto unrecognized benefit of weight loss: the reversal of blunted sympathetic responsiveness to glucose ingestion in insulin-resistant subjects with metabolic syndrome.
[]
In summary, the present study demonstrates a hitherto unrecognized benefit of weight loss: the reversal of blunted sympathetic responsiveness to glucose ingestion in insulin-resistant subjects with metabolic syndrome.
true
true
true
true
true
7,627
4
DISCUSSION
1
33
[ "B33" ]
19,188,428
pmid-16246040
Our data suggest that the improvement in central insulin resistance, rather than the peripheral vasodilatory response to insulin, mediated the increased sympathetic response to glucose.
[ "33" ]
185
44,096
0
false
Our data suggest that the improvement in central insulin resistance, rather than the peripheral vasodilatory response to insulin, mediated the increased sympathetic response to glucose.
[]
Our data suggest that the improvement in central insulin resistance, rather than the peripheral vasodilatory response to insulin, mediated the increased sympathetic response to glucose.
true
true
true
true
true
7,627
4
DISCUSSION
1
33
[ "B33" ]
19,188,428
pmid-16246040
Hypothalamic insulin signaling is important in initiating a catabolic response, including reduction in food intake and increase in energy expenditure.
[ "33" ]
150
44,097
0
false
Hypothalamic insulin signaling is important in initiating a catabolic response, including reduction in food intake and increase in energy expenditure.
[]
Hypothalamic insulin signaling is important in initiating a catabolic response, including reduction in food intake and increase in energy expenditure.
true
true
true
true
true
7,627
4
DISCUSSION
1
33
[ "B33" ]
19,188,428
pmid-16246040
Approximately one-third of the thermic effect of food can be accounted for by the meal-induced increment in SNS activity.
[ "33" ]
121
44,098
0
false
Approximately one-third of the thermic effect of food can be accounted for by the meal-induced increment in SNS activity.
[]
Approximately one-third of the thermic effect of food can be accounted for by the meal-induced increment in SNS activity.
true
true
true
true
true
7,627
4
DISCUSSION
1
33
[ "B33" ]
19,188,428
pmid-16246040
Therefore, improvements in central insulin resistance and sympathetic responsiveness to food intake would be expected to have beneficial effects on energy expenditure and body weight homeostasis.
[ "33" ]
195
44,099
0
false
Therefore, improvements in central insulin resistance and sympathetic responsiveness to food intake would be expected to have beneficial effects on energy expenditure and body weight homeostasis.
[]
Therefore, improvements in central insulin resistance and sympathetic responsiveness to food intake would be expected to have beneficial effects on energy expenditure and body weight homeostasis.
true
true
true
true
true
7,627
4
DISCUSSION
1
33
[ "B33" ]
19,188,428
pmid-16246040
Further intervention trials using insulin-sensitizing agents are needed to confirm the role of central insulin resistance in mediating blunted sympathetic responsiveness in metabolic syndrome obesity.
[ "33" ]
200
44,100
0
false
Further intervention trials using insulin-sensitizing agents are needed to confirm the role of central insulin resistance in mediating blunted sympathetic responsiveness in metabolic syndrome obesity.
[]
Further intervention trials using insulin-sensitizing agents are needed to confirm the role of central insulin resistance in mediating blunted sympathetic responsiveness in metabolic syndrome obesity.
true
true
true
true
true
7,627
4
DISCUSSION
1
33
[ "B33" ]
19,188,428
pmid-16246040
Intranasal insulin delivery may offer another therapeutic avenue (33) to test whether manipulating brain insulin levels affects SNS function in this clinical setting.
[ "33" ]
166
44,101
1
false
Intranasal insulin delivery may offer another therapeutic avenue to test whether manipulating brain insulin levels affects SNS function in this clinical setting.
[ "33" ]
Intranasal insulin delivery may offer another therapeutic avenue to test whether manipulating brain insulin levels affects SNS function in this clinical setting.
true
true
true
true
true
7,627
0
DISCUSSION
1
2
[ "B2", "B1" ]
20,552,078
pmid-12589636|pmid-17084977
CRPS is a chronic pain syndrome of which the pathophysiology is revealed clearly.
[ "2", "1" ]
81
44,102
0
false
CRPS is a chronic pain syndrome of which the pathophysiology is revealed clearly.
[]
CRPS is a chronic pain syndrome of which the pathophysiology is revealed clearly.
true
true
true
true
true
7,628
0
DISCUSSION
1
2
[ "B2", "B1" ]
20,552,078
pmid-12589636|pmid-17084977
However, the peripheral nervous system disorder accompanying the inflammation and ischemia take part in the pathophysiology and dysfunction of the central nervous system and sympathetic nervous system as well.
[ "2", "1" ]
209
44,103
0
false
However, the peripheral nervous system disorder accompanying the inflammation and ischemia take part in the pathophysiology and dysfunction of the central nervous system and sympathetic nervous system as well.
[]
However, the peripheral nervous system disorder accompanying the inflammation and ischemia take part in the pathophysiology and dysfunction of the central nervous system and sympathetic nervous system as well.
true
true
true
true
true
7,628
0
DISCUSSION
1
2
[ "B2", "B1" ]
20,552,078
pmid-12589636|pmid-17084977
Responses to the same treatment may be different as the symptoms, in the same patient it can be different other times [2].
[ "2", "1" ]
122
44,104
1
false
Responses to the same treatment may be different as the symptoms, in the same patient it can be different other times.
[ "2" ]
Responses to the same treatment may be different as the symptoms, in the same patient it can be different other times.
true
true
true
true
true
7,628
0
DISCUSSION
1
1
[ "B2", "B1" ]
20,552,078
pmid-12589636|pmid-17084977
Therefore, various treatments should be tried according to the physician's knowledge and experience, and taking into consideration patient's pain character and emotional stress and general health, as there is no typical treatment to for CRPS patients [1].
[ "2", "1" ]
255
44,105
1
false
Therefore, various treatments should be tried according to the physician's knowledge and experience, and taking into consideration patient's pain character and emotional stress and general health, as there is no typical treatment to for CRPS patients.
[ "1" ]
Therefore, various treatments should be tried according to the physician's knowledge and experience, and taking into consideration patient's pain character and emotional stress and general health, as there is no typical treatment to for CRPS patients.
true
true
true
true
true
7,628
1
DISCUSSION
1
3
[ "B3", "B4", "B5" ]
20,552,078
pmid-9647459|pmid-16772799|NA
The objects of CRPS treatment are an exact and early diagnosis as well as an active and multidisciplinary approach for maximal pain reduction and recovery for daily life; therefore appropriate treatment should be started as soon as possible [3].
[ "3", "4", "5" ]
245
44,106
1
false
The objects of CRPS treatment are an exact and early diagnosis as well as an active and multidisciplinary approach for maximal pain reduction and recovery for daily life; therefore appropriate treatment should be started as soon as possible.
[ "3" ]
The objects of CRPS treatment are an exact and early diagnosis as well as an active and multidisciplinary approach for maximal pain reduction and recovery for daily life; therefore appropriate treatment should be started as soon as possible.
true
true
true
true
true
7,629
1
DISCUSSION
1
3
[ "B3", "B4", "B5" ]
20,552,078
pmid-9647459|pmid-16772799|NA
In this case pain developed without nerve damage just following the excision and biopsy operation of chondroblastoma in the left humeral head.
[ "3", "4", "5" ]
142
44,107
0
false
In this case pain developed without nerve damage just following the excision and biopsy operation of chondroblastoma in the left humeral head.
[]
In this case pain developed without nerve damage just following the excision and biopsy operation of chondroblastoma in the left humeral head.
true
true
true
true
true
7,629
1
DISCUSSION
1
3
[ "B3", "B4", "B5" ]
20,552,078
pmid-9647459|pmid-16772799|NA
The patient was immediately referred to a pain clinic and given an early diagnosis, so that pain was managed through intensive pain control during hospitalization.
[ "3", "4", "5" ]
163
44,108
0
false
The patient was immediately referred to a pain clinic and given an early diagnosis, so that pain was managed through intensive pain control during hospitalization.
[]
The patient was immediately referred to a pain clinic and given an early diagnosis, so that pain was managed through intensive pain control during hospitalization.
true
true
true
true
true
7,629
1
DISCUSSION
1
3
[ "B3", "B4", "B5" ]
20,552,078
pmid-9647459|pmid-16772799|NA
However, after the patient's discharge, pain induced by some physical contact with others could not be reduced by any method that had previously been effective.
[ "3", "4", "5" ]
160
44,109
0
false
However, after the patient's discharge, pain induced by some physical contact with others could not be reduced by any method that had previously been effective.
[]
However, after the patient's discharge, pain induced by some physical contact with others could not be reduced by any method that had previously been effective.
true
true
true
true
true
7,629
1
DISCUSSION
1
3
[ "B3", "B4", "B5" ]
20,552,078
pmid-9647459|pmid-16772799|NA
It was six months since we began pain control in this patient.
[ "3", "4", "5" ]
62
44,110
0
false
It was six months since we began pain control in this patient.
[]
It was six months since we began pain control in this patient.
true
true
true
true
true
7,629
1
DISCUSSION
1
4
[ "B3", "B4", "B5" ]
20,552,078
pmid-9647459|pmid-16772799|NA
We considered spinal cord stimulator insertion [4], but he was still growing very quickly and we were afraid of migration of the electrode, so we tried TSB
[ "3", "4", "5" ]
155
44,111
1
false
We considered spinal cord stimulator insertion, but he was still growing very quickly and we were afraid of migration of the electrode, so we tried TSB
[ "4" ]
We considered spinal cord stimulator insertion, but he was still growing very quickly and we were afraid of migration of the electrode, so we tried TSB
true
true
false
true
false
7,629
2
DISCUSSION
1
6
[ "B6", "B7", "B8", "B9" ]
20,552,078
NA|pmid-8141469|pmid-2585696|NA
TSB is blockade of the spinal cord and brain by a large quantity of local anesthetics injected into the subarachnoid space.
[ "6", "7", "8", "9" ]
123
44,112
0
false
TSB is blockade of the spinal cord and brain by a large quantity of local anesthetics injected into the subarachnoid space.
[]
TSB is blockade of the spinal cord and brain by a large quantity of local anesthetics injected into the subarachnoid space.
true
true
true
true
true
7,630
2
DISCUSSION
1
6
[ "B6", "B7", "B8", "B9" ]
20,552,078
NA|pmid-8141469|pmid-2585696|NA
Its indications are CRPS, post herpetic neuralgia, phantom pain and so on.
[ "6", "7", "8", "9" ]
74
44,113
0
false
Its indications are CRPS, post herpetic neuralgia, phantom pain and so on.
[]
Its indications are CRPS, post herpetic neuralgia, phantom pain and so on.
true
true
true
true
true
7,630
2
DISCUSSION
1
6
[ "B6", "B7", "B8", "B9" ]
20,552,078
NA|pmid-8141469|pmid-2585696|NA
TSB has been performed over 1,300 times since it was first tried in 1972 at a Japanese hospital, but the numbers of cases are becoming reducing as other, various nerve blocks are being used [6].
[ "6", "7", "8", "9" ]
194
44,114
1
false
TSB has been performed over 1,300 times since it was first tried in 1972 at a Japanese hospital, but the numbers of cases are becoming reducing as other, various nerve blocks are being used.
[ "6" ]
TSB has been performed over 1,300 times since it was first tried in 1972 at a Japanese hospital, but the numbers of cases are becoming reducing as other, various nerve blocks are being used.
true
true
true
true
true
7,630
2
DISCUSSION
1
6
[ "B6", "B7", "B8", "B9" ]
20,552,078
NA|pmid-8141469|pmid-2585696|NA
Kimura et al.
[ "6", "7", "8", "9" ]
13
44,115
0
false
Kimura et al.
[]
Kimura et al.
true
true
true
true
true
7,630
2
DISCUSSION
1
7
[ "B6", "B7", "B8", "B9" ]
20,552,078
NA|pmid-8141469|pmid-2585696|NA
[7] and Goda et al.
[ "6", "7", "8", "9" ]
19
44,116
1
false
and Goda et al.
[ "7" ]
and Goda et al.
false
true
true
true
false
7,630
2
DISCUSSION
1
8
[ "B6", "B7", "B8", "B9" ]
20,552,078
NA|pmid-8141469|pmid-2585696|NA
[8] reported that TSB increases vagal nerve activity at the early stage of blockade, reduces sympathetic activity but relatively increases parasympathetic activity at the late stage of blockade on the power spectral analysis of the heart rate and peripheral blood flow variations.
[ "6", "7", "8", "9" ]
280
44,117
1
false
reported that TSB increases vagal nerve activity at the early stage of blockade, reduces sympathetic activity but relatively increases parasympathetic activity at the late stage of blockade on the power spectral analysis of the heart rate and peripheral blood flow variations.
[ "8" ]
reported that TSB increases vagal nerve activity at the early stage of blockade, reduces sympathetic activity but relatively increases parasympathetic activity at the late stage of blockade on the power spectral analysis of the heart rate and peripheral blood flow variations.
false
true
true
true
false
7,630
2
DISCUSSION
1
6
[ "B6", "B7", "B8", "B9" ]
20,552,078
NA|pmid-8141469|pmid-2585696|NA
Therefore, we expect that TSB may contribute to the recovery of balance between the sympathetic and parasympathetic nervous system and sympathetic chronic pain control.
[ "6", "7", "8", "9" ]
168
44,118
0
false
Therefore, we expect that TSB may contribute to the recovery of balance between the sympathetic and parasympathetic nervous system and sympathetic chronic pain control.
[]
Therefore, we expect that TSB may contribute to the recovery of balance between the sympathetic and parasympathetic nervous system and sympathetic chronic pain control.
true
true
true
true
true
7,630