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PMC2361998_fig5_21625.jpg | What does this image primarily show? | Fluorescence photomicrographs of 5 μm RIF-1 mouse tumour sections sampled at 5 min (A), 2 h (B) and 24 h (C) after i.v. injection of 5 mg kg−1 hypericin (red fluorescence) and 5 mg kg−1 DiOC18-labelled lipoproteins (green fluorescence). Overlay pictures show the combination of individual photomicrographs of hypericin i... |
PMC2361998_fig5_21619.jpg | What's the most prominent thing you notice in this picture? | Fluorescence photomicrographs of 5 μm RIF-1 mouse tumour sections sampled at 5 min (A), 2 h (B) and 24 h (C) after i.v. injection of 5 mg kg−1 hypericin (red fluorescence) and 5 mg kg−1 DiOC18-labelled lipoproteins (green fluorescence). Overlay pictures show the combination of individual photomicrographs of hypericin i... |
PMC2362000_fig2_21627.jpg | Can you identify the primary element in this image? | The protrusions on the surface of melanocytes correspond to actin-associated vesicles. The AFM topograph (A; height range: 4.3 μm) and corresponding phase-contrast image (B) of melanocytes treated with FITC-phalloidin show that some of the protrusions observed in the AFM topograph correspond to vesicles. Additionally, ... |
PMC2362000_fig2_21626.jpg | What key item or scene is captured in this photo? | The protrusions on the surface of melanocytes correspond to actin-associated vesicles. The AFM topograph (A; height range: 4.3 μm) and corresponding phase-contrast image (B) of melanocytes treated with FITC-phalloidin show that some of the protrusions observed in the AFM topograph correspond to vesicles. Additionally, ... |
PMC2362008_fig1_21630.jpg | What can you see in this picture? | AIDS-KS biopsies show immunoreactivity for IGF-IR. Serial sections of paraffin-embedded KS biopsies were evaluated for IGF-IR and CD34 expression. (A) Immunohistochemistry for IGF-IR showing reactivity in tumour SCs (small arrow) and some infiltrating leukocytes (long arrow). Original magnification × 250. The inset pan... |
PMC2362008_fig1_21631.jpg | What can you see in this picture? | AIDS-KS biopsies show immunoreactivity for IGF-IR. Serial sections of paraffin-embedded KS biopsies were evaluated for IGF-IR and CD34 expression. (A) Immunohistochemistry for IGF-IR showing reactivity in tumour SCs (small arrow) and some infiltrating leukocytes (long arrow). Original magnification × 250. The inset pan... |
PMC2362008_fig1_21632.jpg | What does this image primarily show? | AIDS-KS biopsies show immunoreactivity for IGF-IR. Serial sections of paraffin-embedded KS biopsies were evaluated for IGF-IR and CD34 expression. (A) Immunohistochemistry for IGF-IR showing reactivity in tumour SCs (small arrow) and some infiltrating leukocytes (long arrow). Original magnification × 250. The inset pan... |
PMC2362008_fig5_21635.jpg | What does this image primarily show? | Picropodophyllin, a specific inhibitor of IGF-IR activity, induces apoptosis in KSIMM cells. (A) KSIMM cells were treated with different concentrations of PPP for 48 h and subjected to MTT assay for the last 4 h. (B) KSIMM cells were treated, after starving for 24 h, with PPP (1 μg ml−1) or vehicle for 24 h and analyse... |
PMC2362009_fig2_21638.jpg | What is the main focus of this visual representation? | Immunohistochemistry: immunostaining was performed in cultures on chamber slides in quadruplicate. (A) Quiescent cells are negative for sst 2 positivity; (B) uniform immunopositivity for sst 2 in the proliferating cells; (C) quiescent cells are negative for sst 5 positivity; and (D) uniform immunopositivity for sst 5 i... |
PMC2362009_fig2_21640.jpg | What stands out most in this visual? | Immunohistochemistry: immunostaining was performed in cultures on chamber slides in quadruplicate. (A) Quiescent cells are negative for sst 2 positivity; (B) uniform immunopositivity for sst 2 in the proliferating cells; (C) quiescent cells are negative for sst 5 positivity; and (D) uniform immunopositivity for sst 5 i... |
PMC2362033_fig1_21642.jpg | What is being portrayed in this visual content? | Example of Ktrans maps, superimposed on T1-weighted images of a patient with primary peritoneal carcinoma with left pelvic side wall nodal metastases (arrow). Images are before and 4 h after the first dose of Combretastatin (52 mg m−2). The colour scale ranges from Ktrans values of 0 to 1 min−1. A dramatic reduction of... |
PMC2362033_fig1_21641.jpg | Describe the main subject of this image. | Example of Ktrans maps, superimposed on T1-weighted images of a patient with primary peritoneal carcinoma with left pelvic side wall nodal metastases (arrow). Images are before and 4 h after the first dose of Combretastatin (52 mg m−2). The colour scale ranges from Ktrans values of 0 to 1 min−1. A dramatic reduction of... |
PMC2362037_fig1_21644.jpg | What does this image primarily show? | Histological evaluation of Crohn's like reaction. HE-stained sections of MSI-H tumours with marked lymphocyte infiltration. (A) Exemplary illustration of Crohn's like lesions (black arrows) with apparent germinal centres surrounding the invasion front of the tumour (× 100 magnification). (B) Peritumoural lymphocytes su... |
PMC2362037_fig1_21643.jpg | What can you see in this picture? | Histological evaluation of Crohn's like reaction. HE-stained sections of MSI-H tumours with marked lymphocyte infiltration. (A) Exemplary illustration of Crohn's like lesions (black arrows) with apparent germinal centres surrounding the invasion front of the tumour (× 100 magnification). (B) Peritumoural lymphocytes su... |
PMC2362056_fig2_21653.jpg | What is the central feature of this picture? | Ductal carcinoma in situ specimens with representative immunohistochemical staining patterns for (upper row) bFGF (A), bFGF-R1 (B), VEGF-A (C), Flt-1 (D), KDR (E), and (lower row) VEGF-C (F), Flt-4 (G), ET-1 (H), ETAR (I), ETBR (J). |
PMC2362056_fig2_21648.jpg | What is the central feature of this picture? | Ductal carcinoma in situ specimens with representative immunohistochemical staining patterns for (upper row) bFGF (A), bFGF-R1 (B), VEGF-A (C), Flt-1 (D), KDR (E), and (lower row) VEGF-C (F), Flt-4 (G), ET-1 (H), ETAR (I), ETBR (J). |
PMC2362056_fig2_21650.jpg | Can you identify the primary element in this image? | Ductal carcinoma in situ specimens with representative immunohistochemical staining patterns for (upper row) bFGF (A), bFGF-R1 (B), VEGF-A (C), Flt-1 (D), KDR (E), and (lower row) VEGF-C (F), Flt-4 (G), ET-1 (H), ETAR (I), ETBR (J). |
PMC2362056_fig2_21647.jpg | Can you identify the primary element in this image? | Ductal carcinoma in situ specimens with representative immunohistochemical staining patterns for (upper row) bFGF (A), bFGF-R1 (B), VEGF-A (C), Flt-1 (D), KDR (E), and (lower row) VEGF-C (F), Flt-4 (G), ET-1 (H), ETAR (I), ETBR (J). |
PMC2362056_fig2_21649.jpg | What is the dominant medical problem in this image? | Ductal carcinoma in situ specimens with representative immunohistochemical staining patterns for (upper row) bFGF (A), bFGF-R1 (B), VEGF-A (C), Flt-1 (D), KDR (E), and (lower row) VEGF-C (F), Flt-4 (G), ET-1 (H), ETAR (I), ETBR (J). |
PMC2362056_fig2_21654.jpg | What stands out most in this visual? | Ductal carcinoma in situ specimens with representative immunohistochemical staining patterns for (upper row) bFGF (A), bFGF-R1 (B), VEGF-A (C), Flt-1 (D), KDR (E), and (lower row) VEGF-C (F), Flt-4 (G), ET-1 (H), ETAR (I), ETBR (J). |
PMC2362123_F1_21656.jpg | Describe the main subject of this image. | Differential expression of MMP-13 in breast cancer and peritumoral fibroblast cells. Invasive ductal carcinoma featured MMP-13 protein in the cytoplasm of both the cancer cells and peritumoral fibroblast cells (A). High levels of MMP-13 protein exclusively in the cytoplasm of the cancer cells (B). The brown color repre... |
PMC2362123_F1_21655.jpg | What is the core subject represented in this visual? | Differential expression of MMP-13 in breast cancer and peritumoral fibroblast cells. Invasive ductal carcinoma featured MMP-13 protein in the cytoplasm of both the cancer cells and peritumoral fibroblast cells (A). High levels of MMP-13 protein exclusively in the cytoplasm of the cancer cells (B). The brown color repre... |
PMC2362849_pone-0002115-g002_21662.jpg | What is the main focus of this visual representation? |
ck/MyoVIIA is necessary for JO organization during development.A: Comparison of control (ck13/CyO; white labels) vs. mutant (ck13/ck13; yellow labels) developing JO. Green channel: GFP-NompA labelling dendritic caps. Red channel: Texas red-phalloidin labelling actin filaments. Block arrows: developing scolopale rods. ... |
PMC2362849_pone-0002115-g002_21664.jpg | What's the most prominent thing you notice in this picture? |
ck/MyoVIIA is necessary for JO organization during development.A: Comparison of control (ck13/CyO; white labels) vs. mutant (ck13/ck13; yellow labels) developing JO. Green channel: GFP-NompA labelling dendritic caps. Red channel: Texas red-phalloidin labelling actin filaments. Block arrows: developing scolopale rods. ... |
PMC2362849_pone-0002115-g002_21660.jpg | What does this image primarily show? |
ck/MyoVIIA is necessary for JO organization during development.A: Comparison of control (ck13/CyO; white labels) vs. mutant (ck13/ck13; yellow labels) developing JO. Green channel: GFP-NompA labelling dendritic caps. Red channel: Texas red-phalloidin labelling actin filaments. Block arrows: developing scolopale rods. ... |
PMC2362849_pone-0002115-g002_21658.jpg | What object or scene is depicted here? |
ck/MyoVIIA is necessary for JO organization during development.A: Comparison of control (ck13/CyO; white labels) vs. mutant (ck13/ck13; yellow labels) developing JO. Green channel: GFP-NompA labelling dendritic caps. Red channel: Texas red-phalloidin labelling actin filaments. Block arrows: developing scolopale rods. ... |
PMC2362849_pone-0002115-g002_21663.jpg | Can you identify the primary element in this image? |
ck/MyoVIIA is necessary for JO organization during development.A: Comparison of control (ck13/CyO; white labels) vs. mutant (ck13/ck13; yellow labels) developing JO. Green channel: GFP-NompA labelling dendritic caps. Red channel: Texas red-phalloidin labelling actin filaments. Block arrows: developing scolopale rods. ... |
PMC2362849_pone-0002115-g002_21659.jpg | What object or scene is depicted here? |
ck/MyoVIIA is necessary for JO organization during development.A: Comparison of control (ck13/CyO; white labels) vs. mutant (ck13/ck13; yellow labels) developing JO. Green channel: GFP-NompA labelling dendritic caps. Red channel: Texas red-phalloidin labelling actin filaments. Block arrows: developing scolopale rods. ... |
PMC2362849_pone-0002115-g003_21667.jpg | What is shown in this image? | Scolopidia lacking ck/MyoVIIA are not attached to the a2/a3 joint during development.A: Wild type (ck13/CyO; white labels) and mutant (ck13/ck13; yellow labels) cultured antennal discs labelled as in Figure 2 support our finding that ck/MyoVIIA is necessary for JO organization. B: Representative EM micrographs from wil... |
PMC2362849_pone-0002115-g003_21666.jpg | What does this image primarily show? | Scolopidia lacking ck/MyoVIIA are not attached to the a2/a3 joint during development.A: Wild type (ck13/CyO; white labels) and mutant (ck13/ck13; yellow labels) cultured antennal discs labelled as in Figure 2 support our finding that ck/MyoVIIA is necessary for JO organization. B: Representative EM micrographs from wil... |
PMC2362849_pone-0002115-g003_21668.jpg | What is being portrayed in this visual content? | Scolopidia lacking ck/MyoVIIA are not attached to the a2/a3 joint during development.A: Wild type (ck13/CyO; white labels) and mutant (ck13/ck13; yellow labels) cultured antennal discs labelled as in Figure 2 support our finding that ck/MyoVIIA is necessary for JO organization. B: Representative EM micrographs from wil... |
PMC2362849_pone-0002115-g003_21669.jpg | What object or scene is depicted here? | Scolopidia lacking ck/MyoVIIA are not attached to the a2/a3 joint during development.A: Wild type (ck13/CyO; white labels) and mutant (ck13/ck13; yellow labels) cultured antennal discs labelled as in Figure 2 support our finding that ck/MyoVIIA is necessary for JO organization. B: Representative EM micrographs from wil... |
PMC2362849_pone-0002115-g003_21671.jpg | Can you identify the primary element in this image? | Scolopidia lacking ck/MyoVIIA are not attached to the a2/a3 joint during development.A: Wild type (ck13/CyO; white labels) and mutant (ck13/ck13; yellow labels) cultured antennal discs labelled as in Figure 2 support our finding that ck/MyoVIIA is necessary for JO organization. B: Representative EM micrographs from wil... |
PMC2363718_F3_21674.jpg | What is being portrayed in this visual content? | Fluoroscopic images illustrating the anatomic difference between the His bundle and the fast pathway. The left panel is the right anterior oblique (RAO) projection and the right panel is the left anterior oblique (LAO) projection. Note, in the LAO view, the quadrapolar ablation catheter points leftward when compared to... |
PMC2363720_F1B_21676.jpg | What is the central feature of this picture? | Follow-up roentgenogram in the same child shows normal lung growth at 20 months. Reprinted with permission from Agarwal R, et al Extrapleural intrathoracic implantation of permanent pacemaker in the pediatric age group. Ann Thorac Surg. 2007;83:1549-52. Elsevier © 2007, The Society of Thoracic Surgeons. |
PMC2363720_F2A_21677.jpg | What is the main focus of this visual representation? | Right ventricular angiography showing a left sided right atrium and ventricle in a girl operated for a large VSD and corrected transposition who was having hemodynamically unstable VT. |
PMC2363723_F2_21678.jpg | What is the main focus of this visual representation? | Intracardiac ultrasound image obtained of the left atrium showing a circumferential mapping catheter at the ostium of the left lower pulmonary vein. Accurate knowledge of the pulmonary vein ostium in children is critical and can be difficult to ascertain with standard fluoroscopy. |
PMC2363723_F8_21681.jpg | What is the core subject represented in this visual? | Intracardiac electrograms illustrating atrial pacing that advances the His bundle electrogram with a normal A-H interval. When there is simultaneous ventriculoatrial activation in an arrhythmia, AV node reentry and junctional tachycardia are both possible. However, when late coupled PACs easily advance the next His wit... |
PMC2363723_F8_21680.jpg | Describe the main subject of this image. | Intracardiac electrograms illustrating atrial pacing that advances the His bundle electrogram with a normal A-H interval. When there is simultaneous ventriculoatrial activation in an arrhythmia, AV node reentry and junctional tachycardia are both possible. However, when late coupled PACs easily advance the next His wit... |
PMC2363723_F10_21683.jpg | What key item or scene is captured in this photo? | Intracardiac electrograms obtained in a patient with a retrograde conducting left lateral accessory pathway. During ventricular pacing, 2:1 ventriculoatrial conduction is noted. The atrial activation sequence is eccentric. A fragmented electrogram (candidate potentials) is noted in the mid-coronary sinus leads. When ve... |
PMC2364153_fig1_21684.jpg | What is the dominant medical problem in this image? | Patient CP 4, Tc-99m hHMFG-1 radioimmunoscintigraphy. Positive left axillary nodes and breast cancer. |
PMC2364153_fig1_21685.jpg | What is the core subject represented in this visual? | Patient CP 4, Tc-99m hHMFG-1 radioimmunoscintigraphy. Positive left axillary nodes and breast cancer. |
PMC2364153_fig2_21686.jpg | What is being portrayed in this visual content? | Patient BC 1, Tc-99m hHMFG-1 radioimmunoscintigraphy. Positive right axillary nodes and breast cancer. |
PMC2364153_fig3_21687.jpg | Can you identify the primary element in this image? | Patient CT 5, Tc-99m hHMFG-1 radioimmunoscintigraphy. Negative left axilla nodes and positive breast cancer. |
PMC2364153_fig3_21688.jpg | What stands out most in this visual? | Patient CT 5, Tc-99m hHMFG-1 radioimmunoscintigraphy. Negative left axilla nodes and positive breast cancer. |
PMC2364153_fig4_21689.jpg | What is being portrayed in this visual content? | Patient W M 18, Tc-99m hHMFG-1 radioimmunoscintigraphy. Positive right axillary nodes and breast cancer. |
PMC2364153_fig4_21690.jpg | What is the focal point of this photograph? | Patient W M 18, Tc-99m hHMFG-1 radioimmunoscintigraphy. Positive right axillary nodes and breast cancer. |
PMC2364179_fig2_21693.jpg | What is the dominant medical problem in this image? | Serial sections of a prostatic bone marrow metastasis. Typical examples of the enzyme staining found from seven samples (see Table 2). Each photograph shows the same region of sample immunohistochemically (DAB) labelled for: (A) negative control (haematoxylin), (B) cytokeratin indicating the colonies of epithelial cell... |
PMC2364179_fig2_21694.jpg | What is the core subject represented in this visual? | Serial sections of a prostatic bone marrow metastasis. Typical examples of the enzyme staining found from seven samples (see Table 2). Each photograph shows the same region of sample immunohistochemically (DAB) labelled for: (A) negative control (haematoxylin), (B) cytokeratin indicating the colonies of epithelial cell... |
PMC2364187_fig4_21695.jpg | What is being portrayed in this visual content? | Bright field image of HCT116+ch3 (A) and HCT116+ch2 (B) after incubation with 0.1 μg ml−1 m-THPC for 24 h. After 24 h of incubation there was no detectable fluorescence within the nucleus. The nuclear membrane is distinctly stained in both cell lines. |
PMC2364240_fig4_21697.jpg | Can you identify the primary element in this image? | Binding of C28-sCE2 to the EpCAM expressing human colon cancer cell line SW1398. (A) FACS analysis of SW1398 cells that highly express EpCAM, with the supernatants of COS-7 cells transfected with psCE2 or pC28-sCE2. As a positive control the 323A3 antibody (bold line), directed to EpCAM was used. Binding was visualised... |
PMC2364240_fig4_21698.jpg | What is the main focus of this visual representation? | Binding of C28-sCE2 to the EpCAM expressing human colon cancer cell line SW1398. (A) FACS analysis of SW1398 cells that highly express EpCAM, with the supernatants of COS-7 cells transfected with psCE2 or pC28-sCE2. As a positive control the 323A3 antibody (bold line), directed to EpCAM was used. Binding was visualised... |
PMC2364253_fig3_21701.jpg | What is the focal point of this photograph? | Immunohistochemical staining patterns for GalNAc-T3. Normal bronchial epithelial cells (A) and bronchial gland cells (B) showed GalNAc-T3 expression. GalNAc-T3 expression was found diffusely in the cytoplasm of tumour cells or localised in the Golgi apparatus in an adenocarcinoma (C), but not seen in a squamous cell ca... |
PMC2364253_fig3_21703.jpg | What stands out most in this visual? | Immunohistochemical staining patterns for GalNAc-T3. Normal bronchial epithelial cells (A) and bronchial gland cells (B) showed GalNAc-T3 expression. GalNAc-T3 expression was found diffusely in the cytoplasm of tumour cells or localised in the Golgi apparatus in an adenocarcinoma (C), but not seen in a squamous cell ca... |
PMC2364645_pone-0002155-g005_21705.jpg | Describe the main subject of this image. | Induction phase of LTP is enhanced in CA3-lesioned animals after prolonged MPEP treatment.A. A transverse section through the rat brain at the level of ca. 3.1–3.3 mm posterior to bregma, demonstrating the lesioning of the hippocampal CA3 region as a result of kainate injection. B. Daily administration of MPEP for thre... |
PMC2364662_pone-0002175-g002_21709.jpg | Describe the main subject of this image. | MRI-guided focused ultrasound-microbubble treatment.Transgenic mice were sonicated at a single location determined from pre-treatment MR imaging and received intravenous MR-contrast agent and Trypan blue, an Aβ-targeting red fluorophore, after sonication. (A–B) T1-weighted, contrast-enhanced MR images taken 5 minutes f... |
PMC2364662_pone-0002175-g002_21714.jpg | Describe the main subject of this image. | MRI-guided focused ultrasound-microbubble treatment.Transgenic mice were sonicated at a single location determined from pre-treatment MR imaging and received intravenous MR-contrast agent and Trypan blue, an Aβ-targeting red fluorophore, after sonication. (A–B) T1-weighted, contrast-enhanced MR images taken 5 minutes f... |
PMC2364662_pone-0002175-g002_21713.jpg | What is the dominant medical problem in this image? | MRI-guided focused ultrasound-microbubble treatment.Transgenic mice were sonicated at a single location determined from pre-treatment MR imaging and received intravenous MR-contrast agent and Trypan blue, an Aβ-targeting red fluorophore, after sonication. (A–B) T1-weighted, contrast-enhanced MR images taken 5 minutes f... |
PMC2364662_pone-0002175-g002_21710.jpg | What's the most prominent thing you notice in this picture? | MRI-guided focused ultrasound-microbubble treatment.Transgenic mice were sonicated at a single location determined from pre-treatment MR imaging and received intravenous MR-contrast agent and Trypan blue, an Aβ-targeting red fluorophore, after sonication. (A–B) T1-weighted, contrast-enhanced MR images taken 5 minutes f... |
PMC2364662_pone-0002175-g002_21708.jpg | What stands out most in this visual? | MRI-guided focused ultrasound-microbubble treatment.Transgenic mice were sonicated at a single location determined from pre-treatment MR imaging and received intravenous MR-contrast agent and Trypan blue, an Aβ-targeting red fluorophore, after sonication. (A–B) T1-weighted, contrast-enhanced MR images taken 5 minutes f... |
PMC2364662_pone-0002175-g004_21720.jpg | What can you see in this picture? | Ultrasound enhanced delivery of anti-Aβ antibodies in a transgenic AD mouse.Alexa Fluor 350 conjugated goat anti-rabbit antibodies (blue fluorescence) were used to detect rabbit anti-Aβ antibodies injected immediately before FUS-MB. (A) The brain shows focal staining in the sonication location that overlaps with Trypan... |
PMC2364662_pone-0002175-g004_21719.jpg | What does this image primarily show? | Ultrasound enhanced delivery of anti-Aβ antibodies in a transgenic AD mouse.Alexa Fluor 350 conjugated goat anti-rabbit antibodies (blue fluorescence) were used to detect rabbit anti-Aβ antibodies injected immediately before FUS-MB. (A) The brain shows focal staining in the sonication location that overlaps with Trypan... |
PMC2364662_pone-0002175-g005_21716.jpg | What can you see in this picture? | Histological evaluation of FUS-MB treatment.Hemotoxylin and eosin stained tissue sections from the treated volume were examined for signs of tissue damage. We observed scattered petechial hemorrhages in treated regions (A), compared to no damage in untreated regions (B). (A) Treated hippocampus. Arrowheads indicate pet... |
PMC2364664_ppat-1000064-g001_21727.jpg | What's the most prominent thing you notice in this picture? | CagA is phosphorylated, associates with the cortex in Drosophila cells and disrupts eye development.(A) UAS-CagA was expressed in the Drosophila eye with GMR-GAL4. CagA protein (α-HA) was tyrosine phosphorylated (α-P-Tyr). Controls expressed only GMR-GAL4. (B) The CagA and CagAEPISA proteins were expressed in the eye t... |
PMC2364664_ppat-1000064-g001_21726.jpg | What stands out most in this visual? | CagA is phosphorylated, associates with the cortex in Drosophila cells and disrupts eye development.(A) UAS-CagA was expressed in the Drosophila eye with GMR-GAL4. CagA protein (α-HA) was tyrosine phosphorylated (α-P-Tyr). Controls expressed only GMR-GAL4. (B) The CagA and CagAEPISA proteins were expressed in the eye t... |
PMC2364664_ppat-1000064-g001_21730.jpg | What is shown in this image? | CagA is phosphorylated, associates with the cortex in Drosophila cells and disrupts eye development.(A) UAS-CagA was expressed in the Drosophila eye with GMR-GAL4. CagA protein (α-HA) was tyrosine phosphorylated (α-P-Tyr). Controls expressed only GMR-GAL4. (B) The CagA and CagAEPISA proteins were expressed in the eye t... |
PMC2364664_ppat-1000064-g001_21725.jpg | What key item or scene is captured in this photo? | CagA is phosphorylated, associates with the cortex in Drosophila cells and disrupts eye development.(A) UAS-CagA was expressed in the Drosophila eye with GMR-GAL4. CagA protein (α-HA) was tyrosine phosphorylated (α-P-Tyr). Controls expressed only GMR-GAL4. (B) The CagA and CagAEPISA proteins were expressed in the eye t... |
PMC2364664_ppat-1000064-g001_21734.jpg | What can you see in this picture? | CagA is phosphorylated, associates with the cortex in Drosophila cells and disrupts eye development.(A) UAS-CagA was expressed in the Drosophila eye with GMR-GAL4. CagA protein (α-HA) was tyrosine phosphorylated (α-P-Tyr). Controls expressed only GMR-GAL4. (B) The CagA and CagAEPISA proteins were expressed in the eye t... |
PMC2364664_ppat-1000064-g001_21731.jpg | What is the principal component of this image? | CagA is phosphorylated, associates with the cortex in Drosophila cells and disrupts eye development.(A) UAS-CagA was expressed in the Drosophila eye with GMR-GAL4. CagA protein (α-HA) was tyrosine phosphorylated (α-P-Tyr). Controls expressed only GMR-GAL4. (B) The CagA and CagAEPISA proteins were expressed in the eye t... |
PMC2364664_ppat-1000064-g001_21732.jpg | What is the principal component of this image? | CagA is phosphorylated, associates with the cortex in Drosophila cells and disrupts eye development.(A) UAS-CagA was expressed in the Drosophila eye with GMR-GAL4. CagA protein (α-HA) was tyrosine phosphorylated (α-P-Tyr). Controls expressed only GMR-GAL4. (B) The CagA and CagAEPISA proteins were expressed in the eye t... |
PMC2364664_ppat-1000064-g001_21733.jpg | What is the dominant medical problem in this image? | CagA is phosphorylated, associates with the cortex in Drosophila cells and disrupts eye development.(A) UAS-CagA was expressed in the Drosophila eye with GMR-GAL4. CagA protein (α-HA) was tyrosine phosphorylated (α-P-Tyr). Controls expressed only GMR-GAL4. (B) The CagA and CagAEPISA proteins were expressed in the eye t... |
PMC2364664_ppat-1000064-g001_21723.jpg | What's the most prominent thing you notice in this picture? | CagA is phosphorylated, associates with the cortex in Drosophila cells and disrupts eye development.(A) UAS-CagA was expressed in the Drosophila eye with GMR-GAL4. CagA protein (α-HA) was tyrosine phosphorylated (α-P-Tyr). Controls expressed only GMR-GAL4. (B) The CagA and CagAEPISA proteins were expressed in the eye t... |
PMC2364664_ppat-1000064-g001_21728.jpg | What is the focal point of this photograph? | CagA is phosphorylated, associates with the cortex in Drosophila cells and disrupts eye development.(A) UAS-CagA was expressed in the Drosophila eye with GMR-GAL4. CagA protein (α-HA) was tyrosine phosphorylated (α-P-Tyr). Controls expressed only GMR-GAL4. (B) The CagA and CagAEPISA proteins were expressed in the eye t... |
PMC2364748_fig4_21736.jpg | What stands out most in this visual? | Effect of NSAIDs on β-catenin localisation in SW480 human CRC cells. Indirect immunofluorescence for β-catenin was performed on adherent cells following 48 h treatment with each NSAID. Confocal microscopy was performed at the same magnification for all cell preparations (× 1000). (A) Cells incubated in the presence of ... |
PMC2364748_fig4_21735.jpg | What is the central feature of this picture? | Effect of NSAIDs on β-catenin localisation in SW480 human CRC cells. Indirect immunofluorescence for β-catenin was performed on adherent cells following 48 h treatment with each NSAID. Confocal microscopy was performed at the same magnification for all cell preparations (× 1000). (A) Cells incubated in the presence of ... |
PMC2364748_fig4_21737.jpg | What key item or scene is captured in this photo? | Effect of NSAIDs on β-catenin localisation in SW480 human CRC cells. Indirect immunofluorescence for β-catenin was performed on adherent cells following 48 h treatment with each NSAID. Confocal microscopy was performed at the same magnification for all cell preparations (× 1000). (A) Cells incubated in the presence of ... |
PMC2364748_fig4_21738.jpg | What is the focal point of this photograph? | Effect of NSAIDs on β-catenin localisation in SW480 human CRC cells. Indirect immunofluorescence for β-catenin was performed on adherent cells following 48 h treatment with each NSAID. Confocal microscopy was performed at the same magnification for all cell preparations (× 1000). (A) Cells incubated in the presence of ... |
PMC2364771_fig3_21743.jpg | What stands out most in this visual? | PPARγ protein expression in thyroid tissues assessed by immunohistochemistry. Positive cases presented diffuse nuclear immunostaining. (A) Negative poorly differentiated carcinoma; (B) papillary carcinoma of classic variant with faint immunostaining and corresponding peritumoral (C) and contralateral (D) normal tissue,... |
PMC2364771_fig3_21741.jpg | What is the central feature of this picture? | PPARγ protein expression in thyroid tissues assessed by immunohistochemistry. Positive cases presented diffuse nuclear immunostaining. (A) Negative poorly differentiated carcinoma; (B) papillary carcinoma of classic variant with faint immunostaining and corresponding peritumoral (C) and contralateral (D) normal tissue,... |
PMC2364771_fig3_21740.jpg | What is the main focus of this visual representation? | PPARγ protein expression in thyroid tissues assessed by immunohistochemistry. Positive cases presented diffuse nuclear immunostaining. (A) Negative poorly differentiated carcinoma; (B) papillary carcinoma of classic variant with faint immunostaining and corresponding peritumoral (C) and contralateral (D) normal tissue,... |
PMC2364790_fig1_21755.jpg | What does this image primarily show? | S100A6 immunostaining in benign, malignant, metastatic prostate and high-grade PIN samples. (A) Note the intense staining of the basal cells within the epithelium, seen as a single continuously stained cell layer (× 200 magnification). (B) Higher magnification shows intense staining in the cytoplasm and nuclei of basal... |
PMC2364790_fig1_21750.jpg | What is the main focus of this visual representation? | S100A6 immunostaining in benign, malignant, metastatic prostate and high-grade PIN samples. (A) Note the intense staining of the basal cells within the epithelium, seen as a single continuously stained cell layer (× 200 magnification). (B) Higher magnification shows intense staining in the cytoplasm and nuclei of basal... |
PMC2364790_fig1_21753.jpg | What object or scene is depicted here? | S100A6 immunostaining in benign, malignant, metastatic prostate and high-grade PIN samples. (A) Note the intense staining of the basal cells within the epithelium, seen as a single continuously stained cell layer (× 200 magnification). (B) Higher magnification shows intense staining in the cytoplasm and nuclei of basal... |
PMC2364790_fig1_21749.jpg | What can you see in this picture? | S100A6 immunostaining in benign, malignant, metastatic prostate and high-grade PIN samples. (A) Note the intense staining of the basal cells within the epithelium, seen as a single continuously stained cell layer (× 200 magnification). (B) Higher magnification shows intense staining in the cytoplasm and nuclei of basal... |
PMC2364790_fig1_21751.jpg | What object or scene is depicted here? | S100A6 immunostaining in benign, malignant, metastatic prostate and high-grade PIN samples. (A) Note the intense staining of the basal cells within the epithelium, seen as a single continuously stained cell layer (× 200 magnification). (B) Higher magnification shows intense staining in the cytoplasm and nuclei of basal... |
PMC2364790_fig1_21752.jpg | Describe the main subject of this image. | S100A6 immunostaining in benign, malignant, metastatic prostate and high-grade PIN samples. (A) Note the intense staining of the basal cells within the epithelium, seen as a single continuously stained cell layer (× 200 magnification). (B) Higher magnification shows intense staining in the cytoplasm and nuclei of basal... |
PMC2364790_fig1_21754.jpg | What is the core subject represented in this visual? | S100A6 immunostaining in benign, malignant, metastatic prostate and high-grade PIN samples. (A) Note the intense staining of the basal cells within the epithelium, seen as a single continuously stained cell layer (× 200 magnification). (B) Higher magnification shows intense staining in the cytoplasm and nuclei of basal... |
PMC2364790_fig2_21746.jpg | What is being portrayed in this visual content? | Comparison of S100A6 immunostaining with cytokeratin 5 and cytokeratin 18 immunostaining (× 100 magnification). (A) and (B) are serial sections of benign tissue stained with (A) cytokeratin 5 or (B) S100A6. Note that the staining patterns are similar with intense staining of the basal cell layer. In (B), note the weak-... |
PMC2364790_fig2_21745.jpg | What is the core subject represented in this visual? | Comparison of S100A6 immunostaining with cytokeratin 5 and cytokeratin 18 immunostaining (× 100 magnification). (A) and (B) are serial sections of benign tissue stained with (A) cytokeratin 5 or (B) S100A6. Note that the staining patterns are similar with intense staining of the basal cell layer. In (B), note the weak-... |
PMC2364790_fig2_21744.jpg | What can you see in this picture? | Comparison of S100A6 immunostaining with cytokeratin 5 and cytokeratin 18 immunostaining (× 100 magnification). (A) and (B) are serial sections of benign tissue stained with (A) cytokeratin 5 or (B) S100A6. Note that the staining patterns are similar with intense staining of the basal cell layer. In (B), note the weak-... |
PMC2364795_fig5_21758.jpg | What is the principal component of this image? | Immunohistochemical detection of WWOX protein in normal liver and HCC. Representative immunostaining results of WWOX protein expression. (A) Normal liver tissue sample. Note the strong WWOX cytoplasmic staining of hepatocytes contrasting with the negative staining of the stromal components (lower left corner). (B) HCC ... |
PMC2364795_fig5_21756.jpg | What is the core subject represented in this visual? | Immunohistochemical detection of WWOX protein in normal liver and HCC. Representative immunostaining results of WWOX protein expression. (A) Normal liver tissue sample. Note the strong WWOX cytoplasmic staining of hepatocytes contrasting with the negative staining of the stromal components (lower left corner). (B) HCC ... |
PMC2365560_pone-0002125-g002_21766.jpg | Can you identify the primary element in this image? | Conditional expression of MYC in the lung predisposes to bronchiogenic adenocarcinomas that are oncogene-independent.(A) MYC expression in the lung results in lung adenocarcinomas as shown (B) radiographically and (C & D) microscopically. MYC-induced tumors after 10 weeks of MYC-inactivation (removal of doxycycline) ar... |
PMC2365560_pone-0002125-g002_21768.jpg | What key item or scene is captured in this photo? | Conditional expression of MYC in the lung predisposes to bronchiogenic adenocarcinomas that are oncogene-independent.(A) MYC expression in the lung results in lung adenocarcinomas as shown (B) radiographically and (C & D) microscopically. MYC-induced tumors after 10 weeks of MYC-inactivation (removal of doxycycline) ar... |
PMC2365560_pone-0002125-g002_21763.jpg | What is the central feature of this picture? | Conditional expression of MYC in the lung predisposes to bronchiogenic adenocarcinomas that are oncogene-independent.(A) MYC expression in the lung results in lung adenocarcinomas as shown (B) radiographically and (C & D) microscopically. MYC-induced tumors after 10 weeks of MYC-inactivation (removal of doxycycline) ar... |
PMC2365560_pone-0002125-g002_21767.jpg | What is being portrayed in this visual content? | Conditional expression of MYC in the lung predisposes to bronchiogenic adenocarcinomas that are oncogene-independent.(A) MYC expression in the lung results in lung adenocarcinomas as shown (B) radiographically and (C & D) microscopically. MYC-induced tumors after 10 weeks of MYC-inactivation (removal of doxycycline) ar... |
PMC2365560_pone-0002125-g002_21770.jpg | What's the most prominent thing you notice in this picture? | Conditional expression of MYC in the lung predisposes to bronchiogenic adenocarcinomas that are oncogene-independent.(A) MYC expression in the lung results in lung adenocarcinomas as shown (B) radiographically and (C & D) microscopically. MYC-induced tumors after 10 weeks of MYC-inactivation (removal of doxycycline) ar... |
PMC2365560_pone-0002125-g002_21765.jpg | What is the main focus of this visual representation? | Conditional expression of MYC in the lung predisposes to bronchiogenic adenocarcinomas that are oncogene-independent.(A) MYC expression in the lung results in lung adenocarcinomas as shown (B) radiographically and (C & D) microscopically. MYC-induced tumors after 10 weeks of MYC-inactivation (removal of doxycycline) ar... |
PMC2365560_pone-0002125-g002_21762.jpg | What key item or scene is captured in this photo? | Conditional expression of MYC in the lung predisposes to bronchiogenic adenocarcinomas that are oncogene-independent.(A) MYC expression in the lung results in lung adenocarcinomas as shown (B) radiographically and (C & D) microscopically. MYC-induced tumors after 10 weeks of MYC-inactivation (removal of doxycycline) ar... |
PMC2365560_pone-0002125-g005_21775.jpg | What stands out most in this visual? | Regression of tumors following dual MYC/K-rasG12D-oncogene inactivation.(A) Representative serial µCT images of single and double-oncogene-induced lung tumors following withdrawal of doxycycline for 6 weeks. CR (CCSP-rtTA/TetO-K-rasG12D, n = 11) animals demonstrated rapid tumor regression within ∼2 weeks following inac... |
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