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PMC2408660_fig05_23492.jpg | What key item or scene is captured in this photo? | Dependence of lipid and GFP–MinD spiral formation on the presence of negatively charged lipids. A and B show FM 4-64 fluorescence signals for BFA2809 cells grown in the presence (A) or absence (B) of 100 μM IPTG. Images C and D are visualizations of GFP–MinD in IB1061 cells after gfp–minD induction with 0.1% xylose and... |
PMC2408707_fig1_23505.jpg | What is the principal component of this image? | CT scan showing a
contrast-enhanced lesion with central sunburst pattern and calcifications black
asterisk (upper (axial view), lower (sagittal view)) was noted in the para-nasal
and cheek soft-tissues. It extended medially into the surrounding nasal bone
structures and posteriorly into the left maxillary sinus and nas... |
PMC2408707_fig1_23506.jpg | What's the most prominent thing you notice in this picture? | CT scan showing a
contrast-enhanced lesion with central sunburst pattern and calcifications black
asterisk (upper (axial view), lower (sagittal view)) was noted in the para-nasal
and cheek soft-tissues. It extended medially into the surrounding nasal bone
structures and posteriorly into the left maxillary sinus and nas... |
PMC2408707_fig2_23504.jpg | What's the most prominent thing you notice in this picture? | (Histological examination) HES × 600
small-round-blue-cell arrow head tumor with highly cellular areas. Insert (gross
examination) showed a pseudoencapsulated fleshy tumor mass. |
PMC2408707_fig2_23503.jpg | What object or scene is depicted here? | (Histological examination) HES × 600
small-round-blue-cell arrow head tumor with highly cellular areas. Insert (gross
examination) showed a pseudoencapsulated fleshy tumor mass. |
PMC2408728_pone-0002369-g007_23512.jpg | What's the most prominent thing you notice in this picture? | Higher magnification of claudin-1 and ZO-1 immunostaining in vivo.Arrows in Panel ZO-1 show red staining of ZO-1 protein on the top of the intestinal crypts. Panel AvrA− showing disrupted ZO-1 and weaker claudin-1 staining in epithelial cells. ZO1 was detected at the tight junction of villous enterocytes in both normal... |
PMC2408728_pone-0002369-g007_23514.jpg | What key item or scene is captured in this photo? | Higher magnification of claudin-1 and ZO-1 immunostaining in vivo.Arrows in Panel ZO-1 show red staining of ZO-1 protein on the top of the intestinal crypts. Panel AvrA− showing disrupted ZO-1 and weaker claudin-1 staining in epithelial cells. ZO1 was detected at the tight junction of villous enterocytes in both normal... |
PMC2408728_pone-0002369-g007_23510.jpg | What is shown in this image? | Higher magnification of claudin-1 and ZO-1 immunostaining in vivo.Arrows in Panel ZO-1 show red staining of ZO-1 protein on the top of the intestinal crypts. Panel AvrA− showing disrupted ZO-1 and weaker claudin-1 staining in epithelial cells. ZO1 was detected at the tight junction of villous enterocytes in both normal... |
PMC2408728_pone-0002369-g007_23508.jpg | What is the core subject represented in this visual? | Higher magnification of claudin-1 and ZO-1 immunostaining in vivo.Arrows in Panel ZO-1 show red staining of ZO-1 protein on the top of the intestinal crypts. Panel AvrA− showing disrupted ZO-1 and weaker claudin-1 staining in epithelial cells. ZO1 was detected at the tight junction of villous enterocytes in both normal... |
PMC2408728_pone-0002369-g007_23513.jpg | Describe the main subject of this image. | Higher magnification of claudin-1 and ZO-1 immunostaining in vivo.Arrows in Panel ZO-1 show red staining of ZO-1 protein on the top of the intestinal crypts. Panel AvrA− showing disrupted ZO-1 and weaker claudin-1 staining in epithelial cells. ZO1 was detected at the tight junction of villous enterocytes in both normal... |
PMC2408728_pone-0002369-g007_23511.jpg | What is the core subject represented in this visual? | Higher magnification of claudin-1 and ZO-1 immunostaining in vivo.Arrows in Panel ZO-1 show red staining of ZO-1 protein on the top of the intestinal crypts. Panel AvrA− showing disrupted ZO-1 and weaker claudin-1 staining in epithelial cells. ZO1 was detected at the tight junction of villous enterocytes in both normal... |
PMC2408728_pone-0002369-g007_23515.jpg | What is the dominant medical problem in this image? | Higher magnification of claudin-1 and ZO-1 immunostaining in vivo.Arrows in Panel ZO-1 show red staining of ZO-1 protein on the top of the intestinal crypts. Panel AvrA− showing disrupted ZO-1 and weaker claudin-1 staining in epithelial cells. ZO1 was detected at the tight junction of villous enterocytes in both normal... |
PMC2408773_f4_23516.jpg | What is the focal point of this photograph? | Effect of the nitric oxide donor SNP on immunoreactivity for αSMA and fibronectin. Sparsely covered explants were cultured for nine days in the control medium (A-C) or in the control medium containing SNP (D-J). αSMA (B and E) and fibronectin (C and F) were then immunolocalized in fixed whole mounts of representative e... |
PMC2408773_f4_23517.jpg | What object or scene is depicted here? | Effect of the nitric oxide donor SNP on immunoreactivity for αSMA and fibronectin. Sparsely covered explants were cultured for nine days in the control medium (A-C) or in the control medium containing SNP (D-J). αSMA (B and E) and fibronectin (C and F) were then immunolocalized in fixed whole mounts of representative e... |
PMC2408773_f4_23519.jpg | What stands out most in this visual? | Effect of the nitric oxide donor SNP on immunoreactivity for αSMA and fibronectin. Sparsely covered explants were cultured for nine days in the control medium (A-C) or in the control medium containing SNP (D-J). αSMA (B and E) and fibronectin (C and F) were then immunolocalized in fixed whole mounts of representative e... |
PMC2408773_f4_23521.jpg | What can you see in this picture? | Effect of the nitric oxide donor SNP on immunoreactivity for αSMA and fibronectin. Sparsely covered explants were cultured for nine days in the control medium (A-C) or in the control medium containing SNP (D-J). αSMA (B and E) and fibronectin (C and F) were then immunolocalized in fixed whole mounts of representative e... |
PMC2408776_f1_23524.jpg | What is the main focus of this visual representation? | Immunohistochemical characterization of primary trabecular meshwork cell cultures. Immunohistochemical assays on the TM cells were positive for fibronectin (A), laminin (B), vimentin (C), neuronal specific enolase (D) and negative for the endothelial cell marker, factor VIII (E), which indicated that the primary cultur... |
PMC2408776_f1_23526.jpg | What is being portrayed in this visual content? | Immunohistochemical characterization of primary trabecular meshwork cell cultures. Immunohistochemical assays on the TM cells were positive for fibronectin (A), laminin (B), vimentin (C), neuronal specific enolase (D) and negative for the endothelial cell marker, factor VIII (E), which indicated that the primary cultur... |
PMC2408776_f1_23523.jpg | What is being portrayed in this visual content? | Immunohistochemical characterization of primary trabecular meshwork cell cultures. Immunohistochemical assays on the TM cells were positive for fibronectin (A), laminin (B), vimentin (C), neuronal specific enolase (D) and negative for the endothelial cell marker, factor VIII (E), which indicated that the primary cultur... |
PMC2408776_f1_23522.jpg | What is the main focus of this visual representation? | Immunohistochemical characterization of primary trabecular meshwork cell cultures. Immunohistochemical assays on the TM cells were positive for fibronectin (A), laminin (B), vimentin (C), neuronal specific enolase (D) and negative for the endothelial cell marker, factor VIII (E), which indicated that the primary cultur... |
PMC2408878_ppat-1000084-g004_23527.jpg | What does this image primarily show? | Validation of export of syntenic gene products.A) Syntenic gene products exported to the erythrocyte. Parasites expressing the gene indicated in each panel fused to gfp were stained with Hoechst 33342 and examined 18–36 hours after infection. Panels on the left-hand side show the overlap of the Hoechst 33342 staining a... |
PMC2408878_ppat-1000084-g004_23535.jpg | What is the focal point of this photograph? | Validation of export of syntenic gene products.A) Syntenic gene products exported to the erythrocyte. Parasites expressing the gene indicated in each panel fused to gfp were stained with Hoechst 33342 and examined 18–36 hours after infection. Panels on the left-hand side show the overlap of the Hoechst 33342 staining a... |
PMC2408878_ppat-1000084-g004_23536.jpg | What is the core subject represented in this visual? | Validation of export of syntenic gene products.A) Syntenic gene products exported to the erythrocyte. Parasites expressing the gene indicated in each panel fused to gfp were stained with Hoechst 33342 and examined 18–36 hours after infection. Panels on the left-hand side show the overlap of the Hoechst 33342 staining a... |
PMC2408878_ppat-1000084-g004_23529.jpg | Describe the main subject of this image. | Validation of export of syntenic gene products.A) Syntenic gene products exported to the erythrocyte. Parasites expressing the gene indicated in each panel fused to gfp were stained with Hoechst 33342 and examined 18–36 hours after infection. Panels on the left-hand side show the overlap of the Hoechst 33342 staining a... |
PMC2408878_ppat-1000084-g004_23534.jpg | What is the central feature of this picture? | Validation of export of syntenic gene products.A) Syntenic gene products exported to the erythrocyte. Parasites expressing the gene indicated in each panel fused to gfp were stained with Hoechst 33342 and examined 18–36 hours after infection. Panels on the left-hand side show the overlap of the Hoechst 33342 staining a... |
PMC2408878_ppat-1000084-g004_23540.jpg | What is the principal component of this image? | Validation of export of syntenic gene products.A) Syntenic gene products exported to the erythrocyte. Parasites expressing the gene indicated in each panel fused to gfp were stained with Hoechst 33342 and examined 18–36 hours after infection. Panels on the left-hand side show the overlap of the Hoechst 33342 staining a... |
PMC2408878_ppat-1000084-g004_23528.jpg | What is the principal component of this image? | Validation of export of syntenic gene products.A) Syntenic gene products exported to the erythrocyte. Parasites expressing the gene indicated in each panel fused to gfp were stained with Hoechst 33342 and examined 18–36 hours after infection. Panels on the left-hand side show the overlap of the Hoechst 33342 staining a... |
PMC2408878_ppat-1000084-g004_23538.jpg | What is shown in this image? | Validation of export of syntenic gene products.A) Syntenic gene products exported to the erythrocyte. Parasites expressing the gene indicated in each panel fused to gfp were stained with Hoechst 33342 and examined 18–36 hours after infection. Panels on the left-hand side show the overlap of the Hoechst 33342 staining a... |
PMC2408878_ppat-1000084-g004_23542.jpg | What key item or scene is captured in this photo? | Validation of export of syntenic gene products.A) Syntenic gene products exported to the erythrocyte. Parasites expressing the gene indicated in each panel fused to gfp were stained with Hoechst 33342 and examined 18–36 hours after infection. Panels on the left-hand side show the overlap of the Hoechst 33342 staining a... |
PMC2408878_ppat-1000084-g004_23533.jpg | Can you identify the primary element in this image? | Validation of export of syntenic gene products.A) Syntenic gene products exported to the erythrocyte. Parasites expressing the gene indicated in each panel fused to gfp were stained with Hoechst 33342 and examined 18–36 hours after infection. Panels on the left-hand side show the overlap of the Hoechst 33342 staining a... |
PMC2408878_ppat-1000084-g004_23539.jpg | Describe the main subject of this image. | Validation of export of syntenic gene products.A) Syntenic gene products exported to the erythrocyte. Parasites expressing the gene indicated in each panel fused to gfp were stained with Hoechst 33342 and examined 18–36 hours after infection. Panels on the left-hand side show the overlap of the Hoechst 33342 staining a... |
PMC2408893_fig4_23546.jpg | What is being portrayed in this visual content? | PpIX fluorescence in living cells. LNCaP cells were pretreated with vehicle (A,B) or with 10−7 M R1881 for 72 h (C). Microscopy. Transmission and fluorescence images of untreated LNCaP cells (A) and cells exposed to 0.3 mm ALA (B,C) without (B) or with (C) pretreatment with R1881. Flow cytometry. A large fraction of 0.... |
PMC2408893_fig4_23547.jpg | Describe the main subject of this image. | PpIX fluorescence in living cells. LNCaP cells were pretreated with vehicle (A,B) or with 10−7 M R1881 for 72 h (C). Microscopy. Transmission and fluorescence images of untreated LNCaP cells (A) and cells exposed to 0.3 mm ALA (B,C) without (B) or with (C) pretreatment with R1881. Flow cytometry. A large fraction of 0.... |
PMC2408922_F1_23549.jpg | What object or scene is depicted here? | Morphological examination of LSEC cultures over time by light microscopy. Freshly isolated LSECs cultures were established on 24 well plates and incubated either at hyperoxia (a-c) or at normoxia (d-f). The general morphology of the cultures was monitored by light microscopy at day 1 (a, d), day 3 (b, d) and day 5 (c, ... |
PMC2408924_F1_23551.jpg | Describe the main subject of this image. | Chest X ray (PA) view showing a large mediastinal mass occupying middle and lower zones of right chest and causing compressive atelectasis of middle lobe. |
PMC2408924_F2_23553.jpg | Describe the main subject of this image. | Chest X ray (right lateral view) confirms the anterior location of the mediastinal mass. |
PMC2408924_F3_23552.jpg | What is the focal point of this photograph? | CT scan of chest showing a smooth ovoid low density mass abutting the right anterior chest wall, diaphragm and the right atrium and ventricle. |
PMC2408964_pone-0002337-g002_23567.jpg | What can you see in this picture? | Localization of CYP3A43 mRNA in human brain by fluorescence in situ hybridization.(a) Intense fluorescence was seen in neuronal cell layers of frontal cortex. Differential localization was seen delineating the laminar architecture of the cortex. Bar = 100 µm (b) Higher magnification of cortical neurons (arrow). Bar = 2... |
PMC2408964_pone-0002337-g002_23566.jpg | What stands out most in this visual? | Localization of CYP3A43 mRNA in human brain by fluorescence in situ hybridization.(a) Intense fluorescence was seen in neuronal cell layers of frontal cortex. Differential localization was seen delineating the laminar architecture of the cortex. Bar = 100 µm (b) Higher magnification of cortical neurons (arrow). Bar = 2... |
PMC2408964_pone-0002337-g002_23555.jpg | What is the principal component of this image? | Localization of CYP3A43 mRNA in human brain by fluorescence in situ hybridization.(a) Intense fluorescence was seen in neuronal cell layers of frontal cortex. Differential localization was seen delineating the laminar architecture of the cortex. Bar = 100 µm (b) Higher magnification of cortical neurons (arrow). Bar = 2... |
PMC2408964_pone-0002337-g002_23554.jpg | What does this image primarily show? | Localization of CYP3A43 mRNA in human brain by fluorescence in situ hybridization.(a) Intense fluorescence was seen in neuronal cell layers of frontal cortex. Differential localization was seen delineating the laminar architecture of the cortex. Bar = 100 µm (b) Higher magnification of cortical neurons (arrow). Bar = 2... |
PMC2408964_pone-0002337-g002_23565.jpg | What is the focal point of this photograph? | Localization of CYP3A43 mRNA in human brain by fluorescence in situ hybridization.(a) Intense fluorescence was seen in neuronal cell layers of frontal cortex. Differential localization was seen delineating the laminar architecture of the cortex. Bar = 100 µm (b) Higher magnification of cortical neurons (arrow). Bar = 2... |
PMC2408964_pone-0002337-g002_23556.jpg | What is the core subject represented in this visual? | Localization of CYP3A43 mRNA in human brain by fluorescence in situ hybridization.(a) Intense fluorescence was seen in neuronal cell layers of frontal cortex. Differential localization was seen delineating the laminar architecture of the cortex. Bar = 100 µm (b) Higher magnification of cortical neurons (arrow). Bar = 2... |
PMC2408964_pone-0002337-g002_23557.jpg | What is the central feature of this picture? | Localization of CYP3A43 mRNA in human brain by fluorescence in situ hybridization.(a) Intense fluorescence was seen in neuronal cell layers of frontal cortex. Differential localization was seen delineating the laminar architecture of the cortex. Bar = 100 µm (b) Higher magnification of cortical neurons (arrow). Bar = 2... |
PMC2408964_pone-0002337-g002_23559.jpg | What can you see in this picture? | Localization of CYP3A43 mRNA in human brain by fluorescence in situ hybridization.(a) Intense fluorescence was seen in neuronal cell layers of frontal cortex. Differential localization was seen delineating the laminar architecture of the cortex. Bar = 100 µm (b) Higher magnification of cortical neurons (arrow). Bar = 2... |
PMC2408964_pone-0002337-g002_23560.jpg | What is the core subject represented in this visual? | Localization of CYP3A43 mRNA in human brain by fluorescence in situ hybridization.(a) Intense fluorescence was seen in neuronal cell layers of frontal cortex. Differential localization was seen delineating the laminar architecture of the cortex. Bar = 100 µm (b) Higher magnification of cortical neurons (arrow). Bar = 2... |
PMC2408964_pone-0002337-g002_23564.jpg | What key item or scene is captured in this photo? | Localization of CYP3A43 mRNA in human brain by fluorescence in situ hybridization.(a) Intense fluorescence was seen in neuronal cell layers of frontal cortex. Differential localization was seen delineating the laminar architecture of the cortex. Bar = 100 µm (b) Higher magnification of cortical neurons (arrow). Bar = 2... |
PMC2409078_pone-0002416-g003_23575.jpg | What does this image primarily show? | Increase in dynamin1 intensity at sites of clathrin-mediated endocytosis in PC12 cells.PC12 cells co-transfected with clathrin-dsRed (A) and dynamin1-EGFP (B) were imaged by live-cell TIR-FM. Frames with time-stamps represent magnifications of regions identified directly to the left. Quantification of the spot marker b... |
PMC2409078_pone-0002416-g003_23579.jpg | What is being portrayed in this visual content? | Increase in dynamin1 intensity at sites of clathrin-mediated endocytosis in PC12 cells.PC12 cells co-transfected with clathrin-dsRed (A) and dynamin1-EGFP (B) were imaged by live-cell TIR-FM. Frames with time-stamps represent magnifications of regions identified directly to the left. Quantification of the spot marker b... |
PMC2409078_pone-0002416-g003_23573.jpg | What is the focal point of this photograph? | Increase in dynamin1 intensity at sites of clathrin-mediated endocytosis in PC12 cells.PC12 cells co-transfected with clathrin-dsRed (A) and dynamin1-EGFP (B) were imaged by live-cell TIR-FM. Frames with time-stamps represent magnifications of regions identified directly to the left. Quantification of the spot marker b... |
PMC2409078_pone-0002416-g003_23569.jpg | What is the principal component of this image? | Increase in dynamin1 intensity at sites of clathrin-mediated endocytosis in PC12 cells.PC12 cells co-transfected with clathrin-dsRed (A) and dynamin1-EGFP (B) were imaged by live-cell TIR-FM. Frames with time-stamps represent magnifications of regions identified directly to the left. Quantification of the spot marker b... |
PMC2409078_pone-0002416-g003_23570.jpg | What is being portrayed in this visual content? | Increase in dynamin1 intensity at sites of clathrin-mediated endocytosis in PC12 cells.PC12 cells co-transfected with clathrin-dsRed (A) and dynamin1-EGFP (B) were imaged by live-cell TIR-FM. Frames with time-stamps represent magnifications of regions identified directly to the left. Quantification of the spot marker b... |
PMC2409078_pone-0002416-g003_23572.jpg | What's the most prominent thing you notice in this picture? | Increase in dynamin1 intensity at sites of clathrin-mediated endocytosis in PC12 cells.PC12 cells co-transfected with clathrin-dsRed (A) and dynamin1-EGFP (B) were imaged by live-cell TIR-FM. Frames with time-stamps represent magnifications of regions identified directly to the left. Quantification of the spot marker b... |
PMC2409078_pone-0002416-g003_23578.jpg | What is the focal point of this photograph? | Increase in dynamin1 intensity at sites of clathrin-mediated endocytosis in PC12 cells.PC12 cells co-transfected with clathrin-dsRed (A) and dynamin1-EGFP (B) were imaged by live-cell TIR-FM. Frames with time-stamps represent magnifications of regions identified directly to the left. Quantification of the spot marker b... |
PMC2409078_pone-0002416-g004_23581.jpg | What is the main focus of this visual representation? | Increase in dynamin2 intensity at sites of clathrin-mediated endocytosis in PC12 cells.PC12 cells co-transfected with clathrin-dsRed (A) and dynamin2-EGFP (B) were imaged by live-cell TIR-FM. Frames with time-stamps represent magnifications of regions identified directly to the left. Quantification of the spot marker b... |
PMC2409078_pone-0002416-g004_23587.jpg | What is the principal component of this image? | Increase in dynamin2 intensity at sites of clathrin-mediated endocytosis in PC12 cells.PC12 cells co-transfected with clathrin-dsRed (A) and dynamin2-EGFP (B) were imaged by live-cell TIR-FM. Frames with time-stamps represent magnifications of regions identified directly to the left. Quantification of the spot marker b... |
PMC2409170_fig1_23592.jpg | What is the main focus of this visual representation? | Immunohistochemical staining of LTA in TCRα−/− × AIM−/− mouse liver. (a) At a lower magnification, LTA immunoreactivity was prominent in the portal areas, but not in hepatic sinusoidal cells.(b) In the same sample, at ahigher magnification of the portal area, LTA immunoreactivity was observed in the cytoplasm of polymo... |
PMC2409170_fig1_23595.jpg | What key item or scene is captured in this photo? | Immunohistochemical staining of LTA in TCRα−/− × AIM−/− mouse liver. (a) At a lower magnification, LTA immunoreactivity was prominent in the portal areas, but not in hepatic sinusoidal cells.(b) In the same sample, at ahigher magnification of the portal area, LTA immunoreactivity was observed in the cytoplasm of polymo... |
PMC2409170_fig1_23597.jpg | What key item or scene is captured in this photo? | Immunohistochemical staining of LTA in TCRα−/− × AIM−/− mouse liver. (a) At a lower magnification, LTA immunoreactivity was prominent in the portal areas, but not in hepatic sinusoidal cells.(b) In the same sample, at ahigher magnification of the portal area, LTA immunoreactivity was observed in the cytoplasm of polymo... |
PMC2409170_fig1_23593.jpg | What is shown in this image? | Immunohistochemical staining of LTA in TCRα−/− × AIM−/− mouse liver. (a) At a lower magnification, LTA immunoreactivity was prominent in the portal areas, but not in hepatic sinusoidal cells.(b) In the same sample, at ahigher magnification of the portal area, LTA immunoreactivity was observed in the cytoplasm of polymo... |
PMC2409170_fig1_23591.jpg | What stands out most in this visual? | Immunohistochemical staining of LTA in TCRα−/− × AIM−/− mouse liver. (a) At a lower magnification, LTA immunoreactivity was prominent in the portal areas, but not in hepatic sinusoidal cells.(b) In the same sample, at ahigher magnification of the portal area, LTA immunoreactivity was observed in the cytoplasm of polymo... |
PMC2409170_fig1_23596.jpg | What is being portrayed in this visual content? | Immunohistochemical staining of LTA in TCRα−/− × AIM−/− mouse liver. (a) At a lower magnification, LTA immunoreactivity was prominent in the portal areas, but not in hepatic sinusoidal cells.(b) In the same sample, at ahigher magnification of the portal area, LTA immunoreactivity was observed in the cytoplasm of polymo... |
PMC2409170_fig2_23611.jpg | What is the focal point of this photograph? | Pathological findings and immunohistochemical staining of LTA in the gastrointestinal tract of TCRα−/− × AIM−/− mice. (a) In the stomach, mild polymorphic inflammatory cellular infiltrates were observed in both mucosal and submucosal layers in all of the TCRα−/− × AIM−/− mice. LTA immunoreactivity was detectable in the... |
PMC2409170_fig2_23613.jpg | What object or scene is depicted here? | Pathological findings and immunohistochemical staining of LTA in the gastrointestinal tract of TCRα−/− × AIM−/− mice. (a) In the stomach, mild polymorphic inflammatory cellular infiltrates were observed in both mucosal and submucosal layers in all of the TCRα−/− × AIM−/− mice. LTA immunoreactivity was detectable in the... |
PMC2409170_fig2_23609.jpg | What can you see in this picture? | Pathological findings and immunohistochemical staining of LTA in the gastrointestinal tract of TCRα−/− × AIM−/− mice. (a) In the stomach, mild polymorphic inflammatory cellular infiltrates were observed in both mucosal and submucosal layers in all of the TCRα−/− × AIM−/− mice. LTA immunoreactivity was detectable in the... |
PMC2409170_fig2_23610.jpg | What is the dominant medical problem in this image? | Pathological findings and immunohistochemical staining of LTA in the gastrointestinal tract of TCRα−/− × AIM−/− mice. (a) In the stomach, mild polymorphic inflammatory cellular infiltrates were observed in both mucosal and submucosal layers in all of the TCRα−/− × AIM−/− mice. LTA immunoreactivity was detectable in the... |
PMC2409170_fig2_23614.jpg | What object or scene is depicted here? | Pathological findings and immunohistochemical staining of LTA in the gastrointestinal tract of TCRα−/− × AIM−/− mice. (a) In the stomach, mild polymorphic inflammatory cellular infiltrates were observed in both mucosal and submucosal layers in all of the TCRα−/− × AIM−/− mice. LTA immunoreactivity was detectable in the... |
PMC2409170_fig3_23599.jpg | What object or scene is depicted here? | Pathological findings and immunohistochemical staining of LTA in the pancreas, kidney and spleen. (a) In the pancreas, marked inflammatory cellular infiltrates around pancreatic ducts were observed (H&E, lower middle column). LTA was located in the cytoplasm of polymorphic inflammatory cells and in the stromal connecti... |
PMC2409170_fig3_23602.jpg | What stands out most in this visual? | Pathological findings and immunohistochemical staining of LTA in the pancreas, kidney and spleen. (a) In the pancreas, marked inflammatory cellular infiltrates around pancreatic ducts were observed (H&E, lower middle column). LTA was located in the cytoplasm of polymorphic inflammatory cells and in the stromal connecti... |
PMC2409170_fig3_23603.jpg | What key item or scene is captured in this photo? | Pathological findings and immunohistochemical staining of LTA in the pancreas, kidney and spleen. (a) In the pancreas, marked inflammatory cellular infiltrates around pancreatic ducts were observed (H&E, lower middle column). LTA was located in the cytoplasm of polymorphic inflammatory cells and in the stromal connecti... |
PMC2409170_fig3_23598.jpg | What does this image primarily show? | Pathological findings and immunohistochemical staining of LTA in the pancreas, kidney and spleen. (a) In the pancreas, marked inflammatory cellular infiltrates around pancreatic ducts were observed (H&E, lower middle column). LTA was located in the cytoplasm of polymorphic inflammatory cells and in the stromal connecti... |
PMC2409170_fig3_23600.jpg | What is the main focus of this visual representation? | Pathological findings and immunohistochemical staining of LTA in the pancreas, kidney and spleen. (a) In the pancreas, marked inflammatory cellular infiltrates around pancreatic ducts were observed (H&E, lower middle column). LTA was located in the cytoplasm of polymorphic inflammatory cells and in the stromal connecti... |
PMC2409172_fig4_23605.jpg | What is the main focus of this visual representation? | Histopathological appearances in bone marrow trephine biopsy from a patient with primary CAD. Lymphoid infiltrates may be of variable size; large (A), medium-sized (B), or often small and poorly outlined (C) which renders them barely detectable within areas of hyperplastic erythropoiesis unless immunohistological stain... |
PMC2409172_fig4_23607.jpg | Can you identify the primary element in this image? | Histopathological appearances in bone marrow trephine biopsy from a patient with primary CAD. Lymphoid infiltrates may be of variable size; large (A), medium-sized (B), or often small and poorly outlined (C) which renders them barely detectable within areas of hyperplastic erythropoiesis unless immunohistological stain... |
PMC2409172_fig4_23606.jpg | What is the main focus of this visual representation? | Histopathological appearances in bone marrow trephine biopsy from a patient with primary CAD. Lymphoid infiltrates may be of variable size; large (A), medium-sized (B), or often small and poorly outlined (C) which renders them barely detectable within areas of hyperplastic erythropoiesis unless immunohistological stain... |
PMC2409183_fig3_23621.jpg | What is the main focus of this visual representation? | The E218Q mutant of basigin, but not the E218R mutant, is correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This Figure is reproduced in colou... |
PMC2409183_fig3_23623.jpg | What is the dominant medical problem in this image? | The E218Q mutant of basigin, but not the E218R mutant, is correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This Figure is reproduced in colou... |
PMC2409183_fig3_23617.jpg | What can you see in this picture? | The E218Q mutant of basigin, but not the E218R mutant, is correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This Figure is reproduced in colou... |
PMC2409183_fig3_23619.jpg | What can you see in this picture? | The E218Q mutant of basigin, but not the E218R mutant, is correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This Figure is reproduced in colou... |
PMC2409183_fig3_23616.jpg | What is the main focus of this visual representation? | The E218Q mutant of basigin, but not the E218R mutant, is correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This Figure is reproduced in colou... |
PMC2409183_fig3_23624.jpg | What is the central feature of this picture? | The E218Q mutant of basigin, but not the E218R mutant, is correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This Figure is reproduced in colou... |
PMC2409183_fig3_23618.jpg | What is the core subject represented in this visual? | The E218Q mutant of basigin, but not the E218R mutant, is correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This Figure is reproduced in colou... |
PMC2409183_fig3_23615.jpg | What does this image primarily show? | The E218Q mutant of basigin, but not the E218R mutant, is correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This Figure is reproduced in colou... |
PMC2409183_fig5_23628.jpg | What is the core subject represented in this visual? | D302R/R306E-MCT1 is expressed at the plasma membrane of Xenopus oocytes but is inactive. Details are as given for Figure 4. Transport measurements are not shown because D302R/R306E-MCT1 failed to elicit any lactate transport whether or not WT- or E218R-basigin cRNA was co-injected. This Figure is reproduced in colour i... |
PMC2409183_fig5_23625.jpg | What's the most prominent thing you notice in this picture? | D302R/R306E-MCT1 is expressed at the plasma membrane of Xenopus oocytes but is inactive. Details are as given for Figure 4. Transport measurements are not shown because D302R/R306E-MCT1 failed to elicit any lactate transport whether or not WT- or E218R-basigin cRNA was co-injected. This Figure is reproduced in colour i... |
PMC2409183_fig5_23627.jpg | What key item or scene is captured in this photo? | D302R/R306E-MCT1 is expressed at the plasma membrane of Xenopus oocytes but is inactive. Details are as given for Figure 4. Transport measurements are not shown because D302R/R306E-MCT1 failed to elicit any lactate transport whether or not WT- or E218R-basigin cRNA was co-injected. This Figure is reproduced in colour i... |
PMC2409183_fig5_23630.jpg | What is the dominant medical problem in this image? | D302R/R306E-MCT1 is expressed at the plasma membrane of Xenopus oocytes but is inactive. Details are as given for Figure 4. Transport measurements are not shown because D302R/R306E-MCT1 failed to elicit any lactate transport whether or not WT- or E218R-basigin cRNA was co-injected. This Figure is reproduced in colour i... |
PMC2409183_fig6_23635.jpg | What is the core subject represented in this visual? | R306K-MCT1 is expressed at the plasma membrane of Xenopus oocytes but is inactive. Details are as given for Figure 4. Transport measurements are not shown because R306K-MCT1 failed to elicit any lactate transport whether or not WT- or E218R-basigin cRNA was co-injected. This Figure is reproduced in colour in Molecular ... |
PMC2409183_fig6_23632.jpg | What can you see in this picture? | R306K-MCT1 is expressed at the plasma membrane of Xenopus oocytes but is inactive. Details are as given for Figure 4. Transport measurements are not shown because R306K-MCT1 failed to elicit any lactate transport whether or not WT- or E218R-basigin cRNA was co-injected. This Figure is reproduced in colour in Molecular ... |
PMC2409183_fig6_23634.jpg | What's the most prominent thing you notice in this picture? | R306K-MCT1 is expressed at the plasma membrane of Xenopus oocytes but is inactive. Details are as given for Figure 4. Transport measurements are not shown because R306K-MCT1 failed to elicit any lactate transport whether or not WT- or E218R-basigin cRNA was co-injected. This Figure is reproduced in colour in Molecular ... |
PMC2409183_fig6_23633.jpg | What is the main focus of this visual representation? | R306K-MCT1 is expressed at the plasma membrane of Xenopus oocytes but is inactive. Details are as given for Figure 4. Transport measurements are not shown because R306K-MCT1 failed to elicit any lactate transport whether or not WT- or E218R-basigin cRNA was co-injected. This Figure is reproduced in colour in Molecular ... |
PMC2409183_fig7_23649.jpg | What is the focal point of this photograph? | Mutation of Arg86 or Arg196 to glutamine or glutamate does not prevent MCT1 from being correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This ... |
PMC2409183_fig7_23651.jpg | What does this image primarily show? | Mutation of Arg86 or Arg196 to glutamine or glutamate does not prevent MCT1 from being correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This ... |
PMC2409183_fig7_23642.jpg | What's the most prominent thing you notice in this picture? | Mutation of Arg86 or Arg196 to glutamine or glutamate does not prevent MCT1 from being correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This ... |
PMC2409183_fig7_23650.jpg | What can you see in this picture? | Mutation of Arg86 or Arg196 to glutamine or glutamate does not prevent MCT1 from being correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This ... |
PMC2409183_fig7_23644.jpg | What is the central feature of this picture? | Mutation of Arg86 or Arg196 to glutamine or glutamate does not prevent MCT1 from being correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This ... |
PMC2409183_fig7_23638.jpg | What is the central feature of this picture? | Mutation of Arg86 or Arg196 to glutamine or glutamate does not prevent MCT1 from being correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This ... |
PMC2409183_fig7_23640.jpg | What is the principal component of this image? | Mutation of Arg86 or Arg196 to glutamine or glutamate does not prevent MCT1 from being correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This ... |
PMC2409183_fig7_23637.jpg | What is shown in this image? | Mutation of Arg86 or Arg196 to glutamine or glutamate does not prevent MCT1 from being correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This ... |
PMC2409183_fig7_23636.jpg | What is the dominant medical problem in this image? | Mutation of Arg86 or Arg196 to glutamine or glutamate does not prevent MCT1 from being correctly targeted to the plasma membrane of COS cells. COS cells were co-transfected with MCT1-c-CFP and basigin-c-YFP constructs containing the mutations indicated and live cell imaging performed as described under ‘Methods’. This ... |
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