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PMC1257439_F5_3444.jpg | What is the central feature of this picture? | Double immunofluorescence labelling of normal and dcSSc skin biopsies. Cryosections from (a,c) normal and (b,d) dcSSc were double stained for endothelial cells using (a,b) PAL-E antibody and Thy-1 and (c,d) α-SMA and Thy-1. Thy-1 is labelled with FITC while PAL-E and α-SMA are labelled with Texas Red. In both (a) normal and (b) dcSSc, immunofluorescence for Thy-1 ((a,b) arrow, green colour) and PAL-E ((a,b) arrowhead, red colour) was consistently exclusive and showed no colocalization. In both (c) normal and (d) dcSSc, strong colocalization between Thy-1 and α-SMA was evident ((c,d) arrows, yellow colour). In normal skin, Thy-1 immunofluorescence that did not colocalize with α-SMA was observed immediately adjacent to microvessels ((c) arrowheads, green colour). Cryosections from dcSSc were double stained for (e,f,g) ED-A FN and α-SMA and (h) ED-A FN and Thy-1. ED-A FN is labelled with Texas Red while α-SMA and Thy-1 are labelled with FITC. Cell nuclei are counterstained blue with DAPI. Colocalization between α-SMA and ED-A FN was detected in dermal fibroblastic cells ((e) arrows, yellow colour) as well as in the microvascular wall ((f,g) arrows, yellow colour). Colocalization was also observed between ED-A FN and Thy-1 in both the microvascular wall ((h) arrow, yellow colour) and in dermal fibroblastic cells ((h) arrowheads, yellow colour). Original magnification (a-d,h) × 10, (e,f) × 20, (g) × 40. α-SMA, alpha smooth muscle actin; DAPI, 4,6-diamidino-2-phenylindole; dcSSc, diffuse cutaneous systemic sclerosis; ED-A FN, ED-A splice variant of fibronectin; FITC, fluorescein isothiocyanate. |
PMC1257439_F5_3439.jpg | What is being portrayed in this visual content? | Double immunofluorescence labelling of normal and dcSSc skin biopsies. Cryosections from (a,c) normal and (b,d) dcSSc were double stained for endothelial cells using (a,b) PAL-E antibody and Thy-1 and (c,d) α-SMA and Thy-1. Thy-1 is labelled with FITC while PAL-E and α-SMA are labelled with Texas Red. In both (a) normal and (b) dcSSc, immunofluorescence for Thy-1 ((a,b) arrow, green colour) and PAL-E ((a,b) arrowhead, red colour) was consistently exclusive and showed no colocalization. In both (c) normal and (d) dcSSc, strong colocalization between Thy-1 and α-SMA was evident ((c,d) arrows, yellow colour). In normal skin, Thy-1 immunofluorescence that did not colocalize with α-SMA was observed immediately adjacent to microvessels ((c) arrowheads, green colour). Cryosections from dcSSc were double stained for (e,f,g) ED-A FN and α-SMA and (h) ED-A FN and Thy-1. ED-A FN is labelled with Texas Red while α-SMA and Thy-1 are labelled with FITC. Cell nuclei are counterstained blue with DAPI. Colocalization between α-SMA and ED-A FN was detected in dermal fibroblastic cells ((e) arrows, yellow colour) as well as in the microvascular wall ((f,g) arrows, yellow colour). Colocalization was also observed between ED-A FN and Thy-1 in both the microvascular wall ((h) arrow, yellow colour) and in dermal fibroblastic cells ((h) arrowheads, yellow colour). Original magnification (a-d,h) × 10, (e,f) × 20, (g) × 40. α-SMA, alpha smooth muscle actin; DAPI, 4,6-diamidino-2-phenylindole; dcSSc, diffuse cutaneous systemic sclerosis; ED-A FN, ED-A splice variant of fibronectin; FITC, fluorescein isothiocyanate. |
PMC1257439_F5_3443.jpg | What is the central feature of this picture? | Double immunofluorescence labelling of normal and dcSSc skin biopsies. Cryosections from (a,c) normal and (b,d) dcSSc were double stained for endothelial cells using (a,b) PAL-E antibody and Thy-1 and (c,d) α-SMA and Thy-1. Thy-1 is labelled with FITC while PAL-E and α-SMA are labelled with Texas Red. In both (a) normal and (b) dcSSc, immunofluorescence for Thy-1 ((a,b) arrow, green colour) and PAL-E ((a,b) arrowhead, red colour) was consistently exclusive and showed no colocalization. In both (c) normal and (d) dcSSc, strong colocalization between Thy-1 and α-SMA was evident ((c,d) arrows, yellow colour). In normal skin, Thy-1 immunofluorescence that did not colocalize with α-SMA was observed immediately adjacent to microvessels ((c) arrowheads, green colour). Cryosections from dcSSc were double stained for (e,f,g) ED-A FN and α-SMA and (h) ED-A FN and Thy-1. ED-A FN is labelled with Texas Red while α-SMA and Thy-1 are labelled with FITC. Cell nuclei are counterstained blue with DAPI. Colocalization between α-SMA and ED-A FN was detected in dermal fibroblastic cells ((e) arrows, yellow colour) as well as in the microvascular wall ((f,g) arrows, yellow colour). Colocalization was also observed between ED-A FN and Thy-1 in both the microvascular wall ((h) arrow, yellow colour) and in dermal fibroblastic cells ((h) arrowheads, yellow colour). Original magnification (a-d,h) × 10, (e,f) × 20, (g) × 40. α-SMA, alpha smooth muscle actin; DAPI, 4,6-diamidino-2-phenylindole; dcSSc, diffuse cutaneous systemic sclerosis; ED-A FN, ED-A splice variant of fibronectin; FITC, fluorescein isothiocyanate. |
PMC1257439_F7_3436.jpg | What's the most prominent thing you notice in this picture? | Nailfold capillaroscopy of (a) normal and (b,c) dcSSc patients. In the active pattern of capillary damage, frequent giant capillaries are present ((b) arrow) accompanied by moderate capillary loss and disorganisation of capillary architecture. Late disease pattern was characterized by severe capillary disorganisation with loss of capillaries ((c) arrow). Magnification ×150. dcSSc, diffuse cutaneous systemic sclerosis. |
PMC1257598_f3-ehp0113-000729_3448.jpg | What is shown in this image? | Histopathologic examination of leg tumor surrounding WA pellet. (A) H&E-stained section of leg tumor from F344 rat showing WA pellet hole (P); bar = 500 μm. (B) H&E-stained tumor section showing neoplastic infiltration of preexisting muscle fibers (MF); bar = 200 μm. (C) H&E-stained tumor section showing neoplastic cells with numerous mitoses (arrows) and bizarre mitotic figures (BZ); bar = 100 μm. (D) H&E-stained tumor section showing pleomorphic cell (arrow); bar = 100 μm. (E) Desmin staining of leg tumor showing neoplastic cells (NC) and muscle fibers (MF); bar = 500 μm. (F) Desmin staining of neoplastic cells; bar = 50 μm. |
PMC1257598_f3-ehp0113-000729_3449.jpg | Can you identify the primary element in this image? | Histopathologic examination of leg tumor surrounding WA pellet. (A) H&E-stained section of leg tumor from F344 rat showing WA pellet hole (P); bar = 500 μm. (B) H&E-stained tumor section showing neoplastic infiltration of preexisting muscle fibers (MF); bar = 200 μm. (C) H&E-stained tumor section showing neoplastic cells with numerous mitoses (arrows) and bizarre mitotic figures (BZ); bar = 100 μm. (D) H&E-stained tumor section showing pleomorphic cell (arrow); bar = 100 μm. (E) Desmin staining of leg tumor showing neoplastic cells (NC) and muscle fibers (MF); bar = 500 μm. (F) Desmin staining of neoplastic cells; bar = 50 μm. |
PMC1257598_f3-ehp0113-000729_3446.jpg | Describe the main subject of this image. | Histopathologic examination of leg tumor surrounding WA pellet. (A) H&E-stained section of leg tumor from F344 rat showing WA pellet hole (P); bar = 500 μm. (B) H&E-stained tumor section showing neoplastic infiltration of preexisting muscle fibers (MF); bar = 200 μm. (C) H&E-stained tumor section showing neoplastic cells with numerous mitoses (arrows) and bizarre mitotic figures (BZ); bar = 100 μm. (D) H&E-stained tumor section showing pleomorphic cell (arrow); bar = 100 μm. (E) Desmin staining of leg tumor showing neoplastic cells (NC) and muscle fibers (MF); bar = 500 μm. (F) Desmin staining of neoplastic cells; bar = 50 μm. |
PMC1257598_f3-ehp0113-000729_3451.jpg | What object or scene is depicted here? | Histopathologic examination of leg tumor surrounding WA pellet. (A) H&E-stained section of leg tumor from F344 rat showing WA pellet hole (P); bar = 500 μm. (B) H&E-stained tumor section showing neoplastic infiltration of preexisting muscle fibers (MF); bar = 200 μm. (C) H&E-stained tumor section showing neoplastic cells with numerous mitoses (arrows) and bizarre mitotic figures (BZ); bar = 100 μm. (D) H&E-stained tumor section showing pleomorphic cell (arrow); bar = 100 μm. (E) Desmin staining of leg tumor showing neoplastic cells (NC) and muscle fibers (MF); bar = 500 μm. (F) Desmin staining of neoplastic cells; bar = 50 μm. |
PMC1257598_f3-ehp0113-000729_3450.jpg | What does this image primarily show? | Histopathologic examination of leg tumor surrounding WA pellet. (A) H&E-stained section of leg tumor from F344 rat showing WA pellet hole (P); bar = 500 μm. (B) H&E-stained tumor section showing neoplastic infiltration of preexisting muscle fibers (MF); bar = 200 μm. (C) H&E-stained tumor section showing neoplastic cells with numerous mitoses (arrows) and bizarre mitotic figures (BZ); bar = 100 μm. (D) H&E-stained tumor section showing pleomorphic cell (arrow); bar = 100 μm. (E) Desmin staining of leg tumor showing neoplastic cells (NC) and muscle fibers (MF); bar = 500 μm. (F) Desmin staining of neoplastic cells; bar = 50 μm. |
PMC1257598_f3-ehp0113-000729_3447.jpg | What stands out most in this visual? | Histopathologic examination of leg tumor surrounding WA pellet. (A) H&E-stained section of leg tumor from F344 rat showing WA pellet hole (P); bar = 500 μm. (B) H&E-stained tumor section showing neoplastic infiltration of preexisting muscle fibers (MF); bar = 200 μm. (C) H&E-stained tumor section showing neoplastic cells with numerous mitoses (arrows) and bizarre mitotic figures (BZ); bar = 100 μm. (D) H&E-stained tumor section showing pleomorphic cell (arrow); bar = 100 μm. (E) Desmin staining of leg tumor showing neoplastic cells (NC) and muscle fibers (MF); bar = 500 μm. (F) Desmin staining of neoplastic cells; bar = 50 μm. |
PMC1257601_f2-ehp0113-000749_3454.jpg | What does this image primarily show? | Radiographic analysis of the Pb effects on fracture healing in group B mice (n = 6/group). Mice were continuously exposed to Pb in drinking water for 6 weeks, with X rays from representative mice taken at the indicated time after fracture. See “Materials and Methods” for details. Arrows indicate the radiolucency in the day-14 fracture callus of Pb-treated mice (E, F), which is absent in the unexposed animals (D). |
PMC1257601_f2-ehp0113-000749_3455.jpg | What can you see in this picture? | Radiographic analysis of the Pb effects on fracture healing in group B mice (n = 6/group). Mice were continuously exposed to Pb in drinking water for 6 weeks, with X rays from representative mice taken at the indicated time after fracture. See “Materials and Methods” for details. Arrows indicate the radiolucency in the day-14 fracture callus of Pb-treated mice (E, F), which is absent in the unexposed animals (D). |
PMC1257601_f2-ehp0113-000749_3453.jpg | What stands out most in this visual? | Radiographic analysis of the Pb effects on fracture healing in group B mice (n = 6/group). Mice were continuously exposed to Pb in drinking water for 6 weeks, with X rays from representative mice taken at the indicated time after fracture. See “Materials and Methods” for details. Arrows indicate the radiolucency in the day-14 fracture callus of Pb-treated mice (E, F), which is absent in the unexposed animals (D). |
PMC1257601_f2-ehp0113-000749_3452.jpg | Can you identify the primary element in this image? | Radiographic analysis of the Pb effects on fracture healing in group B mice (n = 6/group). Mice were continuously exposed to Pb in drinking water for 6 weeks, with X rays from representative mice taken at the indicated time after fracture. See “Materials and Methods” for details. Arrows indicate the radiolucency in the day-14 fracture callus of Pb-treated mice (E, F), which is absent in the unexposed animals (D). |
PMC1257601_f2-ehp0113-000749_3456.jpg | What is the core subject represented in this visual? | Radiographic analysis of the Pb effects on fracture healing in group B mice (n = 6/group). Mice were continuously exposed to Pb in drinking water for 6 weeks, with X rays from representative mice taken at the indicated time after fracture. See “Materials and Methods” for details. Arrows indicate the radiolucency in the day-14 fracture callus of Pb-treated mice (E, F), which is absent in the unexposed animals (D). |
PMC1257601_f2-ehp0113-000749_3459.jpg | What is the focal point of this photograph? | Radiographic analysis of the Pb effects on fracture healing in group B mice (n = 6/group). Mice were continuously exposed to Pb in drinking water for 6 weeks, with X rays from representative mice taken at the indicated time after fracture. See “Materials and Methods” for details. Arrows indicate the radiolucency in the day-14 fracture callus of Pb-treated mice (E, F), which is absent in the unexposed animals (D). |
PMC1257601_f2-ehp0113-000749_3460.jpg | What is the dominant medical problem in this image? | Radiographic analysis of the Pb effects on fracture healing in group B mice (n = 6/group). Mice were continuously exposed to Pb in drinking water for 6 weeks, with X rays from representative mice taken at the indicated time after fracture. See “Materials and Methods” for details. Arrows indicate the radiolucency in the day-14 fracture callus of Pb-treated mice (E, F), which is absent in the unexposed animals (D). |
PMC1257601_f3-ehp0113-000749_3466.jpg | What's the most prominent thing you notice in this picture? | Histologic analysis of the Pb effects on fracture healing in group B mice continuously exposed to Pb in drinking water for 6 weeks (n = 6/group). See “Materials and Methods” for details. ABH/OG histology sections are shown at 10× magnification. Note the large amount of Alcian blue–stained cartilage in the day-14 fracture callus of Pb-treated mice (E, F). The immature fracture callus has less cartilage and exhibits a more advanced stage of remodeling in the unexposed animals (D). |
PMC1257601_f3-ehp0113-000749_3469.jpg | What is shown in this image? | Histologic analysis of the Pb effects on fracture healing in group B mice continuously exposed to Pb in drinking water for 6 weeks (n = 6/group). See “Materials and Methods” for details. ABH/OG histology sections are shown at 10× magnification. Note the large amount of Alcian blue–stained cartilage in the day-14 fracture callus of Pb-treated mice (E, F). The immature fracture callus has less cartilage and exhibits a more advanced stage of remodeling in the unexposed animals (D). |
PMC1257601_f3-ehp0113-000749_3467.jpg | What does this image primarily show? | Histologic analysis of the Pb effects on fracture healing in group B mice continuously exposed to Pb in drinking water for 6 weeks (n = 6/group). See “Materials and Methods” for details. ABH/OG histology sections are shown at 10× magnification. Note the large amount of Alcian blue–stained cartilage in the day-14 fracture callus of Pb-treated mice (E, F). The immature fracture callus has less cartilage and exhibits a more advanced stage of remodeling in the unexposed animals (D). |
PMC1257601_f3-ehp0113-000749_3463.jpg | What is the focal point of this photograph? | Histologic analysis of the Pb effects on fracture healing in group B mice continuously exposed to Pb in drinking water for 6 weeks (n = 6/group). See “Materials and Methods” for details. ABH/OG histology sections are shown at 10× magnification. Note the large amount of Alcian blue–stained cartilage in the day-14 fracture callus of Pb-treated mice (E, F). The immature fracture callus has less cartilage and exhibits a more advanced stage of remodeling in the unexposed animals (D). |
PMC1257601_f3-ehp0113-000749_3464.jpg | What is the central feature of this picture? | Histologic analysis of the Pb effects on fracture healing in group B mice continuously exposed to Pb in drinking water for 6 weeks (n = 6/group). See “Materials and Methods” for details. ABH/OG histology sections are shown at 10× magnification. Note the large amount of Alcian blue–stained cartilage in the day-14 fracture callus of Pb-treated mice (E, F). The immature fracture callus has less cartilage and exhibits a more advanced stage of remodeling in the unexposed animals (D). |
PMC1257601_f3-ehp0113-000749_3461.jpg | What is the principal component of this image? | Histologic analysis of the Pb effects on fracture healing in group B mice continuously exposed to Pb in drinking water for 6 weeks (n = 6/group). See “Materials and Methods” for details. ABH/OG histology sections are shown at 10× magnification. Note the large amount of Alcian blue–stained cartilage in the day-14 fracture callus of Pb-treated mice (E, F). The immature fracture callus has less cartilage and exhibits a more advanced stage of remodeling in the unexposed animals (D). |
PMC1257601_f5-ehp0113-000749_3481.jpg | What key item or scene is captured in this photo? | Inhibition of cartilage maturation in day-14 fracture callus of group B mice continuously exposed to Pb in drinking water for 6 weeks (n = 6/group). Histology sections parallel to those presented in Figure 3D–F used for in situ hybridization to radiolabeled antisense probes for Col II (A–C), Col X (D–F), or osteocalcin (OC; G–I) or stained for TRAP (J–L). There is increased Col II signal in the middle of the Pb-exposed fracture callus (B, C) compared with controls, and there is an absence of Col X (E, F), osteocalcin (H, I), and TRAP (K, L) signal in this same region. |
PMC1257601_f5-ehp0113-000749_3480.jpg | What is being portrayed in this visual content? | Inhibition of cartilage maturation in day-14 fracture callus of group B mice continuously exposed to Pb in drinking water for 6 weeks (n = 6/group). Histology sections parallel to those presented in Figure 3D–F used for in situ hybridization to radiolabeled antisense probes for Col II (A–C), Col X (D–F), or osteocalcin (OC; G–I) or stained for TRAP (J–L). There is increased Col II signal in the middle of the Pb-exposed fracture callus (B, C) compared with controls, and there is an absence of Col X (E, F), osteocalcin (H, I), and TRAP (K, L) signal in this same region. |
PMC1257601_f5-ehp0113-000749_3475.jpg | What's the most prominent thing you notice in this picture? | Inhibition of cartilage maturation in day-14 fracture callus of group B mice continuously exposed to Pb in drinking water for 6 weeks (n = 6/group). Histology sections parallel to those presented in Figure 3D–F used for in situ hybridization to radiolabeled antisense probes for Col II (A–C), Col X (D–F), or osteocalcin (OC; G–I) or stained for TRAP (J–L). There is increased Col II signal in the middle of the Pb-exposed fracture callus (B, C) compared with controls, and there is an absence of Col X (E, F), osteocalcin (H, I), and TRAP (K, L) signal in this same region. |
PMC1257601_f5-ehp0113-000749_3482.jpg | What can you see in this picture? | Inhibition of cartilage maturation in day-14 fracture callus of group B mice continuously exposed to Pb in drinking water for 6 weeks (n = 6/group). Histology sections parallel to those presented in Figure 3D–F used for in situ hybridization to radiolabeled antisense probes for Col II (A–C), Col X (D–F), or osteocalcin (OC; G–I) or stained for TRAP (J–L). There is increased Col II signal in the middle of the Pb-exposed fracture callus (B, C) compared with controls, and there is an absence of Col X (E, F), osteocalcin (H, I), and TRAP (K, L) signal in this same region. |
PMC1257601_f5-ehp0113-000749_3474.jpg | What key item or scene is captured in this photo? | Inhibition of cartilage maturation in day-14 fracture callus of group B mice continuously exposed to Pb in drinking water for 6 weeks (n = 6/group). Histology sections parallel to those presented in Figure 3D–F used for in situ hybridization to radiolabeled antisense probes for Col II (A–C), Col X (D–F), or osteocalcin (OC; G–I) or stained for TRAP (J–L). There is increased Col II signal in the middle of the Pb-exposed fracture callus (B, C) compared with controls, and there is an absence of Col X (E, F), osteocalcin (H, I), and TRAP (K, L) signal in this same region. |
PMC1257601_f5-ehp0113-000749_3478.jpg | What is the main focus of this visual representation? | Inhibition of cartilage maturation in day-14 fracture callus of group B mice continuously exposed to Pb in drinking water for 6 weeks (n = 6/group). Histology sections parallel to those presented in Figure 3D–F used for in situ hybridization to radiolabeled antisense probes for Col II (A–C), Col X (D–F), or osteocalcin (OC; G–I) or stained for TRAP (J–L). There is increased Col II signal in the middle of the Pb-exposed fracture callus (B, C) compared with controls, and there is an absence of Col X (E, F), osteocalcin (H, I), and TRAP (K, L) signal in this same region. |
PMC1257601_f5-ehp0113-000749_3477.jpg | What is the focal point of this photograph? | Inhibition of cartilage maturation in day-14 fracture callus of group B mice continuously exposed to Pb in drinking water for 6 weeks (n = 6/group). Histology sections parallel to those presented in Figure 3D–F used for in situ hybridization to radiolabeled antisense probes for Col II (A–C), Col X (D–F), or osteocalcin (OC; G–I) or stained for TRAP (J–L). There is increased Col II signal in the middle of the Pb-exposed fracture callus (B, C) compared with controls, and there is an absence of Col X (E, F), osteocalcin (H, I), and TRAP (K, L) signal in this same region. |
PMC1257601_f5-ehp0113-000749_3473.jpg | Can you identify the primary element in this image? | Inhibition of cartilage maturation in day-14 fracture callus of group B mice continuously exposed to Pb in drinking water for 6 weeks (n = 6/group). Histology sections parallel to those presented in Figure 3D–F used for in situ hybridization to radiolabeled antisense probes for Col II (A–C), Col X (D–F), or osteocalcin (OC; G–I) or stained for TRAP (J–L). There is increased Col II signal in the middle of the Pb-exposed fracture callus (B, C) compared with controls, and there is an absence of Col X (E, F), osteocalcin (H, I), and TRAP (K, L) signal in this same region. |
PMC1257601_f6-ehp0113-000749_3471.jpg | What is the dominant medical problem in this image? | Pb exposure in group A mice (n = 4) exposed to 2,300 ppm Pb for 6 weeks, fractured, and assessed for skeletal repair. See “Materials and Methods” for details. A day-14 X ray from a representative mouse demonstrates the limited radiographic healing (arrow) in these mice (A). ABH/OG-stained histology section of day 21 fracture callus from a representative mouse at 10× (B) and 40× (C) magnification confirms the presence of fibrotic tissue between the fractured ends of the tibia and the complete absence of endochondral bone formation. These findings indicate a fibrous nonunion. |
PMC1257604_f3-ehp0113-000767_3484.jpg | What is shown in this image? | Thin-section CT scan of the chest showing ground glass opacities in the lung parenchyma, indicating interstitial inflammation and/or fibrosis. |
PMC1257648_f1-ehp0113-000871_3485.jpg | What is shown in this image? | Neurosphere plated on poly-d-lysine–coated slides showing differentiation and radial outgrowth of cells out of the sphere after 4 days in culture. Phase contrast image. Bar = 200 μm. |
PMC1257648_f1-ehp0113-000871_3486.jpg | What key item or scene is captured in this photo? | Neurosphere plated on poly-d-lysine–coated slides showing differentiation and radial outgrowth of cells out of the sphere after 4 days in culture. Phase contrast image. Bar = 200 μm. |
PMC1257667_f4-ehp0113-a00468_3488.jpg | What is shown in this image? | The hair of the mosquito that bit you? The antenna of the female Anopheles mosquito (above right and inset) bristles with various olfactory sensillae used for prey detection, flight direction, and egg laying. Laurence Zwiebel (above left, with mosquitoes) is targeting human-specific olfactory receptors in these mosquitoes. |
PMC1257667_f4-ehp0113-a00468_3487.jpg | What is the central feature of this picture? | The hair of the mosquito that bit you? The antenna of the female Anopheles mosquito (above right and inset) bristles with various olfactory sensillae used for prey detection, flight direction, and egg laying. Laurence Zwiebel (above left, with mosquitoes) is targeting human-specific olfactory receptors in these mosquitoes. |
PMC1260014_F1_3492.jpg | What can you see in this picture? | Patients with complete pathological response post-chemotherapy. CT scans of 3 patients showing residual pelvic mass after chemotherapy. Images a,c,e show CT scans pre-treatment, and images b,d,f are the post-treatment control studies. Notably, a patient (images e-f) shows a residual post-chemotherapy pelvic mass measuring 9 × 5 cm. |
PMC1260014_F1_3494.jpg | What is the main focus of this visual representation? | Patients with complete pathological response post-chemotherapy. CT scans of 3 patients showing residual pelvic mass after chemotherapy. Images a,c,e show CT scans pre-treatment, and images b,d,f are the post-treatment control studies. Notably, a patient (images e-f) shows a residual post-chemotherapy pelvic mass measuring 9 × 5 cm. |
PMC1260014_F1_3495.jpg | What is the main focus of this visual representation? | Patients with complete pathological response post-chemotherapy. CT scans of 3 patients showing residual pelvic mass after chemotherapy. Images a,c,e show CT scans pre-treatment, and images b,d,f are the post-treatment control studies. Notably, a patient (images e-f) shows a residual post-chemotherapy pelvic mass measuring 9 × 5 cm. |
PMC1260014_F1_3493.jpg | What is the central feature of this picture? | Patients with complete pathological response post-chemotherapy. CT scans of 3 patients showing residual pelvic mass after chemotherapy. Images a,c,e show CT scans pre-treatment, and images b,d,f are the post-treatment control studies. Notably, a patient (images e-f) shows a residual post-chemotherapy pelvic mass measuring 9 × 5 cm. |
PMC1260014_F1_3491.jpg | What is the core subject represented in this visual? | Patients with complete pathological response post-chemotherapy. CT scans of 3 patients showing residual pelvic mass after chemotherapy. Images a,c,e show CT scans pre-treatment, and images b,d,f are the post-treatment control studies. Notably, a patient (images e-f) shows a residual post-chemotherapy pelvic mass measuring 9 × 5 cm. |
PMC1260014_F1_3496.jpg | What is being portrayed in this visual content? | Patients with complete pathological response post-chemotherapy. CT scans of 3 patients showing residual pelvic mass after chemotherapy. Images a,c,e show CT scans pre-treatment, and images b,d,f are the post-treatment control studies. Notably, a patient (images e-f) shows a residual post-chemotherapy pelvic mass measuring 9 × 5 cm. |
PMC1260015_F6_3498.jpg | What key item or scene is captured in this photo? | Group of low grade Urothelial tumour cells obtained after centrifugation and smearing. Papanicolaou stain, x 400. |
PMC1261535_F1_3504.jpg | What is the focal point of this photograph? | Intrapulmonary arteries. A) laser-microdissection of small intrapulmonary arteries. 1) The laser cuts along the outer side of the tunica adventitia. 2) A sterile needle is used to isolate the vessel. 3) Needle with adherent vessel is lifted and transferred afterwards to a reaction tube. Magnification × 200. B) Representative intrapulmonary arteries during the process of vascular remodelling. 1) Under normoxic conditions. 2) At day 1 of hypoxia. 3) At day 7 of hypoxia. Smooth muscle cell layer causes vascular thickening. 4) At day 21 of hypoxia. Magnification × 200. |
PMC1261535_F1_3502.jpg | What is the core subject represented in this visual? | Intrapulmonary arteries. A) laser-microdissection of small intrapulmonary arteries. 1) The laser cuts along the outer side of the tunica adventitia. 2) A sterile needle is used to isolate the vessel. 3) Needle with adherent vessel is lifted and transferred afterwards to a reaction tube. Magnification × 200. B) Representative intrapulmonary arteries during the process of vascular remodelling. 1) Under normoxic conditions. 2) At day 1 of hypoxia. 3) At day 7 of hypoxia. Smooth muscle cell layer causes vascular thickening. 4) At day 21 of hypoxia. Magnification × 200. |
PMC1261535_F1_3501.jpg | What does this image primarily show? | Intrapulmonary arteries. A) laser-microdissection of small intrapulmonary arteries. 1) The laser cuts along the outer side of the tunica adventitia. 2) A sterile needle is used to isolate the vessel. 3) Needle with adherent vessel is lifted and transferred afterwards to a reaction tube. Magnification × 200. B) Representative intrapulmonary arteries during the process of vascular remodelling. 1) Under normoxic conditions. 2) At day 1 of hypoxia. 3) At day 7 of hypoxia. Smooth muscle cell layer causes vascular thickening. 4) At day 21 of hypoxia. Magnification × 200. |
PMC1261535_F1_3500.jpg | What is shown in this image? | Intrapulmonary arteries. A) laser-microdissection of small intrapulmonary arteries. 1) The laser cuts along the outer side of the tunica adventitia. 2) A sterile needle is used to isolate the vessel. 3) Needle with adherent vessel is lifted and transferred afterwards to a reaction tube. Magnification × 200. B) Representative intrapulmonary arteries during the process of vascular remodelling. 1) Under normoxic conditions. 2) At day 1 of hypoxia. 3) At day 7 of hypoxia. Smooth muscle cell layer causes vascular thickening. 4) At day 21 of hypoxia. Magnification × 200. |
PMC1261535_F1_3503.jpg | What stands out most in this visual? | Intrapulmonary arteries. A) laser-microdissection of small intrapulmonary arteries. 1) The laser cuts along the outer side of the tunica adventitia. 2) A sterile needle is used to isolate the vessel. 3) Needle with adherent vessel is lifted and transferred afterwards to a reaction tube. Magnification × 200. B) Representative intrapulmonary arteries during the process of vascular remodelling. 1) Under normoxic conditions. 2) At day 1 of hypoxia. 3) At day 7 of hypoxia. Smooth muscle cell layer causes vascular thickening. 4) At day 21 of hypoxia. Magnification × 200. |
PMC1261535_F1_3505.jpg | What is the central feature of this picture? | Intrapulmonary arteries. A) laser-microdissection of small intrapulmonary arteries. 1) The laser cuts along the outer side of the tunica adventitia. 2) A sterile needle is used to isolate the vessel. 3) Needle with adherent vessel is lifted and transferred afterwards to a reaction tube. Magnification × 200. B) Representative intrapulmonary arteries during the process of vascular remodelling. 1) Under normoxic conditions. 2) At day 1 of hypoxia. 3) At day 7 of hypoxia. Smooth muscle cell layer causes vascular thickening. 4) At day 21 of hypoxia. Magnification × 200. |
PMC1261536_F1_3508.jpg | What's the most prominent thing you notice in this picture? | Cryostat sections of bronchial biopsies stained with antibodies against the ln α3 chain. Allergic asthma (A), non-allergic asthma (B) and healthy control (C) (original magnification ×170). The comparison of the thickness of SEBM is shown and the significant differences between the groups shown in the figure. Mayer's hematoxylin. |
PMC1261536_F1_3507.jpg | What is the main focus of this visual representation? | Cryostat sections of bronchial biopsies stained with antibodies against the ln α3 chain. Allergic asthma (A), non-allergic asthma (B) and healthy control (C) (original magnification ×170). The comparison of the thickness of SEBM is shown and the significant differences between the groups shown in the figure. Mayer's hematoxylin. |
PMC1261536_F1_3506.jpg | What is the principal component of this image? | Cryostat sections of bronchial biopsies stained with antibodies against the ln α3 chain. Allergic asthma (A), non-allergic asthma (B) and healthy control (C) (original magnification ×170). The comparison of the thickness of SEBM is shown and the significant differences between the groups shown in the figure. Mayer's hematoxylin. |
PMC1261536_F2_3512.jpg | What's the most prominent thing you notice in this picture? | Cryostat sections of bronchial biopsies stained with antibodies against the ln α5 chain. Allergic asthma (A), non-allergic asthma (B) and healthy control (C) (original magnification ×170). The comparison of the thickness of SEBM is shown and the significant differences between the groups shown in the figure. Mayer's hematoxylin. |
PMC1261536_F2_3510.jpg | Describe the main subject of this image. | Cryostat sections of bronchial biopsies stained with antibodies against the ln α5 chain. Allergic asthma (A), non-allergic asthma (B) and healthy control (C) (original magnification ×170). The comparison of the thickness of SEBM is shown and the significant differences between the groups shown in the figure. Mayer's hematoxylin. |
PMC1261536_F2_3511.jpg | What does this image primarily show? | Cryostat sections of bronchial biopsies stained with antibodies against the ln α5 chain. Allergic asthma (A), non-allergic asthma (B) and healthy control (C) (original magnification ×170). The comparison of the thickness of SEBM is shown and the significant differences between the groups shown in the figure. Mayer's hematoxylin. |
PMC1261536_F3_3515.jpg | What's the most prominent thing you notice in this picture? | Cryostat sections of bronchial biopsies stained with antibodies against the ln γ1 chain. Allergic asthma (A), non-allergic asthma (B) and healthy control (C) (original magnification ×170). The comparison of the thickness of SEBM is shown and the significant differences between the groups shown in the figure. Mayer's hematoxylin. |
PMC1261536_F3_3516.jpg | What is the focal point of this photograph? | Cryostat sections of bronchial biopsies stained with antibodies against the ln γ1 chain. Allergic asthma (A), non-allergic asthma (B) and healthy control (C) (original magnification ×170). The comparison of the thickness of SEBM is shown and the significant differences between the groups shown in the figure. Mayer's hematoxylin. |
PMC1261536_F4_3519.jpg | Can you identify the primary element in this image? | Cryostat sections of bronchial biopsies stained with antibodies against the ln γ2 chain. Allergic asthma (A), non-allergic asthma (B) and healthy control (C) (original magnification ×170). As shown in the figure epithelial staining was found both in the apical part of the columnar epithelium and in the basal cells. Staining of the apical part of the columnar epithelium was only found in intact epithelium from allergic asthmatics. The comparison of the thickness of SEBM is shown and the significant differences between the groups shown in the figure. Mayer's hematoxylin. |
PMC1261536_F4_3520.jpg | What is the dominant medical problem in this image? | Cryostat sections of bronchial biopsies stained with antibodies against the ln γ2 chain. Allergic asthma (A), non-allergic asthma (B) and healthy control (C) (original magnification ×170). As shown in the figure epithelial staining was found both in the apical part of the columnar epithelium and in the basal cells. Staining of the apical part of the columnar epithelium was only found in intact epithelium from allergic asthmatics. The comparison of the thickness of SEBM is shown and the significant differences between the groups shown in the figure. Mayer's hematoxylin. |
PMC1261536_F4_3518.jpg | What is shown in this image? | Cryostat sections of bronchial biopsies stained with antibodies against the ln γ2 chain. Allergic asthma (A), non-allergic asthma (B) and healthy control (C) (original magnification ×170). As shown in the figure epithelial staining was found both in the apical part of the columnar epithelium and in the basal cells. Staining of the apical part of the columnar epithelium was only found in intact epithelium from allergic asthmatics. The comparison of the thickness of SEBM is shown and the significant differences between the groups shown in the figure. Mayer's hematoxylin. |
PMC1261538_F1_3522.jpg | What's the most prominent thing you notice in this picture? | CT scan showing lesion in the pancreas. |
PMC1261538_F2_3523.jpg | What object or scene is depicted here? | MRI showing cystic and solid lesion in the pancreas. |
PMC1262624_ppat-0010017-g005_3531.jpg | What is the main focus of this visual representation? | Localization of TgAMA1 and RON4 During InvasionTachyzoites were allowed to invade following a potassium shift as for Figure 4. DICA, E, and I) and deconvolution IIF were then used to image formaldehyde-fixed parasites as described in Figure 3, except that the monolayers were permeabilized at the outset and a mAb specific for the cytoplasmic tail of TgAMA1 (CL22) was used in place of anti-SAG1. The images shown here are three-dimensional reconstructions from forty 0.1-μm sections.(A–D) show a wild-type parasite that is about 40% inside the host cell (the outside portion shows a bright, posterior cap of CL22 staining). (E) shows the axis of rotation for the reconstruction, and the new view of the IIF images present in (B–D) are shown in the corresponding panels (F–H). Images (I–L) show a ΔAMA1/AMA1-myc parasite with low surface AMA1 signal (no posterior cap) that is about 80% invaded into its vacuole. The MJ is indicated by an arrow. |
PMC1262624_ppat-0010017-g005_3533.jpg | What's the most prominent thing you notice in this picture? | Localization of TgAMA1 and RON4 During InvasionTachyzoites were allowed to invade following a potassium shift as for Figure 4. DICA, E, and I) and deconvolution IIF were then used to image formaldehyde-fixed parasites as described in Figure 3, except that the monolayers were permeabilized at the outset and a mAb specific for the cytoplasmic tail of TgAMA1 (CL22) was used in place of anti-SAG1. The images shown here are three-dimensional reconstructions from forty 0.1-μm sections.(A–D) show a wild-type parasite that is about 40% inside the host cell (the outside portion shows a bright, posterior cap of CL22 staining). (E) shows the axis of rotation for the reconstruction, and the new view of the IIF images present in (B–D) are shown in the corresponding panels (F–H). Images (I–L) show a ΔAMA1/AMA1-myc parasite with low surface AMA1 signal (no posterior cap) that is about 80% invaded into its vacuole. The MJ is indicated by an arrow. |
PMC1262624_ppat-0010017-g005_3529.jpg | Can you identify the primary element in this image? | Localization of TgAMA1 and RON4 During InvasionTachyzoites were allowed to invade following a potassium shift as for Figure 4. DICA, E, and I) and deconvolution IIF were then used to image formaldehyde-fixed parasites as described in Figure 3, except that the monolayers were permeabilized at the outset and a mAb specific for the cytoplasmic tail of TgAMA1 (CL22) was used in place of anti-SAG1. The images shown here are three-dimensional reconstructions from forty 0.1-μm sections.(A–D) show a wild-type parasite that is about 40% inside the host cell (the outside portion shows a bright, posterior cap of CL22 staining). (E) shows the axis of rotation for the reconstruction, and the new view of the IIF images present in (B–D) are shown in the corresponding panels (F–H). Images (I–L) show a ΔAMA1/AMA1-myc parasite with low surface AMA1 signal (no posterior cap) that is about 80% invaded into its vacuole. The MJ is indicated by an arrow. |
PMC1262624_ppat-0010017-g005_3528.jpg | What is the main focus of this visual representation? | Localization of TgAMA1 and RON4 During InvasionTachyzoites were allowed to invade following a potassium shift as for Figure 4. DICA, E, and I) and deconvolution IIF were then used to image formaldehyde-fixed parasites as described in Figure 3, except that the monolayers were permeabilized at the outset and a mAb specific for the cytoplasmic tail of TgAMA1 (CL22) was used in place of anti-SAG1. The images shown here are three-dimensional reconstructions from forty 0.1-μm sections.(A–D) show a wild-type parasite that is about 40% inside the host cell (the outside portion shows a bright, posterior cap of CL22 staining). (E) shows the axis of rotation for the reconstruction, and the new view of the IIF images present in (B–D) are shown in the corresponding panels (F–H). Images (I–L) show a ΔAMA1/AMA1-myc parasite with low surface AMA1 signal (no posterior cap) that is about 80% invaded into its vacuole. The MJ is indicated by an arrow. |
PMC1262624_ppat-0010017-g005_3535.jpg | What is the main focus of this visual representation? | Localization of TgAMA1 and RON4 During InvasionTachyzoites were allowed to invade following a potassium shift as for Figure 4. DICA, E, and I) and deconvolution IIF were then used to image formaldehyde-fixed parasites as described in Figure 3, except that the monolayers were permeabilized at the outset and a mAb specific for the cytoplasmic tail of TgAMA1 (CL22) was used in place of anti-SAG1. The images shown here are three-dimensional reconstructions from forty 0.1-μm sections.(A–D) show a wild-type parasite that is about 40% inside the host cell (the outside portion shows a bright, posterior cap of CL22 staining). (E) shows the axis of rotation for the reconstruction, and the new view of the IIF images present in (B–D) are shown in the corresponding panels (F–H). Images (I–L) show a ΔAMA1/AMA1-myc parasite with low surface AMA1 signal (no posterior cap) that is about 80% invaded into its vacuole. The MJ is indicated by an arrow. |
PMC1262624_ppat-0010017-g005_3524.jpg | What is the main focus of this visual representation? | Localization of TgAMA1 and RON4 During InvasionTachyzoites were allowed to invade following a potassium shift as for Figure 4. DICA, E, and I) and deconvolution IIF were then used to image formaldehyde-fixed parasites as described in Figure 3, except that the monolayers were permeabilized at the outset and a mAb specific for the cytoplasmic tail of TgAMA1 (CL22) was used in place of anti-SAG1. The images shown here are three-dimensional reconstructions from forty 0.1-μm sections.(A–D) show a wild-type parasite that is about 40% inside the host cell (the outside portion shows a bright, posterior cap of CL22 staining). (E) shows the axis of rotation for the reconstruction, and the new view of the IIF images present in (B–D) are shown in the corresponding panels (F–H). Images (I–L) show a ΔAMA1/AMA1-myc parasite with low surface AMA1 signal (no posterior cap) that is about 80% invaded into its vacuole. The MJ is indicated by an arrow. |
PMC1262624_ppat-0010017-g005_3530.jpg | Describe the main subject of this image. | Localization of TgAMA1 and RON4 During InvasionTachyzoites were allowed to invade following a potassium shift as for Figure 4. DICA, E, and I) and deconvolution IIF were then used to image formaldehyde-fixed parasites as described in Figure 3, except that the monolayers were permeabilized at the outset and a mAb specific for the cytoplasmic tail of TgAMA1 (CL22) was used in place of anti-SAG1. The images shown here are three-dimensional reconstructions from forty 0.1-μm sections.(A–D) show a wild-type parasite that is about 40% inside the host cell (the outside portion shows a bright, posterior cap of CL22 staining). (E) shows the axis of rotation for the reconstruction, and the new view of the IIF images present in (B–D) are shown in the corresponding panels (F–H). Images (I–L) show a ΔAMA1/AMA1-myc parasite with low surface AMA1 signal (no posterior cap) that is about 80% invaded into its vacuole. The MJ is indicated by an arrow. |
PMC1262624_ppat-0010017-g005_3526.jpg | What does this image primarily show? | Localization of TgAMA1 and RON4 During InvasionTachyzoites were allowed to invade following a potassium shift as for Figure 4. DICA, E, and I) and deconvolution IIF were then used to image formaldehyde-fixed parasites as described in Figure 3, except that the monolayers were permeabilized at the outset and a mAb specific for the cytoplasmic tail of TgAMA1 (CL22) was used in place of anti-SAG1. The images shown here are three-dimensional reconstructions from forty 0.1-μm sections.(A–D) show a wild-type parasite that is about 40% inside the host cell (the outside portion shows a bright, posterior cap of CL22 staining). (E) shows the axis of rotation for the reconstruction, and the new view of the IIF images present in (B–D) are shown in the corresponding panels (F–H). Images (I–L) show a ΔAMA1/AMA1-myc parasite with low surface AMA1 signal (no posterior cap) that is about 80% invaded into its vacuole. The MJ is indicated by an arrow. |
PMC1262628_pbio-0030374-g002_3537.jpg | What is the core subject represented in this visual? | Differential Recruitment of Endogenous Pre-RNA Splicing Factors to Alternatively Spliced Transcripts(A) Recruitment of splicing factors to tau transcription sites detected by combined RNA-FISH using specific probes against the tau minigene (green) and IF microscopy with specific anti-splicing factor antibodies (red). Arrowheads indicate tau transcription sites. All associations were confirmed by linescan analysis. Scale bar = 2.5 μm. (Inset: higher magnifications of the transcription site) Lines indicate the location of the linescans.(B) Quantitation of percentage of cells with colocalization of tau RNA-FISH and splicing factor signals. Values represent averages from at least 100 transcription sites from at least three experiments ± SEM. |
PMC1262628_pbio-0030374-g002_3543.jpg | Can you identify the primary element in this image? | Differential Recruitment of Endogenous Pre-RNA Splicing Factors to Alternatively Spliced Transcripts(A) Recruitment of splicing factors to tau transcription sites detected by combined RNA-FISH using specific probes against the tau minigene (green) and IF microscopy with specific anti-splicing factor antibodies (red). Arrowheads indicate tau transcription sites. All associations were confirmed by linescan analysis. Scale bar = 2.5 μm. (Inset: higher magnifications of the transcription site) Lines indicate the location of the linescans.(B) Quantitation of percentage of cells with colocalization of tau RNA-FISH and splicing factor signals. Values represent averages from at least 100 transcription sites from at least three experiments ± SEM. |
PMC1262628_pbio-0030374-g002_3539.jpg | What is the main focus of this visual representation? | Differential Recruitment of Endogenous Pre-RNA Splicing Factors to Alternatively Spliced Transcripts(A) Recruitment of splicing factors to tau transcription sites detected by combined RNA-FISH using specific probes against the tau minigene (green) and IF microscopy with specific anti-splicing factor antibodies (red). Arrowheads indicate tau transcription sites. All associations were confirmed by linescan analysis. Scale bar = 2.5 μm. (Inset: higher magnifications of the transcription site) Lines indicate the location of the linescans.(B) Quantitation of percentage of cells with colocalization of tau RNA-FISH and splicing factor signals. Values represent averages from at least 100 transcription sites from at least three experiments ± SEM. |
PMC1262628_pbio-0030374-g002_3541.jpg | Can you identify the primary element in this image? | Differential Recruitment of Endogenous Pre-RNA Splicing Factors to Alternatively Spliced Transcripts(A) Recruitment of splicing factors to tau transcription sites detected by combined RNA-FISH using specific probes against the tau minigene (green) and IF microscopy with specific anti-splicing factor antibodies (red). Arrowheads indicate tau transcription sites. All associations were confirmed by linescan analysis. Scale bar = 2.5 μm. (Inset: higher magnifications of the transcription site) Lines indicate the location of the linescans.(B) Quantitation of percentage of cells with colocalization of tau RNA-FISH and splicing factor signals. Values represent averages from at least 100 transcription sites from at least three experiments ± SEM. |
PMC1262630_pbio-0030391-g001_3546.jpg | What is the principal component of this image? | Confocal microscopy was used to determine the cytoplasmic volume of T cells to infer concentrations of signaling molecules in the cytoplasm |
PMC1262738_F3_3554.jpg | What stands out most in this visual? | Hg-SIL : presence of inflammatory cells which did not influenced the lecture (Papanicolaou stain, high magnification – 20x objective, Turbitec® system). HCII was positive. |
PMC1262761_F5_3555.jpg | Can you identify the primary element in this image? | TEM-analysis of ultra-thin section of a yeast transformant expressing mSbsC-EGFP. (A) mSbsC-EGFP expressing yeast spheroplast showing rod like structures (*). (B) Immunocytochemistry of mSbsC-EGFP expressing yeast cell using antibodies against GFP. (C) Negative staining of osmotically shocked yeast protoplasts expressing mSbsC-EGFP showing in vivo formed assembly products with similar structures (*) as in Fig 2, the inset and image (D) show a higher magnification of these structures, a lattice is discernible. Key: M-mitochondrion, N-nucleus, V-vacuole. The bar represents 1 μm, for the inset 100 nm. |
PMC1262761_F5_3558.jpg | What can you see in this picture? | TEM-analysis of ultra-thin section of a yeast transformant expressing mSbsC-EGFP. (A) mSbsC-EGFP expressing yeast spheroplast showing rod like structures (*). (B) Immunocytochemistry of mSbsC-EGFP expressing yeast cell using antibodies against GFP. (C) Negative staining of osmotically shocked yeast protoplasts expressing mSbsC-EGFP showing in vivo formed assembly products with similar structures (*) as in Fig 2, the inset and image (D) show a higher magnification of these structures, a lattice is discernible. Key: M-mitochondrion, N-nucleus, V-vacuole. The bar represents 1 μm, for the inset 100 nm. |
PMC1262761_F5_3557.jpg | What is the principal component of this image? | TEM-analysis of ultra-thin section of a yeast transformant expressing mSbsC-EGFP. (A) mSbsC-EGFP expressing yeast spheroplast showing rod like structures (*). (B) Immunocytochemistry of mSbsC-EGFP expressing yeast cell using antibodies against GFP. (C) Negative staining of osmotically shocked yeast protoplasts expressing mSbsC-EGFP showing in vivo formed assembly products with similar structures (*) as in Fig 2, the inset and image (D) show a higher magnification of these structures, a lattice is discernible. Key: M-mitochondrion, N-nucleus, V-vacuole. The bar represents 1 μm, for the inset 100 nm. |
PMC1262771_F1_3567.jpg | What is the main focus of this visual representation? | Immunohistochemical staining for Ki67, TGF-β1 and apoptosis by TUNEL in explants of human endometrium throughout the menstrual cycle obtained from normal (A, C, E, G, I, J and K) and endometriosis (B, D, F, H and L) women. Representative human endometrium explants from (A, B, E, F and I) proliferative phase and (C, D, G, H, J, K and L) secretory phase of the menstrual cycle with positive immuno-staining for (A-D) Ki67 and (E-H) TGF-β1 or positive DNA fragmentation by TUNEL (K and L). Immunohistochemitry (I) and TUNEL (J) negative controls. Cell nuclei are stained with haematoxylin (immunohistochemitry) or propidium iodine (TUNEL). g: glandular, s: stroma, rc: red blood cell. Magnification, 400×. |
PMC1262771_F1_3568.jpg | What can you see in this picture? | Immunohistochemical staining for Ki67, TGF-β1 and apoptosis by TUNEL in explants of human endometrium throughout the menstrual cycle obtained from normal (A, C, E, G, I, J and K) and endometriosis (B, D, F, H and L) women. Representative human endometrium explants from (A, B, E, F and I) proliferative phase and (C, D, G, H, J, K and L) secretory phase of the menstrual cycle with positive immuno-staining for (A-D) Ki67 and (E-H) TGF-β1 or positive DNA fragmentation by TUNEL (K and L). Immunohistochemitry (I) and TUNEL (J) negative controls. Cell nuclei are stained with haematoxylin (immunohistochemitry) or propidium iodine (TUNEL). g: glandular, s: stroma, rc: red blood cell. Magnification, 400×. |
PMC1262771_F1_3559.jpg | What is the dominant medical problem in this image? | Immunohistochemical staining for Ki67, TGF-β1 and apoptosis by TUNEL in explants of human endometrium throughout the menstrual cycle obtained from normal (A, C, E, G, I, J and K) and endometriosis (B, D, F, H and L) women. Representative human endometrium explants from (A, B, E, F and I) proliferative phase and (C, D, G, H, J, K and L) secretory phase of the menstrual cycle with positive immuno-staining for (A-D) Ki67 and (E-H) TGF-β1 or positive DNA fragmentation by TUNEL (K and L). Immunohistochemitry (I) and TUNEL (J) negative controls. Cell nuclei are stained with haematoxylin (immunohistochemitry) or propidium iodine (TUNEL). g: glandular, s: stroma, rc: red blood cell. Magnification, 400×. |
PMC1262771_F1_3563.jpg | What's the most prominent thing you notice in this picture? | Immunohistochemical staining for Ki67, TGF-β1 and apoptosis by TUNEL in explants of human endometrium throughout the menstrual cycle obtained from normal (A, C, E, G, I, J and K) and endometriosis (B, D, F, H and L) women. Representative human endometrium explants from (A, B, E, F and I) proliferative phase and (C, D, G, H, J, K and L) secretory phase of the menstrual cycle with positive immuno-staining for (A-D) Ki67 and (E-H) TGF-β1 or positive DNA fragmentation by TUNEL (K and L). Immunohistochemitry (I) and TUNEL (J) negative controls. Cell nuclei are stained with haematoxylin (immunohistochemitry) or propidium iodine (TUNEL). g: glandular, s: stroma, rc: red blood cell. Magnification, 400×. |
PMC1262771_F1_3564.jpg | What can you see in this picture? | Immunohistochemical staining for Ki67, TGF-β1 and apoptosis by TUNEL in explants of human endometrium throughout the menstrual cycle obtained from normal (A, C, E, G, I, J and K) and endometriosis (B, D, F, H and L) women. Representative human endometrium explants from (A, B, E, F and I) proliferative phase and (C, D, G, H, J, K and L) secretory phase of the menstrual cycle with positive immuno-staining for (A-D) Ki67 and (E-H) TGF-β1 or positive DNA fragmentation by TUNEL (K and L). Immunohistochemitry (I) and TUNEL (J) negative controls. Cell nuclei are stained with haematoxylin (immunohistochemitry) or propidium iodine (TUNEL). g: glandular, s: stroma, rc: red blood cell. Magnification, 400×. |
PMC1262771_F1_3565.jpg | What is the dominant medical problem in this image? | Immunohistochemical staining for Ki67, TGF-β1 and apoptosis by TUNEL in explants of human endometrium throughout the menstrual cycle obtained from normal (A, C, E, G, I, J and K) and endometriosis (B, D, F, H and L) women. Representative human endometrium explants from (A, B, E, F and I) proliferative phase and (C, D, G, H, J, K and L) secretory phase of the menstrual cycle with positive immuno-staining for (A-D) Ki67 and (E-H) TGF-β1 or positive DNA fragmentation by TUNEL (K and L). Immunohistochemitry (I) and TUNEL (J) negative controls. Cell nuclei are stained with haematoxylin (immunohistochemitry) or propidium iodine (TUNEL). g: glandular, s: stroma, rc: red blood cell. Magnification, 400×. |
PMC1262771_F1_3562.jpg | What is the central feature of this picture? | Immunohistochemical staining for Ki67, TGF-β1 and apoptosis by TUNEL in explants of human endometrium throughout the menstrual cycle obtained from normal (A, C, E, G, I, J and K) and endometriosis (B, D, F, H and L) women. Representative human endometrium explants from (A, B, E, F and I) proliferative phase and (C, D, G, H, J, K and L) secretory phase of the menstrual cycle with positive immuno-staining for (A-D) Ki67 and (E-H) TGF-β1 or positive DNA fragmentation by TUNEL (K and L). Immunohistochemitry (I) and TUNEL (J) negative controls. Cell nuclei are stained with haematoxylin (immunohistochemitry) or propidium iodine (TUNEL). g: glandular, s: stroma, rc: red blood cell. Magnification, 400×. |
PMC1262771_F1_3569.jpg | What can you see in this picture? | Immunohistochemical staining for Ki67, TGF-β1 and apoptosis by TUNEL in explants of human endometrium throughout the menstrual cycle obtained from normal (A, C, E, G, I, J and K) and endometriosis (B, D, F, H and L) women. Representative human endometrium explants from (A, B, E, F and I) proliferative phase and (C, D, G, H, J, K and L) secretory phase of the menstrual cycle with positive immuno-staining for (A-D) Ki67 and (E-H) TGF-β1 or positive DNA fragmentation by TUNEL (K and L). Immunohistochemitry (I) and TUNEL (J) negative controls. Cell nuclei are stained with haematoxylin (immunohistochemitry) or propidium iodine (TUNEL). g: glandular, s: stroma, rc: red blood cell. Magnification, 400×. |
PMC1262771_F1_3570.jpg | What is the central feature of this picture? | Immunohistochemical staining for Ki67, TGF-β1 and apoptosis by TUNEL in explants of human endometrium throughout the menstrual cycle obtained from normal (A, C, E, G, I, J and K) and endometriosis (B, D, F, H and L) women. Representative human endometrium explants from (A, B, E, F and I) proliferative phase and (C, D, G, H, J, K and L) secretory phase of the menstrual cycle with positive immuno-staining for (A-D) Ki67 and (E-H) TGF-β1 or positive DNA fragmentation by TUNEL (K and L). Immunohistochemitry (I) and TUNEL (J) negative controls. Cell nuclei are stained with haematoxylin (immunohistochemitry) or propidium iodine (TUNEL). g: glandular, s: stroma, rc: red blood cell. Magnification, 400×. |
PMC1262772_F3_3573.jpg | What is the principal component of this image? | Connexin 43 expression and histology of representative cultured follicles. (A and B) Encapsulated follicle in the absence of FSH, (C and D) Unencapsulated follicle grown in FSH supplemented media, (E and F) Encapsulated follicle with FSH present in both the media and the bead, (G) Connexin staining in preantral follicle of an intact ovary section. (H) Negative control for the immunohistochemical staining, serial section from the same follicle as in C. A, C, E, G, H, represent connexin immunohistochemistry. B, D, and F are H&E stained follicle sections. In panel C, white line is location of basement membrane. Scale bars represents 50 μm in length. |
PMC1262772_F3_3572.jpg | What is the central feature of this picture? | Connexin 43 expression and histology of representative cultured follicles. (A and B) Encapsulated follicle in the absence of FSH, (C and D) Unencapsulated follicle grown in FSH supplemented media, (E and F) Encapsulated follicle with FSH present in both the media and the bead, (G) Connexin staining in preantral follicle of an intact ovary section. (H) Negative control for the immunohistochemical staining, serial section from the same follicle as in C. A, C, E, G, H, represent connexin immunohistochemistry. B, D, and F are H&E stained follicle sections. In panel C, white line is location of basement membrane. Scale bars represents 50 μm in length. |
PMC1262772_F3_3576.jpg | What is the dominant medical problem in this image? | Connexin 43 expression and histology of representative cultured follicles. (A and B) Encapsulated follicle in the absence of FSH, (C and D) Unencapsulated follicle grown in FSH supplemented media, (E and F) Encapsulated follicle with FSH present in both the media and the bead, (G) Connexin staining in preantral follicle of an intact ovary section. (H) Negative control for the immunohistochemical staining, serial section from the same follicle as in C. A, C, E, G, H, represent connexin immunohistochemistry. B, D, and F are H&E stained follicle sections. In panel C, white line is location of basement membrane. Scale bars represents 50 μm in length. |
PMC1262772_F3_3571.jpg | What is the principal component of this image? | Connexin 43 expression and histology of representative cultured follicles. (A and B) Encapsulated follicle in the absence of FSH, (C and D) Unencapsulated follicle grown in FSH supplemented media, (E and F) Encapsulated follicle with FSH present in both the media and the bead, (G) Connexin staining in preantral follicle of an intact ovary section. (H) Negative control for the immunohistochemical staining, serial section from the same follicle as in C. A, C, E, G, H, represent connexin immunohistochemistry. B, D, and F are H&E stained follicle sections. In panel C, white line is location of basement membrane. Scale bars represents 50 μm in length. |
PMC1262772_F3_3578.jpg | Describe the main subject of this image. | Connexin 43 expression and histology of representative cultured follicles. (A and B) Encapsulated follicle in the absence of FSH, (C and D) Unencapsulated follicle grown in FSH supplemented media, (E and F) Encapsulated follicle with FSH present in both the media and the bead, (G) Connexin staining in preantral follicle of an intact ovary section. (H) Negative control for the immunohistochemical staining, serial section from the same follicle as in C. A, C, E, G, H, represent connexin immunohistochemistry. B, D, and F are H&E stained follicle sections. In panel C, white line is location of basement membrane. Scale bars represents 50 μm in length. |
PMC1262776_F3_3583.jpg | What key item or scene is captured in this photo? | Effect of p10-CA mutations on virus particle morphology. WT (top left and right), M239F (middle left and right), and M239G (bottom left and right) viruses from transfected cells were sedimented through 20% sucrose cushions, resuspended, and processed for electron microscopy. At low magnification (left; top, middle and bottom), WT and M239F cores appeared conical or bullet-shaped, whereas M239G cores sometimes appeared conical (left-bottom, leftmost virus), but more often appeared with large misshapen cores. At higher magnification (right; top, middle and bottom), internal cores were difficult to discern without significant adjustment of image contrast levels. Size bars for the two magnifications of images appear in bottom left and right panels, and correspond to 100 nm. |
PMC1262776_F3_3579.jpg | What stands out most in this visual? | Effect of p10-CA mutations on virus particle morphology. WT (top left and right), M239F (middle left and right), and M239G (bottom left and right) viruses from transfected cells were sedimented through 20% sucrose cushions, resuspended, and processed for electron microscopy. At low magnification (left; top, middle and bottom), WT and M239F cores appeared conical or bullet-shaped, whereas M239G cores sometimes appeared conical (left-bottom, leftmost virus), but more often appeared with large misshapen cores. At higher magnification (right; top, middle and bottom), internal cores were difficult to discern without significant adjustment of image contrast levels. Size bars for the two magnifications of images appear in bottom left and right panels, and correspond to 100 nm. |
PMC1262776_F3_3582.jpg | What object or scene is depicted here? | Effect of p10-CA mutations on virus particle morphology. WT (top left and right), M239F (middle left and right), and M239G (bottom left and right) viruses from transfected cells were sedimented through 20% sucrose cushions, resuspended, and processed for electron microscopy. At low magnification (left; top, middle and bottom), WT and M239F cores appeared conical or bullet-shaped, whereas M239G cores sometimes appeared conical (left-bottom, leftmost virus), but more often appeared with large misshapen cores. At higher magnification (right; top, middle and bottom), internal cores were difficult to discern without significant adjustment of image contrast levels. Size bars for the two magnifications of images appear in bottom left and right panels, and correspond to 100 nm. |
PMC1262776_F3_3580.jpg | What's the most prominent thing you notice in this picture? | Effect of p10-CA mutations on virus particle morphology. WT (top left and right), M239F (middle left and right), and M239G (bottom left and right) viruses from transfected cells were sedimented through 20% sucrose cushions, resuspended, and processed for electron microscopy. At low magnification (left; top, middle and bottom), WT and M239F cores appeared conical or bullet-shaped, whereas M239G cores sometimes appeared conical (left-bottom, leftmost virus), but more often appeared with large misshapen cores. At higher magnification (right; top, middle and bottom), internal cores were difficult to discern without significant adjustment of image contrast levels. Size bars for the two magnifications of images appear in bottom left and right panels, and correspond to 100 nm. |
PMC1266025_F4_3592.jpg | What is the principal component of this image? | Immunofluorescent staining of EphB4 in prostate cancer cell lines. Immunofluorescent staining of EphB4 in prostate cancer cell lines showing diffuse staining on the surface and in the cytoplasm of LNCaP and DU145 and in the cytoplasm only of PC3. There was no reactivity to the primary antibody (EphB4 1° only) or secondary antibody (2° only) alone and little background fluorescence (No staining). |
PMC1266025_F4_3587.jpg | What is the core subject represented in this visual? | Immunofluorescent staining of EphB4 in prostate cancer cell lines. Immunofluorescent staining of EphB4 in prostate cancer cell lines showing diffuse staining on the surface and in the cytoplasm of LNCaP and DU145 and in the cytoplasm only of PC3. There was no reactivity to the primary antibody (EphB4 1° only) or secondary antibody (2° only) alone and little background fluorescence (No staining). |
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