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PMC1266025_F4_3594.jpg | What is being portrayed in this visual content? | Immunofluorescent staining of EphB4 in prostate cancer cell lines. Immunofluorescent staining of EphB4 in prostate cancer cell lines showing diffuse staining on the surface and in the cytoplasm of LNCaP and DU145 and in the cytoplasm only of PC3. There was no reactivity to the primary antibody (EphB4 1° only) or secondary antibody (2° only) alone and little background fluorescence (No staining). |
PMC1266025_F4_3589.jpg | What's the most prominent thing you notice in this picture? | Immunofluorescent staining of EphB4 in prostate cancer cell lines. Immunofluorescent staining of EphB4 in prostate cancer cell lines showing diffuse staining on the surface and in the cytoplasm of LNCaP and DU145 and in the cytoplasm only of PC3. There was no reactivity to the primary antibody (EphB4 1° only) or secondary antibody (2° only) alone and little background fluorescence (No staining). |
PMC1266025_F4_3595.jpg | What is the focal point of this photograph? | Immunofluorescent staining of EphB4 in prostate cancer cell lines. Immunofluorescent staining of EphB4 in prostate cancer cell lines showing diffuse staining on the surface and in the cytoplasm of LNCaP and DU145 and in the cytoplasm only of PC3. There was no reactivity to the primary antibody (EphB4 1° only) or secondary antibody (2° only) alone and little background fluorescence (No staining). |
PMC1266025_F4_3585.jpg | What does this image primarily show? | Immunofluorescent staining of EphB4 in prostate cancer cell lines. Immunofluorescent staining of EphB4 in prostate cancer cell lines showing diffuse staining on the surface and in the cytoplasm of LNCaP and DU145 and in the cytoplasm only of PC3. There was no reactivity to the primary antibody (EphB4 1° only) or secondary antibody (2° only) alone and little background fluorescence (No staining). |
PMC1266025_F4_3590.jpg | What stands out most in this visual? | Immunofluorescent staining of EphB4 in prostate cancer cell lines. Immunofluorescent staining of EphB4 in prostate cancer cell lines showing diffuse staining on the surface and in the cytoplasm of LNCaP and DU145 and in the cytoplasm only of PC3. There was no reactivity to the primary antibody (EphB4 1° only) or secondary antibody (2° only) alone and little background fluorescence (No staining). |
PMC1266025_F4_3591.jpg | Describe the main subject of this image. | Immunofluorescent staining of EphB4 in prostate cancer cell lines. Immunofluorescent staining of EphB4 in prostate cancer cell lines showing diffuse staining on the surface and in the cytoplasm of LNCaP and DU145 and in the cytoplasm only of PC3. There was no reactivity to the primary antibody (EphB4 1° only) or secondary antibody (2° only) alone and little background fluorescence (No staining). |
PMC1266025_F4_3596.jpg | What is the central feature of this picture? | Immunofluorescent staining of EphB4 in prostate cancer cell lines. Immunofluorescent staining of EphB4 in prostate cancer cell lines showing diffuse staining on the surface and in the cytoplasm of LNCaP and DU145 and in the cytoplasm only of PC3. There was no reactivity to the primary antibody (EphB4 1° only) or secondary antibody (2° only) alone and little background fluorescence (No staining). |
PMC1266025_F5_3621.jpg | What is the central feature of this picture? | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3626.jpg | What is shown in this image? | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3638.jpg | Describe the main subject of this image. | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3628.jpg | What is the central feature of this picture? | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3617.jpg | What key item or scene is captured in this photo? | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3631.jpg | What is the dominant medical problem in this image? | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3615.jpg | What is being portrayed in this visual content? | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3633.jpg | What is shown in this image? | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3630.jpg | What is the focal point of this photograph? | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3616.jpg | Describe the main subject of this image. | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3620.jpg | What object or scene is depicted here? | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3618.jpg | What is the dominant medical problem in this image? | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3625.jpg | What stands out most in this visual? | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3619.jpg | What is the dominant medical problem in this image? | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3637.jpg | Describe the main subject of this image. | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3623.jpg | What is the principal component of this image? | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3622.jpg | What's the most prominent thing you notice in this picture? | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F5_3624.jpg | What is the principal component of this image? | Immunohistochemical staining of EphB4 in prostate cancer samples. The expression of EphB4 in human prostate carcinomas was detected using immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples. Images (20× magnification) of normal (panel 2) and diseased tissue (panel 4) from eight different patient samples are shown with a Haematoxylin/eosin stained consecutive section (panels 1 and 3). The Gleason score for each disease focus is shown in the top left-hand corner of the image of each tumour focus. A single sample that contained a focus of basal cell hyperplasia, two samples with well-differentiated adenocarcinoma, two samples of moderately differentiated adenocarcinoma and three samples of poorly differentiated adenocarcinoma are shown. The brown stain from the biotinylated secondary antibody indicates the EphB4 protein. Nuclei are stained with Harris haematoxylin and appear blue. Staining of normal tissues was either absent or weak and diffuse. Increased staining of the tumour tissue appeared to correlate with increased Gleason score. There was no cross-reactivity with the secondary antibody alone (result not shown). |
PMC1266025_F6_3600.jpg | What does this image primarily show? | Immunohistochemical staining of EphB4 in several foci of a single prostate cancer sample. The expression of EphB4 a different foci in a single patient sample was compared by immunohistochemistry. Images from 10× magnification (A) and a region from this (as indicated by the box) at 20× magnification (B) are shown for 2 regions of normal prostate duct (1 and 2) and 8 regions with disease (3–10) from this single sample. A comparable level of EphB4 staining was seen in regions of high grade PIN (eg. focus 8 indicated PIN) and regions of poorly differentiated adenocarcinoma (eg. focus 7 indicated PDA). Regions of well-differentiated (eg focus 3) and moderately differentiated (eg focus 10) also show comparable staining. |
PMC1266025_F6_3602.jpg | What key item or scene is captured in this photo? | Immunohistochemical staining of EphB4 in several foci of a single prostate cancer sample. The expression of EphB4 a different foci in a single patient sample was compared by immunohistochemistry. Images from 10× magnification (A) and a region from this (as indicated by the box) at 20× magnification (B) are shown for 2 regions of normal prostate duct (1 and 2) and 8 regions with disease (3–10) from this single sample. A comparable level of EphB4 staining was seen in regions of high grade PIN (eg. focus 8 indicated PIN) and regions of poorly differentiated adenocarcinoma (eg. focus 7 indicated PDA). Regions of well-differentiated (eg focus 3) and moderately differentiated (eg focus 10) also show comparable staining. |
PMC1266025_F6_3609.jpg | What is the core subject represented in this visual? | Immunohistochemical staining of EphB4 in several foci of a single prostate cancer sample. The expression of EphB4 a different foci in a single patient sample was compared by immunohistochemistry. Images from 10× magnification (A) and a region from this (as indicated by the box) at 20× magnification (B) are shown for 2 regions of normal prostate duct (1 and 2) and 8 regions with disease (3–10) from this single sample. A comparable level of EphB4 staining was seen in regions of high grade PIN (eg. focus 8 indicated PIN) and regions of poorly differentiated adenocarcinoma (eg. focus 7 indicated PDA). Regions of well-differentiated (eg focus 3) and moderately differentiated (eg focus 10) also show comparable staining. |
PMC1266025_F6_3613.jpg | What is shown in this image? | Immunohistochemical staining of EphB4 in several foci of a single prostate cancer sample. The expression of EphB4 a different foci in a single patient sample was compared by immunohistochemistry. Images from 10× magnification (A) and a region from this (as indicated by the box) at 20× magnification (B) are shown for 2 regions of normal prostate duct (1 and 2) and 8 regions with disease (3–10) from this single sample. A comparable level of EphB4 staining was seen in regions of high grade PIN (eg. focus 8 indicated PIN) and regions of poorly differentiated adenocarcinoma (eg. focus 7 indicated PDA). Regions of well-differentiated (eg focus 3) and moderately differentiated (eg focus 10) also show comparable staining. |
PMC1266025_F6_3610.jpg | Describe the main subject of this image. | Immunohistochemical staining of EphB4 in several foci of a single prostate cancer sample. The expression of EphB4 a different foci in a single patient sample was compared by immunohistochemistry. Images from 10× magnification (A) and a region from this (as indicated by the box) at 20× magnification (B) are shown for 2 regions of normal prostate duct (1 and 2) and 8 regions with disease (3–10) from this single sample. A comparable level of EphB4 staining was seen in regions of high grade PIN (eg. focus 8 indicated PIN) and regions of poorly differentiated adenocarcinoma (eg. focus 7 indicated PDA). Regions of well-differentiated (eg focus 3) and moderately differentiated (eg focus 10) also show comparable staining. |
PMC1266025_F6_3605.jpg | What object or scene is depicted here? | Immunohistochemical staining of EphB4 in several foci of a single prostate cancer sample. The expression of EphB4 a different foci in a single patient sample was compared by immunohistochemistry. Images from 10× magnification (A) and a region from this (as indicated by the box) at 20× magnification (B) are shown for 2 regions of normal prostate duct (1 and 2) and 8 regions with disease (3–10) from this single sample. A comparable level of EphB4 staining was seen in regions of high grade PIN (eg. focus 8 indicated PIN) and regions of poorly differentiated adenocarcinoma (eg. focus 7 indicated PDA). Regions of well-differentiated (eg focus 3) and moderately differentiated (eg focus 10) also show comparable staining. |
PMC1266025_F6_3598.jpg | What is the focal point of this photograph? | Immunohistochemical staining of EphB4 in several foci of a single prostate cancer sample. The expression of EphB4 a different foci in a single patient sample was compared by immunohistochemistry. Images from 10× magnification (A) and a region from this (as indicated by the box) at 20× magnification (B) are shown for 2 regions of normal prostate duct (1 and 2) and 8 regions with disease (3–10) from this single sample. A comparable level of EphB4 staining was seen in regions of high grade PIN (eg. focus 8 indicated PIN) and regions of poorly differentiated adenocarcinoma (eg. focus 7 indicated PDA). Regions of well-differentiated (eg focus 3) and moderately differentiated (eg focus 10) also show comparable staining. |
PMC1266025_F6_3611.jpg | Describe the main subject of this image. | Immunohistochemical staining of EphB4 in several foci of a single prostate cancer sample. The expression of EphB4 a different foci in a single patient sample was compared by immunohistochemistry. Images from 10× magnification (A) and a region from this (as indicated by the box) at 20× magnification (B) are shown for 2 regions of normal prostate duct (1 and 2) and 8 regions with disease (3–10) from this single sample. A comparable level of EphB4 staining was seen in regions of high grade PIN (eg. focus 8 indicated PIN) and regions of poorly differentiated adenocarcinoma (eg. focus 7 indicated PDA). Regions of well-differentiated (eg focus 3) and moderately differentiated (eg focus 10) also show comparable staining. |
PMC1266025_F6_3612.jpg | What object or scene is depicted here? | Immunohistochemical staining of EphB4 in several foci of a single prostate cancer sample. The expression of EphB4 a different foci in a single patient sample was compared by immunohistochemistry. Images from 10× magnification (A) and a region from this (as indicated by the box) at 20× magnification (B) are shown for 2 regions of normal prostate duct (1 and 2) and 8 regions with disease (3–10) from this single sample. A comparable level of EphB4 staining was seen in regions of high grade PIN (eg. focus 8 indicated PIN) and regions of poorly differentiated adenocarcinoma (eg. focus 7 indicated PDA). Regions of well-differentiated (eg focus 3) and moderately differentiated (eg focus 10) also show comparable staining. |
PMC1266025_F6_3601.jpg | Can you identify the primary element in this image? | Immunohistochemical staining of EphB4 in several foci of a single prostate cancer sample. The expression of EphB4 a different foci in a single patient sample was compared by immunohistochemistry. Images from 10× magnification (A) and a region from this (as indicated by the box) at 20× magnification (B) are shown for 2 regions of normal prostate duct (1 and 2) and 8 regions with disease (3–10) from this single sample. A comparable level of EphB4 staining was seen in regions of high grade PIN (eg. focus 8 indicated PIN) and regions of poorly differentiated adenocarcinoma (eg. focus 7 indicated PDA). Regions of well-differentiated (eg focus 3) and moderately differentiated (eg focus 10) also show comparable staining. |
PMC1266025_F6_3608.jpg | What stands out most in this visual? | Immunohistochemical staining of EphB4 in several foci of a single prostate cancer sample. The expression of EphB4 a different foci in a single patient sample was compared by immunohistochemistry. Images from 10× magnification (A) and a region from this (as indicated by the box) at 20× magnification (B) are shown for 2 regions of normal prostate duct (1 and 2) and 8 regions with disease (3–10) from this single sample. A comparable level of EphB4 staining was seen in regions of high grade PIN (eg. focus 8 indicated PIN) and regions of poorly differentiated adenocarcinoma (eg. focus 7 indicated PDA). Regions of well-differentiated (eg focus 3) and moderately differentiated (eg focus 10) also show comparable staining. |
PMC1266025_F6_3603.jpg | What can you see in this picture? | Immunohistochemical staining of EphB4 in several foci of a single prostate cancer sample. The expression of EphB4 a different foci in a single patient sample was compared by immunohistochemistry. Images from 10× magnification (A) and a region from this (as indicated by the box) at 20× magnification (B) are shown for 2 regions of normal prostate duct (1 and 2) and 8 regions with disease (3–10) from this single sample. A comparable level of EphB4 staining was seen in regions of high grade PIN (eg. focus 8 indicated PIN) and regions of poorly differentiated adenocarcinoma (eg. focus 7 indicated PDA). Regions of well-differentiated (eg focus 3) and moderately differentiated (eg focus 10) also show comparable staining. |
PMC1266025_F6_3606.jpg | What's the most prominent thing you notice in this picture? | Immunohistochemical staining of EphB4 in several foci of a single prostate cancer sample. The expression of EphB4 a different foci in a single patient sample was compared by immunohistochemistry. Images from 10× magnification (A) and a region from this (as indicated by the box) at 20× magnification (B) are shown for 2 regions of normal prostate duct (1 and 2) and 8 regions with disease (3–10) from this single sample. A comparable level of EphB4 staining was seen in regions of high grade PIN (eg. focus 8 indicated PIN) and regions of poorly differentiated adenocarcinoma (eg. focus 7 indicated PDA). Regions of well-differentiated (eg focus 3) and moderately differentiated (eg focus 10) also show comparable staining. |
PMC1266025_F6_3604.jpg | What is being portrayed in this visual content? | Immunohistochemical staining of EphB4 in several foci of a single prostate cancer sample. The expression of EphB4 a different foci in a single patient sample was compared by immunohistochemistry. Images from 10× magnification (A) and a region from this (as indicated by the box) at 20× magnification (B) are shown for 2 regions of normal prostate duct (1 and 2) and 8 regions with disease (3–10) from this single sample. A comparable level of EphB4 staining was seen in regions of high grade PIN (eg. focus 8 indicated PIN) and regions of poorly differentiated adenocarcinoma (eg. focus 7 indicated PDA). Regions of well-differentiated (eg focus 3) and moderately differentiated (eg focus 10) also show comparable staining. |
PMC1266042_F1_3639.jpg | What is the central feature of this picture? | Panoramic radiograph before therapy. Unicystic radiolucent lesion in the lawer right jaw with a comparatively clear demarcation. The tooth 43 is located on the floor of this process. There are no resorption of the root apices. |
PMC1266042_F5_3640.jpg | What is shown in this image? | Panoramic radiograph six months after therapy. No root resorption could be observed. |
PMC1266044_F2_3642.jpg | What's the most prominent thing you notice in this picture? | Photomicrographs of the guinea pig trachea showing (a) all nerve fibers immunostained for the pan neuronal marker Protein Gene Product 9.5; (b) jugular ganglia derived chemosensitive C-fiber plexus immunostained for substance P and (c-f) four representative nodose ganglia-derived low threshold mechanosensors (putative cough receptors) stained using the Fluorescent Marker (FM) 2–10. Note the clear distinction between the terminal arrangements of airway C-fibers and cough receptors. The terminal structure of guinea pig SARs, RARs and Aδ-chemosensors is presently unknown. Magnification: X40 (a), X100 (b) and X200 (c-f). |
PMC1266044_F2_3641.jpg | What stands out most in this visual? | Photomicrographs of the guinea pig trachea showing (a) all nerve fibers immunostained for the pan neuronal marker Protein Gene Product 9.5; (b) jugular ganglia derived chemosensitive C-fiber plexus immunostained for substance P and (c-f) four representative nodose ganglia-derived low threshold mechanosensors (putative cough receptors) stained using the Fluorescent Marker (FM) 2–10. Note the clear distinction between the terminal arrangements of airway C-fibers and cough receptors. The terminal structure of guinea pig SARs, RARs and Aδ-chemosensors is presently unknown. Magnification: X40 (a), X100 (b) and X200 (c-f). |
PMC1266044_F2_3643.jpg | What object or scene is depicted here? | Photomicrographs of the guinea pig trachea showing (a) all nerve fibers immunostained for the pan neuronal marker Protein Gene Product 9.5; (b) jugular ganglia derived chemosensitive C-fiber plexus immunostained for substance P and (c-f) four representative nodose ganglia-derived low threshold mechanosensors (putative cough receptors) stained using the Fluorescent Marker (FM) 2–10. Note the clear distinction between the terminal arrangements of airway C-fibers and cough receptors. The terminal structure of guinea pig SARs, RARs and Aδ-chemosensors is presently unknown. Magnification: X40 (a), X100 (b) and X200 (c-f). |
PMC1266044_F2_3644.jpg | What can you see in this picture? | Photomicrographs of the guinea pig trachea showing (a) all nerve fibers immunostained for the pan neuronal marker Protein Gene Product 9.5; (b) jugular ganglia derived chemosensitive C-fiber plexus immunostained for substance P and (c-f) four representative nodose ganglia-derived low threshold mechanosensors (putative cough receptors) stained using the Fluorescent Marker (FM) 2–10. Note the clear distinction between the terminal arrangements of airway C-fibers and cough receptors. The terminal structure of guinea pig SARs, RARs and Aδ-chemosensors is presently unknown. Magnification: X40 (a), X100 (b) and X200 (c-f). |
PMC1266060_F3_3664.jpg | What does this image primarily show? | Dissemination of injected MLV vector producer cells from the injection site. Panels A, B, C and D are micrographs from brain sections of an animal injected with pREV-HW3 vector producer cells, while panels E, F, G and H are micrographs from brain sections of an animal injected with helper cells transfected with pREV-HW1. Panel B shows the region of A bordered by a black rectangle at greater magnification. PLAP histochemical staining shows cells in different sites including the 4th ventricle and its lateral recesses and in the perimedian sulcus (A, B and G, respectively) and trapped in the subarachnoid space, between the meninges on the surface of the brain parenchyma, particularly in the region of the basal artery (C, D and F). Similar distributions were obtained with vector producing cells (A, B, C and D) and helper cells transfected with pREV-HW1 (E, F, G and H). PMS, perimedian sulcus. Size bars indicate 200 μm (A and G), 100 μm (B), 125 μm (C and D), 450 μm (E), 360 μm (F) and 250 μm (H). |
PMC1266060_F3_3663.jpg | What can you see in this picture? | Dissemination of injected MLV vector producer cells from the injection site. Panels A, B, C and D are micrographs from brain sections of an animal injected with pREV-HW3 vector producer cells, while panels E, F, G and H are micrographs from brain sections of an animal injected with helper cells transfected with pREV-HW1. Panel B shows the region of A bordered by a black rectangle at greater magnification. PLAP histochemical staining shows cells in different sites including the 4th ventricle and its lateral recesses and in the perimedian sulcus (A, B and G, respectively) and trapped in the subarachnoid space, between the meninges on the surface of the brain parenchyma, particularly in the region of the basal artery (C, D and F). Similar distributions were obtained with vector producing cells (A, B, C and D) and helper cells transfected with pREV-HW1 (E, F, G and H). PMS, perimedian sulcus. Size bars indicate 200 μm (A and G), 100 μm (B), 125 μm (C and D), 450 μm (E), 360 μm (F) and 250 μm (H). |
PMC1266060_F3_3665.jpg | What is the central feature of this picture? | Dissemination of injected MLV vector producer cells from the injection site. Panels A, B, C and D are micrographs from brain sections of an animal injected with pREV-HW3 vector producer cells, while panels E, F, G and H are micrographs from brain sections of an animal injected with helper cells transfected with pREV-HW1. Panel B shows the region of A bordered by a black rectangle at greater magnification. PLAP histochemical staining shows cells in different sites including the 4th ventricle and its lateral recesses and in the perimedian sulcus (A, B and G, respectively) and trapped in the subarachnoid space, between the meninges on the surface of the brain parenchyma, particularly in the region of the basal artery (C, D and F). Similar distributions were obtained with vector producing cells (A, B, C and D) and helper cells transfected with pREV-HW1 (E, F, G and H). PMS, perimedian sulcus. Size bars indicate 200 μm (A and G), 100 μm (B), 125 μm (C and D), 450 μm (E), 360 μm (F) and 250 μm (H). |
PMC1266060_F3_3670.jpg | What stands out most in this visual? | Dissemination of injected MLV vector producer cells from the injection site. Panels A, B, C and D are micrographs from brain sections of an animal injected with pREV-HW3 vector producer cells, while panels E, F, G and H are micrographs from brain sections of an animal injected with helper cells transfected with pREV-HW1. Panel B shows the region of A bordered by a black rectangle at greater magnification. PLAP histochemical staining shows cells in different sites including the 4th ventricle and its lateral recesses and in the perimedian sulcus (A, B and G, respectively) and trapped in the subarachnoid space, between the meninges on the surface of the brain parenchyma, particularly in the region of the basal artery (C, D and F). Similar distributions were obtained with vector producing cells (A, B, C and D) and helper cells transfected with pREV-HW1 (E, F, G and H). PMS, perimedian sulcus. Size bars indicate 200 μm (A and G), 100 μm (B), 125 μm (C and D), 450 μm (E), 360 μm (F) and 250 μm (H). |
PMC1266060_F3_3666.jpg | What can you see in this picture? | Dissemination of injected MLV vector producer cells from the injection site. Panels A, B, C and D are micrographs from brain sections of an animal injected with pREV-HW3 vector producer cells, while panels E, F, G and H are micrographs from brain sections of an animal injected with helper cells transfected with pREV-HW1. Panel B shows the region of A bordered by a black rectangle at greater magnification. PLAP histochemical staining shows cells in different sites including the 4th ventricle and its lateral recesses and in the perimedian sulcus (A, B and G, respectively) and trapped in the subarachnoid space, between the meninges on the surface of the brain parenchyma, particularly in the region of the basal artery (C, D and F). Similar distributions were obtained with vector producing cells (A, B, C and D) and helper cells transfected with pREV-HW1 (E, F, G and H). PMS, perimedian sulcus. Size bars indicate 200 μm (A and G), 100 μm (B), 125 μm (C and D), 450 μm (E), 360 μm (F) and 250 μm (H). |
PMC1266060_F3_3672.jpg | Can you identify the primary element in this image? | Dissemination of injected MLV vector producer cells from the injection site. Panels A, B, C and D are micrographs from brain sections of an animal injected with pREV-HW3 vector producer cells, while panels E, F, G and H are micrographs from brain sections of an animal injected with helper cells transfected with pREV-HW1. Panel B shows the region of A bordered by a black rectangle at greater magnification. PLAP histochemical staining shows cells in different sites including the 4th ventricle and its lateral recesses and in the perimedian sulcus (A, B and G, respectively) and trapped in the subarachnoid space, between the meninges on the surface of the brain parenchyma, particularly in the region of the basal artery (C, D and F). Similar distributions were obtained with vector producing cells (A, B, C and D) and helper cells transfected with pREV-HW1 (E, F, G and H). PMS, perimedian sulcus. Size bars indicate 200 μm (A and G), 100 μm (B), 125 μm (C and D), 450 μm (E), 360 μm (F) and 250 μm (H). |
PMC1266060_F3_3669.jpg | What is the central feature of this picture? | Dissemination of injected MLV vector producer cells from the injection site. Panels A, B, C and D are micrographs from brain sections of an animal injected with pREV-HW3 vector producer cells, while panels E, F, G and H are micrographs from brain sections of an animal injected with helper cells transfected with pREV-HW1. Panel B shows the region of A bordered by a black rectangle at greater magnification. PLAP histochemical staining shows cells in different sites including the 4th ventricle and its lateral recesses and in the perimedian sulcus (A, B and G, respectively) and trapped in the subarachnoid space, between the meninges on the surface of the brain parenchyma, particularly in the region of the basal artery (C, D and F). Similar distributions were obtained with vector producing cells (A, B, C and D) and helper cells transfected with pREV-HW1 (E, F, G and H). PMS, perimedian sulcus. Size bars indicate 200 μm (A and G), 100 μm (B), 125 μm (C and D), 450 μm (E), 360 μm (F) and 250 μm (H). |
PMC1266060_F3_3668.jpg | What does this image primarily show? | Dissemination of injected MLV vector producer cells from the injection site. Panels A, B, C and D are micrographs from brain sections of an animal injected with pREV-HW3 vector producer cells, while panels E, F, G and H are micrographs from brain sections of an animal injected with helper cells transfected with pREV-HW1. Panel B shows the region of A bordered by a black rectangle at greater magnification. PLAP histochemical staining shows cells in different sites including the 4th ventricle and its lateral recesses and in the perimedian sulcus (A, B and G, respectively) and trapped in the subarachnoid space, between the meninges on the surface of the brain parenchyma, particularly in the region of the basal artery (C, D and F). Similar distributions were obtained with vector producing cells (A, B, C and D) and helper cells transfected with pREV-HW1 (E, F, G and H). PMS, perimedian sulcus. Size bars indicate 200 μm (A and G), 100 μm (B), 125 μm (C and D), 450 μm (E), 360 μm (F) and 250 μm (H). |
PMC1266060_F3_3667.jpg | What key item or scene is captured in this photo? | Dissemination of injected MLV vector producer cells from the injection site. Panels A, B, C and D are micrographs from brain sections of an animal injected with pREV-HW3 vector producer cells, while panels E, F, G and H are micrographs from brain sections of an animal injected with helper cells transfected with pREV-HW1. Panel B shows the region of A bordered by a black rectangle at greater magnification. PLAP histochemical staining shows cells in different sites including the 4th ventricle and its lateral recesses and in the perimedian sulcus (A, B and G, respectively) and trapped in the subarachnoid space, between the meninges on the surface of the brain parenchyma, particularly in the region of the basal artery (C, D and F). Similar distributions were obtained with vector producing cells (A, B, C and D) and helper cells transfected with pREV-HW1 (E, F, G and H). PMS, perimedian sulcus. Size bars indicate 200 μm (A and G), 100 μm (B), 125 μm (C and D), 450 μm (E), 360 μm (F) and 250 μm (H). |
PMC1266060_F4_3657.jpg | What is shown in this image? | In vivo transduction of cells using pREV-HW3 vector in the cerebellum. 4 days post injection, histochemical staining of PLAP in brain sections shows labeled cells in the region occupied by neural precursors in the external granular layer of the cerebellum, observed as discrete cells (A and B) or patches of staining (C). Panel B shows the region bordered by the black rectangle in A at higher magnification. 15 dpi histochemistry revealed transduced cells in patches and scattered about the parenchyma of the cerebellum (D, E and F). The majority of cells were found in the internal granular layer (E and F) but cells were also found in and astride bands of cerebellar white matter which is indicated by a black arrow (D). Discrete cells often exhibit a clearly neuronal morphology (F), the thin arrow indicates a cell with the morphology of a granular neuron, the arrow head indicates a cell with the morphological characteristics of a cerebellar golgi neuron. PCL, purkinje cell layer. Scale bars are 200 μm (A), 100 μm (B, C, D), and 40 μm (E, F) |
PMC1266060_F4_3658.jpg | What is the focal point of this photograph? | In vivo transduction of cells using pREV-HW3 vector in the cerebellum. 4 days post injection, histochemical staining of PLAP in brain sections shows labeled cells in the region occupied by neural precursors in the external granular layer of the cerebellum, observed as discrete cells (A and B) or patches of staining (C). Panel B shows the region bordered by the black rectangle in A at higher magnification. 15 dpi histochemistry revealed transduced cells in patches and scattered about the parenchyma of the cerebellum (D, E and F). The majority of cells were found in the internal granular layer (E and F) but cells were also found in and astride bands of cerebellar white matter which is indicated by a black arrow (D). Discrete cells often exhibit a clearly neuronal morphology (F), the thin arrow indicates a cell with the morphology of a granular neuron, the arrow head indicates a cell with the morphological characteristics of a cerebellar golgi neuron. PCL, purkinje cell layer. Scale bars are 200 μm (A), 100 μm (B, C, D), and 40 μm (E, F) |
PMC1266060_F4_3659.jpg | What's the most prominent thing you notice in this picture? | In vivo transduction of cells using pREV-HW3 vector in the cerebellum. 4 days post injection, histochemical staining of PLAP in brain sections shows labeled cells in the region occupied by neural precursors in the external granular layer of the cerebellum, observed as discrete cells (A and B) or patches of staining (C). Panel B shows the region bordered by the black rectangle in A at higher magnification. 15 dpi histochemistry revealed transduced cells in patches and scattered about the parenchyma of the cerebellum (D, E and F). The majority of cells were found in the internal granular layer (E and F) but cells were also found in and astride bands of cerebellar white matter which is indicated by a black arrow (D). Discrete cells often exhibit a clearly neuronal morphology (F), the thin arrow indicates a cell with the morphology of a granular neuron, the arrow head indicates a cell with the morphological characteristics of a cerebellar golgi neuron. PCL, purkinje cell layer. Scale bars are 200 μm (A), 100 μm (B, C, D), and 40 μm (E, F) |
PMC1266060_F4_3662.jpg | Can you identify the primary element in this image? | In vivo transduction of cells using pREV-HW3 vector in the cerebellum. 4 days post injection, histochemical staining of PLAP in brain sections shows labeled cells in the region occupied by neural precursors in the external granular layer of the cerebellum, observed as discrete cells (A and B) or patches of staining (C). Panel B shows the region bordered by the black rectangle in A at higher magnification. 15 dpi histochemistry revealed transduced cells in patches and scattered about the parenchyma of the cerebellum (D, E and F). The majority of cells were found in the internal granular layer (E and F) but cells were also found in and astride bands of cerebellar white matter which is indicated by a black arrow (D). Discrete cells often exhibit a clearly neuronal morphology (F), the thin arrow indicates a cell with the morphology of a granular neuron, the arrow head indicates a cell with the morphological characteristics of a cerebellar golgi neuron. PCL, purkinje cell layer. Scale bars are 200 μm (A), 100 μm (B, C, D), and 40 μm (E, F) |
PMC1266060_F4_3660.jpg | What can you see in this picture? | In vivo transduction of cells using pREV-HW3 vector in the cerebellum. 4 days post injection, histochemical staining of PLAP in brain sections shows labeled cells in the region occupied by neural precursors in the external granular layer of the cerebellum, observed as discrete cells (A and B) or patches of staining (C). Panel B shows the region bordered by the black rectangle in A at higher magnification. 15 dpi histochemistry revealed transduced cells in patches and scattered about the parenchyma of the cerebellum (D, E and F). The majority of cells were found in the internal granular layer (E and F) but cells were also found in and astride bands of cerebellar white matter which is indicated by a black arrow (D). Discrete cells often exhibit a clearly neuronal morphology (F), the thin arrow indicates a cell with the morphology of a granular neuron, the arrow head indicates a cell with the morphological characteristics of a cerebellar golgi neuron. PCL, purkinje cell layer. Scale bars are 200 μm (A), 100 μm (B, C, D), and 40 μm (E, F) |
PMC1266060_F5_3647.jpg | What stands out most in this visual? | In vivo transduction of neural cells. Immunohistochemical labeling for PLAP (A) and the neuron-specific HU antigen (B) was used to identify pREV-HW3 transduced neurons in the cerebellum (5 dpi). Examples of cells expressing both antigens are indicated by white arrows. Cells expressing PLAP were identified on the peripheral extremity of the section (magenta arrowhead in A, B and C). Transduced cells were also found in the brain parenchyma (example indicated by white arrowhead). In all the regions examined transduced cells co-expressed both proteins as illustrated by immunodetection of both PLAP (D) and Neo (E) in cells in the IGL of the cerebellum (14 dpi). Co-expression of both antigens, PLAP (G) and Neo (H), also occurred in cells in the ventricular region such as in the ependymal walls of the 3rd ventricle (G, H and I). DNA is stained with bis-benzimide (C, F and I). PCL, purkinje cell layer; IGL, internal granular layer. Scale bars correspond to 150 μm (C and F), 75 μm (I) |
PMC1266060_F5_3651.jpg | What does this image primarily show? | In vivo transduction of neural cells. Immunohistochemical labeling for PLAP (A) and the neuron-specific HU antigen (B) was used to identify pREV-HW3 transduced neurons in the cerebellum (5 dpi). Examples of cells expressing both antigens are indicated by white arrows. Cells expressing PLAP were identified on the peripheral extremity of the section (magenta arrowhead in A, B and C). Transduced cells were also found in the brain parenchyma (example indicated by white arrowhead). In all the regions examined transduced cells co-expressed both proteins as illustrated by immunodetection of both PLAP (D) and Neo (E) in cells in the IGL of the cerebellum (14 dpi). Co-expression of both antigens, PLAP (G) and Neo (H), also occurred in cells in the ventricular region such as in the ependymal walls of the 3rd ventricle (G, H and I). DNA is stained with bis-benzimide (C, F and I). PCL, purkinje cell layer; IGL, internal granular layer. Scale bars correspond to 150 μm (C and F), 75 μm (I) |
PMC1266060_F5_3653.jpg | What's the most prominent thing you notice in this picture? | In vivo transduction of neural cells. Immunohistochemical labeling for PLAP (A) and the neuron-specific HU antigen (B) was used to identify pREV-HW3 transduced neurons in the cerebellum (5 dpi). Examples of cells expressing both antigens are indicated by white arrows. Cells expressing PLAP were identified on the peripheral extremity of the section (magenta arrowhead in A, B and C). Transduced cells were also found in the brain parenchyma (example indicated by white arrowhead). In all the regions examined transduced cells co-expressed both proteins as illustrated by immunodetection of both PLAP (D) and Neo (E) in cells in the IGL of the cerebellum (14 dpi). Co-expression of both antigens, PLAP (G) and Neo (H), also occurred in cells in the ventricular region such as in the ependymal walls of the 3rd ventricle (G, H and I). DNA is stained with bis-benzimide (C, F and I). PCL, purkinje cell layer; IGL, internal granular layer. Scale bars correspond to 150 μm (C and F), 75 μm (I) |
PMC1266060_F5_3648.jpg | Can you identify the primary element in this image? | In vivo transduction of neural cells. Immunohistochemical labeling for PLAP (A) and the neuron-specific HU antigen (B) was used to identify pREV-HW3 transduced neurons in the cerebellum (5 dpi). Examples of cells expressing both antigens are indicated by white arrows. Cells expressing PLAP were identified on the peripheral extremity of the section (magenta arrowhead in A, B and C). Transduced cells were also found in the brain parenchyma (example indicated by white arrowhead). In all the regions examined transduced cells co-expressed both proteins as illustrated by immunodetection of both PLAP (D) and Neo (E) in cells in the IGL of the cerebellum (14 dpi). Co-expression of both antigens, PLAP (G) and Neo (H), also occurred in cells in the ventricular region such as in the ependymal walls of the 3rd ventricle (G, H and I). DNA is stained with bis-benzimide (C, F and I). PCL, purkinje cell layer; IGL, internal granular layer. Scale bars correspond to 150 μm (C and F), 75 μm (I) |
PMC1266060_F5_3650.jpg | What stands out most in this visual? | In vivo transduction of neural cells. Immunohistochemical labeling for PLAP (A) and the neuron-specific HU antigen (B) was used to identify pREV-HW3 transduced neurons in the cerebellum (5 dpi). Examples of cells expressing both antigens are indicated by white arrows. Cells expressing PLAP were identified on the peripheral extremity of the section (magenta arrowhead in A, B and C). Transduced cells were also found in the brain parenchyma (example indicated by white arrowhead). In all the regions examined transduced cells co-expressed both proteins as illustrated by immunodetection of both PLAP (D) and Neo (E) in cells in the IGL of the cerebellum (14 dpi). Co-expression of both antigens, PLAP (G) and Neo (H), also occurred in cells in the ventricular region such as in the ependymal walls of the 3rd ventricle (G, H and I). DNA is stained with bis-benzimide (C, F and I). PCL, purkinje cell layer; IGL, internal granular layer. Scale bars correspond to 150 μm (C and F), 75 μm (I) |
PMC1266060_F5_3655.jpg | What is the focal point of this photograph? | In vivo transduction of neural cells. Immunohistochemical labeling for PLAP (A) and the neuron-specific HU antigen (B) was used to identify pREV-HW3 transduced neurons in the cerebellum (5 dpi). Examples of cells expressing both antigens are indicated by white arrows. Cells expressing PLAP were identified on the peripheral extremity of the section (magenta arrowhead in A, B and C). Transduced cells were also found in the brain parenchyma (example indicated by white arrowhead). In all the regions examined transduced cells co-expressed both proteins as illustrated by immunodetection of both PLAP (D) and Neo (E) in cells in the IGL of the cerebellum (14 dpi). Co-expression of both antigens, PLAP (G) and Neo (H), also occurred in cells in the ventricular region such as in the ependymal walls of the 3rd ventricle (G, H and I). DNA is stained with bis-benzimide (C, F and I). PCL, purkinje cell layer; IGL, internal granular layer. Scale bars correspond to 150 μm (C and F), 75 μm (I) |
PMC1266060_F5_3652.jpg | What is the core subject represented in this visual? | In vivo transduction of neural cells. Immunohistochemical labeling for PLAP (A) and the neuron-specific HU antigen (B) was used to identify pREV-HW3 transduced neurons in the cerebellum (5 dpi). Examples of cells expressing both antigens are indicated by white arrows. Cells expressing PLAP were identified on the peripheral extremity of the section (magenta arrowhead in A, B and C). Transduced cells were also found in the brain parenchyma (example indicated by white arrowhead). In all the regions examined transduced cells co-expressed both proteins as illustrated by immunodetection of both PLAP (D) and Neo (E) in cells in the IGL of the cerebellum (14 dpi). Co-expression of both antigens, PLAP (G) and Neo (H), also occurred in cells in the ventricular region such as in the ependymal walls of the 3rd ventricle (G, H and I). DNA is stained with bis-benzimide (C, F and I). PCL, purkinje cell layer; IGL, internal granular layer. Scale bars correspond to 150 μm (C and F), 75 μm (I) |
PMC1266370_F1_3680.jpg | What can you see in this picture? | Microscopic image (100 ×) of Gram-stained vaginal smears illustrating the different categories of vaginal microflora described:. a, b: grade Ia, i.e. mainly Lactobacillus crispatus cell types, plump quite homogeneous lactobacilli. c, d: grade Ib, i.e. non-L. crispatus cell types, long or short, thin lactobacilli. e, f: grade Iab, i.e. containing mixtures of L. crispatus and non-L. crispatus cell types. g, h: grade I-like, i.e. irregular-shaped Gram positive rods. i, j: grade II, i.e. mixture of Lactobacillus cell types and bacterial vaginosis-associated bacteria (Gardnerella, Bacteroides-Prevotella and Mobiluncus cell types). k, l: grade III, i.e. bacterial vaginosis. |
PMC1266370_F1_3679.jpg | What key item or scene is captured in this photo? | Microscopic image (100 ×) of Gram-stained vaginal smears illustrating the different categories of vaginal microflora described:. a, b: grade Ia, i.e. mainly Lactobacillus crispatus cell types, plump quite homogeneous lactobacilli. c, d: grade Ib, i.e. non-L. crispatus cell types, long or short, thin lactobacilli. e, f: grade Iab, i.e. containing mixtures of L. crispatus and non-L. crispatus cell types. g, h: grade I-like, i.e. irregular-shaped Gram positive rods. i, j: grade II, i.e. mixture of Lactobacillus cell types and bacterial vaginosis-associated bacteria (Gardnerella, Bacteroides-Prevotella and Mobiluncus cell types). k, l: grade III, i.e. bacterial vaginosis. |
PMC1266370_F1_3678.jpg | What key item or scene is captured in this photo? | Microscopic image (100 ×) of Gram-stained vaginal smears illustrating the different categories of vaginal microflora described:. a, b: grade Ia, i.e. mainly Lactobacillus crispatus cell types, plump quite homogeneous lactobacilli. c, d: grade Ib, i.e. non-L. crispatus cell types, long or short, thin lactobacilli. e, f: grade Iab, i.e. containing mixtures of L. crispatus and non-L. crispatus cell types. g, h: grade I-like, i.e. irregular-shaped Gram positive rods. i, j: grade II, i.e. mixture of Lactobacillus cell types and bacterial vaginosis-associated bacteria (Gardnerella, Bacteroides-Prevotella and Mobiluncus cell types). k, l: grade III, i.e. bacterial vaginosis. |
PMC1266370_F1_3682.jpg | What stands out most in this visual? | Microscopic image (100 ×) of Gram-stained vaginal smears illustrating the different categories of vaginal microflora described:. a, b: grade Ia, i.e. mainly Lactobacillus crispatus cell types, plump quite homogeneous lactobacilli. c, d: grade Ib, i.e. non-L. crispatus cell types, long or short, thin lactobacilli. e, f: grade Iab, i.e. containing mixtures of L. crispatus and non-L. crispatus cell types. g, h: grade I-like, i.e. irregular-shaped Gram positive rods. i, j: grade II, i.e. mixture of Lactobacillus cell types and bacterial vaginosis-associated bacteria (Gardnerella, Bacteroides-Prevotella and Mobiluncus cell types). k, l: grade III, i.e. bacterial vaginosis. |
PMC1266370_F1_3681.jpg | What is shown in this image? | Microscopic image (100 ×) of Gram-stained vaginal smears illustrating the different categories of vaginal microflora described:. a, b: grade Ia, i.e. mainly Lactobacillus crispatus cell types, plump quite homogeneous lactobacilli. c, d: grade Ib, i.e. non-L. crispatus cell types, long or short, thin lactobacilli. e, f: grade Iab, i.e. containing mixtures of L. crispatus and non-L. crispatus cell types. g, h: grade I-like, i.e. irregular-shaped Gram positive rods. i, j: grade II, i.e. mixture of Lactobacillus cell types and bacterial vaginosis-associated bacteria (Gardnerella, Bacteroides-Prevotella and Mobiluncus cell types). k, l: grade III, i.e. bacterial vaginosis. |
PMC1266370_F1_3675.jpg | What does this image primarily show? | Microscopic image (100 ×) of Gram-stained vaginal smears illustrating the different categories of vaginal microflora described:. a, b: grade Ia, i.e. mainly Lactobacillus crispatus cell types, plump quite homogeneous lactobacilli. c, d: grade Ib, i.e. non-L. crispatus cell types, long or short, thin lactobacilli. e, f: grade Iab, i.e. containing mixtures of L. crispatus and non-L. crispatus cell types. g, h: grade I-like, i.e. irregular-shaped Gram positive rods. i, j: grade II, i.e. mixture of Lactobacillus cell types and bacterial vaginosis-associated bacteria (Gardnerella, Bacteroides-Prevotella and Mobiluncus cell types). k, l: grade III, i.e. bacterial vaginosis. |
PMC1266370_F1_3674.jpg | What is the central feature of this picture? | Microscopic image (100 ×) of Gram-stained vaginal smears illustrating the different categories of vaginal microflora described:. a, b: grade Ia, i.e. mainly Lactobacillus crispatus cell types, plump quite homogeneous lactobacilli. c, d: grade Ib, i.e. non-L. crispatus cell types, long or short, thin lactobacilli. e, f: grade Iab, i.e. containing mixtures of L. crispatus and non-L. crispatus cell types. g, h: grade I-like, i.e. irregular-shaped Gram positive rods. i, j: grade II, i.e. mixture of Lactobacillus cell types and bacterial vaginosis-associated bacteria (Gardnerella, Bacteroides-Prevotella and Mobiluncus cell types). k, l: grade III, i.e. bacterial vaginosis. |
PMC1266370_F1_3677.jpg | What does this image primarily show? | Microscopic image (100 ×) of Gram-stained vaginal smears illustrating the different categories of vaginal microflora described:. a, b: grade Ia, i.e. mainly Lactobacillus crispatus cell types, plump quite homogeneous lactobacilli. c, d: grade Ib, i.e. non-L. crispatus cell types, long or short, thin lactobacilli. e, f: grade Iab, i.e. containing mixtures of L. crispatus and non-L. crispatus cell types. g, h: grade I-like, i.e. irregular-shaped Gram positive rods. i, j: grade II, i.e. mixture of Lactobacillus cell types and bacterial vaginosis-associated bacteria (Gardnerella, Bacteroides-Prevotella and Mobiluncus cell types). k, l: grade III, i.e. bacterial vaginosis. |
PMC1266370_F1_3676.jpg | What's the most prominent thing you notice in this picture? | Microscopic image (100 ×) of Gram-stained vaginal smears illustrating the different categories of vaginal microflora described:. a, b: grade Ia, i.e. mainly Lactobacillus crispatus cell types, plump quite homogeneous lactobacilli. c, d: grade Ib, i.e. non-L. crispatus cell types, long or short, thin lactobacilli. e, f: grade Iab, i.e. containing mixtures of L. crispatus and non-L. crispatus cell types. g, h: grade I-like, i.e. irregular-shaped Gram positive rods. i, j: grade II, i.e. mixture of Lactobacillus cell types and bacterial vaginosis-associated bacteria (Gardnerella, Bacteroides-Prevotella and Mobiluncus cell types). k, l: grade III, i.e. bacterial vaginosis. |
PMC1266388_F10_3684.jpg | What is shown in this image? | Top: Original image. Bottom: Enhanced Image using proposed fuzzy inference. |
PMC1266388_F10_3685.jpg | What is the central feature of this picture? | Top: Original image. Bottom: Enhanced Image using proposed fuzzy inference. |
PMC1266388_F11_3686.jpg | Can you identify the primary element in this image? | The result of applying Canny edge detection on the enhanced image (Fig. 10). Solid line is the coarse estimation outline. |
PMC1266388_F13_3689.jpg | What is being portrayed in this visual content? | A low quality TRUS image and the result of automatic and manual boundaries shown on the original images. Solid lines are manually segmented images and dash lines are the result of proposed algorithm. |
PMC1266388_F13_3688.jpg | What can you see in this picture? | A low quality TRUS image and the result of automatic and manual boundaries shown on the original images. Solid lines are manually segmented images and dash lines are the result of proposed algorithm. |
PMC1266393_F1_3690.jpg | What is shown in this image? | Postoperative 7th day chest radiograph of a rabbit of BTX-A group. |
PMC1266393_F2_3691.jpg | What is the dominant medical problem in this image? | Postoperative 7th day chest radiograph of a rabbit of control group. |
PMC1266401_F1_3696.jpg | What does this image primarily show? | At patient admission, left coronary angiogram revealed thrombotic obstruction of left anterior descending artery (A). Large thrombus in the right auricle emerging through tricuspid valve within right ventricle (B) and apical thrombus complicating anterior aneurysm (C) detected by computer tomography scan, performed the next day. Large thrombus emerging from superiour vena cava and prolabing in the right auricle, evidenced by Trans-oesophagial echocardiography (D). Extensive thrombus emerging from superiour vena cava within right auricle, evidenced by magnetic resonance imaging (E). |
PMC1266401_F1_3692.jpg | What object or scene is depicted here? | At patient admission, left coronary angiogram revealed thrombotic obstruction of left anterior descending artery (A). Large thrombus in the right auricle emerging through tricuspid valve within right ventricle (B) and apical thrombus complicating anterior aneurysm (C) detected by computer tomography scan, performed the next day. Large thrombus emerging from superiour vena cava and prolabing in the right auricle, evidenced by Trans-oesophagial echocardiography (D). Extensive thrombus emerging from superiour vena cava within right auricle, evidenced by magnetic resonance imaging (E). |
PMC1266401_F1_3694.jpg | What is shown in this image? | At patient admission, left coronary angiogram revealed thrombotic obstruction of left anterior descending artery (A). Large thrombus in the right auricle emerging through tricuspid valve within right ventricle (B) and apical thrombus complicating anterior aneurysm (C) detected by computer tomography scan, performed the next day. Large thrombus emerging from superiour vena cava and prolabing in the right auricle, evidenced by Trans-oesophagial echocardiography (D). Extensive thrombus emerging from superiour vena cava within right auricle, evidenced by magnetic resonance imaging (E). |
PMC1266401_F1_3695.jpg | What is the principal component of this image? | At patient admission, left coronary angiogram revealed thrombotic obstruction of left anterior descending artery (A). Large thrombus in the right auricle emerging through tricuspid valve within right ventricle (B) and apical thrombus complicating anterior aneurysm (C) detected by computer tomography scan, performed the next day. Large thrombus emerging from superiour vena cava and prolabing in the right auricle, evidenced by Trans-oesophagial echocardiography (D). Extensive thrombus emerging from superiour vena cava within right auricle, evidenced by magnetic resonance imaging (E). |
PMC1274244_F1_3697.jpg | What is being portrayed in this visual content? | Middle cerebral artery aneurysm angiogram, anteroposterior view. ACA Anterior Cerebral Artery, ICA Internal Carotid Artery, MCA Middle Cerebral Artery. Aneurysm is seen in the trifurcation of MCA |
PMC1274246_F6_3698.jpg | What is the core subject represented in this visual? | Effects of MPA on the yeast cell wall. A. Percentage of unbudded (shadow bars), single budded (white bars) and of cells with two buds (grey bars) after 4 hours treatment with 100 μg/mL MPA followed by a mild digestion of the cell wall with zymolyase. More than 200 cells were counted for each condition. B. Electron microscopy pictures of cells with two buds obtained after 4 hours treatment with 100 μg/mL MPA. Untreated control cells are shown on the right panel each steps of the septum formation are illustrated (from top to bottom). |
PMC1274246_F6_3700.jpg | Can you identify the primary element in this image? | Effects of MPA on the yeast cell wall. A. Percentage of unbudded (shadow bars), single budded (white bars) and of cells with two buds (grey bars) after 4 hours treatment with 100 μg/mL MPA followed by a mild digestion of the cell wall with zymolyase. More than 200 cells were counted for each condition. B. Electron microscopy pictures of cells with two buds obtained after 4 hours treatment with 100 μg/mL MPA. Untreated control cells are shown on the right panel each steps of the septum formation are illustrated (from top to bottom). |
PMC1274303_F3_3701.jpg | What is the focal point of this photograph? | Biopsy of gastric mucosa showing inflammation (gastritis) from several SIR spheres, clearly visible. |
PMC1274328_F1_3702.jpg | What's the most prominent thing you notice in this picture? | Sonography of screws. Two distal locking screws can be visualized by sonography. The image of two extremely brightness with "comet-tails" indicate the distal locking screw heads. |
PMC1274329_F1_3703.jpg | What is the core subject represented in this visual? | 99mTc-MIBI placebo tablet scintigraphic image 2 hours after drug intake for one volunteer. |
PMC1274329_F2_3705.jpg | Can you identify the primary element in this image? | Scintigraphic image 2 hours after drug intake for one volunteer 99mTc-ECD placebo tablets. |
PMC1274329_F3_3704.jpg | What can you see in this picture? | Scintigraphic image 2 hours after drug intake for one 99mTc-MDP placebo tablets in one volunteer. |
PMC1274334_F4_3715.jpg | Can you identify the primary element in this image? | Callose content of cals5 pollen tubes. Aniline blue staining (a-h,j,l,n,p) and differential interference contrast optics (i,k,m,o) of sections of tetrad stage anthers (a-d), self-pollinated pistils (e-h), pollen tubes germinated on an excised stigma and elongating in vitro (i-l), in vitro germinated pollen tubes; arrowheads, callose plugs (m-p). Wild-type (a,e,i,j,m,n), cals5-3 (b,f,k,l,o,p), cals5-4 (c,g), and cals5-5 (d,h). Wild type (upper) and cals5-3 (lower) pollen tubes stained with anti-β-1,3 glucan primary and FITC secondary antibodies (q), cellulose staining with calcofluor white (r), and pectin staining with Alcian blue 8GX (s). Bars, 10 μm (a-d, m-s); 100 μm (e-l). |
PMC1274334_F4_3711.jpg | What is shown in this image? | Callose content of cals5 pollen tubes. Aniline blue staining (a-h,j,l,n,p) and differential interference contrast optics (i,k,m,o) of sections of tetrad stage anthers (a-d), self-pollinated pistils (e-h), pollen tubes germinated on an excised stigma and elongating in vitro (i-l), in vitro germinated pollen tubes; arrowheads, callose plugs (m-p). Wild-type (a,e,i,j,m,n), cals5-3 (b,f,k,l,o,p), cals5-4 (c,g), and cals5-5 (d,h). Wild type (upper) and cals5-3 (lower) pollen tubes stained with anti-β-1,3 glucan primary and FITC secondary antibodies (q), cellulose staining with calcofluor white (r), and pectin staining with Alcian blue 8GX (s). Bars, 10 μm (a-d, m-s); 100 μm (e-l). |
PMC1274334_F4_3713.jpg | What is being portrayed in this visual content? | Callose content of cals5 pollen tubes. Aniline blue staining (a-h,j,l,n,p) and differential interference contrast optics (i,k,m,o) of sections of tetrad stage anthers (a-d), self-pollinated pistils (e-h), pollen tubes germinated on an excised stigma and elongating in vitro (i-l), in vitro germinated pollen tubes; arrowheads, callose plugs (m-p). Wild-type (a,e,i,j,m,n), cals5-3 (b,f,k,l,o,p), cals5-4 (c,g), and cals5-5 (d,h). Wild type (upper) and cals5-3 (lower) pollen tubes stained with anti-β-1,3 glucan primary and FITC secondary antibodies (q), cellulose staining with calcofluor white (r), and pectin staining with Alcian blue 8GX (s). Bars, 10 μm (a-d, m-s); 100 μm (e-l). |
PMC1274334_F4_3716.jpg | What is the main focus of this visual representation? | Callose content of cals5 pollen tubes. Aniline blue staining (a-h,j,l,n,p) and differential interference contrast optics (i,k,m,o) of sections of tetrad stage anthers (a-d), self-pollinated pistils (e-h), pollen tubes germinated on an excised stigma and elongating in vitro (i-l), in vitro germinated pollen tubes; arrowheads, callose plugs (m-p). Wild-type (a,e,i,j,m,n), cals5-3 (b,f,k,l,o,p), cals5-4 (c,g), and cals5-5 (d,h). Wild type (upper) and cals5-3 (lower) pollen tubes stained with anti-β-1,3 glucan primary and FITC secondary antibodies (q), cellulose staining with calcofluor white (r), and pectin staining with Alcian blue 8GX (s). Bars, 10 μm (a-d, m-s); 100 μm (e-l). |
PMC1274334_F4_3710.jpg | Describe the main subject of this image. | Callose content of cals5 pollen tubes. Aniline blue staining (a-h,j,l,n,p) and differential interference contrast optics (i,k,m,o) of sections of tetrad stage anthers (a-d), self-pollinated pistils (e-h), pollen tubes germinated on an excised stigma and elongating in vitro (i-l), in vitro germinated pollen tubes; arrowheads, callose plugs (m-p). Wild-type (a,e,i,j,m,n), cals5-3 (b,f,k,l,o,p), cals5-4 (c,g), and cals5-5 (d,h). Wild type (upper) and cals5-3 (lower) pollen tubes stained with anti-β-1,3 glucan primary and FITC secondary antibodies (q), cellulose staining with calcofluor white (r), and pectin staining with Alcian blue 8GX (s). Bars, 10 μm (a-d, m-s); 100 μm (e-l). |
PMC1274334_F4_3718.jpg | What does this image primarily show? | Callose content of cals5 pollen tubes. Aniline blue staining (a-h,j,l,n,p) and differential interference contrast optics (i,k,m,o) of sections of tetrad stage anthers (a-d), self-pollinated pistils (e-h), pollen tubes germinated on an excised stigma and elongating in vitro (i-l), in vitro germinated pollen tubes; arrowheads, callose plugs (m-p). Wild-type (a,e,i,j,m,n), cals5-3 (b,f,k,l,o,p), cals5-4 (c,g), and cals5-5 (d,h). Wild type (upper) and cals5-3 (lower) pollen tubes stained with anti-β-1,3 glucan primary and FITC secondary antibodies (q), cellulose staining with calcofluor white (r), and pectin staining with Alcian blue 8GX (s). Bars, 10 μm (a-d, m-s); 100 μm (e-l). |
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