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PMC1402295_F2_4844.jpg | What is the dominant medical problem in this image? | Regions of interest. Regions of interest (ROI) of typical ultrasound images of m. supraspinatus (upper left) and m. vastus lateralis (upper right). Binary images at three different thresholds (T). T = 33, (second from the top), T = 53 (second from the bottom) and T = 98 (at the bottom). |
PMC1402295_F2_4845.jpg | What does this image primarily show? | Regions of interest. Regions of interest (ROI) of typical ultrasound images of m. supraspinatus (upper left) and m. vastus lateralis (upper right). Binary images at three different thresholds (T). T = 33, (second from the top), T = 53 (second from the bottom) and T = 98 (at the bottom). |
PMC1402309_F8_4847.jpg | What object or scene is depicted here? | Spectral confocal microscopy of metastatic melanoma cells stained with E8 scFv antibody. |
PMC1402317_F5_4850.jpg | What is the central feature of this picture? | Light micrograph of lung tissue from a rat exposed to R-100 TiO2 particles (5 mgs/kg) at 1 day post-instillation exposure. This micrograph illustrates the terminal bronchiole (TB) and corresponding alveolar ducts (AD), and demonstrates normal lung architecture and normal macrophage phagocytosis of R-100 particles (arrows). Magnification = ×100. |
PMC1402317_F5_4848.jpg | What is the main focus of this visual representation? | Light micrograph of lung tissue from a rat exposed to R-100 TiO2 particles (5 mgs/kg) at 1 day post-instillation exposure. This micrograph illustrates the terminal bronchiole (TB) and corresponding alveolar ducts (AD), and demonstrates normal lung architecture and normal macrophage phagocytosis of R-100 particles (arrows). Magnification = ×100. |
PMC1402317_F5_4851.jpg | What does this image primarily show? | Light micrograph of lung tissue from a rat exposed to R-100 TiO2 particles (5 mgs/kg) at 1 day post-instillation exposure. This micrograph illustrates the terminal bronchiole (TB) and corresponding alveolar ducts (AD), and demonstrates normal lung architecture and normal macrophage phagocytosis of R-100 particles (arrows). Magnification = ×100. |
PMC1402317_F6_4854.jpg | What is being portrayed in this visual content? | Light micrograph of lung tissue of a rat exposed to Pigment A TiO2 particles (5 mg/kg) at 3 months post-instillation exposure. This micrograph illustrates the terminal bronchiole (TB) and corresponding alveolar ducts (AD), and demonstrates normal lung architecture, indicating that exposure to Pigment A TiO2 particles produced no adverse pulmonary effects. Magnification = ×100. |
PMC1402317_F6_4855.jpg | What is the dominant medical problem in this image? | Light micrograph of lung tissue of a rat exposed to Pigment A TiO2 particles (5 mg/kg) at 3 months post-instillation exposure. This micrograph illustrates the terminal bronchiole (TB) and corresponding alveolar ducts (AD), and demonstrates normal lung architecture, indicating that exposure to Pigment A TiO2 particles produced no adverse pulmonary effects. Magnification = ×100. |
PMC1402317_F7_4858.jpg | Describe the main subject of this image. | Light micrograph of lung tissue from a rat exposed to quartz particles (5 mg/kg) at 1 month post-instillation exposure. This micrograph illustrates the terminal bronchiole (TB) and corresponding alveolar ducts (AD). Note the prominence of tissue thickening (arrows) at the junction at the terminal bronchiole and alveolar duct bifurcation. Magnification = ×100. |
PMC1402317_F7_4857.jpg | What key item or scene is captured in this photo? | Light micrograph of lung tissue from a rat exposed to quartz particles (5 mg/kg) at 1 month post-instillation exposure. This micrograph illustrates the terminal bronchiole (TB) and corresponding alveolar ducts (AD). Note the prominence of tissue thickening (arrows) at the junction at the terminal bronchiole and alveolar duct bifurcation. Magnification = ×100. |
PMC1402317_F8_4852.jpg | What stands out most in this visual? | Light micrograph of lung tissue from a rat exposed to quartz particles (5 mg/kg) at 3 months post-instillation exposure. Note the tissue accumulation of foamy multinucleated alveolar macrophages (arrows) within alveolar spaces. The macrophages have migrated to the sites of quartz particle deposition at the terminal bronchiolar alveolar junctions. The accumulation of lipid-filled macrophages and lack of clearance is a common feature of the progressive nature of silica induced lung disease. Magnification = ×100. |
PMC1402317_F8_4853.jpg | What's the most prominent thing you notice in this picture? | Light micrograph of lung tissue from a rat exposed to quartz particles (5 mg/kg) at 3 months post-instillation exposure. Note the tissue accumulation of foamy multinucleated alveolar macrophages (arrows) within alveolar spaces. The macrophages have migrated to the sites of quartz particle deposition at the terminal bronchiolar alveolar junctions. The accumulation of lipid-filled macrophages and lack of clearance is a common feature of the progressive nature of silica induced lung disease. Magnification = ×100. |
PMC1402319_F1_4860.jpg | Can you identify the primary element in this image? | Aspirate from the EUS-FNA of lymph node revealed small to intermediate sized mononuclear cells with moderate cytoplasm, round to oval nuclei with smooth nuclear borders, a stippled chromatin pattern and occasional single nucleoli. The cytoplasm is pale grey with hair-like and short, blunt, cytoplasmic projections. (Stain: Diff Quik, Magnification: × 40). |
PMC1402319_F1_4859.jpg | What object or scene is depicted here? | Aspirate from the EUS-FNA of lymph node revealed small to intermediate sized mononuclear cells with moderate cytoplasm, round to oval nuclei with smooth nuclear borders, a stippled chromatin pattern and occasional single nucleoli. The cytoplasm is pale grey with hair-like and short, blunt, cytoplasmic projections. (Stain: Diff Quik, Magnification: × 40). |
PMC1402319_F2_4861.jpg | What's the most prominent thing you notice in this picture? | A higher magnification of the aspirate from same area as shown in Figure 1 shows small to intermediate sized mononuclear cells with moderate cytoplasm, round to oval nuclei with smooth nuclear borders, a stippled chromatin pattern and occasional single nucleoli. The cytoplasm is pale grey and granular with hair-like and short, blunt, cytoplasmic projections. (Stain: Diff Quik, Magnification: × 60). |
PMC1403776_F1_4863.jpg | What is shown in this image? | Computed tomography (CT) of the abdomen demonstrating hepatomegaly and a large hypodense lesion of the liver with multicystic appearance with septations and solid portions. |
PMC1403776_F2_4864.jpg | What is the central feature of this picture? | Magnetic Resonance Imaging (MRI) in T2-weighted and Short Time Inversion Recovery (STIR) sequences revealing hyperdense areas with intermixed hypodense septa. |
PMC1403776_F3_4865.jpg | What object or scene is depicted here? | MRI revealing a thrombus in the inferior vena cava (the arrow shows the thrombus)]. |
PMC1403785_F5_4868.jpg | Can you identify the primary element in this image? | Surface expression of TV44 on trichomonads decreases after contact with VECs. FITC-conjugated goat anti-IgA antibody bound to IgA mAb 6B8 on the surface of non permeabilized T. vaginalis organisms as evident by uniform fluorescence seen in panel B1. In contrast, parasites isolated after contact with MS-74 VECs and handled identically had little or no detectable fluorescence as seen in panel B2. Brightfield pictures show the integrity of parasites used for the assay. No fluorescence was detectable in the absence of the mAb 6B8 as negative controls (not shown). |
PMC1403785_F5_4866.jpg | Can you identify the primary element in this image? | Surface expression of TV44 on trichomonads decreases after contact with VECs. FITC-conjugated goat anti-IgA antibody bound to IgA mAb 6B8 on the surface of non permeabilized T. vaginalis organisms as evident by uniform fluorescence seen in panel B1. In contrast, parasites isolated after contact with MS-74 VECs and handled identically had little or no detectable fluorescence as seen in panel B2. Brightfield pictures show the integrity of parasites used for the assay. No fluorescence was detectable in the absence of the mAb 6B8 as negative controls (not shown). |
PMC1403785_F5_4869.jpg | What is the principal component of this image? | Surface expression of TV44 on trichomonads decreases after contact with VECs. FITC-conjugated goat anti-IgA antibody bound to IgA mAb 6B8 on the surface of non permeabilized T. vaginalis organisms as evident by uniform fluorescence seen in panel B1. In contrast, parasites isolated after contact with MS-74 VECs and handled identically had little or no detectable fluorescence as seen in panel B2. Brightfield pictures show the integrity of parasites used for the assay. No fluorescence was detectable in the absence of the mAb 6B8 as negative controls (not shown). |
PMC1403785_F5_4867.jpg | Describe the main subject of this image. | Surface expression of TV44 on trichomonads decreases after contact with VECs. FITC-conjugated goat anti-IgA antibody bound to IgA mAb 6B8 on the surface of non permeabilized T. vaginalis organisms as evident by uniform fluorescence seen in panel B1. In contrast, parasites isolated after contact with MS-74 VECs and handled identically had little or no detectable fluorescence as seen in panel B2. Brightfield pictures show the integrity of parasites used for the assay. No fluorescence was detectable in the absence of the mAb 6B8 as negative controls (not shown). |
PMC1403788_F3_4870.jpg | What's the most prominent thing you notice in this picture? | CT scan showing a prostatic deposit of tumour metastases prior to chemotherapy. |
PMC1403788_F4_4871.jpg | What is the central feature of this picture? | CT scan showing a mesenteric deposit of tumour metastases prior to chemotherapy with no apparent para aortic lymph node enlargement. |
PMC1403788_F6_4873.jpg | Can you identify the primary element in this image? | CT scan showing complete regression of mesenteric metastases after chemotherapy. |
PMC1403789_F2_4881.jpg | What is the principal component of this image? | Microglial responses to LPS application. Coronal sections of motor cortex, immunoreacted with OX42 antibody to visualise microglia/macrophages 3 days (Figs 2a, b), 7 days (Figs 2c, d) and 2 weeks (Figs 2e, f) after unilateral application of LPS to the pial surface (Figs 2b, d, f) or sham operations on the contralateral (contra), control side (Figs 2a, c, e). Here and in all other figures, the pial surface is at the top and all sections are photographed immediately below the craniotomy, with the same exposure for all pairs of images taken at each survival time. Microglia from layer V are illustrated at higher magnification in the insets. Note that microglia are present throughout the full depth of cortex at all time points and are ramified in the control but are rounded and amoeboid and more numerous in the LPS-treated cortical tissue 3 days and 7 days after LPS application. The numerous immunoreactive cells at the pial surface on both sides of the brain (Figs 2a, b) are likely to be macrophages of haematogenous origin induced by local damage due to craniotomy. Note the reduction in number of such cells at 7 days and that very few remain at two weeks. Scale bar in Fig. 2a = 200 μm and also applies to Fig. 2b; scale bar in Fig. 2c = 200 μm and also applies to Figs 2d – f (Figs 2a and b are of greater magnification than Figs. 2c – f); scale bar in the inset to Fig. 2a = 50 μm and applies to all insets. |
PMC1403789_F2_4876.jpg | What is being portrayed in this visual content? | Microglial responses to LPS application. Coronal sections of motor cortex, immunoreacted with OX42 antibody to visualise microglia/macrophages 3 days (Figs 2a, b), 7 days (Figs 2c, d) and 2 weeks (Figs 2e, f) after unilateral application of LPS to the pial surface (Figs 2b, d, f) or sham operations on the contralateral (contra), control side (Figs 2a, c, e). Here and in all other figures, the pial surface is at the top and all sections are photographed immediately below the craniotomy, with the same exposure for all pairs of images taken at each survival time. Microglia from layer V are illustrated at higher magnification in the insets. Note that microglia are present throughout the full depth of cortex at all time points and are ramified in the control but are rounded and amoeboid and more numerous in the LPS-treated cortical tissue 3 days and 7 days after LPS application. The numerous immunoreactive cells at the pial surface on both sides of the brain (Figs 2a, b) are likely to be macrophages of haematogenous origin induced by local damage due to craniotomy. Note the reduction in number of such cells at 7 days and that very few remain at two weeks. Scale bar in Fig. 2a = 200 μm and also applies to Fig. 2b; scale bar in Fig. 2c = 200 μm and also applies to Figs 2d – f (Figs 2a and b are of greater magnification than Figs. 2c – f); scale bar in the inset to Fig. 2a = 50 μm and applies to all insets. |
PMC1403789_F2_4877.jpg | What is being portrayed in this visual content? | Microglial responses to LPS application. Coronal sections of motor cortex, immunoreacted with OX42 antibody to visualise microglia/macrophages 3 days (Figs 2a, b), 7 days (Figs 2c, d) and 2 weeks (Figs 2e, f) after unilateral application of LPS to the pial surface (Figs 2b, d, f) or sham operations on the contralateral (contra), control side (Figs 2a, c, e). Here and in all other figures, the pial surface is at the top and all sections are photographed immediately below the craniotomy, with the same exposure for all pairs of images taken at each survival time. Microglia from layer V are illustrated at higher magnification in the insets. Note that microglia are present throughout the full depth of cortex at all time points and are ramified in the control but are rounded and amoeboid and more numerous in the LPS-treated cortical tissue 3 days and 7 days after LPS application. The numerous immunoreactive cells at the pial surface on both sides of the brain (Figs 2a, b) are likely to be macrophages of haematogenous origin induced by local damage due to craniotomy. Note the reduction in number of such cells at 7 days and that very few remain at two weeks. Scale bar in Fig. 2a = 200 μm and also applies to Fig. 2b; scale bar in Fig. 2c = 200 μm and also applies to Figs 2d – f (Figs 2a and b are of greater magnification than Figs. 2c – f); scale bar in the inset to Fig. 2a = 50 μm and applies to all insets. |
PMC1403789_F2_4880.jpg | What is the focal point of this photograph? | Microglial responses to LPS application. Coronal sections of motor cortex, immunoreacted with OX42 antibody to visualise microglia/macrophages 3 days (Figs 2a, b), 7 days (Figs 2c, d) and 2 weeks (Figs 2e, f) after unilateral application of LPS to the pial surface (Figs 2b, d, f) or sham operations on the contralateral (contra), control side (Figs 2a, c, e). Here and in all other figures, the pial surface is at the top and all sections are photographed immediately below the craniotomy, with the same exposure for all pairs of images taken at each survival time. Microglia from layer V are illustrated at higher magnification in the insets. Note that microglia are present throughout the full depth of cortex at all time points and are ramified in the control but are rounded and amoeboid and more numerous in the LPS-treated cortical tissue 3 days and 7 days after LPS application. The numerous immunoreactive cells at the pial surface on both sides of the brain (Figs 2a, b) are likely to be macrophages of haematogenous origin induced by local damage due to craniotomy. Note the reduction in number of such cells at 7 days and that very few remain at two weeks. Scale bar in Fig. 2a = 200 μm and also applies to Fig. 2b; scale bar in Fig. 2c = 200 μm and also applies to Figs 2d – f (Figs 2a and b are of greater magnification than Figs. 2c – f); scale bar in the inset to Fig. 2a = 50 μm and applies to all insets. |
PMC1403789_F8_4874.jpg | What is being portrayed in this visual content? | Co-localisation of retrograde label and c-Jun or SCG10. CTB (red) in the cell bodies of CST neurons co-localised with c-Jun (Fig. 8a) or SCG10 (Fig. 8b) (green) in coronal sections of the motor cortex (layer V), 3 days after application of LPS and simultaneous injection of CTB into the CST at C4. Note that not all layer V neurons expressing c-Jun in their nuclei also show co-localisation with CTB (Fig. 8a). There is a higher degree of co-localisation between SCG10 and CTB (Fig. 8b). Confocal microscopy; scale bar = 20 μm and applies to both images. |
PMC1403789_F8_4875.jpg | Describe the main subject of this image. | Co-localisation of retrograde label and c-Jun or SCG10. CTB (red) in the cell bodies of CST neurons co-localised with c-Jun (Fig. 8a) or SCG10 (Fig. 8b) (green) in coronal sections of the motor cortex (layer V), 3 days after application of LPS and simultaneous injection of CTB into the CST at C4. Note that not all layer V neurons expressing c-Jun in their nuclei also show co-localisation with CTB (Fig. 8a). There is a higher degree of co-localisation between SCG10 and CTB (Fig. 8b). Confocal microscopy; scale bar = 20 μm and applies to both images. |
PMC1405738_F1_4885.jpg | Can you identify the primary element in this image? | A photograph of the crystal trophy presented to Dr. Stephen P. Goff, winner of the 2005 M. Jeang Retrovirology Prize. |
PMC1408080_F1_4887.jpg | Can you identify the primary element in this image? | Photograph of a symbiotic (left) and aposymbiotic (right) Anthopleura elegantissima. |
PMC1408080_F1_4886.jpg | What key item or scene is captured in this photo? | Photograph of a symbiotic (left) and aposymbiotic (right) Anthopleura elegantissima. |
PMC1409773_F2_4888.jpg | What stands out most in this visual? | Intraoperatively confirmed loosening of the proximal and distal components. An infection with coagulase negative staphylococcus was also identified. PET was initially interpreted as synovialitis without signs of mechanical loosening. The inflamed synovium as well as the periprosthetic osteolytic areas (arrow) filled with bacteria-infected granulation tissue showed 18F-FDG uptake. |
PMC1409773_F2_4891.jpg | What is being portrayed in this visual content? | Intraoperatively confirmed loosening of the proximal and distal components. An infection with coagulase negative staphylococcus was also identified. PET was initially interpreted as synovialitis without signs of mechanical loosening. The inflamed synovium as well as the periprosthetic osteolytic areas (arrow) filled with bacteria-infected granulation tissue showed 18F-FDG uptake. |
PMC1409773_F2_4889.jpg | Describe the main subject of this image. | Intraoperatively confirmed loosening of the proximal and distal components. An infection with coagulase negative staphylococcus was also identified. PET was initially interpreted as synovialitis without signs of mechanical loosening. The inflamed synovium as well as the periprosthetic osteolytic areas (arrow) filled with bacteria-infected granulation tissue showed 18F-FDG uptake. |
PMC1409773_F2_4890.jpg | What key item or scene is captured in this photo? | Intraoperatively confirmed loosening of the proximal and distal components. An infection with coagulase negative staphylococcus was also identified. PET was initially interpreted as synovialitis without signs of mechanical loosening. The inflamed synovium as well as the periprosthetic osteolytic areas (arrow) filled with bacteria-infected granulation tissue showed 18F-FDG uptake. |
PMC1409773_F5_4893.jpg | What is being portrayed in this visual content? | In a case with extensive abrasion-induced inflammation on the right hip prosthesis (bacterial infection was excluded) whereas bone scan in comparison to 18F-FDG-PET does not adequately demonstrate the pathology. The PET examination shows broad periprosthetic uptake as expression of synovitis. |
PMC1409773_F5_4892.jpg | What stands out most in this visual? | In a case with extensive abrasion-induced inflammation on the right hip prosthesis (bacterial infection was excluded) whereas bone scan in comparison to 18F-FDG-PET does not adequately demonstrate the pathology. The PET examination shows broad periprosthetic uptake as expression of synovitis. |
PMC1409812_pcbi-0020022-g004_4898.jpg | What is the main focus of this visual representation? | Examples of the Relationship of Projection Density to Axonal Trajectory(A) Low-power brightfield photomicrograph of a coronal section through the posterior prefrontal cortex of a rhesus monkey brain, showing the halo of an injection of HRP-WGA in ventral area 46, below the principal sulcus (dark area). Green arrows point to a projection site in area 46 in the depths of the lower bank of the principal sulcus (dark blotch). Another projection is found in the upper bank of the lower limb of the arcuate (“A”) sulcus (dark blotch, red arrow); axons from these projection sites can take a mildly deflected or straight course to the injection site.(B) Top: higher magnification under darkfield illumination of the depths and lower bank of the principal sulcus in the same section shows that the projection in ventral area 46 has many labeled neurons (gold, green arrows), and labeled axons (pink, white arrowhead) as they leave the halo of the injection site. Note that the dense projection abruptly terminates as the sulcus curves towards the upper bank of the principal sulcus, towards dorsal area 46. The magnified site at the lower right inset (blue arrow, brightfield illumination) shows only a few scattered labeled neurons in dorsal area 46 (white arrowheads), taken from the region with the corresponding blue arrows in (A, brightfield) and (B, darkfield). In contrast, the “straight” projection in the arcuate sulcus has many labeled neurons (lower left inset in [B], red arrow; darkfield illumination). The section was counterstained with neutral red.(C) Low-power darkfield photomicrograph of a coronal section through the caudal prefrontal cortex of a rhesus monkey brain showing the halo of the injection site in area OPAll/OPro (white area, bottom, center), and a resultant robust projection site of labeled neurons (white) arranged in a columnar pattern in area 25 (white arrows). The labeled fibers (white) around the putamen (Put) and in the internal capsule (interposed between the caudate and putamen, white) link the injection site with subcortical structures.(D) The columns of labeled neurons are shown at higher magnification. The inferiorly situated broad column of neurons (thick arrow) has a fairly straight course from the injection site, while the one above is deflected. Axons leaving the halo of the injection site are visible at this level (white fibers in white matter, which appears blue under darkfield illumination).Scale bars: (A), (C), 1 mm; (B), (D), 0.5 mm. Orientation axes: Medial, is to the left; dorsal, at the top. |
PMC1409812_pcbi-0020022-g004_4896.jpg | What stands out most in this visual? | Examples of the Relationship of Projection Density to Axonal Trajectory(A) Low-power brightfield photomicrograph of a coronal section through the posterior prefrontal cortex of a rhesus monkey brain, showing the halo of an injection of HRP-WGA in ventral area 46, below the principal sulcus (dark area). Green arrows point to a projection site in area 46 in the depths of the lower bank of the principal sulcus (dark blotch). Another projection is found in the upper bank of the lower limb of the arcuate (“A”) sulcus (dark blotch, red arrow); axons from these projection sites can take a mildly deflected or straight course to the injection site.(B) Top: higher magnification under darkfield illumination of the depths and lower bank of the principal sulcus in the same section shows that the projection in ventral area 46 has many labeled neurons (gold, green arrows), and labeled axons (pink, white arrowhead) as they leave the halo of the injection site. Note that the dense projection abruptly terminates as the sulcus curves towards the upper bank of the principal sulcus, towards dorsal area 46. The magnified site at the lower right inset (blue arrow, brightfield illumination) shows only a few scattered labeled neurons in dorsal area 46 (white arrowheads), taken from the region with the corresponding blue arrows in (A, brightfield) and (B, darkfield). In contrast, the “straight” projection in the arcuate sulcus has many labeled neurons (lower left inset in [B], red arrow; darkfield illumination). The section was counterstained with neutral red.(C) Low-power darkfield photomicrograph of a coronal section through the caudal prefrontal cortex of a rhesus monkey brain showing the halo of the injection site in area OPAll/OPro (white area, bottom, center), and a resultant robust projection site of labeled neurons (white) arranged in a columnar pattern in area 25 (white arrows). The labeled fibers (white) around the putamen (Put) and in the internal capsule (interposed between the caudate and putamen, white) link the injection site with subcortical structures.(D) The columns of labeled neurons are shown at higher magnification. The inferiorly situated broad column of neurons (thick arrow) has a fairly straight course from the injection site, while the one above is deflected. Axons leaving the halo of the injection site are visible at this level (white fibers in white matter, which appears blue under darkfield illumination).Scale bars: (A), (C), 1 mm; (B), (D), 0.5 mm. Orientation axes: Medial, is to the left; dorsal, at the top. |
PMC1409812_pcbi-0020022-g004_4895.jpg | What is the principal component of this image? | Examples of the Relationship of Projection Density to Axonal Trajectory(A) Low-power brightfield photomicrograph of a coronal section through the posterior prefrontal cortex of a rhesus monkey brain, showing the halo of an injection of HRP-WGA in ventral area 46, below the principal sulcus (dark area). Green arrows point to a projection site in area 46 in the depths of the lower bank of the principal sulcus (dark blotch). Another projection is found in the upper bank of the lower limb of the arcuate (“A”) sulcus (dark blotch, red arrow); axons from these projection sites can take a mildly deflected or straight course to the injection site.(B) Top: higher magnification under darkfield illumination of the depths and lower bank of the principal sulcus in the same section shows that the projection in ventral area 46 has many labeled neurons (gold, green arrows), and labeled axons (pink, white arrowhead) as they leave the halo of the injection site. Note that the dense projection abruptly terminates as the sulcus curves towards the upper bank of the principal sulcus, towards dorsal area 46. The magnified site at the lower right inset (blue arrow, brightfield illumination) shows only a few scattered labeled neurons in dorsal area 46 (white arrowheads), taken from the region with the corresponding blue arrows in (A, brightfield) and (B, darkfield). In contrast, the “straight” projection in the arcuate sulcus has many labeled neurons (lower left inset in [B], red arrow; darkfield illumination). The section was counterstained with neutral red.(C) Low-power darkfield photomicrograph of a coronal section through the caudal prefrontal cortex of a rhesus monkey brain showing the halo of the injection site in area OPAll/OPro (white area, bottom, center), and a resultant robust projection site of labeled neurons (white) arranged in a columnar pattern in area 25 (white arrows). The labeled fibers (white) around the putamen (Put) and in the internal capsule (interposed between the caudate and putamen, white) link the injection site with subcortical structures.(D) The columns of labeled neurons are shown at higher magnification. The inferiorly situated broad column of neurons (thick arrow) has a fairly straight course from the injection site, while the one above is deflected. Axons leaving the halo of the injection site are visible at this level (white fibers in white matter, which appears blue under darkfield illumination).Scale bars: (A), (C), 1 mm; (B), (D), 0.5 mm. Orientation axes: Medial, is to the left; dorsal, at the top. |
PMC1410747_F1_4904.jpg | Can you identify the primary element in this image? | EGFR overexpression and gene amplification in MBCs. Photomicrographs of (a) a spindle cell metaplastic breast carcinoma (haematoxylin and eosin) showing (b) grade 3+ immunohistochemical positivity for EGFR and (c) EGFR gene amplification (>5 signals per nucleus [CISH]). Inset in panel c: note the bizarre neoplastic cell with more than 10 copies of EGFR. (d) Breast carcinoma with squamous metaplasia (haematoxylin and eosin) with (e) EGFR grade 3+ immunohistochemical positivity. (f) CISH demonstrating EGFR amplification (clusters of signals in the nuclei of neoplastic cells). Note the presence of one or two signals in the nuclei of stromal cells (arrowheads). CISH, chromogenic in situ hybridization; EGFR, epidermal growth factor receptor; MBC, metaplastic breast carcinoma. |
PMC1410747_F1_4902.jpg | What's the most prominent thing you notice in this picture? | EGFR overexpression and gene amplification in MBCs. Photomicrographs of (a) a spindle cell metaplastic breast carcinoma (haematoxylin and eosin) showing (b) grade 3+ immunohistochemical positivity for EGFR and (c) EGFR gene amplification (>5 signals per nucleus [CISH]). Inset in panel c: note the bizarre neoplastic cell with more than 10 copies of EGFR. (d) Breast carcinoma with squamous metaplasia (haematoxylin and eosin) with (e) EGFR grade 3+ immunohistochemical positivity. (f) CISH demonstrating EGFR amplification (clusters of signals in the nuclei of neoplastic cells). Note the presence of one or two signals in the nuclei of stromal cells (arrowheads). CISH, chromogenic in situ hybridization; EGFR, epidermal growth factor receptor; MBC, metaplastic breast carcinoma. |
PMC1410747_F1_4900.jpg | What is shown in this image? | EGFR overexpression and gene amplification in MBCs. Photomicrographs of (a) a spindle cell metaplastic breast carcinoma (haematoxylin and eosin) showing (b) grade 3+ immunohistochemical positivity for EGFR and (c) EGFR gene amplification (>5 signals per nucleus [CISH]). Inset in panel c: note the bizarre neoplastic cell with more than 10 copies of EGFR. (d) Breast carcinoma with squamous metaplasia (haematoxylin and eosin) with (e) EGFR grade 3+ immunohistochemical positivity. (f) CISH demonstrating EGFR amplification (clusters of signals in the nuclei of neoplastic cells). Note the presence of one or two signals in the nuclei of stromal cells (arrowheads). CISH, chromogenic in situ hybridization; EGFR, epidermal growth factor receptor; MBC, metaplastic breast carcinoma. |
PMC1410747_F1_4901.jpg | What does this image primarily show? | EGFR overexpression and gene amplification in MBCs. Photomicrographs of (a) a spindle cell metaplastic breast carcinoma (haematoxylin and eosin) showing (b) grade 3+ immunohistochemical positivity for EGFR and (c) EGFR gene amplification (>5 signals per nucleus [CISH]). Inset in panel c: note the bizarre neoplastic cell with more than 10 copies of EGFR. (d) Breast carcinoma with squamous metaplasia (haematoxylin and eosin) with (e) EGFR grade 3+ immunohistochemical positivity. (f) CISH demonstrating EGFR amplification (clusters of signals in the nuclei of neoplastic cells). Note the presence of one or two signals in the nuclei of stromal cells (arrowheads). CISH, chromogenic in situ hybridization; EGFR, epidermal growth factor receptor; MBC, metaplastic breast carcinoma. |
PMC1410747_F1_4903.jpg | What does this image primarily show? | EGFR overexpression and gene amplification in MBCs. Photomicrographs of (a) a spindle cell metaplastic breast carcinoma (haematoxylin and eosin) showing (b) grade 3+ immunohistochemical positivity for EGFR and (c) EGFR gene amplification (>5 signals per nucleus [CISH]). Inset in panel c: note the bizarre neoplastic cell with more than 10 copies of EGFR. (d) Breast carcinoma with squamous metaplasia (haematoxylin and eosin) with (e) EGFR grade 3+ immunohistochemical positivity. (f) CISH demonstrating EGFR amplification (clusters of signals in the nuclei of neoplastic cells). Note the presence of one or two signals in the nuclei of stromal cells (arrowheads). CISH, chromogenic in situ hybridization; EGFR, epidermal growth factor receptor; MBC, metaplastic breast carcinoma. |
PMC1410767_F2_4906.jpg | What is being portrayed in this visual content? | DHEA and DHEA8354 induce cellular senescence, inhibit cell proliferation and increase apoptosis in mammary tumors. (a-c) Cell proliferation in control mammary tumors (a,b) and in tumors treated with dehydroepiandrosterone (DHEA) (c). DHEA significantly decreased the proportion of bromodeoxyuridine-labeled cells (c). The slide was counterstained with hematoxylin; original magnification × 100. (d-f) DHEA-induced cellular senescence (SA-β-Gal-stained cells) in normal lobular cells (d, arrows) and in mammary tumors (e and f, arrows). (g,h) p21 and p16 were expressed in most mammary tumor cells. DHEA also induced tumor disintegration and in these areas p16 (arrows) was preferentially detected in tumor areas where SA-β-Gal-stained cells were also identified. |
PMC1410767_F2_4913.jpg | What is the focal point of this photograph? | DHEA and DHEA8354 induce cellular senescence, inhibit cell proliferation and increase apoptosis in mammary tumors. (a-c) Cell proliferation in control mammary tumors (a,b) and in tumors treated with dehydroepiandrosterone (DHEA) (c). DHEA significantly decreased the proportion of bromodeoxyuridine-labeled cells (c). The slide was counterstained with hematoxylin; original magnification × 100. (d-f) DHEA-induced cellular senescence (SA-β-Gal-stained cells) in normal lobular cells (d, arrows) and in mammary tumors (e and f, arrows). (g,h) p21 and p16 were expressed in most mammary tumor cells. DHEA also induced tumor disintegration and in these areas p16 (arrows) was preferentially detected in tumor areas where SA-β-Gal-stained cells were also identified. |
PMC1410767_F2_4912.jpg | What is the core subject represented in this visual? | DHEA and DHEA8354 induce cellular senescence, inhibit cell proliferation and increase apoptosis in mammary tumors. (a-c) Cell proliferation in control mammary tumors (a,b) and in tumors treated with dehydroepiandrosterone (DHEA) (c). DHEA significantly decreased the proportion of bromodeoxyuridine-labeled cells (c). The slide was counterstained with hematoxylin; original magnification × 100. (d-f) DHEA-induced cellular senescence (SA-β-Gal-stained cells) in normal lobular cells (d, arrows) and in mammary tumors (e and f, arrows). (g,h) p21 and p16 were expressed in most mammary tumor cells. DHEA also induced tumor disintegration and in these areas p16 (arrows) was preferentially detected in tumor areas where SA-β-Gal-stained cells were also identified. |
PMC1410767_F2_4905.jpg | What is the dominant medical problem in this image? | DHEA and DHEA8354 induce cellular senescence, inhibit cell proliferation and increase apoptosis in mammary tumors. (a-c) Cell proliferation in control mammary tumors (a,b) and in tumors treated with dehydroepiandrosterone (DHEA) (c). DHEA significantly decreased the proportion of bromodeoxyuridine-labeled cells (c). The slide was counterstained with hematoxylin; original magnification × 100. (d-f) DHEA-induced cellular senescence (SA-β-Gal-stained cells) in normal lobular cells (d, arrows) and in mammary tumors (e and f, arrows). (g,h) p21 and p16 were expressed in most mammary tumor cells. DHEA also induced tumor disintegration and in these areas p16 (arrows) was preferentially detected in tumor areas where SA-β-Gal-stained cells were also identified. |
PMC1410767_F2_4907.jpg | What does this image primarily show? | DHEA and DHEA8354 induce cellular senescence, inhibit cell proliferation and increase apoptosis in mammary tumors. (a-c) Cell proliferation in control mammary tumors (a,b) and in tumors treated with dehydroepiandrosterone (DHEA) (c). DHEA significantly decreased the proportion of bromodeoxyuridine-labeled cells (c). The slide was counterstained with hematoxylin; original magnification × 100. (d-f) DHEA-induced cellular senescence (SA-β-Gal-stained cells) in normal lobular cells (d, arrows) and in mammary tumors (e and f, arrows). (g,h) p21 and p16 were expressed in most mammary tumor cells. DHEA also induced tumor disintegration and in these areas p16 (arrows) was preferentially detected in tumor areas where SA-β-Gal-stained cells were also identified. |
PMC1410767_F2_4909.jpg | What key item or scene is captured in this photo? | DHEA and DHEA8354 induce cellular senescence, inhibit cell proliferation and increase apoptosis in mammary tumors. (a-c) Cell proliferation in control mammary tumors (a,b) and in tumors treated with dehydroepiandrosterone (DHEA) (c). DHEA significantly decreased the proportion of bromodeoxyuridine-labeled cells (c). The slide was counterstained with hematoxylin; original magnification × 100. (d-f) DHEA-induced cellular senescence (SA-β-Gal-stained cells) in normal lobular cells (d, arrows) and in mammary tumors (e and f, arrows). (g,h) p21 and p16 were expressed in most mammary tumor cells. DHEA also induced tumor disintegration and in these areas p16 (arrows) was preferentially detected in tumor areas where SA-β-Gal-stained cells were also identified. |
PMC1410767_F2_4911.jpg | What's the most prominent thing you notice in this picture? | DHEA and DHEA8354 induce cellular senescence, inhibit cell proliferation and increase apoptosis in mammary tumors. (a-c) Cell proliferation in control mammary tumors (a,b) and in tumors treated with dehydroepiandrosterone (DHEA) (c). DHEA significantly decreased the proportion of bromodeoxyuridine-labeled cells (c). The slide was counterstained with hematoxylin; original magnification × 100. (d-f) DHEA-induced cellular senescence (SA-β-Gal-stained cells) in normal lobular cells (d, arrows) and in mammary tumors (e and f, arrows). (g,h) p21 and p16 were expressed in most mammary tumor cells. DHEA also induced tumor disintegration and in these areas p16 (arrows) was preferentially detected in tumor areas where SA-β-Gal-stained cells were also identified. |
PMC1410767_F2_4910.jpg | What's the most prominent thing you notice in this picture? | DHEA and DHEA8354 induce cellular senescence, inhibit cell proliferation and increase apoptosis in mammary tumors. (a-c) Cell proliferation in control mammary tumors (a,b) and in tumors treated with dehydroepiandrosterone (DHEA) (c). DHEA significantly decreased the proportion of bromodeoxyuridine-labeled cells (c). The slide was counterstained with hematoxylin; original magnification × 100. (d-f) DHEA-induced cellular senescence (SA-β-Gal-stained cells) in normal lobular cells (d, arrows) and in mammary tumors (e and f, arrows). (g,h) p21 and p16 were expressed in most mammary tumor cells. DHEA also induced tumor disintegration and in these areas p16 (arrows) was preferentially detected in tumor areas where SA-β-Gal-stained cells were also identified. |
PMC1413543_F2_4914.jpg | What is shown in this image? | Radiograph of Alta humeral nail. Post operative radiograph of the Alta humeral nail inserted for treatment of a pathological fracture of the humeral diaphysis. Cement can be seen in situ around the nail which is injected via the proximal entry hole prior to insertion of the nail. |
PMC1413548_F1_4921.jpg | What is the focal point of this photograph? | Follicle Selection. Depiction of a representative Graafian follicle (pig) at the largest cross-sectional diameter (a), and a representative preantral follicle (hamster) at the midsection (b) and examples of diameter measurements with and without inclusion of the thecal layer, (c,d) respectively. |
PMC1413548_F1_4923.jpg | What key item or scene is captured in this photo? | Follicle Selection. Depiction of a representative Graafian follicle (pig) at the largest cross-sectional diameter (a), and a representative preantral follicle (hamster) at the midsection (b) and examples of diameter measurements with and without inclusion of the thecal layer, (c,d) respectively. |
PMC1413548_F1_4922.jpg | What key item or scene is captured in this photo? | Follicle Selection. Depiction of a representative Graafian follicle (pig) at the largest cross-sectional diameter (a), and a representative preantral follicle (hamster) at the midsection (b) and examples of diameter measurements with and without inclusion of the thecal layer, (c,d) respectively. |
PMC1413548_F1_4924.jpg | What is shown in this image? | Follicle Selection. Depiction of a representative Graafian follicle (pig) at the largest cross-sectional diameter (a), and a representative preantral follicle (hamster) at the midsection (b) and examples of diameter measurements with and without inclusion of the thecal layer, (c,d) respectively. |
PMC1413548_F2_4919.jpg | What is the main focus of this visual representation? | Follicular Stages of Maturation. Depiction of representative primordial (pig) (a), primary (pig) (b), preantral (hamster) (c), incipient antral (mouse) (d), small antral (hamster) (e) and Graafian (pig) (f) follicles. |
PMC1413548_F2_4918.jpg | What object or scene is depicted here? | Follicular Stages of Maturation. Depiction of representative primordial (pig) (a), primary (pig) (b), preantral (hamster) (c), incipient antral (mouse) (d), small antral (hamster) (e) and Graafian (pig) (f) follicles. |
PMC1413548_F2_4916.jpg | What is shown in this image? | Follicular Stages of Maturation. Depiction of representative primordial (pig) (a), primary (pig) (b), preantral (hamster) (c), incipient antral (mouse) (d), small antral (hamster) (e) and Graafian (pig) (f) follicles. |
PMC1413571_pbio-0040100-g003_4929.jpg | What is the main focus of this visual representation? | Practice-Related Activations(A) Brain activity during exploration of the virtual environment (Session IV). Cross hair shows hippocampus activation (22 −26 −6 mm,
p
corr < 0.005) superimposed on participants' average anatomical T1-weighted MRI image. Color bars indicate magnitude of effect size. (B) Brain activity during practice of the procedural serial RT task (Session IV). Cross hair shows cerebellum activation (12 −74 −22 mm,
p
corr < 0.05).
|
PMC1413571_pbio-0040100-g003_4926.jpg | What's the most prominent thing you notice in this picture? | Practice-Related Activations(A) Brain activity during exploration of the virtual environment (Session IV). Cross hair shows hippocampus activation (22 −26 −6 mm,
p
corr < 0.005) superimposed on participants' average anatomical T1-weighted MRI image. Color bars indicate magnitude of effect size. (B) Brain activity during practice of the procedural serial RT task (Session IV). Cross hair shows cerebellum activation (12 −74 −22 mm,
p
corr < 0.05).
|
PMC1413990_F1_4931.jpg | What stands out most in this visual? | HELUs are much larger than normal TDLUs. This photomicrograph shows a normal type 1 TDLU adjacent to a typical HELU. In this example, the TDLU measures about 0.4 mm in diameter, contains about 150 cells within this area, and approximately 4000 total cells. The HELU measures about 2.0 mm in diameter, contains about 1500 cells within this area, and approximately 200,000 total cells (i.e. a 50-fold increase relative to the TDLU). Estimates of cell counts were based on calculations assuming all cells measure 10 μm in thickness and are evenly distributed within a sphere the diameter of the TDLU or HELU. Typical HELUs measure between 1 and 4 mm in diameter, and so the magnitude of the hyperplasia may be somewhat smaller or larger than shown in this example, depending on the size. HELU, hyperplastic enlarged lobular unit; TDLU, terminal duct lobular unit. |
PMC1420290_F4_4933.jpg | What is the principal component of this image? | Distribution of FITC-labelled siRNA in M1 cells in vitro. M1 cells were transfected with Lipofectamine 2000-complexed FITC-labelled siRNA. At indicated time-points after transfection cells were harvested and processed for confocal microscopy. Nuclei were stained with DAPI and are shown in blue (left panel), FITC signal is shown in green (right panel). A and B show biodistribution 30 min after transfection, C and D show biodistribution 24 hrs after transfection. |
PMC1420290_F4_4935.jpg | What is the core subject represented in this visual? | Distribution of FITC-labelled siRNA in M1 cells in vitro. M1 cells were transfected with Lipofectamine 2000-complexed FITC-labelled siRNA. At indicated time-points after transfection cells were harvested and processed for confocal microscopy. Nuclei were stained with DAPI and are shown in blue (left panel), FITC signal is shown in green (right panel). A and B show biodistribution 30 min after transfection, C and D show biodistribution 24 hrs after transfection. |
PMC1420290_F5_4936.jpg | What is the central feature of this picture? | Distribution of FITC-labelled siRNA and asODN in mouse lung. FITC-labelled asODN (a) and siRNA (b) (160 μg/mouse) were complexed to GL67 and "sniffed" into mouse lung. One or 24 hours after transfection the lungs were paraffin-embedded and processed for confocal microscopy. Nuclei are shown in blue, FITC signal is shown in green. Arrow indicates alveolar macrophage. |
PMC1420290_F5_4937.jpg | What does this image primarily show? | Distribution of FITC-labelled siRNA and asODN in mouse lung. FITC-labelled asODN (a) and siRNA (b) (160 μg/mouse) were complexed to GL67 and "sniffed" into mouse lung. One or 24 hours after transfection the lungs were paraffin-embedded and processed for confocal microscopy. Nuclei are shown in blue, FITC signal is shown in green. Arrow indicates alveolar macrophage. |
PMC1420290_F9_4939.jpg | What stands out most in this visual? | Distribution of FITC-labelled asODN in the mouse nose in vivo. FITC-labelled asODN (80 μg/mouse) were complexed with GL67 and perfused into the nasal cavity. Twenty-four hours later the nasal septum was extracted, paraffin-embedded and processed for confocal microscopy. Nuclei are shown in blue, FITC signal is shown in green. Arrows indicate the surface epithelium. A and B are images from two different animals showing the highest (A) and lowest (B) levels of uptake seen. |
PMC1420304_F4_4941.jpg | What is shown in this image? | 0-day latency: SEM micrograph view of "honey-comb" like structure of immature new formed bone trabeculae with abundant osteoblasts embedded into lacuna × 35. |
PMC1420304_F5_4943.jpg | Can you identify the primary element in this image? | The most central zone of the 0-day latency group, observation of low density of SEM micrograph demonstrated fibrous tissue with some osteoid were scattering × 30. |
PMC1420304_F6_4940.jpg | What is the main focus of this visual representation? | 4-day latency: SEM micrograph view of immature new formed bone with osteoblasts embedded into lacuna × 400. |
PMC1420304_F7_4944.jpg | What object or scene is depicted here? | The most central zone of 4-day latency group, observation of low density of SEM micrograph demonstrated fibrous tissue with some osteoid were scattering × 400. |
PMC1420304_F8_4942.jpg | What is the principal component of this image? | SEM micrograph view of 7-day latency: The gap was totally filled with dense new bone trabecula. |
PMC1420313_F2_4945.jpg | What is the central feature of this picture? | Computed tomography revealed a right lower lobe soft tissue density mass. |
PMC1420324_F2_4947.jpg | What is the main focus of this visual representation? | Successful Rd-RCA I lectin guided capture of endothelial cells under inverted 40× magnification. A: Fluorescent labeled angiogenic and functional vessels are distinguished from the surrounding epithelium prior to performing LCM. B: A low-powered infrared laser was pulsed over the targeted cells, which expanded the film on the cap and extracted the entire vessel. C: An intact vessel containing a homogeneous cell population generated for molecular analysis. The presence of RCA-Rhodamine labeled endothelial cells on the "cap" image and the absence of the targeted cells in the "after" microdissection image confirmed successful capture. A power setting of 40 mW and duration of 450 μs were utilized to obtain a 5.0–6.0 μm diameter laser spot size, which permitted precise selection of endothelium using the Pix Cell II Instrument. |
PMC1420324_F2_4948.jpg | What is the focal point of this photograph? | Successful Rd-RCA I lectin guided capture of endothelial cells under inverted 40× magnification. A: Fluorescent labeled angiogenic and functional vessels are distinguished from the surrounding epithelium prior to performing LCM. B: A low-powered infrared laser was pulsed over the targeted cells, which expanded the film on the cap and extracted the entire vessel. C: An intact vessel containing a homogeneous cell population generated for molecular analysis. The presence of RCA-Rhodamine labeled endothelial cells on the "cap" image and the absence of the targeted cells in the "after" microdissection image confirmed successful capture. A power setting of 40 mW and duration of 450 μs were utilized to obtain a 5.0–6.0 μm diameter laser spot size, which permitted precise selection of endothelium using the Pix Cell II Instrument. |
PMC1420324_F2_4949.jpg | What does this image primarily show? | Successful Rd-RCA I lectin guided capture of endothelial cells under inverted 40× magnification. A: Fluorescent labeled angiogenic and functional vessels are distinguished from the surrounding epithelium prior to performing LCM. B: A low-powered infrared laser was pulsed over the targeted cells, which expanded the film on the cap and extracted the entire vessel. C: An intact vessel containing a homogeneous cell population generated for molecular analysis. The presence of RCA-Rhodamine labeled endothelial cells on the "cap" image and the absence of the targeted cells in the "after" microdissection image confirmed successful capture. A power setting of 40 mW and duration of 450 μs were utilized to obtain a 5.0–6.0 μm diameter laser spot size, which permitted precise selection of endothelium using the Pix Cell II Instrument. |
PMC1420325_F1_4950.jpg | What is the focal point of this photograph? | CT scan demonstrated a large, contrast enhancing soft tissue lesion pushing the larynx medially. |
PMC1420325_F2_4953.jpg | What is being portrayed in this visual content? | The tumor between the parapharyngeal space and the upper pole of right thyroid lobe was narrowing the airway passage and displacing the carotid artery and the internal jugular vein laterally on MRI. |
PMC1420325_F3_4952.jpg | Can you identify the primary element in this image? | The rich vascularity of the tumor was demonstrated on angiography. Lateral and anteroposterior view. |
PMC1420325_F4_4951.jpg | What is the dominant medical problem in this image? | The rich vascularity of the tumor was demonstrated on angiography. Lateral and anteroposterior view. |
PMC1420331_F1_4955.jpg | What can you see in this picture? | Immunohistochemistry of the Prostate. Representative photos of the immunohistochemistry staining of the epithelium (A) and endothelium (B) of the same area of tumor using diaminobenzidine staining. Panel C is a higher magnification of the endothelial staining to better demonstrate the dark staining of the endothelial cells. |
PMC1420331_F1_4954.jpg | What stands out most in this visual? | Immunohistochemistry of the Prostate. Representative photos of the immunohistochemistry staining of the epithelium (A) and endothelium (B) of the same area of tumor using diaminobenzidine staining. Panel C is a higher magnification of the endothelial staining to better demonstrate the dark staining of the endothelial cells. |
PMC1420338_F1_4957.jpg | Describe the main subject of this image. | This figure shows an unzoomed B-mode still image obtained during carotid scanning. |
PMC1420389_pmed-0030131-g002_4959.jpg | What can you see in this picture? | Radionuclide Imaging Showing a Reversible Perfusion Defect in the SeptumThe defect is shown by decreased tracer concentration (white arrows) in the whole of the septum after stress (seen in the short axis view). |
PMC1420389_pmed-0030131-g002_4961.jpg | What is the central feature of this picture? | Radionuclide Imaging Showing a Reversible Perfusion Defect in the SeptumThe defect is shown by decreased tracer concentration (white arrows) in the whole of the septum after stress (seen in the short axis view). |
PMC1420389_pmed-0030131-g002_4960.jpg | What object or scene is depicted here? | Radionuclide Imaging Showing a Reversible Perfusion Defect in the SeptumThe defect is shown by decreased tracer concentration (white arrows) in the whole of the septum after stress (seen in the short axis view). |
PMC1420389_pmed-0030131-g003_4962.jpg | What is the principal component of this image? | MCE: Apical Three-Chamber View Assessment(A) Apical three-chamber view assessment at rest. This assessment demonstrates a correspondingly reduced contrast uptake in the apical sub-endocardium representing an infarcted region (two black arrows) whilst the remaining myocardium shows normal opacification.(B) Apical three-chamber view assessment following stress. This assessment demonstrates markedly reduced contrast uptake in the entire septum (black arrows) suggesting mid-LAD disease. |
PMC1420389_pmed-0030131-g003_4963.jpg | What is the central feature of this picture? | MCE: Apical Three-Chamber View Assessment(A) Apical three-chamber view assessment at rest. This assessment demonstrates a correspondingly reduced contrast uptake in the apical sub-endocardium representing an infarcted region (two black arrows) whilst the remaining myocardium shows normal opacification.(B) Apical three-chamber view assessment following stress. This assessment demonstrates markedly reduced contrast uptake in the entire septum (black arrows) suggesting mid-LAD disease. |
PMC1420389_pmed-0030131-g004_4958.jpg | What's the most prominent thing you notice in this picture? | Coronary Angiography Showing Flow-Limiting Coronary Stenosis in the Mid-LADFlow-limiting coronary stenosis is designated by the black arrow. |
PMC1421389_F4_4968.jpg | What stands out most in this visual? | SEM of implantation sites in tibia specimens at different magnifications. Bone-implant interfaces are shown after 28 days of osseointegration. |
PMC1421389_F5_4964.jpg | Describe the main subject of this image. | SEM of implantation sites in tibia specimens at different magnifications. Bone-implant interfaces are shown after 28 days of osseointegration. |
PMC1421389_F7_4967.jpg | What stands out most in this visual? | Laminar bone structure as revealed by fluorescence microscopy without labelling (healing period 28 days; magnification × 40). |
PMC1421389_F8_4965.jpg | What is the principal component of this image? | Laminar bone structure as revealed by fluorescence microscopy without labelling (healing period 28 days; magnification × 60). |
PMC1421389_F8_4966.jpg | What stands out most in this visual? | Laminar bone structure as revealed by fluorescence microscopy without labelling (healing period 28 days; magnification × 60). |
PMC1421416_F1_4970.jpg | What is shown in this image? | Panel A: Low magnification of the liver biopsy (HE 120 ×). The portal tract (PT) is infiltrated by a mixed inflammatory reaction. Microgranulomatous cell reaction (G) is visible. Panel B: Typical "spider-web" network pattern at hepatic angiography in the setting of partial Budd-Chiari syndrome. Panel C: Abdominal CT scan showing a fresh thrombus in the ostium of the right hepatic vein (arrow). Panel D: Low magnification of liver biopsy showing marked sinusoidal dilatation (S) and congestion around the central vein (CV). PV: portal vein. |
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