image stringlengths 20 66 | question stringclasses 16
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PMC1523202_F3_6211.jpg | What is being portrayed in this visual content? | Enlarged pericardial cavity in glo mutant. Compared to a control embryo (panel A), the pericardial cavity (pc) is much enlarged in a cadherin2 morphant (panel B) and a glo mutant embryo (panels C and D). All panels are images from live embryos showing lateral views (anterior to the left and dorsal up) of the pericardial cavity and heart. Panel D is a higher magnification of the pericardial cavity showing in panel C. |
PMC1523202_F3_6212.jpg | What is the principal component of this image? | Enlarged pericardial cavity in glo mutant. Compared to a control embryo (panel A), the pericardial cavity (pc) is much enlarged in a cadherin2 morphant (panel B) and a glo mutant embryo (panels C and D). All panels are images from live embryos showing lateral views (anterior to the left and dorsal up) of the pericardial cavity and heart. Panel D is a higher magnification of the pericardial cavity showing in panel C. |
PMC1523227_pbio-0040260-g003_6213.jpg | What does this image primarily show? | apoEb, midkine a, and
thymosin β
4 Are Expressed around the Wound Site during Zebrafish Heart Regeneration
Spatial expression patterns of
apoEb,
midkine a, and
thymosin β
4 in sham-operated hearts (uncut) and regenerating hearts at 3, 7, and 14 dpa were determined by in situ hybridization.
(A) The expression pattern of
apoEb was determined using a DIG-labeled antisense probe.
apoEb was highly expressed at 3 dpa; its punctate expression suggests that it is expressed by infiltrating macrophages (see the higher magnification image in the inset).
(B) Expression level of
midkine a was upregulated from 3 dpa, reaches a peak at 7 dpa and lasts until 14 dpa. It appears to be expressed around the wound site in the compact layer of myocardium and the epicardium.
(C) The expression pattern of
thymosin β
4 was determined using a radioactive antisense probe.
thymosin β
4 appears to be expressed around the wound and surrounding compact myocardium. Sense probes for each gene were used as negative controls. A dashed line marks the amputation plane.
|
PMC1523227_pbio-0040260-g003_6214.jpg | What is the central feature of this picture? | apoEb, midkine a, and
thymosin β
4 Are Expressed around the Wound Site during Zebrafish Heart Regeneration
Spatial expression patterns of
apoEb,
midkine a, and
thymosin β
4 in sham-operated hearts (uncut) and regenerating hearts at 3, 7, and 14 dpa were determined by in situ hybridization.
(A) The expression pattern of
apoEb was determined using a DIG-labeled antisense probe.
apoEb was highly expressed at 3 dpa; its punctate expression suggests that it is expressed by infiltrating macrophages (see the higher magnification image in the inset).
(B) Expression level of
midkine a was upregulated from 3 dpa, reaches a peak at 7 dpa and lasts until 14 dpa. It appears to be expressed around the wound site in the compact layer of myocardium and the epicardium.
(C) The expression pattern of
thymosin β
4 was determined using a radioactive antisense probe.
thymosin β
4 appears to be expressed around the wound and surrounding compact myocardium. Sense probes for each gene were used as negative controls. A dashed line marks the amputation plane.
|
PMC1523227_pbio-0040260-g003_6215.jpg | What key item or scene is captured in this photo? | apoEb, midkine a, and
thymosin β
4 Are Expressed around the Wound Site during Zebrafish Heart Regeneration
Spatial expression patterns of
apoEb,
midkine a, and
thymosin β
4 in sham-operated hearts (uncut) and regenerating hearts at 3, 7, and 14 dpa were determined by in situ hybridization.
(A) The expression pattern of
apoEb was determined using a DIG-labeled antisense probe.
apoEb was highly expressed at 3 dpa; its punctate expression suggests that it is expressed by infiltrating macrophages (see the higher magnification image in the inset).
(B) Expression level of
midkine a was upregulated from 3 dpa, reaches a peak at 7 dpa and lasts until 14 dpa. It appears to be expressed around the wound site in the compact layer of myocardium and the epicardium.
(C) The expression pattern of
thymosin β
4 was determined using a radioactive antisense probe.
thymosin β
4 appears to be expressed around the wound and surrounding compact myocardium. Sense probes for each gene were used as negative controls. A dashed line marks the amputation plane.
|
PMC1523227_pbio-0040260-g003_6226.jpg | What object or scene is depicted here? | apoEb, midkine a, and
thymosin β
4 Are Expressed around the Wound Site during Zebrafish Heart Regeneration
Spatial expression patterns of
apoEb,
midkine a, and
thymosin β
4 in sham-operated hearts (uncut) and regenerating hearts at 3, 7, and 14 dpa were determined by in situ hybridization.
(A) The expression pattern of
apoEb was determined using a DIG-labeled antisense probe.
apoEb was highly expressed at 3 dpa; its punctate expression suggests that it is expressed by infiltrating macrophages (see the higher magnification image in the inset).
(B) Expression level of
midkine a was upregulated from 3 dpa, reaches a peak at 7 dpa and lasts until 14 dpa. It appears to be expressed around the wound site in the compact layer of myocardium and the epicardium.
(C) The expression pattern of
thymosin β
4 was determined using a radioactive antisense probe.
thymosin β
4 appears to be expressed around the wound and surrounding compact myocardium. Sense probes for each gene were used as negative controls. A dashed line marks the amputation plane.
|
PMC1523227_pbio-0040260-g003_6230.jpg | What is being portrayed in this visual content? | apoEb, midkine a, and
thymosin β
4 Are Expressed around the Wound Site during Zebrafish Heart Regeneration
Spatial expression patterns of
apoEb,
midkine a, and
thymosin β
4 in sham-operated hearts (uncut) and regenerating hearts at 3, 7, and 14 dpa were determined by in situ hybridization.
(A) The expression pattern of
apoEb was determined using a DIG-labeled antisense probe.
apoEb was highly expressed at 3 dpa; its punctate expression suggests that it is expressed by infiltrating macrophages (see the higher magnification image in the inset).
(B) Expression level of
midkine a was upregulated from 3 dpa, reaches a peak at 7 dpa and lasts until 14 dpa. It appears to be expressed around the wound site in the compact layer of myocardium and the epicardium.
(C) The expression pattern of
thymosin β
4 was determined using a radioactive antisense probe.
thymosin β
4 appears to be expressed around the wound and surrounding compact myocardium. Sense probes for each gene were used as negative controls. A dashed line marks the amputation plane.
|
PMC1523227_pbio-0040260-g003_6224.jpg | Can you identify the primary element in this image? | apoEb, midkine a, and
thymosin β
4 Are Expressed around the Wound Site during Zebrafish Heart Regeneration
Spatial expression patterns of
apoEb,
midkine a, and
thymosin β
4 in sham-operated hearts (uncut) and regenerating hearts at 3, 7, and 14 dpa were determined by in situ hybridization.
(A) The expression pattern of
apoEb was determined using a DIG-labeled antisense probe.
apoEb was highly expressed at 3 dpa; its punctate expression suggests that it is expressed by infiltrating macrophages (see the higher magnification image in the inset).
(B) Expression level of
midkine a was upregulated from 3 dpa, reaches a peak at 7 dpa and lasts until 14 dpa. It appears to be expressed around the wound site in the compact layer of myocardium and the epicardium.
(C) The expression pattern of
thymosin β
4 was determined using a radioactive antisense probe.
thymosin β
4 appears to be expressed around the wound and surrounding compact myocardium. Sense probes for each gene were used as negative controls. A dashed line marks the amputation plane.
|
PMC1523227_pbio-0040260-g003_6218.jpg | What is being portrayed in this visual content? | apoEb, midkine a, and
thymosin β
4 Are Expressed around the Wound Site during Zebrafish Heart Regeneration
Spatial expression patterns of
apoEb,
midkine a, and
thymosin β
4 in sham-operated hearts (uncut) and regenerating hearts at 3, 7, and 14 dpa were determined by in situ hybridization.
(A) The expression pattern of
apoEb was determined using a DIG-labeled antisense probe.
apoEb was highly expressed at 3 dpa; its punctate expression suggests that it is expressed by infiltrating macrophages (see the higher magnification image in the inset).
(B) Expression level of
midkine a was upregulated from 3 dpa, reaches a peak at 7 dpa and lasts until 14 dpa. It appears to be expressed around the wound site in the compact layer of myocardium and the epicardium.
(C) The expression pattern of
thymosin β
4 was determined using a radioactive antisense probe.
thymosin β
4 appears to be expressed around the wound and surrounding compact myocardium. Sense probes for each gene were used as negative controls. A dashed line marks the amputation plane.
|
PMC1523227_pbio-0040260-g003_6225.jpg | Describe the main subject of this image. | apoEb, midkine a, and
thymosin β
4 Are Expressed around the Wound Site during Zebrafish Heart Regeneration
Spatial expression patterns of
apoEb,
midkine a, and
thymosin β
4 in sham-operated hearts (uncut) and regenerating hearts at 3, 7, and 14 dpa were determined by in situ hybridization.
(A) The expression pattern of
apoEb was determined using a DIG-labeled antisense probe.
apoEb was highly expressed at 3 dpa; its punctate expression suggests that it is expressed by infiltrating macrophages (see the higher magnification image in the inset).
(B) Expression level of
midkine a was upregulated from 3 dpa, reaches a peak at 7 dpa and lasts until 14 dpa. It appears to be expressed around the wound site in the compact layer of myocardium and the epicardium.
(C) The expression pattern of
thymosin β
4 was determined using a radioactive antisense probe.
thymosin β
4 appears to be expressed around the wound and surrounding compact myocardium. Sense probes for each gene were used as negative controls. A dashed line marks the amputation plane.
|
PMC1523227_pbio-0040260-g003_6229.jpg | What is the main focus of this visual representation? | apoEb, midkine a, and
thymosin β
4 Are Expressed around the Wound Site during Zebrafish Heart Regeneration
Spatial expression patterns of
apoEb,
midkine a, and
thymosin β
4 in sham-operated hearts (uncut) and regenerating hearts at 3, 7, and 14 dpa were determined by in situ hybridization.
(A) The expression pattern of
apoEb was determined using a DIG-labeled antisense probe.
apoEb was highly expressed at 3 dpa; its punctate expression suggests that it is expressed by infiltrating macrophages (see the higher magnification image in the inset).
(B) Expression level of
midkine a was upregulated from 3 dpa, reaches a peak at 7 dpa and lasts until 14 dpa. It appears to be expressed around the wound site in the compact layer of myocardium and the epicardium.
(C) The expression pattern of
thymosin β
4 was determined using a radioactive antisense probe.
thymosin β
4 appears to be expressed around the wound and surrounding compact myocardium. Sense probes for each gene were used as negative controls. A dashed line marks the amputation plane.
|
PMC1523227_pbio-0040260-g003_6227.jpg | What is the principal component of this image? | apoEb, midkine a, and
thymosin β
4 Are Expressed around the Wound Site during Zebrafish Heart Regeneration
Spatial expression patterns of
apoEb,
midkine a, and
thymosin β
4 in sham-operated hearts (uncut) and regenerating hearts at 3, 7, and 14 dpa were determined by in situ hybridization.
(A) The expression pattern of
apoEb was determined using a DIG-labeled antisense probe.
apoEb was highly expressed at 3 dpa; its punctate expression suggests that it is expressed by infiltrating macrophages (see the higher magnification image in the inset).
(B) Expression level of
midkine a was upregulated from 3 dpa, reaches a peak at 7 dpa and lasts until 14 dpa. It appears to be expressed around the wound site in the compact layer of myocardium and the epicardium.
(C) The expression pattern of
thymosin β
4 was determined using a radioactive antisense probe.
thymosin β
4 appears to be expressed around the wound and surrounding compact myocardium. Sense probes for each gene were used as negative controls. A dashed line marks the amputation plane.
|
PMC1523227_pbio-0040260-g003_6222.jpg | What key item or scene is captured in this photo? | apoEb, midkine a, and
thymosin β
4 Are Expressed around the Wound Site during Zebrafish Heart Regeneration
Spatial expression patterns of
apoEb,
midkine a, and
thymosin β
4 in sham-operated hearts (uncut) and regenerating hearts at 3, 7, and 14 dpa were determined by in situ hybridization.
(A) The expression pattern of
apoEb was determined using a DIG-labeled antisense probe.
apoEb was highly expressed at 3 dpa; its punctate expression suggests that it is expressed by infiltrating macrophages (see the higher magnification image in the inset).
(B) Expression level of
midkine a was upregulated from 3 dpa, reaches a peak at 7 dpa and lasts until 14 dpa. It appears to be expressed around the wound site in the compact layer of myocardium and the epicardium.
(C) The expression pattern of
thymosin β
4 was determined using a radioactive antisense probe.
thymosin β
4 appears to be expressed around the wound and surrounding compact myocardium. Sense probes for each gene were used as negative controls. A dashed line marks the amputation plane.
|
PMC1523328_F4_6233.jpg | What is being portrayed in this visual content? | FRET-FLIM analysis of the MLO-calmodulin interaction. Barley MLO is a plant-specific calmodulin-binding protein that functions as a modulator of defence against the common powdery mildew pathogen [90]. YFP-tagged wild-type barley MLO or mutant variants thereof (W423R and L420R W423R, bearing amino acid substitutions in the calmodulin binding domain [90]) were co-expressed with CFP-tagged calmodulin in single barley leaf epidermal cells. FRET-FLIM analysis was performed as described in [32]. Donor fluorophore lifetimes are color-coded according to the scale indicated on top of the Figure. "Warmer" colors are indicative of shorter donor fluorophore lifetimes and thus interaction between MLO and calmodulin. Size bar, 20 μm. |
PMC1523328_F4_6231.jpg | Describe the main subject of this image. | FRET-FLIM analysis of the MLO-calmodulin interaction. Barley MLO is a plant-specific calmodulin-binding protein that functions as a modulator of defence against the common powdery mildew pathogen [90]. YFP-tagged wild-type barley MLO or mutant variants thereof (W423R and L420R W423R, bearing amino acid substitutions in the calmodulin binding domain [90]) were co-expressed with CFP-tagged calmodulin in single barley leaf epidermal cells. FRET-FLIM analysis was performed as described in [32]. Donor fluorophore lifetimes are color-coded according to the scale indicated on top of the Figure. "Warmer" colors are indicative of shorter donor fluorophore lifetimes and thus interaction between MLO and calmodulin. Size bar, 20 μm. |
PMC1523328_F4_6232.jpg | What does this image primarily show? | FRET-FLIM analysis of the MLO-calmodulin interaction. Barley MLO is a plant-specific calmodulin-binding protein that functions as a modulator of defence against the common powdery mildew pathogen [90]. YFP-tagged wild-type barley MLO or mutant variants thereof (W423R and L420R W423R, bearing amino acid substitutions in the calmodulin binding domain [90]) were co-expressed with CFP-tagged calmodulin in single barley leaf epidermal cells. FRET-FLIM analysis was performed as described in [32]. Donor fluorophore lifetimes are color-coded according to the scale indicated on top of the Figure. "Warmer" colors are indicative of shorter donor fluorophore lifetimes and thus interaction between MLO and calmodulin. Size bar, 20 μm. |
PMC1523328_F4_6234.jpg | What is shown in this image? | FRET-FLIM analysis of the MLO-calmodulin interaction. Barley MLO is a plant-specific calmodulin-binding protein that functions as a modulator of defence against the common powdery mildew pathogen [90]. YFP-tagged wild-type barley MLO or mutant variants thereof (W423R and L420R W423R, bearing amino acid substitutions in the calmodulin binding domain [90]) were co-expressed with CFP-tagged calmodulin in single barley leaf epidermal cells. FRET-FLIM analysis was performed as described in [32]. Donor fluorophore lifetimes are color-coded according to the scale indicated on top of the Figure. "Warmer" colors are indicative of shorter donor fluorophore lifetimes and thus interaction between MLO and calmodulin. Size bar, 20 μm. |
PMC1523342_F10_6238.jpg | What is shown in this image? | A real test object and its EIT reconstructed image using back projection method. |
PMC1523342_F10_6239.jpg | What is the central feature of this picture? | A real test object and its EIT reconstructed image using back projection method. |
PMC1523342_F11_6236.jpg | What does this image primarily show? | A real test object and its EIT reconstructed image using back projection method. |
PMC1523343_F7_6241.jpg | What is the dominant medical problem in this image? | Colposcopic images of mouse vaginas 12 hours after a single exposure to 2% N9, or PBS. The colposcope (Zeiss OPMI 1-SH) was set at maximum magnification (31×) and focused on the vaginal area surrounding the cervix. Column A, 2% N9, column B, PBS controls. |
PMC1523343_F7_6246.jpg | Describe the main subject of this image. | Colposcopic images of mouse vaginas 12 hours after a single exposure to 2% N9, or PBS. The colposcope (Zeiss OPMI 1-SH) was set at maximum magnification (31×) and focused on the vaginal area surrounding the cervix. Column A, 2% N9, column B, PBS controls. |
PMC1523343_F7_6243.jpg | Can you identify the primary element in this image? | Colposcopic images of mouse vaginas 12 hours after a single exposure to 2% N9, or PBS. The colposcope (Zeiss OPMI 1-SH) was set at maximum magnification (31×) and focused on the vaginal area surrounding the cervix. Column A, 2% N9, column B, PBS controls. |
PMC1523343_F7_6244.jpg | What is the main focus of this visual representation? | Colposcopic images of mouse vaginas 12 hours after a single exposure to 2% N9, or PBS. The colposcope (Zeiss OPMI 1-SH) was set at maximum magnification (31×) and focused on the vaginal area surrounding the cervix. Column A, 2% N9, column B, PBS controls. |
PMC1523343_F7_6242.jpg | What is the focal point of this photograph? | Colposcopic images of mouse vaginas 12 hours after a single exposure to 2% N9, or PBS. The colposcope (Zeiss OPMI 1-SH) was set at maximum magnification (31×) and focused on the vaginal area surrounding the cervix. Column A, 2% N9, column B, PBS controls. |
PMC1523343_F7_6245.jpg | What object or scene is depicted here? | Colposcopic images of mouse vaginas 12 hours after a single exposure to 2% N9, or PBS. The colposcope (Zeiss OPMI 1-SH) was set at maximum magnification (31×) and focused on the vaginal area surrounding the cervix. Column A, 2% N9, column B, PBS controls. |
PMC1523353_F4_6249.jpg | What is the central feature of this picture? | Colony Filtration Blots for identification of soluble protein expression in E. coli. E. coli colonies expressing domains ATS, CIDR1α and DBL1α were induced and lysed on a membrane filter. Soluble protein from each cell within the colony diffuses through the filter and is captured on a nitrocellulose membrane placed under the membrane filter [13]. Detection with antibody reagents directed against the fusion tag, shows spots indicating the presence of soluble protein. Intensity of the spot corresponds to the yield of soluble protein. The arrow shows the increasing expression of soluble protein for the PfEMP1 domain types compared. |
PMC1523353_F4_6250.jpg | What is the dominant medical problem in this image? | Colony Filtration Blots for identification of soluble protein expression in E. coli. E. coli colonies expressing domains ATS, CIDR1α and DBL1α were induced and lysed on a membrane filter. Soluble protein from each cell within the colony diffuses through the filter and is captured on a nitrocellulose membrane placed under the membrane filter [13]. Detection with antibody reagents directed against the fusion tag, shows spots indicating the presence of soluble protein. Intensity of the spot corresponds to the yield of soluble protein. The arrow shows the increasing expression of soluble protein for the PfEMP1 domain types compared. |
PMC1523362_F1_6253.jpg | What stands out most in this visual? | A. Ultrasonography of the left thorax documenting a hypoechogenic nodule in the context of the intercostal muscle, close to the underlying rib. The nodule shows intralesional vessels at Color Doppler examination. B. T1-weighted MRI showing the presence of a moderate gadolinium-contrast enhancement area in the intercostal muscle adjacent to the rib. C. FDG-PET/CT scan documenting two focuses of abnormal FDG uptake in the left hemithorax. D. Recurrence of squamous cell cervical carcinoma in the rib cage muscle. The bands of skeletal muscle are separated and infiltrated by nests of squamous carcinoma cells surrounded by desmoplasic stroma and showing areas of keratinisation. (Hematoxylin & Eosin, magnification 100×). |
PMC1523362_F1_6252.jpg | What's the most prominent thing you notice in this picture? | A. Ultrasonography of the left thorax documenting a hypoechogenic nodule in the context of the intercostal muscle, close to the underlying rib. The nodule shows intralesional vessels at Color Doppler examination. B. T1-weighted MRI showing the presence of a moderate gadolinium-contrast enhancement area in the intercostal muscle adjacent to the rib. C. FDG-PET/CT scan documenting two focuses of abnormal FDG uptake in the left hemithorax. D. Recurrence of squamous cell cervical carcinoma in the rib cage muscle. The bands of skeletal muscle are separated and infiltrated by nests of squamous carcinoma cells surrounded by desmoplasic stroma and showing areas of keratinisation. (Hematoxylin & Eosin, magnification 100×). |
PMC1523371_F1_6254.jpg | What is the focal point of this photograph? | Case 1. Contrast-enhanced CT (CECT) demonstrates a splenic laceration extending to the splenic surface from a focal hypodense cyst-like lesion. There is a large perisplenic haematoma and abdominal free fluid. |
PMC1523371_F2_6255.jpg | What is the principal component of this image? | Case 1. Splenic vessels course through the cyst-like lesions of the splenic parenchyma without mass effect. The lesions show areas of contrast enhancement on the portal venous phase of CECT. |
PMC1523371_F5_6256.jpg | What is shown in this image? | Case 2. Areas of contrast enhancement are seen more inferiorly in the spleen on CECT. These lie adjacent to a hypodense cyst-like lesion and further lacerations. The splenic capsule is disrupted anteriorly. |
PMC1524733_F1_6259.jpg | Describe the main subject of this image. | This figure illustrates significant differences in cannabis users relative to non-users in both ADC and FA. Coronal, sagittal and axial views (moving from left to right, respectively) illustrate that the apparent diffusion coefficient (ADC) for adolescent cannabis users (N = 10) was significantly (p < 0.01, cluster size >200 mm3) lower relative to non-cannabis users (N = 10) in left middle frontal gyrus (a): Talairach coordinates -41 [L],3 [A],36 [S], and posterior to the right posterior cingulate (b): 2 [R],-54 [P],4 [S] (shown in orange superimposed on the average registered MPRAGE images from all 20 subjects), and that the fractional anisotropy (FA) was significantly higher (shown in blue) in cannabis users in the left anterior cingulate (c): -16 [L],32 [A],11 [S], right medial frontal gyrus (d): 3 [R],46 [A],18 [S], left precentral gyrus (e): -32 [L],1 [A],33 [S], right inferior parietal (f): 50 [R],-38 [P],39 [S], right cingulate gyrus (g): 10 [R],-3 [P],35 [S], and left superior frontal gyrus (h): -20 [L],21 [A],45 [S]. |
PMC1524733_F1_6258.jpg | Can you identify the primary element in this image? | This figure illustrates significant differences in cannabis users relative to non-users in both ADC and FA. Coronal, sagittal and axial views (moving from left to right, respectively) illustrate that the apparent diffusion coefficient (ADC) for adolescent cannabis users (N = 10) was significantly (p < 0.01, cluster size >200 mm3) lower relative to non-cannabis users (N = 10) in left middle frontal gyrus (a): Talairach coordinates -41 [L],3 [A],36 [S], and posterior to the right posterior cingulate (b): 2 [R],-54 [P],4 [S] (shown in orange superimposed on the average registered MPRAGE images from all 20 subjects), and that the fractional anisotropy (FA) was significantly higher (shown in blue) in cannabis users in the left anterior cingulate (c): -16 [L],32 [A],11 [S], right medial frontal gyrus (d): 3 [R],46 [A],18 [S], left precentral gyrus (e): -32 [L],1 [A],33 [S], right inferior parietal (f): 50 [R],-38 [P],39 [S], right cingulate gyrus (g): 10 [R],-3 [P],35 [S], and left superior frontal gyrus (h): -20 [L],21 [A],45 [S]. |
PMC1524763_F3_6261.jpg | What object or scene is depicted here? | The DBCS drill (Biomet Merck, Darmstadt, Germany) is used to obtain a cylindrical biopsy. The plate is still in place at that time. B Intraoperative view of the radius after drilling and plate removal. The biopsy hole has the diameter of a screw hole, so stability of the reconstructed bone is threatened in no way. |
PMC1524763_F4_6263.jpg | What is the main focus of this visual representation? | X-ray images of the hand of patient No. 5 three months after the reconstruction (4a and 4b) and after the plate removal 10 months later (4c and 4d). New bone has refilled the metaphyseal defect. |
PMC1524763_F4_6264.jpg | What can you see in this picture? | X-ray images of the hand of patient No. 5 three months after the reconstruction (4a and 4b) and after the plate removal 10 months later (4c and 4d). New bone has refilled the metaphyseal defect. |
PMC1524763_F4_6262.jpg | What is the principal component of this image? | X-ray images of the hand of patient No. 5 three months after the reconstruction (4a and 4b) and after the plate removal 10 months later (4c and 4d). New bone has refilled the metaphyseal defect. |
PMC1524763_F4_6265.jpg | What is the core subject represented in this visual? | X-ray images of the hand of patient No. 5 three months after the reconstruction (4a and 4b) and after the plate removal 10 months later (4c and 4d). New bone has refilled the metaphyseal defect. |
PMC1524771_F2_6267.jpg | Describe the main subject of this image. | Photograph of specimen from the distal ileum(left) and duodenum (right) in small organ bath containing the Krebs solution. Top: the no-load state of the intestinal segment (about 3–4 mm in length) with longitudinal image (a) and cross-sectional image (b). Bottom: the longitudinal zero-stress state was obtained by cutting the segment (a) into longitudinal strips. The bending angle φ < 180° (c) and >180° (d). |
PMC1524771_F2_6270.jpg | What is the main focus of this visual representation? | Photograph of specimen from the distal ileum(left) and duodenum (right) in small organ bath containing the Krebs solution. Top: the no-load state of the intestinal segment (about 3–4 mm in length) with longitudinal image (a) and cross-sectional image (b). Bottom: the longitudinal zero-stress state was obtained by cutting the segment (a) into longitudinal strips. The bending angle φ < 180° (c) and >180° (d). |
PMC1524771_F2_6273.jpg | What key item or scene is captured in this photo? | Photograph of specimen from the distal ileum(left) and duodenum (right) in small organ bath containing the Krebs solution. Top: the no-load state of the intestinal segment (about 3–4 mm in length) with longitudinal image (a) and cross-sectional image (b). Bottom: the longitudinal zero-stress state was obtained by cutting the segment (a) into longitudinal strips. The bending angle φ < 180° (c) and >180° (d). |
PMC1524771_F2_6271.jpg | What is shown in this image? | Photograph of specimen from the distal ileum(left) and duodenum (right) in small organ bath containing the Krebs solution. Top: the no-load state of the intestinal segment (about 3–4 mm in length) with longitudinal image (a) and cross-sectional image (b). Bottom: the longitudinal zero-stress state was obtained by cutting the segment (a) into longitudinal strips. The bending angle φ < 180° (c) and >180° (d). |
PMC1524771_F2_6269.jpg | What is being portrayed in this visual content? | Photograph of specimen from the distal ileum(left) and duodenum (right) in small organ bath containing the Krebs solution. Top: the no-load state of the intestinal segment (about 3–4 mm in length) with longitudinal image (a) and cross-sectional image (b). Bottom: the longitudinal zero-stress state was obtained by cutting the segment (a) into longitudinal strips. The bending angle φ < 180° (c) and >180° (d). |
PMC1524771_F2_6272.jpg | What is the dominant medical problem in this image? | Photograph of specimen from the distal ileum(left) and duodenum (right) in small organ bath containing the Krebs solution. Top: the no-load state of the intestinal segment (about 3–4 mm in length) with longitudinal image (a) and cross-sectional image (b). Bottom: the longitudinal zero-stress state was obtained by cutting the segment (a) into longitudinal strips. The bending angle φ < 180° (c) and >180° (d). |
PMC1524788_F1_6274.jpg | What is the central feature of this picture? | Computed chest tomography of the patient described in this report, showing bilateral interstitial infiltrates (yellow arrow) and pleural effusions (red arrow). Image taken at a mid-thoracic level. |
PMC1524794_F3_6275.jpg | What is the principal component of this image? | Representative autoradiograms of c-fos mRNA expression at different rostra-caudal levels (from top to bottom) of the striatum and adjacent cortical structures in SHR and WKY rats after vehicle or 10 mg/kg dose of SKF-81297. Coronal sections are marked "+" for anterior and "-" for posterior to bregma. STR, striatum; OT, olfactory tubercle; NAc, nucleus accumbens (shell region); AI, agranular insula cortex; Cg, cingulate cortex; Pir, piriform cortex. |
PMC1524794_F3_6277.jpg | What is being portrayed in this visual content? | Representative autoradiograms of c-fos mRNA expression at different rostra-caudal levels (from top to bottom) of the striatum and adjacent cortical structures in SHR and WKY rats after vehicle or 10 mg/kg dose of SKF-81297. Coronal sections are marked "+" for anterior and "-" for posterior to bregma. STR, striatum; OT, olfactory tubercle; NAc, nucleus accumbens (shell region); AI, agranular insula cortex; Cg, cingulate cortex; Pir, piriform cortex. |
PMC1524941_F4_6281.jpg | What is the principal component of this image? | Screenshot of the navigation system with stimulation sites of the cortical 6-contact strip electrode visualized in the 3D brain surface model. stimulation sites in green = Motor cortex/Brodman Area 4; stimulation sites in red = no motor function; CS = central sulcus. |
PMC1524941_F4_6280.jpg | What does this image primarily show? | Screenshot of the navigation system with stimulation sites of the cortical 6-contact strip electrode visualized in the 3D brain surface model. stimulation sites in green = Motor cortex/Brodman Area 4; stimulation sites in red = no motor function; CS = central sulcus. |
PMC1524941_F4_6279.jpg | What is the core subject represented in this visual? | Screenshot of the navigation system with stimulation sites of the cortical 6-contact strip electrode visualized in the 3D brain surface model. stimulation sites in green = Motor cortex/Brodman Area 4; stimulation sites in red = no motor function; CS = central sulcus. |
PMC1524949_F4_6287.jpg | What key item or scene is captured in this photo? | HPV of a partial muscular intra-acinar artery. All panels (A)-(I) refer to the same intra-acinar artery. (A) Employing phase contrast optics the cross section of an intra-acinar artery was localized in a PLCS. The vessel responded to U46619 (U) with vasoconstriction (B), which was reversed by washing the PCLS with normoxic gassed medium (flow rate 6 ml/min) and application of Nipruss. The NO donor was removed by a normoxic wash followed by exposure to normoxic gassed medium (flow rate 0.7 ml/min) (C). Perfusion with hypoxic gassed medium induced constriction of the vessel (D) which was abolished by washing the PCLS with normoxic gassed medium (E). At the end of the experiment, the viability of the artery was validated by application of U46619 (F). (I) Changes in the luminal areas are expressed as relative values, setting the luminal area at the beginning of the experiment as 100%. Time points for which original micrographs are presented in panels A-F are indicated in the curve. U = U46619; W = wash; Ni = Nipruss; No = normoxia. After completion of the videomorphometric experiment, the PLCS was stained for αSMA, and the vessel from which luminal diameters were recorded was reidentified (G, H). Conventional epifluorescence microscopy (G) of the 200 μm thick PCLS suggests the presence of a continuous αSMA-immunoreactive muscular coat, but CLSM analysis and three-dimensional reconstruction of the course of this vessel within the PCLS clearly depicts the discontinuous, spiral arrangement of αSMA-immunoreactive smooth muscle cells. Bars = 20 μm. |
PMC1524949_F4_6283.jpg | Can you identify the primary element in this image? | HPV of a partial muscular intra-acinar artery. All panels (A)-(I) refer to the same intra-acinar artery. (A) Employing phase contrast optics the cross section of an intra-acinar artery was localized in a PLCS. The vessel responded to U46619 (U) with vasoconstriction (B), which was reversed by washing the PCLS with normoxic gassed medium (flow rate 6 ml/min) and application of Nipruss. The NO donor was removed by a normoxic wash followed by exposure to normoxic gassed medium (flow rate 0.7 ml/min) (C). Perfusion with hypoxic gassed medium induced constriction of the vessel (D) which was abolished by washing the PCLS with normoxic gassed medium (E). At the end of the experiment, the viability of the artery was validated by application of U46619 (F). (I) Changes in the luminal areas are expressed as relative values, setting the luminal area at the beginning of the experiment as 100%. Time points for which original micrographs are presented in panels A-F are indicated in the curve. U = U46619; W = wash; Ni = Nipruss; No = normoxia. After completion of the videomorphometric experiment, the PLCS was stained for αSMA, and the vessel from which luminal diameters were recorded was reidentified (G, H). Conventional epifluorescence microscopy (G) of the 200 μm thick PCLS suggests the presence of a continuous αSMA-immunoreactive muscular coat, but CLSM analysis and three-dimensional reconstruction of the course of this vessel within the PCLS clearly depicts the discontinuous, spiral arrangement of αSMA-immunoreactive smooth muscle cells. Bars = 20 μm. |
PMC1524949_F4_6286.jpg | What is the main focus of this visual representation? | HPV of a partial muscular intra-acinar artery. All panels (A)-(I) refer to the same intra-acinar artery. (A) Employing phase contrast optics the cross section of an intra-acinar artery was localized in a PLCS. The vessel responded to U46619 (U) with vasoconstriction (B), which was reversed by washing the PCLS with normoxic gassed medium (flow rate 6 ml/min) and application of Nipruss. The NO donor was removed by a normoxic wash followed by exposure to normoxic gassed medium (flow rate 0.7 ml/min) (C). Perfusion with hypoxic gassed medium induced constriction of the vessel (D) which was abolished by washing the PCLS with normoxic gassed medium (E). At the end of the experiment, the viability of the artery was validated by application of U46619 (F). (I) Changes in the luminal areas are expressed as relative values, setting the luminal area at the beginning of the experiment as 100%. Time points for which original micrographs are presented in panels A-F are indicated in the curve. U = U46619; W = wash; Ni = Nipruss; No = normoxia. After completion of the videomorphometric experiment, the PLCS was stained for αSMA, and the vessel from which luminal diameters were recorded was reidentified (G, H). Conventional epifluorescence microscopy (G) of the 200 μm thick PCLS suggests the presence of a continuous αSMA-immunoreactive muscular coat, but CLSM analysis and three-dimensional reconstruction of the course of this vessel within the PCLS clearly depicts the discontinuous, spiral arrangement of αSMA-immunoreactive smooth muscle cells. Bars = 20 μm. |
PMC1524949_F4_6285.jpg | What stands out most in this visual? | HPV of a partial muscular intra-acinar artery. All panels (A)-(I) refer to the same intra-acinar artery. (A) Employing phase contrast optics the cross section of an intra-acinar artery was localized in a PLCS. The vessel responded to U46619 (U) with vasoconstriction (B), which was reversed by washing the PCLS with normoxic gassed medium (flow rate 6 ml/min) and application of Nipruss. The NO donor was removed by a normoxic wash followed by exposure to normoxic gassed medium (flow rate 0.7 ml/min) (C). Perfusion with hypoxic gassed medium induced constriction of the vessel (D) which was abolished by washing the PCLS with normoxic gassed medium (E). At the end of the experiment, the viability of the artery was validated by application of U46619 (F). (I) Changes in the luminal areas are expressed as relative values, setting the luminal area at the beginning of the experiment as 100%. Time points for which original micrographs are presented in panels A-F are indicated in the curve. U = U46619; W = wash; Ni = Nipruss; No = normoxia. After completion of the videomorphometric experiment, the PLCS was stained for αSMA, and the vessel from which luminal diameters were recorded was reidentified (G, H). Conventional epifluorescence microscopy (G) of the 200 μm thick PCLS suggests the presence of a continuous αSMA-immunoreactive muscular coat, but CLSM analysis and three-dimensional reconstruction of the course of this vessel within the PCLS clearly depicts the discontinuous, spiral arrangement of αSMA-immunoreactive smooth muscle cells. Bars = 20 μm. |
PMC1524950_F5_6293.jpg | What is the principal component of this image? | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity. The most frequent patterns (cf. also fig. 4) of immunolabelling of DiI-positive neurons (arrow) are A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+. Bar represents 50 μm throughout. |
PMC1524950_F5_6300.jpg | What is the focal point of this photograph? | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity. The most frequent patterns (cf. also fig. 4) of immunolabelling of DiI-positive neurons (arrow) are A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+. Bar represents 50 μm throughout. |
PMC1524950_F5_6291.jpg | What is the main focus of this visual representation? | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity. The most frequent patterns (cf. also fig. 4) of immunolabelling of DiI-positive neurons (arrow) are A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+. Bar represents 50 μm throughout. |
PMC1524950_F5_6295.jpg | What object or scene is depicted here? | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity. The most frequent patterns (cf. also fig. 4) of immunolabelling of DiI-positive neurons (arrow) are A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+. Bar represents 50 μm throughout. |
PMC1524950_F5_6296.jpg | What is the principal component of this image? | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity. The most frequent patterns (cf. also fig. 4) of immunolabelling of DiI-positive neurons (arrow) are A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+. Bar represents 50 μm throughout. |
PMC1524950_F5_6292.jpg | What is the focal point of this photograph? | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity. The most frequent patterns (cf. also fig. 4) of immunolabelling of DiI-positive neurons (arrow) are A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+. Bar represents 50 μm throughout. |
PMC1524950_F5_6297.jpg | What is the principal component of this image? | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity. The most frequent patterns (cf. also fig. 4) of immunolabelling of DiI-positive neurons (arrow) are A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+. Bar represents 50 μm throughout. |
PMC1524950_F5_6298.jpg | Describe the main subject of this image. | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity. The most frequent patterns (cf. also fig. 4) of immunolabelling of DiI-positive neurons (arrow) are A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+. Bar represents 50 μm throughout. |
PMC1524950_F8_6306.jpg | What's the most prominent thing you notice in this picture? | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity, showing A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+ patterns of immunoreactivity. Bar represents 50 μm throughout. |
PMC1524950_F8_6313.jpg | What does this image primarily show? | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity, showing A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+ patterns of immunoreactivity. Bar represents 50 μm throughout. |
PMC1524950_F8_6303.jpg | What key item or scene is captured in this photo? | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity, showing A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+ patterns of immunoreactivity. Bar represents 50 μm throughout. |
PMC1524950_F8_6316.jpg | What is the principal component of this image? | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity, showing A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+ patterns of immunoreactivity. Bar represents 50 μm throughout. |
PMC1524950_F8_6314.jpg | What is the principal component of this image? | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity, showing A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+ patterns of immunoreactivity. Bar represents 50 μm throughout. |
PMC1524950_F8_6308.jpg | What is the central feature of this picture? | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity, showing A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+ patterns of immunoreactivity. Bar represents 50 μm throughout. |
PMC1524950_F8_6309.jpg | What does this image primarily show? | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity, showing A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+ patterns of immunoreactivity. Bar represents 50 μm throughout. |
PMC1524950_F8_6315.jpg | What is the dominant medical problem in this image? | Quadruple-labelling (accumulation of fluorescent tracer plus triple-labelling immunohistochemistry) of DRG neurons after DiI injection into the pleural cavity, showing A) ASIC3+/TRPV1-/NF68-, B) ASIC3+/TRPV1-/NF68+, C) ASIC3+/TRPV1+/NF68-, and D) ASIC3-/TRPV1+/NF68+ patterns of immunoreactivity. Bar represents 50 μm throughout. |
PMC1524961_F2_6318.jpg | What is the core subject represented in this visual? | Magnetic resonance imaging non-contrast enhanced T-1 axial view. |
PMC1524961_F3_6319.jpg | What is the dominant medical problem in this image? | Magnetic resonance imaging contrast enhanced T-1 fat suppression sagittal view. |
PMC1524961_F4_6320.jpg | Can you identify the primary element in this image? | Computed tomography scan axial view. |
PMC1524962_F1_6321.jpg | What is the dominant medical problem in this image? | CT scan of the liver of a 34-year old man with metastases of a neuroendocrine tumour of the pancreas. Before LITT the CT scan shows a metastases of 4.7 cm in diameter in segment VII and a second metastases of 2.0 cm in diameter in segment VII subcapsular (not visible) of the liver (figure 2A). Control CT scan one week after LITT showing a coagulation lesion in segment VII of 9.0 cm in diameter and subcapsular in segment VII of 4.8 cm in diameter (figure 2B). |
PMC1524962_F1_6322.jpg | What stands out most in this visual? | CT scan of the liver of a 34-year old man with metastases of a neuroendocrine tumour of the pancreas. Before LITT the CT scan shows a metastases of 4.7 cm in diameter in segment VII and a second metastases of 2.0 cm in diameter in segment VII subcapsular (not visible) of the liver (figure 2A). Control CT scan one week after LITT showing a coagulation lesion in segment VII of 9.0 cm in diameter and subcapsular in segment VII of 4.8 cm in diameter (figure 2B). |
PMC1524978_F3_6323.jpg | What is the main focus of this visual representation? | Histologic features from FNA micro-biopsy sample showing frequent cells with Hand-Mirror morphology. Other areas in this tissue and in effusion sample showed increased proportion of eosinophils and plasma cells (H&E stain, 40 × magnification). |
PMC1524979_F1_6324.jpg | What is the core subject represented in this visual? | MGH-like pattern (ASC-H, favor reactive) Groups of metaplastic cells arranged in checkerboard like pattern. The dark nuclei may show nucleoli (arrows). (A & b- Cervical smear [Papanicolaou stained SurePath™ Preparation], c- Cervical biopsy [Hematoxylin-eosin stained section]). |
PMC1524979_F1_6326.jpg | What key item or scene is captured in this photo? | MGH-like pattern (ASC-H, favor reactive) Groups of metaplastic cells arranged in checkerboard like pattern. The dark nuclei may show nucleoli (arrows). (A & b- Cervical smear [Papanicolaou stained SurePath™ Preparation], c- Cervical biopsy [Hematoxylin-eosin stained section]). |
PMC1524982_F2_6327.jpg | Can you identify the primary element in this image? | Immunodetection of VEGF receptors expressed on the cell surface of (a-d) proliferating and (e) differentiated PC12 cells. PC12 cells were stained with polyclonal antibodies against (a) VEGFR-1, (b, e) VEGFR-2, and (c) neuropilin-1. The primary antibody was omitted in (d) controls. Differentiated PC12 cells were also immunoreactive for VEGFR-1 and neuropilin-1 (data not shown). |
PMC1524982_F2_6330.jpg | Can you identify the primary element in this image? | Immunodetection of VEGF receptors expressed on the cell surface of (a-d) proliferating and (e) differentiated PC12 cells. PC12 cells were stained with polyclonal antibodies against (a) VEGFR-1, (b, e) VEGFR-2, and (c) neuropilin-1. The primary antibody was omitted in (d) controls. Differentiated PC12 cells were also immunoreactive for VEGFR-1 and neuropilin-1 (data not shown). |
PMC1524982_F2_6329.jpg | What's the most prominent thing you notice in this picture? | Immunodetection of VEGF receptors expressed on the cell surface of (a-d) proliferating and (e) differentiated PC12 cells. PC12 cells were stained with polyclonal antibodies against (a) VEGFR-1, (b, e) VEGFR-2, and (c) neuropilin-1. The primary antibody was omitted in (d) controls. Differentiated PC12 cells were also immunoreactive for VEGFR-1 and neuropilin-1 (data not shown). |
PMC1524982_F2_6328.jpg | What is the central feature of this picture? | Immunodetection of VEGF receptors expressed on the cell surface of (a-d) proliferating and (e) differentiated PC12 cells. PC12 cells were stained with polyclonal antibodies against (a) VEGFR-1, (b, e) VEGFR-2, and (c) neuropilin-1. The primary antibody was omitted in (d) controls. Differentiated PC12 cells were also immunoreactive for VEGFR-1 and neuropilin-1 (data not shown). |
PMC1524989_F1_6333.jpg | What stands out most in this visual? | a. Photomicrograph displays a hematoxylin/eosin section (of a section of the mammary epithelial tumor at 40×). b. This same section at 200×. c. The pan-cytokeratin stain (AE1/AE3) is strongly positive, confirming the epithelial nature of the tumor. Magnification is 200×. |
PMC1524989_F1_6332.jpg | What can you see in this picture? | a. Photomicrograph displays a hematoxylin/eosin section (of a section of the mammary epithelial tumor at 40×). b. This same section at 200×. c. The pan-cytokeratin stain (AE1/AE3) is strongly positive, confirming the epithelial nature of the tumor. Magnification is 200×. |
PMC1525164_F3_6337.jpg | What is the core subject represented in this visual? | Comparison of fluorescence intensities of lines carrying insulated and uninsulated marker genes. A representative fly is shown from each of the lines carrying the insulated GMR-3xP3-AmCyan (A) and GMR-3xP3-ZsGreen (B) marker genes. Little variation in fluorescence intensity is seen between lines suggesting position effects had been minimized by the flanking scs and scs' insulator elements. In contrast lines carrying an uninsulated 3xP3-DsRed1 marker gene (C) show considerable variation in fluorescence intensity. Some lines are barely detectable above background fluorescence (y w) while other lines show very strong fluorescence. |
PMC1525164_F3_6335.jpg | What does this image primarily show? | Comparison of fluorescence intensities of lines carrying insulated and uninsulated marker genes. A representative fly is shown from each of the lines carrying the insulated GMR-3xP3-AmCyan (A) and GMR-3xP3-ZsGreen (B) marker genes. Little variation in fluorescence intensity is seen between lines suggesting position effects had been minimized by the flanking scs and scs' insulator elements. In contrast lines carrying an uninsulated 3xP3-DsRed1 marker gene (C) show considerable variation in fluorescence intensity. Some lines are barely detectable above background fluorescence (y w) while other lines show very strong fluorescence. |
PMC1525169_F15_6338.jpg | What is the central feature of this picture? | Case 50, dysplastic nevus. Less than perfect imaging contributed to confusion in this case. While all pathologists felt that the lesion was a dysplastic nevus, two pathologists could not completely rule out melanoma on H&E stains. |
PMC1525169_F16_6340.jpg | Can you identify the primary element in this image? | Case 50, dysplastic nevus. Less than perfect imaging contributed to confusion in the case. In this field, numerous epithelial melanocytes caused concern for one pathologists that that was magnified because foci were slightly out of focus (i.e. upper left corner). |
PMC1525169_F17_6341.jpg | What object or scene is depicted here? | Case 50, dysplastic nevus. Less than perfect imaging contributed to confusion in the case. This field shows dermal melanocytes that were difficult to interpret. The pathologist requested immunoperoxidase stains to evaluate the lesion further. |
PMC1525169_F18_6342.jpg | Describe the main subject of this image. | Case 57, prostate biopsy. The study pathologists disagreed about this focus. Opinions ranged from benign to suspicious to outright cancer. Special stains were non-contributory. After discussion, it was agreed that cancer could not be definitively diagnosed. This turned out to be consistent with the signed report. The area is slightly out of focus. Figure 19 shows a higher power view. |
PMC1525169_F19_6343.jpg | What is the principal component of this image? | Case 57, prostate biopsy. The study pathologists disagreed about this focus. Opinions ranged from benign to suspicious to outright cancer. Special stains were non-contributory. After discussion, it was agreed that cancer could not be definitively diagnosed. This turned out to be consistent with the signed report. The area is slightly out of focus. Figure 18 shows a lower power view. |
PMC1526585_F2_6347.jpg | What is the dominant medical problem in this image? | Double labeling for osteocalcin and tartrate-resistant acidic phosphatase for visualization of osteoblasts and osteoclasts. Paraffin-embedded sections of hind paws from arthritic mice transgenic for human tumor necrosis factor (hTNFtg) were stained by TRAP to determine osteoclasts (black arrows; purple-colored cells with three or more nuclei). In the same sections, osteoblasts were visualized by in-situ hybridization for osteocalcin (green arrows; deep blue-stained cells). (a) Overview of a representative section, original magnification × 100. (b) Close-up view of the compartment of subchondral bone erosion, original magnification × 400. (c) Cortical bone channels underneath subchondral bone erosions, original magnification × 400. (d) Inflamed endosteal bone surface distant from bone erosion, original magnification × 400. |
PMC1526585_F2_6346.jpg | What is the dominant medical problem in this image? | Double labeling for osteocalcin and tartrate-resistant acidic phosphatase for visualization of osteoblasts and osteoclasts. Paraffin-embedded sections of hind paws from arthritic mice transgenic for human tumor necrosis factor (hTNFtg) were stained by TRAP to determine osteoclasts (black arrows; purple-colored cells with three or more nuclei). In the same sections, osteoblasts were visualized by in-situ hybridization for osteocalcin (green arrows; deep blue-stained cells). (a) Overview of a representative section, original magnification × 100. (b) Close-up view of the compartment of subchondral bone erosion, original magnification × 400. (c) Cortical bone channels underneath subchondral bone erosions, original magnification × 400. (d) Inflamed endosteal bone surface distant from bone erosion, original magnification × 400. |
PMC1526585_F2_6344.jpg | Describe the main subject of this image. | Double labeling for osteocalcin and tartrate-resistant acidic phosphatase for visualization of osteoblasts and osteoclasts. Paraffin-embedded sections of hind paws from arthritic mice transgenic for human tumor necrosis factor (hTNFtg) were stained by TRAP to determine osteoclasts (black arrows; purple-colored cells with three or more nuclei). In the same sections, osteoblasts were visualized by in-situ hybridization for osteocalcin (green arrows; deep blue-stained cells). (a) Overview of a representative section, original magnification × 100. (b) Close-up view of the compartment of subchondral bone erosion, original magnification × 400. (c) Cortical bone channels underneath subchondral bone erosions, original magnification × 400. (d) Inflamed endosteal bone surface distant from bone erosion, original magnification × 400. |
PMC1526585_F2_6345.jpg | What is the dominant medical problem in this image? | Double labeling for osteocalcin and tartrate-resistant acidic phosphatase for visualization of osteoblasts and osteoclasts. Paraffin-embedded sections of hind paws from arthritic mice transgenic for human tumor necrosis factor (hTNFtg) were stained by TRAP to determine osteoclasts (black arrows; purple-colored cells with three or more nuclei). In the same sections, osteoblasts were visualized by in-situ hybridization for osteocalcin (green arrows; deep blue-stained cells). (a) Overview of a representative section, original magnification × 100. (b) Close-up view of the compartment of subchondral bone erosion, original magnification × 400. (c) Cortical bone channels underneath subchondral bone erosions, original magnification × 400. (d) Inflamed endosteal bone surface distant from bone erosion, original magnification × 400. |
PMC1526587_F3_6349.jpg | What is the principal component of this image? | Hematoxylin/eosin staining of the synovial membrane of patients 1 to 7. Original magnification × 250. Biopsy 3 (b3) of patient 2 was available only for RNA extraction and not for staining. Biopsy 3 of patient 7 was not represented in the stainings or microarray analysis because of poor RNA quality. Biopsies 1 and 4 of patient 1, and biopsy 1 of patient 4, consisted mostly of adipose cells with some element of inflammatory cells. Biopsy 1 of patient 7 had a higher level of heterogeneity, and contained more vessels, than the others. |
PMC1526587_F3_6348.jpg | What does this image primarily show? | Hematoxylin/eosin staining of the synovial membrane of patients 1 to 7. Original magnification × 250. Biopsy 3 (b3) of patient 2 was available only for RNA extraction and not for staining. Biopsy 3 of patient 7 was not represented in the stainings or microarray analysis because of poor RNA quality. Biopsies 1 and 4 of patient 1, and biopsy 1 of patient 4, consisted mostly of adipose cells with some element of inflammatory cells. Biopsy 1 of patient 7 had a higher level of heterogeneity, and contained more vessels, than the others. |
PMC1526587_F3_6351.jpg | What is the dominant medical problem in this image? | Hematoxylin/eosin staining of the synovial membrane of patients 1 to 7. Original magnification × 250. Biopsy 3 (b3) of patient 2 was available only for RNA extraction and not for staining. Biopsy 3 of patient 7 was not represented in the stainings or microarray analysis because of poor RNA quality. Biopsies 1 and 4 of patient 1, and biopsy 1 of patient 4, consisted mostly of adipose cells with some element of inflammatory cells. Biopsy 1 of patient 7 had a higher level of heterogeneity, and contained more vessels, than the others. |
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