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PMC1557841_F1_6934.jpg | What key item or scene is captured in this photo? | Preoperative CT scan. CT scan of the paranasalsinuses, demonstrating a bone density mass within the right ethmoidair cells, with well defined margins, extending laterally through thelamina papyracea, to the ipsilateral right orbit. |
PMC1557855_F1_6936.jpg | What is shown in this image? | Modified Wright's staining (100× magnification): Hypercellular marrow showing 60–70% large lymphoblasts with marked vacuolated basophilic cytoplasm, by large extent diagnostic of Lymphoblastic Lymphoma. |
PMC1557855_F2_6935.jpg | What is being portrayed in this visual content? | PAS Stain (100× magnifications): Negative. |
PMC1557857_F1_6941.jpg | What object or scene is depicted here? | Expression of hTERT protein in human urological tissue. hTERT immunostaining was localized in the nucleolus of urothelial cells. Formalin-fixed, paraffin-embedded bladder tissue biopsy (A, B) and urinary sediments (C-K) were analyzed as described in 'materials and methods' (original magnification ×200): (A), hTERT expression was generally confined to the lower half of normal colon crypts; (B, inset at higher magnification), bladder tumor biopsy, in which it can be seen that neoplastic cells and proximal, morphologically normal urothelia react with the antibody; (C), example of immunoreactive yeast present in urinary sample; (D), transitional cell carcinoma (low grade); (E), transitional cell carcinoma (high grade); (F), squamous cell carcinoma; (G), carcinoma in situ (CIS); (H), cystitis glandularis; (J), urolithiasis; (K), umbrella cells (left panel shows negative example, right panel shows an immunoreactive example). |
PMC1557857_F1_6944.jpg | Describe the main subject of this image. | Expression of hTERT protein in human urological tissue. hTERT immunostaining was localized in the nucleolus of urothelial cells. Formalin-fixed, paraffin-embedded bladder tissue biopsy (A, B) and urinary sediments (C-K) were analyzed as described in 'materials and methods' (original magnification ×200): (A), hTERT expression was generally confined to the lower half of normal colon crypts; (B, inset at higher magnification), bladder tumor biopsy, in which it can be seen that neoplastic cells and proximal, morphologically normal urothelia react with the antibody; (C), example of immunoreactive yeast present in urinary sample; (D), transitional cell carcinoma (low grade); (E), transitional cell carcinoma (high grade); (F), squamous cell carcinoma; (G), carcinoma in situ (CIS); (H), cystitis glandularis; (J), urolithiasis; (K), umbrella cells (left panel shows negative example, right panel shows an immunoreactive example). |
PMC1557857_F1_6942.jpg | What stands out most in this visual? | Expression of hTERT protein in human urological tissue. hTERT immunostaining was localized in the nucleolus of urothelial cells. Formalin-fixed, paraffin-embedded bladder tissue biopsy (A, B) and urinary sediments (C-K) were analyzed as described in 'materials and methods' (original magnification ×200): (A), hTERT expression was generally confined to the lower half of normal colon crypts; (B, inset at higher magnification), bladder tumor biopsy, in which it can be seen that neoplastic cells and proximal, morphologically normal urothelia react with the antibody; (C), example of immunoreactive yeast present in urinary sample; (D), transitional cell carcinoma (low grade); (E), transitional cell carcinoma (high grade); (F), squamous cell carcinoma; (G), carcinoma in situ (CIS); (H), cystitis glandularis; (J), urolithiasis; (K), umbrella cells (left panel shows negative example, right panel shows an immunoreactive example). |
PMC1557857_F1_6939.jpg | What is the dominant medical problem in this image? | Expression of hTERT protein in human urological tissue. hTERT immunostaining was localized in the nucleolus of urothelial cells. Formalin-fixed, paraffin-embedded bladder tissue biopsy (A, B) and urinary sediments (C-K) were analyzed as described in 'materials and methods' (original magnification ×200): (A), hTERT expression was generally confined to the lower half of normal colon crypts; (B, inset at higher magnification), bladder tumor biopsy, in which it can be seen that neoplastic cells and proximal, morphologically normal urothelia react with the antibody; (C), example of immunoreactive yeast present in urinary sample; (D), transitional cell carcinoma (low grade); (E), transitional cell carcinoma (high grade); (F), squamous cell carcinoma; (G), carcinoma in situ (CIS); (H), cystitis glandularis; (J), urolithiasis; (K), umbrella cells (left panel shows negative example, right panel shows an immunoreactive example). |
PMC1557857_F1_6937.jpg | What is the dominant medical problem in this image? | Expression of hTERT protein in human urological tissue. hTERT immunostaining was localized in the nucleolus of urothelial cells. Formalin-fixed, paraffin-embedded bladder tissue biopsy (A, B) and urinary sediments (C-K) were analyzed as described in 'materials and methods' (original magnification ×200): (A), hTERT expression was generally confined to the lower half of normal colon crypts; (B, inset at higher magnification), bladder tumor biopsy, in which it can be seen that neoplastic cells and proximal, morphologically normal urothelia react with the antibody; (C), example of immunoreactive yeast present in urinary sample; (D), transitional cell carcinoma (low grade); (E), transitional cell carcinoma (high grade); (F), squamous cell carcinoma; (G), carcinoma in situ (CIS); (H), cystitis glandularis; (J), urolithiasis; (K), umbrella cells (left panel shows negative example, right panel shows an immunoreactive example). |
PMC1557857_F1_6938.jpg | What is the central feature of this picture? | Expression of hTERT protein in human urological tissue. hTERT immunostaining was localized in the nucleolus of urothelial cells. Formalin-fixed, paraffin-embedded bladder tissue biopsy (A, B) and urinary sediments (C-K) were analyzed as described in 'materials and methods' (original magnification ×200): (A), hTERT expression was generally confined to the lower half of normal colon crypts; (B, inset at higher magnification), bladder tumor biopsy, in which it can be seen that neoplastic cells and proximal, morphologically normal urothelia react with the antibody; (C), example of immunoreactive yeast present in urinary sample; (D), transitional cell carcinoma (low grade); (E), transitional cell carcinoma (high grade); (F), squamous cell carcinoma; (G), carcinoma in situ (CIS); (H), cystitis glandularis; (J), urolithiasis; (K), umbrella cells (left panel shows negative example, right panel shows an immunoreactive example). |
PMC1557857_F1_6943.jpg | What is the core subject represented in this visual? | Expression of hTERT protein in human urological tissue. hTERT immunostaining was localized in the nucleolus of urothelial cells. Formalin-fixed, paraffin-embedded bladder tissue biopsy (A, B) and urinary sediments (C-K) were analyzed as described in 'materials and methods' (original magnification ×200): (A), hTERT expression was generally confined to the lower half of normal colon crypts; (B, inset at higher magnification), bladder tumor biopsy, in which it can be seen that neoplastic cells and proximal, morphologically normal urothelia react with the antibody; (C), example of immunoreactive yeast present in urinary sample; (D), transitional cell carcinoma (low grade); (E), transitional cell carcinoma (high grade); (F), squamous cell carcinoma; (G), carcinoma in situ (CIS); (H), cystitis glandularis; (J), urolithiasis; (K), umbrella cells (left panel shows negative example, right panel shows an immunoreactive example). |
PMC1557857_F1_6945.jpg | What's the most prominent thing you notice in this picture? | Expression of hTERT protein in human urological tissue. hTERT immunostaining was localized in the nucleolus of urothelial cells. Formalin-fixed, paraffin-embedded bladder tissue biopsy (A, B) and urinary sediments (C-K) were analyzed as described in 'materials and methods' (original magnification ×200): (A), hTERT expression was generally confined to the lower half of normal colon crypts; (B, inset at higher magnification), bladder tumor biopsy, in which it can be seen that neoplastic cells and proximal, morphologically normal urothelia react with the antibody; (C), example of immunoreactive yeast present in urinary sample; (D), transitional cell carcinoma (low grade); (E), transitional cell carcinoma (high grade); (F), squamous cell carcinoma; (G), carcinoma in situ (CIS); (H), cystitis glandularis; (J), urolithiasis; (K), umbrella cells (left panel shows negative example, right panel shows an immunoreactive example). |
PMC1559592_F6_6948.jpg | What is being portrayed in this visual content? | Nile Red staining of fat stores in wild-type, eat-3, pha-2 and pha-3 adults. L4 worms were grown on NGM plates containing the lipid-specific dye Nile Red for 24 hrs. The arrows point at the most anterior part of the intestine. (A) In wild type worms the fat granules in the intestine fluoresced brightly. In (B) eat-3 (C) pha-2 and (D) pha-3 mutants the fluorescence was markedly decreased, indicating reduced levels of fat deposits. |
PMC1559592_F6_6947.jpg | What is the dominant medical problem in this image? | Nile Red staining of fat stores in wild-type, eat-3, pha-2 and pha-3 adults. L4 worms were grown on NGM plates containing the lipid-specific dye Nile Red for 24 hrs. The arrows point at the most anterior part of the intestine. (A) In wild type worms the fat granules in the intestine fluoresced brightly. In (B) eat-3 (C) pha-2 and (D) pha-3 mutants the fluorescence was markedly decreased, indicating reduced levels of fat deposits. |
PMC1559596_F2_6953.jpg | What is the main focus of this visual representation? | Representative pictures of immunostained Aβ plaques (stained with anti-Aβ antibody) in the neocortex of (A) a 15-month-old APP/IL-1 R1+/- mouse; (B) a 15-month-old APP/IL-1 R1-/- mouse; and (C) a 15-month-old wild type Tg2576 mice (IL_1 R1+/+). (A, B, C, magnification = 100×, insert shows enlargement of Aβ plaques). |
PMC1559596_F2_6952.jpg | What does this image primarily show? | Representative pictures of immunostained Aβ plaques (stained with anti-Aβ antibody) in the neocortex of (A) a 15-month-old APP/IL-1 R1+/- mouse; (B) a 15-month-old APP/IL-1 R1-/- mouse; and (C) a 15-month-old wild type Tg2576 mice (IL_1 R1+/+). (A, B, C, magnification = 100×, insert shows enlargement of Aβ plaques). |
PMC1559612_F1_6965.jpg | What can you see in this picture? | Encapsulation of beads in Spodoptera frugiperda last instar larvae. A. Time course of encapsulation, by transmission electronic and photonic observations. a) Bead 30 minutes post-injection (p.i.). Beads are covered by an uncharacterized granular material (as described in Galleria mellonella by Schmit and Ratcliffe [115]). b) Bead 1 hour p.i. c) Bead 2 hours p.i. d) Bead 4 hours p.i. d') Detail showing desmosomes between two cells involved in the capsule. e) Bead 24 hours p.i. (phase contrast observation). B. Effect of injection of HdIV on cellular response. In a) and b) HdIV have been injected 5 hours prior to the beads, in c) HdIV and beads were injected simultaneously. a) Bead 15 hours p.i. b) Bead 6 hours p.i. c) Beads 24 hours p.i. (phase contrast observation). LB: latex bead; C: capsule; gm: granular material; des: desmosome-like junction; H: hemocyte; J: cellular junction; p: pseudopode-like extension; SB: sephadex bead; arrowheads indicate cells already partially attached to each other. The scale bar corresponds to 1 μm in all views, with exception of Figure 1d'), where the scale bar corresponds to 0.5 μm. |
PMC1559612_F1_6961.jpg | What's the most prominent thing you notice in this picture? | Encapsulation of beads in Spodoptera frugiperda last instar larvae. A. Time course of encapsulation, by transmission electronic and photonic observations. a) Bead 30 minutes post-injection (p.i.). Beads are covered by an uncharacterized granular material (as described in Galleria mellonella by Schmit and Ratcliffe [115]). b) Bead 1 hour p.i. c) Bead 2 hours p.i. d) Bead 4 hours p.i. d') Detail showing desmosomes between two cells involved in the capsule. e) Bead 24 hours p.i. (phase contrast observation). B. Effect of injection of HdIV on cellular response. In a) and b) HdIV have been injected 5 hours prior to the beads, in c) HdIV and beads were injected simultaneously. a) Bead 15 hours p.i. b) Bead 6 hours p.i. c) Beads 24 hours p.i. (phase contrast observation). LB: latex bead; C: capsule; gm: granular material; des: desmosome-like junction; H: hemocyte; J: cellular junction; p: pseudopode-like extension; SB: sephadex bead; arrowheads indicate cells already partially attached to each other. The scale bar corresponds to 1 μm in all views, with exception of Figure 1d'), where the scale bar corresponds to 0.5 μm. |
PMC1559612_F1_6959.jpg | What object or scene is depicted here? | Encapsulation of beads in Spodoptera frugiperda last instar larvae. A. Time course of encapsulation, by transmission electronic and photonic observations. a) Bead 30 minutes post-injection (p.i.). Beads are covered by an uncharacterized granular material (as described in Galleria mellonella by Schmit and Ratcliffe [115]). b) Bead 1 hour p.i. c) Bead 2 hours p.i. d) Bead 4 hours p.i. d') Detail showing desmosomes between two cells involved in the capsule. e) Bead 24 hours p.i. (phase contrast observation). B. Effect of injection of HdIV on cellular response. In a) and b) HdIV have been injected 5 hours prior to the beads, in c) HdIV and beads were injected simultaneously. a) Bead 15 hours p.i. b) Bead 6 hours p.i. c) Beads 24 hours p.i. (phase contrast observation). LB: latex bead; C: capsule; gm: granular material; des: desmosome-like junction; H: hemocyte; J: cellular junction; p: pseudopode-like extension; SB: sephadex bead; arrowheads indicate cells already partially attached to each other. The scale bar corresponds to 1 μm in all views, with exception of Figure 1d'), where the scale bar corresponds to 0.5 μm. |
PMC1559612_F1_6958.jpg | What is the principal component of this image? | Encapsulation of beads in Spodoptera frugiperda last instar larvae. A. Time course of encapsulation, by transmission electronic and photonic observations. a) Bead 30 minutes post-injection (p.i.). Beads are covered by an uncharacterized granular material (as described in Galleria mellonella by Schmit and Ratcliffe [115]). b) Bead 1 hour p.i. c) Bead 2 hours p.i. d) Bead 4 hours p.i. d') Detail showing desmosomes between two cells involved in the capsule. e) Bead 24 hours p.i. (phase contrast observation). B. Effect of injection of HdIV on cellular response. In a) and b) HdIV have been injected 5 hours prior to the beads, in c) HdIV and beads were injected simultaneously. a) Bead 15 hours p.i. b) Bead 6 hours p.i. c) Beads 24 hours p.i. (phase contrast observation). LB: latex bead; C: capsule; gm: granular material; des: desmosome-like junction; H: hemocyte; J: cellular junction; p: pseudopode-like extension; SB: sephadex bead; arrowheads indicate cells already partially attached to each other. The scale bar corresponds to 1 μm in all views, with exception of Figure 1d'), where the scale bar corresponds to 0.5 μm. |
PMC1559612_F1_6962.jpg | What is the focal point of this photograph? | Encapsulation of beads in Spodoptera frugiperda last instar larvae. A. Time course of encapsulation, by transmission electronic and photonic observations. a) Bead 30 minutes post-injection (p.i.). Beads are covered by an uncharacterized granular material (as described in Galleria mellonella by Schmit and Ratcliffe [115]). b) Bead 1 hour p.i. c) Bead 2 hours p.i. d) Bead 4 hours p.i. d') Detail showing desmosomes between two cells involved in the capsule. e) Bead 24 hours p.i. (phase contrast observation). B. Effect of injection of HdIV on cellular response. In a) and b) HdIV have been injected 5 hours prior to the beads, in c) HdIV and beads were injected simultaneously. a) Bead 15 hours p.i. b) Bead 6 hours p.i. c) Beads 24 hours p.i. (phase contrast observation). LB: latex bead; C: capsule; gm: granular material; des: desmosome-like junction; H: hemocyte; J: cellular junction; p: pseudopode-like extension; SB: sephadex bead; arrowheads indicate cells already partially attached to each other. The scale bar corresponds to 1 μm in all views, with exception of Figure 1d'), where the scale bar corresponds to 0.5 μm. |
PMC1559612_F1_6964.jpg | What stands out most in this visual? | Encapsulation of beads in Spodoptera frugiperda last instar larvae. A. Time course of encapsulation, by transmission electronic and photonic observations. a) Bead 30 minutes post-injection (p.i.). Beads are covered by an uncharacterized granular material (as described in Galleria mellonella by Schmit and Ratcliffe [115]). b) Bead 1 hour p.i. c) Bead 2 hours p.i. d) Bead 4 hours p.i. d') Detail showing desmosomes between two cells involved in the capsule. e) Bead 24 hours p.i. (phase contrast observation). B. Effect of injection of HdIV on cellular response. In a) and b) HdIV have been injected 5 hours prior to the beads, in c) HdIV and beads were injected simultaneously. a) Bead 15 hours p.i. b) Bead 6 hours p.i. c) Beads 24 hours p.i. (phase contrast observation). LB: latex bead; C: capsule; gm: granular material; des: desmosome-like junction; H: hemocyte; J: cellular junction; p: pseudopode-like extension; SB: sephadex bead; arrowheads indicate cells already partially attached to each other. The scale bar corresponds to 1 μm in all views, with exception of Figure 1d'), where the scale bar corresponds to 0.5 μm. |
PMC1559612_F2_6956.jpg | Can you identify the primary element in this image? | Infection of Spodoptera frugiperda hemocytes after infection of untreated HdIV (left panels, a and b) and heat-inactivated HdIV (right panels, c and d) by transmission electronic observations. For both control and heat treatment, HdIV particles can be observed within the cytoplasm of hemocytes (black arrows, a and c) and in vacuoles (white arrows, b and d). C: cytoplasm; N: nucleus; V: vacuole. |
PMC1559612_F2_6955.jpg | What's the most prominent thing you notice in this picture? | Infection of Spodoptera frugiperda hemocytes after infection of untreated HdIV (left panels, a and b) and heat-inactivated HdIV (right panels, c and d) by transmission electronic observations. For both control and heat treatment, HdIV particles can be observed within the cytoplasm of hemocytes (black arrows, a and c) and in vacuoles (white arrows, b and d). C: cytoplasm; N: nucleus; V: vacuole. |
PMC1559612_F2_6954.jpg | What is the dominant medical problem in this image? | Infection of Spodoptera frugiperda hemocytes after infection of untreated HdIV (left panels, a and b) and heat-inactivated HdIV (right panels, c and d) by transmission electronic observations. For both control and heat treatment, HdIV particles can be observed within the cytoplasm of hemocytes (black arrows, a and c) and in vacuoles (white arrows, b and d). C: cytoplasm; N: nucleus; V: vacuole. |
PMC1559612_F2_6957.jpg | Describe the main subject of this image. | Infection of Spodoptera frugiperda hemocytes after infection of untreated HdIV (left panels, a and b) and heat-inactivated HdIV (right panels, c and d) by transmission electronic observations. For both control and heat treatment, HdIV particles can be observed within the cytoplasm of hemocytes (black arrows, a and c) and in vacuoles (white arrows, b and d). C: cytoplasm; N: nucleus; V: vacuole. |
PMC1559623_F4_6970.jpg | What is the dominant medical problem in this image? | The phosphatase activity null PTEN leads to formation of visible tau aggregates in cells. COS-7 cells stably expressing the FTDP-17 mutant tau were transfected with pIRES-EGFP (A-D), pIRES-EGFP-PTENwt (E-H) or pIRES-EGFP-PTENcg (I-L). Expression of EGFP control (A), PTEN-WT (E) or PTEN-CG (I) was visualized based on the EGFP fluorescence. Cells were further immunostained to detect tau (B,F,J) and α-tubulin (C,G,K). Fluorescence micrographs were visualized and recorded by fluorescence microscope. D, H, and L are merged images of tau and α-tubulin immunostaining. |
PMC1559623_F4_6972.jpg | What is the dominant medical problem in this image? | The phosphatase activity null PTEN leads to formation of visible tau aggregates in cells. COS-7 cells stably expressing the FTDP-17 mutant tau were transfected with pIRES-EGFP (A-D), pIRES-EGFP-PTENwt (E-H) or pIRES-EGFP-PTENcg (I-L). Expression of EGFP control (A), PTEN-WT (E) or PTEN-CG (I) was visualized based on the EGFP fluorescence. Cells were further immunostained to detect tau (B,F,J) and α-tubulin (C,G,K). Fluorescence micrographs were visualized and recorded by fluorescence microscope. D, H, and L are merged images of tau and α-tubulin immunostaining. |
PMC1559623_F4_6980.jpg | What's the most prominent thing you notice in this picture? | The phosphatase activity null PTEN leads to formation of visible tau aggregates in cells. COS-7 cells stably expressing the FTDP-17 mutant tau were transfected with pIRES-EGFP (A-D), pIRES-EGFP-PTENwt (E-H) or pIRES-EGFP-PTENcg (I-L). Expression of EGFP control (A), PTEN-WT (E) or PTEN-CG (I) was visualized based on the EGFP fluorescence. Cells were further immunostained to detect tau (B,F,J) and α-tubulin (C,G,K). Fluorescence micrographs were visualized and recorded by fluorescence microscope. D, H, and L are merged images of tau and α-tubulin immunostaining. |
PMC1559623_F4_6979.jpg | What is the principal component of this image? | The phosphatase activity null PTEN leads to formation of visible tau aggregates in cells. COS-7 cells stably expressing the FTDP-17 mutant tau were transfected with pIRES-EGFP (A-D), pIRES-EGFP-PTENwt (E-H) or pIRES-EGFP-PTENcg (I-L). Expression of EGFP control (A), PTEN-WT (E) or PTEN-CG (I) was visualized based on the EGFP fluorescence. Cells were further immunostained to detect tau (B,F,J) and α-tubulin (C,G,K). Fluorescence micrographs were visualized and recorded by fluorescence microscope. D, H, and L are merged images of tau and α-tubulin immunostaining. |
PMC1559623_F4_6977.jpg | Can you identify the primary element in this image? | The phosphatase activity null PTEN leads to formation of visible tau aggregates in cells. COS-7 cells stably expressing the FTDP-17 mutant tau were transfected with pIRES-EGFP (A-D), pIRES-EGFP-PTENwt (E-H) or pIRES-EGFP-PTENcg (I-L). Expression of EGFP control (A), PTEN-WT (E) or PTEN-CG (I) was visualized based on the EGFP fluorescence. Cells were further immunostained to detect tau (B,F,J) and α-tubulin (C,G,K). Fluorescence micrographs were visualized and recorded by fluorescence microscope. D, H, and L are merged images of tau and α-tubulin immunostaining. |
PMC1559623_F4_6978.jpg | What key item or scene is captured in this photo? | The phosphatase activity null PTEN leads to formation of visible tau aggregates in cells. COS-7 cells stably expressing the FTDP-17 mutant tau were transfected with pIRES-EGFP (A-D), pIRES-EGFP-PTENwt (E-H) or pIRES-EGFP-PTENcg (I-L). Expression of EGFP control (A), PTEN-WT (E) or PTEN-CG (I) was visualized based on the EGFP fluorescence. Cells were further immunostained to detect tau (B,F,J) and α-tubulin (C,G,K). Fluorescence micrographs were visualized and recorded by fluorescence microscope. D, H, and L are merged images of tau and α-tubulin immunostaining. |
PMC1559623_F4_6975.jpg | What is the main focus of this visual representation? | The phosphatase activity null PTEN leads to formation of visible tau aggregates in cells. COS-7 cells stably expressing the FTDP-17 mutant tau were transfected with pIRES-EGFP (A-D), pIRES-EGFP-PTENwt (E-H) or pIRES-EGFP-PTENcg (I-L). Expression of EGFP control (A), PTEN-WT (E) or PTEN-CG (I) was visualized based on the EGFP fluorescence. Cells were further immunostained to detect tau (B,F,J) and α-tubulin (C,G,K). Fluorescence micrographs were visualized and recorded by fluorescence microscope. D, H, and L are merged images of tau and α-tubulin immunostaining. |
PMC1559625_F1_6967.jpg | What is the focal point of this photograph? | Hemophagocytosis in lymph nodes from a patient with HME (left) and RMSF (right) (H&E; original magnification 240×). |
PMC1559625_F2_6968.jpg | Can you identify the primary element in this image? | Lymph node cellularity in a patient with HME (left) and RMSF (right) (H&E; original magnification 64×). |
PMC1559625_F3_6987.jpg | What is shown in this image? | Immunophenotypic changes in lymph nodes from patients with HME. Note the marked expansion of CD8 cells in the medullary and paracortical regions (a) not observed in the control lymph node from a patient with bacterial bronchopneumonia (b). Although not quantitatively different, CD68 macrophages were more clustered within the medullary sinuses and paracortical regions in lymph nodes from HME patients (c) compared with the marginal distribution observed in a control lymph node from a patient with bacterial bronchopneumonia (d) (Immunoperoxidase with hematoxylin counterstain; original magnifications 20×). |
PMC1559625_F3_6985.jpg | What is the dominant medical problem in this image? | Immunophenotypic changes in lymph nodes from patients with HME. Note the marked expansion of CD8 cells in the medullary and paracortical regions (a) not observed in the control lymph node from a patient with bacterial bronchopneumonia (b). Although not quantitatively different, CD68 macrophages were more clustered within the medullary sinuses and paracortical regions in lymph nodes from HME patients (c) compared with the marginal distribution observed in a control lymph node from a patient with bacterial bronchopneumonia (d) (Immunoperoxidase with hematoxylin counterstain; original magnifications 20×). |
PMC1559625_F3_6986.jpg | What is the principal component of this image? | Immunophenotypic changes in lymph nodes from patients with HME. Note the marked expansion of CD8 cells in the medullary and paracortical regions (a) not observed in the control lymph node from a patient with bacterial bronchopneumonia (b). Although not quantitatively different, CD68 macrophages were more clustered within the medullary sinuses and paracortical regions in lymph nodes from HME patients (c) compared with the marginal distribution observed in a control lymph node from a patient with bacterial bronchopneumonia (d) (Immunoperoxidase with hematoxylin counterstain; original magnifications 20×). |
PMC1559625_F3_6984.jpg | Can you identify the primary element in this image? | Immunophenotypic changes in lymph nodes from patients with HME. Note the marked expansion of CD8 cells in the medullary and paracortical regions (a) not observed in the control lymph node from a patient with bacterial bronchopneumonia (b). Although not quantitatively different, CD68 macrophages were more clustered within the medullary sinuses and paracortical regions in lymph nodes from HME patients (c) compared with the marginal distribution observed in a control lymph node from a patient with bacterial bronchopneumonia (d) (Immunoperoxidase with hematoxylin counterstain; original magnifications 20×). |
PMC1559625_F4_6983.jpg | What is the core subject represented in this visual? | Immunohistochemical demonstration of typical bacterial burden in lymph nodes from patients with HME (left) and RMSF (right) (immunoperoxidase with hematoxylin counterstain; original magnification 240×). |
PMC1559630_F1_6991.jpg | What is the dominant medical problem in this image? | Nontypeable Haemophilus influenzae biofilm imaged via scanning electron microscopy. Scanning electron micrographs of NTHi biofilms formed under different growth conditions. A and B) Sterile glass coverslips were covered with a suspension of NTHi in BHI broth. After 24 hr, the coverslips were prepared for SEM examination. (A) Large flat mats of bacteria embedded in an amorphous extracellular matrix were found attached to the glass surface. Scale bar = 2 μm. (B) The individual NTHi are covered in an amorphous layer that conceals the bacterial surface. Scale bar = 1 μm. C and D) Suspensions of NTHi in BHI broth were placed onto sterile Anopore insert filters that were mounted on chocolate agar. Once the NTHi biofilms had formed, after 24 hr incubation, on the upper surface of the filters at the air/liquid interface, the inserts were placed in culture dishes containing sufficient sterile culture medium to exert a positive upward pressure on the bottom of the biofilm, and left for a subsequent 24 hr. (C) The surface of the insert filter is covered with a flat mat consisting of NTHi closely attached to each other. Channels and pockets freee of bacteria have formed within the mat of bacteria. Scale bar = 2 μm. (D) In some orientations, it is possible to see the channels running between the aggregates of bacteria and through the mat. Scale bar = 2 μm. E and F) NTHi biofilms grown on Millipore filters. Sterile Millipore filters were placed onto chocolate agar plates and inoculated with sufficient NTHi in BHI broth to cover the surface at a density of 0.3 bacteria per 10 μmP2P. The filters were incubated for 24 hr with the upper surface exposed to air, and prepared for SEM examination. (E) The NTHi formed thick biofilms with the base firmly attached to the filter substrate. Scale bar = 2 μm. (F) The top surface of the NTHi biofilm, that had been exposed to air, was covered with a thin film of extracellular matrix. In some instances, the matrix formed a film over regions that resembled bacteria-free pockets. Scale bar = 2 μm. |
PMC1559630_F1_6990.jpg | What's the most prominent thing you notice in this picture? | Nontypeable Haemophilus influenzae biofilm imaged via scanning electron microscopy. Scanning electron micrographs of NTHi biofilms formed under different growth conditions. A and B) Sterile glass coverslips were covered with a suspension of NTHi in BHI broth. After 24 hr, the coverslips were prepared for SEM examination. (A) Large flat mats of bacteria embedded in an amorphous extracellular matrix were found attached to the glass surface. Scale bar = 2 μm. (B) The individual NTHi are covered in an amorphous layer that conceals the bacterial surface. Scale bar = 1 μm. C and D) Suspensions of NTHi in BHI broth were placed onto sterile Anopore insert filters that were mounted on chocolate agar. Once the NTHi biofilms had formed, after 24 hr incubation, on the upper surface of the filters at the air/liquid interface, the inserts were placed in culture dishes containing sufficient sterile culture medium to exert a positive upward pressure on the bottom of the biofilm, and left for a subsequent 24 hr. (C) The surface of the insert filter is covered with a flat mat consisting of NTHi closely attached to each other. Channels and pockets freee of bacteria have formed within the mat of bacteria. Scale bar = 2 μm. (D) In some orientations, it is possible to see the channels running between the aggregates of bacteria and through the mat. Scale bar = 2 μm. E and F) NTHi biofilms grown on Millipore filters. Sterile Millipore filters were placed onto chocolate agar plates and inoculated with sufficient NTHi in BHI broth to cover the surface at a density of 0.3 bacteria per 10 μmP2P. The filters were incubated for 24 hr with the upper surface exposed to air, and prepared for SEM examination. (E) The NTHi formed thick biofilms with the base firmly attached to the filter substrate. Scale bar = 2 μm. (F) The top surface of the NTHi biofilm, that had been exposed to air, was covered with a thin film of extracellular matrix. In some instances, the matrix formed a film over regions that resembled bacteria-free pockets. Scale bar = 2 μm. |
PMC1559630_F1_6988.jpg | What object or scene is depicted here? | Nontypeable Haemophilus influenzae biofilm imaged via scanning electron microscopy. Scanning electron micrographs of NTHi biofilms formed under different growth conditions. A and B) Sterile glass coverslips were covered with a suspension of NTHi in BHI broth. After 24 hr, the coverslips were prepared for SEM examination. (A) Large flat mats of bacteria embedded in an amorphous extracellular matrix were found attached to the glass surface. Scale bar = 2 μm. (B) The individual NTHi are covered in an amorphous layer that conceals the bacterial surface. Scale bar = 1 μm. C and D) Suspensions of NTHi in BHI broth were placed onto sterile Anopore insert filters that were mounted on chocolate agar. Once the NTHi biofilms had formed, after 24 hr incubation, on the upper surface of the filters at the air/liquid interface, the inserts were placed in culture dishes containing sufficient sterile culture medium to exert a positive upward pressure on the bottom of the biofilm, and left for a subsequent 24 hr. (C) The surface of the insert filter is covered with a flat mat consisting of NTHi closely attached to each other. Channels and pockets freee of bacteria have formed within the mat of bacteria. Scale bar = 2 μm. (D) In some orientations, it is possible to see the channels running between the aggregates of bacteria and through the mat. Scale bar = 2 μm. E and F) NTHi biofilms grown on Millipore filters. Sterile Millipore filters were placed onto chocolate agar plates and inoculated with sufficient NTHi in BHI broth to cover the surface at a density of 0.3 bacteria per 10 μmP2P. The filters were incubated for 24 hr with the upper surface exposed to air, and prepared for SEM examination. (E) The NTHi formed thick biofilms with the base firmly attached to the filter substrate. Scale bar = 2 μm. (F) The top surface of the NTHi biofilm, that had been exposed to air, was covered with a thin film of extracellular matrix. In some instances, the matrix formed a film over regions that resembled bacteria-free pockets. Scale bar = 2 μm. |
PMC1559630_F1_6993.jpg | What is the core subject represented in this visual? | Nontypeable Haemophilus influenzae biofilm imaged via scanning electron microscopy. Scanning electron micrographs of NTHi biofilms formed under different growth conditions. A and B) Sterile glass coverslips were covered with a suspension of NTHi in BHI broth. After 24 hr, the coverslips were prepared for SEM examination. (A) Large flat mats of bacteria embedded in an amorphous extracellular matrix were found attached to the glass surface. Scale bar = 2 μm. (B) The individual NTHi are covered in an amorphous layer that conceals the bacterial surface. Scale bar = 1 μm. C and D) Suspensions of NTHi in BHI broth were placed onto sterile Anopore insert filters that were mounted on chocolate agar. Once the NTHi biofilms had formed, after 24 hr incubation, on the upper surface of the filters at the air/liquid interface, the inserts were placed in culture dishes containing sufficient sterile culture medium to exert a positive upward pressure on the bottom of the biofilm, and left for a subsequent 24 hr. (C) The surface of the insert filter is covered with a flat mat consisting of NTHi closely attached to each other. Channels and pockets freee of bacteria have formed within the mat of bacteria. Scale bar = 2 μm. (D) In some orientations, it is possible to see the channels running between the aggregates of bacteria and through the mat. Scale bar = 2 μm. E and F) NTHi biofilms grown on Millipore filters. Sterile Millipore filters were placed onto chocolate agar plates and inoculated with sufficient NTHi in BHI broth to cover the surface at a density of 0.3 bacteria per 10 μmP2P. The filters were incubated for 24 hr with the upper surface exposed to air, and prepared for SEM examination. (E) The NTHi formed thick biofilms with the base firmly attached to the filter substrate. Scale bar = 2 μm. (F) The top surface of the NTHi biofilm, that had been exposed to air, was covered with a thin film of extracellular matrix. In some instances, the matrix formed a film over regions that resembled bacteria-free pockets. Scale bar = 2 μm. |
PMC1559630_F1_6989.jpg | What is the central feature of this picture? | Nontypeable Haemophilus influenzae biofilm imaged via scanning electron microscopy. Scanning electron micrographs of NTHi biofilms formed under different growth conditions. A and B) Sterile glass coverslips were covered with a suspension of NTHi in BHI broth. After 24 hr, the coverslips were prepared for SEM examination. (A) Large flat mats of bacteria embedded in an amorphous extracellular matrix were found attached to the glass surface. Scale bar = 2 μm. (B) The individual NTHi are covered in an amorphous layer that conceals the bacterial surface. Scale bar = 1 μm. C and D) Suspensions of NTHi in BHI broth were placed onto sterile Anopore insert filters that were mounted on chocolate agar. Once the NTHi biofilms had formed, after 24 hr incubation, on the upper surface of the filters at the air/liquid interface, the inserts were placed in culture dishes containing sufficient sterile culture medium to exert a positive upward pressure on the bottom of the biofilm, and left for a subsequent 24 hr. (C) The surface of the insert filter is covered with a flat mat consisting of NTHi closely attached to each other. Channels and pockets freee of bacteria have formed within the mat of bacteria. Scale bar = 2 μm. (D) In some orientations, it is possible to see the channels running between the aggregates of bacteria and through the mat. Scale bar = 2 μm. E and F) NTHi biofilms grown on Millipore filters. Sterile Millipore filters were placed onto chocolate agar plates and inoculated with sufficient NTHi in BHI broth to cover the surface at a density of 0.3 bacteria per 10 μmP2P. The filters were incubated for 24 hr with the upper surface exposed to air, and prepared for SEM examination. (E) The NTHi formed thick biofilms with the base firmly attached to the filter substrate. Scale bar = 2 μm. (F) The top surface of the NTHi biofilm, that had been exposed to air, was covered with a thin film of extracellular matrix. In some instances, the matrix formed a film over regions that resembled bacteria-free pockets. Scale bar = 2 μm. |
PMC1559640_F3_6997.jpg | Describe the main subject of this image. | Radiological history of the patient. From left (x-ray taken outside our centre before start of treatment) to right the radiological course of the patient can be seen (last picture after 27 months on the right). A progression of the curve is visible. |
PMC1559640_F3_7000.jpg | What stands out most in this visual? | Radiological history of the patient. From left (x-ray taken outside our centre before start of treatment) to right the radiological course of the patient can be seen (last picture after 27 months on the right). A progression of the curve is visible. |
PMC1559640_F3_6999.jpg | What is the central feature of this picture? | Radiological history of the patient. From left (x-ray taken outside our centre before start of treatment) to right the radiological course of the patient can be seen (last picture after 27 months on the right). A progression of the curve is visible. |
PMC1559640_F3_6998.jpg | What stands out most in this visual? | Radiological history of the patient. From left (x-ray taken outside our centre before start of treatment) to right the radiological course of the patient can be seen (last picture after 27 months on the right). A progression of the curve is visible. |
PMC1559682_F2_7014.jpg | Describe the main subject of this image. | Alterations of the pancreas from Ela-myc transgenic mice. A: a photo showing a huge nodular pancreatic tumor (arrows). Note that one tumor nodule is in red color while other tumor nodules are in white color. B: liver metastases (arrows) of a pancreatic tumor. C: histological examination confirming that the liver tumors are pancreatic origin (acinar cell carcinoma). D: a typical histology of acinar cell carcinoma that shows red color macroscopically. E: a typical histology of the acinar cell carcinoma that shows white color macroscopically. Note that there are many apoptotic cells that are organized in clusters, coined as "death cell islands" (arrows). F: a typical area of mixed acinar and ductal adenocarcinomas. G: a pancreatic ductal adenocarcinoma. Note that the tumor contains abundant stroma. H: another typical ductal adenocarcinoma. I: an acinar cell carcinoma within an islet (arrow). |
PMC1559682_F2_7012.jpg | What is the dominant medical problem in this image? | Alterations of the pancreas from Ela-myc transgenic mice. A: a photo showing a huge nodular pancreatic tumor (arrows). Note that one tumor nodule is in red color while other tumor nodules are in white color. B: liver metastases (arrows) of a pancreatic tumor. C: histological examination confirming that the liver tumors are pancreatic origin (acinar cell carcinoma). D: a typical histology of acinar cell carcinoma that shows red color macroscopically. E: a typical histology of the acinar cell carcinoma that shows white color macroscopically. Note that there are many apoptotic cells that are organized in clusters, coined as "death cell islands" (arrows). F: a typical area of mixed acinar and ductal adenocarcinomas. G: a pancreatic ductal adenocarcinoma. Note that the tumor contains abundant stroma. H: another typical ductal adenocarcinoma. I: an acinar cell carcinoma within an islet (arrow). |
PMC1559682_F2_7015.jpg | What can you see in this picture? | Alterations of the pancreas from Ela-myc transgenic mice. A: a photo showing a huge nodular pancreatic tumor (arrows). Note that one tumor nodule is in red color while other tumor nodules are in white color. B: liver metastases (arrows) of a pancreatic tumor. C: histological examination confirming that the liver tumors are pancreatic origin (acinar cell carcinoma). D: a typical histology of acinar cell carcinoma that shows red color macroscopically. E: a typical histology of the acinar cell carcinoma that shows white color macroscopically. Note that there are many apoptotic cells that are organized in clusters, coined as "death cell islands" (arrows). F: a typical area of mixed acinar and ductal adenocarcinomas. G: a pancreatic ductal adenocarcinoma. Note that the tumor contains abundant stroma. H: another typical ductal adenocarcinoma. I: an acinar cell carcinoma within an islet (arrow). |
PMC1559682_F2_7011.jpg | What is shown in this image? | Alterations of the pancreas from Ela-myc transgenic mice. A: a photo showing a huge nodular pancreatic tumor (arrows). Note that one tumor nodule is in red color while other tumor nodules are in white color. B: liver metastases (arrows) of a pancreatic tumor. C: histological examination confirming that the liver tumors are pancreatic origin (acinar cell carcinoma). D: a typical histology of acinar cell carcinoma that shows red color macroscopically. E: a typical histology of the acinar cell carcinoma that shows white color macroscopically. Note that there are many apoptotic cells that are organized in clusters, coined as "death cell islands" (arrows). F: a typical area of mixed acinar and ductal adenocarcinomas. G: a pancreatic ductal adenocarcinoma. Note that the tumor contains abundant stroma. H: another typical ductal adenocarcinoma. I: an acinar cell carcinoma within an islet (arrow). |
PMC1559682_F2_7009.jpg | What object or scene is depicted here? | Alterations of the pancreas from Ela-myc transgenic mice. A: a photo showing a huge nodular pancreatic tumor (arrows). Note that one tumor nodule is in red color while other tumor nodules are in white color. B: liver metastases (arrows) of a pancreatic tumor. C: histological examination confirming that the liver tumors are pancreatic origin (acinar cell carcinoma). D: a typical histology of acinar cell carcinoma that shows red color macroscopically. E: a typical histology of the acinar cell carcinoma that shows white color macroscopically. Note that there are many apoptotic cells that are organized in clusters, coined as "death cell islands" (arrows). F: a typical area of mixed acinar and ductal adenocarcinomas. G: a pancreatic ductal adenocarcinoma. Note that the tumor contains abundant stroma. H: another typical ductal adenocarcinoma. I: an acinar cell carcinoma within an islet (arrow). |
PMC1559682_F2_7010.jpg | What is the central feature of this picture? | Alterations of the pancreas from Ela-myc transgenic mice. A: a photo showing a huge nodular pancreatic tumor (arrows). Note that one tumor nodule is in red color while other tumor nodules are in white color. B: liver metastases (arrows) of a pancreatic tumor. C: histological examination confirming that the liver tumors are pancreatic origin (acinar cell carcinoma). D: a typical histology of acinar cell carcinoma that shows red color macroscopically. E: a typical histology of the acinar cell carcinoma that shows white color macroscopically. Note that there are many apoptotic cells that are organized in clusters, coined as "death cell islands" (arrows). F: a typical area of mixed acinar and ductal adenocarcinomas. G: a pancreatic ductal adenocarcinoma. Note that the tumor contains abundant stroma. H: another typical ductal adenocarcinoma. I: an acinar cell carcinoma within an islet (arrow). |
PMC1559682_F2_7007.jpg | What is shown in this image? | Alterations of the pancreas from Ela-myc transgenic mice. A: a photo showing a huge nodular pancreatic tumor (arrows). Note that one tumor nodule is in red color while other tumor nodules are in white color. B: liver metastases (arrows) of a pancreatic tumor. C: histological examination confirming that the liver tumors are pancreatic origin (acinar cell carcinoma). D: a typical histology of acinar cell carcinoma that shows red color macroscopically. E: a typical histology of the acinar cell carcinoma that shows white color macroscopically. Note that there are many apoptotic cells that are organized in clusters, coined as "death cell islands" (arrows). F: a typical area of mixed acinar and ductal adenocarcinomas. G: a pancreatic ductal adenocarcinoma. Note that the tumor contains abundant stroma. H: another typical ductal adenocarcinoma. I: an acinar cell carcinoma within an islet (arrow). |
PMC1559682_F2_7008.jpg | What is the dominant medical problem in this image? | Alterations of the pancreas from Ela-myc transgenic mice. A: a photo showing a huge nodular pancreatic tumor (arrows). Note that one tumor nodule is in red color while other tumor nodules are in white color. B: liver metastases (arrows) of a pancreatic tumor. C: histological examination confirming that the liver tumors are pancreatic origin (acinar cell carcinoma). D: a typical histology of acinar cell carcinoma that shows red color macroscopically. E: a typical histology of the acinar cell carcinoma that shows white color macroscopically. Note that there are many apoptotic cells that are organized in clusters, coined as "death cell islands" (arrows). F: a typical area of mixed acinar and ductal adenocarcinomas. G: a pancreatic ductal adenocarcinoma. Note that the tumor contains abundant stroma. H: another typical ductal adenocarcinoma. I: an acinar cell carcinoma within an islet (arrow). |
PMC1559682_F2_7013.jpg | What's the most prominent thing you notice in this picture? | Alterations of the pancreas from Ela-myc transgenic mice. A: a photo showing a huge nodular pancreatic tumor (arrows). Note that one tumor nodule is in red color while other tumor nodules are in white color. B: liver metastases (arrows) of a pancreatic tumor. C: histological examination confirming that the liver tumors are pancreatic origin (acinar cell carcinoma). D: a typical histology of acinar cell carcinoma that shows red color macroscopically. E: a typical histology of the acinar cell carcinoma that shows white color macroscopically. Note that there are many apoptotic cells that are organized in clusters, coined as "death cell islands" (arrows). F: a typical area of mixed acinar and ductal adenocarcinomas. G: a pancreatic ductal adenocarcinoma. Note that the tumor contains abundant stroma. H: another typical ductal adenocarcinoma. I: an acinar cell carcinoma within an islet (arrow). |
PMC1559682_F4_7006.jpg | Can you identify the primary element in this image? | Immunohistochemical staining for c-Myc and TGFα in human pancreatic ductal adenocarcinomas. 4A, 4B and 4C: c-Myc staining showing that most tumor cells manifest positive nuclear staining. 4D and 4E: TGFα staining showing most tumor cells are positive for TGFα. Note that the staining is mainly localized in the cytoplasm of most tumor cells, but it is also localized in the nucleus (arrows) of some tumor cells. 4F: a "normal" area of pancreatic tissue adjacent to cancer, showing that ductal cells (arrows), but not acinar cells, are positive for TGFα. |
PMC1559682_F4_7004.jpg | What object or scene is depicted here? | Immunohistochemical staining for c-Myc and TGFα in human pancreatic ductal adenocarcinomas. 4A, 4B and 4C: c-Myc staining showing that most tumor cells manifest positive nuclear staining. 4D and 4E: TGFα staining showing most tumor cells are positive for TGFα. Note that the staining is mainly localized in the cytoplasm of most tumor cells, but it is also localized in the nucleus (arrows) of some tumor cells. 4F: a "normal" area of pancreatic tissue adjacent to cancer, showing that ductal cells (arrows), but not acinar cells, are positive for TGFα. |
PMC1559682_F4_7005.jpg | What key item or scene is captured in this photo? | Immunohistochemical staining for c-Myc and TGFα in human pancreatic ductal adenocarcinomas. 4A, 4B and 4C: c-Myc staining showing that most tumor cells manifest positive nuclear staining. 4D and 4E: TGFα staining showing most tumor cells are positive for TGFα. Note that the staining is mainly localized in the cytoplasm of most tumor cells, but it is also localized in the nucleus (arrows) of some tumor cells. 4F: a "normal" area of pancreatic tissue adjacent to cancer, showing that ductal cells (arrows), but not acinar cells, are positive for TGFα. |
PMC1559682_F4_7002.jpg | What key item or scene is captured in this photo? | Immunohistochemical staining for c-Myc and TGFα in human pancreatic ductal adenocarcinomas. 4A, 4B and 4C: c-Myc staining showing that most tumor cells manifest positive nuclear staining. 4D and 4E: TGFα staining showing most tumor cells are positive for TGFα. Note that the staining is mainly localized in the cytoplasm of most tumor cells, but it is also localized in the nucleus (arrows) of some tumor cells. 4F: a "normal" area of pancreatic tissue adjacent to cancer, showing that ductal cells (arrows), but not acinar cells, are positive for TGFα. |
PMC1559682_F4_7001.jpg | What stands out most in this visual? | Immunohistochemical staining for c-Myc and TGFα in human pancreatic ductal adenocarcinomas. 4A, 4B and 4C: c-Myc staining showing that most tumor cells manifest positive nuclear staining. 4D and 4E: TGFα staining showing most tumor cells are positive for TGFα. Note that the staining is mainly localized in the cytoplasm of most tumor cells, but it is also localized in the nucleus (arrows) of some tumor cells. 4F: a "normal" area of pancreatic tissue adjacent to cancer, showing that ductal cells (arrows), but not acinar cells, are positive for TGFα. |
PMC1559723_F2_7018.jpg | What stands out most in this visual? | Mammary gland morphology during the development. (a) Analysis of carmine-stained whole mounts (magnification 6×) and (b) hemotoxylin and eosin (H&E)-stained sections (magnification 100×) showing the relative changes in size of the epithelial and adipose compartments of the number 4 mammary gland at the indicated time points during mammary gland development. |
PMC1559723_F2_7022.jpg | What is the principal component of this image? | Mammary gland morphology during the development. (a) Analysis of carmine-stained whole mounts (magnification 6×) and (b) hemotoxylin and eosin (H&E)-stained sections (magnification 100×) showing the relative changes in size of the epithelial and adipose compartments of the number 4 mammary gland at the indicated time points during mammary gland development. |
PMC1559723_F2_7019.jpg | Can you identify the primary element in this image? | Mammary gland morphology during the development. (a) Analysis of carmine-stained whole mounts (magnification 6×) and (b) hemotoxylin and eosin (H&E)-stained sections (magnification 100×) showing the relative changes in size of the epithelial and adipose compartments of the number 4 mammary gland at the indicated time points during mammary gland development. |
PMC1559723_F2_7016.jpg | What is the dominant medical problem in this image? | Mammary gland morphology during the development. (a) Analysis of carmine-stained whole mounts (magnification 6×) and (b) hemotoxylin and eosin (H&E)-stained sections (magnification 100×) showing the relative changes in size of the epithelial and adipose compartments of the number 4 mammary gland at the indicated time points during mammary gland development. |
PMC1559723_F2_7020.jpg | What key item or scene is captured in this photo? | Mammary gland morphology during the development. (a) Analysis of carmine-stained whole mounts (magnification 6×) and (b) hemotoxylin and eosin (H&E)-stained sections (magnification 100×) showing the relative changes in size of the epithelial and adipose compartments of the number 4 mammary gland at the indicated time points during mammary gland development. |
PMC1559723_F2_7021.jpg | What is the dominant medical problem in this image? | Mammary gland morphology during the development. (a) Analysis of carmine-stained whole mounts (magnification 6×) and (b) hemotoxylin and eosin (H&E)-stained sections (magnification 100×) showing the relative changes in size of the epithelial and adipose compartments of the number 4 mammary gland at the indicated time points during mammary gland development. |
PMC1559723_F2_7017.jpg | What's the most prominent thing you notice in this picture? | Mammary gland morphology during the development. (a) Analysis of carmine-stained whole mounts (magnification 6×) and (b) hemotoxylin and eosin (H&E)-stained sections (magnification 100×) showing the relative changes in size of the epithelial and adipose compartments of the number 4 mammary gland at the indicated time points during mammary gland development. |
PMC1560153_F1_7023.jpg | What is being portrayed in this visual content? | Computerised Tomography of abdomen on admission. |
PMC1560372_F3_7026.jpg | What's the most prominent thing you notice in this picture? | Direct selection of Pc 23–231-GFP mutants with increased fluorescence. Fluorescence of the three prion mutants (17, 22 and 25) isolated by the procedures described. Each was grown overnight on agar plates and a heavy inoculum transferred to a sectored agar plate supplemented with IPTG to induce expression of the fusion protein. After three hours at 37 degrees the plate was photographed under UV light. |
PMC1560372_F3_7027.jpg | What key item or scene is captured in this photo? | Direct selection of Pc 23–231-GFP mutants with increased fluorescence. Fluorescence of the three prion mutants (17, 22 and 25) isolated by the procedures described. Each was grown overnight on agar plates and a heavy inoculum transferred to a sectored agar plate supplemented with IPTG to induce expression of the fusion protein. After three hours at 37 degrees the plate was photographed under UV light. |
PMC1560372_F3_7025.jpg | What is the principal component of this image? | Direct selection of Pc 23–231-GFP mutants with increased fluorescence. Fluorescence of the three prion mutants (17, 22 and 25) isolated by the procedures described. Each was grown overnight on agar plates and a heavy inoculum transferred to a sectored agar plate supplemented with IPTG to induce expression of the fusion protein. After three hours at 37 degrees the plate was photographed under UV light. |
PMC1560372_F3_7024.jpg | What object or scene is depicted here? | Direct selection of Pc 23–231-GFP mutants with increased fluorescence. Fluorescence of the three prion mutants (17, 22 and 25) isolated by the procedures described. Each was grown overnight on agar plates and a heavy inoculum transferred to a sectored agar plate supplemented with IPTG to induce expression of the fusion protein. After three hours at 37 degrees the plate was photographed under UV light. |
PMC1560393_F2_7029.jpg | What is being portrayed in this visual content? | Angiogenic response elicited by tumor masses growing in the cremaster muscle of athymic nude rats. The cremaster muscle of athymic male nude rats were inoculated with 5 × 104 human T24 bladder carcinoma cells. Ten days after tumor cell inoculation rats were sacrificed and mounted for photographic documentation. Concurrent with tumor growth we observed recruitment of new blood vessels that grew in a concentric pattern. Peri-tumoral edema characteristic of tumor growth can be observed. A. 1× magnification of the cremaster muscle bearing tumors on both sides of the principal artery, B. 2× magnification of left tumor, C. 2× magnification of the right tumor. |
PMC1560393_F2_7030.jpg | What is the central feature of this picture? | Angiogenic response elicited by tumor masses growing in the cremaster muscle of athymic nude rats. The cremaster muscle of athymic male nude rats were inoculated with 5 × 104 human T24 bladder carcinoma cells. Ten days after tumor cell inoculation rats were sacrificed and mounted for photographic documentation. Concurrent with tumor growth we observed recruitment of new blood vessels that grew in a concentric pattern. Peri-tumoral edema characteristic of tumor growth can be observed. A. 1× magnification of the cremaster muscle bearing tumors on both sides of the principal artery, B. 2× magnification of left tumor, C. 2× magnification of the right tumor. |
PMC1560393_F2_7028.jpg | What can you see in this picture? | Angiogenic response elicited by tumor masses growing in the cremaster muscle of athymic nude rats. The cremaster muscle of athymic male nude rats were inoculated with 5 × 104 human T24 bladder carcinoma cells. Ten days after tumor cell inoculation rats were sacrificed and mounted for photographic documentation. Concurrent with tumor growth we observed recruitment of new blood vessels that grew in a concentric pattern. Peri-tumoral edema characteristic of tumor growth can be observed. A. 1× magnification of the cremaster muscle bearing tumors on both sides of the principal artery, B. 2× magnification of left tumor, C. 2× magnification of the right tumor. |
PMC1560393_F3_7032.jpg | What is the main focus of this visual representation? | Intra-arterial adenoviral mediated transfection of tumors grown in the cremaster muscle of athymic nude rats. Tumors from two different animals are shown. The cremaster muscle of athymic male nude rats were inoculated with 5 × 104 cells of the human bladder carcinoma cell line T24. Ten days after tumor cell implantation, the cremaster muscle flap was intra-arterially infused with 1 × 109 pfus of a recombinant adenovirus encoding the green fluorescent protein gene (Ad5-CMV-GFP) and were left to incubate for 1 hour. Seventy two hours after viral infusion cremasters were set up for standard micro-photography and fluorescent confocal microscopy and photography as described in materials and methods. Texas red fluorescent micro beads were used to counter stain the muscle and tumor vasculature. Panel A: 2X Photographic image of a tumor using a standard stereoscopic microscope. Panel B Confocal fluorescent photography of the same tumor. Panel C: 2X Photographic image of a tumor using a standard stereoscopic microscope on a second animal. Panel D: Confocal fluorescent photography of the same tumor. Green fluorescent protein can be seen expressed throughout the tumor mass. A concentric neoangiogenic response can be seen as well. |
PMC1560393_F3_7033.jpg | What is being portrayed in this visual content? | Intra-arterial adenoviral mediated transfection of tumors grown in the cremaster muscle of athymic nude rats. Tumors from two different animals are shown. The cremaster muscle of athymic male nude rats were inoculated with 5 × 104 cells of the human bladder carcinoma cell line T24. Ten days after tumor cell implantation, the cremaster muscle flap was intra-arterially infused with 1 × 109 pfus of a recombinant adenovirus encoding the green fluorescent protein gene (Ad5-CMV-GFP) and were left to incubate for 1 hour. Seventy two hours after viral infusion cremasters were set up for standard micro-photography and fluorescent confocal microscopy and photography as described in materials and methods. Texas red fluorescent micro beads were used to counter stain the muscle and tumor vasculature. Panel A: 2X Photographic image of a tumor using a standard stereoscopic microscope. Panel B Confocal fluorescent photography of the same tumor. Panel C: 2X Photographic image of a tumor using a standard stereoscopic microscope on a second animal. Panel D: Confocal fluorescent photography of the same tumor. Green fluorescent protein can be seen expressed throughout the tumor mass. A concentric neoangiogenic response can be seen as well. |
PMC1560393_F3_7034.jpg | Can you identify the primary element in this image? | Intra-arterial adenoviral mediated transfection of tumors grown in the cremaster muscle of athymic nude rats. Tumors from two different animals are shown. The cremaster muscle of athymic male nude rats were inoculated with 5 × 104 cells of the human bladder carcinoma cell line T24. Ten days after tumor cell implantation, the cremaster muscle flap was intra-arterially infused with 1 × 109 pfus of a recombinant adenovirus encoding the green fluorescent protein gene (Ad5-CMV-GFP) and were left to incubate for 1 hour. Seventy two hours after viral infusion cremasters were set up for standard micro-photography and fluorescent confocal microscopy and photography as described in materials and methods. Texas red fluorescent micro beads were used to counter stain the muscle and tumor vasculature. Panel A: 2X Photographic image of a tumor using a standard stereoscopic microscope. Panel B Confocal fluorescent photography of the same tumor. Panel C: 2X Photographic image of a tumor using a standard stereoscopic microscope on a second animal. Panel D: Confocal fluorescent photography of the same tumor. Green fluorescent protein can be seen expressed throughout the tumor mass. A concentric neoangiogenic response can be seen as well. |
PMC1560393_F3_7031.jpg | What is the central feature of this picture? | Intra-arterial adenoviral mediated transfection of tumors grown in the cremaster muscle of athymic nude rats. Tumors from two different animals are shown. The cremaster muscle of athymic male nude rats were inoculated with 5 × 104 cells of the human bladder carcinoma cell line T24. Ten days after tumor cell implantation, the cremaster muscle flap was intra-arterially infused with 1 × 109 pfus of a recombinant adenovirus encoding the green fluorescent protein gene (Ad5-CMV-GFP) and were left to incubate for 1 hour. Seventy two hours after viral infusion cremasters were set up for standard micro-photography and fluorescent confocal microscopy and photography as described in materials and methods. Texas red fluorescent micro beads were used to counter stain the muscle and tumor vasculature. Panel A: 2X Photographic image of a tumor using a standard stereoscopic microscope. Panel B Confocal fluorescent photography of the same tumor. Panel C: 2X Photographic image of a tumor using a standard stereoscopic microscope on a second animal. Panel D: Confocal fluorescent photography of the same tumor. Green fluorescent protein can be seen expressed throughout the tumor mass. A concentric neoangiogenic response can be seen as well. |
PMC1562402_F3_7035.jpg | Describe the main subject of this image. | MRI composite Sagittal T1 weighted MRI image showing enlargement and hyperintensities involving the posterior elements of the cervical vertebrae. Sagittal T2 weighted MRI image showing a cervical cord contusion at C 4–5 level (Green arrow). |
PMC1562402_F4_7037.jpg | What is the principal component of this image? | CT scan bone windows showing diffuse thickening of the skull bones with widening of the diploic space. |
PMC1562402_F4_7039.jpg | Describe the main subject of this image. | CT scan bone windows showing diffuse thickening of the skull bones with widening of the diploic space. |
PMC1562402_F4_7038.jpg | What is the dominant medical problem in this image? | CT scan bone windows showing diffuse thickening of the skull bones with widening of the diploic space. |
PMC1562412_F1_7043.jpg | What stands out most in this visual? | a. Native ventilation MR image of one patient during expiration and inspiration. For precise measurement the region of interest would have to move during the respiratory cycle, we therefore include a schematic of our theoretical considerations. The four circles schematically represent four alveoli in a volume (voxel). During inspiration, tissue will be replaced by air causing a lower MR signal as shown on the right. In the same volume now only one of the "Alveoli" will give a signal. The ventilation can be derived from this signal change. b. Upper images: native (unregistered) MR ventilation images during expiration and inspiration. Measurements at the same location are almost impossible while the lung is moving as the same region of interest can not be exactly located. Note the different MR signal and the different size and shape of the lung. Lower images: Registered images. The registration process artificially changes the volume of the lung. An interpolation of the original image intensity values was used to compute the warped image when specific regions are expanded or contracted. The signal changes of the lung are then noted, the size and shape of the thorax stay the same. This way the signal change of each pixel can be measured and ventilation calculated. Note the different MR signal. In contrast to the upper images size and shape of the lung stay unchanged. |
PMC1562412_F1_7044.jpg | What object or scene is depicted here? | a. Native ventilation MR image of one patient during expiration and inspiration. For precise measurement the region of interest would have to move during the respiratory cycle, we therefore include a schematic of our theoretical considerations. The four circles schematically represent four alveoli in a volume (voxel). During inspiration, tissue will be replaced by air causing a lower MR signal as shown on the right. In the same volume now only one of the "Alveoli" will give a signal. The ventilation can be derived from this signal change. b. Upper images: native (unregistered) MR ventilation images during expiration and inspiration. Measurements at the same location are almost impossible while the lung is moving as the same region of interest can not be exactly located. Note the different MR signal and the different size and shape of the lung. Lower images: Registered images. The registration process artificially changes the volume of the lung. An interpolation of the original image intensity values was used to compute the warped image when specific regions are expanded or contracted. The signal changes of the lung are then noted, the size and shape of the thorax stay the same. This way the signal change of each pixel can be measured and ventilation calculated. Note the different MR signal. In contrast to the upper images size and shape of the lung stay unchanged. |
PMC1562412_F1_7045.jpg | What is being portrayed in this visual content? | a. Native ventilation MR image of one patient during expiration and inspiration. For precise measurement the region of interest would have to move during the respiratory cycle, we therefore include a schematic of our theoretical considerations. The four circles schematically represent four alveoli in a volume (voxel). During inspiration, tissue will be replaced by air causing a lower MR signal as shown on the right. In the same volume now only one of the "Alveoli" will give a signal. The ventilation can be derived from this signal change. b. Upper images: native (unregistered) MR ventilation images during expiration and inspiration. Measurements at the same location are almost impossible while the lung is moving as the same region of interest can not be exactly located. Note the different MR signal and the different size and shape of the lung. Lower images: Registered images. The registration process artificially changes the volume of the lung. An interpolation of the original image intensity values was used to compute the warped image when specific regions are expanded or contracted. The signal changes of the lung are then noted, the size and shape of the thorax stay the same. This way the signal change of each pixel can be measured and ventilation calculated. Note the different MR signal. In contrast to the upper images size and shape of the lung stay unchanged. |
PMC1562412_F1_7048.jpg | What can you see in this picture? | a. Native ventilation MR image of one patient during expiration and inspiration. For precise measurement the region of interest would have to move during the respiratory cycle, we therefore include a schematic of our theoretical considerations. The four circles schematically represent four alveoli in a volume (voxel). During inspiration, tissue will be replaced by air causing a lower MR signal as shown on the right. In the same volume now only one of the "Alveoli" will give a signal. The ventilation can be derived from this signal change. b. Upper images: native (unregistered) MR ventilation images during expiration and inspiration. Measurements at the same location are almost impossible while the lung is moving as the same region of interest can not be exactly located. Note the different MR signal and the different size and shape of the lung. Lower images: Registered images. The registration process artificially changes the volume of the lung. An interpolation of the original image intensity values was used to compute the warped image when specific regions are expanded or contracted. The signal changes of the lung are then noted, the size and shape of the thorax stay the same. This way the signal change of each pixel can be measured and ventilation calculated. Note the different MR signal. In contrast to the upper images size and shape of the lung stay unchanged. |
PMC1562412_F1_7041.jpg | What is the main focus of this visual representation? | a. Native ventilation MR image of one patient during expiration and inspiration. For precise measurement the region of interest would have to move during the respiratory cycle, we therefore include a schematic of our theoretical considerations. The four circles schematically represent four alveoli in a volume (voxel). During inspiration, tissue will be replaced by air causing a lower MR signal as shown on the right. In the same volume now only one of the "Alveoli" will give a signal. The ventilation can be derived from this signal change. b. Upper images: native (unregistered) MR ventilation images during expiration and inspiration. Measurements at the same location are almost impossible while the lung is moving as the same region of interest can not be exactly located. Note the different MR signal and the different size and shape of the lung. Lower images: Registered images. The registration process artificially changes the volume of the lung. An interpolation of the original image intensity values was used to compute the warped image when specific regions are expanded or contracted. The signal changes of the lung are then noted, the size and shape of the thorax stay the same. This way the signal change of each pixel can be measured and ventilation calculated. Note the different MR signal. In contrast to the upper images size and shape of the lung stay unchanged. |
PMC1563447_F2_7054.jpg | What does this image primarily show? | A) Head MRI (left panels) demonstrates cortical atrophy in frontal and temporal lobes. Positron emission tomography (PET) with 2-deoxy-2-fluoro- [18F]-D-glucose (FDG) PET (right panels) demonstrates hypometabolism in the same cortical regions. Middle panels show co-registration of MRI and FDG PET studies. B) Thermoregulatory sweating tests in the same patient with PPND. Shaded areas represent sweating over the anterior body surface. Distal anhidrosis is seen. |
PMC1563447_F2_7053.jpg | What is the core subject represented in this visual? | A) Head MRI (left panels) demonstrates cortical atrophy in frontal and temporal lobes. Positron emission tomography (PET) with 2-deoxy-2-fluoro- [18F]-D-glucose (FDG) PET (right panels) demonstrates hypometabolism in the same cortical regions. Middle panels show co-registration of MRI and FDG PET studies. B) Thermoregulatory sweating tests in the same patient with PPND. Shaded areas represent sweating over the anterior body surface. Distal anhidrosis is seen. |
PMC1563456_F6_7055.jpg | Can you identify the primary element in this image? | Our procedure allows automated production of a map that identifies locations of interest in an electron micrograph, illustrated here for the C test function. Instead of simply counting and comparing structures in an unprocessed image, the virologist is aided considerably in this task by the availability of such a map. The various structures are sorted left to right in order of descending matching values beginning at the left side of the top row. |
PMC1563456_F7_7060.jpg | What key item or scene is captured in this photo? | Use of an ellipse to detect linear deformations of virus particles in electron micrographs. Image A has an elliptical shape, whereas image B has been deformed as described to make it circular. |
PMC1563456_F8_7059.jpg | What can you see in this picture? | Test functions for viral capsid structures (A, B and C) in electron micrographs employing no coefficient reduction (None) or 80% of the coefficients exhibiting least variation (VAR). |
PMC1563456_F8_7057.jpg | What stands out most in this visual? | Test functions for viral capsid structures (A, B and C) in electron micrographs employing no coefficient reduction (None) or 80% of the coefficients exhibiting least variation (VAR). |
PMC1563456_F10_7062.jpg | What key item or scene is captured in this photo? | Matching with the test function A inside of a vesicle. The structure marked with a blue cross fulfills matching criteria (i) and (ii) whereas those marked with a red circle only fulfill criterion (i). |
PMC1563459_F4_7066.jpg | What's the most prominent thing you notice in this picture? | CLSM images of perfused and rotated specimen. Laser scanning micrographs showing the three-dimensional aspect of the capillary-like network in the luminal region of the vessel wall. In perfused specimens, the capillary-like network has a physiological, interconnected appearance (A), whereas in the rotated specimen from the same experiment (B) capillary-like structures are short and interrupted. Note the concentric organisation of capillary-like structures around the vessel lumen under pulsatile perfusion. In both cases, micrographs show the inner luminal portion. lu = central lumen of the vessel equivalent. Length of the pictures = 800 μm, maximum projection of a 60 μm deep scan, UEA-I-TRITC labelling, green excitation. |
PMC1563459_F4_7065.jpg | What is the main focus of this visual representation? | CLSM images of perfused and rotated specimen. Laser scanning micrographs showing the three-dimensional aspect of the capillary-like network in the luminal region of the vessel wall. In perfused specimens, the capillary-like network has a physiological, interconnected appearance (A), whereas in the rotated specimen from the same experiment (B) capillary-like structures are short and interrupted. Note the concentric organisation of capillary-like structures around the vessel lumen under pulsatile perfusion. In both cases, micrographs show the inner luminal portion. lu = central lumen of the vessel equivalent. Length of the pictures = 800 μm, maximum projection of a 60 μm deep scan, UEA-I-TRITC labelling, green excitation. |
PMC1563461_F1_7064.jpg | What is being portrayed in this visual content? | Magnetic Resonance Image of a HMGA2 transgenic mouse showing a pituitary adenoma (indicated in circle). |
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