sot_question stringlengths 42 9.8k | ds_name stringclasses 8
values | pred_label int64 0 2 | logits listlengths 3 3 |
|---|---|---|---|
['Human adipose stem cells (hASCs) can promote angiogenesis through secretion of proangiogenic factors such as vascular endothelial growth factor (VEGF). In other cell types, it has been shown that induction of VEGF is mediated by both protease activated receptor 2 (PAR2) and hypoxia inducible factor 1(HIF-1). The pres... | qiaojin/PubMedQA | 2 | [
-2.3582041263580322,
-1.2806649208068848,
2.6527976989746094
] |
['Typhoidal and non-typhoidal infection by Salmonella is a serious threat to human health. Ciprofloxacin is the last drug of choice to clear the infection. Ciprofloxacin, a gyrase inhibitor, kills bacteria by inducing chromosome fragmentation, SOS response and reactive oxygen species (ROS) in the bacterial cell. Curcum... | qiaojin/PubMedQA | 2 | [
-2.518505811691284,
-1.2495864629745483,
2.800477981567383
] |
['Although endoscopic submucosal dissection (ESD)-induced ulcers heal faster and recur less often than non-iatrogenic gastric ulcers, the optimal dosage and duration of proton pump inhibitor treatment for ESD-induced ulcers remain unclear.', 'To evaluate the efficacy of half-dose rabeprazole on endoscopic submucosal di... | qiaojin/PubMedQA | 2 | [
-1.843217134475708,
-1.4833394289016724,
2.3746914863586426
] |
['Arginine (Arg) is deficient in the serum of the preterm neonate and is lower in those developing intestinal ischemia. We investigated whether Arg or its precursor, citrulline (Cit), protects intestinal tight junctions (TJs) from hypoxia (HX) and determined whether inducible nitric oxide (NO) plays a role.', 'Neonatal... | qiaojin/PubMedQA | 2 | [
-2.404353380203247,
-1.3903634548187256,
2.8131446838378906
] |
['Enhancing collaboration has been highlighted as a marker for future success in maternity care, although this suggestion comes with little methodological guidance. This study assessed the efficacy of a collaborative partnership between obstetric doctors and midwives providing Midwifery Group Practice (MGP) care.', 'A ... | qiaojin/PubMedQA | 2 | [
-1.9325023889541626,
0.3133733868598938,
0.7203880548477173
] |
['Arbuscular mycorrhizas (AM) are widespread symbioses that provide great advantages to the plant, improving its nutritional status and allowing the fungus to complete its life cycle. Nevertheless, molecular mechanisms that lead to the development of AM symbiosis are not yet fully deciphered. Here, we have focused on t... | qiaojin/PubMedQA | 2 | [
-2.517183303833008,
-0.9269813895225525,
2.517821788787842
] |
['Survival benefits of mild hypothermia in animals suffering from uncontrolled hemorrhagic shock (HS) may be influenced by trauma severity. We hypothesized that mild hypothermia would improve early outcomes based on our rabbit model of severe traumatic HS.', 'Fifty male New Zealand rabbits weighing between 1.6 and 2.2 ... | qiaojin/PubMedQA | 2 | [
-1.7247599363327026,
-1.4207971096038818,
2.1035590171813965
] |
['Blood omega-3 and omega-6 fatty acid levels have been associated with reduced risk for total mortality in patients with stable coronary heart disease (CHD), but their relationships with mortality in the setting of myocardial infarction (MI) are unknown.', 'To determine the association between red blood cell (RBC) fat... | qiaojin/PubMedQA | 2 | [
-1.6002343893051147,
-1.5477962493896484,
2.1384634971618652
] |
['Phosphatidate phosphatase (PAP) plays diverse roles in lipid metabolism and cell signaling.', 'A novel yeast PAP is identified as the actin patch protein encoded by APP1.'] Is the Saccharomyces cerevisiae actin patch protein App1p a phosphatidate phosphatase enzyme? | qiaojin/PubMedQA | 2 | [
-2.5029304027557373,
-0.8101771473884583,
2.3747711181640625
] |
['To investigate whether diabetes mellitus (DM) was associated with postoperative outcomes, including prostate-specific antigen doubling time, among men who underwent radical prostatectomy (RP) for clinically localized prostate cancer (PCa).', 'Data of 661 patients who underwent radical prostatectomy for node-negative ... | qiaojin/PubMedQA | 2 | [
-2.081325054168701,
-1.310823678970337,
2.456345796585083
] |
['To examine the relationship between hematologic parameters at birth and prenatal progression of Doppler abnormalities in fetal growth restriction (FGR).', 'The study was a secondary analysis of FGR patients (abdominal circumference < 5th percentile and umbilical artery pulsatility index (UA-PI) elevation) with at lea... | qiaojin/PubMedQA | 2 | [
-1.8129514455795288,
-1.5996348857879639,
2.4545252323150635
] |
["The clinical uses of 2-chloro-2'-deoxyadenosine (2-CDA) or cladribine which was initially prescribed to patients with hematological and lymphoid cancers is now extended to treat patients with multiple sclerosis (MS). Previous data has shown that 2-CDA has high affinity to the brain and readily passes through the bloo... | qiaojin/PubMedQA | 2 | [
-2.45487904548645,
-1.210914134979248,
2.754037380218506
] |
['Effect modification by obesity or obesity-related phenotypes (e.g. physical activity and diet) was observed in some candidate gene studies on lipids. We aimed to evaluate gene-obesity interaction effects on HDL (HDL-C), LDL (LDL-C) and total cholesterol (TC) levels using genetic predisposition scores.', 'We derived i... | qiaojin/PubMedQA | 2 | [
-1.252663254737854,
-1.455620288848877,
1.7182433605194092
] |
['Psoriasis has been associated with cardiovascular diseases, but its relationship to markers of subclinical atherosclerosis has not been fully elucidated. The aim of the study is to analyze the association of psoriasis with common carotid artery intima-media thickness (CCA-IMT) and plaque prevalence of the carotid art... | qiaojin/PubMedQA | 2 | [
-2.325792074203491,
-1.0366495847702026,
2.471219062805176
] |
['Intranasal corticosteroids are effective in controlling allergic rhinitis (AR) symptoms; however, chronic administration of corticosteroids may suppress hypothalamic-pituitary-adrenal (HPA)-axis function.', 'To evaluate the effects of 6 weeks of treatment with beclomethasone dipropionate (BDP) hydrofluoroalkane nasal... | qiaojin/PubMedQA | 2 | [
-1.4527990818023682,
-1.6959822177886963,
2.1081032752990723
] |
['Acoustically evoked neural and hair cell potentials can be measured from the round window (RW) intraoperatively in the general population of cochlear implant recipients.', 'Cochlear implant performance varies greatly among patients. Improved methods to assess and monitor functional hair cell and neural substrate befo... | qiaojin/PubMedQA | 2 | [
-2.3227121829986572,
-1.104766607284546,
2.4904353618621826
] |
['To investigate the clinical significance of micro-ribonucleic acid-155 in clear cell renal cell carcinoma, in particular focusing on the association of expression levels of micro-ribonucleic acid-155 with clinicopathological factors, cancer-specific survival and therapeutic outcomes in clear cell renal cell carcinoma... | qiaojin/PubMedQA | 2 | [
-2.4324114322662354,
-1.2892327308654785,
2.7651290893554688
] |
['To develop and evaluate survey questions that assess processes of care relevant to Patient-Centered Medical Homes (PCMHs).', 'We convened expert panels, reviewed evidence on effective care practices and existing surveys, elicited broad public input, and conducted cognitive interviews and a field test to develop items... | qiaojin/PubMedQA | 2 | [
-1.6420949697494507,
-0.37533149123191833,
1.1251485347747803
] |
['Left atrial (LA) strain as a marker for discrimination of risk for stroke and transient ischemic attack (TIA) in patients with atrial fibrillation and low-risk CHADS(2) scores (≤1) has yet to be examined.', 'Patients with atrial fibrillation, stroke or TIA, and CHADS(2) scores ≤ 1 before their events were identified ... | qiaojin/PubMedQA | 2 | [
-1.489558458328247,
-1.5032292604446411,
2.041698694229126
] |
['Because of the infrequence of salivary gland tumours and their complex histopathological diagnosis it is still difficult to exactly predict their clinical course by means of recurrence, malignant progression and metastasis. In order to define new proliferation associated genes, purpose of this study was to investigat... | qiaojin/PubMedQA | 2 | [
-2.219785690307617,
-1.3561805486679077,
2.676372528076172
] |
['In Xenopus early embryogenesis, various genes are involved with mesoderm formation. In particular, dorsal mesoderm contains the organizer region and induces neural tissues through the inhibition of bone morphogenetic protein (BMP) signaling. In our initial study to identify novel genes necessary for maintaining the u... | qiaojin/PubMedQA | 2 | [
-2.5519490242004395,
-0.9947500228881836,
2.622410297393799
] |
['Peripheral vascular disease in pre-diabetes may involve altered sympathetically-mediated vascular control. Thus, we investigated if pre-diabetes modifies baseline sympathetic Y(1)-receptor (Y(1)R) and α(1)-receptor (α(1)R) control of hindlimb blood flow (Q(fem)) and vascular conductance (VC).', 'Q(fem) and VC were me... | qiaojin/PubMedQA | 2 | [
-2.0071847438812256,
-1.5124534368515015,
2.4908268451690674
] |
['The genetic predisposition to obesity may have contributed to the obesity epidemic through assortative mating. We investigated whether spouses were positively assorted by body mass index (BMI; = kg/m(2)) in late childhood, and whether changes in assorted marriage by upper BMI-percentiles occurred during the obesity e... | qiaojin/PubMedQA | 0 | [
0.5872684717178345,
-0.18710926175117493,
-1.205683946609497
] |
['The modification of radiation-induced lung injuries by melatonin was studied by measuring changes in oxidative stress, cytokine expression and histopathology in the lung tissue of mice following irradiation.', 'The thoraces of C57BL/6 mice were exposed to a single X-ray radiation dose of 12 Gy with or without 200 mg/... | qiaojin/PubMedQA | 2 | [
-2.4167168140411377,
-1.360595703125,
2.8341188430786133
] |
['Vitronectin is involved in the whole process of atherosclerosis. Our aim is to determine the association of VTN functional promoter variants with different types of vascular disease, and conclude the roles of vitronectin involved in vascular disease.', 'Gel shift assays and luciferase reporter assays were used to det... | qiaojin/PubMedQA | 2 | [
-1.5205267667770386,
-1.6052851676940918,
2.0812668800354004
] |
['Total isovolumic time (t-IVT) reflects left ventricular (LV) asynchrony (when the ventricle is neither ejecting nor filling). It is prolonged in left bundle branch block (LBBB). Cardiac resynchronisation therapy (CRT) is a treatment for patients with heart failure, reduced LV ejection fraction and LBBB. CRT shortens ... | qiaojin/PubMedQA | 2 | [
-0.36661598086357117,
-1.9191374778747559,
1.2848888635635376
] |
['Retrospective review.', 'To determine the incremental cost-effectiveness of cell saver for single-level posterior lumbar decompression and fusion (PLDF).', 'Intraoperative cell salvage is used during surgery to reduce the need for perioperative allogeneic blood transfusion. Although the use of cell saver may be benef... | qiaojin/PubMedQA | 2 | [
-1.2219113111495972,
-1.6336647272109985,
1.7602589130401611
] |
['Prolyl hydroxylase (PHD) inhibitors can induce a proangiogenic response that stimulates regeneration in soft and hard tissues. However, the effect of PHD inhibitors on the dental pulp is unclear. The purpose of this study was to evaluate the effects of PHD inhibitors on the proangiogenic capacity of human dental pulp... | qiaojin/PubMedQA | 2 | [
-2.5478732585906982,
-1.1776480674743652,
2.768253803253174
] |
['A diabody is a bispecific antibody that is capable of recruiting a polyclonal T cell to antibody target-expressing tumor cells. However, the two chains of diabodies tend to dissociate because they are integrated non-covalently. Therefore, it is necessary to remodel the diabody to increase its stability in order to en... | qiaojin/PubMedQA | 2 | [
-2.386063814163208,
-1.2805789709091187,
2.753836154937744
] |
['What are the aneuploidy rates and incidence of mosaicism in good-quality human preimplantation embryos.'] Does microarray analysis reveal abnormal chromosomal complements in over 70 % of 14 normally developing human embryos? | qiaojin/PubMedQA | 2 | [
-2.244582414627075,
-0.7149434685707092,
2.097775936126709
] |
['Current pharmacotherapy is highly effective in the clinical management of the majority of patients with stable asthma, however severe asthma remains inadequately treated. Prevention of airway remodelling is a major unmet clinical need in the management of patients with chronic severe asthma and other inflammatory lun... | qiaojin/PubMedQA | 2 | [
-2.499565839767456,
-1.2798980474472046,
2.8466150760650635
] |
['Lower ambulatory performance with aging may be related to a reduced oxidative capacity within skeletal muscle. This study examined the associations between skeletal muscle mitochondrial capacity and efficiency with walking performance in a group of older adults.', 'Thirty-seven older adults (mean age 78 years; 21 men... | qiaojin/PubMedQA | 2 | [
-1.4419434070587158,
-1.5385065078735352,
1.9601759910583496
] |
['Successful outcomes following high tibial osteotomy (HTO) require precise realignment of the mechanical axis of the lower extremity. The present study investigated whether the weight-bearing limb scanogram (WBS) technique provided a more accurate mechanical axis realignment than the navigation technique in open high ... | qiaojin/PubMedQA | 2 | [
-1.0987505912780762,
-1.5719389915466309,
1.7238810062408447
] |
['The aim of our study was to estimate the expressions of both B7-H1 and B7-H4 as well as CD200 and CD200R co-stimulatory molecules on immature myeloid and lymphoid dendritic cells, B CD19(+) lymphocytes and monocytes in umbilical cord blood of healthy neonates and in peripheral blood of healthy adults.', "Thirty-nine... | qiaojin/PubMedQA | 2 | [
-1.9299192428588867,
-1.413392186164856,
2.419833183288574
] |
['Renin-angiotensin-aldosterone system blockade with a mineralocorticoid-receptor antagonist has not yet been studied in exposure to tobacco smoke (TS) models. Thus, this study investigated the role of spironolactone on cardiac remodeling induced by exposure to tobacco smoke.', 'Male Wistar rats were divided into 4 gro... | qiaojin/PubMedQA | 2 | [
-2.2258737087249756,
-1.4573992490768433,
2.6684794425964355
] |
['The chemokine, Ccl2, and the fractalkine receptor, Cx3cr1, have both been implicated in the pathogenesis of age related macular degeneration (AMD), with mice lacking both genes exhibiting features of AMD by 3 months of age. However, recent reports indicate that this ascribed phenotype is due to the presence of a reti... | qiaojin/PubMedQA | 2 | [
-2.292249917984009,
-1.419039011001587,
2.7195732593536377
] |
['Glutamate homeostasis plays a critical role in mediating the addiction-related behaviors. Therefore, preventing the disruption or reestablishing of it is a novel strategy for the treatment of addiction. Glutamate transporters are responsible for clearing extracellular glutamate and maintaining glutamate homeostasis. ... | qiaojin/PubMedQA | 2 | [
-2.4163260459899902,
-1.0434246063232422,
2.4543776512145996
] |
['This pilot trial was designed to determine if an optimal dose of Technosphere(®) insulin (TI) inhalation powder (MannKind Corp., Valencia, CA) could be used regardless of variation in meal carbohydrate (CHO) content.', 'In total, eight subjects (seven men, one woman) with type 2 diabetes were enrolled. Subjects under... | qiaojin/PubMedQA | 2 | [
0.20473569631576538,
-1.8963172435760498,
0.7496142387390137
] |
['Diabetes mellitus (DM) is identified as a negative prognostic indicator in hepatocellular carcinoma (HCC).', 'A retrospective review of HCC patients was conducted to assess the effect of DM on clinical variables.', 'Ninety-seven of 265 (34%) patients had DM at the time of diagnosis. Distant metastasis was found in 33... | qiaojin/PubMedQA | 2 | [
-1.528748631477356,
-1.4057459831237793,
1.947298526763916
] |
['To delineate a novel autosomal recessive multiple congenital anomaly-mental retardation (MCA-MR) syndrome in 2 female siblings of a consanguineous pedigree and to identify the disease-causing mutation.', 'Both siblings were clinically characterized and homozygosity mapping and sequencing of\xa0candidate genes were ap... | qiaojin/PubMedQA | 2 | [
-2.2586846351623535,
-1.1016696691513062,
2.4075686931610107
] |
['Liver ischemia-reperfusion injury (IRI) is a known risk factor for the postoperative outcome of patients undergoing liver surgery/transplantation. Attempts to protect from organ damage require multidisciplinary strategies and are of emerging interest in view of patients with higher age and American Society of Anesthe... | qiaojin/PubMedQA | 2 | [
-2.476491689682007,
-1.3319929838180542,
2.8583366870880127
] |
['Though highly prevalent, the pathophysiology of orthostatic hypotension (OH), postprandial hypotension (PPH), and carotid sinus hypersensitivity (CSH) are rarely studied together. Therefore, we conducted such a comprehensive study focusing on the common role of the cardiovascular autonomic system. We hypothesized tha... | qiaojin/PubMedQA | 2 | [
-2.47314715385437,
-0.9054160118103027,
2.425114631652832
] |
['Hepatic non-parenchymal cells are well known to be capable of providing an important microenvironment and growth factors for hepatic regeneration, but their capacity for directing embryonic stem cells (ESC) toward hepatocytes remains to be assessed. Thus, this study aims to investigate the role of hepatic stellate ce... | qiaojin/PubMedQA | 2 | [
-2.3404486179351807,
-1.32102632522583,
2.7353529930114746
] |
['We investigated the possible involvement of H2S in nitric oxide independent inhibitory neurotransmission to the pig bladder neck.', 'We used immunohistochemistry to determine the expression of the H2S synthesis enzymes cystathionine γ-lyase and cystathionine β-synthase. We also used electrical field stimulation and m... | qiaojin/PubMedQA | 2 | [
-2.478402853012085,
-1.3272360563278198,
2.8414273262023926
] |
['Qualitative methods were used to better understand how to obtain interviewer-administered recalls of physical activity from children.', "Subjects were 24 third- and fifth-grade children from 1 school in Columbia, South Carolina. Cognitive interviews targeted different retention intervals (about the same or previous s... | qiaojin/PubMedQA | 2 | [
-1.059395432472229,
-0.3721315562725067,
0.6148017048835754
] |
['Although total abdominal colectomy has long been considered definitive treatment for fulminant ulcerative colitis refractory to medical management, the optimal timing of surgery remains controversial. Early surgical intervention may be beneficial to patients with acute ulcerative colitis. Our goal was to compare outc... | qiaojin/PubMedQA | 2 | [
-1.8656433820724487,
-1.406677484512329,
2.2722907066345215
] |
['To examine associations between quantitatively measured retinal vessel caliber and the 10-year incidence of primary open-angle glaucoma (OAG).', 'Population-based cohort study.', 'The Blue Mountains Eye Study examined 3654 persons at baseline and 2461 persons at either 5 years, 10 years, or both times. After excludin... | qiaojin/PubMedQA | 2 | [
-1.788488745689392,
-1.4902113676071167,
2.304957389831543
] |
['Isoflurane has been demonstrated to produce late preconditioning against myocardial stunning. We tested the hypothesis that this effect is dependent upon an increased production of nitric oxide.', 'Studies were performed in 18 conscious dogs, chronically instrumented to measure coronary blood flow and myocardial wall... | qiaojin/PubMedQA | 2 | [
-2.0551624298095703,
-1.5244967937469482,
2.573793649673462
] |
['Survival and progression of mature B-cell malignancies depend on signals from the B-cell antigen receptor, and Bruton tyrosine kinase (BTK) is a critical signaling kinase in this pathway. We evaluated ibrutinib (PCI-32765), a small-molecule irreversible inhibitor of BTK, in patients with B-cell malignancies.', 'Patie... | qiaojin/PubMedQA | 2 | [
-2.0234296321868896,
-1.5237890481948853,
2.5387134552001953
] |
['Adiponectin is a key molecule involved in metabolic syndrome. Single nucleotide polymorphisms (SNPs) in the ADIPOQ gene encoding adiponectin correlate with various diseases, such as diabetes mellitus; however, there is insufficient information about ADIPOQ SNPs and the onset of cardiovascular events.', 'This hospital... | qiaojin/PubMedQA | 2 | [
-1.9939595460891724,
-1.5022130012512207,
2.4541120529174805
] |
['Postsurgical thyrotropin (TSH)-stimulated serum thyroglobulin (Tg) level can be used to predict the likelihood of finding radioactive iodine (RAI) avid metastatic foci on postablation scanning. However, there is little data regarding the predictive value of a nonstimulated postoperative Tg obtained on levothyroxine t... | qiaojin/PubMedQA | 2 | [
-1.7609543800354004,
-1.6449946165084839,
2.4028468132019043
] |
['To determine if melanoma cells secrete chemotactic factors that result in the migration of multipotent stem cells.', 'In vitro cell culture.', 'Chemotaxis and invasion of human mesenchymal stem cells (hMSCs) was determined using the modified Boyden chamber assay. Quantification of growth factors secreted by melanoma ... | qiaojin/PubMedQA | 2 | [
-2.5552821159362793,
-1.0709917545318604,
2.721205234527588
] |
['The aim of this study was to evaluate cardiovascular autonomic function in a rodent obesity model induced by monosodium glutamate injections during the first seven days of life.', 'The animals were assigned to control (control, n = 10) and monosodium glutamate (monosodium glutamate, n = 13) groups. Thirty-three weeks... | qiaojin/PubMedQA | 2 | [
-2.2031445503234863,
-1.3277379274368286,
2.5526115894317627
] |
['Although PAK1 regulates cytoskeleton and microtubule dynamics, its role in controlling the functions of MCAK remains unknown.', 'PAK1 phosphorylates MCAK and thereby regulates both its localization and function.'] Does signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulate microtubule d... | qiaojin/PubMedQA | 2 | [
-2.3621675968170166,
-0.6711227297782898,
2.149153232574463
] |
['Postoperative adhesion formation after endoscopic sinus surgery (ESS) remains a complication associated with high revision rates. This study determines the efficacy of a sprayable chitosan/starch-based sealant for reducing adhesions in an ESS sheep model for chronic sinusitis.', 'Prospective, blinded, randomized cont... | qiaojin/PubMedQA | 2 | [
-2.005458116531372,
-1.4947373867034912,
2.495173215866089
] |
['Glucose and fatty acids comprise the primary substrates for myocardial energy metabolism. The normal myocardium switches toward glucose metabolism in the setting of stress; the inability to affect such a switch is a fundamental mechanism behind "diabetic" or "insulin-resistant" cardiomyopathy. The purpose of this mec... | qiaojin/PubMedQA | 2 | [
-2.3158228397369385,
-1.40558660030365,
2.7106690406799316
] |
['Exposing the brain to a sub-damaging stimulus can protect against a subsequent lethal insult, a phenomenon termed preconditioning. The aim of this study was to investigate the neuroprotective effect of low dose LPS (lipopolysaccharide) pretreatment in endotoxin induced periventricular leukomalacia (PVL) in a rat mode... | qiaojin/PubMedQA | 2 | [
-2.189805269241333,
-1.464813232421875,
2.6834607124328613
] |
['The immune system has been shown to play an important role in gastrointestinal stromal tumor (GIST). The neutrophil-to-lymphocyte ratio (NLR) in blood is an easily assessable parameter of systemic inflammatory response. The aim of this study was to determine whether the NLR is prognostic in GIST.', 'A total of 339 pr... | qiaojin/PubMedQA | 2 | [
-1.692535400390625,
-1.6608831882476807,
2.326779365539551
] |
['The impact of home monitoring system in the early detection of ventricular arrhythmia and inappropriate shock in daily work is not clear. The aim of this study was to investigate the impact of home monitoring system on the early detection of ventricular arrhythmia and inappropriate shock in daily clinical practice.',... | qiaojin/PubMedQA | 2 | [
-1.3697338104248047,
-1.4109134674072266,
1.8037915229797363
] |
['Men have a higher stroke incidence compared to women until advanced age. The contribution of hormones to these sex differences has been extensively debated. In experimental stroke, estradiol is neuroprotective, whereas androgens are detrimental. However, prior studies have only examined the effects of acute treatment... | qiaojin/PubMedQA | 2 | [
-2.4024460315704346,
-1.1367475986480713,
2.4753150939941406
] |
['Parthenogenetic embryonic stem cells (pESCs) derived from artificially activated oocytes without fertilization presumably raise minimal ethical concerns and may serve as attractive candidates for regenerative medicine. Here we investigated whether pESCs could repair myocardial infarction (MI), in comparison to embryo... | qiaojin/PubMedQA | 2 | [
-2.3354671001434326,
-1.2281506061553955,
2.6303939819335938
] |
['It has been speculated that the amount of leucine in a meal largely determines the post-prandial muscle protein synthetic response to food intake. The present study investigates the impact of leucine co-ingestion on subsequent post-prandial muscle protein accretion following the ingestion of a single bolus of dietary... | qiaojin/PubMedQA | 2 | [
-1.1444698572158813,
-1.62601637840271,
1.7156522274017334
] |
['While the death rate from acute coronary syndromes (ACS) has been in decline for more than 50 years, out-of-hospital mortality remains high despite improvements in care.', 'To evaluate the importance of out-of-hospital mortality and identify the main predictors of in-hospital and 1-year mortality in France.', 'Analys... | qiaojin/PubMedQA | 2 | [
-1.8649228811264038,
-0.5685699582099915,
1.5099124908447266
] |
['Epithelial sodium channel (ENaC) hyperactivity has been implicated in the pathogenesis of cystic fibrosis (CF) by dysregulation of fluid and electrolytes in the airways. In the present study, we show proof-of-principle for ENaC inhibition by lentiviral-mediated RNA interference.', 'Immortalized normal (H441) and CF m... | qiaojin/PubMedQA | 2 | [
-2.423853635787964,
-1.3902510404586792,
2.87722110748291
] |
['The objective of this study is to determine the utility of simple asthma control questionnaires in assessing the asthma control in our practice setting.', 'The Asthma Control Test (ACT), Asthma Therapy Assessment Questionnaire (ATAQ), and mini Asthma Quality of Life Questionnaire (mini AQLQ) were administered to prev... | qiaojin/PubMedQA | 2 | [
-0.9063975214958191,
-1.3048536777496338,
1.2774055004119873
] |
['Recurrent hypoglycaemia leads to an attenuation of hypoglycaemic symptoms and hormonal counterregulatory responses. This phenomenon poses a severe problem in the treatment of patients with diabetes mellitus, but the underlying neuroendocrine mechanisms are unclear. On the basis of animal experimental findings, we hyp... | qiaojin/PubMedQA | 2 | [
-2.324469804763794,
-1.357542634010315,
2.67594313621521
] |
['Adults with cochlear implants (CIs) are usually implanted unilaterally. To preserve binaural advantages, a noninvasive method involves maintaining the hearing aid (HA) on the contralateral ear; the choice of HA for this purpose is therefore crucial. In recent years, the use of frequency transposition has gained a ren... | qiaojin/PubMedQA | 2 | [
-2.265103578567505,
-1.2598683834075928,
2.5539979934692383
] |
['[corrected] After autologous stem cell transplantation (ASCT) the immunological B cell compartment recovers slowly. Delays on the recovery of B cell function after autologous stem cell transplantation are due to the low lymphocytes count and to their intrinsic dysfunction.', 'We studied the in vivo B cell reconstitut... | qiaojin/PubMedQA | 2 | [
-2.3821775913238525,
-1.3657104969024658,
2.804492712020874
] |
['For 2000 years, traditional Chinese medicine has been used as a remedy for general health improvement, including the fight against aging. Pearl powder has recently been used as a health food that has antioxidant, antiaging, antiradioactive, and tonic activities for cells; it is also applied to cure aphthous ulcer, ga... | qiaojin/PubMedQA | 2 | [
-2.2817986011505127,
-0.7674204707145691,
2.1520838737487793
] |
['Whether the expression of Golgi phosphoprotein 3 (GOLPH3) correlates with esophageal cancer tumorigenesis is currently unclear. The aim of this study was to examine GOLPH3 expression in patients with esophageal squamous cell cancer (ESCC) and explore its clinical significance.', 'Differences in the expression of GOLP... | qiaojin/PubMedQA | 2 | [
-2.3180088996887207,
-1.2246938943862915,
2.581784725189209
] |
['Mild hypoglycemia is associated with increased mortality in critically ill patients. However, data regarding the association between mild hypoglycemia and patient outcomes among patients with sepsis are limited.', 'Patients admitted to a medical ICU for sepsis, as defined by the Surviving Sepsis Campaign guidelines, ... | qiaojin/PubMedQA | 2 | [
-1.2784875631332397,
-1.5836989879608154,
1.7783665657043457
] |
['Existential/spiritual needs of advanced cancer patients are not always met in healthcare. Potential barriers for health professionals exploring existential concerns include lack of time, training, tools, and confidence. Yet patients with life-threatening illnesses require holistic care, and interest in their existent... | qiaojin/PubMedQA | 2 | [
-2.6501972675323486,
0.4889616370201111,
1.3494162559509277
] |
['We examined depressive symptoms, C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels during early to-midgestation.', 'We measured depressive symptoms on the Patient Health Questionnaire-9 (PHQ-9), and serum CRP, IL-6, and TNF-α levels twice in 27 pregnant women.', 'After adjustme... | qiaojin/PubMedQA | 2 | [
-1.9244574308395386,
-1.4562616348266602,
2.4335861206054688
] |
['Aberrant expression of interleukin-6 (IL-6) may play an important role in lung carcinogenesis. Whether IL-6 promoter haplotypes are associated with lung cancer risk and their functions have not yet been studied. We tested the hypothesis that single-nucleotide polymorphism (SNP) and/or haplotypes of IL-6 promoter are ... | qiaojin/PubMedQA | 2 | [
-1.3860710859298706,
-1.526498556137085,
1.8512526750564575
] |
['Hypoxia has been found to play an important role in regulating the biological characteristics of cancer stem cells (cCSCs). In this study, we tested whether a tumor hypoxic niche serves to the chemotherapeutic resistance of colon cCSCs.', 'Each of 23 fresh samples of human colon adenocarcinoma was transplanted into n... | qiaojin/PubMedQA | 2 | [
-1.9912065267562866,
-1.4894520044326782,
2.4670462608337402
] |
["Parkinson's disease is a debilitating neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons. We investigated the effects of treadmill exercise on dopaminergic neuronal loss and microglial activation using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/P)-induced Parkinson... | qiaojin/PubMedQA | 2 | [
-2.4998586177825928,
-1.2307473421096802,
2.7227835655212402
] |
['In asthma, reduced histone deacetylase activity and enhanced histone acetyltransferase activity in the lungs have been reported. However, the precise function of Sirtuin 1 (Sirt1), a class III histone deacetylase, and the effect of the Sirt1 activator SRT1720 on allergic inflammation have not been fully elucidated.',... | qiaojin/PubMedQA | 2 | [
-2.2372074127197266,
-1.401313304901123,
2.6240110397338867
] |
['Bovine leukemia virus (BLV) is worldwide distributed and highly endemic in Argentina. Among the strategies to prevent BLV dissemination, a control plan based on the selective segregation of animals according to their proviral load (PVL) is promising for our dairy productive system. The objective of this work was to s... | qiaojin/PubMedQA | 2 | [
0.0469055138528347,
-1.6334326267242432,
0.7030496001243591
] |
['Recently, lymphoblastoid cell lines (LCLs) have emerged as an innovative model system for mapping gene variants that predict the dose response to chemotherapy drugs.', 'In the current study, this strategy was expanded to the in-vitro genome-wide association approach, using 516 LCLs derived from a White cohort to asse... | qiaojin/PubMedQA | 2 | [
-2.3417441844940186,
-1.2818961143493652,
2.700141668319702
] |
['Low-frequency heart rate variability (LF-HRV) at rest has already been successfully modeled as self-sustained oscillations in a nonlinear control loop, but these models fail to simulate LF-HRV decreases either during aerobic exercise or in heart failure patients. Following control engineering practices, we assume the... | qiaojin/PubMedQA | 2 | [
-2.516685724258423,
-0.5025612115859985,
2.1282143592834473
] |
['Genetic variation at 1p13 modulates serum lipid levels and the risk of coronary heart disease through the regulation of serum lipid levels. Here we investigate if the interaction between genetic variants at 1p13 and serum lipid levels affects the risk of non-fatal myocardial infarction (MI) in the Stockholm Heart Epi... | qiaojin/PubMedQA | 2 | [
-1.4858633279800415,
-1.6044652462005615,
2.1349809169769287
] |
['To determine the role of Notch signaling in corneal epithelial migration and wound healing.', 'Immunolocalization of Notch1 was performed during epithelial wound healing in vivo in mouse corneal epithelial debridement wounds and in vitro in primary human corneal epithelial cells following a linear scratch wound. The ... | qiaojin/PubMedQA | 2 | [
-2.4607326984405518,
-1.2431721687316895,
2.7275569438934326
] |
['Plasmodium falciparum-infected erythrocytes (IEs) adhere to host cell receptors, allowing parasites to sequester into deep vascular beds of various organs. This defining phenomenon of malaria pathogenesis is key to the severe clinical complications associated with cerebral and placental malaria. The principal ligand ... | qiaojin/PubMedQA | 2 | [
-2.5969951152801514,
-1.1392005681991577,
2.8724522590637207
] |
['This study examines if ischemic postconditioning is preserved in hypertrophied myocardium of spontaneously hypertensive rats (SHR).', 'Infarct sizes, hemodynamic, morphometric, and biochemical parameters were obtained from normotensive controls [Wistar-Kyoto (WKY) rats] and compared with SHRs. In open-chest rats, the... | qiaojin/PubMedQA | 2 | [
-2.2943038940429688,
-1.3534469604492188,
2.707720994949341
] |
['Hermansky-Pudlak syndrome (HPS) is a family of recessive disorders of intracellular trafficking defects that are associated with highly penetrant pulmonary fibrosis. Naturally occurring HPS mice reliably model important features of the human disease, including constitutive alveolar macrophage activation and susceptib... | qiaojin/PubMedQA | 2 | [
-2.4935672283172607,
-1.263035535812378,
2.828862190246582
] |
['The rates of nonunion after femoral nailing are currently reported to be 4.1-12.5 %. The purpose of this study was to identify the risk factors of noninfected nonunion after femoral nailing, focusing in particular on the effects of the length of the distal main fragment.', 'A case-control study was conducted with 105... | qiaojin/PubMedQA | 2 | [
-1.5248342752456665,
-1.538975477218628,
2.1754889488220215
] |
['This study aimed to compare recurrence and survival in patients undergoing either selective neck dissection or modified radical neck dissection to treat metastatic cutaneous head and neck squamous cell carcinoma to the cervical lymph nodes (levels I-V) only.', 'Twenty-eight year, retrospective analysis of a prospecti... | qiaojin/PubMedQA | 2 | [
-1.8770166635513306,
-1.038050651550293,
2.058976650238037
] |
['The FDA-approved dose of low-molecular-weight heparin (LMWH) may not provide adequate thromboprophylaxis in morbidly obese patients after total knee arthroplasty (TKA). Suboptimal dosing, delayed initiation, and overreliance on mechanical methods may also limit the effectiveness of thromboprophylaxis.', 'We explored ... | qiaojin/PubMedQA | 2 | [
-1.9704993963241577,
-1.4469671249389648,
2.423375368118286
] |
['To gain new insights into the molecular mechanisms of action of doxazosin, we investigated the prostatic stroma ultrastructure and the expression of genes involved with fibrosis, such as collagen type I and III (COL1A1 and COL3A1, respectively) and TGF-beta 1, in the rat ventral prostate.', 'Adult Wistar rats were tr... | qiaojin/PubMedQA | 2 | [
-2.43338680267334,
-1.3001986742019653,
2.744622230529785
] |
['Platelet transfusions are performed almost entirely according to expert experience. This study assessed the effectiveness of a restrictive guideline to reduce platelet transfusions in preterm infants.', 'A retrospective cohort of preterm infants with a birth weight of <1500 g had been born in 2 periods. In Period 1, ... | qiaojin/PubMedQA | 2 | [
-1.5568796396255493,
-0.9749261140823364,
1.5609110593795776
] |
['To study the post-natal characteristics and the survival of offspring derived from DNA damaged sperm.', 'This experimental prospective study was conducted on Swiss Albino mice (Mus musculus). Sperm DNA damage was induced by different doses of γ-irradiation in male mice who were then mated with healthy female mice. Th... | qiaojin/PubMedQA | 2 | [
-2.620356321334839,
0.788802444934845,
0.921131432056427
] |
['Autoantigen presentation by HLA-DR molecules is thought to be a central component of many autoimmune diseases, but identifying disease-relevant autoantigens has been a difficult challenge. In this study we aimed to identify autoantigens in patients with antibiotic-refractory Lyme arthritis, in which infection-induced... | qiaojin/PubMedQA | 2 | [
-2.3164327144622803,
-1.3208024501800537,
2.7181544303894043
] |
['\u2002 Nestin (a neuronal stem cell/progenitor cell marker of central nervous system development), vimentin (which is ubiquitously expressed in mesenchymal cells), and the glucocorticoid receptor (GR, which is involved in the immune response, cell proliferation, and apoptosis) have been shown to interact in embryonic... | qiaojin/PubMedQA | 2 | [
-2.2796952724456787,
-1.4144291877746582,
2.747191905975342
] |
['Knowledge about signaling pathways in malignant cells may provide prognostic and diagnostic information in addition to identify potential molecular targets for therapy. B-cell receptor (BCR) and co-receptor CD40 signaling is essential for normal B cells, and there is increasing evidence that signaling via BCR and CD4... | qiaojin/PubMedQA | 2 | [
-2.3837993144989014,
-1.353097915649414,
2.7808120250701904
] |
["While obesity may increase the risk for neurodegenerative diseases such as Alzheimer's disease, the relationship between waist circumference (WC) and central auditory dysfunction is unknown. We aimed to investigate the relationship of WC and pitch pattern sequence (PPS) score in adults.", 'The association of WC with ... | qiaojin/PubMedQA | 2 | [
-1.9616999626159668,
-0.7561201453208923,
1.8110160827636719
] |
['The presence of disease-specific autoantibodies in RA but not spondyloarthritis (SpA) suggests that B-cell tolerance is preserved in the latter condition despite chronic joint inflammation. Which factors control B-cell tolerance vs autoimmunity in chronic arthritis remains incompletely understood. As single nucleotid... | qiaojin/PubMedQA | 2 | [
-2.2752835750579834,
-1.3463820219039917,
2.664748191833496
] |
['Obesity has become a major epidemic in the United States. Although research suggests obesity does not increase major morbidity or mortality after thoracic operations, it likely results in greater use of health care resources.', 'We examined all patients in The Society of Thoracic Surgeons General Thoracic Surgery dat... | qiaojin/PubMedQA | 2 | [
-0.8151519298553467,
-1.422936201095581,
1.2638647556304932
] |
['β-Blockers are known to improve survival of patients with cardiovascular disease, but their administration in patients with chronic obstructive pulmonary disease (COPD) remains controversial. The aim of the present study was to assess the effect of β-blocker administration in patients with COPD undergoing coronary ar... | qiaojin/PubMedQA | 2 | [
-1.564819097518921,
-1.5043630599975586,
1.9840810298919678
] |
['To assess whether the fasting glucose level on admission, day 14 or their variation in patients with aSAH was associated with 1-year mortality.', 'A prospective study was undertaken to analyze the effects of fasting glucose on admission, day 14 and their variation on the 1-year mortality rate after aSAH. Patients wit... | qiaojin/PubMedQA | 2 | [
-1.0276803970336914,
-1.4155874252319336,
1.4134870767593384
] |
['TIMP1 (tissue inhibitor of metalloproteinases 1) regulates extracellular matrix turnover and also promotes cell growth and has anti-apoptotic activity, which promotes malignant processes in tumor tissue. The aim of our study was to evaluate the relation of plasma TIMP1 protein levels with prognosis in patients with l... | qiaojin/PubMedQA | 2 | [
-2.285942316055298,
-1.0547668933868408,
2.4107553958892822
] |
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