sot_question stringlengths 42 9.8k | ds_name stringclasses 8
values | pred_label int64 0 2 | logits listlengths 3 3 |
|---|---|---|---|
['To determine impediments to the effective reduction of maternal-infant transmission of HIV in the municipality of Campos dos Goytacazes, RJ, Brazil.', 'This is a cohort study, with medical follow-up, of pregnant women with confirmed diagnosis of HIV infection, and their infant children, assisted at the Municipal Spec... | qiaojin/PubMedQA | 2 | [
-2.3209712505340576,
-0.5125288963317871,
2.0216009616851807
] |
['Motor cortex excitability can be measured by transcranial magnetic stimulation (TMS) using different coil types, but paired-TMS was originally devised with a figure-of-eight coil. We asked whether the most popular, circular coil was suited to the every-day assessment of cortical excitability, particularly paired-TMS ... | qiaojin/PubMedQA | 2 | [
-1.3685340881347656,
-1.4373656511306763,
1.8866673707962036
] |
['The anti-cancer effect of β-lapachone (β-lap) is positively related to the cellular activity of NAD(P)H:quinone oxidoreductase (NQO1). Heat shock has been reported to elevate cellular NQO1. The effect of heating on the NQO1 expression in human osteosarcoma cells (HOS) and the response of the cells to the combined tre... | qiaojin/PubMedQA | 2 | [
-2.5015060901641846,
-1.237645149230957,
2.7256996631622314
] |
['Recent studies suggest that large (>1 cm) diameter circular cutaneous wounds induce follicular neogenesis in mice. However, the effects of non-circular wounds or smaller circular wounds on the hair follicle cycle remain poorly understood.', 'We investigated whether non-circular wounds or smaller (≤1 cm) circular woun... | qiaojin/PubMedQA | 2 | [
-2.2729909420013428,
-1.313692569732666,
2.647787570953369
] |
['Pilot study to examine if the addition of a structured framework improved the quality of clinical reasoning demonstrated within clinically based online discussions by occupational therapy students undertaking fieldwork.', "Cognitive elements of the clinical reasoning process present within students' discussions were ... | qiaojin/PubMedQA | 1 | [
-2.1321465969085693,
2.482036828994751,
-1.0191521644592285
] |
["Individual and workplace barriers affect uptake of evidence-based practice (EBP). This study evaluated the effects of a 1-day workshop with workplace supports on allied health professionals' EBP knowledge and behaviour.", 'A prospective longitudinal pre-post design was used. A total of 88 allied health professionals ... | qiaojin/PubMedQA | 2 | [
-1.036155343055725,
-0.4524867832660675,
0.6368664503097534
] |
['Studies conducted in the USA have demonstrated that micronutrients such as folate and vitamin B12 play a significant role in modifying the natural history of high-risk human papillomaviruses (HR-HPVs), the causative agent for developing invasive cervical cancer (CC) and its precursor lesions.', 'The purpose of the cu... | qiaojin/PubMedQA | 2 | [
-1.8904714584350586,
-1.287527084350586,
2.1983816623687744
] |
['Administration of caffeine or caffeinated coffee in laboratory and ambulatory settings results in small to moderate acute increases in blood pressure (BP). However, habitual coffee intake has not been linked conclusively to long-term increases in basal BP, and findings are inconsistent by sex. This study examined lon... | qiaojin/PubMedQA | 2 | [
-2.371567487716675,
-0.8078744411468506,
2.2638392448425293
] |
['Polyphenols in red wine are supposed to improve endothelial function. We investigated whether daily red wine consumption improves in-vivo vascular function by reducing endothelin-1 (ET-1). Additional pathways mediating this effect were studied using porcine coronary arteries (PCAs).', 'Eighteen young healthy women dr... | qiaojin/PubMedQA | 2 | [
-2.501065492630005,
-1.2668907642364502,
2.8029377460479736
] |
['Internal hernia (IH) is one of the more acute and potentially devastating complications after laparoscopic gastric bypass (LGB). Currently, there is no way to predict which patients will develop IH. We propose that patients who undergo periods of rapid excess weight loss (EWL) following LGB are more likely to develop... | qiaojin/PubMedQA | 2 | [
-1.427407145500183,
-1.6751161813735962,
2.0624938011169434
] |
['Statins exert regression of left ventricular hypertrophy independent of their plasma cholesterol-lowering actions. However, the underlying mechanism is not clear.', 'We tested the hypothesis that the extracellular signal-regulated kinases (ERKs) signaling pathway could be a target of simvastatin (SIM) and involved in... | qiaojin/PubMedQA | 2 | [
-2.085340738296509,
-1.4352248907089233,
2.5059103965759277
] |
['Outer hair cells are the specialized sensory cells that empower the mammalian hearing organ, the cochlea, with its remarkable sensitivity and frequency selectivity. Sound-evoked receptor potentials in outer hair cells are shaped by both voltage-gated K(+) channels that control the membrane potential and also ligand-g... | qiaojin/PubMedQA | 2 | [
-2.631852388381958,
-0.9682915806770325,
2.6334075927734375
] |
['We undertook to improve an industrial Saccharomyces cerevisiae strain by derepressing it for maltose utilization in the presence of high glucose concentrations.', 'A mutant was obtained from an industrial S. cerevisiae strain following random UV mutagenesis and selection on maltose/5-thioglucose medium. The mutant ac... | qiaojin/PubMedQA | 2 | [
-2.585371255874634,
-0.9691968560218811,
2.6349904537200928
] |
['Gold nanoparticles are of interest as potential in vivo diagnostic and therapeutic agents, as X-ray contrast agents, drug delivery vehicles and radiation enhancers. The aim of this study was to quantitatively determine their targeting and microlocalisation in mouse tumour models after intravenous injection by using m... | qiaojin/PubMedQA | 2 | [
-1.9206820726394653,
-1.5414679050445557,
2.490267276763916
] |
['The decline of proteasomal activity is known to be associated with the age-related disorders but the early events involved in this process are not apparent. To address this, we investigated the early-age-related (pediatric vs. adult) mechanisms that augment immunopathogenesis of sepsis and acute lung injury.', 'The 3... | qiaojin/PubMedQA | 2 | [
-2.4577982425689697,
-1.2847464084625244,
2.8065264225006104
] |
['Low-dose aspirin reduces cardiovascular risk; however, monitoring over-the-counter medication use relies on the time-consuming and costly manual review of medical records. Our objective is to validate natural language processing (NLP) of the electronic medical record (EMR) for extracting medication exposure and contr... | qiaojin/PubMedQA | 2 | [
-1.6634494066238403,
-1.144293189048767,
1.9326553344726562
] |
['Suicidal behaviour aggregates in families and HPA-axis dysregulation may help explain part of this familial aggregation. Nevertheless, exogenous manipulation of the HPA-axis has yielded mixed results. Naturalistic and non-pharmacological inductions of the HPA-axis do not suggest hyper-responsiveness, yet suggest grea... | qiaojin/PubMedQA | 2 | [
-2.443073034286499,
-0.851405918598175,
2.3790841102600098
] |
['In order to investigate the diversity of oil-degrading bacteria in the surface seawater across the India Ocean, and to obtain new oil-degrading bacteria.', 'Potential oil-degrading bacteria were selected out via 1:1 mixture of diesel and crude oil as sole carbon source. Meanwhile, the community structure of 13 enrich... | qiaojin/PubMedQA | 2 | [
-2.557440996170044,
0.6848896145820618,
1.1115329265594482
] |
['To compare the predictive values of axillary ultrasound (US) combined with fine needle aspiration (FNA) cytology with tumour size (T stage) and grade in the preoperative staging of breast cancer. More precise definition of axillary FNA reporting nomenclature is also presented.', '314 patients: 119 patients had suspic... | qiaojin/PubMedQA | 2 | [
-1.826226830482483,
-1.239020824432373,
2.140845775604248
] |
['In human epidermal keratinocytes the expression of hsp27 is closely related to differentiation in vitro and in situ.', 'We aimed to gain further insight into the role of hsp27 in epidermal differentiation by specific inhibition through siRNA and inhibition of p38-MAPK, the key enzyme of hsp27 phosphorylation.', 'Norm... | qiaojin/PubMedQA | 2 | [
-2.455869197845459,
-1.183990240097046,
2.6723971366882324
] |
['Advanced biliary tract carcinomas (BTCs) have poor prognosis and limited therapeutic options. Therefore, it is crucial to combine standard therapies with molecular targeting. In this study EGFR, HER2, and their molecular transducers were analysed in terms of mutations, amplifications and over-expression in a BTC case... | qiaojin/PubMedQA | 2 | [
-1.9745032787322998,
-1.5310630798339844,
2.5221447944641113
] |
['Sigma-2 receptors are over-expressed in proliferating cancer cells, making an attractive target for the targeted treatment of pancreatic cancer. In this study, we investigated the role of the novel sigma-2 receptor ligand SW43 to induce apoptosis and augment standard chemotherapy.', 'The binding affinity for sigma-2 ... | qiaojin/PubMedQA | 2 | [
-2.3012983798980713,
-1.0863059759140015,
2.42718768119812
] |
['Oxidative injury can cause renal function impairment and failure. Glutathione, a free radical scavenger, plays in the kidney a central role in oxidant-related events. The aim of this study was to investigate the potential beneficial effect of glutamine, a precursor of glutathione in the form of alanine-glutamine dipe... | qiaojin/PubMedQA | 2 | [
-2.584087371826172,
-1.1699833869934082,
2.841614246368408
] |
['Evolution of toxicity testing is predicated upon using in vitro cell based systems to rapidly screen and predict how a chemical might cause toxicity to an organ in vivo. However, the degree to which we can extend in vitro results to in vivo activity and possible mechanisms of action remains to be fully addressed.', '... | qiaojin/PubMedQA | 2 | [
-2.5248544216156006,
-0.6350082159042358,
2.2469940185546875
] |
['The prognostic role of C-reactive protein (CRP) in acute heart failure (HF) is not fully understood, and the impact of an infectious process in its risk-stratification power was not previously evaluated.', 'As CRP is an inflammatory marker, its prognostic value in acute HF is probably different in patients with and w... | qiaojin/PubMedQA | 2 | [
-1.0993605852127075,
-1.5386098623275757,
1.6593478918075562
] |
['This study was aimed at understanding the clinicopathological significance of cystatin M loss, and investigating possible factors responsible for cystatin M loss in breast cancer.', 'The expression of estrogen receptor (ER), progesterone receptor (PR), HER2, HER4, and cystatin M was retrospectively analyzed using imm... | qiaojin/PubMedQA | 2 | [
-1.7366126775741577,
-1.601792812347412,
2.3047690391540527
] |
['To investigate the role of recombinant human interleukin-11 (rhIL-11) on in vivo mobilization of CD34(+)/vascular endothelial growth factor receptor (VEGFR) 2(+) mononuclear cells and collateral vessel remodeling in a mouse model of hindlimb ischemia.', 'We observed that treatment of Sv129 mice with continuous infusi... | qiaojin/PubMedQA | 2 | [
-2.2842485904693604,
-1.3609097003936768,
2.645275354385376
] |
['Activating KRAS mutations are important for cancer initiation and progression; and have recently been shown to cause primary resistance to therapies targeting the epidermal growth factor receptor. Therefore, strategies are currently in development to overcome treatment resistance due to oncogenic KRAS. The hypoxia-in... | qiaojin/PubMedQA | 2 | [
-2.5629918575286865,
-0.9567703008651733,
2.590674638748169
] |
['Gallstones are common and contribute to morbidity and health care costs, but their effects on mortality are unclear. We examined whether gallstone disease was associated with overall and cause-specific mortalities in a prospective national population-based sample.', 'We analyzed data from 14,228 participants in the t... | qiaojin/PubMedQA | 2 | [
-0.9266377091407776,
-1.4119666814804077,
1.3674380779266357
] |
['Despite advancements in the provision of burn care, there is still a significant cohort of patients who fail to respond to therapy or for whom treatment is deemed futile. The decision to withdraw support from, or to implement a Do-Not-Resuscitate (DNAR) order in, such patients can be challenging. Our aims were to rev... | qiaojin/PubMedQA | 1 | [
-1.8376165628433228,
0.6250334978103638,
0.38217881321907043
] |
['Based on a report for one species (Scylla serrata), it is widely believed that mud crabs are relatively resistant to disease caused by white spot syndrome virus (WSSV). We tested this hypothesis by determining the degree of susceptibility in two species of mud crabs, Scylla olivacea and Scylla paramamosain, both of w... | qiaojin/PubMedQA | 2 | [
-0.2837020754814148,
-1.276307463645935,
0.609645426273346
] |
['Influenza A virus (IAV) infection markedly up-regulates ectopic trypsins in various organs, viral envelope glycoprotein processing proteases, which are pre-requisites for virus entry and multiplication. We investigated the pathological roles of trypsin up-regulation in the progression of IAV-induced myocarditis, cyto... | qiaojin/PubMedQA | 2 | [
-2.5494418144226074,
-1.2270042896270752,
2.8604044914245605
] |
['PKA is a ubiquitous, multi-subunit cellular kinase that regulates a number of different physiological responses in response to cAMP, including metabolism, cell division, and cardiac function. Numerous studies have implicated altered PKA signaling in cardiac dysfunction. Recently, it has been shown that mice lacking t... | qiaojin/PubMedQA | 2 | [
-2.5535359382629395,
-0.7755433320999146,
2.279395341873169
] |
["Numerous studies have reported that increased expression of S100B, an intracellular Ca2+ receptor protein and secreted neuropeptide, exacerbates Alzheimer's disease (AD) pathology. However, the ability of S100B inhibitors to prevent/reverse AD histopathology remains controversial. This study examines the effect of S1... | qiaojin/PubMedQA | 2 | [
-2.2790868282318115,
-1.3803895711898804,
2.6405930519104004
] |
['In HIV-positive individuals, complex multifactorial mechanisms control viral infection. In addition to viral and immunological factors, the host genetic background also plays an important role. Our objective was to evaluate how various genetic factors associated with delayed AIDS onset.', "Thirty HIV+ long-term nonpr... | qiaojin/PubMedQA | 2 | [
-2.1449501514434814,
-1.4029450416564941,
2.5889346599578857
] |
['Ropivacaine has an optimal toxicity profile for epidural anesthesia in adults, but there are currently no studies concerning its pharmacokinetics during continuous infusion. The primary objective of this study was to evaluate the pharmacokinetics and safety of ropivacaine in adults during a 48-h continuous epidural i... | qiaojin/PubMedQA | 2 | [
-1.1569864749908447,
-1.765613079071045,
1.9133167266845703
] |
['The SERPINA1, SERPINA3, and SERPINE2 genes, which encode antiproteases, have been proposed to be susceptible genes for of chronic obstructive pulmonary disease (COPD) and related phenotypes. Whether they are associated with emphysema is not known.', 'Twelve previously reported single nucleotide polymorphisms (SNPs) i... | qiaojin/PubMedQA | 2 | [
-1.3942934274673462,
-1.5422863960266113,
1.9299345016479492
] |
['Understanding organizational principles of cellular networks is one of the central goals of systems biology. Although much has been learnt about gene expression programs under specific conditions, global patterns of expressional variation (EV) of genes and their relationship to cellular functions and physiological re... | qiaojin/PubMedQA | 2 | [
-2.5612258911132812,
0.7202811241149902,
0.9909743070602417
] |
['The tumor suppressor genes p15(INK)⁴(b) and p16(INK)⁴(a) as well as the estrogen receptor-α (ESR1) gene are abnormally methylated and expressed in colon cancer. The cancer-preventative abilities of several bioactive food components have been linked to their estrogenic and epigenetic activities.', 'The effect of folic... | qiaojin/PubMedQA | 2 | [
-2.1030147075653076,
-1.509408712387085,
2.6146152019500732
] |
["Hypersensitivity Pneumonitis (HP) is an interstitial lung disease that occurs upon exposure to a variety of inhaled organic antigens. The presence of small non-caseating granulomas and isolated giant cells is not specific, but is considered a relevant histological feature for HP. The detection of granulomas is widely... | qiaojin/PubMedQA | 2 | [
-2.3421123027801514,
-1.4429349899291992,
2.8685779571533203
] |
['CD24 proteins are expressed on several inflammatory cells, and play an important role for the T-cell activation.', 'The aim of this study is to investigate the relationship of a CD24 gene polymorphism to disease susceptibility or clinical findings including bronchoalveolar lavage (BAL) cell profiles in Japanese sarco... | qiaojin/PubMedQA | 2 | [
-2.406566619873047,
-0.959653377532959,
2.3684256076812744
] |
['To assess the relationship between the degree of symptoms and defects caused by spina bifida and the quality of life (QoL) of children with spina bifida in Kenya.', 'Children with spina bifida at BethanyKids at Kijabe Hospital, at mobile clinics throughout Kenya and a control group of healthy children were interviewe... | qiaojin/PubMedQA | 1 | [
-1.9203664064407349,
0.546047568321228,
0.521653413772583
] |
['Delayed graft function (DGF) and slow graft function (SGF) due to ischemic and reperfusion injury (IRI) are common complications of deceased donor kidney transplantation. We tested whether a panel of serum and urine cytokines represent early biomarkers for DGF and SGF.', 'We collected serum and urine samples from 61 ... | qiaojin/PubMedQA | 2 | [
-2.286478281021118,
-1.4143314361572266,
2.8105483055114746
] |
['To compare the cationic antimicrobial peptide gene expression profiles and urinary cationic antimicrobial activities of patients after urinary diversion according to their urinary tract infection (UTI) status. Ileal conduit urinary diversion joins the bacterial-tolerant ileal epithelium and intolerant urothelium. Aft... | qiaojin/PubMedQA | 2 | [
-2.445208787918091,
-1.337131142616272,
2.8365869522094727
] |
['To evaluate the incidence of cardiovascular disease (CVD) among Greek patients with rheumatoid arthritis (RA) under medical followup, and to assess the contribution of traditional CVD and RA-specific factors associated with CVD development.', "This is a historic cohort study; information was collected from medical re... | qiaojin/PubMedQA | 2 | [
-2.330031156539917,
-0.7513910531997681,
2.2508201599121094
] |
['Loss-of-function mutations in human hepatocyte nuclear factor 4α (HNF4α) are associated with maturity-onset diabetes of the young and lipid disorders. However, the mechanisms underlying the lipid disorders are poorly understood. In this study, we determined the effect of acute loss or augmentation of hepatic HNF4α fu... | qiaojin/PubMedQA | 2 | [
-2.4490747451782227,
-1.3174099922180176,
2.7413792610168457
] |
['Aberrant activation of the RAS pathway is ubiquitous in human hepatocarcinogenesis, but the molecular mechanisms leading to RAS induction in the absence of RAS mutations remain under-investigated. We defined the role of Ras GTPase activating proteins (GAPs) in the constitutive activity of Ras signaling during human h... | qiaojin/PubMedQA | 2 | [
-2.384599208831787,
-1.2841620445251465,
2.6899209022521973
] |
['Titanium is widely used in contemporary endosseous implantology and there is considerable thrust to further promote osseointegration by implant surface modifications. The aim of this study was to evaluate the effect of a titanium-nitride-oxide (TiNOx) coating on commercially pure microroughened titanium by assessing ... | qiaojin/PubMedQA | 2 | [
-2.423649311065674,
-1.1400530338287354,
2.668145179748535
] |
['Reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) has been implicated in the attenuation of tumor metastasis by negatively regulating metalloproteinase (MMP) levels. RECK gene expression is downregulated in many solid tumors, with this downregulation being associated with poor prognosis. This study ev... | qiaojin/PubMedQA | 2 | [
-2.3089404106140137,
-1.4288561344146729,
2.7486932277679443
] |
['to investigate the effect of glycosylation modification on secretion of intein spliced B-domain-deleted FVIII (BDD-FVIII).', 'a total of 226 amino acid residues of FVIII B domain with six potential asparagines-linked glycosylation sites (N6) were incorporated into heavy chain of BDD-FVIII. By dual-vector co-transfer ... | qiaojin/PubMedQA | 2 | [
-1.5781992673873901,
-1.5675733089447021,
2.1757421493530273
] |
['microRNAs (miRNAs) are a class of non-coding, single-stranded RNA molecules that regulate gene expression at the posttranscriptional level. Methyl-CpG-binding domain proteins (MBPs) are transcription repressors through binding to methylated gene promoters. Recent studies have shown that the effect of miRNAs on DNA me... | qiaojin/PubMedQA | 2 | [
-2.3319756984710693,
-1.1956512928009033,
2.522355079650879
] |
['Volatiles emitted by herbivore-infested plants are highly attractive to parasitoids and therefore have been proposed to be part of an indirect plant defense strategy. However, this proposed function of the plant-provided signals remains controversial, and it is unclear how specific and reliable the signals are under ... | qiaojin/PubMedQA | 2 | [
-2.785386323928833,
0.10709376633167267,
1.6877415180206299
] |
['microsatellite instability (MSI) is commonly screened using a panel of two mononucleotide and three dinucleotide repeats as recommended by a consensus meeting on MSI tumours held at the National Cancer Institute (Bethesda, MD, USA). According to these recommendations, tumours are classified as MSI-H when at least two... | qiaojin/PubMedQA | 2 | [
-2.2581379413604736,
-1.213097333908081,
2.5728554725646973
] |
['The powerful emotion inducing properties of music are well-known, yet music may convey differing emotional responses depending on environmental factors. We hypothesized that neural mechanisms involved in listening to music may differ when presented together with visual stimuli that conveyed the same emotion as the mu... | qiaojin/PubMedQA | 2 | [
-2.04535174369812,
-0.847311794757843,
1.9137496948242188
] |
["The aim of this study was to test a new method for continuous monitoring of the Danish contact person concept and to evaluate the impact of the concept on the mothers' perception of nursing care and on their self-efficacy.", 'This is a descriptive study, carried out at a neonatal unit forming part of a department of ... | qiaojin/PubMedQA | 1 | [
-1.2844061851501465,
0.4017588198184967,
0.10581884533166885
] |
['Heart rate (HR) recovery (HRR), defined as the rate of decline in the HR immediately following the cessation of exercise, is influenced by autonomic function. Heart rate recovery in heart failure (HF) has been shown to correlate with severity of HF. Cardiac resynchronization therapy (CRT) improves cardiac autonomic f... | qiaojin/PubMedQA | 2 | [
-1.1376301050186157,
-1.6732982397079468,
1.8473349809646606
] |
['TWO CROWDING METRICS ARE OFTEN USED TO MEASURE EMERGENCY DEPARTMENT (ED) CROWDING: the occupancy rate and the emergency department work index (EDWIN) score. To evaluate these metrics for applicability in our community ED, we sought to measure their correlation with the number of patients who left without being seen (... | qiaojin/PubMedQA | 0 | [
0.42339402437210083,
-1.5351684093475342,
0.2359723150730133
] |
['Previous diffusion tensor imaging (DTI) studies have shown white matter compromise in children and adults with autism spectrum disorder (ASD), which may relate to reduced connectivity and impaired function of distributed networks. However, tract-specific evidence remains limited in ASD. We applied tract-based spatial... | qiaojin/PubMedQA | 2 | [
-2.39457631111145,
-1.1600220203399658,
2.6570606231689453
] |
['To evaluate the factors that influence the oral hygiene and the periodontal treatment needs of children and adolescents with coeliac disease (CD) in Greece.', 'The sample consisted of 35 children and adolescents, aged 4-18 years. The evaluation included consideration of the detailed medical history, the duration of C... | qiaojin/PubMedQA | 2 | [
-2.3345868587493896,
-0.40657520294189453,
1.9083738327026367
] |
['To examine the influence of intracoronary autologous bone marrow cell transplantation after acute myocardial infarction on circulating growth factors and their relationship to left ventricular function.', 'Circulating insulin-like growth factor-1 (IGF-1), hepatocyte growth factor (HGF), stromal derived factor-1-alpha... | qiaojin/PubMedQA | 2 | [
-2.0546000003814697,
-1.4629216194152832,
2.5297651290893555
] |
['The availability of larger-scale SNP data sets in the chicken genome allows to achieve a higher resolution of the pattern of linkage disequilibrium (LD). In this study, 36 k and 57 k genotypes from two independent genotyping chips were used to systematically characterize genome-wide extent and structure of LD in the ... | qiaojin/PubMedQA | 0 | [
0.34479546546936035,
-0.8561504483222961,
-0.40194207429885864
] |
['In recent years, the use of higher risk donor organs and steroid avoidance regimens with potential increased acute rejection risk have increased. We hypothesized that these patterns adversely affect changes in posttransplant renal function.', 'By using Scientific Registry of Transplant Recipients data and multivariab... | qiaojin/PubMedQA | 2 | [
-1.7745190858840942,
-1.4326517581939697,
2.2100167274475098
] |
['A 3-month course of prophylaxis is usually recommended for cytomegalovirus (CMV) D+/R- renal transplant recipients. Based on recent data, up to 6 months of prophylaxis may be used. A subanalysis was performed to evaluate the pharmacokinetics of ganciclovir after valganciclovir administration and to perform an explora... | qiaojin/PubMedQA | 2 | [
-2.1314351558685303,
-1.5057318210601807,
2.7066421508789062
] |
['Significant relationships have been reported between the uptake of mycophenolic acid (MPA) and the risk of acute rejection. In a prospective study after renal transplantation, we assessed the value of measuring inosine-monophosphate dehydrogenase (IMPDH) activity as a predictive indicator of an acute rejection episod... | qiaojin/PubMedQA | 2 | [
-1.8995006084442139,
-1.5698277950286865,
2.4639973640441895
] |
['Acteoside, an active phenylethanoid glycoside found in bitter tea and many medicinal plants, displays chemopreventive properties. The aim of our study was to determine the effect of acteoside on tumor invasion and migration; the possible mechanisms involved in this inhibition were investigated in human fibrosarcoma H... | qiaojin/PubMedQA | 2 | [
-2.4383487701416016,
-1.2878096103668213,
2.765839099884033
] |
['The aim of this study was to determine the effect of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR), an AMP-activated protein kinase (AMPK) activator, on monocarboxylate transporter 4 (MCT4) expression in rat skeletal muscle and a prototypic embryonal rhabdomyosarcoma cell line (RD cells).', 'We examined... | qiaojin/PubMedQA | 2 | [
-2.5004780292510986,
-1.0805450677871704,
2.6296937465667725
] |
['Comparative gene expression is commonly determined with reference to the expression of a housekeeping gene (HKG), the level of which is assumed to be unregulated. There are little data to date on the effect of disease on the expression of classic HKGs in hepatitis C virus (HCV)-infected human liver.', 'To identity HK... | qiaojin/PubMedQA | 2 | [
-2.4360954761505127,
-1.1534316539764404,
2.69693922996521
] |
['Current assays and tests that are used to determine the degree of immunosuppression in renal transplant recipients are suboptimal. The ImmuKnow assay (Cylex), a measure of intracellular CD4+ T cell ATP release proposed as a means to quantify cell-mediated immunity in transplant recipients, could be considered as a po... | qiaojin/PubMedQA | 2 | [
-1.5462347269058228,
-1.5161936283111572,
2.1066274642944336
] |
['The efflux of cellular cholesterol mediated by apolipoprotein (apo)A-I and ATP-binding cassette transporter A1 (ABCA1) is a major pathway of reverse cholesterol transport. We investigated the effect of aspirin on this process.', 'The expression levels of ABCA1 in RAW264.7 cells were determined using reverse transcrip... | qiaojin/PubMedQA | 2 | [
-2.213468313217163,
-1.2714259624481201,
2.425973415374756
] |
["Identification of high-risk malaria foci can help enhance surveillance or control activities in regions where they are most needed. Associations between malaria risk and land-use/land-cover are well-recognized, but these environmental characteristics are closely interrelated with the land's topography (e.g., hills, v... | qiaojin/PubMedQA | 2 | [
-2.2484066486358643,
0.7238515019416809,
0.7642501592636108
] |
['To better define the nature of the transient neutropenia shortly following granulocyte-colony stimulating factor (G-CSF) administration.', 'To evaluate the disappearance of neutrophils, we investigated neutrophil trafficking. Ratios of neutrophil number to background cellularity for C57BL/6 LysM-EGFP knock-in mice an... | qiaojin/PubMedQA | 2 | [
-2.2609639167785645,
-1.2504643201828003,
2.512619733810425
] |
['Congestive heart failure (CHF) has a strong negative prognostic impact in patients with non-ST-elevation acute coronary syndromes (NSTE-ACS). The purpose of this study was to establish the effect of myocardial revascularization on prognosis in this setting.', 'We retrospectively studied 648 patients admitted with NST... | qiaojin/PubMedQA | 2 | [
-1.2664471864700317,
-1.707619309425354,
1.8712890148162842
] |
['To evaluate digital flexor tendon sheath (DFTS) synovial fluid cartilage oligomeric matrix protein (COMP) concentrations as a molecular marker for intrathecal pathology.', 'Case control study.', 'Horses (n=46) with DFTS tenosynovitis; 23 fresh cadaver horses.', 'DFTS synovial fluid samples were collected from clinica... | qiaojin/PubMedQA | 2 | [
-2.384981632232666,
-1.2917745113372803,
2.775759220123291
] |
['We characterized key intercostal anatomical relationships relevant to supracostal percutaneous nephrostolithotomy using anatomical dissection.', 'We performed 20 cadaveric dissections of the 11th intercostal space to characterize key anatomical relationships relevant to percutaneous upper pole renal access. Specific ... | qiaojin/PubMedQA | 2 | [
-2.155879259109497,
-0.8257840275764465,
2.1054952144622803
] |
['The action of serotonin (5-HT) at the 5-HT(2A) receptor subtype is thought to be involved in cocaine-seeking behavior that is motivated by exposure to drug-associated cues and drug priming. 5-HT(2A) receptors are densely clustered in the ventromedial prefrontal cortex (vmPFC), an area that plays a role in mediating c... | qiaojin/PubMedQA | 2 | [
-2.2330448627471924,
-1.223427653312683,
2.449270248413086
] |
["The phosphatase PTEN governs the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway which is arguably the most important pro-survival pathway in neurons. Recently, PTEN has also been implicated in multiple important CNS functions such as neuronal differentiation, plasticity, injury and drug addiction. It has been... | qiaojin/PubMedQA | 2 | [
-2.5049593448638916,
-1.1267075538635254,
2.657122850418091
] |
['There is worldwide debate about the appropriateness of caesarean sections performed without medical indications. In this analysis, we aim to further investigate the relationship between caesarean section without medical indication and severe maternal outcomes.', "This is a multicountry, facility-based survey that use... | qiaojin/PubMedQA | 2 | [
-1.8141810894012451,
-1.2180449962615967,
2.150242328643799
] |
['Phenotypic heterogeneity may ensure that a small fraction of a population survives environmental perturbations or may result in lysis in a subpopulation, to increase the survival of siblings. Genes involved in DNA repair and population dynamics play key roles in rapid responses to environmental conditions. In Escheri... | qiaojin/PubMedQA | 2 | [
-2.5483767986297607,
-0.8204249143600464,
2.4166641235351562
] |
["The loss of noradrenergic neurones of the locus coeruleus is a major feature of Alzheimer's disease (AD). Dopamine β-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline. Interactions have been reported between the low-activity -1021T allele (rs1611115) of DBH and polymorphisms of the pro-inflammat... | qiaojin/PubMedQA | 2 | [
-1.7799428701400757,
-1.5029315948486328,
2.181788444519043
] |
['Transactive response DNA-binding protein 43 (TDP-43) is the pathological protein found in frontotemporal lobar degeneration with ubiquitin positive inclusions and in amyotrophic lateral sclerosis. In diseased tissue, TDP-43 translocates from its physiological nuclear location into the cytoplasm, where it accumulates.... | qiaojin/PubMedQA | 2 | [
-2.5038881301879883,
-1.1152007579803467,
2.5998189449310303
] |
["Dyskinesias associated with involuntary movements and painful muscle contractions are a common and severe complication of standard levodopa (L-DOPA, L-3,4-dihydroxyphenylalanine) therapy for Parkinson's disease. Pathologic neuroplasticity leading to hyper-responsive dopamine receptor signaling in the sensorimotor str... | qiaojin/PubMedQA | 2 | [
-2.467461347579956,
-1.3271833658218384,
2.8399884700775146
] |
['Pathological bolus exposure is defined in the present study as cases in which all reflux percentage times are above 1.4% of the total reflux number, as revealed by impedance-pH monitoring. The role of pathological bolus exposure in the pathogenesis of non-cardiac chest pain (NCCP) is poorly known. We aimed to classif... | qiaojin/PubMedQA | 2 | [
-1.7414559125900269,
-1.5651886463165283,
2.29067325592041
] |
['The incidence of gallbladder stones is higher in women during pregnancy than in men. Progesterone can inhibit gallbladder motility and facilitate gallstone formation. However, the ionic mechanisms have not been fully illuminated. This study sought to investigate the effects of progesterone on L-type calcium currents ... | qiaojin/PubMedQA | 2 | [
-2.6399214267730713,
-0.9431307911872864,
2.6119909286499023
] |
['Contemporary medications used in the treatment of gastric ulcers involve the use of novel mucosal protective drugs. The present study aimed to investigate the gastroprotective effect of ginger extract and polaprezinc in a rat model of acetic acid-induced gastric ulcer.', "'Kissing' ulcers were induced in male Sprague... | qiaojin/PubMedQA | 2 | [
-2.427647829055786,
-1.2385741472244263,
2.6892993450164795
] |
['Human embryonic stem cell-derived RPE (hES-RPE) transplantation is a promising therapy for atrophic age-related macular degeneration (AMD); however, future therapeutic approaches may consider co-transplantation of hES-RPE with retinal progenitor cells (RPCs) as a replacement source for lost photoreceptors. The purpos... | qiaojin/PubMedQA | 2 | [
-2.390549421310425,
-1.3814101219177246,
2.8285329341888428
] |
['A drug eluting stent is often used for high-risk patients with complications such as diabetes mellitus (DM) and hemodialysis (HD), however the factors to predict restenosis after paclitaxel-eluting stent (PES) placement have not been reported to date.', 'Between May 2007 and August 2009, 165 consecutive patients (231... | qiaojin/PubMedQA | 2 | [
-1.512270450592041,
-1.6779091358184814,
2.195709466934204
] |
['The Pulmonary Embolism Rule-out Criteria (PERC) rule is a clinical diagnostic rule designed to exclude pulmonary embolism (PE) without further testing. We sought to externally validate the diagnostic performance of the PERC rule alone and combined with clinical probability assessment based on the revised Geneva score... | qiaojin/PubMedQA | 2 | [
-0.5445376038551331,
-1.420872449874878,
1.1058520078659058
] |
['Studies on the role of neutrophils in Leishmania infection were mainly performed with L. (L) major, whereas less information is available for L. (L) amazonensis. Previous results from our laboratory showed a large infiltrate of neutrophils in the site of infection in a mouse strain resistant to L. (L.) amazonensis (C... | qiaojin/PubMedQA | 2 | [
-2.7199783325195312,
-0.7534345984458923,
2.5681166648864746
] |
['The complement-dependent microcytotoxicity crossmatch (CDCXM) is a standard method for evaluating the presence of preformed antibodies before transplantation. The flow cytometry crossmatch (FCXM) is more sensitive, but there is controversy regarding translation of its increased sensitivity to clinically relevant graf... | qiaojin/PubMedQA | 2 | [
-1.7616523504257202,
-1.5686670541763306,
2.3655664920806885
] |
['Coronary artery bypass grafting (CABG) is linked to the induction of the blood coagulation/fibrinolysis cascade, which is an integral component of inflammation induced by cardiac surgery. We followed the modulation of urokinase plasminogen activator receptor uPAR (CD87) separately for monocytes and granulocytes in bl... | qiaojin/PubMedQA | 2 | [
-2.10681414604187,
-1.4931997060775757,
2.6369285583496094
] |
['The goal was to determine the number of breaths required to inhale salbutamol from different spacers/valved holding chambers (VHCs).', 'Breathing patterns were recorded for 2- to 7-year-old children inhaling placebo from 4 different spacers/VHCs and were simulated by a flow generator. Drug delivery with different num... | qiaojin/PubMedQA | 2 | [
-1.3624387979507446,
-0.9722822308540344,
1.3732142448425293
] |
['To investigate the relation between ponderal index or birth weight and insulin resistance in late childhood.', 'An observational study of 92-term appropriate-for-gestational age infants was carried out. Weight and length were measured at birth and at 9 months and duration of breast feeding was noted at 9 months. Foll... | qiaojin/PubMedQA | 2 | [
-0.5738471746444702,
-1.366687297821045,
1.081679105758667
] |
['To evaluate the effects of 25-Hz deep brain stimulation of the nucleus tegmenti pedunculopontini (PPTg) on brain metabolic activity.', "Six patients with Parkinson's disease (PD) who had bilateral stereotactic implantation of PPTg at least 12 months prior to evaluation were included in our study. All underwent, in se... | qiaojin/PubMedQA | 2 | [
-2.3083760738372803,
-1.3724561929702759,
2.701091766357422
] |
['To report on the histopathologic findings of affected skin in consecutively collected biopsy specimens from 49 patients with erythromelalgia (EM).', 'Skin biopsy specimens were obtained from the foot arch and analyzed by light microscopy, immunofluorescence microscopy, and electron microscopy.', 'Oslo University Hosp... | qiaojin/PubMedQA | 2 | [
-2.364269971847534,
-1.2404701709747314,
2.679779529571533
] |
['Insulin secretion is a complex and highly regulated process. It is well established that cytoplasmic calcium is a key regulator of insulin secretion, but how elevated intracellular calcium triggers insulin granule exocytosis remains unclear, and we have only begun to define the identities of proteins that are respons... | qiaojin/PubMedQA | 2 | [
-2.3757503032684326,
-1.1374081373214722,
2.5412728786468506
] |
["The human sex hormone-binding globulin (SHBG) gene comprises at least 6 different transcription units (TU-1, -1A, -1B, -1C, -1D and -1E), and is regulated by no less than 6 different promoters. The best characterized are TU-1 and TU-1A: TU-1 is responsible for producing plasma SHBG, while TU-1A is transcribed and tra... | qiaojin/PubMedQA | 2 | [
-2.033759117126465,
-1.247633695602417,
2.316405773162842
] |
["Ginseng, the root of Panax ginseng C.A. Meyer, is one of the most commonly used healing herbs for stroke and chronic debilitating conditions in China. Ginsenosides are the main active principles for ginseng's efficacy, but the mechanisms have not been fully clarified.", 'To test the hypothesis whether or not the admi... | qiaojin/PubMedQA | 2 | [
-2.018336534500122,
-1.4439198970794678,
2.4323065280914307
] |
['MMP-1 is over-expressed in many cancers, with high expression often associated with poor survival. In the present study, we examined the expression of MMP-1 in EOC and its role in EOC invasion. Moreover, we evaluated the role of a newly identified MMP-1-protease activated receptor (PAR)-1 axis in LPA-induced EOC inva... | qiaojin/PubMedQA | 2 | [
-2.135232448577881,
-1.453320860862732,
2.604200839996338
] |
['The effectiveness of cardiac rehabilitation (CR) in patients with coronary artery disease (CAD) is moderated by negative emotions and clinical factors, but no studies evaluated the role of positive emotions. This study examined whether anhedonia (i.e. the lack of positive affect) moderated the effectiveness of CR on ... | qiaojin/PubMedQA | 2 | [
-0.8932768106460571,
-1.3581894636154175,
1.2835485935211182
] |
['Morin (2′,3,4′,5,7-pentahydroxyflavone), a plant-derived flavonoid, has beneficial effects on hyperuricemia and renal dysfunction in animals. Since the decreased renal excretion of uric acid is the hallmark of hyperuricemia, here we studied the effects of oral morin administration on renal organic ion transporters in... | qiaojin/PubMedQA | 2 | [
-2.5210206508636475,
-1.2733560800552368,
2.819676160812378
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.