accession
stringlengths 6
10
| name
stringlengths 8
11
| Full Name
stringlengths 2
102
⌀ | taxon
stringclasses 1
value | sequence
stringlengths 48
2.3k
| function
stringlengths 15
1.34k
| AlphaFoldDB
stringlengths 6
10
|
|---|---|---|---|---|---|---|
A0JLT2
|
MED19_HUMAN
|
Mediator complex subunit 19
|
Homo
|
<M><E><N><F><T><A><L><F><G><A><Q><A><D><P><P><P><P><P><T><A><L><G><F><G><P><G><K><P><P><P><P><P><P><P><P><A><G><G><G><P><G><T><A><P><P><P><T><A><A><T><A><P><P><G><A><D><K><S><G><A><G><C><G><P><F><Y><L><M><R><E><L><P><G><S><T><E><L><T><G><S><T><N><L><I><T><H><Y><N><L><E><Q><A><Y><N><K><F><C><G><K><K><V><K><E><K><L><S><N><F><L><P><D><L><P><G><M><I><D><L><P><G><S><H><D><N><S><S><L><R><S><L><I><E><K><P><P><I><L><S><S><S><F><N><P><I><T><G><T><M><L><A><G><F><R><L><H><T><G><P><L><P><E><Q><C><R><L><M><H><I><Q><P><P><K><K><K><N><K><H><K><H><K><Q><S><R><T><Q><D><P><V><P><P><E><T><P><S><D><S><D><H><K><K><K><K><K><K><K><E><E><D><P><D><R><K><R><K><K><K><E><K><K><K><K><K><N><R><H><S><P><D><H><P><G><M><G><S><S><Q><A><S><S><S><S><S><L><R>
|
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<BOP>
|
A0JLT2
|
Q9ULZ3
|
ASC_HUMAN
|
Target of methylation-induced silencing 1
|
Homo
|
<M><G><R><A><R><D><A><I><L><D><A><L><E><N><L><T><A><E><E><L><K><K><F><K><L><K><L><L><S><V><P><L><R><E><G><Y><G><R><I><P><R><G><A><L><L><S><M><D><A><L><D><L><T><D><K><L><V><S><F><Y><L><E><T><Y><G><A><E><L><T><A><N><V><L><R><D><M><G><L><Q><E><M><A><G><Q><L><Q><A><A><T><H><Q><G><S><G><A><A><P><A><G><I><Q><A><P><P><Q><S><A><A><K><P><G><L><H><F><I><D><Q><H><R><A><A><L><I><A><R><V><T><N><V><E><W><L><L><D><A><L><Y><G><K><V><L><T><D><E><Q><Y><Q><A><V><R><A><E><P><T><N><P><S><K><M><R><K><L><F><S><F><T><P><A><W><N><W><T><C><K><D><L><L><L><Q><A><L><R><E><S><Q><S><Y><L><V><E><D><L><E><R><S>
|
Seems to inhibit inflammasome-mediated maturation of interleukin-1 beta.<BOP>
|
Q9ULZ3
|
Q9UBY8
|
CLN8_HUMAN
|
Protein CLN8
|
Homo
|
<M><N><P><A><S><D><G><G><T><S><E><S><I><F><D><L><D><Y><A><S><W><G><I><R><S><T><L><M><V><A><G><F><V><F><Y><L><G><V><F><V><V><C><H><Q><L><S><S><S><L><N><A><T><Y><R><S><L><V><A><R><E><K><V><F><W><D><L><A><A><T><R><A><V><F><G><V><Q><S><T><A><A><G><L><W><A><L><L><G><D><P><V><L><H><A><D><K><A><R><G><Q><Q><N><W><C><W><F><H><I><T><T><A><T><G><F><F><C><F><E><N><V><A><V><H><L><S><N><L><I><F><R><T><F><D><L><F><L><V><I><H><H><L><F><A><F><L><G><F><L><G><C><L><V><N><L><Q><A><G><H><Y><L><A><M><T><T><L><L><L><E><M><S><T><P><F><T><C><V><S><W><M><L><L><K><A><G><W><S><E><S><L><F><W><K><L><N><Q><W><L><M><I><H><M><F><H><C><R><M><V><L><T><Y><H><M><W><W><V><C><F><W><H><W><D><G><L><V><S><S><L><Y><L><P><H><L><T><L><F><L><V><G><L><A><L><L><T><L><I><I><N><P><Y><W><T><H><K><K><T><Q><Q><L><L><N><P><V><D><W><N><F><A><Q><P><E><A><K><S><R><P><E><G><N><G><Q><L><L><R><K><K><R><P>
|
Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.<BOP>
|
Q9UBY8
|
Q9H3C7
|
GGNB2_HUMAN
|
Protein ZNF403
|
Homo
|
<M><A><R><L><V><A><V><C><R><D><G><E><E><E><F><P><F><E><R><R><Q><I><P><L><Y><I><D><D><T><L><T><M><V><M><E><F><P><D><N><V><L><N><L><D><G><H><Q><N><N><G><A><Q><L><K><Q><F><I><Q><R><H><G><M><L><K><Q><Q><D><L><S><I><A><M><V><V><T><S><R><E><V><L><S><A><L><S><Q><L><V><P><C><V><G><C><R><R><S><V><E><R><L><F><S><Q><L><V><E><S><G><N><P><A><L><E><P><L><T><V><G><P><K><G><V><L><S><V><T><R><S><C><M><T><D><A><K><K><L><Y><T><L><F><Y><V><H><G><S><K><L><N><D><M><I><D><A><I><P><K><S><K><K><N><K><R><C><Q><L><H><S><L><D><T><H><K><P><K><P><L><G><G><C><W><M><D><V><W><E><L><M><S><Q><E><C><R><D><E><V><V><L><I><D><S><S><C><L><L><E><T><L><E><T><Y><L><R><K><H><R><F><C><T><D><C><K><N><K><V><L><R><A><Y><N><I><L><I><G><E><L><D><C><S><K><E><K><G><Y><C><A><A><L><Y><E><G><L><R><C><C><P><H><E><R><H><I><H><V><C><C><E><T><D><F><I><A><H><L><L><G><R><A><E><P><E><F><A><G><G><R><R><E><R><H><A><K><T><I><D><I><A><Q><E><E><V><L><T><C><L><G><I><H><L><Y><E><R><L><H><R><I><W><Q><K><L><R><A><E><E><Q><T><W><Q><M><L><F><Y><L><G><V><D><A><L><R><K><S><F><E><M><T><V><E><K><V><Q><G><I><S><R><L><E><Q><L><C><E><E><F><S><E><E><E><R><V><R><E><L><K><Q><E><K><K><R><Q><K><R><K><N><R><R><K><N><K><C><V><C><D><I><P><T><P><L><Q><T><A><D><E><K><E><V><S><Q><E><K><E><T><D><F><I><E><N><S><S><C><K><A><C><G><S><T><E><D><G><N><T><C><V><E><V><I><V><T><N><E><N><T><S><C><T><C><P><S><S><G><N><L><L><G><S><P><K><I><K><K><G><L><S><P><H><C><N><G><S><D><C><G><Y><S><S><S><M><E><G><S><E><T><G><S><R><E><G><S><D><V><A><C><T><E><G><I><C><N><H><D><E><H><G><D><D><S><C><V><H><H><C><E><D><K><E><D><D><G><D><S><C><V><E><C><W><A><N><S><E><E><N><D><T><K><G><K><N><K><K><K><K><K><K><S><K><I><L><K><C><D><E><H><I><Q><K><L><G><S><C><I><T><D><P><G><N><R><E><T><S><G><N><T><M><H><T><V><F><H><R><D><K><T><K><D><T><H><P><E><S><C><C><S><S><E><K><G><G><Q><P><L><P><W><F><E><H><R><K><N><V><P><Q><F><A><E><P><T><E><T><L><F><G><P><D><S><G><K><G><A><K><S><L><V><E><L><L><D><E><S><E><C><T><S><D><E><E><I><F><I><S><Q><D><E><I><Q><S><F><M><A><N><N><Q><S><F><Y><S><N><R><E><Q><Y><R><Q><H><L><K><E><K><F><N><K><Y><C><R><L><N><D><H><K><R><P><I><C><S><G><W><L><T><T><A><G><A><N>
|
May be involved in spermatogenesis.<BOP>
|
Q9H3C7
|
P58181
|
O10A3_HUMAN
|
Olfactory receptor OR11-97
|
Homo
|
<M><K><R><Q><N><Q><S><C><V><V><E><F><I><L><L><G><F><S><N><F><P><E><L><Q><V><Q><L><F><G><V><F><L><V><I><Y><V><V><T><L><M><G><N><A><I><I><T><V><I><I><S><L><N><Q><S><L><H><V><P><M><Y><L><F><L><L><N><L><S><V><V><E><V><S><F><S><A><V><I><T><P><E><M><L><V><V><L><S><T><E><K><T><M><I><S><F><V><G><C><F><A><Q><M><Y><F><I><L><L><F><G><G><T><E><C><F><L><L><G><A><M><A><Y><D><R><F><A><A><I><C><H><P><L><N><Y><P><V><I><M><N><R><G><V><F><M><K><L><V><I><F><S><W><I><S><G><I><M><V><A><T><V><Q><T><T><W><V><F><S><F><P><F><C><G><P><N><E><I><N><H><L><F><C><E><T><P><P><V><L><E><L><V><C><A><D><T><F><L><F><E><I><Y><A><F><T><G><T><I><L><I><V><M><V><P><F><L><L><I><L><L><S><Y><I><R><V><L><F><A><I><L><K><M><P><S><T><T><G><R><Q><K><A><F><S><T><C><A><S><H><L><T><S><V><T><L><F><Y><G><T><A><N><M><T><Y><L><Q><P><K><S><G><Y><S><P><E><T><K><K><L><I><S><L><A><Y><T><L><L><T><P><L><L><N><P><L><I><Y><S><L><R><N><S><E><M><K><R><T><L><I><K><L><W><R><R><K><V><I><L><H><T><F>
|
Odorant receptor.<BOP>
|
P58181
|
P47874
|
OMP_HUMAN
|
Olfactory neuronal-specific protein
|
Homo
|
<M><A><E><D><R><P><Q><Q><P><Q><L><D><M><P><L><V><L><D><Q><G><L><T><R><Q><M><R><L><R><V><E><S><L><K><Q><R><G><E><K><R><Q><D><G><E><K><L><L><Q><P><A><E><S><V><Y><R><L><N><F><T><Q><Q><Q><R><L><Q><F><E><R><W><N><V><V><L><D><K><P><G><K><V><T><I><T><G><T><S><Q><N><W><T><P><D><L><T><N><L><M><T><R><Q><L><L><D><P><T><A><I><F><W><R><K><E><D><S><D><A><I><D><W><N><E><A><D><A><L><E><F><G><E><R><L><S><D><L><A><K><I><R><K><V><M><Y><F><L><V><T><F><G><E><G><V><E><P><A><N><L><K><A><S><V><V><F><N><Q><L>
|
May act as a modulator of the olfactory signal-transduction cascade.<BOP>
|
P47874
|
Q9H4M3
|
FBX44_HUMAN
|
F-box/G-domain protein 3
|
Homo
|
<M><A><V><G><N><I><N><E><L><P><E><N><I><L><L><E><L><F><T><H><V><P><A><R><Q><L><L><L><N><C><R><L><V><C><S><L><W><R><D><L><I><D><L><V><T><L><W><K><R><K><C><L><R><E><G><F><I><T><E><D><W><D><Q><P><V><A><D><W><K><I><F><Y><F><L><R><S><L><H><R><N><L><L><H><N><P><C><A><E><E><G><F><E><F><W><S><L><D><V><N><G><G><D><E><W><K><V><E><D><L><S><R><D><Q><R><K><E><F><P><N><D><Q><V><K><K><Y><F><V><T><S><Y><Y><T><C><L><K><S><Q><V><V><D><L><K><A><E><G><Y><W><E><E><L><M><D><T><T><R><P><D><I><E><V><K><D><W><F><A><A><R><P><D><C><G><S><K><Y><Q><L><C><V><Q><L><L><S><S><A><H><A><P><L><G><T><F><Q><P><D><P><A><T><I><Q><Q><K><S><D><A><K><W><R><E><V><S><H><T><F><S><N><Y><P><P><G><V><R><Y><I><W><F><Q><H><G><G><V><D><T><H><Y><W><A><G><W><Y><G><P><R><V><T><N><S><S><I><T><I><G><P><P><L><P>
|
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<BOP>
|
Q9H4M3
|
O43169
|
CYB5B_HUMAN
|
Cytochrome b5 outer mitochondrial membrane isoform
|
Homo
|
<M><S><G><S><M><A><T><A><E><A><S><G><S><D><G><K><G><Q><E><V><E><T><S><V><T><Y><Y><R><L><E><E><V><A><K><R><N><S><L><K><E><L><W><L><V><I><H><G><R><V><Y><D><V><T><R><F><L><N><E><H><P><G><G><E><E><V><L><L><E><Q><A><G><V><D><A><S><E><S><F><E><D><V><G><H><S><S><D><A><R><E><M><L><K><Q><Y><Y><I><G><D><I><H><P><S><D><L><K><P><E><S><G><S><K><D><P><S><K><N><D><T><C><K><S><C><W><A><Y><W><I><L><P><I><I><G><A><V><L><L><G><F><L><Y><R><Y><Y><T><S><E><S><K><S><S>
|
Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.<BOP>
|
O43169
|
A0A075B706
|
TRDJ1_HUMAN
|
T cell receptor delta joining 1
|
Homo
|
<T><D><K><L><I><F><G><K><G><T><R><V><T><V><E><P>
|
J region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition . Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair . Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells . Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential
|
A0A075B706
|
Q93062
|
RBPMS_HUMAN
|
Heart and RRM expressed sequence
|
Homo
|
<M><N><N><G><G><K><A><E><K><E><N><T><P><S><E><A><N><L><Q><E><E><E><V><R><T><L><F><V><S><G><L><P><L><D><I><K><P><R><E><L><Y><L><L><F><R><P><F><K><G><Y><E><G><S><L><I><K><L><T><S><K><Q><P><V><G><F><V><S><F><D><S><R><S><E><A><E><A><A><K><N><A><L><N><G><I><R><F><D><P><E><I><P><Q><T><L><R><L><E><F><A><K><A><N><T><K><M><A><K><N><K><L><V><G><T><P><N><P><S><T><P><L><P><N><T><V><P><Q><F><I><A><R><E><P><Y><E><L><T><V><P><A><L><Y><P><S><S><P><E><V><W><A><P><Y><P><L><Y><P><A><E><L><A><P><A><L><P><P><P><A><F><T><Y><P><A><S><L><H><A><Q><M><R><W><L><P><P><S><E><A><T><S><Q><G><W><K><S><R><Q><F><C>
|
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins . Binds to poly(A) RNA .<BOP>
|
Q93062
|
Q9UKJ1
|
PILRA_HUMAN
|
Inhibitory receptor PILR-alpha
|
Homo
|
<M><G><R><P><L><L><L><P><L><L><P><L><L><L><P><P><A><F><L><Q><P><S><G><S><T><G><S><G><P><S><Y><L><Y><G><V><T><Q><P><K><H><L><S><A><S><M><G><G><S><V><E><I><P><F><S><F><Y><Y><P><W><E><L><A><T><A><P><D><V><R><I><S><W><R><R><G><H><F><H><R><Q><S><F><Y><S><T><R><P><P><S><I><H><K><D><Y><V><N><R><L><F><L><N><W><T><E><G><Q><K><S><G><F><L><R><I><S><N><L><Q><K><Q><D><Q><S><V><Y><F><C><R><V><E><L><D><T><R><S><S><G><R><Q><Q><W><Q><S><I><E><G><T><K><L><S><I><T><Q><A><V><T><T><T><T><Q><R><P><S><S><M><T><T><T><W><R><L><S><S><T><T><T><T><T><G><L><R><V><T><Q><G><K><R><R><S><D><S><W><H><I><S><L><E><T><A><V><G><V><A><V><A><V><T><V><L><G><I><M><I><L><G><L><I><C><L><L><R><W><R><R><R><K><G><Q><Q><R><T><K><A><T><T><P><A><R><E><P><F><Q><N><T><E><E><P><Y><E><N><I><R><N><E><G><Q><N><T><D><P><K><L><N><P><K><D><D><G><I><V><Y><A><S><L><A><L><S><S><S><T><S><P><R><A><P><P><S><H><R><P><L><K><S><P><Q><N><E><T><L><Y><S><V><L><K><A>
|
(Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1.<BOP>
|
Q9UKJ1
|
Q93015
|
NAA80_HUMAN
|
Protein fusion-2
|
Homo
|
<M><E><L><I><L><S><T><S><P><A><E><L><T><L><D><P><A><C><Q><P><K><L><P><L><D><S><T><C><Q><P><E><M><T><F><N><P><G><P><T><E><L><T><L><D><P><E><H><Q><P><E><E><T><P><A><P><S><L><A><E><L><T><L><E><P><V><H><R><R><P><E><L><L><D><A><C><A><D><L><I><N><D><Q><W><P><R><S><R><T><S><R><L><H><S><L><G><Q><S><S><D><A><F><P><L><C><L><M><L><L><S><P><H><P><T><L><E><A><A><P><V><V><V><G><H><A><R><L><S><R><V><L><N><Q><P><Q><S><L><L><V><E><T><V><V><V><A><R><A><L><R><G><R><G><F><G><R><R><L><M><E><G><L><E><V><F><A><R><A><R><G><F><R><K><L><H><L><T><T><H><D><Q><V><H><F><Y><T><H><L><G><Y><Q><L><G><E><P><V><Q><G><L><V><F><T><S><R><R><L><P><A><T><L><L><N><A><F><P><T><A><P><S><P><R><P><P><R><K><A><P><N><L><T><A><Q><A><A><P><R><G><P><K><G><P><P><L><P><P><P><P><P><L><P><E><C><L><T><I><S><P><P><V><P><S><G><P><P><S><K><S><L><L><E><T><Q><Y><Q><N><V><R><G><R><P><I><F><W><M><E><K><D><I>
|
N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) . N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation . In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu . In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp . May act as a tumor suppressor .<BOP>
|
Q93015
|
P61073
|
CXCR4_HUMAN
|
Stromal cell-derived factor 1 receptor
|
Homo
|
<M><E><G><I><S><I><Y><T><S><D><N><Y><T><E><E><M><G><S><G><D><Y><D><S><M><K><E><P><C><F><R><E><E><N><A><N><F><N><K><I><F><L><P><T><I><Y><S><I><I><F><L><T><G><I><V><G><N><G><L><V><I><L><V><M><G><Y><Q><K><K><L><R><S><M><T><D><K><Y><R><L><H><L><S><V><A><D><L><L><F><V><I><T><L><P><F><W><A><V><D><A><V><A><N><W><Y><F><G><N><F><L><C><K><A><V><H><V><I><Y><T><V><N><L><Y><S><S><V><L><I><L><A><F><I><S><L><D><R><Y><L><A><I><V><H><A><T><N><S><Q><R><P><R><K><L><L><A><E><K><V><V><Y><V><G><V><W><I><P><A><L><L><L><T><I><P><D><F><I><F><A><N><V><S><E><A><D><D><R><Y><I><C><D><R><F><Y><P><N><D><L><W><V><V><V><F><Q><F><Q><H><I><M><V><G><L><I><L><P><G><I><V><I><L><S><C><Y><C><I><I><I><S><K><L><S><H><S><K><G><H><Q><K><R><K><A><L><K><T><T><V><I><L><I><L><A><F><F><A><C><W><L><P><Y><Y><I><G><I><S><I><D><S><F><I><L><L><E><I><I><K><Q><G><C><E><F><E><N><T><V><H><K><W><I><S><I><T><E><A><L><A><F><F><H><C><C><L><N><P><I><L><Y><A><F><L><G><A><K><F><K><T><S><A><Q><H><A><L><T><S><V><S><R><G><S><S><L><K><I><L><S><K><G><K><R><G><G><H><S><S><V><S><T><E><S><E><S><S><S><F><H><S><S>
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(Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus .<BOP>
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P61073
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Q9H902
|
REEP1_HUMAN
|
Spastic paraplegia 31 protein
|
Homo
|
<M><V><S><W><I><I><S><R><L><V><V><L><I><F><G><T><L><Y><P><A><Y><Y><S><Y><K><A><V><K><S><K><D><I><K><E><Y><V><K><W><M><M><Y><W><I><I><F><A><L><F><T><T><A><E><T><F><T><D><I><F><L><C><W><F><P><F><Y><Y><E><L><K><I><A><F><V><A><W><L><L><S><P><Y><T><K><G><S><S><L><L><Y><R><K><F><V><H><P><T><L><S><S><K><E><K><E><I><D><D><C><L><V><Q><A><K><D><R><S><Y><D><A><L><V><H><F><G><K><R><G><L><N><V><A><A><T><A><A><V><M><A><A><S><K><G><Q><G><A><L><S><E><R><L><R><S><F><S><M><Q><D><L><T><T><I><R><G><D><G><A><P><A><P><S><G><P><P><P><P><G><S><G><R><A><S><G><K><H><G><Q><P><K><M><S><R><S><A><S><E><S><A><S><S><S><G><T><A>
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Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors . May play a role in long-term axonal maintenance .<BOP>
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Q9H902
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Q6UWI4
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SHSA2_HUMAN
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Transmembrane protein 46
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Homo
|
<M><W><G><A><R><R><S><S><V><S><S><S><W><N><A><A><S><L><L><Q><L><L><L><A><A><L><L><A><A><G><A><R><A><S><G><E><Y><C><H><G><W><L><D><A><Q><G><V><W><R><I><G><F><Q><C><P><E><R><F><D><G><G><D><A><T><I><C><C><G><S><C><A><L><R><Y><C><C><S><S><A><E><A><R><L><D><Q><G><G><C><D><N><D><R><Q><Q><G><A><G><E><P><G><R><A><D><K><D><G><P><D><G><S><A><V><P><I><Y><V><P><F><L><I><V><G><S><V><F><V><A><F><I><I><L><G><S><L><V><A><A><C><C><C><R><C><L><R><P><K><Q><D><P><Q><Q><S><R><A><P><G><G><N><R><L><M><E><T><I><P><M><I><P><S><A><S><T><S><R><G><S><S><S><R><Q><S><S><T><A><A><S><S><S><S><S><A><N><S><G><A><R><A><P><P><T><R><S><Q><T><N><C><C><L><P><E><G><T><M><N><N><V><Y><V><N><M><P><T><N><F><S><V><L><N><C><Q><Q><A><T><Q><I><V><P><H><Q><G><Q><Y><L><H><P><P><Y><V><G><Y><T><V><Q><H><D><S><V><P><M><T><A><V><P><P><F><M><D><G><L><Q><P><G><Y><R><Q><I><Q><S><P><F><P><H><T><N><S><E><Q><K><M><Y><P><A><V><T><V>
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Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.<BOP>
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Q6UWI4
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Q8TEB9
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RHBL4_HUMAN
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Rhomboid-like protein 4
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Homo
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<M><Q><R><R><S><R><G><I><N><T><G><L><I><L><L><L><S><Q><I><F><H><V><G><I><N><N><I><P><P><V><T><L><A><T><L><A><L><N><I><W><F><F><L><N><P><Q><K><P><L><Y><S><S><C><L><S><V><E><K><C><Y><Q><Q><K><D><W><Q><R><L><L><L><S><P><L><H><H><A><D><D><W><H><L><Y><F><N><M><A><S><M><L><W><K><G><I><N><L><E><R><R><L><G><S><R><W><F><A><Y><V><I><T><A><F><S><V><L><T><G><V><V><Y><L><L><L><Q><F><A><V><A><E><F><M><D><E><P><D><F><K><R><S><C><A><V><G><F><S><G><V><L><F><A><L><K><V><L><N><N><H><Y><C><P><G><G><F><V><N><I><L><G><F><P><V><P><N><R><F><A><C><W><V><E><L><V><A><I><H><L><F><S><P><G><T><S><F><A><G><H><L><A><G><I><L><V><G><L><M><Y><T><Q><G><P><L><K><K><I><M><E><A><C><A><G><G><F><S><S><S><V><G><Y><P><G><R><Q><Y><Y><F><N><S><S><G><S><S><G><Y><Q><D><Y><Y><P><H><G><R><P><D><H><Y><E><E><A><P><R><N><Y><D><T><Y><T><A><G><L><S><E><E><E><Q><L><E><R><A><L><Q><A><S><L><W><D><R><G><N><T><R><N><S><P><P><P><Y><G><F><H><L><S><P><E><E><M><R><R><Q><R><L><H><R><F><D><S><Q>
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Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia.<BOP>
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Q8TEB9
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Q9NWZ8
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GEMI8_HUMAN
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Protein FAM51A1
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Homo
|
<M><A><A><V><K><A><S><T><S><K><A><T><R><P><W><Y><S><H><P><V><Y><A><R><Y><W><Q><H><Y><H><Q><A><M><A><W><M><Q><S><H><H><N><A><Y><R><K><A><V><E><S><C><F><N><L><P><W><Y><L><P><S><A><L><L><P><Q><S><S><Y><D><N><E><A><A><Y><P><Q><S><F><Y><D><H><H><V><A><W><Q><D><Y><P><C><S><S><S><H><F><R><R><S><G><Q><H><P><R><Y><S><S><R><I><Q><A><S><T><K><E><D><Q><A><L><S><K><E><E><E><M><E><T><E><S><D><A><E><V><E><C><D><L><S><N><M><E><I><T><E><E><L><R><Q><Y><F><A><E><T><E><R><H><R><E><E><R><R><R><Q><Q><Q><L><D><A><E><R><L><D><S><Y><V><N><A><D><H><D><L><Y><C><N><T><R><R><S><V><E><A><P><T><E><R><P><G><E><R><R><Q><A><E><M><K><R><L><Y><G><D><S><A><A><K><I><Q><A><M><E><A><A><V><Q><L><S><F><D><K><H><C><D><R><K><Q><P><K><Y><W><P><V><I><P><L><K><F>
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The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.<BOP>
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Q9NWZ8
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Q96C00
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ZBTB9_HUMAN
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Zinc finger and BTB domain-containing protein 9
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Homo
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<M><E><T><P><T><P><L><P><P><V><P><A><S><P><T><C><N><P><A><P><R><T><I><Q><I><E><F><P><Q><H><S><S><S><L><L><E><S><L><N><R><H><R><L><E><G><K><F><C><D><V><S><L><L><V><Q><G><R><E><L><R><A><H><K><A><V><L><A><A><A><S><P><Y><F><H><D><K><L><L><L><G><D><A><P><R><L><T><L><P><S><V><I><E><A><D><A><F><E><G><L><L><Q><L><I><Y><S><G><R><L><R><L><P><L><D><A><L><P><A><H><L><L><V><A><S><G><L><Q><M><W><Q><V><V><D><Q><C><S><E><I><L><R><E><L><E><T><S><G><G><G><I><S><A><R><G><G><N><S><Y><H><A><L><L><S><T><T><S><S><T><G><G><W><C><I><R><S><S><P><F><Q><T><P><V><Q><S><S><A><S><T><E><S><P><A><S><T><E><S><P><V><G><G><E><G><S><E><L><G><E><V><L><Q><I><Q><V><E><E><E><E><E><E><E><E><D><D><D><D><E><D><Q><G><S><A><T><L><S><Q><T><P><Q><P><Q><R><V><S><G><V><F><P><R><P><H><G><P><H><P><L><P><M><T><A><T><P><R><K><L><P><E><G><E><S><A><P><L><E><L><P><A><P><P><A><L><P><P><K><I><F><Y><I><K><Q><E><P><F><E><P><K><E><E><I><S><G><S><G><T><Q><P><G><G><A><K><E><E><T><K><V><F><S><G><G><D><T><E><G><N><G><E><L><G><F><L><L><P><S><G><P><G><P><T><S><G><G><G><G><P><S><W><K><P><V><D><L><H><G><N><E><I><L><S><G><G><G><G><P><G><G><A><G><Q><A><V><H><G><P><V><K><L><G><G><T><P><P><A><D><G><K><R><F><G><C><L><C><G><K><R><F><A><V><K><P><K><R><D><R><H><I><M><L><T><F><S><L><R><P><F><G><C><G><I><C><N><K><R><F><K><L><K><H><H><L><T><E><H><M><K><T><H><A><G><A><L><H><A><C><P><H><C><G><R><R><F><R><V><H><A><C><F><L><R><H><R><D><L><C><K><G><Q><G><W><A><T><A><H><W><T><Y><K>
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May be involved in transcriptional regulation.<BOP>
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Q96C00
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O76100
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OR7AA_HUMAN
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Olfactory receptor OR19-18
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Homo
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<M><K><S><W><N><N><T><I><I><L><E><F><L><L><L><G><I><S><E><E><P><E><L><Q><A><F><L><F><G><L><F><L><S><M><Y><L><V><T><V><L><G><N><L><L><I><I><L><A><T><I><S><D><S><H><L><H><T><P><M><Y><F><F><L><S><N><L><S><F><V><D><I><C><F><V><S><T><T><V><P><K><M><L><V><N><I><Q><T><H><N><K><V><I><T><Y><A><G><C><I><T><Q><M><C><F><F><L><L><F><V><G><L><D><N><F><L><L><T><V><M><A><Y><D><R><F><V><A><I><C><H><P><L><H><Y><M><V><I><M><N><P><Q><L><C><G><L><L><V><L><A><S><W><I><M><S><V><L><N><S><M><L><Q><S><L><M><V><L><P><L><P><F><C><T><H><M><E><I><P><H><F><F><C><E><I><N><Q><V><V><H><L><A><C><S><D><T><F><L><N><D><I><V><M><Y><F><A><V><A><L><L><G><G><G><P><L><T><G><I><L><Y><S><Y><S><K><I><V><S><S><I><R><A><I><S><S><A><Q><G><K><Y><K><A><F><S><T><C><A><S><H><L><S><V><V><S><L><F><Y><G><T><C><L><G><V><Y><L><S><S><A><A><T><H><N><S><H><T><G><A><A><A><S><V><M><Y><T><V><V><T><P><M><L><N><P><F><I><Y><S><L><R><N><K><H><I><K><G><A><M><K><T><F><F><R><G><K><Q>
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Odorant receptor.<BOP>
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O76100
|
O43678
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NDUA2_HUMAN
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NADH-ubiquinone oxidoreductase B8 subunit
|
Homo
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<M><A><A><A><A><A><S><R><G><V><G><A><K><L><G><L><R><E><I><R><I><H><L><C><Q><R><S><P><G><S><Q><G><V><R><D><F><I><E><K><R><Y><V><E><L><K><K><A><N><P><D><L><P><I><L><I><R><E><C><S><D><V><Q><P><K><L><W><A><R><Y><A><F><G><Q><E><T><N><V><P><L><N><N><F><S><A><D><Q><V><T><R><A><L><E><N><V><L><S><G><K><A>
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Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.<BOP>
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O43678
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Q9H310
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RHBG_HUMAN
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Rhesus blood group family type B glycoprotein
|
Homo
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<M><A><G><S><P><S><R><A><A><G><R><R><L><Q><L><P><L><L><C><L><F><L><Q><G><A><T><A><V><L><F><A><V><F><V><R><Y><N><H><K><T><D><A><A><L><W><H><R><S><N><H><S><N><A><D><N><E><F><Y><F><R><Y><P><S><F><Q><D><V><H><A><M><V><F><V><G><F><G><F><L><M><V><F><L><Q><R><Y><G><F><S><S><V><G><F><T><F><L><L><A><A><F><A><L><Q><W><S><T><L><V><Q><G><F><L><H><S><F><H><G><G><H><I><H><V><G><V><E><S><M><I><N><A><D><F><C><A><G><A><V><L><I><S><F><G><A><V><L><G><K><T><G><P><T><Q><L><L><L><M><A><L><L><E><V><V><L><F><G><I><N><E><F><V><L><L><H><L><L><G><V><R><D><A><G><G><S><M><T><I><H><T><F><G><A><Y><F><G><L><V><L><S><R><V><L><Y><R><P><Q><L><E><K><S><K><H><R><Q><G><S><V><Y><H><S><D><L><F><A><M><I><G><T><I><F><L><W><I><F><W><P><S><F><N><A><A><L><T><A><L><G><A><G><Q><H><R><T><A><L><N><T><Y><Y><S><L><A><A><S><T><L><G><T><F><A><L><S><A><L><V><G><E><D><G><R><L><D><M><V><H><I><Q><N><A><A><L><A><G><G><V><V><V><G><T><S><S><E><M><M><L><T><P><F><G><A><L><A><A><G><F><L><A><G><T><V><S><T><L><G><Y><K><F><F><T><P><I><L><E><S><K><F><K><V><Q><D><T><C><G><V><H><N><L><H><G><M><P><G><V><L><G><A><L><L><G><V><L><V><A><G><L><A><T><H><E><A><Y><G><D><G><L><E><S><V><F><P><L><I><A><E><G><Q><R><S><A><T><S><Q><A><M><H><Q><L><F><G><L><F><V><T><L><M><F><A><S><V><G><G><G><L><G><G><L><L><L><K><L><P><F><L><D><S><P><P><D><S><Q><H><Y><E><D><Q><V><H><W><Q><V><P><G><E><H><E><D><K><A><Q><R><P><L><R><V><E><E><A><D><T><Q><A>
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Functions as a specific ammonium transporter.<BOP>
|
Q9H310
|
P57723
|
PCBP4_HUMAN
|
Alpha-CP4
|
Homo
|
<M><S><G><S><D><G><G><L><E><E><E><P><E><L><S><I><T><L><T><L><R><M><L><M><H><G><K><E><V><G><S><I><I><G><K><K><G><E><T><V><K><R><I><R><E><Q><S><S><A><R><I><T><I><S><E><G><S><C><P><E><R><I><T><T><I><T><G><S><T><A><A><V><F><H><A><V><S><M><I><A><F><K><L><D><E><D><L><C><A><A><P><A><N><G><G><N><V><S><R><P><P><V><T><L><R><L><V><I><P><A><S><Q><C><G><S><L><I><G><K><A><G><T><K><I><K><E><I><R><E><T><T><G><A><Q><V><Q><V><A><G><D><L><L><P><N><S><T><E><R><A><V><T><V><S><G><V><P><D><A><I><I><L><C><V><R><Q><I><C><A><V><I><L><E><S><P><P><K><G><A><T><I><P><Y><H><P><S><L><S><L><G><T><V><L><L><S><A><N><Q><G><F><S><V><Q><G><Q><Y><G><A><V><T><P><A><E><V><T><K><L><Q><Q><L><S><S><H><A><V><P><F><A><T><P><S><V><V><P><G><L><D><P><G><T><Q><T><S><S><Q><E><F><L><V><P><N><D><L><I><G><C><V><I><G><R><Q><G><S><K><I><S><E><I><R><Q><M><S><G><A><H><I><K><I><G><N><Q><A><E><G><A><G><E><R><H><V><T><I><T><G><S><P><V><S><I><A><L><A><Q><Y><L><I><T><A><C><L><E><T><A><K><S><T><S><G><G><T><P><S><S><A><P><A><D><L><P><A><P><F><S><P><P><L><T><A><L><P><T><A><P><P><G><L><L><G><T><P><Y><A><I><S><L><S><N><F><I><G><L><K><P><M><P><F><L><A><L><P><P><A><S><P><G><P><P><P><G><L><A><A><Y><T><A><K><M><A><A><A><N><G><S><K><K><A><E><R><Q><K><F><S><P><Y>
|
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.<BOP>
|
P57723
|
P51815
|
ZN75D_HUMAN
|
Zinc finger protein 82
|
Homo
|
<M><A><M><R><E><L><N><A><D><S><C><S><S><P><Q><M><G><A><M><W><E><T><S><G><S><V><K><E><N><S><S><Q><S><K><K><Y><S><T><K><I><E><N><L><G><P><E><S><A><C><R><H><F><W><S><F><R><Y><H><E><A><T><G><P><L><E><T><I><S><Q><L><Q><K><L><C><H><Q><W><L><R><P><E><I><H><S><K><E><Q><I><L><E><M><L><V><L><E><Q><F><L><S><I><L><P><K><E><T><Q><N><W><V><Q><K><H><H><P><Q><N><V><K><Q><A><L><V><L><V><E><F><L><Q><R><E><P><D><G><T><K><N><E><V><T><A><H><E><L><G><K><E><A><V><L><L><G><G><T><A><V><A><P><G><F><K><W><K><P><A><E><P><Q><P><M><G><V><F><Q><K><E><Y><W><N><T><Y><R><V><L><Q><E><Q><L><G><W><N><T><H><K><E><T><Q><P><V><Y><E><R><A><V><H><D><Q><Q><M><L><A><L><S><E><Q><K><R><I><K><H><W><K><M><A><S><K><L><I><L><P><E><S><L><S><L><L><T><F><E><D><V><A><V><Y><F><S><E><E><E><W><Q><L><L><N><P><L><E><K><T><L><Y><N><D><V><M><Q><D><I><Y><E><T><V><I><S><L><G><L><K><L><K><N><D><T><G><N><D><H><P><I><S><V><S><T><S><E><I><Q><T><S><G><C><E><V><S><K><K><T><R><M><K><I><A><Q><K><T><M><G><R><E><N><P><G><D><T><H><S><V><Q><K><W><H><R><A><F><P><R><K><K><R><K><K><P><A><T><C><K><Q><E><L><P><K><L><M><D><L><H><G><K><G><P><T><G><E><K><P><F><K><C><Q><E><C><G><K><S><F><R><V><S><S><D><L><I><K><H><H><R><I><H><T><G><E><K><P><Y><K><C><Q><Q><C><D><R><R><F><R><W><S><S><D><L><N><K><H><F><M><T><H><Q><G><I><K><P><Y><R><C><S><W><C><G><K><S><F><S><H><N><T><N><L><H><T><H><Q><R><I><H><T><G><E><K><P><F><K><C><D><E><C><G><K><R><F><I><Q><N><S><H><L><I><K><H><Q><R><T><H><T><G><E><Q><P><Y><T><C><S><L><C><K><R><N><F><S><R><R><S><S><L><L><R><H><Q><K><L><H><R><R><R><E><A><C><L><V><S><P><N>
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May be involved in transcriptional regulation.<BOP>
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P51815
|
O43242
|
PSMD3_HUMAN
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Proteasome subunit p58
|
Homo
|
<M><K><Q><E><G><S><A><R><R><R><G><A><D><K><A><K><P><P><P><G><G><G><E><Q><E><P><P><P><P><P><A><P><Q><D><V><E><M><K><E><E><A><A><T><G><G><G><S><T><G><E><A><D><G><K><T><A><A><A><A><A><E><H><S><Q><R><E><L><D><T><V><T><L><E><D><I><K><E><H><V><K><Q><L><E><K><A><V><S><G><K><E><P><R><F><V><L><R><A><L><R><M><L><P><S><T><S><R><R><L><N><H><Y><V><L><Y><K><A><V><Q><G><F><F><T><S><N><N><A><T><R><D><F><L><L><P><F><L><E><E><P><M><D><T><E><A><D><L><Q><F><R><P><R><T><G><K><A><A><S><T><P><L><L><P><E><V><E><A><Y><L><Q><L><L><V><V><I><F><M><M><N><S><K><R><Y><K><E><A><Q><K><I><S><D><D><L><M><Q><K><I><S><T><Q><N><R><R><A><L><D><L><V><A><A><K><C><Y><Y><Y><H><A><R><V><Y><E><F><L><D><K><L><D><V><V><R><S><F><L><H><A><R><L><R><T><A><T><L><R><H><D><A><D><G><Q><A><T><L><L><N><L><L><L><R><N><Y><L><H><Y><S><L><Y><D><Q><A><E><K><L><V><S><K><S><V><F><P><E><Q><A><N><N><N><E><W><A><R><Y><L><Y><Y><T><G><R><I><K><A><I><Q><L><E><Y><S><E><A><R><R><T><M><T><N><A><L><R><K><A><P><Q><H><T><A><V><G><F><K><Q><T><V><H><K><L><L><I><V><V><E><L><L><L><G><E><I><P><D><R><L><Q><F><R><Q><P><S><L><K><R><S><L><M><P><Y><F><L><L><T><Q><A><V><R><T><G><N><L><A><K><F><N><Q><V><L><D><Q><F><G><E><K><F><Q><A><D><G><T><Y><T><L><I><I><R><L><R><H><N><V><I><K><T><G><V><R><M><I><S><L><S><Y><S><R><I><S><L><A><D><I><A><Q><K><L><Q><L><D><S><P><E><D><A><E><F><I><V><A><K><A><I><R><D><G><V><I><E><A><S><I><N><H><E><K><G><Y><V><Q><S><K><E><M><I><D><I><Y><S><T><R><E><P><Q><L><A><F><H><Q><R><I><S><F><C><L><D><I><H><N><M><S><V><K><A><M><R><F><P><P><K><S><Y><N><K><D><L><E><S><A><E><E><R><R><E><R><E><Q><Q><D><L><E><F><A><K><E><M><A><E><D><D><D><D><S><F><P>
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Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.<BOP>
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O43242
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A6NDX5
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ZN840_HUMAN
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Zinc finger protein 840 pseudogene
|
Homo
|
<M><S><L><M><G><H><G><K><V><E><M><L><L><Y><A><V><P><L><L><K><A><P><N><C><L><S><S><S><M><Q><L><P><H><G><G><G><R><H><Q><E><L><V><R><F><R><D><V><A><V><V><F><S><P><E><E><W><D><H><L><T><P><E><Q><R><N><L><Y><K><D><V><M><L><D><N><C><K><Y><L><A><S><L><G><N><W><T><Y><K><A><H><V><M><S><S><L><K><Q><G><K><E><P><W><M><M><E><R><E><V><T><G><D><P><C><P><A><C><Q><P><A><L><A><T><F><R><A><L><N><E><S><G><N><A><F><R><Q><S><F><H><H><G><E><Y><R><T><H><R><T><F><V><Q><H><Y><E><C><D><D><C><G><M><A><F><G><H><V><S><Q><L><T><G><H><Q><K><I><H><K><V><G><E><T><H><E><Y><G><E><N><T><R><G><F><R><H><R><S><S><F><T><M><L><Q><R><I><C><T><L><Y><K><H><F><E><C><N><Q><C><G><E><T><F><N><R><P><S><K><V><I><Q><H><Q><S><M><H><S><G><L><K><P><Y><K><C><D><V><C><Q><K><A><F><R><F><L><S><S><L><S><I><H><Q><R><F><H><V><G><N><R><V><N><L><T><R><H><Q><K><T><H><T><Q><R><K><P><F><S><C><N><F><C><G><K><T><F><H><R><F><S><E><K><T><Q><H><L><L><I><H><T><R><K><K><Y><Y><T><C><N><Y><C><K><K><E><F><N><P><Y><S><K><F><I><L><H><Q><R><T><H><T><G><E><K><P><H><K><C><D><V><C><E><K><S><F><K><S><I><S><N><L><N><K><H><Q><K><T><H><T><G><E><K><P><F><S><C><N><E><C><K><K><T><F><A><Q><R><T><D><L><A><R><H><Q><Q><I><H><T><G><K><K><S><F><I><C><S><S><C><K><K><T><F><V><R><L><S><D><L><T><Q><H><K><G><T><H><T><G><E><R><P><Y><Q><C><T><T><C><E><K><A><F><K><Y><R><S><N><F><T><K><H><Q><K><T><H><S><I><G><R><P><F><A><C><N><E><C><G><K><T><Y><R><L><N><W><E><L><N><Q><H><K><K><I><H><T><G><E><K><P><Y><E><C><G><E><C><G><K><R><F><N><N><N><S><N><L><N><K><H><K><K><I><H><T><G><E><K><H><F><V><C><N><Q><C><G><K><A><F><S><L><N><S><K><L><S><R><H><Q><R><T><H><N><K><K><E><N><S><S><K><S><V><S><N><L><N><K><H><Q><K><T><H><A><G><E><K><P><F><P><C><N><E><C><K><K><A><F><A><Q><R><M><D><L><A><R><H><Q><Q><I><H><T><G><R><K><P><F><I><C><S><S><C><K><K><T><F><V><R><L><S><D><L><T><Q><H><K><G><T><H><T><G><E><R><P><Y><Q><C><T><T><C><E><K><A><F><K><Y><Q><S><N><F><T><K><H><Q><K><T><H><S><I><G><R><P><F><T><C><N><E><C><G><K><T><F><R><L><N><W><K><L><N><Q><H><K><K><I><H><T><G><E><K><P><Y><E><C><G><E><C><G><K><C><F><N><N><N><S><N><L><S><K><H><K><K><I><H><T><G><E><K><H><F><V><C><N><Q><C><G><K><A><F><S><L><N><S><K><L><S><R><H><Q><I><T><H><N><K><K><K><P>
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May be involved in transcriptional regulation.<BOP>
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A6NDX5
|
Q5VVY1
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NTM1B_HUMAN
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X-Pro-Lys N-terminal protein methyltransferase 1B
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Homo
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<M><A><H><R><G><A><H><F><A><F><R><S><R><W><Q><K><T><D><D><E><L><C><R><H><S><M><S><F><I><L><H><K><A><I><R><N><D><F><F><Q><S><Y><L><Y><L><L><E><K><I><P><L><V><K><L><Y><A><L><T><S><Q><V><I><N><G><E><M><Q><F><Y><A><R><A><K><L><F><Y><Q><E><V><P><A><T><E><E><G><M><M><G><N><F><I><E><L><S><S><P><D><I><Q><A><S><Q><K><F><L><R><K><F><V><G><G><P><G><R><A><G><T><D><C><A><L><D><C><G><S><G><I><G><R><V><S><K><H><V><L><L><P><V><F><N><S><V><E><L><V><D><M><M><E><S><F><L><L><E><A><Q><N><Y><L><Q><V><K><G><D><K><V><E><S><Y><H><C><Y><S><L><Q><E><F><T><P><P><F><R><R><Y><D><V><I><W><I><Q><W><V><S><G><H><L><T><D><K><D><L><L><A><F><L><S><R><C><R><D><G><L><K><E><N><G><I><I><I><L><K><D><N><V><A><R><E><G><C><I><L><D><L><S><D><S><S><V><T><R><D><M><D><I><L><R><S><L><I><R><K><S><G><L><V><V><L><G><Q><E><K><Q><D><G><F><P><E><Q><C><I><P><V><W><M><F><A><L><H><S><D><R><H><S>
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Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif . Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro) . May activate NTMT1 by priming its substrates for trimethylation .<BOP>
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Q5VVY1
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Q8NGF0
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O52B6_HUMAN
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Olfactory receptor OR11-47
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Homo
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<M><A><Q><V><R><A><L><H><K><I><M><A><L><F><S><A><N><S><I><G><A><M><N><N><S><D><T><R><I><A><G><C><F><L><T><G><I><P><G><L><E><Q><L><H><I><W><L><S><I><P><F><C><I><M><Y><I><T><A><L><E><G><N><G><I><L><I><C><V><I><L><S><Q><A><I><L><H><E><P><M><Y><I><F><L><S><M><L><A><S><A><D><V><L><L><S><T><T><T><M><P><K><A><L><A><N><L><W><L><G><Y><S><L><I><S><F><D><G><C><L><T><Q><M><F><F><I><H><F><L><F><I><H><S><A><V><L><L><A><M><A><F><D><R><Y><V><A><I><C><S><P><L><R><Y><V><T><I><L><T><S><K><V><I><G><K><I><V><T><A><A><L><S><H><S><F><I><I><M><F><P><S><I><F><L><L><E><H><L><H><Y><C><Q><I><N><I><I><A><H><T><F><C><E><H><M><G><I><A><H><L><S><C><S><D><I><S><I><N><V><W><Y><G><L><A><A><A><L><L><S><T><G><L><D><I><M><L><I><T><V><S><Y><I><H><I><L><Q><A><V><F><R><L><L><S><Q><D><A><R><S><K><A><L><S><T><C><G><S><H><I><C><V><I><L><L><F><Y><V><P><A><L><F><S><V><F><A><Y><R><F><G><G><R><S><V><P><C><Y><V><H><I><L><L><A><S><L><Y><V><V><I><P><P><M><L><N><P><V><I><Y><G><V><R><T><K><P><I><L><E><G><A><K><Q><M><F><S><N><L><A><K><G><S><K>
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Odorant receptor.<BOP>
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Q8NGF0
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Q9Y6A4
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CFA20_HUMAN
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Transcription factor IIB
|
Homo
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<M><F><K><N><T><F><Q><S><G><F><L><S><I><L><Y><S><I><G><S><K><P><L><Q><I><W><D><K><K><V><R><N><G><H><I><K><R><I><T><D><N><D><I><Q><S><L><V><L><E><I><E><G><T><N><V><S><T><T><Y><I><T><C><P><A><D><P><K><K><T><L><G><I><K><L><P><F><L><V><M><I><I><K><N><L><K><K><Y><F><T><F><E><V><Q><V><L><D><D><K><N><V><R><R><R><F><R><A><S><N><Y><Q><S><T><T><R><V><K><P><F><I><C><T><M><P><M><R><L><D><D><G><W><N><Q><I><Q><F><N><L><L><D><F><T><R><R><A><Y><G><T><N><Y><I><E><T><L><R><V><Q><I><H><A><N><C><R><I><R><R><V><Y><F><S><D><R><L><Y><S><E><D><E><L><P><A><E><F><K><L><Y><L><P><V><Q><N><K><A><K><Q>
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Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia . Required for axonemal microtubules polyglutamylation .<BOP>
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Q9Y6A4
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Q8NGG8
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OR8B3_HUMAN
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Olfactory receptor OR11-311
|
Homo
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<M><L><A><R><N><N><S><L><V><T><E><F><I><L><A><G><L><T><D><H><P><E><F><Q><Q><P><L><F><F><L><F><L><V><V><Y><I><V><T><M><V><G><N><L><G><L><I><I><L><F><G><L><N><S><H><L><H><T><P><M><Y><Y><F><L><F><N><L><S><F><I><D><L><C><Y><S><S><V><F><T><P><K><M><L><M><N><F><V><S><K><K><N><I><I><S><Y><V><G><C><M><T><Q><L><F><F><F><L><F><F><V><I><S><E><C><Y><M><L><T><S><M><A><Y><D><R><Y><V><A><I><C><N><P><L><L><Y><K><V><T><M><S><H><Q><V><C><S><M><L><T><F><A><A><Y><I><M><G><L><A><G><A><T><A><H><T><G><C><M><L><R><L><T><F><C><S><A><N><I><I><N><H><Y><L><C><D><I><L><P><L><L><Q><L><S><C><T><S><T><Y><V><N><E><V><V><V><L><I><V><V><G><I><N><I><M><V><P><S><C><T><I><L><I><S><Y><V><F><I><V><T><S><I><L><H><I><K><S><T><Q><G><R><S><K><A><F><S><T><C><S><S><H><V><I><A><L><S><L><F><F><G><S><A><A><F><M><Y><I><K><Y><S><S><G><S><M><E><Q><G><K><V><S><S><V><F><Y><T><N><V><V><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><K><V><A><L><R><K><A><L><I><K><I><Q><R><R><N><I><F>
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Odorant receptor.<BOP>
|
Q8NGG8
|
Q96PH6
|
DB118_HUMAN
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Epididymal secretory protein 13.6
|
Homo
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<M><K><L><L><L><L><A><L><P><M><L><V><L><L><P><Q><V><I><P><A><Y><S><G><E><K><K><C><W><N><R><S><G><H><C><R><K><Q><C><K><D><G><E><A><V><K><D><T><C><K><N><L><R><A><C><C><I><P><S><N><E><D><H><R><R><V><P><A><T><S><P><T><P><L><S><D><S><T><P><G><I><I><D><D><I><L><T><V><R><F><T><T><D><Y><F><E><V><S><S><K><K><D><M><V><E><E><S><E><A><G><R><G><T><E><T><S><L><P><N><V><H><H><S><S>
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Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E.coli and S.typhimurium, and Gram-positive bacteria, such as S.aureus and B.subtilis . Inhibits cell adhesion of E.coli on intestinal epithelial enterocytes . Causes rapid permeabilization of both the outer and inner membrane of E.coli, leading to morphological alterations on the bacterial surface . Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization . May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms .<BOP>
|
Q96PH6
|
Q9NYW4
|
TA2R5_HUMAN
|
Taste receptor type 2 member 5
|
Homo
|
<M><L><S><A><G><L><G><L><L><M><L><V><A><V><V><E><F><L><I><G><L><I><G><N><G><S><L><V><V><W><S><F><R><E><W><I><R><K><F><N><W><S><S><Y><N><L><I><I><L><G><L><A><G><C><R><F><L><L><Q><W><L><I><I><L><D><L><S><L><F><P><L><F><Q><S><S><R><W><L><R><Y><L><S><I><F><W><V><L><V><S><Q><A><S><L><W><F><A><T><F><L><S><V><F><Y><C><K><K><I><T><T><F><D><R><P><A><Y><L><W><L><K><Q><R><A><Y><N><L><S><L><W><C><L><L><G><Y><F><I><I><N><L><L><L><T><V><Q><I><G><L><T><F><Y><H><P><P><Q><G><N><S><S><I><R><Y><P><F><E><S><W><Q><Y><L><Y><A><F><Q><L><N><S><G><S><Y><L><P><L><V><V><F><L><V><S><S><G><M><L><I><V><S><L><Y><T><H><H><K><K><M><K><V><H><S><A><G><R><R><D><V><R><A><K><A><H><I><T><A><L><K><S><L><G><C><F><L><L><L><H><L><V><Y><I><M><A><S><P><F><S><I><T><S><K><T><Y><P><P><D><L><T><S><V><F><I><W><E><T><L><M><A><A><Y><P><S><L><H><S><L><I><L><I><M><G><I><P><R><V><K><Q><T><C><Q><K><I><L><W><K><T><V><C><A><R><R><C><W><G><P>
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Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.<BOP>
|
Q9NYW4
|
Q6SJ93
|
F111B_HUMAN
|
Cancer-associated nucleoprotein
|
Homo
|
<M><N><S><M><K><T><E><E><N><K><S><F><S><A><M><E><D><D><Q><R><T><R><P><E><V><S><K><D><T><V><M><K><Q><T><H><A><D><T><P><V><D><H><C><L><S><G><I><R><K><C><S><S><T><F><K><L><K><S><E><V><N><K><H><E><T><A><L><E><M><Q><N><P><N><L><N><N><K><E><C><C><F><T><F><T><L><N><G><N><S><R><K><L><D><R><S><V><F><T><A><Y><G><K><P><S><E><S><I><Y><S><A><L><S><A><N><D><Y><F><S><E><R><I><K><N><Q><F><N><K><N><I><I><V><Y><E><E><K><T><I><D><G><H><I><N><L><G><M><P><L><K><C><L><P><S><D><S><H><F><K><I><T><F><G><Q><R><K><S><S><K><E><D><G><H><I><L><R><Q><C><E><N><P><N><M><E><C><I><L><F><H><V><V><A><I><G><R><T><R><K><K><I><V><K><I><N><E><L><H><E><K><G><S><K><L><C><I><Y><A><L><K><G><E><T><I><E><G><A><L><C><K><D><G><R><F><R><S><D><I><G><E><F><E><W><K><L><K><E><G><H><K><K><I><Y><G><K><Q><S><M><V><D><E><V><S><G><K><V><L><E><M><D><I><S><K><K><K><A><L><Q><Q><K><D><I><H><K><K><I><K><Q><N><E><S><A><T><D><E><I><N><H><Q><S><L><I><Q><S><K><K><K><V><H><K><P><K><K><D><G><E><T><K><D><V><E><H><S><R><E><Q><I><L><P><P><Q><D><L><S><H><Y><I><K><D><K><T><R><Q><T><I><P><R><I><R><N><Y><Y><F><C><S><L><P><R><K><Y><R><Q><I><N><S><Q><V><R><R><R><P><H><L><G><R><R><Y><A><I><N><L><D><V><Q><K><E><A><I><N><L><L><K><N><Y><Q><T><L><N><E><A><I><M><H><Q><Y><P><N><F><K><E><E><A><Q><W><V><R><K><Y><F><R><E><E><Q><K><R><M><N><L><S><P><A><K><Q><F><N><I><Y><K><K><D><F><G><K><M><T><A><N><S><V><S><V><A><T><C><E><Q><L><T><Y><Y><S><K><S><V><G><F><M><Q><W><D><N><N><G><N><T><G><N><A><T><C><F><V><F><N><G><G><Y><I><F><T><C><R><H><V><V><H><L><M><V><G><K><N><T><H><P><S><L><W><P><D><I><I><S><K><C><A><K><V><T><F><T><Y><T><E><F><C><P><T><P><D><N><W><F><S><I><E><P><W><L><K><V><S><N><E><N><L><D><Y><A><I><L><K><L><K><E><N><G><N><A><F><P><P><G><L><W><R><Q><I><S><P><Q><P><S><T><G><L><I><Y><L><I><G><H><P><E><G><Q><I><K><K><I><D><G><C><T><V><I><P><L><N><E><R><L><K><K><Y><P><N><D><C><Q><D><G><L><V><D><L><Y><D><T><T><S><N><V><Y><C><M><F><T><Q><R><S><F><L><S><E><V><W><N><T><H><T><L><S><Y><D><T><C><F><S><D><G><S><S><G><S><P><V><F><N><A><S><G><K><L><V><A><L><H><T><F><G><L><F><Y><Q><R><G><F><N><V><H><A><L><I><E><F><G><Y><S><M><D><S><I><L><C><D><I><K><K><T><N><E><S><L><Y><K><S><L><N><D><E><K><L><E><T><Y><D><E><E><K><G><K><Q><E><S><S><L><Q><D><H><Q><I><E><P><M><E><C>
|
Serine protease.<BOP>
|
Q6SJ93
|
Q15274
|
NADC_HUMAN
|
Quinolinate phosphoribosyltransferase [decarboxylating]
|
Homo
|
<M><D><A><E><G><L><A><L><L><L><P><P><V><T><L><A><A><L><V><D><S><W><L><R><E><D><C><P><G><L><N><Y><A><A><L><V><S><G><A><G><P><S><Q><A><A><L><W><A><K><S><P><G><V><L><A><G><Q><P><F><F><D><A><I><F><T><Q><L><N><C><Q><V><S><W><F><L><P><E><G><S><K><L><V><P><V><A><R><V><A><E><V><R><G><P><A><H><C><L><L><L><G><E><R><V><A><L><N><T><L><A><R><C><S><G><I><A><S><A><A><A><A><A><V><E><A><A><R><G><A><G><W><T><G><H><V><A><G><T><R><K><T><T><P><G><F><R><L><V><E><K><Y><G><L><L><V><G><G><A><A><S><H><R><Y><D><L><G><G><L><V><M><V><K><D><N><H><V><V><A><A><G><G><V><E><K><A><V><R><A><A><R><Q><A><A><D><F><T><L><K><V><E><V><E><C><S><S><L><Q><E><A><V><Q><A><A><E><A><G><A><D><L><V><L><L><D><N><F><K><P><E><E><L><H><P><T><A><T><V><L><K><A><Q><F><P><S><V><A><V><E><A><S><G><G><I><T><L><D><N><L><P><Q><F><C><G><P><H><I><D><V><I><S><M><G><M><L><T><Q><A><A><P><A><L><D><F><S><L><K><L><F><A><K><E><V><A><P><V><P><K><I><H>
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Involved in the catabolism of quinolinic acid (QA).<BOP>
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Q15274
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Q8WUU4
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ZN296_HUMAN
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Zinc finger protein 342
|
Homo
|
<M><S><R><R><K><A><G><S><A><P><R><R><V><E><P><A><P><A><A><N><P><D><D><E><M><E><M><Q><D><L><V><I><E><L><K><P><E><P><D><A><Q><P><Q><Q><A><P><R><L><G><P><F><S><P><K><E><V><S><S><A><G><R><F><G><G><E><P><H><H><S><P><G><P><M><P><A><G><A><A><L><L><A><L><G><P><R><N><P><W><T><L><W><T><P><L><T><P><N><Y><P><D><R><Q><P><W><T><D><K><H><P><D><L><L><T><C><G><R><C><L><Q><T><F><P><L><E><A><I><T><A><F><M><D><H><K><K><L><G><C><Q><L><F><R><G><P><S><R><G><Q><G><S><E><R><E><E><L><K><A><L><S><C><L><R><C><G><K><Q><F><T><V><A><W><K><L><L><R><H><A><Q><W><D><H><G><L><S><I><Y><Q><T><E><S><E><A><P><E><A><P><L><L><G><L><A><E><V><A><A><A><V><S><A><V><V><G><P><A><A><E><A><K><S><P><R><A><S><G><S><G><L><T><R><R><S><P><T><C><P><V><C><K><K><T><L><S><S><F><S><N><L><K><V><H><M><R><S><H><T><G><E><R><P><Y><A><C><D><Q><C><P><Y><A><C><A><Q><S><S><K><L><N><R><H><K><K><T><H><R><Q><V><P><P><Q><S><P><L><M><A><D><T><S><Q><E><Q><A><S><A><A><P><P><E><P><A><V><H><A><A><A><P><T><S><T><L><P><C><S><G><G><E><G><A><G><A><A><A><T><A><G><V><Q><E><P><G><A><P><G><S><G><A><Q><A><G><P><G><G><D><T><W><G><A><I><T><T><E><Q><R><T><D><P><A><N><S><Q><K><A><S><P><K><K><M><P><K><S><G><G><K><S><R><G><P><G><G><S><C><E><F><C><G><K><H><F><T><N><S><S><N><L><T><V><H><R><R><S><H><T><G><E><R><P><Y><T><C><E><F><C><N><Y><A><C><A><Q><S><S><K><L><N><R><H><R><R><M><H><G><M><T><P><G><S><T><R><F><E><C><P><H><C><H><V><P><F><G><L><R><A><T><L><D><K><H><L><R><Q><K><H><P><E><A><A><G><E><A>
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May be a transcriptional corepressor with KLF4.<BOP>
|
Q8WUU4
|
A0A0B4J1X5
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HV374_HUMAN
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Immunoglobulin heavy variable 3-74
|
Homo
|
<M><E><F><G><L><S><W><V><F><L><V><A><I><L><K><G><V><Q><C><E><V><Q><L><V><E><S><G><G><G><L><V><Q><P><G><G><S><L><R><L><S><C><A><A><S><G><F><T><F><S><S><Y><W><M><H><W><V><R><Q><A><P><G><K><G><L><V><W><V><S><R><I><N><S><D><G><S><S><T><S><Y><A><D><S><V><K><G><R><F><T><I><S><R><D><N><A><K><N><T><L><Y><L><Q><M><N><S><L><R><A><E><D><T><A><V><Y><Y><C><A><R>
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V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
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A0A0B4J1X5
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Q8NGK6
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O52I1_HUMAN
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Olfactory receptor OR11-13
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Homo
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<M><L><G><P><A><Y><N><H><T><M><E><T><P><A><S><F><L><L><V><G><I><P><G><L><Q><S><S><H><L><W><L><A><I><S><L><S><A><M><Y><I><T><A><L><L><G><N><T><L><I><V><T><A><I><W><M><D><S><T><R><H><E><P><M><Y><C><F><L><C><V><L><A><A><V><D><I><V><M><A><S><S><V><V><P><K><M><V><S><I><F><C><S><G><D><S><S><I><S><F><S><A><C><F><T><Q><M><F><F><V><H><L><A><T><A><V><E><T><G><L><L><L><T><M><A><F><D><R><Y><V><A><I><C><K><P><L><H><Y><K><R><I><L><T><P><Q><V><M><L><G><M><S><M><A><V><T><I><R><A><V><T><F><M><T><P><L><S><W><M><M><N><H><L><P><F><C><G><S><N><V><V><V><H><S><Y><C><K><H><I><A><L><A><R><L><A><C><A><D><P><V><P><S><S><L><Y><S><L><I><G><S><S><L><M><V><G><S><D><V><A><F><I><A><A><S><Y><I><L><I><L><R><A><V><F><D><L><S><S><K><T><A><Q><L><K><A><L><S><T><C><G><S><H><V><G><V><M><A><L><Y><Y><L><P><G><M><A><S><I><Y><A><A><W><L><G><Q><D><I><V><P><L><H><T><Q><V><L><L><A><D><L><Y><V><I><I><P><A><T><L><N><P><I><I><Y><G><M><R><T><K><Q><L><L><E><G><I><W><S><Y><L><M><H><F><L><F><D><H><S><N><L><G><S>
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Odorant receptor.<BOP>
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Q8NGK6
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Q96RC9
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OR8B4_HUMAN
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Olfactory receptor OR11-315
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Homo
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<M><T><L><R><N><S><S><S><V><T><E><F><I><L><V><G><L><S><E><Q><P><E><L><Q><L><P><L><F><L><L><F><L><G><I><Y><V><F><T><V><V><G><N><L><G><L><I><T><L><I><G><I><N><P><S><L><H><T><P><M><Y><F><F><L><F><N><L><S><F><I><D><L><C><Y><S><C><V><F><T><P><K><M><L><N><D><F><V><S><E><S><I><I><S><Y><V><G><C><M><T><Q><L><F><F><F><C><F><F><V><N><S><E><C><Y><V><L><V><S><M><A><Y><D><R><Y><V><A><I><C><N><P><L><L><Y><M><V><T><M><S><P><R><V><C><F><L><L><M><F><G><S><Y><V><V><G><F><A><G><A><M><A><H><T><G><S><M><L><R><L><T><F><C><D><S><N><V><I><D><H><Y><L><C><D><V><L><P><L><L><Q><L><S><C><T><S><T><H><V><S><E><L><V><F><F><I><V><V><G><V><I><T><M><L><S><S><I><S><I><V><I><S><Y><A><L><I><L><S><N><I><L><C><I><P><S><A><E><G><R><S><K><A><F><S><T><W><G><S><H><I><I><A><V><A><L><F><F><G><S><G><T><F><T><Y><L><T><T><S><F><P><G><S><M><N><H><G><R><F><A><S><V><F><Y><T><N><V><V><P><M><L><N><P><S><I><Y><S><L><R><N><K><D><D><K><L><A><L><G><K><T><L><K><R><V><L><F>
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Odorant receptor.<BOP>
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Q96RC9
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P01229
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LSHB_HUMAN
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Luteinizing hormone subunit beta
|
Homo
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<M><E><M><L><Q><G><L><L><L><L><L><L><L><S><M><G><G><A><W><A><S><R><E><P><L><R><P><W><C><H><P><I><N><A><I><L><A><V><E><K><E><G><C><P><V><C><I><T><V><N><T><T><I><C><A><G><Y><C><P><T><M><M><R><V><L><Q><A><V><L><P><P><L><P><Q><V><V><C><T><Y><R><D><V><R><F><E><S><I><R><L><P><G><C><P><R><G><V><D><P><V><V><S><F><P><V><A><L><S><C><R><C><G><P><C><R><R><S><T><S><D><C><G><G><P><K><D><H><P><L><T><C><D><H><P><Q><L><S><G><L><L><F><L>
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Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.<BOP>
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P01229
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A0A576
|
TVB31_HUMAN
|
T cell receptor beta variable 3-1
|
Homo
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<M><G><C><R><L><L><C><C><V><V><F><C><L><L><Q><A><G><P><L><D><T><A><V><S><Q><T><P><K><Y><L><V><T><Q><M><G><N><D><K><S><I><K><C><E><Q><N><L><G><H><D><T><M><Y><W><Y><K><Q><D><S><K><K><F><L><K><I><M><F><S><Y><N><N><K><E><L><I><I><N><E><T><V><P><N><R><F><S><P><K><S><P><D><K><A><H><L><N><L><H><I><N><S><L><E><L><G><D><S><A><V><Y><F><C><A><S><S><Q>
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V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
|
A0A576
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Q9H4Y5
|
GSTO2_HUMAN
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Monomethylarsonic acid reductase
|
Homo
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<M><S><G><D><A><T><R><T><L><G><K><G><S><Q><P><P><G><P><V><P><E><G><L><I><R><I><Y><S><M><R><F><C><P><Y><S><H><R><T><R><L><V><L><K><A><K><D><I><R><H><E><V><V><N><I><N><L><R><N><K><P><E><W><Y><Y><T><K><H><P><F><G><H><I><P><V><L><E><T><S><Q><C><Q><L><I><Y><E><S><V><I><A><C><E><Y><L><D><D><A><Y><P><G><R><K><L><F><P><Y><D><P><Y><E><R><A><R><Q><K><M><L><L><E><L><F><C><K><V><P><H><L><T><K><E><C><L><V><A><L><R><C><G><R><E><C><T><N><L><K><A><A><L><R><Q><E><F><S><N><L><E><E><I><L><E><Y><Q><N><T><T><F><F><G><G><T><C><I><S><M><I><D><Y><L><L><W><P><W><F><E><R><L><D><V><Y><G><I><L><D><C><V><S><H><T><P><A><L><R><L><W><I><S><A><M><K><W><D><P><T><V><C><A><L><L><M><D><K><S><I><F><Q><G><F><L><N><L><Y><F><Q><N><N><P><N><A><F><D><F><G><L><C>
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Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).<BOP>
|
Q9H4Y5
|
Q401N2
|
ZACN_HUMAN
|
Ligand-gated ion-channel receptor L2
|
Homo
|
<M><M><A><L><W><S><L><L><H><L><T><F><L><G><F><S><I><T><L><L><L><V><H><G><Q><G><F><Q><G><T><A><A><I><W><P><S><L><F><N><V><N><L><S><K><K><V><Q><E><S><I><Q><I><P><N><N><G><S><A><P><L><L><V><D><V><R><V><F><V><S><N><V><F><N><V><D><I><L><R><Y><T><M><S><S><M><L><L><L><R><L><S><W><L><D><T><R><L><A><W><N><T><S><A><H><P><R><H><A><I><T><L><P><W><E><S><L><W><T><P><R><L><T><I><L><E><A><L><W><V><D><W><R><D><Q><S><P><Q><A><R><V><D><Q><D><G><H><V><K><L><N><L><A><L><A><T><E><T><N><C><N><F><E><L><L><H><F><P><R><D><H><S><N><C><S><L><S><F><Y><A><L><S><N><T><A><M><E><L><E><F><Q><A><H><V><V><N><E><I><V><S><V><K><R><E><Y><V><V><Y><D><L><K><T><Q><V><P><P><Q><Q><L><V><P><C><F><Q><V><T><L><R><L><K><N><T><A><L><K><S><I><I><A><L><L><V><P><A><E><A><L><L><L><A><D><V><C><G><G><L><L><P><L><R><A><I><E><R><I><G><Y><K><V><T><L><L><L><S><Y><L><V><L><H><S><S><L><V><Q><A><L><P><S><S><S><S><C><N><P><L><L><I><Y><Y><F><T><I><L><L><L><L><L><F><L><S><T><I><E><T><V><L><L><A><G><L><L><A><R><G><N><L><G><A><K><S><G><P><S><P><A><P><R><G><E><Q><R><E><H><G><N><P><G><P><H><P><A><E><E><P><S><R><G><V><K><G><S><Q><R><S><W><P><E><T><A><D><R><I><F><F><L><V><Y><V><V><G><V><L><C><T><Q><F><V><F><A><G><I><W><M><W><A><A><C><K><S><D><A><A><P><G><E><A><A><P><H><G><R><R><P><R><L>
|
Zinc-activated ligand-gated ion channel.<BOP>
|
Q401N2
|
Q9NUD5
|
ZCHC3_HUMAN
|
Zinc finger CCHC domain-containing protein 3
|
Homo
|
<M><A><T><G><G><G><A><E><E><E><R><K><R><G><R><P><Q><L><L><P><P><A><R><P><A><A><R><G><E><E><A><D><G><G><R><E><K><M><G><W><A><Q><V><V><K><N><L><A><E><K><K><G><E><F><R><E><P><R><P><P><R><R><E><E><E><S><G><G><G><G><G><S><A><G><L><G><G><P><A><G><L><A><A><P><D><L><G><D><F><P><P><A><G><R><G><D><P><K><G><R><R><R><D><P><A><G><E><A><V><D><P><R><K><K><K><G><A><A><E><A><G><R><R><K><K><A><E><A><A><A><A><A><M><A><T><P><A><R><P><G><E><A><E><D><A><A><E><R><P><L><Q><D><E><P><A><A><A><A><G><P><G><K><G><R><F><L><V><R><I><C><F><Q><G><D><E><G><A><C><P><T><R><D><F><V><V><G><A><L><I><L><R><S><I><G><M><D><P><S><D><I><Y><A><V><I><Q><I><P><G><S><R><E><F><D><V><S><F><R><S><A><E><K><L><A><L><F><L><R><V><Y><E><E><K><R><E><Q><E><D><C><W><E><N><F><V><V><L><G><R><S><K><S><S><L><K><T><L><F><I><L><F><R><N><E><T><V><D><V><E><D><I><V><T><W><L><K><R><H><C><D><V><L><A><V><P><V><K><V><T><D><R><F><G><I><W><T><G><E><Y><K><C><E><I><E><L><R><Q><G><E><G><G><V><R><H><L><P><G><A><F><F><L><G><A><E><R><G><Y><S><W><Y><K><G><Q><P><K><T><C><F><K><C><G><S><R><T><H><M><S><G><S><C><T><Q><D><R><C><F><R><C><G><E><E><G><H><L><S><P><Y><C><R><K><G><I><V><C><N><L><C><G><K><R><G><H><A><F><A><Q><C><P><K><A><V><H><N><S><V><A><A><Q><L><T><G><V><A><G><H>
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Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses . Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS . Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus . Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation . Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58/RIG-I and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of DDX58/RIG-I and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58/RIG-I and IFIH1/MDA5 .<BOP>
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Q9NUD5
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Q96QV1
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HHIP_HUMAN
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Hedgehog-interacting protein
|
Homo
|
<M><L><K><M><L><S><F><K><L><L><L><L><A><V><A><L><G><F><F><E><G><D><A><K><F><G><E><R><N><E><G><S><G><A><R><R><R><R><C><L><N><G><N><P><P><K><R><L><K><R><R><D><R><R><M><M><S><Q><L><E><L><L><S><G><G><E><M><L><C><G><G><F><Y><P><R><L><S><C><C><L><R><S><D><S><P><G><L><G><R><L><E><N><K><I><F><S><V><T><N><N><T><E><C><G><K><L><L><E><E><I><K><C><A><L><C><S><P><H><S><Q><S><L><F><H><S><P><E><R><E><V><L><E><R><D><L><V><L><P><L><L><C><K><D><Y><C><K><E><F><F><Y><T><C><R><G><H><I><P><G><F><L><Q><T><T><A><D><E><F><C><F><Y><Y><A><R><K><D><G><G><L><C><F><P><D><F><P><R><K><Q><V><R><G><P><A><S><N><Y><L><D><Q><M><E><E><Y><D><K><V><E><E><I><S><R><K><H><K><H><N><C><F><C><I><Q><E><V><V><S><G><L><R><Q><P><V><G><A><L><H><S><G><D><G><S><Q><R><L><F><I><L><E><K><E><G><Y><V><K><I><L><T><P><E><G><E><I><F><K><E><P><Y><L><D><I><H><K><L><V><Q><S><G><I><K><G><G><D><E><R><G><L><L><S><L><A><F><H><P><N><Y><K><K><N><G><K><L><Y><V><S><Y><T><T><N><Q><E><R><W><A><I><G><P><H><D><H><I><L><R><V><V><E><Y><T><V><S><R><K><N><P><H><Q><V><D><L><R><T><A><R><V><F><L><E><V><A><E><L><H><R><K><H><L><G><G><Q><L><L><F><G><P><D><G><F><L><Y><I><I><L><G><D><G><M><I><T><L><D><D><M><E><E><M><D><G><L><S><D><F><T><G><S><V><L><R><L><D><V><D><T><D><M><C><N><V><P><Y><S><I><P><R><S><N><P><H><F><N><S><T><N><Q><P><P><E><V><F><A><H><G><L><H><D><P><G><R><C><A><V><D><R><H><P><T><D><I><N><I><N><L><T><I><L><C><S><D><S><N><G><K><N><R><S><S><A><R><I><L><Q><I><I><K><G><K><D><Y><E><S><E><P><S><L><L><E><F><K><P><F><S><N><G><P><L><V><G><G><F><V><Y><R><G><C><Q><S><E><R><L><Y><G><S><Y><V><F><G><D><R><N><G><N><F><L><T><L><Q><Q><S><P><V><T><K><Q><W><Q><E><K><P><L><C><L><G><T><S><G><S><C><R><G><Y><F><S><G><H><I><L><G><F><G><E><D><E><L><G><E><V><Y><I><L><S><S><S><K><S><M><T><Q><T><H><N><G><K><L><Y><K><I><V><D><P><K><R><P><L><M><P><E><E><C><R><A><T><V><Q><P><A><Q><T><L><T><S><E><C><S><R><L><C><R><N><G><Y><C><T><P><T><G><K><C><C><C><S><P><G><W><E><G><D><F><C><R><T><A><K><C><E><P><A><C><R><H><G><G><V><C><V><R><P><N><K><C><L><C><K><K><G><Y><L><G><P><Q><C><E><Q><V><D><R><N><I><R><R><V><T><R><A><G><I><L><D><Q><I><I><D><M><T><S><Y><L><L><D><L><T><S><Y><I><V>
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Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.<BOP>
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Q96QV1
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Q9Y2Z0
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SGT1_HUMAN
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Suppressor of G2 allele of SKP1 homolog
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Homo
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<M><A><A><A><A><A><G><T><A><T><S><Q><R><F><F><Q><S><F><S><D><A><L><I><D><E><D><P><Q><A><A><L><E><E><L><T><K><A><L><E><Q><K><P><D><D><A><Q><Y><Y><C><Q><R><A><Y><C><H><I><L><L><G><N><Y><C><V><A><V><A><D><A><K><K><S><L><E><L><N><P><N><N><S><T><A><M><L><R><K><G><I><C><E><Y><H><E><K><N><Y><A><A><A><L><E><T><F><T><E><G><Q><K><L><D><I><E><T><G><F><H><R><V><G><Q><A><G><L><Q><L><L><T><S><S><D><P><P><A><L><D><S><Q><S><A><G><I><T><G><A><D><A><N><F><S><V><W><I><K><R><C><Q><E><A><Q><N><G><S><E><S><E><V><W><T><H><Q><S><K><I><K><Y><D><W><Y><Q><T><E><S><Q><V><V><I><T><L><M><I><K><N><V><Q><K><N><D><V><N><V><E><F><S><E><K><E><L><S><A><L><V><K><L><P><S><G><E><D><Y><N><L><K><L><E><L><L><H><P><I><I><P><E><Q><S><T><F><K><V><L><S><T><K><I><E><I><K><L><K><K><P><E><A><V><R><W><E><K><L><E><G><Q><G><D><V><P><T><P><K><Q><F><V><A><D><V><K><N><L><Y><P><S><S><S><P><Y><T><R><N><W><D><K><L><V><G><E><I><K><E><E><E><K><N><E><K><L><E><G><D><A><A><L><N><R><L><F><Q><Q><I><Y><S><D><G><S><D><E><V><K><R><A><M><N><K><S><F><M><E><S><G><G><T><V><L><S><T><N><W><S><D><V><G><K><R><K><V><E><I><N><P><P><D><D><M><E><W><K><K><Y>
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May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.<BOP>
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Q9Y2Z0
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Q969W9
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PMEPA_HUMAN
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Transmembrane prostate androgen-induced protein
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Homo
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<M><H><R><L><M><G><V><N><S><T><A><A><A><A><A><G><Q><P><N><V><S><C><T><C><N><C><K><R><S><L><F><Q><S><M><E><I><T><E><L><E><F><V><Q><I><I><I><I><V><V><V><M><M><V><M><V><V><V><I><T><C><L><L><S><H><Y><K><L><S><A><R><S><F><I><S><R><H><S><Q><G><R><R><R><E><D><A><L><S><S><E><G><C><L><W><P><S><E><S><T><V><S><G><N><G><I><P><E><P><Q><V><Y><A><P><P><R><P><T><D><R><L><A><V><P><P><F><A><Q><R><E><R><F><H><R><F><Q><P><T><Y><P><Y><L><Q><H><E><I><D><L><P><P><T><I><S><L><S><D><G><E><E><P><P><P><Y><Q><G><P><C><T><L><Q><L><R><D><P><E><Q><Q><L><E><L><N><R><E><S><V><R><A><P><P><N><R><T><I><F><D><S><D><L><M><D><S><A><R><L><G><G><P><C><P><P><S><S><N><S><G><I><S><A><T><C><Y><G><S><G><G><R><M><E><G><P><P><P><T><Y><S><E><V><I><G><H><Y><P><G><S><S><F><Q><H><Q><Q><S><S><G><P><P><S><L><L><E><G><T><R><L><H><H><T><H><I><A><P><L><E><S><A><A><I><W><S><K><E><K><D><K><Q><K><G><H><P><L>
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Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal . Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 .<BOP>
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Q969W9
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O60942
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MCE1_HUMAN
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GTP--RNA guanylyltransferase
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Homo
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<M><A><H><N><K><I><P><P><R><W><L><N><C><P><R><R><G><Q><P><V><A><G><R><F><L><P><L><K><T><M><L><G><P><R><Y><D><S><Q><V><A><E><E><N><R><F><H><P><S><M><L><S><N><Y><L><K><S><L><K><V><K><M><G><L><L><V><D><L><T><N><T><S><R><F><Y><D><R><N><D><I><E><K><E><G><I><K><Y><I><K><L><Q><C><K><G><H><G><E><C><P><T><T><E><N><T><E><T><F><I><R><L><C><E><R><F><N><E><R><N><P><P><E><L><I><G><V><H><C><T><H><G><F><N><R><T><G><F><L><I><C><A><F><L><V><E><K><M><D><W><S><I><E><A><A><V><A><T><F><A><Q><A><R><P><P><G><I><Y><K><G><D><Y><L><K><E><L><F><R><R><Y><G><D><I><E><E><A><P><P><P><P><L><L><P><D><W><C><F><E><D><D><E><D><E><D><E><D><E><D><G><K><K><E><S><E><P><G><S><S><A><S><F><G><K><R><R><K><E><R><L><K><L><G><A><I><F><L><E><G><V><T><V><K><G><V><T><Q><V><T><T><Q><P><K><L><G><E><V><Q><Q><K><C><H><Q><F><C><G><W><E><G><S><G><F><P><G><A><Q><P><V><S><M><D><K><Q><N><I><K><L><L><D><L><K><P><Y><K><V><S><W><K><A><D><G><T><R><Y><M><M><L><I><D><G><T><N><E><V><F><M><I><D><R><D><N><S><V><F><H><V><S><N><L><E><F><P><F><R><K><D><L><R><M><H><L><S><N><T><L><L><D><G><E><M><I><I><D><R><V><N><G><Q><A><V><P><R><Y><L><I><Y><D><I><I><K><F><N><S><Q><P><V><G><D><C><D><F><N><V><R><L><Q><C><I><E><R><E><I><I><S><P><R><H><E><K><M><K><T><G><L><I><D><K><T><Q><E><P><F><S><V><R><N><K><P><F><F><D><I><C><T><S><R><K><L><L><E><G><N><F><A><K><E><V><S><H><E><M><D><G><L><I><F><Q><P><T><G><K><Y><K><P><G><R><C><D><D><I><L><K><W><K><P><P><S><L><N><S><V><D><F><R><L><K><I><T><R><M><G><G><E><G><L><L><P><Q><N><V><G><L><L><Y><V><G><G><Y><E><R><P><F><A><Q><I><K><V><T><K><E><L><K><Q><Y><D><N><K><I><I><E><C><K><F><E><N><N><S><W><V><F><M><R><Q><R><T><D><K><S><F><P><N><A><Y><N><T><A><M><A><V><C><N><S><I><S><N><P><V><T><K><E><M><L><F><E><F><I><D><R><C><T><A><A><S><Q><G><Q><K><R><K><H><H><L><D><P><D><T><E><L><M><P><P><P><P><P><K><R><P><R><P><L><T>
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Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.<BOP>
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O60942
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O75069
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TMCC2_HUMAN
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Cerebral protein 11
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Homo
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<M><K><R><C><R><S><D><E><L><Q><Q><Q><Q><G><E><E><D><G><A><G><L><E><D><A><A><S><H><L><P><G><A><D><L><R><P><G><E><T><T><G><A><N><S><A><G><G><P><T><S><D><A><G><A><A><A><A><P><N><P><G><P><R><S><K><P><P><D><L><K><K><I><Q><Q><L><S><E><G><S><M><F><G><H><G><L><K><H><L><F><H><S><R><R><R><S><R><E><R><E><H><Q><T><S><Q><D><S><Q><Q><H><Q><Q><Q><Q><G><M><S><D><H><D><S><P><D><E><K><E><R><S><P><E><M><H><R><V><S><Y><A><M><S><L><H><D><L><P><A><R><P><T><A><F><N><R><V><L><Q><Q><I><R><S><R><P><S><I><K><R><G><A><S><L><H><S><S><S><G><G><G><S><S><G><S><S><S><R><R><T><K><S><S><S><L><E><P><Q><R><G><S><P><H><L><L><R><K><A><P><Q><D><S><S><L><A><A><I><L><H><Q><H><Q><C><R><P><R><S><S><S><T><T><D><T><A><L><L><L><A><D><G><S><N><V><Y><L><L><A><E><E><A><E><G><I><G><D><K><V><D><K><G><D><L><V><A><L><S><L><P><A><G><H><G><D><T><D><G><P><I><S><L><D><V><P><D><G><A><P><D><P><Q><R><T><K><A><A><I><D><H><L><H><Q><K><I><L><K><I><T><E><Q><I><K><I><E><Q><E><A><R><D><D><N><V><A><E><Y><L><K><L><A><N><N><A><D><K><Q><Q><V><S><R><I><K><Q><V><F><E><K><K><N><Q><K><S><A><Q><T><I><A><Q><L><H><K><K><L><E><H><Y><R><R><R><L><K><E><I><E><Q><N><G><P><S><R><Q><P><K><D><V><L><R><D><M><Q><Q><G><L><K><D><V><G><A><N><V><R><A><G><I><S><G><F><G><G><G><V><V><E><G><V><K><G><S><L><S><G><L><S><Q><A><T><H><T><A><V><V><S><K><P><R><E><F><A><S><L><I><R><N><K><F><G><S><A><D><N><I><A><H><L><K><D><P><L><E><D><G><P><P><E><E><A><A><R><A><L><S><G><S><A><T><L><V><S><S><P><K><Y><G><S><D><D><E><C><S><S><A><S><A><S><S><A><G><A><G><S><N><S><G><A><G><P><G><G><A><L><G><S><P><K><S><N><A><L><Y><G><A><P><G><N><L><D><A><L><L><E><E><L><R><E><I><K><E><G><Q><S><H><L><E><D><S><M><E><D><L><K><T><Q><L><Q><R><D><Y><T><Y><M><T><Q><C><L><Q><E><E><R><Y><R><Y><E><R><L><E><E><Q><L><N><D><L><T><E><L><H><Q><N><E><M><T><N><L><K><Q><E><L><A><S><M><E><E><K><V><A><Y><Q><S><Y><E><R><A><R><D><I><Q><E><A><V><E><S><C><L><T><R><V><T><K><L><E><L><Q><Q><Q><Q><Q><Q><V><V><Q><L><E><G><V><E><N><A><N><A><R><A><L><L><G><K><F><I><N><V><I><L><A><L><M><A><V><L><L><V><F><V><S><T><I><A><N><F><I><T><P><L><M><K><T><R><L><R><I><T><S><T><T><L><L><V><L><V><L><F><L><L><W><K><H><W><D><S><L><T><Y><L><L><E><H><V><L><L><P><S>
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May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE.<BOP>
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O75069
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P62861
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RS30_HUMAN
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Small ribosomal subunit protein eS30
|
Homo
|
<M><Q><L><F><V><R><A><Q><E><L><H><T><F><E><V><T><G><Q><E><T><V><A><Q><I><K><A><H><V><A><S><L><E><G><I><A><P><E><D><Q><V><V><L><L><A><G><A><P><L><E><D><E><A><T><L><G><Q><C><G><V><E><A><L><T><T><L><E><V><A><G><R><M><L><G><G><K><V><H><G><S><L><A><R><A><G><K><V><R><G><Q><T><P><K><V><A><K><Q><E><K><K><K><K><K><T><G><R><A><K><R><R><M><Q><Y><N><R><R><F><V><N><V><V><P><T><F><G><K><K><K><G><P><N><A><N><S>
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Component of the 40S subunit of the ribosome. Contributes to the assembly and function of 40S ribosomal subunits.<BOP>
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P62861
|
Q96SR6
|
ZN382_HUMAN
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Multiple zinc finger and krueppel-associated box protein KS1
|
Homo
|
<M><P><L><Q><G><S><V><S><F><K><D><V><T><V><D><F><T><Q><E><E><W><Q><Q><L><D><P><A><Q><K><A><L><Y><R><D><V><M><L><E><N><Y><C><H><F><V><S><V><G><F><H><M><A><K><P><D><M><I><R><K><L><E><Q><G><E><E><L><W><T><Q><R><I><F><P><S><Y><S><Y><L><E><E><D><G><K><T><E><D><V><L><V><K><F><K><E><Y><Q><D><R><H><S><R><P><L><I><F><I><N><H><K><K><L><I><K><E><R><S><N><I><Y><G><K><T><F><T><L><G><K><N><R><I><S><K><T><I><L><C><E><Y><K><P><D><G><K><V><L><K><N><I><S><E><L><V><I><R><N><I><S><P><I><K><E><K><F><G><D><S><T><G><W><E><K><S><L><L><N><T><K><H><E><K><I><H><P><A><V><N><L><H><K><Q><T><E><R><V><L><S><G><K><Q><E><L><I><Q><H><Q><K><V><Q><A><P><E><Q><P><F><D><H><N><E><C><E><K><S><F><L><M><K><G><M><L><F><T><H><T><R><A><H><R><G><E><R><T><F><E><Y><N><K><D><G><I><A><F><I><E><K><S><S><L><S><V><H><P><S><N><L><M><E><K><K><P><S><A><Y><N><K><Y><G><K><F><L><C><R><K><P><V><F><I><M><P><Q><R><P><Q><T><E><E><K><P><F><H><C><P><Y><C><G><N><N><F><R><R><K><S><Y><L><I><E><H><Q><R><I><H><T><G><E><K><P><Y><V><C><N><Q><C><G><K><A><F><R><Q><K><T><A><L><T><L><H><E><K><T><H><I><E><G><K><P><F><I><C><I><D><C><G><K><S><F><R><Q><K><A><T><L><T><R><H><H><K><T><H><T><G><E><K><A><Y><E><C><P><Q><C><G><S><A><F><R><K><K><S><Y><L><I><D><H><Q><R><T><H><T><G><E><K><P><Y><Q><C><N><E><C><G><K><A><F><I><Q><K><T><T><L><T><V><H><Q><R><T><H><T><G><E><K><P><Y><I><C><N><E><C><G><K><S><F><C><Q><K><T><T><L><T><L><H><Q><R><I><H><T><G><E><K><P><Y><I><C><N><E><C><G><K><S><F><R><Q><K><A><I><L><T><V><H><H><R><I><H><T><G><E><K><S><N><G><C><P><Q><C><G><K><A><F><S><R><K><S><N><L><I><R><H><Q><K><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><F><F><S><C><K><S><N><L><I><V><H><Q><K><T><H><K><V><E><T><T><G><I><Q>
|
Functions as a sequence-specific transcriptional repressor.<BOP>
|
Q96SR6
|
Q9P2G9
|
KLHL8_HUMAN
|
Kelch-like protein 8
|
Homo
|
<M><A><S><D><S><M><S><S><K><Q><A><R><N><H><I><T><K><G><K><R><Q><Q><Q><H><Q><Q><I><K><N><R><S><S><I><S><D><G><D><G><E><D><S><F><I><F><E><A><N><E><A><W><K><D><F><H><G><S><L><L><R><F><Y><E><N><G><E><L><C><D><V><T><L><K><V><G><S><K><L><I><S><C><H><K><L><V><L><A><C><V><I><P><Y><F><R><A><M><F><L><S><E><M><A><E><A><K><Q><T><L><I><E><I><R><D><F><D><G><D><A><I><E><D><L><V><K><F><V><Y><S><S><R><L><T><L><T><V><D><N><V><Q><P><L><L><Y><A><A><C><I><L><Q><V><E><L><V><A><R><A><C><C><E><Y><M><K><L><H><F><H><P><S><N><C><L><A><V><R><A><F><A><E><S><H><N><R><I><D><L><M><D><M><A><D><Q><Y><A><C><D><H><F><T><E><V><V><E><C><E><D><F><V><S><V><S><P><Q><H><L><H><K><L><L><S><S><S><D><L><N><I><E><N><E><K><Q><V><Y><N><A><A><I><K><W><L><L><A><N><P><Q><H><H><S><K><W><L><D><E><T><L><A><Q><V><R><L><P><L><L><P><V><D><F><L><M><G><V><V><A><K><E><Q><I><V><K><Q><N><L><K><C><R><D><L><L><D><E><A><R><N><Y><H><L><H><L><S><S><R><A><V><P><D><F><E><Y><S><I><R><T><T><P><R><K><H><T><A><G><V><L><F><C><V><G><G><R><G><G><S><G><D><P><F><R><S><I><E><C><Y><S><I><N><K><N><S><W><F><F><G><P><E><M><N><S><R><R><R><H><V><G><V><I><S><V><E><G><K><V><Y><A><V><G><G><H><D><G><N><E><H><L><G><S><M><E><M><F><D><P><L><T><N><K><W><M><M><K><A><S><M><N><T><K><R><R><G><I><A><L><A><S><L><G><G><P><I><Y><A><I><G><G><L><D><D><N><T><C><F><N><D><V><E><R><Y><D><I><E><S><D><Q><W><S><T><V><A><P><M><N><T><P><R><G><G><V><G><S><V><A><L><V><N><H><V><Y><A><V><G><G><N><D><G><M><A><S><L><S><S><V><E><R><Y><D><P><H><L><D><K><W><I><E><V><K><E><M><G><Q><R><R><A><G><N><G><V><S><K><L><H><G><C><L><Y><V><V><G><G><F><D><D><N><S><P><L><S><S><V><E><R><Y><D><P><R><S><N><K><W><D><Y><V><A><A><L><T><T><P><R><G><G><V><G><I><A><T><V><M><G><K><I><F><A><V><G><G><H><N><G><N><A><Y><L><N><T><V><E><A><F><D><P><V><L><N><R><W><E><L><V><G><S><V><S><H><C><R><A><G><A><G><V><A><V><C><S><C><L><T><S><Q><I><R><D><V><G><H><G><S><N><N><V><V><D><C><M>
|
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.<BOP>
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Q9P2G9
|
Q96T83
|
SL9A7_HUMAN
|
Solute carrier family 9 member 7
|
Homo
|
<M><E><P><G><D><A><A><R><P><G><S><G><R><A><T><G><A><P><P><P><R><L><L><L><L><P><L><L><L><G><W><G><L><R><V><A><A><A><A><S><A><S><S><S><G><A><A><A><E><D><S><S><A><M><E><E><L><A><T><E><K><E><A><E><E><S><H><R><Q><D><S><V><S><L><L><T><F><I><L><L><L><T><L><T><I><L><T><I><W><L><F><K><H><R><R><V><R><F><L><H><E><T><G><L><A><M><I><Y><G><L><I><V><G><V><I><L><R><Y><G><T><P><A><T><S><G><R><D><K><S><L><S><C><T><Q><E><D><R><A><F><S><T><L><L><V><N><V><S><G><K><F><F><E><Y><T><L><K><G><E><I><S><P><G><K><I><N><S><V><E><Q><N><D><M><L><R><K><V><T><F><D><P><E><V><F><F><N><I><L><L><P><P><I><I><F><H><A><G><Y><S><L><K><K><R><H><F><F><R><N><L><G><S><I><L><A><Y><A><F><L><G><T><A><V><S><C><F><I><I><G><N><L><M><Y><G><V><V><K><L><M><K><I><M><G><Q><L><S><D><K><F><Y><Y><T><D><C><L><F><F><G><A><I><I><S><A><T><D><P><V><T><V><L><A><I><F><N><E><L><H><A><D><V><D><L><Y><A><L><L><F><G><E><S><V><L><N><D><A><V><A><I><V><L><S><S><S><I><V><A><Y><Q><P><A><G><L><N><T><H><A><F><D><A><A><A><F><F><K><S><V><G><I><F><L><G><I><F><S><G><S><F><T><M><G><A><V><T><G><V><N><A><N><V><T><K><F><T><K><L><H><C><F><P><L><L><E><T><A><L><F><F><L><M><S><W><S><T><F><L><L><A><E><A><C><G><F><T><G><V><V><A><V><L><F><C><G><I><T><Q><A><H><Y><T><Y><N><N><L><S><V><E><S><R><S><R><T><K><Q><L><F><E><V><L><H><F><L><A><E><N><F><I><F><S><Y><M><G><L><A><L><F><T><F><Q><K><H><V><F><S><P><I><F><I><I><G><A><F><V><A><I><F><L><G><R><A><A><H><I><Y><P><L><S><F><F><L><N><L><G><R><R><H><K><I><G><W><N><F><Q><H><M><M><M><F><S><G><L><R><G><A><M><A><F><A><L><A><I><R><D><T><A><S><Y><A><R><Q><M><M><F><T><T><T><L><L><I><V><F><F><T><V><W><I><I><G><G><G><T><T><P><M><L><S><W><L><N><I><R><V><G><V><E><E><P><S><E><E><D><Q><N><E><H><H><W><Q><Y><F><R><V><G><V><D><P><D><Q><D><P><P><P><N><N><D><S><F><Q><V><L><Q><G><D><G><P><D><S><A><R><G><N><R><T><K><Q><E><S><A><W><I><F><R><L><W><Y><S><F><D><H><N><Y><L><K><P><I><L><T><H><S><G><P><P><L><T><T><T><L><P><A><W><C><G><L><L><A><R><C><L><T><S><P><Q><V><Y><D><N><Q><E><P><L><R><E><E><D><S><D><F><I><L><T><E><G><D><L><T><L><T><Y><G><D><S><T><V><T><A><N><G><S><S><S><S><H><T><A><S><T><S><L><E><G><S><R><R><T><K><S><S><S><E><E><V><L><E><R><D><L><G><M><G><D><Q><K><V><S><S><R><G><T><R><L><V><F><P><L><E><D><N><A>
|
Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to the regulation of Golgi apparatus volume and pH.<BOP>
|
Q96T83
|
Q9HCN6
|
GPVI_HUMAN
|
Glycoprotein 6
|
Homo
|
<M><S><P><S><P><T><A><L><F><C><L><G><L><C><L><G><R><V><P><A><Q><S><G><P><L><P><K><P><S><L><Q><A><L><P><S><S><L><V><P><L><E><K><P><V><T><L><R><C><Q><G><P><P><G><V><D><L><Y><R><L><E><K><L><S><S><S><R><Y><Q><D><Q><A><V><L><F><I><P><A><M><K><R><S><L><A><G><R><Y><R><C><S><Y><Q><N><G><S><L><W><S><L><P><S><D><Q><L><E><L><V><A><T><G><V><F><A><K><P><S><L><S><A><Q><P><G><P><A><V><S><S><G><G><D><V><T><L><Q><C><Q><T><R><Y><G><F><D><Q><F><A><L><Y><K><E><G><D><P><A><P><Y><K><N><P><E><R><W><Y><R><A><S><F><P><I><I><T><V><T><A><A><H><S><G><T><Y><R><C><Y><S><F><S><S><R><D><P><Y><L><W><S><A><P><S><D><P><L><E><L><V><V><T><G><T><S><V><T><P><S><R><L><P><T><E><P><P><S><P><V><A><E><F><S><E><A><T><A><E><L><T><V><S><F><T><N><E><V><F><T><T><E><T><S><R><S><I><T><A><S><P><K><E><S><D><S><P><A><G><P><A><R><Q><Y><Y><T><K><G><N><L><V><R><I><C><L><G><A><V><I><L><I><I><L><A><G><F><L><A><E><D><W><H><S><R><R><K><R><L><R><H><R><G><R><A><V><Q><R><P><L><P><P><L><P><P><L><P><L><T><R><K><S><N><G><G><Q><D><G><G><R><Q><D><V><H><S><R><G><L><C><S>
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Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.<BOP>
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Q9HCN6
|
Q14802
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FXYD3_HUMAN
|
Sodium/potassium-transporting ATPase subunit FXYD3
|
Homo
|
<M><Q><K><V><T><L><G><L><L><V><F><L><A><G><F><P><V><L><D><A><N><D><L><E><D><K><N><S><P><F><Y><Y><D><W><H><S><L><Q><V><G><G><L><I><C><A><G><V><L><C><A><M><G><I><I><I><V><M><S><A><K><C><K><C><K><F><G><Q><K><S><G><H><H><P><G><E><T><P><P><L><I><T><P><G><S><A><Q><S>
|
Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials.<BOP>
|
Q14802
|
Q15007
|
FL2D_HUMAN
|
Wilms tumor 1-associating protein
|
Homo
|
<M><T><N><E><E><P><L><P><K><K><V><R><L><S><E><T><D><F><K><V><M><A><R><D><E><L><I><L><R><W><K><Q><Y><E><A><Y><V><Q><A><L><E><G><K><Y><T><D><L><N><S><N><D><V><T><G><L><R><E><S><E><E><K><L><K><Q><Q><Q><Q><E><S><A><R><R><E><N><I><L><V><M><R><L><A><T><K><E><Q><E><M><Q><E><C><T><T><Q><I><Q><Y><L><K><Q><V><Q><Q><P><S><V><A><Q><L><R><S><T><M><V><D><P><A><I><N><L><F><F><L><K><M><K><G><E><L><E><Q><T><K><D><K><L><E><Q><A><Q><N><E><L><S><A><W><K><F><T><P><D><S><Q><T><G><K><K><L><M><A><K><C><R><M><L><I><Q><E><N><Q><E><L><G><R><Q><L><S><Q><G><R><I><A><Q><L><E><A><E><L><A><L><Q><K><K><Y><S><E><E><L><K><S><S><Q><D><E><L><N><D><F><I><I><Q><L><D><E><E><V><E><G><M><Q><S><T><I><L><V><L><Q><Q><Q><L><K><E><T><R><Q><Q><L><A><Q><Y><Q><Q><Q><Q><S><Q><A><S><A><P><S><T><S><R><T><T><A><S><E><P><V><E><Q><S><E><A><T><S><K><D><C><S><R><L><T><N><G><P><S><N><G><S><S><S><R><Q><R><T><S><G><S><G><F><H><R><E><G><N><T><T><E><D><D><F><P><S><S><P><G><N><G><N><K><S><S><N><S><S><E><E><R><T><G><R><G><G><S><G><Y><V><N><Q><L><S><A><G><Y><E><S><V><D><S><P><T><G><S><E><N><S><L><T><H><Q><S><N><D><T><D><S><S><H><D><P><Q><E><E><K><A><V><S><G><K><G><N><R><T><V><G><S><R><H><V><Q><N><G><L><D><S><S><V><N><V><Q><G><S><V><L>
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Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Required for accumulation of METTL3 and METTL14 to nuclear speckle . Acts as a mRNA splicing regulator . Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability . Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes .<BOP>
|
Q15007
|
Q4JDL3
|
PTN20_HUMAN
|
Tyrosine-protein phosphatase non-receptor type 20
|
Homo
|
<M><S><S><P><R><D><F><R><A><E><P><V><N><D><Y><E><G><N><D><S><E><A><E><D><L><N><F><R><E><T><L><P><S><S><S><Q><E><N><T><P><R><S><K><V><F><E><N><K><V><N><S><E><K><V><K><L><S><L><R><N><F><P><H><N><D><Y><E><D><V><F><E><E><P><S><E><S><G><S><D><P><S><M><W><T><A><R><G><P><F><R><R><D><R><W><S><S><E><D><E><E><A><A><G><P><S><Q><A><L><S><P><L><L><S><D><T><R><K><I><V><S><E><G><E><L><D><Q><L><A><Q><I><R><P><L><I><F><N><F><H><E><Q><T><A><I><K><D><C><L><K><I><L><E><E><K><T><A><A><Y><D><I><M><Q><E><F><M><A><L><E><L><K><N><L><P><G><E><F><N><S><G><N><Q><P><S><N><R><E><K><N><R><Y><R><D><I><L><P><Y><D><S><T><R><V><P><L><G><K><S><K><D><Y><I><N><A><S><Y><I><R><I><V><N><C><G><E><E><Y><F><Y><I><A><T><Q><G><P><L><L><S><T><I><D><D><F><W><Q><M><V><L><E><N><N><S><N><V><I><A><M><I><T><R><E><I><E><G><G><I><I><K><C><Y><H><Y><W><P><I><S><L><K><K><P><L><E><L><K><H><F><R><V><F><L><E><N><Y><Q><I><L><Q><Y><F><I><I><R><M><F><Q><V><V><E><K><S><T><G><T><S><H><S><V><K><Q><L><Q><F><T><K><W><P><D><H><G><T><P><A><S><A><D><S><F><I><K><Y><I><R><Y><A><R><K><S><H><L><T><G><P><M><V><V><H><C><S><A><G><I><G><R><T><G><V><F><L><C><V><D><V><V><F><C><A><I><V><K><N><C><S><F><N><I><M><D><I><V><A><Q><M><R><E><Q><R><S><G><M><V><Q><T><K><E><Q><Y><H><F><C><Y><D><I><V><L><E><V><L><R><K><L><L><T><L><D>
|
Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.<BOP>
|
Q4JDL3
|
Q9NVZ3
|
NECP2_HUMAN
|
NECAP endocytosis-associated protein 2
|
Homo
|
<M><E><E><S><G><Y><E><S><V><L><C><V><K><P><D><V><H><V><Y><R><I><P><P><R><A><T><N><R><G><Y><R><A><A><E><W><Q><L><D><Q><P><S><W><S><G><R><L><R><I><T><A><K><G><Q><M><A><Y><I><K><L><E><D><R><T><S><G><E><L><F><A><Q><A><P><V><D><Q><F><P><G><T><A><V><E><S><V><T><D><S><S><R><Y><F><V><I><R><I><E><D><G><N><G><R><R><A><F><I><G><I><G><F><G><D><R><G><D><A><F><D><F><N><V><A><L><Q><D><H><F><K><W><V><K><Q><Q><C><E><F><A><K><Q><A><Q><N><P><D><Q><G><P><K><L><D><L><G><F><K><E><G><Q><T><I><K><L><N><I><A><N><M><K><K><K><E><G><A><A><G><N><P><R><V><R><P><A><S><T><G><G><L><S><L><L><P><P><P><P><G><G><K><T><S><T><L><I><P><P><P><G><E><Q><L><A><V><G><G><S><L><V><Q><P><A><V><A><P><S><S><G><G><A><P><V><P><W><P><Q><P><N><P><A><T><A><D><I><W><G><D><F><T><K><S><T><G><S><T><S><S><Q><T><Q><P><G><T><G><W><V><Q><F>
|
Involved in endocytosis.<BOP>
|
Q9NVZ3
|
P05161
|
ISG15_HUMAN
|
Ubiquitin cross-reactive protein
|
Homo
|
<M><G><W><D><L><T><V><K><M><L><A><G><N><E><F><Q><V><S><L><S><S><S><M><S><V><S><E><L><K><A><Q><I><T><Q><K><I><G><V><H><A><F><Q><Q><R><L><A><V><H><P><S><G><V><A><L><Q><D><R><V><P><L><A><S><Q><G><L><G><P><G><S><T><V><L><L><V><V><D><K><C><D><E><P><L><S><I><L><V><R><N><N><K><G><R><S><S><T><Y><E><V><R><L><T><Q><T><V><A><H><L><K><Q><Q><V><S><G><L><E><G><V><Q><D><D><L><F><W><L><T><F><E><G><K><P><L><E><D><Q><L><P><L><G><E><Y><G><L><K><P><L><S><T><V><F><M><N><L><R><L><R><G><G><G><T><E><P><G><G><R><S>
|
Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein . Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6. Isgylation of the viral sensor IFIH1/MDA5 promotes IFIH1/MDA5 oligomerization and triggers activation of innate immunity against a range of viruses, including coronaviruses, flaviviruses and picornaviruses . Can also isgylate: EIF2AK2/PKR which results in its activation, DDX58/RIG-I which inhibits its function in antiviral signaling response, EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity, UBE2N and UBE2E1 which negatively regulates
|
P05161
|
Q9H205
|
O2AG1_HUMAN
|
Olfactory receptor OR11-79
|
Homo
|
<M><E><L><W><N><F><T><L><G><S><G><F><I><L><V><G><I><L><N><D><S><G><S><P><E><L><L><C><A><T><I><T><I><L><Y><L><L><A><L><I><S><N><G><L><L><L><L><A><I><T><M><E><A><R><L><H><M><P><M><Y><L><L><L><G><Q><L><S><L><M><D><L><L><F><T><S><V><V><T><P><K><A><L><A><D><F><L><R><R><E><N><T><I><S><F><G><G><C><A><L><Q><M><F><L><A><L><T><M><G><G><A><E><D><L><L><L><A><F><M><A><Y><D><R><Y><V><A><I><C><H><P><L><T><Y><M><T><L><M><S><S><R><A><C><W><L><M><V><A><T><S><W><I><L><A><S><L><S><A><L><I><Y><T><V><Y><T><M><H><Y><P><F><C><R><A><Q><E><I><R><H><L><L><C><E><I><P><H><L><L><K><V><A><C><A><D><T><S><R><Y><E><L><M><V><Y><V><M><G><V><T><F><L><I><P><S><L><A><A><I><L><A><S><Y><T><Q><I><L><L><T><V><L><H><M><P><S><N><E><G><R><K><K><A><L><V><T><C><S><S><H><L><T><V><V><G><M><F><Y><G><A><A><T><F><M><Y><V><L><P><S><S><F><H><S><T><R><Q><D><N><I><I><S><V><F><Y><T><I><V><T><P><A><L><N><P><L><I><Y><S><L><R><N><K><E><V><M><R><A><L><R><R><V><L><G><K><Y><M><L><P><A><H><S><T><L>
|
Odorant receptor.<BOP>
|
Q9H205
|
P54868
|
HMCS2_HUMAN
|
3-hydroxy-3-methylglutaryl coenzyme A synthase
|
Homo
|
<M><Q><R><L><L><T><P><V><K><R><I><L><Q><L><T><R><A><V><Q><E><T><S><L><T><P><A><R><L><L><P><V><A><H><Q><R><F><S><T><A><S><A><V><P><L><A><K><T><D><T><W><P><K><D><V><G><I><L><A><L><E><V><Y><F><P><A><Q><Y><V><D><Q><T><D><L><E><K><Y><N><N><V><E><A><G><K><Y><T><V><G><L><G><Q><T><R><M><G><F><C><S><V><Q><E><D><I><N><S><L><C><L><T><V><V><Q><R><L><M><E><R><I><Q><L><P><W><D><S><V><G><R><L><E><V><G><T><E><T><I><I><D><K><S><K><A><V><K><T><V><L><M><E><L><F><Q><D><S><G><N><T><D><I><E><G><I><D><T><T><N><A><C><Y><G><G><T><A><S><L><F><N><A><A><N><W><M><E><S><S><S><W><D><G><R><Y><A><M><V><V><C><G><D><I><A><V><Y><P><S><G><N><A><R><P><T><G><G><A><G><A><V><A><M><L><I><G><P><K><A><P><L><A><L><E><R><G><L><R><G><T><H><M><E><N><V><Y><D><F><Y><K><P><N><L><A><S><E><Y><P><I><V><D><G><K><L><S><I><Q><C><Y><L><R><A><L><D><R><C><Y><T><S><Y><R><K><K><I><Q><N><Q><W><K><Q><A><G><S><D><R><P><F><T><L><D><D><L><Q><Y><M><I><F><H><T><P><F><C><K><M><V><Q><K><S><L><A><R><L><M><F><N><D><F><L><S><A><S><S><D><T><Q><T><S><L><Y><K><G><L><E><A><F><G><G><L><K><L><E><D><T><Y><T><N><K><D><L><D><K><A><L><L><K><A><S><Q><D><M><F><D><K><K><T><K><A><S><L><Y><L><S><T><H><N><G><N><M><Y><T><S><S><L><Y><G><C><L><A><S><L><L><S><H><H><S><A><Q><E><L><A><G><S><R><I><G><A><F><S><Y><G><S><G><L><A><A><S><F><F><S><F><R><V><S><Q><D><A><A><P><G><S><P><L><D><K><L><V><S><S><T><S><D><L><P><K><R><L><A><S><R><K><C><V><S><P><E><E><F><T><E><I><M><N><Q><R><E><Q><F><Y><H><K><V><N><F><S><P><P><G><D><T><N><S><L><F><P><G><T><W><Y><L><E><R><V><D><E><Q><H><R><R><K><Y><A><R><R><P><V>
|
Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.<BOP>
|
P54868
|
Q16775
|
GLO2_HUMAN
|
Glyoxalase II
|
Homo
|
<M><V><V><G><R><G><L><L><G><R><R><S><L><A><A><L><G><A><A><C><A><R><R><G><L><G><P><A><L><L><G><V><F><C><H><T><D><L><R><K><N><L><T><V><D><E><G><T><M><K><V><E><V><L><P><A><L><T><D><N><Y><M><Y><L><V><I><D><D><E><T><K><E><A><A><I><V><D><P><V><Q><P><Q><K><V><V><D><A><A><R><K><H><G><V><K><L><T><T><V><L><T><T><H><H><H><W><D><H><A><G><G><N><E><K><L><V><K><L><E><S><G><L><K><V><Y><G><G><D><D><R><I><G><A><L><T><H><K><I><T><H><L><S><T><L><Q><V><G><S><L><N><V><K><C><L><A><T><P><C><H><T><S><G><H><I><C><Y><F><V><S><K><P><G><G><S><E><P><P><A><V><F><T><G><D><T><L><F><V><A><G><C><G><K><F><Y><E><G><T><A><D><E><M><C><K><A><L><L><E><V><L><G><R><L><P><P><D><T><R><V><Y><C><G><H><E><Y><T><I><N><N><L><K><F><A><R><H><V><E><P><G><N><A><A><I><R><E><K><L><A><W><A><K><E><K><Y><S><I><G><E><P><T><V><P><S><T><L><A><E><E><F><T><Y><N><P><F><M><R><V><R><E><K><T><V><Q><Q><H><A><G><E><T><D><P><V><T><T><M><R><A><V><R><R><E><K><D><Q><F><K><M><P><R><D>
|
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.<BOP>
|
Q16775
|
Q6ZW76
|
ANKS3_HUMAN
|
Ankyrin repeat and SAM domain-containing protein 3
|
Homo
|
<M><S><E><L><S><D><E><A><S><E><P><E><L><L><N><R><S><L><S><M><W><H><G><L><G><T><Q><V><S><G><E><E><L><D><V><P><L><D><L><H><T><A><A><S><I><G><Q><Y><E><V><V><K><E><C><V><Q><R><R><E><L><D><L><N><K><K><N><G><G><G><W><T><P><L><M><Y><A><S><Y><I><G><H><D><T><I><V><H><L><L><L><E><A><G><V><S><V><N><V><P><T><P><E><G><Q><T><P><L><M><L><A><S><S><C><G><N><E><S><I><A><Y><F><L><L><Q><Q><G><A><E><L><E><M><K><D><I><Q><G><W><T><A><L><F><H><C><T><S><A><G><H><Q><H><M><V><R><F><L><L><D><S><G><A><N><A><N><V><R><E><P><I><C><G><F><T><P><L><M><E><A><A><A><A><G><H><E><I><I><V><Q><Y><F><L><N><H><G><V><K><V><D><A><R><D><H><S><G><A><T><A><R><M><L><A><K><Q><Y><G><H><M><K><I><V><A><L><M><D><T><Y><S><P><S><L><P><K><S><L><Y><R><S><P><E><K><Y><E><D><L><S><S><S><D><E><S><C><P><A><P><Q><R><Q><R><P><C><R><K><K><G><V><S><I><H><E><G><P><R><A><L><A><R><I><T><G><I><G><L><G><G><R><A><P><R><P><R><Y><E><Q><A><P><P><R><G><Y><V><T><F><N><S><S><G><E><N><P><L><E><E><E><G><L><C><C><R><D><V><T><S><P><I><N><E><R><D><V><E><S><S><S><S><S><S><S><R><E><E><H><A><F><C><A><N><L><G><P><V><Q><S><S><S><S><S><E><G><L><A><R><A><Q><G><L><S><S><E><A><S><V><E><S><N><E><D><S><D><H><A><C><K><S><S><A><R><K><Q><A><K><S><Y><M><K><T><K><N><P><D><S><Q><W><P><P><R><A><A><T><D><R><E><G><F><L><A><E><S><S><P><Q><T><Q><R><A><P><Y><S><G><P><Q><D><L><A><A><L><L><E><Q><I><G><C><L><K><Y><L><Q><V><F><E><E><Q><D><V><D><L><R><I><F><L><T><L><T><E><S><D><L><K><E><I><G><I><T><L><F><G><P><K><R><K><M><T><S><A><I><A><R><W><H><S><S><A><R><P><P><G><D><A><L><E><L><A><Y><A><D><R><L><E><A><E><M><Q><E><L><A><I><Q><L><H><K><R><C><E><E><V><E><A><T><R><G><Q><V><C><Q><E><Q><E><L><R><A><V><V><E><S><C><L><L><E><Q><D><R><A><R><E><D><L><Q><A><R><L><R><E><T><W><A><L><A><R><D><A><A><L><V><L><D><Q><L><R><A><C><Q><A><E><L><S><S><R><V><R><Q><D><Q><P><P><G><A><A><T><L><G><L><A><V><P><P><A><D><S><K><G><W><Q><A><S><L><Q><A><M><S><L><P><E><L><S><G><A><L><E><D><R><V><R><E><M><G><Q><A><L><C><L><V><T><Q><S><L><E><K><L><Q><V><L><N><G><K><K><W><R><E><T>
|
May be involved in vasopressin signaling in the kidney.<BOP>
|
Q6ZW76
|
Q8NH61
|
O51F2_HUMAN
|
Olfactory receptor OR11-23
|
Homo
|
<M><T><E><T><S><L><S><S><Q><C><F><P><M><S><V><L><N><N><T><I><A><E><P><L><I><F><L><L><M><G><I><P><G><L><K><A><T><Q><Y><W><I><S><I><P><F><C><L><L><Y><V><V><A><V><S><G><N><S><M><I><L><F><V><V><L><C><E><R><S><L><H><K><P><M><Y><Y><F><L><S><M><L><S><A><T><D><L><S><L><S><L><C><T><L><S><T><T><L><G><V><F><W><F><E><A><R><E><I><N><L><N><A><C><I><A><Q><M><F><F><L><H><G><F><T><F><M><E><S><G><V><L><L><A><M><A><F><D><R><F><V><A><I><C><Y><P><L><R><Y><T><T><I><L><T><N><A><R><I><A><K><I><G><M><S><M><L><I><R><N><V><A><V><M><L><P><V><M><L><F><V><K><R><L><S><F><C><S><S><M><V><L><S><H><S><Y><C><Y><H><V><D><L><I><Q><L><S><C><T><D><N><R><I><N><S><I><L><G><L><F><A><L><L><S><T><T><G><F><D><C><P><C><I><L><L><S><Y><I><L><I><I><R><S><V><L><S><I><A><S><S><E><E><R><R><K><A><F><N><T><C><T><S><H><I><S><A><V><S><I><F><Y><L><P><L><I><S><L><S><L><V><H><R><Y><G><H><S><A><P><P><F><V><H><I><I><M><A><N><V><F><L><L><I><P><P><V><L><N><P><I><I><Y><S><V><K><I><K><Q><I><Q><K><A><I><I><K><V><L><I><Q><K><H><S><K><S><N><H><Q><L><F><L><I><R><D><K><A><I><Y><E>
|
Odorant receptor.<BOP>
|
Q8NH61
|
Q5JXC2
|
MIIP_HUMAN
|
Invasion-inhibitory protein 45
|
Homo
|
<M><V><E><A><E><E><L><A><Q><L><R><L><L><N><L><E><L><L><R><Q><L><W><V><G><Q><D><A><V><R><R><S><V><A><R><A><A><S><E><S><S><L><E><S><S><S><S><Y><N><S><E><T><P><S><T><P><E><T><S><S><T><S><L><S><T><S><C><P><R><G><R><S><S><V><W><G><P><P><D><A><C><R><G><D><L><R><D><V><A><R><S><G><V><A><S><L><P><P><A><K><C><Q><H><Q><E><S><L><G><R><P><R><P><H><S><A><P><S><L><G><T><S><S><L><R><D><P><E><P><S><G><R><L><G><D><P><G><P><Q><E><A><Q><T><P><R><S><I><L><A><Q><Q><S><K><L><S><K><P><R><V><T><F><S><E><E><S><A><V><P><K><R><S><W><R><L><R><P><Y><L><G><Y><D><W><I><A><G><S><L><D><T><S><S><S><I><T><S><Q><P><E><A><F><F><S><K><L><Q><E><F><R><E><T><N><K><E><E><C><I><C><S><H><P><E><P><Q><L><P><G><L><R><E><S><S><G><S><G><V><E><E><D><H><E><C><V><Y><C><Y><R><V><N><R><R><L><F><P><V><P><V><D><P><G><T><P><C><R><L><C><R><T><P><R><D><Q><Q><G><P><G><T><L><A><Q><P><A><H><V><R><V><S><I><P><L><S><I><L><E><P><P><H><R><Y><H><I><H><R><R><K><S><F><D><A><S><D><T><L><A><L><P><R><H><C><L><L><G><W><D><I><F><P><P><K><S><E><K><S><S><A><P><R><N><L><D><L><W><S><S><V><S><A><E><A><Q><H><Q><K><L><S><G><T><S><S><P><F><H><P><A><S><P><M><Q><M><L><P><P><T><P><T><W><S><V><P><Q><V><P><R><P><H><V><P><R><Q><K><P>
|
Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.<BOP>
|
Q5JXC2
|
P36406
|
TRI23_HUMAN
|
Tripartite motif-containing protein 23
|
Homo
|
<M><A><T><L><V><V><N><K><L><G><A><G><V><D><S><G><R><Q><G><S><R><G><T><A><V><V><K><V><L><E><C><G><V><C><E><D><V><F><S><L><Q><G><D><K><V><P><R><L><L><L><C><G><H><T><V><C><H><D><C><L><T><R><L><P><L><H><G><R><A><I><R><C><P><F><D><R><Q><V><T><D><L><G><D><S><G><V><W><G><L><K><K><N><F><A><L><L><E><L><L><E><R><L><Q><N><G><P><I><G><Q><Y><G><A><A><E><E><S><I><G><I><S><G><E><S><I><I><R><C><D><E><D><E><A><H><L><A><S><V><Y><C><T><V><C><A><T><H><L><C><S><E><C><S><Q><V><T><H><S><T><K><T><L><A><K><H><R><R><V><P><L><A><D><K><P><H><E><K><T><M><C><S><Q><H><Q><V><H><A><I><E><F><V><C><L><E><E><G><C><Q><T><S><P><L><M><C><C><V><C><K><E><Y><G><K><H><Q><G><H><K><H><S><V><L><E><P><E><A><N><Q><I><R><A><S><I><L><D><M><A><H><C><I><R><T><F><T><E><E><I><S><D><Y><S><R><K><L><V><G><I><V><Q><H><I><E><G><G><E><Q><I><V><E><D><G><I><G><M><A><H><T><E><H><V><P><G><T><A><E><N><A><R><S><C><I><R><A><Y><F><Y><D><L><H><E><T><L><C><R><Q><E><E><M><A><L><S><V><V><D><A><H><V><R><E><K><L><I><W><L><R><Q><Q><Q><E><D><M><T><I><L><L><S><E><V><S><A><A><C><L><H><C><E><K><T><L><Q><Q><D><D><C><R><V><V><L><A><K><Q><E><I><T><R><L><L><E><T><L><Q><K><Q><Q><Q><Q><F><T><E><V><A><D><H><I><Q><L><D><A><S><I><P><V><T><F><T><K><D><N><R><V><H><I><G><P><K><M><E><I><R><V><V><T><L><G><L><D><G><A><G><K><T><T><I><L><F><K><L><K><Q><D><E><F><M><Q><P><I><P><T><I><G><F><N><V><E><T><V><E><Y><K><N><L><K><F><T><I><W><D><V><G><G><K><H><K><L><R><P><L><W><K><H><Y><Y><L><N><T><Q><A><V><V><F><V><V><D><S><S><H><R><D><R><I><S><E><A><H><S><E><L><A><K><L><L><T><E><K><E><L><R><D><A><L><L><L><I><F><A><N><K><Q><D><V><A><G><A><L><S><V><E><E><I><T><E><L><L><S><L><H><K><L><C><C><G><R><S><W><Y><I><Q><G><C><D><A><R><S><G><M><G><L><Y><E><G><L><D><W><L><S><R><Q><L><V><A><A><G><V><L><D><V><A>
|
(Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection.<BOP>
|
P36406
|
Q9ULZ1
|
APEL_HUMAN
|
Apelin-13
|
Homo
|
<M><N><L><R><L><C><V><Q><A><L><L><L><L><W><L><S><L><T><A><V><C><G><G><S><L><M><P><L><P><D><G><N><G><L><E><D><G><N><V><R><H><L><V><Q><P><R><G><S><R><N><G><P><G><P><W><Q><G><G><R><R><K><F><R><R><Q><R><P><R><L><S><H><K><G><P><M><P><F>
|
(Microbial infection) Endogenous ligand for the apelin receptor (APLNR), an alternative coreceptor with CD4 for HIV-1 infection . Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR . Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives .<BOP>
|
Q9ULZ1
|
O96013
|
PAK4_HUMAN
|
p21-activated kinase 4
|
Homo
|
<M><F><G><K><R><K><K><R><V><E><I><S><A><P><S><N><F><E><H><R><V><H><T><G><F><D><Q><H><E><Q><K><F><T><G><L><P><R><Q><W><Q><S><L><I><E><E><S><A><R><R><P><K><P><L><V><D><P><A><C><I><T><S><I><Q><P><G><A><P><K><T><I><V><R><G><S><K><G><A><K><D><G><A><L><T><L><L><L><D><E><F><E><N><M><S><V><T><R><S><N><S><L><R><R><D><S><P><P><P><P><A><R><A><R><Q><E><N><G><M><P><E><E><P><A><T><T><A><R><G><G><P><G><K><A><G><S><R><G><R><F><A><G><H><S><E><A><G><G><G><S><G><D><R><R><R><A><G><P><E><K><R><P><K><S><S><R><E><G><S><G><G><P><Q><E><S><S><R><D><K><R><P><L><S><G><P><D><V><G><T><P><Q><P><A><G><L><A><S><G><A><K><L><A><A><G><R><P><F><N><T><Y><P><R><A><D><T><D><H><P><S><R><G><A><Q><G><E><P><H><D><V><A><P><N><G><P><S><A><G><G><L><A><I><P><Q><S><S><S><S><S><S><R><P><P><T><R><A><R><G><A><P><S><P><G><V><L><G><P><H><A><S><E><P><Q><L><A><P><P><A><C><T><P><A><A><P><A><V><P><G><P><P><G><P><R><S><P><Q><R><E><P><Q><R><V><S><H><E><Q><F><R><A><A><L><Q><L><V><V><D><P><G><D><P><R><S><Y><L><D><N><F><I><K><I><G><E><G><S><T><G><I><V><C><I><A><T><V><R><S><S><G><K><L><V><A><V><K><K><M><D><L><R><K><Q><Q><R><R><E><L><L><F><N><E><V><V><I><M><R><D><Y><Q><H><E><N><V><V><E><M><Y><N><S><Y><L><V><G><D><E><L><W><V><V><M><E><F><L><E><G><G><A><L><T><D><I><V><T><H><T><R><M><N><E><E><Q><I><A><A><V><C><L><A><V><L><Q><A><L><S><V><L><H><A><Q><G><V><I><H><R><D><I><K><S><D><S><I><L><L><T><H><D><G><R><V><K><L><S><D><F><G><F><C><A><Q><V><S><K><E><V><P><R><R><K><S><L><V><G><T><P><Y><W><M><A><P><E><L><I><S><R><L><P><Y><G><P><E><V><D><I><W><S><L><G><I><M><V><I><E><M><V><D><G><E><P><P><Y><F><N><E><P><P><L><K><A><M><K><M><I><R><D><N><L><P><P><R><L><K><N><L><H><K><V><S><P><S><L><K><G><F><L><D><R><L><L><V><R><D><P><A><Q><R><A><T><A><A><E><L><L><K><H><P><F><L><A><K><A><G><P><P><A><S><I><V><P><L><M><R><Q><N><R><T><R>
|
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell
|
O96013
|
Q9BXB4
|
OSB11_HUMAN
|
Oxysterol-binding protein-related protein 11
|
Homo
|
<M><Q><G><G><E><P><V><S><T><M><K><V><S><E><S><E><G><K><L><E><G><Q><A><T><A><V><T><P><N><K><N><S><S><C><G><G><G><I><S><S><S><S><S><S><R><G><G><S><A><K><G><W><Q><Y><S><D><H><M><E><N><V><Y><G><Y><L><M><K><Y><T><N><L><V><T><G><W><Q><Y><R><F><F><V><L><N><N><E><A><G><L><L><E><Y><F><V><N><E><Q><S><R><N><Q><K><P><R><G><T><L><Q><L><A><G><A><V><I><S><P><S><D><E><D><S><H><T><F><T><V><N><A><A><S><G><E><Q><Y><K><L><R><A><T><D><A><K><E><R><Q><H><W><V><S><R><L><Q><I><C><T><Q><H><H><T><E><A><I><G><K><N><N><P><P><L><K><S><R><S><F><S><L><A><S><S><S><N><S><P><I><S><Q><R><R><P><S><Q><N><A><I><S><F><F><N><V><G><H><S><K><L><Q><S><L><S><K><R><T><N><L><P><P><D><H><L><V><E><V><R><E><M><M><S><H><A><E><G><Q><Q><R><D><L><I><R><R><I><E><C><L><P><T><S><G><H><L><S><S><L><D><Q><D><L><L><M><L><K><A><T><S><M><A><T><M><N><C><L><N><D><C><F><H><I><L><Q><L><Q><H><A><S><H><Q><K><G><S><L><P><S><G><T><T><I><E><W><L><E><P><K><I><S><L><S><N><H><Y><K><N><G><A><D><Q><P><F><A><T><D><Q><S><K><P><V><A><V><P><E><E><Q><P><V><A><E><S><G><L><L><A><R><E><P><E><E><I><N><A><D><D><E><I><E><D><T><C><D><H><K><E><D><D><L><G><A><V><E><E><Q><R><S><V><I><L><H><L><L><S><Q><L><K><L><G><M><D><L><T><R><V><V><L><P><T><F><I><L><E><K><R><S><L><L><E><M><Y><A><D><F><M><S><H><P><D><L><F><I><A><I><T><N><G><A><T><A><E><D><R><M><I><R><F><V><E><Y><Y><L><T><S><F><H><E><G><R><K><G><A><I><A><K><K><P><Y><N><P><I><I><G><E><T><F><H><C><S><W><K><M><P><K><S><E><V><A><S><S><V><F><S><S><S><S><T><Q><G><V><T><N><H><A><P><L><S><G><E><S><L><T><Q><V><G><S><D><C><Y><T><V><R><F><V><A><E><Q><V><S><H><H><P><P><V><S><G><F><Y><A><E><C><T><E><R><K><M><C><V><N><A><H><V><W><T><K><S><K><F><L><G><M><S><I><G><V><T><M><V><G><E><G><I><L><S><L><L><E><H><G><E><E><Y><T><F><S><L><P><C><A><Y><A><R><S><I><L><T><V><P><W><V><E><L><G><G><K><V><S><V><N><C><A><K><T><G><Y><S><A><S><I><T><F><H><T><K><P><F><Y><G><G><K><L><H><R><V><T><A><E><V><K><H><N><I><T><N><T><V><V><C><R><V><Q><G><E><W><N><S><V><L><E><F><T><Y><S><N><G><E><T><K><Y><V><D><L><T><K><L><A><V><T><K><K><R><V><R><P><L><E><K><Q><D><P><F><E><S><R><R><L><W><K><N><V><T><D><S><L><R><E><S><E><I><D><K><A><T><E><H><K><H><T><L><E><E><R><Q><R><T><E><E><R><H><R><T><E><T><G><T><P><W><K><T><K><Y><F><I><K><E><G><D><G><W><V><Y><H><K><P><L><W><K><I><I><P><T><T><Q><P><A><E>
|
Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage . Weakly binds 25-hydroxycholesterol .<BOP>
|
Q9BXB4
|
Q96ND0
|
F210A_HUMAN
|
Protein FAM210A
|
Homo
|
<M><Q><W><N><V><P><R><T><V><S><R><L><A><R><R><T><C><L><E><P><H><N><A><G><L><F><G><H><C><Q><N><V><K><G><P><L><L><L><Y><N><A><E><S><K><V><V><L><V><Q><G><P><Q><K><Q><W><L><H><L><S><A><A><Q><C><V><A><K><E><R><R><P><L><D><A><H><P><P><Q><P><G><V><L><R><H><K><Q><G><K><Q><H><V><S><F><R><R><V><F><S><S><S><A><T><A><Q><G><T><P><E><K><K><E><E><P><D><P><L><Q><D><K><S><I><S><L><Y><Q><R><F><K><K><T><F><R><Q><Y><G><K><V><L><I><P><V><H><L><I><T><S><G><V><W><F><G><T><F><Y><Y><A><A><L><K><G><V><N><V><V><P><F><L><E><L><I><G><L><P><D><S><V><V><S><I><L><K><N><S><Q><S><G><N><A><L><T><A><Y><A><L><F><K><I><A><T><P><A><R><Y><T><V><T><L><G><G><T><S><V><T><V><K><Y><L><R><S><H><G><Y><M><S><T><P><P><P><V><K><E><Y><L><Q><D><R><M><E><E><T><K><E><L><I><T><E><K><M><E><E><T><K><D><R><L><T><E><K><L><Q><E><T><K><E><K><V><S><F><K><K><K><V><E>
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May play a role in the structure and strength of both muscle and bone.<BOP>
|
Q96ND0
|
Q9Y2W2
|
WBP11_HUMAN
|
Splicing factor that interacts with PQBP-1 and PP1
|
Homo
|
<M><G><R><R><S><T><S><S><T><K><S><G><K><F><M><N><P><T><D><Q><A><R><K><E><A><R><K><R><E><L><K><K><N><K><K><Q><R><M><M><V><R><A><A><V><L><K><M><K><D><P><K><Q><I><I><R><D><M><E><K><L><D><E><M><E><F><N><P><V><Q><Q><P><Q><L><N><E><K><V><L><K><D><K><R><K><K><L><R><E><T><F><E><R><I><L><R><L><Y><E><K><E><N><P><D><I><Y><K><E><L><R><K><L><E><V><E><Y><E><Q><K><R><A><Q><L><S><Q><Y><F><D><A><V><K><N><A><Q><H><V><E><V><E><S><I><P><L><P><D><M><P><H><A><P><S><N><I><L><I><Q><D><I><P><L><P><G><A><Q><P><P><S><I><L><K><K><T><S><A><Y><G><P><P><T><R><A><V><S><I><L><P><L><L><G><H><G><V><P><R><L><P><P><G><R><K><P><P><G><P><P><P><G><P><P><P><P><Q><V><V><Q><M><Y><G><R><K><V><G><F><A><L><D><L><P><P><R><R><R><D><E><D><M><L><Y><S><P><E><L><A><Q><R><G><H><D><D><D><V><S><S><T><S><E><D><D><G><Y><P><E><D><M><D><Q><D><K><H><D><D><S><T><D><D><S><D><T><D><K><S><D><G><E><S><D><G><D><E><F><V><H><R><D><N><G><E><R><D><N><N><E><E><K><K><S><G><L><S><V><R><F><A><D><M><P><G><K><S><R><K><K><K><K><N><M><K><E><L><T><P><L><Q><A><M><M><L><R><M><A><G><Q><E><I><P><E><E><G><R><E><V><E><E><F><S><E><D><D><D><E><D><D><S><D><D><S><E><A><E><K><Q><S><Q><K><Q><H><K><E><E><S><H><S><D><G><T><S><T><A><S><S><Q><Q><Q><A><P><P><Q><S><V><P><P><S><Q><I><Q><A><P><P><M><P><G><P><P><P><L><G><P><P><P><A><P><P><L><R><P><P><G><P><P><T><G><L><P><P><G><P><P><P><G><A><P><P><F><L><R><P><P><G><M><P><G><L><R><G><P><L><P><R><L><L><P><P><G><P><P><P><G><R><P><P><G><P><P><P><G><P><P><P><G><L><P><P><G><P><P><P><R><G><P><P><P><R><L><P><P><P><A><P><P><G><I><P><P><P><R><P><G><M><M><R><P><P><L><V><P><P><L><G><P><A><P><P><G><L><F><P><P><A><P><L><P><N><P><G><V><L><S><A><P><P><N><L><I><Q><R><P><K><A><D><D><T><S><A><A><T><I><E><K><K><A><T><A><T><I><S><A><K><P><Q><I><T><N><P><K><A><E><I><T><R><F><V><P><T><A><L><R><V><R><R><E><N><K><G><A><T><A><A><P><Q><R><K><S><E><D><D><S><A><V><P><L><A><K><A><A><P><K><S><G><P><S><V><P><V><S><V><Q><T><K><D><D><V><Y><E><A><F><M><K><E><M><E><G><L><L>
|
Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity.<BOP>
|
Q9Y2W2
|
P31249
|
HXD3_HUMAN
|
Homeobox protein Hox-4A
|
Homo
|
<M><L><F><E><Q><G><Q><Q><A><L><E><L><P><E><C><T><M><Q><K><A><A><Y><Y><E><N><P><G><L><F><G><G><Y><G><Y><S><K><T><T><D><T><Y><G><Y><S><T><P><H><Q><P><Y><P><P><P><A><A><A><S><S><L><D><T><D><Y><P><G><S><A><C><S><I><Q><S><S><A><P><L><R><A><P><A><H><K><G><A><E><L><N><G><S><C><M><R><P><G><T><G><N><S><Q><G><G><G><G><G><S><Q><P><P><G><L><N><S><E><Q><Q><P><P><Q><P><P><P><P><P><P><T><L><P><P><S><S><P><T><N><P><G><G><G><V><P><A><K><K><P><K><G><G><P><N><A><S><S><S><S><A><T><I><S><K><Q><I><F><P><W><M><K><E><S><R><Q><N><S><K><Q><K><N><S><C><A><T><A><G><E><S><C><E><D><K><S><P><P><G><P><A><S><K><R><V><R><T><A><Y><T><S><A><Q><L><V><E><L><E><K><E><F><H><F><N><R><Y><L><C><R><P><R><R><V><E><M><A><N><L><L><N><L><T><E><R><Q><I><K><I><W><F><Q><N><R><R><M><K><Y><K><K><D><Q><K><A><K><G><I><L><H><S><P><A><S><Q><S><P><E><R><S><P><P><L><G><G><A><A><G><H><V><A><Y><S><G><Q><L><P><P><V><P><G><L><A><Y><D><A><P><S><P><P><A><F><A><K><S><Q><P><N><M><Y><G><L><A><A><Y><T><A><P><L><S><S><C><L><P><Q><Q><K><R><Y><A><A><P><E><F><E><P><H><P><M><A><S><N><G><G><G><F><A><S><A><N><L><Q><G><S><P><V><Y><V><G><G><N><F><V><E><S><M><A><P><A><S><G><P><V><F><N><L><G><H><L><S><H><P><S><S><A><S><V><D><Y><S><C><A><A><Q><I><P><G><N><H><H><H><G><P><C><D><P><H><P><T><Y><T><D><L><S><A><H><H><S><S><Q><G><R><L><P><E><A><P><K><L><T><H><L>
|
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP>
|
P31249
|
Q9C010
|
IPKB_HUMAN
|
cAMP-dependent protein kinase inhibitor beta
|
Homo
|
<M><R><T><D><S><S><K><M><T><D><V><E><S><G><V><A><N><F><A><S><S><A><R><A><G><R><R><N><A><L><P><D><I><Q><S><S><A><A><T><D><G><T><S><D><L><P><L><K><L><E><A><L><S><V><K><E><D><A><K><E><K><D><E><K><T><T><Q><D><Q><L><E><K><P><Q><N><E><E><K>
|
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.<BOP>
|
Q9C010
|
Q8NGT5
|
OR9A2_HUMAN
|
Olfactory receptor OR7-2
|
Homo
|
<M><M><D><N><H><S><S><A><T><E><F><H><L><L><G><F><P><G><S><Q><G><L><H><H><I><L><F><A><I><F><F><F><F><Y><L><V><T><L><M><G><N><T><V><I><I><V><I><V><C><V><D><K><R><L><Q><S><P><M><Y><F><F><L><S><H><L><S><T><L><E><I><L><V><T><T><I><I><V><P><M><M><L><W><G><L><L><F><L><G><C><R><Q><Y><L><S><L><H><V><S><L><N><F><S><C><G><T><M><E><F><A><L><L><G><V><M><A><V><D><R><Y><V><A><V><C><N><P><L><R><Y><N><I><I><M><N><S><S><T><C><I><W><V><V><I><V><S><W><V><F><G><F><L><S><E><I><W><P><I><Y><A><T><F><Q><F><T><F><R><K><S><N><S><L><D><H><F><Y><C><D><R><G><Q><L><L><K><L><S><C><D><N><T><L><L><T><E><F><I><L><F><L><M><A><V><F><I><L><I><G><S><L><I><P><T><I><V><S><Y><T><Y><I><I><S><T><I><L><K><I><P><S><A><S><G><R><R><K><A><F><S><T><F><A><S><H><F><T><C><V><V><I><G><Y><G><S><C><L><F><L><Y><V><K><P><K><Q><T><Q><G><V><E><Y><N><K><I><V><S><L><L><V><S><V><L><T><P><F><L><N><P><F><I><F><T><L><R><N><D><K><V><K><E><A><L><R><D><G><M><K><R><C><C><Q><L><L><K><D>
|
Odorant receptor.<BOP>
|
Q8NGT5
|
Q9UBT7
|
CTNL1_HUMAN
|
Catenin alpha-like protein 1
|
Homo
|
<M><A><A><S><P><G><P><A><G><V><G><G><A><G><A><V><Y><G><S><G><S><S><G><F><A><L><D><S><G><L><E><I><K><T><R><S><V><E><Q><T><L><L><P><L><V><S><Q><I><T><T><L><I><N><H><K><D><N><T><K><K><S><D><K><T><L><Q><A><I><Q><R><V><G><Q><A><V><N><L><A><V><G><R><F><V><K><V><G><E><A><I><A><N><E><N><W><D><L><K><E><E><I><N><I><A><C><I><E><A><K><Q><A><G><E><T><I><A><A><L><T><D><I><T><N><L><N><H><L><E><S><D><G><Q><I><T><I><F><T><D><K><T><G><V><I><K><A><A><R><L><L><L><S><S><V><T><K><V><L><L><L><A><D><R><V><V><I><K><Q><I><I><T><S><R><N><K><V><L><A><T><M><E><R><L><E><K><V><N><S><F><Q><E><F><V><Q><I><F><S><Q><F><G><N><E><M><V><E><F><A><H><L><S><G><D><R><Q><N><D><L><K><D><E><K><K><K><A><K><M><A><A><A><R><A><V><L><E><K><C><T><M><M><L><L><T><A><S><K><T><C><L><R><H><P><N><C><E><S><A><H><K><N><K><E><G><V><F><D><R><M><K><V><A><L><D><K><V><I><E><I><V><T><D><C><K><P><N><G><E><T><D><I><S><S><I><S><I><F><T><G><I><K><E><F><K><M><N><I><E><A><L><R><E><N><L><Y><F><Q><S><K><E><N><L><S><V><T><L><E><V><I><L><E><R><M><E><D><F><T><D><S><A><Y><T><S><H><E><H><R><E><R><I><L><E><L><S><T><Q><A><R><M><E><L><Q><Q><L><I><S><V><W><I><Q><A><Q><S><K><K><T><K><S><I><A><E><E><L><E><L><S><I><L><K><I><S><H><S><L><N><E><L><K><K><E><L><H><S><T><A><T><Q><L><A><A><D><L><L><K><Y><H><A><D><H><V><V><L><K><A><L><K><L><T><G><V><E><G><N><L><E><A><L><A><E><Y><A><C><K><L><S><E><Q><K><E><Q><L><V><E><T><C><R><L><L><R><H><I><S><G><T><E><P><L><E><I><T><C><I><H><A><E><E><T><F><Q><V><T><G><Q><Q><I><I><S><A><A><E><T><L><T><L><H><P><S><S><K><I><A><K><E><N><L><D><V><F><C><E><A><W><E><S><Q><I><S><D><M><S><T><L><L><R><E><I><N><D><V><F><E><G><R><R><G><E><K><Y><G><Y><L><S><L><P><K><P><M><K><N><N><A><N><L><K><S><L><K><P><D><K><P><D><S><E><E><Q><A><K><I><A><K><L><G><L><K><L><G><L><L><T><S><D><A><D><C><E><I><E><K><W><E><D><Q><E><N><E><I><V><Q><Y><G><R><N><M><S><S><M><A><Y><S><L><Y><L><F><T><R><G><E><G><P><L><K><T><S><Q><D><L><I><H><Q><L><E><V><F><A><A><E><G><L><K><L><T><S><S><V><Q><A><F><S><K><Q><L><K><D><D><D><K><L><M><L><L><L><E><I><N><K><L><I><P><L><C><H><Q><L><Q><T><V><T><K><T><S><L><Q><N><K><V><F><L><K><V><D><K><C><I><T><K><T><R><S><M><M><A><L><L><V><Q><L><L><S><L><C><Y><K><L><L><K><K><L><Q><M><E><N><N><G><W><V><S><V><T><N><K><D><T><M><D><S><K><T>
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May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).<BOP>
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Q9UBT7
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Q8NBP7
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PCSK9_HUMAN
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Subtilisin/kexin-like protease PC9
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Homo
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<M><G><T><V><S><S><R><R><S><W><W><P><L><P><L><L><L><L><L><L><L><L><L><G><P><A><G><A><R><A><Q><E><D><E><D><G><D><Y><E><E><L><V><L><A><L><R><S><E><E><D><G><L><A><E><A><P><E><H><G><T><T><A><T><F><H><R><C><A><K><D><P><W><R><L><P><G><T><Y><V><V><V><L><K><E><E><T><H><L><S><Q><S><E><R><T><A><R><R><L><Q><A><Q><A><A><R><R><G><Y><L><T><K><I><L><H><V><F><H><G><L><L><P><G><F><L><V><K><M><S><G><D><L><L><E><L><A><L><K><L><P><H><V><D><Y><I><E><E><D><S><S><V><F><A><Q><S><I><P><W><N><L><E><R><I><T><P><P><R><Y><R><A><D><E><Y><Q><P><P><D><G><G><S><L><V><E><V><Y><L><L><D><T><S><I><Q><S><D><H><R><E><I><E><G><R><V><M><V><T><D><F><E><N><V><P><E><E><D><G><T><R><F><H><R><Q><A><S><K><C><D><S><H><G><T><H><L><A><G><V><V><S><G><R><D><A><G><V><A><K><G><A><S><M><R><S><L><R><V><L><N><C><Q><G><K><G><T><V><S><G><T><L><I><G><L><E><F><I><R><K><S><Q><L><V><Q><P><V><G><P><L><V><V><L><L><P><L><A><G><G><Y><S><R><V><L><N><A><A><C><Q><R><L><A><R><A><G><V><V><L><V><T><A><A><G><N><F><R><D><D><A><C><L><Y><S><P><A><S><A><P><E><V><I><T><V><G><A><T><N><A><Q><D><Q><P><V><T><L><G><T><L><G><T><N><F><G><R><C><V><D><L><F><A><P><G><E><D><I><I><G><A><S><S><D><C><S><T><C><F><V><S><Q><S><G><T><S><Q><A><A><A><H><V><A><G><I><A><A><M><M><L><S><A><E><P><E><L><T><L><A><E><L><R><Q><R><L><I><H><F><S><A><K><D><V><I><N><E><A><W><F><P><E><D><Q><R><V><L><T><P><N><L><V><A><A><L><P><P><S><T><H><G><A><G><W><Q><L><F><C><R><T><V><W><S><A><H><S><G><P><T><R><M><A><T><A><V><A><R><C><A><P><D><E><E><L><L><S><C><S><S><F><S><R><S><G><K><R><R><G><E><R><M><E><A><Q><G><G><K><L><V><C><R><A><H><N><A><F><G><G><E><G><V><Y><A><I><A><R><C><C><L><L><P><Q><A><N><C><S><V><H><T><A><P><P><A><E><A><S><M><G><T><R><V><H><C><H><Q><Q><G><H><V><L><T><G><C><S><S><H><W><E><V><E><D><L><G><T><H><K><P><P><V><L><R><P><R><G><Q><P><N><Q><C><V><G><H><R><E><A><S><I><H><A><S><C><C><H><A><P><G><L><E><C><K><V><K><E><H><G><I><P><A><P><Q><E><Q><V><T><V><A><C><E><E><G><W><T><L><T><G><C><S><A><L><P><G><T><S><H><V><L><G><A><Y><A><V><D><N><T><C><V><V><R><S><R><D><V><S><T><T><G><S><T><S><E><G><A><V><T><A><V><A><I><C><C><R><S><R><H><L><A><Q><A><S><Q><E><L><Q>
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Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments . Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation . Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway . Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER
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Q8NBP7
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Q6P6B7
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ANR16_HUMAN
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Ankyrin repeat domain-containing protein 16
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Homo
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<M><A><Q><P><G><D><P><R><R><L><C><R><L><V><Q><E><G><R><L><R><A><L><K><E><E><L><Q><A><A><G><G><C><P><G><P><A><G><D><T><L><L><H><C><A><A><R><H><G><H><R><D><V><L><A><Y><L><A><E><A><W><G><M><D><I><E><A><T><N><R><D><Y><K><R><P><L><H><E><A><A><S><M><G><H><R><D><C><V><R><Y><L><L><G><R><G><A><A><V><D><C><L><K><K><A><D><W><T><P><L><M><M><A><C><T><R><K><N><L><G><V><I><Q><E><L><V><E><H><G><A><N><P><L><L><K><N><K><D><G><W><N><S><F><H><I><A><S><R><E><G><D><P><L><I><L><Q><Y><L><L><T><V><C><P><G><A><W><K><T><E><S><K><I><R><R><T><P><L><H><T><A><A><M><H><G><H><L><E><A><V><K><V><L><L><K><R><C><Q><Y><E><P><D><Y><R><D><N><C><G><V><T><A><L><M><D><A><I><Q><C><G><H><I><D><V><A><R><L><L><L><D><E><H><G><A><C><L><S><A><E><D><S><L><G><A><Q><A><L><H><R><A><A><V><T><G><Q><D><E><A><I><R><F><L><V><S><E><L><G><V><D><V><D><V><R><A><T><S><T><H><L><T><A><L><H><Y><A><A><K><E><G><H><T><S><T><I><Q><T><L><L><S><L><G><A><D><I><N><S><K><D><E><K><N><R><S><A><L><H><L><A><C><A><G><Q><H><L><A><C><A><K><F><L><L><Q><S><G><L><K><D><S><E><D><I><T><G><T><L><A><Q><Q><L><P><R><R><A><D><V><L><Q><G><S><G><H><S><A><M><T>
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Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides.<BOP>
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Q6P6B7
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Q969J3
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BORC5_HUMAN
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Myristoylated lysosomal protein
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Homo
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<M><G><S><E><Q><S><S><E><A><E><S><R><P><N><D><L><N><S><S><V><T><P><S><P><A><K><H><R><A><K><M><D><D><I><V><V><V><A><Q><G><S><Q><A><S><R><N><V><S><N><D><P><D><V><I><K><L><Q><E><I><P><T><F><Q><P><L><L><K><G><L><L><S><G><Q><T><S><P><T><N><A><K><L><E><K><L><D><S><Q><Q><V><L><Q><L><C><L><R><Y><Q><D><H><L><H><Q><C><A><E><A><V><A><F><D><Q><N><A><L><V><K><R><I><K><E><M><D><L><S><V><E><T><L><F><S><F><M><Q><E><R><Q><K><R><Y><A><K><Y><A><E><Q><I><Q><K><V><N><E><M><S><A><I><L><R><R><I><Q><M><G><I><D><Q><T><V><P><L><L><D><R><L><N><S><M><L><P><E><G><E><R><L><E><P><F><S><M><K><P><D><R><E><L><R><L>
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As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility.<BOP>
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Q969J3
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Q7Z5A4
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PRS42_HUMAN
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Testis serine protease 2
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Homo
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<M><S><S><G><G><G><S><R><G><L><L><A><W><L><L><L><L><Q><P><W><P><G><Q><N><W><A><G><M><A><A><P><R><L><P><S><P><L><L><S><E><E><G><G><E><N><P><E><A><S><P><A><P><G><P><E><A><G><P><P><L><N><L><F><T><S><F><P><G><D><S><L><L><C><G><R><T><P><L><R><I><V><G><G><V><D><A><E><E><G><R><W><P><W><Q><V><S><V><R><T><K><G><R><H><I><C><G><G><T><L><V><T><A><T><W><V><L><T><A><G><H><C><I><S><S><R><F><H><Y><S><V><K><M><G><D><R><S><V><Y><N><E><N><T><S><V><V><V><S><V><Q><R><A><F><V><H><P><K><F><S><T><V><T><T><I><R><N><D><L><A><L><L><Q><L><Q><H><P><V><N><F><T><S><N><I><Q><P><I><C><I><P><Q><E><N><F><Q><V><E><G><R><T><R><C><W><V><T><G><W><G><K><T><P><E><R><E><K><L><A><S><E><I><L><Q><D><V><D><Q><Y><I><M><C><Y><E><E><C><N><K><I><I><Q><K><A><L><S><S><T><K><D><V><I><I><K><G><M><V><C><G><Y><K><E><Q><G><K><D><S><C><Q><G><D><S><G><G><R><L><A><C><E><Y><N><D><T><W><V><Q><V><G><I><V><S><W><G><I><G><C><G><R>
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Plays a role in spermatogenesis. Involved in germ cell survival during meiosis.<BOP>
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Q7Z5A4
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Q9BRU9
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UTP23_HUMAN
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rRNA-processing protein UTP23 homolog
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Homo
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<M><K><I><T><R><Q><K><H><A><K><K><H><L><G><F><F><R><N><N><F><G><V><R><E><P><Y><Q><I><L><L><D><G><T><F><C><Q><A><A><L><R><G><R><I><Q><L><R><E><Q><L><P><R><Y><L><M><G><E><T><Q><L><C><T><T><R><C><V><L><K><E><L><E><T><L><G><K><D><L><Y><G><A><K><L><I><A><Q><K><C><Q><V><R><N><C><P><H><F><K><N><A><V><S><G><S><E><C><L><L><S><M><V><E><E><G><N><P><H><H><Y><F><V><A><T><Q><D><Q><N><L><S><V><K><V><K><K><K><P><G><V><P><L><M><F><I><I><Q><N><T><M><V><L><D><K><P><S><P><K><T><I><A><F><V><K><A><V><E><S><G><Q><L><V><S><V><H><E><K><E><S><I><K><H><L><K><E><E><Q><G><L><V><K><N><T><E><Q><S><R><R><K><K><R><K><K><I><S><G><P><N><P><L><S><C><L><K><K><K><K><K><A><P><D><T><Q><S><S><A><S><E><K><K><R><K><R><K><R><I><R><N><R><S><N><P><K><V><L><S><E><K><Q><N><A><E><G><E>
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Involved in rRNA-processing and ribosome biogenesis.<BOP>
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Q9BRU9
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Q9NWF4
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S52A1_HUMAN
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Riboflavin transporter 1
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Homo
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<M><A><A><P><T><L><G><R><L><V><L><T><H><L><L><V><A><L><F><G><M><G><S><W><A><A><V><N><G><I><W><V><E><L><P><V><V><V><K><D><L><P><E><G><W><S><L><P><S><Y><L><S><V><V><V><A><L><G><N><L><G><L><L><V><V><T><L><W><R><Q><L><A><P><G><K><G><E><Q><V><P><I><Q><V><V><Q><V><L><S><V><V><G><T><A><L><L><A><P><L><W><H><H><V><A><P><V><A><G><Q><L><H><S><V><A><F><L><T><L><A><L><V><L><A><M><A><C><C><T><S><N><V><T><F><L><P><F><L><S><H><L><P><P><P><F><L><R><S><F><F><L><G><Q><G><L><S><A><L><L><P><C><V><L><A><L><V><Q><G><V><G><R><L><E><C><P><P><A><P><T><N><G><T><S><G><P><P><L><D><F><P><E><R><F><P><A><S><T><F><F><W><A><L><T><A><L><L><V><T><S><A><A><A><F><R><G><L><L><L><L><L><P><S><L><P><S><V><T><T><G><G><S><G><P><E><L><Q><L><G><S><P><G><A><E><E><E><E><K><E><E><E><E><A><L><P><L><Q><E><P><P><S><Q><A><A><G><T><I><P><G><P><D><P><E><A><H><Q><L><F><S><A><H><G><A><F><L><L><G><L><M><A><F><T><S><A><V><T><N><G><V><L><P><S><V><Q><S><F><S><C><L><P><Y><G><R><L><A><Y><H><L><A><V><V><L><G><S><A><A><N><P><L><A><C><F><L><A><M><G><V><L><C><R><S><L><A><G><L><V><G><L><S><L><L><G><M><L><F><G><A><Y><L><M><A><L><A><I><L><S><P><C><P><P><L><V><G><T><T><A><G><V><V><L><V><V><L><S><W><V><L><C><L><C><V><F><S><Y><V><K><V><A><A><S><S><L><L><H><G><G><G><R><P><A><L><L><A><A><G><V><A><I><Q><V><G><S><L><L><G><A><G><A><M><F><P><P><T><S><I><Y><H><V><F><Q><S><R><K><D><C><V><D><P><C><G><P>
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(Microbial infection) May function as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).<BOP>
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Q9NWF4
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Q8TA94
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ZN563_HUMAN
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Zinc finger protein 563
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Homo
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<M><D><A><V><A><F><E><D><V><A><V><N><F><T><Q><E><E><W><A><L><L><G><P><S><Q><K><N><L><Y><R><Y><V><M><Q><E><T><I><R><N><L><D><C><I><R><M><I><W><E><E><Q><N><T><E><D><Q><Y><K><N><P><R><R><N><L><R><C><H><M><V><E><R><F><S><E><S><K><D><S><S><Q><C><G><E><T><F><S><L><I><R><D><S><I><V><N><N><S><I><C><P><G><E><D><P><C><Q><S><A><E><C><E><E><V><I><M><G><H><L><S><L><N><S><H><I><R><V><D><S><G><H><K><P><H><E><Y><Q><E><Y><G><E><K><P><H><T><H><K><Q><R><G><K><A><F><S><Y><H><H><S><F><Q><S><R><G><R><P><H><T><G><K><K><R><Y><E><C><K><E><C><G><K><T><F><S><S><R><R><N><L><R><R><H><M><V><V><Q><G><G><N><R><P><Y><K><C><K><L><C><G><K><A><F><F><W><P><S><L><L><R><M><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><S><K><A><F><P><F><Y><S><S><Y><R><R><H><E><R><M><H><T><G><E><K><P><Y><E><C><K><Q><C><S><K><A><L><P><D><S><S><S><Y><I><R><H><E><R><T><H><T><G><E><K><P><Y><T><C><K><Q><C><G><K><A><F><S><V><S><S><S><L><R><R><H><E><T><T><H><S><A><E><K><P><Y><E><C><K><Q><C><G><K><T><F><H><H><L><G><S><F><Q><I><H><M><K><R><H><T><G><D><R><P><H><K><C><K><I><C><G><K><G><F><D><R><P><S><L><V><R><Y><H><E><R><I><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><T><L><S><H><S><S><S><F><R><R><H><M><I><M><H><T><G><G><G><P><H><K><C><K><I><C><G><K><A><F><V><Y><P><S><V><C><Q><R><H><E><K><S><H><S><G><E><K><P><Y><E><C><K><Q><C><G><K><A><L><S><H><S><S><S><F><R><R><H><M><V><M><H><T><G><D><G><P><N><K><C><K><V><C><G><K><A><F><V><Y><P><S><V><C><Q><R><H><E><K><T><H><W><R><E><T><I>
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May be involved in transcriptional regulation.<BOP>
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Q8TA94
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Q9HCN2
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TPIP1_HUMAN
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p53-regulated apoptosis-inducing protein 1
|
Homo
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<M><G><S><S><S><E><A><S><F><R><S><A><Q><A><S><C><S><G><A><R><R><Q><G><L><G><R><G><D><Q><N><L><S><V><M><P><P><N><G><R><A><Q><T><H><T><P><G><W><V><S><D><P><L><V><L><G><A><Q><V><H><G><G><C><R><G><I><E><A><L><S><V><S><S><G><S><W><S><S><A><T><V><W><I><L><T><G><L><G><L><G><L><S><R><P><F><L><P><G><A><T><V><L><R><D><R><P><L><G><S><A><F><E><L><S><Y><D><Q><K><K><A><P><L><R><L><Q>
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May play an important role in mediating p53/TP53-dependent apoptosis.<BOP>
|
Q9HCN2
|
P14635
|
CCNB1_HUMAN
|
G2/mitotic-specific cyclin-B1
|
Homo
|
<M><A><L><R><V><T><R><N><S><K><I><N><A><E><N><K><A><K><I><N><M><A><G><A><K><R><V><P><T><A><P><A><A><T><S><K><P><G><L><R><P><R><T><A><L><G><D><I><G><N><K><V><S><E><Q><L><Q><A><K><M><P><M><K><K><E><A><K><P><S><A><T><G><K><V><I><D><K><K><L><P><K><P><L><E><K><V><P><M><L><V><P><V><P><V><S><E><P><V><P><E><P><E><P><E><P><E><P><E><P><V><K><E><E><K><L><S><P><E><P><I><L><V><D><T><A><S><P><S><P><M><E><T><S><G><C><A><P><A><E><E><D><L><C><Q><A><F><S><D><V><I><L><A><V><N><D><V><D><A><E><D><G><A><D><P><N><L><C><S><E><Y><V><K><D><I><Y><A><Y><L><R><Q><L><E><E><E><Q><A><V><R><P><K><Y><L><L><G><R><E><V><T><G><N><M><R><A><I><L><I><D><W><L><V><Q><V><Q><M><K><F><R><L><L><Q><E><T><M><Y><M><T><V><S><I><I><D><R><F><M><Q><N><N><C><V><P><K><K><M><L><Q><L><V><G><V><T><A><M><F><I><A><S><K><Y><E><E><M><Y><P><P><E><I><G><D><F><A><F><V><T><D><N><T><Y><T><K><H><Q><I><R><Q><M><E><M><K><I><L><R><A><L><N><F><G><L><G><R><P><L><P><L><H><F><L><R><R><A><S><K><I><G><E><V><D><V><E><Q><H><T><L><A><K><Y><L><M><E><L><T><M><L><D><Y><D><M><V><H><F><P><P><S><Q><I><A><A><G><A><F><C><L><A><L><K><I><L><D><N><G><E><W><T><P><T><L><Q><H><Y><L><S><Y><T><E><E><S><L><L><P><V><M><Q><H><L><A><K><N><V><V><M><V><N><Q><G><L><T><K><H><M><T><V><K><N><K><Y><A><T><S><K><H><A><K><I><S><T><L><P><Q><L><N><S><A><L><V><Q><D><L><A><K><A><V><A><K><V>
|
Essential for the control of the cell cycle at the G2/M (mitosis) transition.<BOP>
|
P14635
|
P06340
|
DOA_HUMAN
|
MHC class II antigen DOA
|
Homo
|
<M><A><L><R><A><G><L><V><L><G><F><H><T><L><M><T><L><L><S><P><Q><E><A><G><A><T><K><A><D><H><M><G><S><Y><G><P><A><F><Y><Q><S><Y><G><A><S><G><Q><F><T><H><E><F><D><E><E><Q><L><F><S><V><D><L><K><K><S><E><A><V><W><R><L><P><E><F><G><D><F><A><R><F><D><P><Q><G><G><L><A><G><I><A><A><I><K><A><H><L><D><I><L><V><E><R><S><N><R><S><R><A><I><N><V><P><P><R><V><T><V><L><P><K><S><R><V><E><L><G><Q><P><N><I><L><I><C><I><V><D><N><I><F><P><P><V><I><N><I><T><W><L><R><N><G><Q><T><V><T><E><G><V><A><Q><T><S><F><Y><S><Q><P><D><H><L><F><R><K><F><H><Y><L><P><F><V><P><S><A><E><D><V><Y><D><C><Q><V><E><H><W><G><L><D><A><P><L><L><R><H><W><E><L><Q><V><P><I><P><P><P><D><A><M><E><T><L><V><C><A><L><G><L><A><I><G><L><V><G><F><L><V><G><T><V><L><I><I><M><G><T><Y><V><S><S><V><P><R>
|
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.<BOP>
|
P06340
|
Q8TF47
|
ZFP90_HUMAN
|
Zinc finger protein 756
|
Homo
|
<M><A><P><R><P><P><T><A><A><P><Q><E><S><V><T><F><K><D><V><S><V><D><F><T><Q><E><E><W><Y><H><V><D><P><A><Q><R><S><L><Y><R><D><V><M><L><E><N><Y><S><H><L><V><S><L><G><Y><Q><V><S><K><P><E><V><I><F><K><L><E><Q><G><E><E><P><W><I><S><E><G><E><I><Q><R><P><F><Y><P><D><W><K><T><R><P><E><V><K><S><S><H><L><Q><Q><D><V><S><E><V><S><H><C><T><H><D><L><L><H><A><T><L><E><D><S><W><D><V><S><S><Q><L><D><R><Q><Q><E><N><W><K><R><H><L><G><S><E><A><S><T><Q><K><K><I><I><T><P><Q><E><N><F><E><Q><N><K><F><G><E><N><S><R><L><N><T><N><L><V><T><Q><L><N><I><P><A><R><I><R><P><S><E><C><E><T><L><G><S><N><L><G><H><N><A><D><L><L><N><E><N><N><I><L><A><K><K><K><P><Y><K><C><D><K><C><R><K><A><F><I><H><R><S><S><L><T><K><H><E><K><T><H><K><G><E><G><A><F><P><N><G><T><D><Q><G><I><Y><P><G><K><K><H><H><E><C><T><D><C><G><K><T><F><L><W><K><T><Q><L><T><E><H><Q><R><I><H><T><G><E><K><P><F><E><C><N><V><C><G><K><A><F><R><H><S><S><S><L><G><Q><H><E><N><A><H><T><G><E><K><P><Y><Q><C><S><L><C><G><K><A><F><Q><R><S><S><S><L><V><Q><H><Q><R><I><H><T><G><E><K><P><Y><R><C><N><L><C><G><R><S><F><R><H><G><T><S><L><T><Q><H><E><V><T><H><S><G><E><K><P><F><Q><C><K><E><C><G><K><A><F><S><R><C><S><S><L><V><Q><H><E><R><T><H><T><G><E><K><P><F><E><C><S><I><C><G><R><A><F><G><Q><S><P><S><L><Y><K><H><M><R><I><H><K><R><G><K><P><Y><Q><S><S><N><Y><S><I><D><F><K><H><S><T><S><L><T><Q><D><E><S><T><L><T><E><V><K><S><Y><H><C><N><D><C><G><E><D><F><S><H><I><T><D><F><T><D><H><Q><R><I><H><T><A><E><N><P><Y><D><C><E><Q><A><F><S><Q><Q><A><I><S><H><P><G><E><K><P><Y><Q><C><N><V><C><G><K><A><F><K><R><S><T><S><F><I><E><H><H><R><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><E><A><F><S><R><R><S><S><L><T><Q><H><E><R><T><H><T><G><E><K><P><Y><E><C><I><D><C><G><K><A><F><S><Q><S><S><S><L><I><Q><H><E><R><T><H><T><G><E><K><P><Y><E><C><N><E><C><G><R><A><F><R><K><K><T><N><L><H><D><H><Q><R><I><H><T><G><E><K><P><Y><S><C><K><E><C><G><K><N><F><S><R><S><S><A><L><T><K><H><Q><R><I><H><T><R><N><K><L>
|
Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg).<BOP>
|
Q8TF47
|
Q5FYB1
|
ARSI_HUMAN
|
Arylsulfatase I
|
Homo
|
<M><H><T><L><T><G><F><S><L><V><S><L><L><S><F><G><Y><L><S><W><D><W><A><K><P><S><F><V><A><D><G><P><G><E><A><G><E><Q><P><S><A><A><P><P><Q><P><P><H><I><I><F><I><L><T><D><D><Q><G><Y><H><D><V><G><Y><H><G><S><D><I><E><T><P><T><L><D><R><L><A><A><K><G><V><K><L><E><N><Y><Y><I><Q><P><I><C><T><P><S><R><S><Q><L><L><T><G><R><Y><Q><I><H><T><G><L><Q><H><S><I><I><R><P><Q><Q><P><N><C><L><P><L><D><Q><V><T><L><P><Q><K><L><Q><E><A><G><Y><S><T><H><M><V><G><K><W><H><L><G><F><Y><R><K><E><C><L><P><T><R><R><G><F><D><T><F><L><G><S><L><T><G><N><V><D><Y><Y><T><Y><D><N><C><D><G><P><G><V><C><G><F><D><L><H><E><G><E><N><V><A><W><G><L><S><G><Q><Y><S><T><M><L><Y><A><Q><R><A><S><H><I><L><A><S><H><S><P><Q><R><P><L><F><L><Y><V><A><F><Q><A><V><H><T><P><L><Q><S><P><R><E><Y><L><Y><R><Y><R><T><M><G><N><V><A><R><R><K><Y><A><A><M><V><T><C><M><D><E><A><V><R><N><I><T><W><A><L><K><R><Y><G><F><Y><N><N><S><V><I><I><F><S><S><D><N><G><G><Q><T><F><S><G><G><S><N><W><P><L><R><G><R><K><G><T><Y><W><E><G><G><V><R><G><L><G><F><V><H><S><P><L><L><K><R><K><Q><R><T><S><R><A><L><M><H><I><T><D><W><Y><P><T><L><V><G><L><A><G><G><T><T><S><A><A><D><G><L><D><G><Y><D><V><W><P><A><I><S><E><G><R><A><S><P><R><T><E><I><L><H><N><I><D><P><L><Y><N><H><A><Q><H><G><S><L><E><G><G><F><G><I><W><N><T><A><V><Q><A><A><I><R><V><G><E><W><K><L><L><T><G><D><P><G><Y><G><D><W><I><P><P><Q><T><L><A><T><F><P><G><S><W><W><N><L><E><R><M><A><S><V><R><Q><A><V><W><L><F><N><I><S><A><D><P><Y><E><R><E><D><L><A><G><Q><R><P><D><V><V><R><T><L><L><A><R><L><A><E><Y><N><R><T><A><I><P><V><R><Y><P><A><E><N><P><R><A><H><P><D><F><N><G><G><A><W><G><P><W><A><S><D><E><E><E><E><E><E><E><G><R><A><R><S><F><S><R><G><R><R><K><K><K><C><K><I><C><K><L><R><S><F><F><R><K><L><N><T><R><L><M><S><Q><R><I>
|
Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts . Lacks arylsulfatase activity .<BOP>
|
Q5FYB1
|
Q92560
|
BAP1_HUMAN
|
Cerebral protein 6
|
Homo
|
<M><N><K><G><W><L><E><L><E><S><D><P><G><L><F><T><L><L><V><E><D><F><G><V><K><G><V><Q><V><E><E><I><Y><D><L><Q><S><K><C><Q><G><P><V><Y><G><F><I><F><L><F><K><W><I><E><E><R><R><S><R><R><K><V><S><T><L><V><D><D><T><S><V><I><D><D><D><I><V><N><N><M><F><F><A><H><Q><L><I><P><N><S><C><A><T><H><A><L><L><S><V><L><L><N><C><S><S><V><D><L><G><P><T><L><S><R><M><K><D><F><T><K><G><F><S><P><E><S><K><G><Y><A><I><G><N><A><P><E><L><A><K><A><H><N><S><H><A><R><P><E><P><R><H><L><P><E><K><Q><N><G><L><S><A><V><R><T><M><E><A><F><H><F><V><S><Y><V><P><I><T><G><R><L><F><E><L><D><G><L><K><V><Y><P><I><D><H><G><P><W><G><E><D><E><E><W><T><D><K><A><R><R><V><I><M><E><R><I><G><L><A><T><A><G><E><P><Y><H><D><I><R><F><N><L><M><A><V><V><P><D><R><R><I><K><Y><E><A><R><L><H><V><L><K><V><N><R><Q><T><V><L><E><A><L><Q><Q><L><I><R><V><T><Q><P><E><L><I><Q><T><H><K><S><Q><E><S><Q><L><P><E><E><S><K><S><A><S><N><K><S><P><L><V><L><E><A><N><R><A><P><A><A><S><E><G><N><H><T><D><G><A><E><E><A><A><G><S><C><A><Q><A><P><S><H><S><P><P><N><K><P><K><L><V><V><K><P><P><G><S><S><L><N><G><V><H><P><N><P><T><P><I><V><Q><R><L><P><A><F><L><D><N><H><N><Y><A><K><S><P><M><Q><E><E><E><D><L><A><A><G><V><G><R><S><R><V><P><V><R><P><P><Q><Q><Y><S><D><D><E><D><D><Y><E><D><D><E><E><D><D><V><Q><N><T><N><S><A><L><R><Y><K><G><K><G><T><G><K><P><G><A><L><S><G><S><A><D><G><Q><L><S><V><L><Q><P><N><T><I><N><V><L><A><E><K><L><K><E><S><Q><K><D><L><S><I><P><L><S><I><K><T><S><S><G><A><G><S><P><A><V><A><V><P><T><H><S><Q><P><S><P><T><P><S><N><E><S><T><D><T><A><S><E><I><G><S><A><F><N><S><P><L><R><S><P><I><R><S><A><N><P><T><R><P><S><S><P><V><T><S><H><I><S><K><V><L><F><G><E><D><D><S><L><L><R><V><D><C><I><R><Y><N><R><A><V><R><D><L><G><P><V><I><S><T><G><L><L><H><L><A><E><D><G><V><L><S><P><L><A><L><T><E><G><G><K><G><S><S><P><S><I><R><P><I><Q><G><S><Q><G><S><S><S><P><V><E><K><E><V><V><E><A><T><D><S><R><E><K><T><G><M><V><R><P><G><E><P><L><S><G><E><K><Y><S><P><K><E><L><L><A><L><L><K><C><V><E><A><E><I><A><N><Y><E><A><C><L><K><E><E><V><E><K><R><K><K><F><K><I><D><D><Q><R><R><T><H><N><Y><D><E><F><I><C><T><F><I><S><M><L><A><Q><E><G><M><L><A><N><L><V><E><Q><N><I><S><V><R><R><R><Q><G><V><S><I><G><R><L><H><K><Q><R><K><P><D><R><R><K><R><S><R><P><Y><K><A><K><R><Q>
|
Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 . Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) . Does not deubiquitinate monoubiquitinated histone H2B . Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains . Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 . Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination . It however does not mediate deubiquitination of BRCA1 and BARD1 . Able to mediate autodeubiquitination via intramolecular interactions to couteract mon
|
Q92560
|
Q13490
|
BIRC2_HUMAN
|
TNFR2-TRAF-signaling complex protein 2
|
Homo
|
<M><H><K><T><A><S><Q><R><L><F><P><G><P><S><Y><Q><N><I><K><S><I><M><E><D><S><T><I><L><S><D><W><T><N><S><N><K><Q><K><M><K><Y><D><F><S><C><E><L><Y><R><M><S><T><Y><S><T><F><P><A><G><V><P><V><S><E><R><S><L><A><R><A><G><F><Y><Y><T><G><V><N><D><K><V><K><C><F><C><C><G><L><M><L><D><N><W><K><L><G><D><S><P><I><Q><K><H><K><Q><L><Y><P><S><C><S><F><I><Q><N><L><V><S><A><S><L><G><S><T><S><K><N><T><S><P><M><R><N><S><F><A><H><S><L><S><P><T><L><E><H><S><S><L><F><S><G><S><Y><S><S><L><S><P><N><P><L><N><S><R><A><V><E><D><I><S><S><S><R><T><N><P><Y><S><Y><A><M><S><T><E><E><A><R><F><L><T><Y><H><M><W><P><L><T><F><L><S><P><S><E><L><A><R><A><G><F><Y><Y><I><G><P><G><D><R><V><A><C><F><A><C><G><G><K><L><S><N><W><E><P><K><D><D><A><M><S><E><H><R><R><H><F><P><N><C><P><F><L><E><N><S><L><E><T><L><R><F><S><I><S><N><L><S><M><Q><T><H><A><A><R><M><R><T><F><M><Y><W><P><S><S><V><P><V><Q><P><E><Q><L><A><S><A><G><F><Y><Y><V><G><R><N><D><D><V><K><C><F><C><C><D><G><G><L><R><C><W><E><S><G><D><D><P><W><V><E><H><A><K><W><F><P><R><C><E><F><L><I><R><M><K><G><Q><E><F><V><D><E><I><Q><G><R><Y><P><H><L><L><E><Q><L><L><S><T><S><D><T><T><G><E><E><N><A><D><P><P><I><I><H><F><G><P><G><E><S><S><S><E><D><A><V><M><M><N><T><P><V><V><K><S><A><L><E><M><G><F><N><R><D><L><V><K><Q><T><V><Q><S><K><I><L><T><T><G><E><N><Y><K><T><V><N><D><I><V><S><A><L><L><N><A><E><D><E><K><R><E><E><E><K><E><K><Q><A><E><E><M><A><S><D><D><L><S><L><I><R><K><N><R><M><A><L><F><Q><Q><L><T><C><V><L><P><I><L><D><N><L><L><K><A><N><V><I><N><K><Q><E><H><D><I><I><K><Q><K><T><Q><I><P><L><Q><A><R><E><L><I><D><T><I><L><V><K><G><N><A><A><A><N><I><F><K><N><C><L><K><E><I><D><S><T><L><Y><K><N><L><F><V><D><K><N><M><K><Y><I><P><T><E><D><V><S><G><L><S><L><E><E><Q><L><R><R><L><Q><E><E><R><T><C><K><V><C><M><D><K><E><V><S><V><V><F><I><P><C><G><H><L><V><V><C><Q><E><C><A><P><S><L><R><K><C><P><I><C><R><G><I><I><K><G><T><V><R><T><F><L><S>
|
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs)
|
Q13490
|
Q6PF06
|
TM10B_HUMAN
|
tRNA (guanine(9)-N(1))-methyltransferase TRMT10B
|
Homo
|
<M><D><W><K><L><E><G><S><T><Q><K><V><E><S><P><V><L><Q><G><Q><E><G><I><L><E><E><T><G><E><D><G><L><P><E><G><F><Q><L><L><Q><I><D><A><E><G><E><C><Q><E><G><E><I><L><A><T><G><S><T><A><W><C><S><K><N><V><Q><R><K><Q><R><H><W><E><K><I><V><A><A><K><K><S><K><R><K><Q><E><K><E><R><R><K><A><N><R><A><E><N><P><G><I><C><P><Q><H><S><K><R><F><L><R><A><L><T><K><D><K><L><L><E><A><K><H><S><G><P><R><L><C><I><D><L><S><M><T><H><Y><M><S><K><K><E><L><S><R><L><A><G><Q><I><R><R><L><Y><G><S><N><K><K><A><D><R><P><F><W><I><C><L><T><G><F><T><T><D><S><P><L><Y><E><E><C><V><R><M><N><D><G><F><S><S><Y><L><L><D><I><T><E><E><D><C><F><S><L><F><P><L><E><T><L><V><Y><L><T><P><D><S><E><H><A><L><E><D><V><D><L><N><K><V><Y><I><L><G><G><L><V><D><E><S><I><Q><K><K><V><T><F><Q><K><A><R><E><Y><S><V><K><T><A><R><L><P><I><Q><E><Y><M><V><R><N><Q><N><G><K><N><Y><H><S><E><I><L><A><I><N><Q><V><F><D><I><L><S><T><Y><L><E><T><H><N><W><P><E><A><L><K><K><G><V><S><S><G><K><G><Y><I><L><R><N><S><V><E>
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S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs . Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs .<BOP>
|
Q6PF06
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Q8NH79
|
OR6X1_HUMAN
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Olfactory receptor OR11-270
|
Homo
|
<M><R><N><G><T><V><I><T><E><F><I><L><L><G><F><P><V><I><Q><G><L><Q><T><P><L><F><I><A><I><F><L><T><Y><I><L><T><L><A><G><N><G><L><I><I><A><T><V><W><A><E><P><R><L><Q><I><P><M><Y><F><F><L><C><N><L><S><F><L><E><I><W><Y><T><T><T><V><I><P><K><L><L><G><T><F><V><V><A><R><T><V><I><C><M><S><C><C><L><L><Q><A><F><F><H><F><F><V><G><T><T><E><F><L><I><L><T><I><M><S><F><D><R><Y><L><T><I><C><N><P><L><H><H><P><T><I><M><T><S><K><L><C><L><Q><L><A><L><S><S><W><V><V><G><F><T><I><V><F><C><Q><T><M><L><L><I><Q><L><P><F><C><G><N><N><V><I><S><H><F><Y><C><D><V><G><P><S><L><K><A><A><C><I><D><T><S><I><L><E><L><L><G><V><I><A><T><I><L><V><I><P><G><S><L><L><F><N><M><I><S><Y><I><Y><I><L><S><A><I><L><R><I><P><S><A><T><G><H><Q><K><T><F><S><T><C><A><S><H><L><T><V><V><S><L><L><Y><G><A><V><L><F><M><Y><L><R><P><T><A><H><S><S><F><K><I><N><K><V><V><S><V><L><N><T><I><L><T><P><L><L><N><P><F><I><Y><T><I><R><N><K><E><V><K><G><A><L><R><K><A><M><T><C><P><K><T><G><H><A><K>
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Odorant receptor.<BOP>
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Q8NH79
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A0A087WSX0
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LV545_HUMAN
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Immunoglobulin lambda variable 5-45
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Homo
|
<M><A><W><T><P><L><L><L><L><F><L><S><H><C><T><G><S><L><S><Q><A><V><L><T><Q><P><S><S><L><S><A><S><P><G><A><S><A><S><L><T><C><T><L><C><S><G><I><N><V><G><T><Y><R><I><Y><W><Y><Q><Q><K><P><G><S><P><P><Q><Y><L><L><R><Y><K><S><D><S><D><K><Q><Q><G><S><G><V><P><S><R><F><S><G><S><K><D><A><S><A><N><A><G><I><L><L><I><S><G><L><Q><S><E><D><E><A><D><Y><Y><C><M><I><W><H><S><S><A><S>
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V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
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A0A087WSX0
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P22415
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USF1_HUMAN
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Major late transcription factor 1
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Homo
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<M><K><G><Q><Q><K><T><A><E><T><E><E><G><T><V><Q><I><Q><E><G><A><V><A><T><G><E><D><P><T><S><V><A><I><A><S><I><Q><S><A><A><T><F><P><D><P><N><V><K><Y><V><F><R><T><E><N><G><G><Q><V><M><Y><R><V><I><Q><V><S><E><G><Q><L><D><G><Q><T><E><G><T><G><A><I><S><G><Y><P><A><T><Q><S><M><T><Q><A><V><I><Q><G><A><F><T><S><D><D><A><V><D><T><E><G><T><A><A><E><T><H><Y><T><Y><F><P><S><T><A><V><G><D><G><A><G><G><T><T><S><G><S><T><A><A><V><V><T><T><Q><G><S><E><A><L><L><G><Q><A><T><P><P><G><T><G><Q><F><F><V><M><M><S><P><Q><E><V><L><Q><G><G><S><Q><R><S><I><A><P><R><T><H><P><Y><S><P><K><S><E><A><P><R><T><T><R><D><E><K><R><R><A><Q><H><N><E><V><E><R><R><R><R><D><K><I><N><N><W><I><V><Q><L><S><K><I><I><P><D><C><S><M><E><S><T><K><S><G><Q><S><K><G><G><I><L><S><K><A><C><D><Y><I><Q><E><L><R><Q><S><N><H><R><L><S><E><E><L><Q><G><L><D><Q><L><Q><L><D><N><D><V><L><R><Q><Q><V><E><D><L><K><N><K><N><L><L><L><R><A><Q><L><R><H><H><G><L><E><V><V><I><K><N><D><S><N>
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Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.<BOP>
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P22415
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Q9NZI5
|
GRHL1_HUMAN
|
Transcription factor LBP-32
|
Homo
|
<M><T><Q><E><Y><D><N><K><R><P><V><L><V><L><Q><N><E><A><L><Y><P><Q><R><R><S><Y><T><S><E><D><E><A><W><K><S><F><L><E><N><P><L><T><A><A><T><K><A><M><M><S><I><N><G><D><E><D><S><A><A><A><L><G><L><L><Y><D><Y><Y><K><V><P><R><E><R><R><S><S><T><A><K><P><E><V><E><H><P><E><P><D><H><S><K><R><N><S><I><P><I><V><T><E><Q><P><L><I><S><A><G><E><N><R><V><Q><V><L><K><N><V><P><F><N><I><V><L><P><H><G><N><Q><L><G><I><D><K><R><G><H><L><T><A><P><D><T><T><V><T><V><S><I><A><T><M><P><T><H><S><I><K><T><E><T><Q><P><H><G><F><A><V><G><I><P><P><A><V><Y><H><P><E><P><T><E><R><V><V><V><F><D><R><N><L><N><T><D><Q><F><S><S><G><A><Q><A><P><N><A><Q><R><R><T><P><D><S><T><F><S><E><T><F><K><E><G><V><Q><E><V><F><F><P><S><D><L><S><L><R><M><P><G><M><N><S><E><D><Y><V><F><D><S><V><S><G><N><N><F><E><Y><T><L><E><A><S><K><S><L><R><Q><K><P><G><D><S><T><M><T><Y><L><N><K><G><Q><F><Y><P><I><T><L><K><E><V><S><S><S><E><G><I><H><H><P><I><S><K><V><R><S><V><I><M><V><V><F><A><E><D><K><S><R><E><D><Q><L><R><H><W><K><Y><W><H><S><R><Q><H><T><A><K><Q><R><C><I><D><I><A><D><Y><K><E><S><F><N><T><I><S><N><I><E><E><I><A><Y><N><A><I><S><F><T><W><D><I><N><D><E><A><K><V><F><I><S><V><N><C><L><S><T><D><F><S><S><Q><K><G><V><K><G><L><P><L><N><I><Q><V><D><T><Y><S><Y><N><N><R><S><N><K><P><V><H><R><A><Y><C><Q><I><K><V><F><C><D><K><G><A><E><R><K><I><R><D><E><E><R><K><Q><S><K><R><K><V><S><D><V><K><V><P><L><L><P><S><H><K><R><M><D><I><T><V><F><K><P><F><I><D><L><D><T><Q><P><V><L><F><I><P><D><V><H><F><A><N><L><Q><R><G><T><H><V><L><P><I><A><S><E><E><L><E><G><E><G><S><V><L><K><R><G><P><Y><G><T><E><D><D><F><A><V><P><P><S><T><K><L><A><R><I><E><E><P><K><R><V><L><L><Y><V><R><K><E><S><E><E><V><F><D><A><L><M><L><K><T><P><S><L><K><G><L><M><E><A><I><S><D><K><Y><D><V><P><H><D><K><I><G><K><I><F><K><K><C><K><K><G><I><L><V><N><M><D><D><N><I><V><K><H><Y><S><N><E><D><T><F><Q><L><Q><I><E><E><A><G><G><S><Y><K><L><T><L><T><E><I>
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May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed.<BOP>
|
Q9NZI5
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Q9HB96
|
FANCE_HUMAN
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Fanconi anemia group E protein
|
Homo
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<M><A><T><P><D><A><G><L><P><G><A><E><G><V><E><P><A><P><W><A><Q><L><E><A><P><A><R><L><L><L><Q><A><L><Q><A><G><P><E><G><A><R><R><G><L><G><V><L><R><A><L><G><S><R><G><W><E><P><F><D><W><G><R><L><L><E><A><L><C><R><E><E><P><V><V><Q><G><P><D><G><R><L><E><L><K><P><L><L><L><R><L><P><R><I><C><Q><R><N><L><M><S><L><L><M><A><V><R><P><S><L><P><E><S><G><L><L><S><V><L><Q><I><A><Q><Q><D><L><A><P><D><P><D><A><W><L><R><A><L><G><E><L><L><R><R><D><L><G><V><G><T><S><M><E><G><A><S><P><L><S><E><R><C><Q><R><Q><L><Q><S><L><C><R><G><L><G><L><G><G><R><R><L><K><S><P><Q><A><P><D><P><E><E><E><E><N><R><D><S><Q><Q><P><G><K><R><R><K><D><S><E><E><E><A><A><S><P><E><G><K><R><V><P><K><R><L><R><C><W><E><E><E><E><D><H><E><K><E><R><P><E><H><K><S><L><E><S><L><A><D><G><G><S><A><S><P><I><K><D><Q><P><V><M><A><V><K><T><G><E><D><G><S><N><L><D><D><A><K><G><L><A><E><S><L><E><L><P><K><A><I><Q><D><Q><L><P><R><L><Q><Q><L><L><K><T><L><E><E><G><L><E><G><L><E><D><A><P><P><V><E><L><Q><L><L><H><E><C><S><P><S><Q><M><D><L><L><C><A><Q><L><Q><L><P><Q><L><S><D><L><G><L><L><R><L><C><T><W><L><L><A><L><S><P><D><L><S><L><S><N><A><T><V><L><T><R><S><L><F><L><G><R><I><L><S><L><T><S><S><A><S><R><L><L><T><T><A><L><T><S><F><C><A><K><Y><T><Y><P><V><C><S><A><L><L><D><P><V><L><Q><A><P><G><T><G><P><A><Q><T><E><L><L><C><C><L><V><K><M><E><S><L><E><P><D><A><Q><V><L><M><L><G><Q><I><L><E><L><P><W><K><E><E><T><F><L><V><L><Q><S><L><L><E><R><Q><V><E><M><T><P><E><K><F><S><V><L><M><E><K><L><C><K><K><G><L><A><A><T><T><S><M><A><Y><A><K><L><M><L><T><V><M><T><K><Y><Q><A><N><I><T><E><T><Q><R><L><G><L><A><M><A><L><E><P><N><T><T><F><L><R><K><S><L><K><A><A><L><K><H><L><G><P>
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As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2.<BOP>
|
Q9HB96
|
Q9Y2G2
|
CARD8_HUMAN
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Caspase recruitment domain-containing protein 8, N-terminus
|
Homo
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<M><E><K><K><E><C><P><E><K><S><S><S><S><E><E><E><L><P><R><R><D><S><G><S><S><R><N><I><D><A><S><K><L><I><R><L><Q><G><S><R><K><L><L><V><D><N><S><I><R><E><L><Q><Y><T><K><T><G><I><F><F><Q><A><E><A><C><V><T><N><D><T><V><Y><R><E><L><P><C><V><S><E><T><L><C><D><I><S><H><F><F><Q><E><D><D><E><T><E><A><E><P><L><L><F><R><A><V><P><E><C><Q><L><S><G><G><D><I><P><S><V><S><E><E><Q><E><S><S><E><G><Q><D><S><G><D><I><C><S><E><E><N><Q><I><V><S><S><Y><A><S><K><V><C><F><E><I><E><E><D><Y><K><N><R><Q><F><L><G><P><E><G><N><V><D><V><E><L><I><D><K><S><T><N><R><Y><S><V><W><F><P><T><A><G><W><Y><L><W><S><A><T><G><L><G><F><L><V><R><D><E><V><T><V><T><I><A><F><G><S><W><S><Q><H><L><A><L><D><L><Q><H><H><E><Q><W><L><V><G><G><P><L><F><D><V><T><A><E><P><E><E><A><V><A><E><I><H><L><P><H><F><I><S><L><Q><A><G><E><V><D><V><S><W><F><L><V><A><H><F><K><N><E><G><M><V><L><E><H><P><A><R><V><E><P><F><Y><A><V><L><E><S><P><S><F><S><L><M><G><I><L><L><R><I><A><S><G><T><R><L><S><I><P><I><T><S><N><T><L><I><Y><Y><H><P><H><P><E><D><I><K><F><H><L><Y><L><V><P><S><D><A><L><L><T><K><A><I><D><D><E><E><D><R><F><H><G><V><R><L><Q><T><S><P><P><M><E><P><L><N><F><G><S><S><Y><I><V><S><N><S><A><N><L><K><V><M><P><K><E><L><K><L><S><Y><R><S><P><G><E><I><Q><H><F><S><K><F><Y><A><G><Q><M><K><E><P><I><Q><L><E><I><T><E><K><R><H><G><T><L><V><W><D><T><E><V><K><P><V><D><L><Q><L><V><A><A><S><A><P><P><P><F><S><G><A><A><F><V><K><E><N><H><R><Q><L><Q><A><R><M><G><D><L><K><G><V><L><D><D><L><Q><D><N><E><V><L><T><E><N><E><K><E><L><V><E><Q><E><K><T><R><Q><S><K><N><E><A><L><L><S><M><V><E><K><K><G><D><L><A><L><D><V><L><F><R><S><I><S><E><R><D><P><Y><L><V><S><Y><L><R><Q><Q><N><L>
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Constitutes the active part of the CARD8 inflammasome . In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of CARD8 (Caspase recruitment domain-containing protein 8, N-terminus), preventing activation of the CARD8 inflammasome . In response to pathogen-associated signals, the N-terminal part of CARD8 is degraded by the proteasome, releasing this form, which polymerizes to form the CARD8 inflammasome complex: the CARD8 inflammasome complex then directly recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, leading to gasdermin-D (GSDMD) cleavage and subsequent pyroptosis .<BOP>
|
Q9Y2G2
|
Q9BRJ7
|
TIRR_HUMAN
|
Protein syndesmos
|
Homo
|
<M><S><T><A><A><V><P><E><L><K><Q><I><S><R><V><E><A><M><R><L><G><P><G><W><S><H><S><C><H><A><M><L><Y><A><A><N><P><G><Q><L><F><G><R><I><P><M><R><F><S><V><L><M><Q><M><R><F><D><G><L><L><G><F><P><G><G><F><V><D><R><R><F><W><S><L><E><D><G><L><N><R><V><L><G><L><G><L><G><C><L><R><L><T><E><A><D><Y><L><S><S><H><L><T><E><G><P><H><R><V><V><A><H><L><Y><A><R><Q><L><T><L><E><Q><L><H><A><V><E><I><S><A><V><H><S><R><D><H><G><L><E><V><L><G><L><V><R><V><P><L><Y><T><Q><K><D><R><V><G><G><F><P><N><F><L><S><N><A><F><V><S><T><A><K><C><Q><L><L><F><A><L><K><V><L><N><M><M><P><E><E><K><L><V><E><A><L><A><A><A><T><E><K><Q><K><K><A><L><E><K><L><L><P><A><S><S>
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Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin . In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus . Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) . Binds U8 snoRNA .<BOP>
|
Q9BRJ7
|
Q9Y2Y0
|
AR2BP_HUMAN
|
Binder of ARF2 protein 1
|
Homo
|
<M><D><A><L><E><G><E><S><F><A><L><S><F><S><S><A><S><D><A><E><F><D><A><V><V><G><Y><L><E><D><I><I><M><D><D><E><F><Q><L><L><Q><R><N><F><M><D><K><Y><Y><L><E><F><E><D><T><E><E><N><K><L><I><Y><T><P><I><F><N><E><Y><I><S><L><V><E><K><Y><I><E><E><Q><L><L><Q><R><I><P><E><F><N><M><A><A><F><T><T><T><L><Q><H><H><K><D><E><V><A><G><D><I><F><D><M><L><L><T><F><T><D><F><L><A><F><K><E><M><F><L><D><Y><R><A><E><K><E><G><R><G><L><D><L><S><S><G><L><V><V><T><S><L><C><K><S><S><S><L><P><A><S><Q><N><N><L><R><H>
|
Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.<BOP>
|
Q9Y2Y0
|
P52272
|
HNRPM_HUMAN
|
Heterogeneous nuclear ribonucleoprotein M
|
Homo
|
<M><A><A><G><V><E><A><A><A><E><V><A><A><T><E><I><K><M><E><E><E><S><G><A><P><G><V><P><S><G><N><G><A><P><G><P><K><G><E><G><E><R><P><A><Q><N><E><K><R><K><E><K><N><I><K><R><G><G><N><R><F><E><P><Y><A><N><P><T><K><R><Y><R><A><F><I><T><N><I><P><F><D><V><K><W><Q><S><L><K><D><L><V><K><E><K><V><G><E><V><T><Y><V><E><L><L><M><D><A><E><G><K><S><R><G><C><A><V><V><E><F><K><M><E><E><S><M><K><K><A><A><E><V><L><N><K><H><S><L><S><G><R><P><L><K><V><K><E><D><P><D><G><E><H><A><R><R><A><M><Q><K><V><M><A><T><T><G><G><M><G><M><G><P><G><G><P><G><M><I><T><I><P><P><S><I><L><N><N><P><N><I><P><N><E><I><I><H><A><L><Q><A><G><R><L><G><S><T><V><F><V><A><N><L><D><Y><K><V><G><W><K><K><L><K><E><V><F><S><M><A><G><V><V><V><R><A><D><I><L><E><D><K><D><G><K><S><R><G><I><G><T><V><T><F><E><Q><S><I><E><A><V><Q><A><I><S><M><F><N><G><Q><L><L><F><D><R><P><M><H><V><K><M><D><E><R><A><L><P><K><G><D><F><F><P><P><E><R><P><Q><Q><L><P><H><G><L><G><G><I><G><M><G><L><G><P><G><G><Q><P><I><D><A><N><H><L><N><K><G><I><G><M><G><N><I><G><P><A><G><M><G><M><E><G><I><G><F><G><I><N><K><M><G><G><M><E><G><P><F><G><G><G><M><E><N><M><G><R><F><G><S><G><M><N><M><G><R><I><N><E><I><L><S><N><A><L><K><R><G><E><I><I><A><K><Q><G><G><G><G><G><G><G><S><V><P><G><I><E><R><M><G><P><G><I><D><R><L><G><G><A><G><M><E><R><M><G><A><G><L><G><H><G><M><D><R><V><G><S><E><I><E><R><M><G><L><V><M><D><R><M><G><S><V><E><R><M><G><S><G><I><E><R><M><G><P><L><G><L><D><H><M><A><S><S><I><E><R><M><G><Q><T><M><E><R><I><G><S><G><V><E><R><M><G><A><G><M><G><F><G><L><E><R><M><A><A><P><I><D><R><V><G><Q><T><I><E><R><M><G><S><G><V><E><R><M><G><P><A><I><E><R><M><G><L><S><M><E><R><M><V><P><A><G><M><G><A><G><L><E><R><M><G><P><V><M><D><R><M><A><T><G><L><E><R><M><G><A><N><N><L><E><R><M><G><L><E><R><M><G><A><N><S><L><E><R><M><G><L><E><R><M><G><A><N><S><L><E><R><M><G><P><A><M><G><P><A><L><G><A><G><I><E><R><M><G><L><A><M><G><G><G><G><G><A><S><F><D><R><A><I><E><M><E><R><G><N><F><G><G><S><F><A><G><S><F><G><G><A><G><G><H><A><P><G><V><A><R><K><A><C><Q><I><F><V><R><N><L><P><F><D><F><T><W><K><M><L><K><D><K><F><N><E><C><G><H><V><L><Y><A><D><I><K><M><E><N><G><K><S><K><G><C><G><V><V><K><F><E><S><P><E><V><A><E><R><A><C><R><M><M><N><G><M><K><L><S><G><R><E><I><D><V><R><I><D><R><N><A>
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Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.<BOP>
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P52272
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P29558
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RBMS1_HUMAN
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Suppressor of CDC2 with RNA-binding motif 2
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Homo
|
<M><G><K><V><W><K><Q><Q><M><Y><P><Q><Y><A><T><Y><Y><Y><P><Q><Y><L><Q><A><K><Q><S><L><V><P><A><H><P><M><A><P><P><S><P><S><T><T><S><S><N><N><N><S><S><S><S><S><N><S><G><W><D><Q><L><S><K><T><N><L><Y><I><R><G><L><P><P><H><T><T><D><Q><D><L><V><K><L><C><Q><P><Y><G><K><I><V><S><T><K><A><I><L><D><K><T><T><N><K><C><K><G><Y><G><F><V><D><F><D><S><P><A><A><A><Q><K><A><V><S><A><L><K><A><S><G><V><Q><A><Q><M><A><K><Q><Q><E><Q><D><P><T><N><L><Y><I><S><N><L><P><L><S><M><D><E><Q><E><L><E><N><M><L><K><P><F><G><Q><V><I><S><T><R><I><L><R><D><S><S><G><T><S><R><G><V><G><F><A><R><M><E><S><T><E><K><C><E><A><V><I><G><H><F><N><G><K><F><I><K><T><P><P><G><V><S><A><P><T><E><P><L><L><C><K><F><A><D><G><G><Q><K><K><R><Q><N><P><N><K><Y><I><P><N><G><R><P><W><H><R><E><G><E><V><R><L><A><G><M><T><L><T><Y><D><P><T><T><A><A><I><Q><N><G><F><Y><P><S><P><Y><S><I><A><T><N><R><M><I><T><Q><T><S><I><T><P><Y><I><A><S><P><V><S><A><Y><Q><V><Q><S><P><S><W><M><Q><P><Q><P><Y><I><L><Q><H><P><G><A><V><L><T><P><S><M><E><H><T><M><S><L><Q><P><A><S><M><I><S><P><L><A><Q><Q><M><S><H><L><S><L><G><S><T><G><T><Y><M><P><A><T><S><A><M><Q><G><A><Y><L><P><Q><Y><A><H><M><Q><T><T><A><V><P><V><E><E><A><S><G><Q><Q><Q><V><A><V><E><T><S><N><D><H><S><P><Y><T><F><Q><P><N><K>
|
Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.<BOP>
|
P29558
|
Q8NGN3
|
O10G4_HUMAN
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Olfactory receptor OR11-278
|
Homo
|
<M><S><N><A><S><L><V><T><A><F><I><L><T><G><L><P><H><A><P><G><L><D><A><L><L><F><G><I><F><L><V><V><Y><V><L><T><V><L><G><N><L><L><I><L><L><V><I><R><V><D><S><H><L><H><T><P><M><Y><Y><F><L><T><N><L><S><F><I><D><M><W><F><S><T><V><T><V><P><K><M><L><M><T><L><V><S><P><S><G><R><A><I><S><F><H><S><C><V><A><Q><L><Y><F><F><H><F><L><G><S><T><E><C><F><L><Y><T><V><M><S><Y><D><R><Y><L><A><I><S><Y><P><L><R><Y><T><S><M><M><S><G><S><R><C><A><L><L><A><T><G><T><W><L><S><G><S><L><H><S><A><V><Q><T><I><L><T><F><H><L><P><Y><C><G><P><N><Q><I><Q><H><Y><F><C><D><A><P><P><I><L><K><L><A><C><A><D><T><S><A><N><V><M><V><I><F><V><D><I><G><I><V><A><S><G><C><F><V><L><I><V><L><S><Y><V><S><I><V><C><S><I><L><R><I><R><T><S><D><G><R><R><R><A><F><Q><T><C><A><S><H><C><I><V><V><L><C><F><F><V><P><C><V><V><I><Y><L><R><P><G><S><M><D><A><M><D><G><V><V><A><I><F><Y><T><V><L><T><P><L><L><N><P><V><V><Y><T><L><R><N><K><E><V><K><K><A><V><L><K><L><R><D><K><V><A><H><P><Q><R><K>
|
Odorant receptor.<BOP>
|
Q8NGN3
|
Q86VW0
|
SESD1_HUMAN
|
Protein Solo
|
Homo
|
<M><E><A><S><V><I><L><P><I><L><K><K><K><L><A><F><L><S><G><G><K><D><R><R><S><G><L><I><L><T><I><P><L><C><L><E><Q><T><N><M><D><E><L><S><V><T><L><D><Y><L><L><S><I><P><S><E><K><C><K><A><R><G><F><T><V><I><V><D><G><R><K><S><Q><W><N><V><V><K><T><V><V><V><M><L><Q><N><V><V><P><A><E><V><S><L><V><C><V><V><K><P><D><E><F><W><D><K><K><V><T><H><F><C><F><W><K><E><K><D><R><L><G><F><E><V><I><L><V><S><A><N><K><L><T><R><Y><I><E><P><C><Q><L><T><E><D><F><G><G><S><L><T><Y><D><H><M><D><W><L><N><K><R><L><V><F><E><K><F><T><K><E><S><T><S><L><L><D><E><L><A><L><I><N><N><G><S><D><K><G><N><Q><Q><E><K><E><R><S><V><D><L><N><F><L><P><S><V><D><P><E><T><V><L><Q><T><G><H><E><L><L><S><E><L><Q><Q><R><R><F><N><G><S><D><G><G><V><S><W><S><P><M><D><D><E><L><L><A><Q><P><Q><V><M><K><L><L><D><S><L><R><E><Q><Y><T><R><Y><Q><E><V><C><R><Q><R><S><K><R><T><Q><L><E><E><I><Q><Q><K><V><M><Q><V><V><N><W><L><E><G><P><G><S><E><Q><L><R><A><Q><W><G><I><G><D><S><I><R><A><S><Q><A><L><Q><Q><K><H><E><E><I><E><S><Q><H><S><E><W><F><A><V><Y><V><E><L><N><Q><Q><I><A><A><L><L><N><A><G><D><E><E><D><L><V><E><L><K><S><L><Q><Q><Q><L><S><D><V><C><Y><R><Q><A><S><Q><L><E><F><R><Q><N><L><L><Q><A><A><L><E><F><H><G><V><A><Q><D><L><S><Q><Q><L><D><G><L><L><G><M><L><C><V><D><V><A><P><A><D><G><A><S><I><Q><Q><T><L><K><L><L><E><E><K><L><K><S><V><D><V><G><L><Q><G><L><R><E><K><G><Q><G><L><L><D><Q><I><S><N><Q><A><S><W><A><Y><G><K><D><V><T><I><E><N><K><E><N><V><D><H><I><Q><G><V><M><E><D><M><Q><L><R><K><Q><R><C><E><D><M><V><D><V><R><R><L><K><M><L><Q><M><V><Q><L><F><K><C><E><E><D><A><A><Q><A><V><E><W><L><S><E><L><L><D><A><L><L><K><T><H><I><R><L><G><D><D><A><Q><E><T><K><V><L><L><E><K><H><R><K><F><V><D><V><A><Q><S><T><Y><D><Y><G><R><Q><L><L><Q><A><T><V><V><L><C><Q><S><L><R><C><T><S><R><S><S><G><D><T><L><P><R><L><N><R><V><W><K><Q><F><T><I><A><S><E><E><R><V><H><R><L><E><M><A><I><A><F><H><S><N><A><E><K><I><L><Q><D><C><P><E><E><P><E><A><I><N><D><E><E><Q><F><D><E><I><E><A><V><G><K><S><L><L><D><R><L><T><V><P><V><V><Y><P><D><G><T><E><Q><Y><F><G><S><P><S><D><M><A><S><T><A><E><N><I><R><D><R><M><K><L><V><N><L><K><R><Q><Q><L><R><H><P><E><M><V><T><T><E><S>
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May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.<BOP>
|
Q86VW0
|
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