accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q96ER3 | SAAL1_HUMAN | Synoviocyte proliferation-associated in collagen-induced arthritis protein 1 | Homo | <M><D><R><N><P><S><P><P><P><P><G><R><D><K><E><E><E><E><E><V><A><G><G><D><C><I><G><S><T><V><Y><S><K><H><W><L><F><G><V><L><S><G><L><I><Q><I><V><S><P><E><N><T><K><S><S><S><D><D><E><E><Q><L><T><E><L><D><E><E><M><E><N><E><I><C><R><V><W><D><M><S><M><D><E><D><V><A><L><F><L><Q><E><F><N><A><P><D><I><F><M><G><V><L><A><K><S><K><C><P><R><L><R><E><I><C><V><G><I><L><G><N><M><A><C><F><Q><E><I><C><V><S><I><S><S><D><K><N><L><G><Q><V><L><L><H><C><L><Y><D><S><D><P><P><T><L><L><E><T><S><R><L><L><L><T><C><L><S><Q><A><E><V><A><S><V><W><V><E><R><I><Q><E><H><P><A><I><Y><D><S><I><C><F><I><M><S><S><S><T><N><V><D><L><L><V><K><V><G><E><V><V><D><K><L><F><D><L><D><E><K><L><M><L><E><W><V><R><N><G><A><A><Q><P><L><D><Q><P><Q><E><E><S><E><E><Q><P><V><F><R><L><V><P><C><I><L><E><A><A><K><Q><V><R><S><E><N><P><E><W><L><D><V><Y><M><H><I><L><Q><L><L><T><T><V><D><D><G><I><Q><A><I><V><H><C><P><D><T><G><K><D><I><W><N><L><L><F><D><L><V><C><H><E><F><C><Q><S><D><D><P><P><I><I><L><Q><E><Q><K><T><V><L><A><S><V><F><S><V><L><S><A><I><Y><A><S><Q><T><E><Q><E><Y><L><K><I><E><K><V><D><L><P><L><I><D><S><L><I><R><V><L><Q><N><M><E><Q><C><Q><K><K><P><E><N><S><A><E><S><N><T><E><E><T><K><R><T><D><L><T><Q><D><D><F><H><L><K><I><L><K><D><I><L><C><E><F><L><S><N><I><F><Q><A><L><T><K><E><T><V><A><Q><G><V><K><E><G><Q><L><S><K><Q><K><C><S><S><A><F><Q><N><L><L><P><F><Y><S><P><V><V><E><D><F><I><K><I><L><R><E><V><D><K><A><L><A><D><D><L><E><K><N><F><P><S><L><K><V><Q><T> | Plays a role in promoting the proliferation of synovial fibroblasts in response to pro-inflammatory stimuli.<BOP> | Q96ER3 |
A8MWA4 | Z705E_HUMAN | zinc finger protein 705E pseudogene | Homo | <M><H><S><L><K><K><V><T><F><E><D><V><A><I><D><F><T><Q><E><E><W><A><M><M><D><T><S><K><R><K><L><Y><R><D><V><M><L><E><N><I><S><H><L><V><S><L><G><Y><Q><I><S><K><S><Y><I><I><L><Q><L><E><Q><G><K><E><L><W><Q><E><G><R><E><F><L><Q><D><Q><N><P><D><R><E><S><A><L><K><K><T><H><M><I><S><M><H><P><I><I><R><K><D><A><P><T><S><M><T><M><E><N><S><L><I><L><E><D><P><F><E><C><N><D><S><G><E><D><C><T><H><S><S><T><I><I><Q><C><L><L><T><H><S><G><K><K><P><Y><V><S><K><Q><C><G><K><S><L><S><N><L><L><S><P><K><P><H><K><Q><I><H><T><K><G><K><S><Y><Q><C><N><L><C><E><K><A><Y><T><N><C><F><H><L><R><R><P><K><M><T><H><T><G><E><R><P><Y><T><C><H><L><C><R><K><A><F><T><Q><C><S><H><L><R><R><H><E><K><T><H><T><G><E><R><P><Y><K><C><H><Q><C><G><K><A><F><I><Q><S><F><N><L><R><R><H><E><R><T><H><L><G><E><K><W><Y><E><C><D><N><S><G><K><A><F><S><Q><S><S><G><F><R><G><N><K><I><I><H><T><G><E><K><P><H><A><C><L><L><C><G><K><A><F><S><L><S><S><D><L><R> | May be involved in transcriptional regulation.<BOP> | A8MWA4 |
O14732 | IMPA2_HUMAN | Myo-inositol monophosphatase A2 | Homo | <M><K><P><S><G><E><D><Q><A><A><L><A><A><G><P><W><E><E><C><F><Q><A><A><V><Q><L><A><L><R><A><G><Q><I><I><R><K><A><L><T><E><E><K><R><V><S><T><K><T><S><A><A><D><L><V><T><E><T><D><H><L><V><E><D><L><I><I><S><E><L><R><E><R><F><P><S><H><R><F><I><A><E><E><A><A><A><S><G><A><K><C><V><L><T><H><S><P><T><W><I><I><D><P><I><D><G><T><C><N><F><V><H><R><F><P><T><V><A><V><S><I><G><F><A><V><R><Q><E><L><E><F><G><V><I><Y><H><C><T><E><E><R><L><Y><T><G><R><R><G><R><G><A><F><C><N><G><Q><R><L><R><V><S><G><E><T><D><L><S><K><A><L><V><L><T><E><I><G><P><K><R><D><P><A><T><L><K><L><F><L><S><N><M><E><R><L><L><H><A><K><A><H><G><V><R><V><I><G><S><S><T><L><A><L><C><H><L><A><S><G><A><A><D><A><Y><Y><Q><F><G><L><H><C><W><D><L><A><A><A><T><V><I><I><R><E><A><G><G><I><V><I><D><T><S><G><G><P><L><D><L><M><A><C><R><V><V><A><A><S><T><R><E><M><A><M><L><I><A><Q><A><L><Q><T><I><N><Y><G><R><D><D><E><K> | Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.<BOP> | O14732 |
Q5VWP3 | MLIP_HUMAN | Muscular-enriched A-type laminin-interacting protein | Homo | <M><E><L><E><K><R><E><K><R><S><L><L><N><K><N><L><E><E><K><L><T><V><S><A><G><G><S><E><A><K><P><L><I><F><T><F><V><P><T><V><R><R><L><P><T><H><T><Q><L><A><D><T><S><K><F><L><V><K><I><P><E><E><S><S><D><K><S><P><E><T><V><N><R><S><K><S><N><D><Y><L><T><L><N><A><G><S><Q><Q><E><R><D><Q><A><K><L><T><C><P><S><E><V><S><G><T><I><L><Q><E><R><E><F><E><A><N><K><L><Q><G><M><Q><Q><S><D><L><F><K><A><E><Y><V><L><I><V><D><S><E><G><E><D><E><A><A><S><R><K><V><E><Q><G><P><P><G><G><I><G><T><A><A><V><R><P><K><S><L><A><I><S><S><S><L><V><S><D><V><V><R><P><K><T><Q><G><T><D><L><K><T><S><S><H><P><E><M><L><H><G><M><A><P><Q><Q><K><H><G><Q><Q><Y><K><T><K><S><S><Y><K><A><F><A><A><I><P><T><N><T><L><L><L><E><Q><K><A><L><D><E><P><A><K><T><E><S><V><S><K><D><N><T><L><E><P><P><V><E><L><Y><F><P><A><Q><L><R><Q><Q><T><E><E><L><C><A><T><I><D><K><V><L><Q><D><S><L><S><M><H><S><S><D><S><P><S><R><S><P><K><T><L><L><G><S><D><T><V><K><T><P><T><T><L><P><R><A><A><G><R><E><T><K><Y><A><N><L><S><S><P><S><S><T><V><S><E><S><Q><L><T><K><P><G><V><I><R><P><V><P><V><K><S><R><I><L><L><K><K><E><E><E><V><Y><E><P><N><P><F><S><K><Y><L><E><D><N><S><D><L><F><S><E><Q><D><V><T><V><P><P><K><P><V><S><L><H><P><L><Y><Q><T><K><L><Y><P><P><A><K><S><L><L><H><P><Q><T><L><S><H><A><D><C><L><A><P><G><P><F><S><H><L><S><F><S><L><S><D><E><Q><E><N><S><H><T><L><L><S><H><N><A><C><N><K><L><S><H><P><M><V><A><I><P><E><H><E><A><L><D><S><K><E><Q> | Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD.<BOP> | Q5VWP3 |
Q96QS3 | ARX_HUMAN | Aristaless-related homeobox | Homo | <M><S><N><Q><Y><Q><E><E><G><C><S><E><R><P><E><C><K><S><K><S><P><T><L><L><S><S><Y><C><I><D><S><I><L><G><R><R><S><P><C><K><M><R><L><L><G><A><A><Q><S><L><P><A><P><L><T><S><R><A><D><P><E><K><A><V><Q><G><S><P><K><S><S><S><A><P><F><E><A><E><L><H><L><P><P><K><L><R><R><L><Y><G><P><G><G><G><R><L><L><Q><G><A><A><A><A><A><A><A><A><A><A><A><A><A><A><A><A><T><A><T><A><G><P><R><G><E><A><P><P><P><P><P><P><T><A><R><P><G><E><R><P><D><G><A><G><A><A><A><A><A><A><A><A><A><A><A><A><W><D><T><L><K><I><S><Q><A><P><Q><V><S><I><S><R><S><K><S><Y><R><E><N><G><A><P><F><V><P><P><P><P><A><L><D><E><L><G><G><P><G><G><V><T><H><P><E><E><R><L><G><V><A><G><G><P><G><S><A><P><A><A><G><G><G><T><G><T><E><D><D><E><E><E><L><L><E><D><E><E><D><E><D><E><E><E><E><L><L><E><D><D><E><E><E><L><L><E><D><D><A><R><A><L><L><K><E><P><R><R><C><P><V><A><A><T><G><A><V><A><A><A><A><A><A><A><V><A><T><E><G><G><E><L><S><P><K><E><E><L><L><L><H><P><E><D><A><E><G><K><D><G><E><D><S><V><C><L><S><A><G><S><D><S><E><E><G><L><L><K><R><K><Q><R><R><Y><R><T><T><F><T><S><Y><Q><L><E><E><L><E><R><A><F><Q><K><T><H><Y><P><D><V><F><T><R><E><E><L><A><M><R><L><D><L><T><E><A><R><V><Q><V><W><F><Q><N><R><R><A><K><W><R><K><R><E><K><A><G><A><Q><T><H><P><P><G><L><P><F><P><G><P><L><S><A><T><H><P><L><S><P><Y><L><D><A><S><P><F><P><P><H><H><P><A><L><D><S><A><W><T><A><A><A><A><A><A><A><A><A><F><P><S><L><P><P><P><P><G><S><A><S><L><P><P><S><G><A><P><L><G><L><S><T><F><L><G><A><A><V><F><R><H><P><A><F><I><S><P><A><F><G><R><L><F><S><T><M><A><P><L><T><S><A><S><T><A><A><A><L><L><R><Q><P><T><P><A><V><E><G><A><V><A><S><G><A><L><A><D><P><A><T><A><A><A><D><R><R><A><S><S><I><A><A><L><R><L><K><A><K><E><H><A><A><Q><L><T><Q><L><N><I><L><P><G><T><S><T><G><K><E><V><C> | Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate.<BOP> | Q96QS3 |
Q7Z7L7 | ZER1_HUMAN | Zyg11b-like protein | Homo | <M><A><S><D><T><P><E><S><L><M><A><L><C><T><D><F><C><L><R><N><L><D><G><T><L><G><Y><L><L><D><K><E><T><L><R><L><H><P><D><I><F><L><P><S><E><I><C><D><R><L><V><N><E><Y><V><E><L><V><N><A><A><C><N><F><E><P><H><E><S><F><F><S><L><F><S><D><P><R><S><T><R><L><T><R><I><H><L><R><E><D><L><V><Q><D><Q><D><L><E><A><I><R><K><Q><D><L><V><E><L><Y><L><T><N><C><E><K><L><S><A><K><S><L><Q><T><L><R><S><F><S><H><T><L><V><S><L><S><L><F><G><C><T><N><I><F><Y><E><E><E><N><P><G><G><C><E><D><E><Y><L><V><N><P><T><C><Q><V><L><V><K><D><F><T><F><E><G><F><S><R><L><R><F><L><N><L><G><R><M><I><D><W><V><P><V><E><S><L><L><R><P><L><N><S><L><A><A><L><D><L><S><G><I><Q><T><S><D><A><A><F><L><T><Q><W><K><D><S><L><V><S><L><V><L><Y><N><M><D><L><S><D><D><H><I><R><V><I><V><Q><L><H><K><L><R><H><L><D><I><S><R><D><R><L><S><S><Y><Y><K><F><K><L><T><R><E><V><L><S><L><F><V><Q><K><L><G><N><L><M><S><L><D><I><S><G><H><M><I><L><E><N><C><S><I><S><K><M><E><E><E><A><G><Q><T><S><I><E><P><S><K><S><S><I><I><P><F><R><A><L><K><R><P><L><Q><F><L><G><L><F><E><N><S><L><C><R><L><T><H><I><P><A><Y><K><V><S><G><D><K><N><E><E><Q><V><L><N><A><I><E><A><Y><T><E><H><R><P><E><I><T><S><R><A><I><N><L><L><F><D><I><A><R><I><E><R><C><N><Q><L><L><R><A><L><K><L><V><I><T><A><L><K><C><H><K><Y><D><R><N><I><Q><V><T><G><S><A><A><L><F><Y><L><T><N><S><E><Y><R><S><E><Q><S><V><K><L><R><R><Q><V><I><Q><V><V><L><N><G><M><E><S><Y><Q><E><V><T><V><Q><R><N><C><C><L><T><L><C><N><F><S><I><P><E><E><L><E><F><Q><Y><R><R><V><N><E><L><L><L><S><I><L><N><P><T><R><Q><D><E><S><I><Q><R><I><A><V><H><L><C><N><A><L><V><C><Q><V><D><N><D><H><K><E><A><V><G><K><M><G><F><V><V><T><M><L><K><L><I><Q><K><K><L><L><D><K><T><C><D><Q><V><M><E><F><S><W><S><A><L><W><N><I><T><D><E><T><P><D><N><C><E><M><F><L><N><F><N><G><M><K><L><F><L><D><C><L><K><E><F><P><E><K><Q><E><L><H><R><N><M><L><G><L><L><G><N><V><A><E><V><K><E><L><R><P><Q><L><M><T><S><Q><F><I><S><V><F><S><N><L><L><E><S><K><A><D><G><I><E><V><S><Y><N><A><C><G><V><L><S><H><I><M><F><D><G><P><E><A><W><G><V><C><E><P><Q><R><E><E><V><E><E><R><M><W><A><A><I><Q><S><W><D><I><N><S><R><R><N><I><N><Y><R><S><F><E><P><I><L><R><L><L><P><Q><G><I><S><P><V><S><Q><H><W><A><T><W><A><L><Y><N><L><V><S><V><Y><P><D><K><Y><C><P><L><L><I><K><E><G><G><M><P><L><L><R><D><I><I><K><M><A><T><A><R><Q><E><T><K><E><M><A><R><K><V><I><E><H><C><S><N><F><K><E><E><N><M><D><T><S><R> | Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC . Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation . Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation .<BOP> | Q7Z7L7 |
Q02750 | MP2K1_HUMAN | MAPK/ERK kinase 1 | Homo | <M><P><K><K><K><P><T><P><I><Q><L><N><P><A><P><D><G><S><A><V><N><G><T><S><S><A><E><T><N><L><E><A><L><Q><K><K><L><E><E><L><E><L><D><E><Q><Q><R><K><R><L><E><A><F><L><T><Q><K><Q><K><V><G><E><L><K><D><D><D><F><E><K><I><S><E><L><G><A><G><N><G><G><V><V><F><K><V><S><H><K><P><S><G><L><V><M><A><R><K><L><I><H><L><E><I><K><P><A><I><R><N><Q><I><I><R><E><L><Q><V><L><H><E><C><N><S><P><Y><I><V><G><F><Y><G><A><F><Y><S><D><G><E><I><S><I><C><M><E><H><M><D><G><G><S><L><D><Q><V><L><K><K><A><G><R><I><P><E><Q><I><L><G><K><V><S><I><A><V><I><K><G><L><T><Y><L><R><E><K><H><K><I><M><H><R><D><V><K><P><S><N><I><L><V><N><S><R><G><E><I><K><L><C><D><F><G><V><S><G><Q><L><I><D><S><M><A><N><S><F><V><G><T><R><S><Y><M><S><P><E><R><L><Q><G><T><H><Y><S><V><Q><S><D><I><W><S><M><G><L><S><L><V><E><M><A><V><G><R><Y><P><I><P><P><P><D><A><K><E><L><E><L><M><F><G><C><Q><V><E><G><D><A><A><E><T><P><P><R><P><R><T><P><G><R><P><L><S><S><Y><G><M><D><S><R><P><P><M><A><I><F><E><L><L><D><Y><I><V><N><E><P><P><P><K><L><P><S><G><V><F><S><L><E><F><Q><D><F><V><N><K><C><L><I><K><N><P><A><E><R><A><D><L><K><Q><L><M><V><H><A><F><I><K><R><S><D><A><E><E><V><D><F><A><G><W><L><C><S><T><I><G><L><N><Q><P><S><T><P><T><H><A><A><G><V> | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation . Depending on the | Q02750 |
P15056 | BRAF_HUMAN | v-Raf murine sarcoma viral oncogene homolog B1 | Homo | <M><A><A><L><S><G><G><G><G><G><G><A><E><P><G><Q><A><L><F><N><G><D><M><E><P><E><A><G><A><G><A><G><A><A><A><S><S><A><A><D><P><A><I><P><E><E><V><W><N><I><K><Q><M><I><K><L><T><Q><E><H><I><E><A><L><L><D><K><F><G><G><E><H><N><P><P><S><I><Y><L><E><A><Y><E><E><Y><T><S><K><L><D><A><L><Q><Q><R><E><Q><Q><L><L><E><S><L><G><N><G><T><D><F><S><V><S><S><S><A><S><M><D><T><V><T><S><S><S><S><S><S><L><S><V><L><P><S><S><L><S><V><F><Q><N><P><T><D><V><A><R><S><N><P><K><S><P><Q><K><P><I><V><R><V><F><L><P><N><K><Q><R><T><V><V><P><A><R><C><G><V><T><V><R><D><S><L><K><K><A><L><M><M><R><G><L><I><P><E><C><C><A><V><Y><R><I><Q><D><G><E><K><K><P><I><G><W><D><T><D><I><S><W><L><T><G><E><E><L><H><V><E><V><L><E><N><V><P><L><T><T><H><N><F><V><R><K><T><F><F><T><L><A><F><C><D><F><C><R><K><L><L><F><Q><G><F><R><C><Q><T><C><G><Y><K><F><H><Q><R><C><S><T><E><V><P><L><M><C><V><N><Y><D><Q><L><D><L><L><F><V><S><K><F><F><E><H><H><P><I><P><Q><E><E><A><S><L><A><E><T><A><L><T><S><G><S><S><P><S><A><P><A><S><D><S><I><G><P><Q><I><L><T><S><P><S><P><S><K><S><I><P><I><P><Q><P><F><R><P><A><D><E><D><H><R><N><Q><F><G><Q><R><D><R><S><S><S><A><P><N><V><H><I><N><T><I><E><P><V><N><I><D><D><L><I><R><D><Q><G><F><R><G><D><G><G><S><T><T><G><L><S><A><T><P><P><A><S><L><P><G><S><L><T><N><V><K><A><L><Q><K><S><P><G><P><Q><R><E><R><K><S><S><S><S><S><E><D><R><N><R><M><K><T><L><G><R><R><D><S><S><D><D><W><E><I><P><D><G><Q><I><T><V><G><Q><R><I><G><S><G><S><F><G><T><V><Y><K><G><K><W><H><G><D><V><A><V><K><M><L><N><V><T><A><P><T><P><Q><Q><L><Q><A><F><K><N><E><V><G><V><L><R><K><T><R><H><V><N><I><L><L><F><M><G><Y><S><T><K><P><Q><L><A><I><V><T><Q><W><C><E><G><S><S><L><Y><H><H><L><H><I><I><E><T><K><F><E><M><I><K><L><I><D><I><A><R><Q><T><A><Q><G><M><D><Y><L><H><A><K><S><I><I><H><R><D><L><K><S><N><N><I><F><L><H><E><D><L><T><V><K><I><G><D><F><G><L><A><T><V><K><S><R><W><S><G><S><H><Q><F><E><Q><L><S><G><S><I><L><W><M><A><P><E><V><I><R><M><Q><D><K><N><P><Y><S><F><Q><S><D><V><Y><A><F><G><I><V><L><Y><E><L><M><T><G><Q><L><P><Y><S><N><I><N><N><R><D><Q><I><I><F><M><V><G><R><G><Y><L><S><P><D><L><S><K><V><R><S><N><C><P><K><A><M><K><R><L><M><A><E><C><L><K><K><K><R><D><E><R><P><L><F><P><Q><I><L><A><S><I><E><L><L><A><R><S><L><P><K><I><H><R><S><A><S><E><P><S><L><N><R><A><G><F><Q><T><E><D><F><S><L><Y><A><C><A><S><P><K><T><P><I><Q><A><G><G><Y><G><A><F><P><V><H> | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway . May play a role in the postsynaptic responses of hippocampal neurons .<BOP> | P15056 |
A0A0C4DH33 | HV124_HUMAN | Immunoglobulin heavy variable 1-24 | Homo | <M><D><C><T><W><R><I><L><F><L><V><A><A><A><T><G><T><H><A><Q><V><Q><L><V><Q><S><G><A><E><V><K><K><P><G><A><S><V><K><V><S><C><K><V><S><G><Y><T><L><T><E><L><S><M><H><W><V><R><Q><A><P><G><K><G><L><E><W><M><G><G><F><D><P><E><D><G><E><T><I><Y><A><Q><K><F><Q><G><R><V><T><M><T><E><D><T><S><T><D><T><A><Y><M><E><L><S><S><L><R><S><E><D><T><A><V><Y><Y><C><A><T> | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | A0A0C4DH33 |
Q30KQ9 | DB110_HUMAN | Defensin, beta 111 | Homo | <M><K><I><Q><L><F><F><F><I><L><H><F><W><V><T><I><L><P><A><K><K><K><Y><P><E><Y><G><S><L><D><L><R><R><E><C><R><I><G><N><G><Q><C><K><N><Q><C><H><E><N><E><I><R><I><A><Y><C><I><R><P><G><T><H><C><C><L><Q><Q> | Has antibacterial activity.<BOP> | Q30KQ9 |
A0A5B9 | TRBC2_HUMAN | T cell receptor beta constant 2 | Homo | <D><L><K><N><V><F><P><P><K><V><A><V><F><E><P><S><E><A><E><I><S><H><T><Q><K><A><T><L><V><C><L><A><T><G><F><Y><P><D><H><V><E><L><S><W><W><V><N><G><K><E><V><H><S><G><V><S><T><D><P><Q><P><L><K><E><Q><P><A><L><N><D><S><R><Y><C><L><S><S><R><L><R><V><S><A><T><F><W><Q><N><P><R><N><H><F><R><C><Q><V><Q><F><Y><G><L><S><E><N><D><E><W><T><Q><D><R><A><K><P><V><T><Q><I><V><S><A><E><A><W><G><R><A><D><C><G><F><T><S><E><S><Y><Q><Q><G><V><L><S><A><T><I><L><Y><E><I><L><L><G><K><A><T><L><Y><A><V><L><V><S><A><L><V><L><M><A><M><V><K><R><K><D><S><R><G> | Constant region of T cell receptor (TR) beta chain . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrath | A0A5B9 |
Q8IYS5 | OSCAR_HUMAN | Polymeric immunoglobulin receptor 3 | Homo | <M><A><L><V><L><I><L><Q><L><L><T><L><W><P><L><C><H><T><D><I><T><P><S><V><P><P><A><S><Y><H><P><K><P><W><L><G><A><Q><P><A><T><V><V><T><P><G><V><N><V><T><L><R><C><R><A><P><Q><P><A><W><R><F><G><L><F><K><P><G><E><I><A><P><L><L><F><R><D><V><S><S><E><L><A><E><F><F><L><E><E><V><T><P><A><Q><G><G><I><Y><R><C><C><Y><R><R><P><D><W><G><P><G><V><W><S><Q><P><S><D><V><L><E><L><L><V><T><E><E><L><P><R><P><S><L><V><A><L><P><G><P><V><V><G><P><G><A><N><V><S><L><R><C><A><G><R><L><R><N><M><S><F><V><L><Y><R><E><G><V><A><A><P><L><Q><Y><R><H><S><A><Q><P><W><A><D><F><T><L><L><G><A><R><A><P><G><T><Y><S><C><Y><Y><H><T><P><S><A><P><Y><V><L><S><Q><R><S><E><V><L><V><I><S><W><E><G><E><G><P><E><A><R><P><A><S><S><A><P><G><M><Q><A><P><G><P><P><P><S><D><P><G><A><Q><A><P><S><L><S><S><F><R><P><R><G><L><V><L><Q><P><L><L><P><Q><T><Q><D><S><W><D><P><A><P><P><P><S><D><P><G><V> | Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.<BOP> | Q8IYS5 |
Q8IYA6 | CKP2L_HUMAN | Radial fiber and mitotic spindle protein | Homo | <M><V><G><P><G><P><T><A><A><A><A><V><E><E><R><Q><R><K><L><Q><E><Y><L><A><A><K><G><K><L><K><S><Q><N><T><K><P><Y><L><K><S><K><N><N><C><Q><N><Q><P><P><S><K><S><T><I><R><P><K><N><D><V><T><N><H><V><V><L><P><V><K><P><K><R><S><I><S><I><K><L><Q><P><R><P><P><N><T><A><G><S><Q><K><P><K><L><E><P><P><K><L><L><G><K><R><L><T><S><E><C><V><S><S><N><P><Y><S><K><P><S><S><K><S><F><Q><Q><C><E><A><G><S><S><T><T><G><E><L><S><R><K><P><V><G><S><L><N><I><E><Q><L><K><T><T><K><Q><Q><L><T><D><Q><G><N><G><K><C><I><D><F><M><N><N><I><H><V><E><N><E><S><L><D><N><F><L><K><E><T><N><K><E><N><L><L><D><I><L><T><E><P><E><R><K><P><D><P><K><L><Y><T><R><S><K><P><K><T><D><S><Y><N><Q><T><K><N><S><L><V><P><K><Q><A><L><G><K><S><S><V><N><S><A><V><L><K><D><R><V><N><K><Q><F><V><G><E><T><Q><S><R><T><F><P><V><K><S><Q><Q><L><S><R><G><A><D><L><A><R><P><G><V><K><P><S><R><T><V><P><S><H><F><I><R><T><L><S><K><V><Q><S><S><K><K><P><V><V><K><N><I><K><D><I><K><V><N><R><S><Q><Y><E><R><P><N><E><T><K><I><R><S><Y><P><V><T><E><Q><R><V><K><H><T><K><P><R><T><Y><P><S><L><L><Q><G><E><Y><N><N><R><H><P><N><I><K><Q><D><Q><K><S><S><Q><V><C><I><P><Q><T><S><C><V><L><Q><K><S><K><A><I><S><Q><R><P><N><L><T><V><G><R><F><N><S><A><I><P><S><T><P><S><I><R><P><N><G><T><S><G><N><K><H><N><N><N><G><F><Q><Q><K><A><Q><T><L><D><S><K><L><K><K><A><V><P><Q><N><H><F><L><N><K><T><A><P><K><T><Q><A><D><V><T><T><V><N><G><T><Q><T><N><P><N><I><K><K><K><A><T><A><E><D><R><R><K><Q><L><E><E><W><Q><K><S><K><G><K><T><Y><K><R><P><P><M><E><L><K><T><K><R><K><V><I><K><E><M><N><I><S><F><W><K><S><I><E><K><E><E><E><E><K><K><A><Q><L><E><L><S><S><K><I><N><N><T><L><T><E><C><L><N><L><I><E><G><G><V><P><S><N><E><I><L><N><I><L><S><S><I><P><E><A><E><K><F><A><K><F><W><I><C><K><A><K><L><L><A><S><K><G><T><F><D><V><I><G><L><Y><E><E><A><I><K><N><G><A><T><P><I><Q><E><L><R><K><V><V><L><N><I><L><Q><D><S><N><R><T><T><E><G><I><T><S><D><S><L><V><A><E><T><S><I><T><S><V><E><E><L><A><K><K><M><E><S><V><K><S><C><L><S><P><K><E><R><E><Q><V><T><A><T><P><R><I><A><K><A><E><Q><H><N><Y><P><G><I><K><L><Q><I><G><P><I><P><R><I><N><G><M><P><E><V><Q><D><M><K><F><I><T><P><V><R><R><S><S><R><I><E><R><A><V><S><R><Y><P><E><M><L><Q><E><H><D><L><V><V><A><S><L><D><E><L><L><E><V><E><E><T><K><C><F><I><F><R><R><N><E><A><L><P><V><T><L><G><F><Q><T><P><E><S> | Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells.<BOP> | Q8IYA6 |
P07360 | CO8G_HUMAN | Complement component C8 gamma chain | Homo | <M><L><P><P><G><T><A><T><L><L><T><L><L><L><A><A><G><S><L><G><Q><K><P><Q><R><P><R><R><P><A><S><P><I><S><T><I><Q><P><K><A><N><F><D><A><Q><Q><F><A><G><T><W><L><L><V><A><V><G><S><A><C><R><F><L><Q><E><Q><G><H><R><A><E><A><T><T><L><H><V><A><P><Q><G><T><A><M><A><V><S><T><F><R><K><L><D><G><I><C><W><Q><V><R><Q><L><Y><G><D><T><G><V><L><G><R><F><L><L><Q><A><R><D><A><R><G><A><V><H><V><V><V><A><E><T><D><Y><Q><S><F><A><V><L><Y><L><E><R><A><G><Q><L><S><V><K><L><Y><A><R><S><L><P><V><S><D><S><V><L><S><G><F><E><Q><R><V><Q><E><A><H><L><T><E><D><Q><I><F><Y><F><P><K><Y><G><F><C><E><A><A><D><Q><F><H><V><L><D><E><V><R><R> | C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.<BOP> | P07360 |
O76082 | S22A5_HUMAN | Organic cation/carnitine transporter 2 | Homo | <M><R><D><Y><D><E><V><T><A><F><L><G><E><W><G><P><F><Q><R><L><I><F><F><L><L><S><A><S><I><I><P><N><G><F><T><G><L><S><S><V><F><L><I><A><T><P><E><H><R><C><R><V><P><D><A><A><N><L><S><S><A><W><R><N><H><T><V><P><L><R><L><R><D><G><R><E><V><P><H><S><C><R><R><Y><R><L><A><T><I><A><N><F><S><A><L><G><L><E><P><G><R><D><V><D><L><G><Q><L><E><Q><E><S><C><L><D><G><W><E><F><S><Q><D><V><Y><L><S><T><I><V><T><E><W><N><L><V><C><E><D><D><W><K><A><P><L><T><I><S><L><F><F><V><G><V><L><L><G><S><F><I><S><G><Q><L><S><D><R><F><G><R><K><N><V><L><F><V><T><M><G><M><Q><T><G><F><S><F><L><Q><I><F><S><K><N><F><E><M><F><V><V><L><F><V><L><V><G><M><G><Q><I><S><N><Y><V><A><A><F><V><L><G><T><E><I><L><G><K><S><V><R><I><I><F><S><T><L><G><V><C><I><F><Y><A><F><G><Y><M><V><L><P><L><F><A><Y><F><I><R><D><W><R><M><L><L><V><A><L><T><M><P><G><V><L><C><V><A><L><W><W><F><I><P><E><S><P><R><W><L><I><S><Q><G><R><F><E><E><A><E><V><I><I><R><K><A><A><K><A><N><G><I><V><V><P><S><T><I><F><D><P><S><E><L><Q><D><L><S><S><K><K><Q><Q><S><H><N><I><L><D><L><L><R><T><W><N><I><R><M><V><T><I><M><S><I><M><L><W><M><T><I><S><V><G><Y><F><G><L><S><L><D><T><P><N><L><H><G><D><I><F><V><N><C><F><L><S><A><M><V><E><V><P><A><Y><V><L><A><W><L><L><L><Q><Y><L><P><R><R><Y><S><M><A><T><A><L><F><L><G><G><S><V><L><L><F><M><Q><L><V><P><P><D><L><Y><Y><L><A><T><V><L><V><M><V><G><K><F><G><V><T><A><A><F><S><M><V><Y><V><Y><T><A><E><L><Y><P><T><V><V><R><N><M><G><V><G><V><S><S><T><A><S><R><L><G><S><I><L><S><P><Y><F><V><Y><L><G><A><Y><D><R><F><L><P><Y><I><L><M><G><S><L><T><I><L><T><A><I><L><T><L><F><L><P><E><S><F><G><T><P><L><P><D><T><I><D><Q><M><L><R><V><K><G><M><K><H><R><K><T><P><S><H><T><R><M><L><K><D><G><Q><E><R><P><T><I><L><K><S><T><A><F> | Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.<BOP> | O76082 |
Q86UL3 | GPAT4_HUMAN | Testis spermatogenesis apoptosis-related protein 7 | Homo | <M><F><L><L><L><P><F><D><S><L><I><V><N><L><L><G><I><S><L><T><V><L><F><T><L><L><L><V><F><I><I><V><P><A><I><F><G><V><S><F><G><I><R><K><L><Y><M><K><S><L><L><K><I><F><A><W><A><T><L><R><M><E><R><G><A><K><E><K><N><H><Q><L><Y><K><P><Y><T><N><G><I><I><A><K><D><P><T><S><L><E><E><E><I><K><E><I><R><R><S><G><S><S><K><A><L><D><N><T><P><E><F><E><L><S><D><I><F><Y><F><C><R><K><G><M><E><T><I><M><D><D><E><V><T><K><R><F><S><A><E><E><L><E><S><W><N><L><L><S><R><T><N><Y><N><F><Q><Y><I><S><L><R><L><T><V><L><W><G><L><G><V><L><I><R><Y><C><F><L><L><P><L><R><I><A><L><A><F><T><G><I><S><L><L><V><V><G><T><T><V><V><G><Y><L><P><N><G><R><F><K><E><F><M><S><K><H><V><H><L><M><C><Y><R><I><C><V><R><A><L><T><A><I><I><T><Y><H><D><R><E><N><R><P><R><N><G><G><I><C><V><A><N><H><T><S><P><I><D><V><I><I><L><A><S><D><G><Y><Y><A><M><V><G><Q><V><H><G><G><L><M><G><V><I><Q><R><A><M><V><K><A><C><P><H><V><W><F><E><R><S><E><V><K><D><R><H><L><V><A><K><R><L><T><E><H><V><Q><D><K><S><K><L><P><I><L><I><F><P><E><G><T><C><I><N><N><T><S><V><M><M><F><K><K><G><S><F><E><I><G><A><T><V><Y><P><V><A><I><K><Y><D><P><Q><F><G><D><A><F><W><N><S><S><K><Y><G><M><V><T><Y><L><L><R><M><M><T><S><W><A><I><V><C><S><V><W><Y><L><P><P><M><T><R><E><A><D><E><D><A><V><Q><F><A><N><R><V><K><S><A><I><A><R><Q><G><G><L><V><D><L><L><W><D><G><G><L><K><R><E><K><V><K><D><T><F><K><E><E><Q><Q><K><L><Y><S><K><M><I><V><G><N><H><K><D><R><S><R><S> | Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone . Active against both saturated and unsaturated long-chain fatty acyl-CoAs . Protects cells against lipotoxicity .<BOP> | Q86UL3 |
Q8NGE9 | OR9Q2_HUMAN | Olfactory receptor 9Q2 | Homo | <M><A><E><R><N><Y><T><V><V><T><E><F><F><L><T><A><F><T><E><H><L><Q><W><R><V><P><L><F><L><I><F><L><S><F><Y><L><A><T><M><L><G><N><T><G><M><I><L><L><I><R><G><D><R><R><L><H><T><P><M><Y><F><F><L><S><H><L><S><L><V><D><I><C><Y><S><S><A><I><I><P><Q><M><L><A><V><L><W><E><H><G><T><T><I><S><Q><A><R><C><A><A><Q><F><F><L><F><T><F><F><A><S><I><D><C><Y><L><L><A><I><M><A><Y><D><R><Y><T><A><V><C><Q><P><L><L><Y><V><T><I><I><T><E><K><A><R><W><G><L><V><T><G><A><Y><V><A><G><F><F><S><A><F><V><R><T><V><T><A><F><T><L><S><F><C><G><N><N><E><I><N><F><I><F><C><D><L><P><P><L><L><K><L><S><C><G><D><S><Y><T><Q><E><V><V><I><I><V><F><A><L><F><V><M><P><A><C><I><L><V><I><L><V><S><Y><L><F><I><I><V><A><I><L><Q><I><H><S><A><G><G><R><A><K><T><F><S><T><C><A><S><H><L><T><A><V><A><L><F><F><G><T><L><I><F><M><Y><L><R><D><N><T><G><Q><S><S><E><G><D><R><V><V><S><V><L><Y><T><V><V><T><P><M><L><N><P><L><I><Y><S><L><R><N><K><E><V><K><E><A><T><R><K><A><L><S><K><S><K><P><A><R><R><P> | Odorant receptor.<BOP> | Q8NGE9 |
Q15050 | RRS1_HUMAN | Ribosome biogenesis regulatory protein homolog | Homo | <M><E><G><Q><S><V><E><E><L><L><A><K><A><E><Q><D><E><A><E><K><L><Q><R><I><T><V><H><K><E><L><E><L><Q><F><D><L><G><N><L><L><A><S><D><R><N><P><P><T><G><L><R><C><A><G><P><T><P><E><A><E><L><Q><A><L><A><R><D><N><T><Q><L><L><I><N><Q><L><W><Q><L><P><T><E><R><V><E><E><A><I><V><A><R><L><P><E><P><T><T><R><L><P><R><E><K><P><L><P><R><P><R><P><L><T><R><W><Q><Q><F><A><R><L><K><G><I><R><P><K><K><K><T><N><L><V><W><D><E><V><S><G><Q><W><R><R><R><W><G><Y><Q><R><A><R><D><D><T><K><E><W><L><I><E><V><P><G><N><A><D><P><L><E><D><Q><F><A><K><R><I><Q><A><K><K><E><R><V><A><K><N><E><L><N><R><L><R><N><L><A><R><A><H><K><M><Q><L><P><S><A><A><G><L><H><P><T><G><H><Q><S><K><E><E><L><G><R><A><M><Q><V><A><K><V><S><T><A><S><V><G><R><F><Q><E><R><L><P><K><E><K><V><P><R><G><S><G><K><K><R><K><F><Q><P><L><F><G><D><F><A><A><E><K><K><N><Q><L><E><L><L><R><V><M><N><S><K><K><P><Q><L><D><V><T><R><A><T><N><K><Q><M><R><E><E><D><Q><E><E><A><A><K><R><R><K><M><S><Q><K><G><K><R><K><G><G><R><Q><G><P><G><G><K><R><K><G><G><P><P><S><Q><G><G><K><R><K><G><G><L><G><G><K><M><N><S><G><P><P><G><L><G><G><K><R><K><G><G><Q><R><P><G><G><K><R><R><K> | Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.<BOP> | Q15050 |
Q92624 | APBP2_HUMAN | Protein interacting with APP tail 1 | Homo | <M><A><A><V><E><L><E><W><I><P><E><T><L><Y><N><T><A><I><S><A><V><V><D><N><Y><I><R><S><R><R><D><I><R><S><L><P><E><N><I><Q><F><D><V><Y><Y><K><L><Y><Q><Q><G><R><L><C><Q><L><G><S><E><F><C><E><L><E><V><F><A><K><V><L><R><A><L><D><K><R><H><L><L><H><H><C><F><Q><A><L><M><D><H><G><V><K><V><A><S><V><L><A><Y><S><F><S><R><R><C><S><Y><I><A><E><S><D><A><A><V><K><E><K><A><I><Q><V><G><F><V><L><G><G><F><L><S><D><A><G><W><Y><S><D><A><E><K><V><F><L><S><C><L><Q><L><C><T><L><H><D><E><M><L><H><W><F><R><A><V><E><C><C><V><R><L><L><H><V><R><N><G><N><C><K><Y><H><L><G><E><E><T><F><K><L><A><Q><T><Y><M><D><K><L><S><K><H><G><Q><Q><A><N><K><A><A><L><Y><G><E><L><C><A><L><L><F><A><K><S><H><Y><D><E><A><Y><K><W><C><I><E><A><M><K><E><I><T><A><G><L><P><V><K><V><V><V><D><V><L><R><Q><A><S><K><A><C><V><V><K><R><E><F><K><K><A><E><Q><L><I><K><H><A><V><Y><L><A><R><D><H><F><G><S><K><H><P><K><Y><S><D><T><L><L><D><Y><G><F><Y><L><L><N><V><D><N><I><C><Q><S><V><A><I><Y><Q><A><A><L><D><I><R><Q><S><V><F><G><G><K><N><I><H><V><A><T><A><H><E><D><L><A><Y><S><S><Y><V><H><Q><Y><S><S><G><K><F><D><N><A><L><F><H><A><E><R><A><I><G><I><I><T><H><I><L><P><E><D><H><L><L><L><A><S><S><K><R><V><K><A><L><I><L><E><E><I><A><I><D><C><H><N><K><E><T><E><Q><R><L><L><Q><E><A><H><D><L><H><L><S><S><L><Q><L><A><K><K><A><F><G><E><F><N><V><Q><T><A><K><H><Y><G><N><L><G><R><L><Y><Q><S><M><R><K><F><K><E><A><E><E><M><H><I><K><A><I><Q><I><K><E><Q><L><L><G><Q><E><D><Y><E><V><A><L><S><V><G><H><L><A><S><L><Y><N><Y><D><M><N><Q><Y><E><N><A><E><K><L><Y><L><R><S><I><A><I><G><K><K><L><F><G><E><G><Y><S><G><L><E><Y><D><Y><R><G><L><I><K><L><Y><N><S><I><G><N><Y><E><K><V><F><E><Y><H><N><V><L><S><N><W><N><R><L><R><D><R><Q><Y><S><V><T><D><A><L><E><D><V><S><T><S><P><Q><S><T><E><E><V><V><Q><S><F><L><I><S><Q><N><V><E><G><P><S><C> | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation . The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron . May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface .<BOP> | Q92624 |
Q7L8S5 | OTU6A_HUMAN | DUBA-2 | Homo | <M><D><D><P><K><S><E><Q><Q><R><I><L><R><R><H><Q><R><E><R><Q><E><L><Q><A><Q><I><R><S><L><K><N><S><V><P><K><T><D><K><T><K><R><K><Q><L><L><Q><D><V><A><R><M><E><A><E><M><A><Q><K><H><R><Q><E><L><E><K><F><Q><D><D><S><S><I><E><S><V><V><E><D><L><A><K><M><N><L><E><N><R><P><P><R><S><S><K><A><H><R><K><R><E><R><M><E><S><E><E><R><E><R><Q><E><S><I><F><Q><A><E><M><S><E><H><L><A><G><F><K><R><E><E><E><E><K><L><A><A><I><L><G><A><R><G><L><E><M><K><A><I><P><A><D><G><H><C><M><Y><R><A><I><Q><D><Q><L><V><F><S><V><S><V><E><M><L><R><C><R><T><A><S><Y><M><K><K><H><V><D><E><F><L><P><F><F><S><N><P><E><T><S><D><S><F><G><Y><D><D><F><M><I><Y><C><D><N><I><V><R><T><T><A><W><G><G><Q><L><E><L><R><A><L><S><H><V><L><K><T><P><I><E><V><I><Q><A><D><S><P><T><L><I><I><G><E><E><Y><V><K><K><P><I><I><L><V><Y><L><R><Y><A><Y><S><L><G><E><H><Y><N><S><V><T><P><L><E><A><G><A><A><G><G><V><L><P><R><L><L> | Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains.<BOP> | Q7L8S5 |
P51681 | CCR5_HUMAN | HIV-1 fusion coreceptor | Homo | <M><D><Y><Q><V><S><S><P><I><Y><D><I><N><Y><Y><T><S><E><P><C><Q><K><I><N><V><K><Q><I><A><A><R><L><L><P><P><L><Y><S><L><V><F><I><F><G><F><V><G><N><M><L><V><I><L><I><L><I><N><C><K><R><L><K><S><M><T><D><I><Y><L><L><N><L><A><I><S><D><L><F><F><L><L><T><V><P><F><W><A><H><Y><A><A><A><Q><W><D><F><G><N><T><M><C><Q><L><L><T><G><L><Y><F><I><G><F><F><S><G><I><F><F><I><I><L><L><T><I><D><R><Y><L><A><V><V><H><A><V><F><A><L><K><A><R><T><V><T><F><G><V><V><T><S><V><I><T><W><V><V><A><V><F><A><S><L><P><G><I><I><F><T><R><S><Q><K><E><G><L><H><Y><T><C><S><S><H><F><P><Y><S><Q><Y><Q><F><W><K><N><F><Q><T><L><K><I><V><I><L><G><L><V><L><P><L><L><V><M><V><I><C><Y><S><G><I><L><K><T><L><L><R><C><R><N><E><K><K><R><H><R><A><V><R><L><I><F><T><I><M><I><V><Y><F><L><F><W><A><P><Y><N><I><V><L><L><L><N><T><F><Q><E><F><F><G><L><N><N><C><S><S><S><N><R><L><D><Q><A><M><Q><V><T><E><T><L><G><M><T><H><C><C><I><N><P><I><I><Y><A><F><V><G><E><K><F><R><N><Y><L><L><V><F><F><Q><K><H><I><A><K><R><F><C><K><C><C><S><I><F><Q><Q><E><A><P><E><R><A><S><S><V><Y><T><R><S><T><G><E><Q><E><I><S><V><G><L> | (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.<BOP> | P51681 |
Q7RTX9 | MOT14_HUMAN | Solute carrier family 16 member 14 | Homo | <M><Y><T><S><H><E><D><I><G><Y><D><F><E><D><G><P><K><D><K><K><T><L><K><P><H><P><N><I><D><G><G><W><A><W><M><M><V><L><S><S><F><F><V><H><I><L><I><M><G><S><Q><M><A><L><G><V><L><N><V><E><W><L><E><E><F><H><Q><S><R><G><L><T><A><W><V><S><S><L><S><M><G><I><T><L><I><V><G><P><F><I><G><L><F><I><N><T><C><G><C><R><Q><T><A><I><I><G><G><L><V><N><S><L><G><W><V><L><S><A><Y><A><A><N><V><H><Y><L><F><I><T><F><G><V><A><A><G><L><G><S><G><M><A><Y><L><P><A><V><V><M><V><G><R><Y><F><Q><K><R><R><A><L><A><Q><G><L><S><T><T><G><T><G><F><G><T><F><L><M><T><V><L><L><K><Y><L><C><A><E><Y><G><W><R><N><A><M><L><I><Q><G><A><V><S><L><N><L><C><V><C><G><A><L><M><R><P><L><S><P><G><K><N><P><N><D><P><G><E><K><D><V><R><G><L><P><A><H><S><T><E><S><V><K><S><T><G><Q><Q><G><R><T><E><E><K><D><G><G><L><G><N><E><E><T><L><C><D><L><Q><A><Q><E><C><P><D><Q><A><G><H><R><K><N><M><C><A><L><R><I><L><K><T><V><S><W><L><T><M><R><V><R><K><G><F><E><D><W><Y><S><G><Y><F><G><T><A><S><L><F><T><N><R><M><F><V><A><F><I><F><W><A><L><F><A><Y><S><S><F><V><I><P><F><I><H><L><P><E><I><V><N><L><Y><N><L><S><E><Q><N><D><V><F><P><L><T><S><I><I><A><I><V><H><I><F><G><K><V><I><L><G><V><I><A><D><L><P><C><I><S><V><W><N><V><F><L><L><A><N><F><T><L><V><L><S><I><F><I><L><P><L><M><H><T><Y><A><G><L><A><V><I><C><A><L><I><G><F><S><S><G><Y><F><S><L><M><P><V><V><T><E><D><L><V><G><I><E><H><L><A><N><A><Y><G><I><I><I><C><A><N><G><I><S><A><L><L><G><P><P><F><A><G><W><I><Y><D><I><T><Q><K><Y><D><F><S><F><Y><I><C><G><L><L><Y><M><I><G><I><L><F><L><L><I><Q><P><C><I><R><I><I><E><Q><S><R><R><K><Y><M><D><G><A><H><V> | Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.<BOP> | Q7RTX9 |
P23284 | PPIB_HUMAN | S-cyclophilin | Homo | <M><L><R><L><S><E><R><N><M><K><V><L><L><A><A><A><L><I><A><G><S><V><F><F><L><L><L><P><G><P><S><A><A><D><E><K><K><K><G><P><K><V><T><V><K><V><Y><F><D><L><R><I><G><D><E><D><V><G><R><V><I><F><G><L><F><G><K><T><V><P><K><T><V><D><N><F><V><A><L><A><T><G><E><K><G><F><G><Y><K><N><S><K><F><H><R><V><I><K><D><F><M><I><Q><G><G><D><F><T><R><G><D><G><T><G><G><K><S><I><Y><G><E><R><F><P><D><E><N><F><K><L><K><H><Y><G><P><G><W><V><S><M><A><N><A><G><K><D><T><N><G><S><Q><F><F><I><T><T><V><K><T><A><W><L><D><G><K><H><V><V><F><G><K><V><L><E><G><M><E><V><V><R><K><V><E><S><T><K><T><D><S><R><D><K><P><L><K><D><V><I><I><A><D><C><G><K><I><E><V><E><K><P><F><A><I><A><K><E> | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.<BOP> | P23284 |
P48304 | REG1B_HUMAN | Regenerating protein I beta | Homo | <M><A><Q><T><N><S><F><F><M><L><I><S><S><L><M><F><L><S><L><S><Q><G><Q><E><S><Q><T><E><L><P><N><P><R><I><S><C><P><E><G><T><N><A><Y><R><S><Y><C><Y><Y><F><N><E><D><P><E><T><W><V><D><A><D><L><Y><C><Q><N><M><N><S><G><N><L><V><S><V><L><T><Q><A><E><G><A><F><V><A><S><L><I><K><E><S><S><T><D><D><S><N><V><W><I><G><L><H><D><P><K><K><N><R><R><W><H><W><S><S><G><S><L><V><S><Y><K><S><W><D><T><G><S><P><S><S><A><N><A><G><Y><C><A><S><L><T><S><C><S><G><F><K><K><W><K><D><E><S><C><E><K><K><F><S><F><V><C><K><F><K><N> | Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.<BOP> | P48304 |
P05093 | CP17A_HUMAN | Steroid 17-alpha-monooxygenase | Homo | <M><W><E><L><V><A><L><L><L><L><T><L><A><Y><L><F><W><P><K><R><R><C><P><G><A><K><Y><P><K><S><L><L><S><L><P><L><V><G><S><L><P><F><L><P><R><H><G><H><M><H><N><N><F><F><K><L><Q><K><K><Y><G><P><I><Y><S><V><R><M><G><T><K><T><T><V><I><V><G><H><H><Q><L><A><K><E><V><L><I><K><K><G><K><D><F><S><G><R><P><Q><M><A><T><L><D><I><A><S><N><N><R><K><G><I><A><F><A><D><S><G><A><H><W><Q><L><H><R><R><L><A><M><A><T><F><A><L><F><K><D><G><D><Q><K><L><E><K><I><I><C><Q><E><I><S><T><L><C><D><M><L><A><T><H><N><G><Q><S><I><D><I><S><F><P><V><F><V><A><V><T><N><V><I><S><L><I><C><F><N><T><S><Y><K><N><G><D><P><E><L><N><V><I><Q><N><Y><N><E><G><I><I><D><N><L><S><K><D><S><L><V><D><L><V><P><W><L><K><I><F><P><N><K><T><L><E><K><L><K><S><H><V><K><I><R><N><D><L><L><N><K><I><L><E><N><Y><K><E><K><F><R><S><D><S><I><T><N><M><L><D><T><L><M><Q><A><K><M><N><S><D><N><G><N><A><G><P><D><Q><D><S><E><L><L><S><D><N><H><I><L><T><T><I><G><D><I><F><G><A><G><V><E><T><T><T><S><V><V><K><W><T><L><A><F><L><L><H><N><P><Q><V><K><K><K><L><Y><E><E><I><D><Q><N><V><G><F><S><R><T><P><T><I><S><D><R><N><R><L><L><L><L><E><A><T><I><R><E><V><L><R><L><R><P><V><A><P><M><L><I><P><H><K><A><N><V><D><S><S><I><G><E><F><A><V><D><K><G><T><E><V><I><I><N><L><W><A><L><H><H><N><E><K><E><W><H><Q><P><D><Q><F><M><P><E><R><F><L><N><P><A><G><T><Q><L><I><S><P><S><V><S><Y><L><P><F><G><A><G><P><R><S><C><I><G><E><I><L><A><R><Q><E><L><F><L><I><M><A><W><L><L><Q><R><F><D><L><E><V><P><D><D><G><Q><L><P><S><L><E><G><I><P><K><V><V><F><L><I><D><S><F><K><V><K><I><K><V><R><Q><A><W><R><E><A><Q><A><E><G><S><T> | A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis . Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione . Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis . Mechanistically, uses molecular oxygen inserting one oxygen atom into a | P05093 |
Q02577 | HEN2_HUMAN | Nescient helix loop helix 2 | Homo | <M><M><L><S><P><D><Q><A><A><D><S><D><H><P><S><S><A><H><S><D><P><E><S><L><G><G><T><D><T><K><V><L><G><S><V><S><D><L><E><P><V><E><E><A><E><G><D><G><K><G><G><S><R><A><A><L><Y><P><H><P><Q><Q><L><S><R><E><E><K><R><R><R><R><R><A><T><A><K><Y><R><S><A><H><A><T><R><E><R><I><R><V><E><A><F><N><L><A><F><A><E><L><R><K><L><L><P><T><L><P><P><D><K><K><L><S><K><I><E><I><L><R><L><A><I><C><Y><I><S><Y><L><N><H><V><L><D><V> | Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3'. Involved in regulating energy expenditure, body mass, voluntary physical activity, mating behavior and reproductive longevity, acting through the hypothalamic-pituitary-gonadal axis. Acts as a transcriptional activator of target genes, including NDN and PCSK1. May act centrally to regulate function of both white and brown adipose tissue. Together with NHLH1, required to maintain migration and survival of cells in the anterior extramural migration stream (aes), which forms the precerebellar nuclei. Also, in concert with NHLH1, may determine fate of gonadotropin releasing hormone-1 (GnRH-1) neurons.<BOP> | Q02577 |
Q01105 | SET_HUMAN | Template-activating factor I | Homo | <M><A><P><K><R><Q><S><P><L><P><P><Q><K><K><K><P><R><P><P><P><A><L><G><P><E><E><T><S><A><S><A><G><L><P><K><K><G><E><K><E><Q><Q><E><A><I><E><H><I><D><E><V><Q><N><E><I><D><R><L><N><E><Q><A><S><E><E><I><L><K><V><E><Q><K><Y><N><K><L><R><Q><P><F><F><Q><K><R><S><E><L><I><A><K><I><P><N><F><W><V><T><T><F><V><N><H><P><Q><V><S><A><L><L><G><E><E><D><E><E><A><L><H><Y><L><T><R><V><E><V><T><E><F><E><D><I><K><S><G><Y><R><I><D><F><Y><F><D><E><N><P><Y><F><E><N><K><V><L><S><K><E><F><H><L><N><E><S><G><D><P><S><S><K><S><T><E><I><K><W><K><S><G><K><D><L><T><K><R><S><S><Q><T><Q><N><K><A><S><R><K><R><Q><H><E><E><P><E><S><F><F><T><W><F><T><D><H><S><D><A><G><A><D><E><L><G><E><V><I><K><D><D><I><W><P><N><P><L><Q><Y><Y><L><V><P><D><M><D><D><E><E><G><E><G><E><E><D><D><D><D><D><E><E><E><E><G><L><E><D><I><D><E><E><G><D><E><D><E><G><E><E><D><E><D><D><D><E><G><E><E><G><E><E><D><E><G><E><D><D> | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.<BOP> | Q01105 |
Q7Z4R8 | CF120_HUMAN | UPF0669 protein C6orf120 | Homo | <M><A><A><P><R><G><R><A><A><P><W><T><T><A><L><L><L><L><L><A><S><Q><V><L><S><P><G><S><C><A><D><E><E><E><V><P><E><E><W><V><L><L><H><V><V><Q><G><Q><I><G><A><G><N><Y><S><Y><L><R><L><N><H><E><G><K><I><V><L><R><M><R><S><L><K><G><D><A><D><L><Y><V><S><A><S><S><L><H><P><S><F><D><D><Y><E><L><Q><S><A><T><C><G><P><D><A><V><S><I><P><A><H><F><R><R><P><V><G><I><G><V><Y><G><H><P><S><H><L><E><S><E><F><E><M><K><V><Y><Y><D><G><T><V><E><Q><H><P><F><G><E><A><A><Y><P><A><D><G><A><D><A><G><Q><K><H><A><G><A><P><E><D><A><S><Q><E><E><E><S><V><L><W><T><I><L><I><S><I><L><K><L><V><L><E><I><L><F> | May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.<BOP> | Q7Z4R8 |
Q6ZMS4 | ZN852_HUMAN | Zinc finger protein 852 | Homo | <M><V><R><P><Q><D><T><V><A><Y><E><D><L><S><E><D><Y><T><Q><K><K><W><K><G><L><A><L><S><Q><R><A><L><H><W><N><M><M><L><E><N><D><R><S><M><A><S><L><G><R><N><M><M><E><S><S><E><L><T><P><K><Q><E><I><F><K><G><S><E><S><S><N><S><T><S><G><G><L><F><G><V><V><P><G><G><T><E><T><G><D><V><C><E><D><T><F><K><E><L><E><G><Q><P><S><N><E><E><G><S><R><L><E><S><D><F><L><E><I><I><D><E><D><K><K><K><S><T><K><D><R><Y><E><E><Y><K><E><V><E><E><H><P><P><L><S><S><S><P><V><E><H><E><G><V><L><K><G><Q><K><S><Y><R><C><D><E><C><G><K><A><F><Y><W><S><S><H><L><I><G><H><R><R><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><T><F><R><Q><T><S><Q><L><I><V><H><L><R><T><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><A><Y><R><H><S><S><H><L><I><Q><H><Q><R><L><H><N><G><E><K><P><Y><K><C><N><E><C><A><K><A><F><N><Q><S><S><K><L><F><D><H><Q><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><A><A><F><S><R><S><K><N><L><V><R><H><Q><F><L><H><T><G><K><K><P><Y><K><C><N><E><C><G><R><A><F><C><S><N><R><N><L><I><D><H><Q><R><T><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><S><R><S><K><C><L><I><R><H><Q><S><L><H><T><G><E><K><P><Y><K><C><S><E><C><G><K><A><F><N><Q><I><S><Q><L><V><E><H><E><R><I><H><T><G><E><K><P><F><K><C><S><E><C><G><K><A><F><G><L><S><K><C><L><I><R><H><Q><R><L><H><T><S><E><K><P><Y><K><C><N><E><C><G><K><S><F><N><Q><N><S><Y><L><I><I><H><Q><R><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><V><F><S><Y><N><S><S><L><M><V><H><Q><R><T><H><T><G><E><K><P><Y><K><C><N><S><C><G><K><A><F><S><D><S><S><Q><L><T><V><H><Q><R><V><H><T><G><E><K><N><L><M><N><V><L><S><V><G><K><P><L><V><S><V><P><L><L><I><T><T><S><E><L><M><L><E><R><S><P><Q><V><W><L><G><H><L><L><K><A><W><F><S><E><T><D><S><K><D><L> | May be involved in transcriptional regulation.<BOP> | Q6ZMS4 |
Q8N328 | PGBD3_HUMAN | PiggyBac transposable element-derived protein 3 | Homo | <M><P><R><T><L><S><L><H><E><I><T><D><L><L><E><T><D><D><S><I><E><A><S><A><I><V><I><Q><P><P><E><N><A><T><A><P><V><S><D><E><E><S><G><D><E><E><G><G><T><I><N><N><L><P><G><S><L><L><H><T><A><A><Y><L><I><Q><D><G><S><D><A><E><S><D><S><D><D><P><S><Y><A><P><K><D><D><S><P><D><E><V><P><S><T><F><T><V><Q><Q><P><P><P><S><R><R><R><K><M><T><K><I><L><C><K><W><K><K><A><D><L><T><V><Q><P><V><A><G><R><V><T><A><P><P><N><D><F><F><T><V><M><R><T><P><T><E><I><L><E><L><F><L><D><D><E><V><I><E><L><I><V><K><Y><S><N><L><Y><A><C><S><K><G><V><H><L><G><L><T><S><S><E><F><K><C><F><L><G><I><I><F><L><S><G><Y><V><S><V><P><R><R><R><M><F><W><E><Q><R><T><D><V><H><N><V><L><V><S><A><A><M><R><R><D><R><F><E><T><I><F><S><N><L><H><V><A><D><N><A><N><L><D><P><V><D><K><F><S><K><L><R><P><L><I><S><K><L><N><E><R><C><M><K><F><V><P><N><E><T><Y><F><S><F><D><E><F><M><V><P><Y><F><G><R><H><G><C><K><Q><F><I><R><G><K><P><I><R><F><G><Y><K><F><W><C><G><A><T><C><L><G><Y><I><C><W><F><Q><P><Y><Q><G><K><N><P><N><T><K><H><E><E><Y><G><V><G><A><S><L><V><L><Q><F><S><E><A><L><T><E><A><H><P><G><Q><Y><H><F><V><F><N><N><F><F><T><S><I><A><L><L><D><K><L><S><S><M><G><H><Q><A><T><G><T><V><R><K><D><H><I><D><R><V><P><L><E><S><D><V><A><L><K><K><K><E><R><G><T><F><D><Y><R><I><D><G><K><G><N><I><V><C><R><W><N><D><N><S><V><V><T><V><A><S><S><G><A><G><I><H><P><L><C><L><V><S><R><Y><S><Q><K><L><K><K><K><I><Q><V><Q><Q><P><N><M><I><K><V><Y><N><Q><F><M><G><G><V><D><R><A><D><E><N><I><D><K><Y><R><A><S><I><R><G><K><K><W><Y><S><S><P><L><L><F><C><F><E><L><V><L><Q><N><A><W><Q><L><H><K><T><Y><D><E><K><P><V><D><F><L><E><F><R><R><R><V><V><C><H><Y><L><E><T><H><G><H><P><P><E><P><G><Q><K><G><R><P><Q><K><R><N><I><D><S><R><Y><D><G><I><N><H><V><I><V><K><Q><G><K><Q><T><R><C><A><E><C><H><K><N><T><T><F><R><C><E><K><C><D><V><A><L><H><V><K><C><S><V><E><Y><H><T><E> | Binds in vitro to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF.<BOP> | Q8N328 |
Q9HB07 | MYG1_HUMAN | MYG1 exonuclease | Homo | <M><G><H><R><F><L><R><G><L><L><T><L><L><L><P><P><P><P><L><Y><T><R><H><R><M><L><G><P><E><S><V><P><P><P><K><R><S><R><S><K><L><M><A><P><P><R><I><G><T><H><N><G><T><F><H><C><D><E><A><L><A><C><A><L><L><R><L><L><P><E><Y><R><D><A><E><I><V><R><T><R><D><P><E><K><L><A><S><C><D><I><V><V><D><V><G><G><E><Y><D><P><R><R><H><R><Y><D><H><H><Q><R><S><F><T><E><T><M><S><S><L><S><P><G><K><P><W><Q><T><K><L><S><S><A><G><L><I><Y><L><H><F><G><H><K><L><L><A><Q><L><L><G><T><S><E><E><D><S><M><V><G><T><L><Y><D><K><M><Y><E><N><F><V><E><E><V><D><A><V><D><N><G><I><S><Q><W><A><E><G><E><P><R><Y><A><L><T><T><T><L><S><A><R><V><A><R><L><N><P><T><W><N><H><P><D><Q><D><T><E><A><G><F><K><R><A><M><D><L><V><Q><E><E><F><L><Q><R><L><D><F><Y><Q><H><S><W><L><P><A><R><A><L><V><E><E><A><L><A><Q><R><F><Q><V><D><P><S><G><E><I><V><E><L><A><K><G><A><C><P><W><K><E><H><L><Y><H><L><E><S><G><L><S><P><P><V><A><I><F><F><V><I><Y><T><D><Q><A><G><Q><W><R><I><Q><C><V><P><K><E><P><H><S><F><Q><S><R><L><P><L><P><E><P><W><R><G><L><R><D><E><A><L><D><Q><V><S><G><I><P><G><C><I><F><V><H><A><S><G><F><T><G><G><H><H><T><R><E><G><A><L><S><M><A><R><A><T><L><A><Q><R><S><Y><L><P><Q><I><S> | 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk . In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable).<BOP> | Q9HB07 |
Q86X24 | HORM1_HUMAN | Newborn ovary HORMA protein | Homo | <M><A><T><A><Q><L><Q><R><T><P><M><S><A><L><V><F><P><N><K><I><S><T><E><H><Q><S><L><V><L><V><K><R><L><L><A><V><S><V><S><C><I><T><Y><L><R><G><I><F><P><E><C><A><Y><G><T><R><Y><L><D><D><L><C><V><K><I><L><R><E><D><K><N><C><P><G><S><T><Q><L><V><K><W><M><L><G><C><Y><D><A><L><Q><K><K><Y><L><R><M><V><V><L><A><V><Y><T><N><P><E><D><P><Q><T><I><S><E><C><Y><Q><F><K><F><K><Y><T><N><N><G><P><L><M><D><F><I><S><K><N><Q><S><N><E><S><S><M><L><S><T><D><T><K><K><A><S><I><L><L><I><R><K><I><Y><I><L><M><Q><N><L><G><P><L><P><N><D><V><C><L><T><M><K><L><F><Y><Y><D><E><V><T><P><P><D><Y><Q><P><P><G><F><K><D><G><D><C><E><G><V><I><F><E><G><E><P><M><Y><L><N><V><G><E><V><S><T><P><F><H><I><F><K><V><K><V><T><T><E><R><E><R><M><E><N><I><D><S><T><I><L><S><P><K><Q><I><K><T><P><F><Q><K><I><L><R><D><K><D><V><E><D><E><Q><E><H><Y><T><S><D><D><L><D><I><E><T><K><M><E><E><Q><E><K><N><P><A><S><S><E><L><E><E><P><S><L><V><C><E><E><D><E><I><M><R><S><K><E><S><P><D><L><S><I><S><H><S><Q><V><E><Q><L><V><N><K><T><S><E><L><D><M><S><E><S><K><T><R><S><G><K><V><F><Q><N><K><M><A><N><G><N><Q><P><V><K><S><S><K><E><N><R><K><R><S><Q><H><E><S><G><R><I><V><L><H><H><F><D><S><S><S><Q><E><S><V><P><K><R><R><K><F><S><E><P><K><E><H><I> | Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.<BOP> | Q86X24 |
Q9Y276 | BCS1_HUMAN | BCS1-like protein | Homo | <M><P><L><S><D><F><I><L><A><L><K><D><N><P><Y><F><G><A><G><F><G><L><V><G><V><G><T><A><L><A><L><A><R><K><G><V><Q><L><G><L><V><A><F><R><R><H><Y><M><I><T><L><E><V><P><A><R><D><R><S><Y><A><W><L><L><S><W><L><T><R><H><S><T><R><T><Q><H><L><S><V><E><T><S><Y><L><Q><H><E><S><G><R><I><S><T><K><F><E><F><V><P><S><P><G><N><H><F><I><W><Y><R><G><K><W><I><R><V><E><R><S><R><E><M><Q><M><I><D><L><Q><T><G><T><P><W><E><S><V><T><F><T><A><L><G><T><D><R><K><V><F><F><N><I><L><E><E><A><R><E><L><A><L><Q><Q><E><E><G><K><T><V><M><Y><T><A><V><G><S><E><W><R><P><F><G><Y><P><R><R><R><R><P><L><N><S><V><V><L><Q><Q><G><L><A><D><R><I><V><R><D><V><Q><E><F><I><D><N><P><K><W><Y><T><D><R><G><I><P><Y><R><R><G><Y><L><L><Y><G><P><P><G><C><G><K><S><S><F><I><T><A><L><A><G><E><L><E><H><S><I><C><L><L><S><L><T><D><S><S><L><S><D><D><R><L><N><H><L><L><S><V><A><P><Q><Q><S><L><V><L><L><E><D><V><D><A><A><F><L><S><R><D><L><A><V><E><N><P><V><K><Y><Q><G><L><G><R><L><T><F><S><G><L><L><N><A><L><D><G><V><A><S><T><E><A><R><I><V><F><M><T><T><N><H><V><D><R><L><D><P><A><L><I><R><P><G><R><V><D><L><K><E><Y><V><G><Y><C><S><H><W><Q><L><T><Q><M><F><Q><R><F><Y><P><G><Q><A><P><S><L><A><E><N><F><A><E><H><V><L><R><A><T><N><Q><I><S><P><A><Q><V><Q><G><Y><F><M><L><Y><K><N><D><P><V><G><A><I><H><N><A><E><S><L><R><R> | Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex.<BOP> | Q9Y276 |
Q9UF12 | HYPDH_HUMAN | Probable proline oxidase 2 | Homo | <M><S><P><R><V><V><S><N><S><S><V><L><A><S><Q><S><V><G><I><T><N><V><R><T><V><F><S><N><V><F><N><N><T><T><A><F><P><I><L><R><G><S><N><C><H><K><I><T><A><P><G><L><G><K><G><Q><L><V><N><L><L><P><P><E><N><L><P><W><C><G><G><S><Q><G><P><R><M><L><R><T><C><Y><V><L><C><S><Q><A><G><P><P><S><R><G><W><Q><S><L><S><F><D><G><G><A><F><H><L><K><G><T><G><E><L><T><R><A><L><L><V><L><R><L><C><A><W><P><P><L><V><T><H><G><L><L><L><Q><A><W><S><R><R><L><L><G><S><R><L><S><G><A><F><L><R><A><S><V><Y><G><Q><F><V><A><G><E><T><A><E><E><V><K><G><C><V><Q><Q><L><R><T><L><S><L><R><P><L><L><A><V><P><T><E><E><E><P><D><S><A><A><K><S><G><E><A><W><Y><E><G><N><L><G><A><M><L><R><C><V><D><L><S><R><G><L><L><E><P><P><S><L><A><E><A><S><L><M><Q><L><K><V><T><A><L><T><S><T><R><L><C><K><E><L><A><S><W><V><R><R><P><G><A><S><L><E><L><S><P><E><R><L><A><E><A><M><D><S><G><Q><N><L><Q><V><S><C><L><N><A><E><Q><N><Q><H><L><R><A><S><L><S><R><L><H><R><V><A><Q><Y><A><R><A><Q><H><V><R><L><L><V><D><A><E><Y><T><S><L><N><P><A><L><S><L><L><V><A><A><L><A><V><R><W><N><S><P><G><E><G><G><P><W><V><W><N><T><Y><Q><A><C><L><K><D><T><F><E><R><L><G><R><D><A><E><A><A><H><R><A><G><L><A><F><G><V><K><L><V><R><G><A><Y><L><D><K><E><R><A><V><A><Q><L><H><G><M><E><D><P><T><Q><P><D><Y><E><A><T><S><Q><S><Y><S><R><C><L><E><L><M><L><T><H><V><A><R><H><G><P><M><C><H><L><M><V><A><S><H><N><E><E><S><V><R><Q><A><T><K><R><M><W><E><L><G><I><P><L><D><G><T><V><C><F><G><Q><L><L><G><M><C><D><H><V><S><L><A><L><G><Q><A><G><Y><V><V><Y><K><S><I><P><Y><G><S><L><E><E><V><I><P><Y><L><I><R><R><A><Q><E><N><R><S><V><L><Q><G><A><R><R><E><Q><E><L><L><S><Q><E><L><W><R><R><L><L><P><G><C><R><R><I><P><H> | Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.<BOP> | Q9UF12 |
Q5VUJ6 | LRCH2_HUMAN | Leucine-rich repeat and calponin homology domain-containing protein 2 | Homo | <M><A><A><S><Q><G><G><G><G><N><S><G><G><G><G><C><G><G><G><G><S><S><G><G><C><G><T><A><G><G><G><G><G><G><A><G><G><G><G><G><G><G><G><G><T><L><V><V><P><I><P><V><P><T><L><F><G><Q><P><F><P><N><G><P><P><W><N><P><G><S><L><Q><P><Q><H><T><V><R><S><L><D><R><A><L><E><E><A><G><S><S><G><I><L><S><L><S><G><R><K><L><R><D><F><P><G><S><G><Y><D><L><T><D><T><T><Q><A><D><L><S><R><N><R><F><T><E><I><P><S><D><V><W><L><F><A><P><L><E><T><L><N><L><Y><H><N><C><I><K><T><I><P><E><A><I><K><N><L><Q><M><L><T><Y><L><N><I><S><R><N><L><L><S><T><L><P><K><Y><L><F><D><L><P><L><K><V><L><V><V><S><N><N><K><L><V><S><I><P><E><E><I><G><K><L><K><D><L><M><E><L><D><I><S><C><N><E><I><Q><V><L><P><Q><Q><M><G><K><L><H><S><L><R><E><L><N><I><R><R><N><N><L><H><V><L><P><D><E><L><G><D><L><P><L><V><K><L><D><F><S><C><N><K><V><T><E><I><P><V><C><Y><R><K><L><H><H><L><Q><V><I><I><L><D><N><N><P><L><Q><V><P><P><A><Q><I><C><L><K><G><K><V><H><I><F><K><Y><L><N><I><Q><A><C><C><R><M><D><K><K><P><D><S><L><D><L><P><S><L><S><K><R><M><P><S><Q><P><L><T><D><S><M><E><D><F><Y><P><N><K><N><H><G><P><D><S><G><I><G><S><D><N><G><E><K><R><L><S><T><T><E><P><S><D><D><D><T><V><S><L><H><S><Q><V><S><E><S><N><R><E><Q><T><S><R><N><D><S><H><I><I><G><S><K><T><D><S><Q><K><D><Q><E><V><Y><D><F><V><D><P><N><T><E><D><V><A><V><P><E><Q><G><N><A><H><I><G><S><F><V><S><F><F><K><G><K><E><K><C><S><E><K><S><R><K><N><E><E><L><G><D><E><K><R><L><E><K><E><Q><L><L><A><E><E><E><D><D><D><L><K><E><V><T><D><L><R><K><I><A><A><Q><L><L><Q><Q><E><Q><K><N><R><I><L><N><H><S><T><S><V><M><R><N><K><P><K><Q><T><V><E><C><E><K><S><V><S><A><D><E><V><N><S><P><L><S><P><L><T><W><Q><P><L><E><N><Q><K><D><Q><I><D><E><Q><P><W><P><E><S><H><P><I><I><W><Q><S><E><E><R><R><R><S><K><Q><I><R><K><E><Y><F><K><Y><K><S><M><R><K><S><S><S><G><N><E><N><D><E><Q><D><S><D><N><A><N><M><S><T><Q><S><P><V><S><S><E><E><Y><D><R><T><D><G><F><S><H><S><P><F><G><L><K><P><R><S><A><F><S><R><S><S><R><Q><E><Y><G><A><A><D><P><G><F><T><M><R><R><K><M><E><H><L><R><E><E><R><E><Q><I><R><Q><L><R><N><N><L><E><S><R><L><K><V><I><L><P><D><D><I><G><A><A><L><M><D><G><V><V><L><C><H><L><A><N><H><I><R><P><R><S><V><A><S><I><H><V><P><S><P><A><V><P><K><L><S><M><A><K><C><R><R><N><V><E><N><F><L><D><A><C><K><K><L><G><V><S><Q><E><R><L><C><L><P><H><H><I><L><E><E><R><G><L><V><K><V><G><V><T><V><Q><A><L><L><E><L><P><T><T><K><A><S><Q><L><S><V><A> | May play a role in the organization of the cytoskeleton.<BOP> | Q5VUJ6 |
P02760 | AMBP_HUMAN | Trypstatin | Homo | <M><R><S><L><G><A><L><L><L><L><L><S><A><C><L><A><V><S><A><G><P><V><P><T><P><P><D><N><I><Q><V><Q><E><N><F><N><I><S><R><I><Y><G><K><W><Y><N><L><A><I><G><S><T><C><P><W><L><K><K><I><M><D><R><M><T><V><S><T><L><V><L><G><E><G><A><T><E><A><E><I><S><M><T><S><T><R><W><R><K><G><V><C><E><E><T><S><G><A><Y><E><K><T><D><T><D><G><K><F><L><Y><H><K><S><K><W><N><I><T><M><E><S><Y><V><V><H><T><N><Y><D><E><Y><A><I><F><L><T><K><K><F><S><R><H><H><G><P><T><I><T><A><K><L><Y><G><R><A><P><Q><L><R><E><T><L><L><Q><D><F><R><V><V><A><Q><G><V><G><I><P><E><D><S><I><F><T><M><A><D><R><G><E><C><V><P><G><E><Q><E><P><E><P><I><L><I><P><R><V><R><R><A><V><L><P><Q><E><E><E><G><S><G><G><G><Q><L><V><T><E><V><T><K><K><E><D><S><C><Q><L><G><Y><S><A><G><P><C><M><G><M><T><S><R><Y><F><Y><N><G><T><S><M><A><C><E><T><F><Q><Y><G><G><C><M><G><N><G><N><N><F><V><T><E><K><E><C><L><Q><T><C><R><T><V><A><A><C><N><L><P><I><V><R><G><P><C><R><A><F><I><Q><L><W><A><F><D><A><V><K><G><K><C><V><L><F><P><Y><G><G><C><Q><G><N><G><N><K><F><Y><S><E><K><E><C><R><E><Y><C><G><V><P><G><D><G><D><E><E><L><L><R><F><S><N> | Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.<BOP> | P02760 |
Q04864 | REL_HUMAN | Proto-oncogene c-Rel | Homo | <M><A><S><G><A><Y><N><P><Y><I><E><I><I><E><Q><P><R><Q><R><G><M><R><F><R><Y><K><C><E><G><R><S><A><G><S><I><P><G><E><H><S><T><D><N><N><R><T><Y><P><S><I><Q><I><M><N><Y><Y><G><K><G><K><V><R><I><T><L><V><T><K><N><D><P><Y><K><P><H><P><H><D><L><V><G><K><D><C><R><D><G><Y><Y><E><A><E><F><G><Q><E><R><R><P><L><F><F><Q><N><L><G><I><R><C><V><K><K><K><E><V><K><E><A><I><I><T><R><I><K><A><G><I><N><P><F><N><V><P><E><K><Q><L><N><D><I><E><D><C><D><L><N><V><V><R><L><C><F><Q><V><F><L><P><D><E><H><G><N><L><T><T><A><L><P><P><V><V><S><N><P><I><Y><D><N><R><A><P><N><T><A><E><L><R><I><C><R><V><N><K><N><C><G><S><V><R><G><G><D><E><I><F><L><L><C><D><K><V><Q><K><D><D><I><E><V><R><F><V><L><N><D><W><E><A><K><G><I><F><S><Q><A><D><V><H><R><Q><V><A><I><V><F><K><T><P><P><Y><C><K><A><I><T><E><P><V><T><V><K><M><Q><L><R><R><P><S><D><Q><E><V><S><E><S><M><D><F><R><Y><L><P><D><E><K><D><T><Y><G><N><K><A><K><K><Q><K><T><T><L><L><F><Q><K><L><C><Q><D><H><V><E><T><G><F><R><H><V><D><Q><D><G><L><E><L><L><T><S><G><D><P><P><T><L><A><S><Q><S><A><G><I><T><V><N><F><P><E><R><P><R><P><G><L><L><G><S><I><G><E><G><R><Y><F><K><K><E><P><N><L><F><S><H><D><A><V><V><R><E><M><P><T><G><V><S><S><Q><A><E><S><Y><Y><P><S><P><G><P><I><S><S><G><L><S><H><H><A><S><M><A><P><L><P><S><S><S><W><S><S><V><A><H><P><T><P><R><S><G><N><T><N><P><L><S><S><F><S><T><R><T><L><P><S><N><S><Q><G><I><P><P><F><L><R><I><P><V><G><N><D><L><N><A><S><N><A><C><I><Y><N><N><A><D><D><I><V><G><M><E><A><S><S><M><P><S><A><D><L><Y><G><I><S><D><P><N><M><L><S><N><C><S><V><N><M><M><T><T><S><S><D><S><M><G><E><T><D><N><P><R><L><L><S><M><N><L><E><N><P><S><C><N><S><V><L><D><P><R><D><L><R><Q><L><H><Q><M><S><S><S><S><M><S><A><G><A><N><S><N><T><T><V><F><V><S><Q><S><D><A><F><E><G><S><D><F><S><C><A><D><N><S><M><I><N><E><S><G><P><S><N><S><T><N><P><N><S><H><G><F><V><Q><D><S><Q><Y><S><G><I><G><S><M><Q><N><E><Q><L><S><D><S><F><P><Y><E><F><F><Q><V> | Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B | Q04864 |
Q8N5S9 | KKCC1_HUMAN | Calcium/calmodulin-dependent protein kinase kinase alpha | Homo | <M><E><G><G><P><A><V><C><C><Q><D><P><R><A><E><L><V><E><R><V><A><A><I><D><V><T><H><L><E><E><A><D><G><G><P><E><P><T><R><N><G><V><D><P><P><P><R><A><R><A><A><S><V><I><P><G><S><T><S><R><L><L><P><A><R><P><S><L><S><A><R><K><L><S><L><Q><E><R><P><A><G><S><Y><L><E><A><Q><A><G><P><Y><A><T><G><P><A><S><H><I><S><P><R><A><W><R><R><P><T><I><E><S><H><H><V><A><I><S><D><A><E><D><C><V><Q><L><N><Q><Y><K><L><Q><S><E><I><G><K><G><A><Y><G><V><V><R><L><A><Y><N><E><S><E><D><R><H><Y><A><M><K><V><L><S><K><K><K><L><L><K><Q><Y><G><F><P><R><R><P><P><P><R><G><S><Q><A><A><Q><G><G><P><A><K><Q><L><L><P><L><E><R><V><Y><Q><E><I><A><I><L><K><K><L><D><H><V><N><V><V><K><L><I><E><V><L><D><D><P><A><E><D><N><L><Y><L><V><F><D><L><L><R><K><G><P><V><M><E><V><P><C><D><K><P><F><S><E><E><Q><A><R><L><Y><L><R><D><V><I><L><G><L><E><Y><L><H><C><Q><K><I><V><H><R><D><I><K><P><S><N><L><L><L><G><D><D><G><H><V><K><I><A><D><F><G><V><S><N><Q><F><E><G><N><D><A><Q><L><S><S><T><A><G><T><P><A><F><M><A><P><E><A><I><S><D><S><G><Q><S><F><S><G><K><A><L><D><V><W><A><T><G><V><T><L><Y><C><F><V><Y><G><K><C><P><F><I><D><D><F><I><L><A><L><H><R><K><I><K><N><E><P><V><V><F><P><E><E><P><E><I><S><E><E><L><K><D><L><I><L><K><M><L><D><K><N><P><E><T><R><I><G><V><P><D><I><K><L><H><P><W><V><T><K><N><G><E><E><P><L><P><S><E><E><E><H><C><S><V><V><E><V><T><E><E><E><V><K><N><S><V><R><L><I><P><S><W><T><T><V><I><L><V><K><S><M><L><R><K><R><S><F><G><N><P><F><E><P><Q><A><R><R><E><E><R><S><M><S><A><P><G><N><L><L><V><K><E><G><F><G><E><G><G><K><S><P><E><L><P><G><V><Q><E><D><E><A><A><S> | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.<BOP> | Q8N5S9 |
Q8TBZ3 | WDR20_HUMAN | Protein DMR | Homo | <M><A><T><E><G><G><G><K><E><M><N><E><I><K><T><Q><F><T><T><R><E><G><L><Y><K><L><L><P><H><S><E><Y><S><R><P><N><R><V><P><F><N><S><Q><G><S><N><P><V><R><V><S><F><V><N><L><N><D><Q><S><G><N><G><D><R><L><C><F><N><V><G><R><E><L><Y><F><Y><I><Y><K><G><V><R><K><A><A><D><L><S><K><P><I><D><K><R><I><Y><K><G><T><Q><P><T><C><H><D><F><N><H><L><T><A><T><A><E><S><V><S><L><L><V><G><F><S><A><G><Q><V><Q><L><I><D><P><I><K><K><E><T><S><K><L><F><N><E><E><R><L><I><D><K><S><R><V><T><C><V><K><W><V><P><G><S><E><S><L><F><L><V><A><H><S><S><G><N><M><Y><L><Y><N><V><E><H><T><C><G><T><T><A><P><H><Y><Q><L><L><K><Q><G><E><S><F><A><V><H><T><C><K><S><K><S><T><R><N><P><L><L><K><W><T><V><G><E><G><A><L><N><E><F><A><F><S><P><D><G><K><F><L><A><C><V><S><Q><D><G><F><L><R><V><F><N><F><D><S><V><E><L><H><G><T><M><K><S><Y><F><G><G><L><L><C><V><C><W><S><P><D><G><K><Y><I><V><T><G><G><E><D><D><L><V><T><V><W><S><F><V><D><C><R><V><I><A><R><G><H><G><H><K><S><W><V><S><V><V><A><F><D><P><Y><T><T><S><V><E><E><G><D><P><M><E><F><S><G><S><D><E><D><F><Q><D><L><L><H><F><G><R><D><R><A><N><S><T><Q><S><R><L><S><K><R><N><S><T><D><S><R><P><V><S><V><T><Y><R><F><G><S><V><G><Q><D><T><Q><L><C><L><W><D><L><T><E><D><I><L><F><P><H><Q><P><L><S><R><A><R><T><H><T><N><V><M><N><A><T><S><P><P><A><G><S><N><G><N><S><V><T><T><P><G><N><S><V><P><P><P><L><P><R><S><N><S><L><P><H><S><A><V><S><N><A><G><S><K><S><S><V><M><D><G><A><I><A><S><G><V><S><K><F><A><T><L><S><L><H><D><R><K><E><R><H><H><E><K><D><H><K><R><N><H><S><M><G><H><I><S><S><K><S><S><D><K><L><N><L><V><T><K><T><K><T><D><P><A><K><T><L><G><T><P><L><C><P><R><M><E><D><V><P><L><L><E><P><L><I><C><K><K><I><A><H><E><R><L><T><V><L><I><F><L><E><D><C><I><V><T><A><C><Q><E><G><F><I><C><T><W><G><R><P><G><K><V><V><S><F><N><P> | Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 . Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme .<BOP> | Q8TBZ3 |
Q969V5 | MUL1_HUMAN | RING-type E3 ubiquitin transferase NFKB 1 | Homo | <M><E><S><G><G><R><P><S><L><C><Q><F><I><L><L><G><T><T><S><V><V><T><A><A><L><Y><S><V><Y><R><Q><K><A><R><V><S><Q><E><L><K><G><A><K><K><V><H><L><G><E><D><L><K><S><I><L><S><E><A><P><G><K><C><V><P><Y><A><V><I><E><G><A><V><R><S><V><K><E><T><L><N><S><Q><F><V><E><N><C><K><G><V><I><Q><R><L><T><L><Q><E><H><K><M><V><W><N><R><T><T><H><L><W><N><D><C><S><K><I><I><H><Q><R><T><N><T><V><P><F><D><L><V><P><H><E><D><G><V><D><V><A><V><R><V><L><K><P><L><D><S><V><D><L><G><L><E><T><V><Y><E><K><F><H><P><S><I><Q><S><F><T><D><V><I><G><H><Y><I><S><G><E><R><P><K><G><I><Q><E><T><E><E><M><L><K><V><G><A><T><L><T><G><V><G><E><L><V><L><D><N><N><S><V><R><L><Q><P><P><K><Q><G><M><Q><Y><Y><L><S><S><Q><D><F><D><S><L><L><Q><R><Q><E><S><S><V><R><L><W><K><V><L><A><L><V><F><G><F><A><T><C><A><T><L><F><F><I><L><R><K><Q><Y><L><Q><R><Q><E><R><L><R><L><K><Q><M><Q><E><E><F><Q><E><H><E><A><Q><L><L><S><R><A><K><P><E><D><R><E><S><L><K><S><A><C><V><V><C><L><S><S><F><K><S><C><V><F><L><E><C><G><H><V><C><S><C><T><E><C><Y><R><A><L><P><E><P><K><K><C><P><I><C><R><Q><A><I><T><R><V><I><P><L><Y><N><S> | Exhibits weak E3 ubiquitin-protein ligase activity . E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates . Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation . Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion . Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations . Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization . Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway . May also be involved in the sumoylation of the membrane fission protein DNM1L . Inhibits cell growth . When | Q969V5 |
Q9NWS8 | RMND1_HUMAN | Required for meiotic nuclear division protein 1 homolog | Homo | <M><P><A><T><L><L><R><A><V><A><R><S><H><H><I><L><S><K><A><H><Q><C><R><R><I><G><H><L><M><L><K><P><L><K><E><F><E><N><T><T><C><S><T><L><T><I><R><Q><S><L><D><L><F><L><P><D><K><T><A><S><G><L><N><K><S><Q><I><L><E><M><N><Q><K><K><S><D><T><S><M><L><S><P><L><N><A><A><R><C><Q><D><E><K><A><H><L><P><T><M><K><S><F><G><T><H><R><R><V><T><H><K><P><N><L><L><G><S><K><W><F><I><K><I><L><K><R><H><F><S><S><V><S><T><E><T><F><V><P><K><Q><D><F><P><Q><V><K><R><P><L><K><A><S><R><T><R><Q><P><S><R><T><N><L><P><V><L><S><V><N><E><D><L><M><H><C><T><A><F><A><T><A><D><E><Y><H><L><G><N><L><S><Q><D><L><A><S><H><G><Y><V><E><V><T><S><L><P><R><D><A><A><N><I><L><V><M><G><V><E><N><S><A><K><E><G><D><P><G><T><I><F><F><F><R><E><G><A><A><V><F><W><N><V><K><D><K><T><M><K><H><V><M><K><V><L><E><K><H><E><I><Q><P><Y><E><I><A><L><V><H><W><E><N><E><E><L><N><Y><I><K><I><E><G><Q><S><K><L><H><R><G><E><I><K><L><N><S><E><L><D><L><D><D><A><I><L><E><K><F><A><F><S><N><A><L><C><L><S><V><K><L><A><I><W><E><A><S><L><D><K><F><I><E><S><I><Q><S><I><P><E><A><L><K><A><G><K><K><V><K><L><S><H><E><E><V><M><Q><K><I><G><E><L><F><A><L><R><H><R><I><N><L><S><S><D><F><L><I><T><P><D><F><Y><W><D><R><E><N><L><E><G><L><Y><D><K><T><C><Q><F><L><S><I><G><R><R><V><K><V><M><N><E><K><L><Q><H><C><M><E><L><T><D><L><M><R><N><H><L><N><E><K><R><A><L><R><L><E><W><M><I><V><I><L><I><T><I><E><V><M><F><E><L><G><R><V><F><F> | Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome .<BOP> | Q9NWS8 |
O14818 | PSA7_HUMAN | Proteasome subunit XAPC7 | Homo | <M><S><Y><D><R><A><I><T><V><F><S><P><D><G><H><L><F><Q><V><E><Y><A><Q><E><A><V><K><K><G><S><T><A><V><G><V><R><G><R><D><I><V><V><L><G><V><E><K><K><S><V><A><K><L><Q><D><E><R><T><V><R><K><I><C><A><L><D><D><N><V><C><M><A><F><A><G><L><T><A><D><A><R><I><V><I><N><R><A><R><V><E><C><Q><S><H><R><L><T><V><E><D><P><V><T><V><E><Y><I><T><R><Y><I><A><S><L><K><Q><R><Y><T><Q><S><N><G><R><R><P><F><G><I><S><A><L><I><V><G><F><D><F><D><G><T><P><R><L><Y><Q><T><D><P><S><G><T><Y><H><A><W><K><A><N><A><I><G><R><G><A><K><S><V><R><E><F><L><E><K><N><Y><T><D><E><A><I><E><T><D><D><L><T><I><K><L><V><I><K><A><L><L><E><V><V><Q><S><G><G><K><N><I><E><L><A><V><M><R><R><D><Q><S><L><K><I><L><N><P><E><E><I><E><K><Y><V><A><E><I><E><K><E><K><E><E><N><E><K><K><K><Q><K><K><A><S> | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus | O14818 |
P30542 | AA1R_HUMAN | Adenosine receptor A1 | Homo | <M><P><P><S><I><S><A><F><Q><A><A><Y><I><G><I><E><V><L><I><A><L><V><S><V><P><G><N><V><L><V><I><W><A><V><K><V><N><Q><A><L><R><D><A><T><F><C><F><I><V><S><L><A><V><A><D><V><A><V><G><A><L><V><I><P><L><A><I><L><I><N><I><G><P><Q><T><Y><F><H><T><C><L><M><V><A><C><P><V><L><I><L><T><Q><S><S><I><L><A><L><L><A><I><A><V><D><R><Y><L><R><V><K><I><P><L><R><Y><K><M><V><V><T><P><R><R><A><A><V><A><I><A><G><C><W><I><L><S><F><V><V><G><L><T><P><M><F><G><W><N><N><L><S><A><V><E><R><A><W><A><A><N><G><S><M><G><E><P><V><I><K><C><E><F><E><K><V><I><S><M><E><Y><M><V><Y><F><N><F><F><V><W><V><L><P><P><L><L><L><M><V><L><I><Y><L><E><V><F><Y><L><I><R><K><Q><L><N><K><K><V><S><A><S><S><G><D><P><Q><K><Y><Y><G><K><E><L><K><I><A><K><S><L><A><L><I><L><F><L><F><A><L><S><W><L><P><L><H><I><L><N><C><I><T><L><F><C><P><S><C><H><K><P><S><I><L><T><Y><I><A><I><F><L><T><H><G><N><S><A><M><N><P><I><V><Y><A><F><R><I><Q><K><F><R><V><T><F><L><K><I><W><N><D><H><F><R><C><Q><P><A><P><P><I><D><E><D><L><P><E><E><R><P><D><D> | Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.<BOP> | P30542 |
Q8TB36 | GDAP1_HUMAN | Ganglioside-induced differentiation-associated protein 1 | Homo | <M><A><E><R><Q><E><E><Q><R><G><S><P><P><L><R><A><E><G><K><A><D><A><E><V><K><L><I><L><Y><H><W><T><H><S><F><S><S><Q><K><V><R><L><V><I><A><E><K><A><L><K><C><E><E><H><D><V><S><L><P><L><S><E><H><N><E><P><W><F><M><R><L><N><S><T><G><E><V><P><V><L><I><H><G><E><N><I><I><C><E><A><T><Q><I><I><D><Y><L><E><Q><T><F><L><D><E><R><T><P><R><L><M><P><D><K><E><S><M><Y><Y><P><R><V><Q><H><Y><R><E><L><L><D><S><L><P><M><D><A><Y><T><H><G><C><I><L><H><P><E><L><T><V><D><S><M><I><P><A><Y><A><T><T><R><I><R><S><Q><I><G><N><T><E><S><E><L><K><K><L><A><E><E><N><P><D><L><Q><E><A><Y><I><A><K><Q><K><R><L><K><S><K><L><L><D><H><D><N><V><K><Y><L><K><K><I><L><D><E><L><E><K><V><L><D><Q><V><E><T><E><L><Q><R><R><N><E><E><T><P><E><E><G><Q><Q><P><W><L><C><G><E><S><F><T><L><A><D><V><S><L><A><V><T><L><H><R><L><K><F><L><G><F><A><R><R><N><W><G><N><G><K><R><P><N><L><E><T><Y><Y><E><R><V><L><K><R><K><T><F><N><K><V><L><G><H><V><N><N><I><L><I><S><A><V><L><P><T><A><F><R><V><A><K><K><R><A><P><K><V><L><G><T><T><L><V><V><G><L><L><A><G><V><G><Y><F><A><F><M><L><F><R><K><R><L><G><S><M><I><L><A><F><R><P><R><P><N><Y><F> | Regulates the mitochondrial network by promoting mitochondrial fission.<BOP> | Q8TB36 |
Q96LT9 | RNPC3_HUMAN | U11/U12 small nuclear ribonucleoprotein 65 kDa protein | Homo | <M><A><A><P><E><Q><P><L><A><I><S><R><G><C><T><S><S><S><S><L><S><P><P><R><G><D><R><T><L><L><V><R><H><L><P><A><E><L><T><A><E><E><K><E><D><L><L><K><Y><F><G><A><Q><S><V><R><V><L><S><D><K><G><R><L><K><H><T><A><F><A><T><F><P><N><E><K><A><A><I><K><A><L><T><R><L><H><Q><L><K><L><L><G><H><T><L><V><V><E><F><A><K><E><Q><D><R><V><H><S><P><C><P><T><S><G><S><E><K><K><K><R><S><D><D><P><V><E><D><D><K><E><K><K><E><L><G><Y><L><T><V><E><N><G><I><A><P><N><H><G><L><T><F><P><L><N><S><C><L><K><Y><M><Y><P><P><P><S><S><T><I><L><A><N><I><V><N><A><L><A><S><V><P><K><F><Y><V><Q><V><L><H><L><M><N><K><M><N><L><P><T><P><F><G><P><I><T><A><R><P><P><M><Y><E><D><Y><M><P><L><H><A><P><L><P><P><T><S><P><Q><P><P><E><E><P><P><L><P><D><E><D><E><E><L><S><S><E><E><S><E><Y><E><S><T><D><D><E><D><R><Q><R><M><N><K><L><M><E><L><A><N><L><Q><P><K><R><P><K><T><I><K><Q><R><H><V><R><K><K><R><K><I><K><D><M><L><N><T><P><L><C><P><S><H><S><S><L><H><P><V><L><L><P><S><D><V><F><D><Q><P><Q><P><V><G><N><K><R><I><E><F><H><I><S><T><D><M><P><A><A><F><K><K><D><L><E><K><E><Q><N><C><E><E><K><N><H><D><L><P><A><T><E><V><D><A><S><N><I><G><F><G><K><I><F><P><K><P><N><L><D><I><T><E><E><I><K><E><D><S><D><E><M><P><S><E><C><I><S><R><R><E><L><E><K><G><R><I><S><R><E><E><M><E><T><L><S><V><F><R><S><Y><E><P><G><E><P><N><C><R><I><Y><V><K><N><L><A><K><H><V><Q><E><K><D><L><K><Y><I><F><G><R><Y><V><D><F><S><S><E><T><Q><R><I><M><F><D><I><R><L><M><K><E><G><R><M><K><G><Q><A><F><I><G><L><P><N><E><K><A><A><A><K><A><L><K><E><A><N><G><Y><V><L><F><G><K><P><M><V><V><Q><F><A><R><S><A><R><P><K><Q><D><P><K><E><G><K><R><K><C> | Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.<BOP> | Q96LT9 |
Q8NET5 | NFAM1_HUMAN | NFAT-activating protein with ITAM motif 1 | Homo | <M><E><N><Q><P><V><R><W><R><A><L><P><G><L><P><R><P><P><G><L><P><A><A><P><W><L><L><L><G><V><L><L><L><P><G><T><L><R><L><A><G><G><Q><S><V><T><H><T><G><L><P><I><M><A><S><L><A><N><T><A><I><S><F><S><C><R><I><T><Y><P><Y><T><P><Q><F><K><V><F><T><V><S><Y><F><H><E><D><L><Q><G><Q><R><S><P><K><K><P><T><N><C><H><P><G><L><G><T><E><N><Q><S><H><T><L><D><C><Q><V><T><L><V><L><P><G><A><S><A><T><G><T><Y><Y><C><S><V><H><W><P><H><S><T><V><R><G><S><G><T><F><I><L><V><R><D><A><G><Y><R><E><P><P><Q><S><P><Q><K><L><L><L><F><G><F><T><G><L><L><S><V><L><S><V><V><G><T><A><L><L><L><W><N><K><K><R><M><R><G><P><G><K><D><P><T><R><K><C><P><D><P><R><S><A><S><S><P><K><Q><H><P><S><E><S><V><Y><T><A><L><Q><R><R><E><T><E><V><Y><A><C><I><E><N><E><D><G><S><S><P><T><A><K><Q><S><P><L><S><Q><E><R><P><H><R><F><E><D><D><G><E><L><N><L><V><Y><E><N><L> | May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.<BOP> | Q8NET5 |
P07711 | CATL1_HUMAN | Cathepsin L light chain | Homo | <M><N><P><T><L><I><L><A><A><F><C><L><G><I><A><S><A><T><L><T><F><D><H><S><L><E><A><Q><W><T><K><W><K><A><M><H><N><R><L><Y><G><M><N><E><E><G><W><R><R><A><V><W><E><K><N><M><K><M><I><E><L><H><N><Q><E><Y><R><E><G><K><H><S><F><T><M><A><M><N><A><F><G><D><M><T><S><E><E><F><R><Q><V><M><N><G><F><Q><N><R><K><P><R><K><G><K><V><F><Q><E><P><L><F><Y><E><A><P><R><S><V><D><W><R><E><K><G><Y><V><T><P><V><K><N><Q><G><Q><C><G><S><C><W><A><F><S><A><T><G><A><L><E><G><Q><M><F><R><K><T><G><R><L><I><S><L><S><E><Q><N><L><V><D><C><S><G><P><Q><G><N><E><G><C><N><G><G><L><M><D><Y><A><F><Q><Y><V><Q><D><N><G><G><L><D><S><E><E><S><Y><P><Y><E><A><T><E><E><S><C><K><Y><N><P><K><Y><S><V><A><N><D><T><G><F><V><D><I><P><K><Q><E><K><A><L><M><K><A><V><A><T><V><G><P><I><S><V><A><I><D><A><G><H><E><S><F><L><F><Y><K><E><G><I><Y><F><E><P><D><C><S><S><E><D><M><D><H><G><V><L><V><V><G><Y><G><F><E><S><T><E><S><D><N><N><K><Y><W><L><V><K><N><S><W><G><E><E><W><G><M><G><G><Y><V><K><M><A><K><D><R><R><N><H><C><G><I><A><S><A><A><S><Y><P><T><V> | Functions in the regulation of cell cycle progression through proteolytic processing of the CUX1 transcription factor . Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and localize to the nucleus where they cleave the CUX1 transcription factor and modify its DNA binding properties .<BOP> | P07711 |
Q8WXH6 | RB40A_HUMAN | SOCS box-containing protein RAR2A | Homo | <M><S><A><P><G><S><P><D><Q><A><Y><D><F><L><L><K><F><L><L><V><G><D><R><D><V><G><K><S><E><I><L><E><S><L><Q><D><G><A><A><E><S><P><Y><S><H><L><G><G><I><D><Y><K><T><T><T><I><L><L><D><G><Q><R><V><K><L><K><L><W><D><T><S><G><Q><G><R><F><C><T><I><F><R><S><Y><S><R><G><A><Q><G><V><I><L><V><Y><D><I><A><N><R><W><S><F><E><G><M><D><R><W><I><K><K><I><E><E><H><A><P><G><V><P><K><I><L><V><G><N><R><L><H><L><A><F><K><R><Q><V><P><R><E><Q><A><Q><A><Y><A><E><R><L><G><V><T><F><F><E><V><S><P><L><C><N><F><N><I><I><E><S><F><T><E><L><A><R><I><V><L><L><R><H><R><M><N><W><L><G><R><P><S><K><V><L><S><L><Q><D><L><C><C><R><T><I><V><S><C><T><P><V><H><L><V><D><K><L><P><L><P><S><T><L><R><S><H><L><K><S><F><S><M><A><K><G><L><N><A><R><M><M><R><G><L><S><Y><S><L><T><T><S><S><T><H><K><S><S><L><C><K><V><E><I><V><C><P><P><Q><S><P><P><K><N><C><T><R><N><S><C><K><I><S> | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.<BOP> | Q8WXH6 |
O14562 | UBFD1_HUMAN | Ubiquitin-binding protein homolog | Homo | <M><A><A><A><G><A><P><D><G><M><E><E><P><G><M><D><T><E><A><E><T><V><A><T><E><A><P><A><R><P><V><N><C><L><E><A><E><A><A><A><G><A><A><A><E><D><S><G><A><A><R><G><S><L><Q><P><A><P><A><Q><P><P><G><D><P><A><A><Q><A><S><V><S><N><G><E><D><A><G><G><G><A><G><R><E><L><V><D><L><K><I><I><W><N><K><T><K><H><D><V><K><F><P><L><D><S><T><G><S><E><L><K><Q><K><I><H><S><I><T><G><L><P><P><A><M><Q><K><V><M><Y><K><G><L><V><P><E><D><K><T><L><R><E><I><K><V><T><S><G><A><K><I><M><V><V><G><S><T><I><N><D><V><L><A><V><N><T><P><K><D><A><A><Q><Q><D><A><K><A><E><E><N><K><K><E><P><L><C><R><Q><K><Q><H><R><K><V><L><D><K><G><K><P><E><D><V><M><P><S><V><K><G><A><Q><E><R><L><P><T><V><P><L><S><G><M><Y><N><K><S><G><G><K><V><R><L><T><F><K><L><E><Q><D><Q><L><W><I><G><T><K><E><R><T><E><K><L><P><M><G><S><I><K><N><V><V><S><E><P><I><E><G><H><E><D><Y><H><M><M><A><F><Q><L><G><P><T><E><A><S><Y><Y><W><V><Y><W><V><P><T><Q><Y><V><D><A><I><K><D><T><V><L><G><K><W><Q><Y><F> | May play a role as NF-kappa-B regulator.<BOP> | O14562 |
O76000 | OR2B3_HUMAN | Olfactory receptor OR6-14 | Homo | <M><N><W><E><N><E><S><S><P><K><E><F><I><L><L><G><F><S><D><R><A><W><L><Q><M><P><L><F><V><V><L><L><I><S><Y><T><I><T><I><F><G><N><V><S><I><M><M><V><C><I><L><D><P><K><L><H><T><P><M><Y><F><F><L><T><N><L><S><I><L><D><L><C><Y><T><T><T><T><V><P><H><M><L><V><N><I><G><C><N><K><K><T><I><S><Y><A><G><C><V><A><H><L><I><I><F><L><A><L><G><A><T><E><C><L><L><L><A><V><M><S><F><D><R><Y><V><A><V><C><R><P><L><H><Y><V><V><I><M><N><Y><W><F><C><L><R><M><A><A><F><S><W><L><I><G><F><G><N><S><V><L><Q><S><S><L><T><L><N><M><P><R><C><G><H><Q><E><V><D><H><F><F><C><E><V><P><A><L><L><K><L><S><C><A><D><T><K><P><I><E><A><E><L><F><F><F><S><V><L><I><L><L><I><P><V><T><L><I><L><I><S><Y><G><F><I><A><Q><A><V><L><K><I><R><S><A><E><G><R><Q><K><A><F><G><T><C><G><S><H><M><I><V><V><S><L><F><Y><G><T><A><I><Y><M><Y><L><Q><P><P><S><S><T><S><K><D><W><G><K><M><V><S><L><F><Y><G><I><I><T><S><M><L><N><S><L><I><Y><S><L><R><N><K><D><M><K><E><A><F><K><R><L><M><P><R><I><F><F><C><K><K> | Odorant receptor.<BOP> | O76000 |
Q9H3Q3 | G3ST2_HUMAN | Glycoprotein beta-Gal 3'-sulfotransferase 2 | Homo | <M><M><S><M><L><G><G><L><Q><R><Y><F><R><V><I><L><L><L><L><L><A><L><T><L><L><L><L><A><G><F><L><H><S><D><L><E><L><D><T><P><L><F><G><G><Q><A><E><G><P><P><V><T><N><I><M><F><L><K><T><H><K><T><A><S><S><T><V><L><N><I><L><Y><R><F><A><E><T><H><N><L><S><V><A><L><P><A><G><S><R><V><H><L><G><Y><P><W><L><F><L><A><R><Y><V><E><G><V><G><S><Q><Q><R><F><N><I><M><C><N><H><L><R><F><N><L><P><Q><V><Q><K><V><M><P><N><D><T><F><Y><F><S><I><L><R><N><P><V><F><Q><L><E><S><S><F><I><Y><Y><K><T><Y><A><P><A><F><R><G><A><P><S><L><D><A><F><L><A><S><P><R><T><F><Y><N><D><S><R><H><L><R><N><V><Y><A><K><N><N><M><W><F><D><F><G><F><D><P><N><A><Q><C><E><E><G><Y><V><R><A><R><I><A><E><V><E><R><R><F><R><L><V><L><I><A><E><H><L><D><E><S><L><V><L><L><R><R><R><L><R><W><A><L><D><D><V><V><A><F><R><L><N><S><R><S><A><R><S><V><A><R><L><S><P><E><T><R><E><R><A><R><S><W><C><A><L><D><W><R><L><Y><E><H><F><N><R><T><L><W><A><Q><L><R><A><E><L><G><P><R><R><L><R><G><E><V><E><R><L><R><A><R><R><R><E><L><A><S><L><C><L><Q><D><G><G><A><L><K><N><H><T><Q><I><R><D><P><R><L><R><P><Y><Q><S><G><K><A><D><I><L><G><Y><N><L><R><P><G><L><D><N><Q><T><L><G><V><C><Q><R><L><V><M><P><E><L><Q><Y><M><A><R><L><Y><A><L><Q><F><P><E><K><P><L><K><N><I><P><F><L><G><A> | Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency.<BOP> | Q9H3Q3 |
Q6ZP29 | LAAT1_HUMAN | Solute carrier family 66 member 1 | Homo | <M><V><W><K><K><L><G><S><R><N><F><S><S><C><P><S><G><S><I><Q><W><I><W><D><V><L><G><E><C><A><Q><D><G><W><D><E><A><S><V><G><L><G><L><I><S><I><L><C><F><A><A><S><T><F><P><Q><F><I><K><A><Y><K><T><G><N><M><D><Q><A><L><S><L><W><F><L><L><G><W><I><G><G><D><S><C><N><L><I><G><S><F><L><A><D><Q><L><P><L><Q><T><Y><T><A><V><Y><Y><V><L><A><D><L><V><M><L><T><L><Y><F><Y><Y><K><F><R><T><R><P><S><L><L><S><A><P><I><N><S><V><L><L><F><L><M><G><M><A><C><A><T><P><L><L><S><A><A><G><P><V><A><A><P><R><E><A><F><R><G><R><A><L><L><S><V><E><S><G><S><K><P><F><T><R><Q><E><V><I><G><F><V><I><G><S><I><S><S><V><L><Y><L><L><S><R><L><P><Q><I><R><T><N><F><L><R><K><S><T><Q><G><I><S><Y><S><L><F><A><L><V><M><L><G><N><T><L><Y><G><L><S><V><L><L><K><N><P><E><E><G><Q><S><E><G><S><Y><L><L><H><H><L><P><W><L><V><G><S><L><G><V><L><L><L><D><T><I><I><S><I><Q><F><L><V><Y><R><R><S><T><A><A><S><E><L><E><P><L><L><P><S> | Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes.<BOP> | Q6ZP29 |
A6NFN3 | RFOX3_HUMAN | Neuronal nuclei antigen | Homo | <M><A><Q><P><Y><P><P><A><Q><Y><P><P><P><P><Q><N><G><I><P><A><E><Y><A><P><P><P><P><H><P><T><Q><D><Y><S><G><Q><T><P><V><P><T><E><H><G><M><T><L><Y><T><P><A><Q><T><H><P><E><Q><P><G><S><E><A><S><T><Q><P><I><A><G><T><Q><T><V><P><Q><T><D><E><A><A><Q><T><D><S><Q><P><L><H><P><S><D><P><T><E><K><Q><Q><P><K><R><L><H><V><S><N><I><P><F><R><F><R><D><P><D><L><R><Q><M><F><G><Q><F><G><K><I><L><D><V><E><I><I><F><N><E><R><G><S><K><G><F><G><F><V><T><F><E><T><S><S><D><A><D><R><A><R><E><K><L><N><G><T><I><V><E><G><R><K><I><E><V><N><N><A><T><A><R><V><M><T><N><K><K><T><G><N><P><Y><T><N><G><W><K><L><N><P><V><V><G><A><V><Y><G><P><E><F><Y><A><V><T><G><F><P><Y><P><T><T><G><T><A><V><A><Y><R><G><A><H><L><R><G><R><G><R><A><V><Y><N><T><F><R><A><A><P><P><P><P><P><I><P><T><Y><G><A><V><V><Y><Q><D><G><F><Y><G><A><E><I><Y><G><G><Y><A><A><Y><R><Y><A><Q><P><A><A><A><A><A><A><Y><S><D><S><Y><G><R><V><Y><A><A><A><D><P><Y><H><H><T><I><G><P><A><A><T><Y><S><I><G><T><M> | Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).<BOP> | A6NFN3 |
Q8IZP7 | H6ST3_HUMAN | Heparan-sulfate 6-O-sulfotransferase 3 | Homo | <M><D><E><R><F><N><K><W><L><L><T><P><V><L><T><L><L><F><V><V><I><M><Y><Q><Y><V><S><P><S><C><T><S><S><C><T><N><F><G><E><Q><P><R><A><G><E><A><G><P><P><A><V><P><G><P><A><R><R><A><Q><A><P><P><E><E><W><E><R><R><P><Q><L><P><P><P><P><R><G><P><P><E><G><P><R><G><A><A><A><P><E><E><E><D><E><E><P><G><D><P><R><E><G><E><E><E><E><E><E><D><E><P><D><P><E><A><P><E><N><G><S><L><P><R><F><V><P><R><F><N><F><S><L><K><D><L><T><R><F><V><D><F><N><I><K><G><R><D><V><I><V><F><L><H><I><Q><K><T><G><G><T><T><F><G><R><H><L><V><K><N><I><R><L><E><Q><P><C><S><C><K><A><G><Q><K><K><C><T><C><H><R><P><G><K><K><E><T><W><L><F><S><R><F><S><T><G><W><S><C><G><L><H><A><D><W><T><E><L><T><N><C><V><P><A><I><M><E><K><K><D><C><P><R><N><H><S><H><T><R><N><F><Y><Y><I><T><M><L><R><D><P><V><S><R><Y><L><S><E><W><K><H><V><Q><R><G><A><T><W><K><T><S><L><H><M><C><D><G><R><S><P><T><P><D><E><L><P><T><C><Y><P><G><D><D><W><S><G><V><S><L><R><E><F><M><D><C><T><Y><N><L><A><N><N><R><Q><V><R><M><L><A><D><L><S><L><V><G><C><Y><N><L><T><F><M><N><E><S><E><R><N><T><I><L><L><Q><S><A><K><N><N><L><K><N><M><A><F><F><G><L><T><E><F><Q><R><K><T><Q><F><L><F><E><R><T><F><N><L><K><F><I><S><P><F><T><Q><F><N><I><T><R><A><S><N><V><E><I><N><E><G><A><R><Q><R><I><E><D><L><N><F><L><D><M><Q><L><Y><E><Y><A><K><D><L><F><Q><Q><R><Y><H><H><T><K><Q><L><E><H><Q><R><D><R><Q><K><R><R><E><E><R><R><L><Q><R><E><H><R><D><H><Q><W><P><K><E><D><G><A><A><E><G><T><V><T><E><D><Y><N><S><Q><V><V><R><W> | 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.<BOP> | Q8IZP7 |
P07204 | TRBM_HUMAN | Fetomodulin | Homo | <M><L><G><V><L><V><L><G><A><L><A><L><A><G><L><G><F><P><A><P><A><E><P><Q><P><G><G><S><Q><C><V><E><H><D><C><F><A><L><Y><P><G><P><A><T><F><L><N><A><S><Q><I><C><D><G><L><R><G><H><L><M><T><V><R><S><S><V><A><A><D><V><I><S><L><L><L><N><G><D><G><G><V><G><R><R><R><L><W><I><G><L><Q><L><P><P><G><C><G><D><P><K><R><L><G><P><L><R><G><F><Q><W><V><T><G><D><N><N><T><S><Y><S><R><W><A><R><L><D><L><N><G><A><P><L><C><G><P><L><C><V><A><V><S><A><A><E><A><T><V><P><S><E><P><I><W><E><E><Q><Q><C><E><V><K><A><D><G><F><L><C><E><F><H><F><P><A><T><C><R><P><L><A><V><E><P><G><A><A><A><A><A><V><S><I><T><Y><G><T><P><F><A><A><R><G><A><D><F><Q><A><L><P><V><G><S><S><A><A><V><A><P><L><G><L><Q><L><M><C><T><A><P><P><G><A><V><Q><G><H><W><A><R><E><A><P><G><A><W><D><C><S><V><E><N><G><G><C><E><H><A><C><N><A><I><P><G><A><P><R><C><Q><C><P><A><G><A><A><L><Q><A><D><G><R><S><C><T><A><S><A><T><Q><S><C><N><D><L><C><E><H><F><C><V><P><N><P><D><Q><P><G><S><Y><S><C><M><C><E><T><G><Y><R><L><A><A><D><Q><H><R><C><E><D><V><D><D><C><I><L><E><P><S><P><C><P><Q><R><C><V><N><T><Q><G><G><F><E><C><H><C><Y><P><N><Y><D><L><V><D><G><E><C><V><E><P><V><D><P><C><F><R><A><N><C><E><Y><Q><C><Q><P><L><N><Q><T><S><Y><L><C><V><C><A><E><G><F><A><P><I><P><H><E><P><H><R><C><Q><M><F><C><N><Q><T><A><C><P><A><D><C><D><P><N><T><Q><A><S><C><E><C><P><E><G><Y><I><L><D><D><G><F><I><C><T><D><I><D><E><C><E><N><G><G><F><C><S><G><V><C><H><N><L><P><G><T><F><E><C><I><C><G><P><D><S><A><L><A><R><H><I><G><T><D><C><D><S><G><K><V><D><G><G><D><S><G><S><G><E><P><P><P><S><P><T><P><G><S><T><L><T><P><P><A><V><G><L><V><H><S><G><L><L><I><G><I><S><I><A><S><L><C><L><V><V><A><L><L><A><L><L><C><H><L><R><K><K><Q><G><A><A><R><A><K><M><E><Y><K><C><A><A><P><S><K><E><V><V><L><Q><H><V><R><T><E><R><T><P><Q><R><L> | Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.<BOP> | P07204 |
P53007 | TXTP_HUMAN | Tricarboxylate carrier protein | Homo | <M><P><A><P><R><A><P><R><A><L><A><A><A><A><P><A><S><G><K><A><K><L><T><H><P><G><K><A><I><L><A><G><G><L><A><G><G><I><E><I><C><I><T><F><P><T><E><Y><V><K><T><Q><L><Q><L><D><E><R><S><H><P><P><R><Y><R><G><I><G><D><C><V><R><Q><T><V><R><S><H><G><V><L><G><L><Y><R><G><L><S><S><L><L><Y><G><S><I><P><K><A><A><V><R><F><G><M><F><E><F><L><S><N><H><M><R><D><A><Q><G><R><L><D><S><T><R><G><L><L><C><G><L><G><A><G><V><A><E><A><V><V><V><V><C><P><M><E><T><I><K><V><K><F><I><H><D><Q><T><S><P><N><P><K><Y><R><G><F><F><H><G><V><R><E><I><V><R><E><Q><G><L><K><G><T><Y><Q><G><L><T><A><T><V><L><K><Q><G><S><N><Q><A><I><R><F><F><V><M><T><S><L><R><N><W><Y><R><G><D><N><P><N><K><P><M><N><P><L><I><T><G><V><F><G><A><I><A><G><A><A><S><V><F><G><N><T><P><L><D><V><I><K><T><R><M><Q><G><L><E><A><H><K><Y><R><N><T><W><D><C><G><L><Q><I><L><K><K><E><G><L><K><A><F><Y><K><G><T><V><P><R><L><G><R><V><C><L><D><V><A><I><V><F><V><I><Y><D><E><V><V><K><L><L><N><K><V><W><K><T><D> | Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate . Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extend cis-aconitate, maleate and succinate . In the cytoplasm citrate is important in the regulation of glycolysis through a feedback mechanism and in the production of acetyl-CoA which is needed for the synthesis of fatty acids, sterols, prostaglandins, dolichol and coenzyme Q (CoQ). Required for proper neuromuscular junction formation (Probable).<BOP> | P53007 |
O75022 | LIRB3_HUMAN | Monocyte inhibitory receptor HL9 | Homo | <M><T><P><A><L><T><A><L><L><C><L><G><L><S><L><G><P><R><T><R><V><Q><A><G><P><F><P><K><P><T><L><W><A><E><P><G><S><V><I><S><W><G><S><P><V><T><I><W><C><Q><G><S><Q><E><A><Q><E><Y><R><L><H><K><E><G><S><P><E><P><L><D><R><N><N><P><L><E><P><K><N><K><A><R><F><S><I><P><S><M><T><E><H><H><A><G><R><Y><R><C><H><Y><Y><S><S><A><G><W><S><E><P><S><D><P><L><E><M><V><M><T><G><A><Y><S><K><P><T><L><S><A><L><P><S><P><V><V><A><S><G><G><N><M><T><L><R><C><G><S><Q><K><G><Y><H><H><F><V><L><M><K><E><G><E><H><Q><L><P><R><T><L><D><S><Q><Q><L><H><S><R><G><F><Q><A><L><F><P><V><G><P><V><T><P><S><H><R><W><R><F><T><C><Y><Y><Y><Y><T><N><T><P><W><V><W><S><H><P><S><D><P><L><E><I><L><P><S><G><V><S><R><K><P><S><L><L><T><L><Q><G><P><V><L><A><P><G><Q><S><L><T><L><Q><C><G><S><D><V><G><Y><N><R><F><V><L><Y><K><E><G><E><R><D><F><L><Q><R><P><G><Q><Q><P><Q><A><G><L><S><Q><A><N><F><T><L><G><P><V><S><P><S><N><G><G><Q><Y><R><C><Y><G><A><H><N><L><S><S><E><W><S><A><P><S><D><P><L><N><I><L><M><A><G><Q><I><Y><D><T><V><S><L><S><A><Q><P><G><P><T><V><A><S><G><E><N><V><T><L><L><C><Q><S><W><W><Q><F><D><T><F><L><L><T><K><E><G><A><A><H><P><P><L><R><L><R><S><M><Y><G><A><H><K><Y><Q><A><E><F><P><M><S><P><V><T><S><A><H><A><G><T><Y><R><C><Y><G><S><Y><S><S><N><P><H><L><L><S><H><P><S><E><P><L><E><L><V><V><S><G><H><S><G><G><S><S><L><P><P><T><G><P><P><S><T><P><G><L><G><R><Y><L><E><V><L><I><G><V><S><V><A><F><V><L><L><L><F><L><L><L><F><L><L><L><R><R><Q><R><H><S><K><H><R><T><S><D><Q><R><K><T><D><F><Q><R><P><A><G><A><A><E><T><E><P><K><D><R><G><L><L><R><R><S><S><P><A><A><D><V><Q><E><E><N><L><Y><A><A><V><K><D><T><Q><S><E><D><R><V><E><L><D><S><Q><S><P><H><D><E><D><P><Q><A><V><T><Y><A><P><V><K><H><S><S><P><R><R><E><M><A><S><P><P><S><S><L><S><G><E><F><L><D><T><K><D><R><Q><V><E><E><D><R><Q><M><D><T><E><A><A><A><S><E><A><S><Q><D><V><T><Y><A><Q><L><H><S><L><T><L><R><R><K><A><T><E><P><P><P><S><Q><E><G><E><P><P><A><E><P><S><I><Y><A><T><L><A><I><H> | May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).<BOP> | O75022 |
Q5T2T1 | MPP7_HUMAN | MAGUK p55 subfamily member 7 | Homo | <M><P><A><L><S><T><G><S><G><S><D><T><G><L><Y><E><L><L><A><A><L><P><A><Q><L><Q><P><H><V><D><S><Q><E><D><L><T><F><L><W><D><M><F><G><E><K><S><L><H><S><L><V><K><I><H><E><K><L><H><Y><Y><E><K><Q><S><P><V><P><I><L><H><G><A><A><A><L><A><D><D><L><A><E><E><L><Q><N><K><P><L><N><S><E><I><R><E><L><L><K><L><L><S><K><P><N><V><K><A><L><L><S><V><H><D><T><V><A><Q><K><N><Y><D><P><V><L><P><P><M><P><E><D><I><D><D><E><E><D><S><V><K><I><I><R><L><V><K><N><R><E><P><L><G><A><T><I><K><K><D><E><Q><T><G><A><I><I><V><A><R><I><M><R><G><G><A><A><D><R><S><G><L><I><H><V><G><D><E><L><R><E><V><N><G><I><P><V><E><D><K><R><P><E><E><I><I><Q><I><L><A><Q><S><Q><G><A><I><T><F><K><I><I><P><G><S><K><E><E><T><P><S><K><E><G><K><M><F><I><K><A><L><F><D><Y><N><P><N><E><D><K><A><I><P><C><K><E><A><G><L><S><F><K><K><G><D><I><L><Q><I><M><S><Q><D><D><A><T><W><W><Q><A><K><H><E><A><D><A><N><P><R><A><G><L><I><P><S><K><H><F><Q><E><R><R><L><A><L><R><R><P><E><I><L><V><Q><P><L><K><V><S><N><R><K><S><S><G><F><R><K><S><F><R><L><S><R><K><D><K><K><T><N><K><S><M><Y><E><C><K><K><S><D><Q><Y><D><T><A><D><V><P><T><Y><E><E><V><T><P><Y><R><R><Q><T><N><E><K><Y><R><L><V><V><L><V><G><P><V><G><V><G><L><N><E><L><K><R><K><L><L><I><S><D><T><Q><H><Y><G><V><T><V><P><H><T><T><R><A><R><R><S><Q><E><S><D><G><V><E><Y><I><F><I><S><K><H><L><F><E><T><D><V><Q><N><N><K><F><I><E><Y><G><E><Y><K><N><N><Y><Y><G><T><S><I><D><S><V><R><S><V><L><A><K><N><K><V><C><L><L><D><V><Q><P><H><T><V><K><H><L><R><T><L><E><F><K><P><Y><V><I><F><I><K><P><P><S><I><E><R><L><R><E><T><R><K><N><A><K><I><I><S><S><R><D><D><Q><G><A><A><K><P><F><T><E><E><D><F><Q><E><M><I><K><S><A><Q><I><M><E><S><Q><Y><G><H><L><F><D><K><I><I><I><N><D><D><L><T><V><A><F><N><E><L><K><T><T><F><D><K><L><E><T><E><T><H><W><V><P><V><S><W><L><H><S> | Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact.<BOP> | Q5T2T1 |
Q92629 | SGCD_HUMAN | 35 kDa dystrophin-associated glycoprotein | Homo | <M><P><Q><E><Q><Y><T><H><H><R><S><T><M><P><G><S><V><G><P><Q><V><Y><K><V><G><I><Y><G><W><R><K><R><C><L><Y><F><F><V><L><L><L><M><I><L><I><L><V><N><L><A><M><T><I><W><I><L><K><V><M><N><F><T><I><D><G><M><G><N><L><R><I><T><E><K><G><L><K><L><E><G><D><S><E><F><L><Q><P><L><Y><A><K><E><I><Q><S><R><P><G><N><A><L><Y><F><K><S><A><R><N><V><T><V><N><I><L><N><D><Q><T><K><V><L><T><Q><L><I><T><G><P><K><A><V><E><A><Y><G><K><K><F><E><V><K><T><V><S><G><K><L><L><F><S><A><D><N><N><E><V><V><V><G><A><E><R><L><R><V><L><G><A><E><G><T><V><F><P><K><S><I><E><T><P><N><V><R><A><D><P><F><K><E><L><R><L><E><S><P><T><R><S><L><V><M><E><A><P><K><G><V><E><I><N><A><E><A><G><N><M><E><A><T><C><R><T><E><L><R><L><E><S><K><D><G><E><I><K><L><D><A><A><K><I><R><L><P><R><L><P><H><G><S><Y><T><P><T><G><T><R><Q><K><V><F><E><I><C><V><C><A><N><G><R><L><F><L><S><Q><A><G><A><G><S><T><C><Q><I><N><T><S><V><C><L> | Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.<BOP> | Q92629 |
Q9BUJ0 | ABHEA_HUMAN | Alpha/beta hydrolase domain-containing protein 14A | Homo | <M><V><G><A><L><C><G><C><W><F><R><L><G><G><A><R><P><L><I><P><L><G><P><T><V><V><Q><T><S><M><S><R><S><Q><V><A><L><L><G><L><S><L><L><L><M><L><L><L><Y><V><G><L><P><G><P><P><E><Q><T><S><C><L><W><G><D><P><N><V><T><V><L><A><G><L><T><P><G><N><S><P><I><F><Y><R><E><V><L><P><L><N><Q><A><H><R><V><E><V><V><L><L><H><G><K><A><F><N><S><H><T><W><E><Q><L><G><T><L><Q><L><L><S><Q><R><G><Y><R><A><V><A><L><D><L><P><G><F><G><N><S><A><P><S><K><E><A><S><T><E><A><G><R><A><A><L><L><E><R><A><L><R><D><L><E><V><Q><N><A><V><L><V><S><P><S><L><S><G><H><Y><A><L><P><F><L><M><R><G><H><H><Q><L><H><G><F><V><P><I><A><P><T><S><T><Q><N><Y><T><Q><E><Q><F><W><A><V><K><T><P><T><L><I><L><Y><G><E><L><D><H><I><L><A><R><E><S><L><R><Q><L><R><H><L><P><N><H><S><V><V><K><L><R><N><A><G><H><A><C><Y><L><H><K><P><Q><D><F><H><L><V><L><L><A><F><L><D><H><L><P> | Possible role in granule neuron development.<BOP> | Q9BUJ0 |
Q9BSU1 | PHAF1_HUMAN | Phagosome assembly factor 1 | Homo | <M><L><D><L><E><V><V><P><E><R><S><L><G><N><E><Q><W><E><F><T><L><G><M><P><L><A><Q><A><V><A><I><L><Q><K><H><C><R><I><I><K><N><V><Q><V><L><Y><S><E><Q><S><P><L><S><H><D><L><I><L><N><L><T><Q><D><G><I><K><L><M><F><D><A><F><N><Q><R><L><K><V><I><E><V><C><D><L><T><K><V><K><L><K><Y><C><G><V><H><F><N><S><Q><A><I><A><P><T><I><E><Q><I><D><Q><S><F><G><A><T><H><P><G><V><Y><N><S><A><E><Q><L><F><H><L><N><F><R><G><L><S><F><S><F><Q><L><D><S><W><T><E><A><P><K><Y><E><P><N><F><A><H><G><L><A><S><L><Q><I><P><H><G><A><T><V><K><R><M><Y><I><Y><S><G><N><S><L><Q><D><T><K><A><P><M><M><P><L><S><C><F><L><G><N><V><Y><A><E><S><V><D><V><L><R><D><G><T><G><P><A><G><L><R><L><R><L><L><A><A><G><C><G><P><G><L><L><A><D><A><K><M><R><V><F><E><R><S><V><Y><F><G><D><S><C><Q><D><V><L><S><M><L><G><S><P><H><K><V><F><Y><K><S><E><D><K><M><K><I><H><S><P><S><P><H><K><Q><V><P><S><K><C><N><D><Y><F><F><N><Y><F><T><L><G><V><D><I><L><F><D><A><N><T><H><K><V><K><K><F><V><L><H><T><N><Y><P><G><H><Y><N><F><N><I><Y><H><R><C><E><F><K><I><P><L><A><I><K><K><E><N><A><D><G><Q><T><E><T><C><T><T><Y><S><K><W><D><N><I><Q><E><L><L><G><H><P><V><E><K><P><V><V><L><H><R><S><S><S><P><N><N><T><N><P><F><G><S><T><F><C><F><G><L><Q><R><M><I><F><E><V><M><Q><N><N><H><I><A><S><V><T><L><Y><G><P><P><R><P><G><S><H><L><R><T><A><E><L><P> | Plays a regulatory role in autophagic activity. In complex with BCAS3, associates with the autophagosome formation site during both non-selective and selective autophagy.<BOP> | Q9BSU1 |
P52565 | GDIR1_HUMAN | Rho-GDI alpha | Homo | <M><A><E><Q><E><P><T><A><E><Q><L><A><Q><I><A><A><E><N><E><E><D><E><H><S><V><N><Y><K><P><P><A><Q><K><S><I><Q><E><I><Q><E><L><D><K><D><D><E><S><L><R><K><Y><K><E><A><L><L><G><R><V><A><V><S><A><D><P><N><V><P><N><V><V><V><T><G><L><T><L><V><C><S><S><A><P><G><P><L><E><L><D><L><T><G><D><L><E><S><F><K><K><Q><S><F><V><L><K><E><G><V><E><Y><R><I><K><I><S><F><R><V><N><R><E><I><V><S><G><M><K><Y><I><Q><H><T><Y><R><K><G><V><K><I><D><K><T><D><Y><M><V><G><S><Y><G><P><R><A><E><E><Y><E><F><L><T><P><V><E><E><A><P><K><G><M><L><A><R><G><S><Y><S><I><K><S><R><F><T><D><D><D><K><T><D><H><L><S><W><E><W><N><L><T><I><K><K><D><W><K><D> | Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.<BOP> | P52565 |
Q9GZT9 | EGLN1_HUMAN | SM-20 | Homo | <M><A><N><D><S><G><G><P><G><G><P><S><P><S><E><R><D><R><Q><Y><C><E><L><C><G><K><M><E><N><L><L><R><C><S><R><C><R><S><S><F><Y><C><C><K><E><H><Q><R><Q><D><W><K><K><H><K><L><V><C><Q><G><S><E><G><A><L><G><H><G><V><G><P><H><Q><H><S><G><P><A><P><P><A><A><V><P><P><P><R><A><G><A><R><E><P><R><K><A><A><A><R><R><D><N><A><S><G><D><A><A><K><G><K><V><K><A><K><P><P><A><D><P><A><A><A><A><S><P><C><R><A><A><A><G><G><Q><G><S><A><V><A><A><E><A><E><P><G><K><E><E><P><P><A><R><S><S><L><F><Q><E><K><A><N><L><Y><P><P><S><N><T><P><G><D><A><L><S><P><G><G><G><L><R><P><N><G><Q><T><K><P><L><P><A><L><K><L><A><L><E><Y><I><V><P><C><M><N><K><H><G><I><C><V><V><D><D><F><L><G><K><E><T><G><Q><Q><I><G><D><E><V><R><A><L><H><D><T><G><K><F><T><D><G><Q><L><V><S><Q><K><S><D><S><S><K><D><I><R><G><D><K><I><T><W><I><E><G><K><E><P><G><C><E><T><I><G><L><L><M><S><S><M><D><D><L><I><R><H><C><N><G><K><L><G><S><Y><K><I><N><G><R><T><K><A><M><V><A><C><Y><P><G><N><G><T><G><Y><V><R><H><V><D><N><P><N><G><D><G><R><C><V><T><C><I><Y><Y><L><N><K><D><W><D><A><K><V><S><G><G><I><L><R><I><F><P><E><G><K><A><Q><F><A><D><I><E><P><K><F><D><R><L><L><F><F><W><S><D><R><R><N><P><H><E><V><Q><P><A><Y><A><T><R><Y><A><I><T><V><W><Y><F><D><A><D><E><R><A><R><A><K><V><K><Y><L><T><G><E><K><G><V><R><V><E><L><N><K><P><S><D><S><V><G><K><D><V><F> | Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.<BOP> | Q9GZT9 |
Q3LI76 | KR151_HUMAN | Keratin-associated protein 15-1 | Homo | <M><S><Y><N><C><S><S><G><N><F><S><S><C><C><F><G><S><Y><L><R><Y><P><V><S><T><Y><N><L><F><Y><P><S><N><A><I><Y><S><P><N><T><C><Q><L><G><S><S><L><Y><N><G><C><Q><E><T><Y><C><E><P><T><S><C><Q><T><S><C><T><L><A><R><S><Y><Q><T><S><C><Y><C><P><K><N><S><I><F><C><S><P><R><Q><T><N><Y><I><R><S><L><G><C><G><N><T><G><L><G><S><L><G><C><G><S><T><G><F><Q><S><L><D><C><G><S><S><F><Y><H><P><T><T><F><S><S><R><N><F><Q><A><T><C><Y> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | Q3LI76 |
Q9UKD1 | GMEB2_HUMAN | Parvovirus initiation factor p79 | Homo | <M><A><T><P><D><V><S><V><H><M><E><E><V><V><V><V><T><T><P><D><T><A><V><D><G><S><G><V><E><G><V><K><T><V><L><V><T><T><N><L><A><P><H><G><G><D><L><T><E><D><N><M><E><T><E><N><A><A><A><A><A><A><A><A><F><T><A><S><S><Q><L><K><E><A><V><L><V><K><M><A><E><E><G><E><N><L><E><A><E><I><V><Y><P><I><T><C><G><D><S><R><A><N><L><I><W><R><K><F><V><C><P><G><I><N><V><K><C><V><Q><Y><D><E><H><V><I><S><P><K><E><F><V><H><L><A><G><K><S><T><L><K><D><W><K><R><A><I><R><M><N><G><I><M><L><R><K><I><M><D><S><G><E><L><D><F><Y><Q><H><D><K><V><C><S><N><T><C><R><S><T><K><I><D><L><S><G><A><R><V><S><L><S><S><P><T><S><A><E><Y><I><P><L><T><P><A><A><A><D><V><N><G><S><P><A><T><I><T><I><E><T><C><E><D><P><G><D><W><T><A><A><I><G><D><D><T><F><T><F><W><R><G><L><K><D><A><G><L><L><D><E><V><I><Q><E><F><H><Q><E><L><V><E><T><M><R><G><L><Q><Q><R><V><Q><D><P><P><L><Q><L><R><D><A><V><L><L><N><N><I><V><Q><N><F><G><M><L><D><L><V><K><K><V><L><A><S><H><K><C><Q><M><D><R><S><R><E><Q><Y><A><R><D><L><A><A><L><E><Q><Q><C><D><E><H><R><R><R><A><K><E><L><K><H><K><S><Q><H><L><S><N><V><L><M><T><L><T><P><V><S><L><P><P><P><V><K><R><P><R><L><A><R><A><T><S><G><P><A><A><M><A><S><Q><V><L><T><Q><S><A><Q><L><A><L><G><P><G><V><P><V><P><Q><L><T><S><V><P><L><G><K><V><V><S><T><L><P><S><T><V><L><G><K><G><S><L><Q><A><P><P><A><S><S><P><A><S><P><L><L><G><G><Y><T><V><L><A><S><S><G><S><T><Y><P><S><T><V><E><I><H><P><D><A><S><S><L><T><V><L><S><T><A><A><V><Q><D><G><S><T><V><F><K><V><V><S><P><L><Q><L><L><T><L><P><G><L><G><P><T><L><Q><N><V><A><Q><A><S><P><G><S><S><T><I><V><T><V><P><A><G><A><A><P><G><P><E><E><H><T><A><T><I><E><V><A><A><M><A><E><D><H><E><R><K> | Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.<BOP> | Q9UKD1 |
P09471 | GNAO_HUMAN | Guanine nucleotide-binding protein G(o) subunit alpha | Homo | <M><G><C><T><L><S><A><E><E><R><A><A><L><E><R><S><K><A><I><E><K><N><L><K><E><D><G><I><S><A><A><K><D><V><K><L><L><L><L><G><A><G><E><S><G><K><S><T><I><V><K><Q><M><K><I><I><H><E><D><G><F><S><G><E><D><V><K><Q><Y><K><P><V><V><Y><S><N><T><I><Q><S><L><A><A><I><V><R><A><M><D><T><L><G><I><E><Y><G><D><K><E><R><K><A><D><A><K><M><V><C><D><V><V><S><R><M><E><D><T><E><P><F><S><A><E><L><L><S><A><M><M><R><L><W><G><D><S><G><I><Q><E><C><F><N><R><S><R><E><Y><Q><L><N><D><S><A><K><Y><Y><L><D><S><L><D><R><I><G><A><A><D><Y><Q><P><T><E><Q><D><I><L><R><T><R><V><K><T><T><G><I><V><E><T><H><F><T><F><K><N><L><H><F><R><L><F><D><V><G><G><Q><R><S><E><R><K><K><W><I><H><C><F><E><D><V><T><A><I><I><F><C><V><A><L><S><G><Y><D><Q><V><L><H><E><D><E><T><T><N><R><M><H><E><S><L><M><L><F><D><S><I><C><N><N><K><F><F><I><D><T><S><I><I><L><F><L><N><K><K><D><L><F><G><E><K><I><K><K><S><P><L><T><I><C><F><P><E><Y><T><G><P><N><T><Y><E><D><A><A><A><Y><I><Q><A><Q><F><E><S><K><N><R><S><P><N><K><E><I><Y><C><H><M><T><C><A><T><D><T><N><N><I><Q><V><V><F><D><A><V><T><D><I><I><I><A><N><N><L><R><G><C><G><L><Y> | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.<BOP> | P09471 |
P22680 | CP7A1_HUMAN | Cholesterol 7-alpha-monooxygenase | Homo | <M><M><T><T><S><L><I><W><G><I><A><I><A><A><C><C><C><L><W><L><I><L><G><I><R><R><R><Q><T><G><E><P><P><L><E><N><G><L><I><P><Y><L><G><C><A><L><Q><F><G><A><N><P><L><E><F><L><R><A><N><Q><R><K><H><G><H><V><F><T><C><K><L><M><G><K><Y><V><H><F><I><T><N><P><L><S><Y><H><K><V><L><C><H><G><K><Y><F><D><W><K><K><F><H><F><A><T><S><A><K><A><F><G><H><R><S><I><D><P><M><D><G><N><T><T><E><N><I><N><D><T><F><I><K><T><L><Q><G><H><A><L><N><S><L><T><E><S><M><M><E><N><L><Q><R><I><M><R><P><P><V><S><S><N><S><K><T><A><A><W><V><T><E><G><M><Y><S><F><C><Y><R><V><M><F><E><A><G><Y><L><T><I><F><G><R><D><L><T><R><R><D><T><Q><K><A><H><I><L><N><N><L><D><N><F><K><Q><F><D><K><V><F><P><A><L><V><A><G><L><P><I><H><M><F><R><T><A><H><N><A><R><E><K><L><A><E><S><L><R><H><E><N><L><Q><K><R><E><S><I><S><E><L><I><S><L><R><M><F><L><N><D><T><L><S><T><F><D><D><L><E><K><A><K><T><H><L><V><V><L><W><A><S><Q><A><N><T><I><P><A><T><F><W><S><L><F><Q><M><I><R><N><P><E><A><M><K><A><A><T><E><E><V><K><R><T><L><E><N><A><G><Q><K><V><S><L><E><G><N><P><I><C><L><S><Q><A><E><L><N><D><L><P><V><L><D><S><I><I><K><E><S><L><R><L><S><S><A><S><L><N><I><R><T><A><K><E><D><F><T><L><H><L><E><D><G><S><Y><N><I><R><K><D><D><I><I><A><L><Y><P><Q><L><M><H><L><D><P><E><I><Y><P><D><P><L><T><F><K><Y><D><R><Y><L><D><E><N><G><K><T><K><T><T><F><Y><C><N><G><L><K><L><K><Y><Y><Y><M><P><F><G><S><G><A><T><I><C><P><G><R><L><F><A><I><H><E><I><K><Q><F><L><I><L><M><L><S><Y><F><E><L><E><L><I><E><G><Q><A><K><C><P><P><L><D><Q><S><R><A><G><L><G><I><L><P><P><L><N><D><I><E><F><K><Y><K><F><K><H><L> | A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis . 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol . Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives .<BOP> | P22680 |
A1L3X4 | MT1DP_HUMAN | Putative metallothionein MT1DP | Homo | <M><D><L><S><C><S><C><A><T><G><G><S><C><T><C><A><S><S><C><K><C><K><E><Y><K><C><T><S><C><K><K><N><C><C><S><C><C><P><M><G><C><A><K><C><A><Q><G><C><T> | Metallothioneins have a high content of cysteine residues that bind various heavy metals.<BOP> | A1L3X4 |
Q7Z4G4 | TRM11_HUMAN | tRNA guanosine-2'-O-methyltransferase TRM11 homolog | Homo | <M><A><L><S><C><T><L><N><R><Y><L><L><L><M><A><Q><E><H><L><E><F><R><L><P><E><I><K><S><L><L><L><L><F><G><G><Q><F><A><S><S><Q><E><T><Y><G><K><S><P><F><W><I><L><S><I><P><S><E><D><I><A><R><N><L><M><K><R><T><V><C><A><K><S><I><F><E><L><W><G><H><G><Q><S><P><E><E><L><Y><S><S><L><K><N><Y><P><V><E><K><M><V><P><F><L><H><S><D><S><T><Y><K><I><K><I><H><T><F><N><K><T><L><T><Q><E><E><K><I><K><R><I><D><A><L><E><F><L><P><F><E><G><K><V><N><L><K><K><P><Q><H><V><F><S><V><L><E><D><Y><G><L><D><P><N><C><I><P><E><N><P><H><N><I><Y><F><G><R><W><I><A><D><G><Q><R><E><L><I><E><S><Y><S><V><K><K><R><H><F><I><G><N><T><S><M><D><A><G><L><S><F><I><M><A><N><H><G><K><V><K><E><N><D><I><V><F><D><P><F><V><G><T><G><G><L><L><I><A><C><A><H><F><G><A><Y><V><Y><G><T><D><I><D><Y><N><T><V><H><G><L><G><K><A><T><R><K><N><Q><K><W><R><G><P><D><E><N><I><R><A><N><L><R><Q><Y><G><L><E><K><Y><Y><L><D><V><L><V><S><D><A><S><K><P><S><W><R><K><G><T><Y><F><D><A><I><I><T><D><P><P><Y><G><I><R><E><S><T><R><R><T><G><S><Q><K><E><I><P><K><G><I><E><K><W><E><K><C><P><E><S><H><V><P><V><S><L><S><Y><H><L><S><D><M><F><L><D><L><L><N><F><A><A><E><T><L><V><L><G><G><R><L><V><Y><W><L><P><V><Y><T><P><E><Y><T><E><E><M><V><P><W><H><P><C><L><E><L><V><S><N><C><E><Q><K><L><S><S><H><T><S><R><R><L><I><T><M><E><K><V><K><K><F><E><N><R><D><Q><Y><S><H><L><L><S><D><H><F><L><P><Y><Q><G><H><N><S><F><R><E><K><Y><F><S><G><V><T><K><R><I><A><K><E><E><K><S><T><Q><E> | Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.<BOP> | Q7Z4G4 |
Q16656 | NRF1_HUMAN | Alpha palindromic-binding protein | Homo | <M><E><E><H><G><V><T><Q><T><E><H><M><A><T><I><E><A><H><A><V><A><Q><Q><V><Q><Q><V><H><V><A><T><Y><T><E><H><S><M><L><S><A><D><E><D><S><P><S><S><P><E><D><T><S><Y><D><D><S><D><I><L><N><S><T><A><A><D><E><V><T><A><H><L><A><A><A><G><P><V><G><M><A><A><A><A><A><V><A><T><G><K><K><R><K><R><P><H><V><F><E><S><N><P><S><I><R><K><R><Q><Q><T><R><L><L><R><K><L><R><A><T><L><D><E><Y><T><T><R><V><G><Q><Q><A><I><V><L><C><I><S><P><S><K><P><N><P><V><F><K><V><F><G><A><A><P><L><E><N><V><V><R><K><Y><K><S><M><I><L><E><D><L><E><S><A><L><A><E><H><A><P><A><P><Q><E><V><N><S><E><L><P><P><L><T><I><D><G><I><P><V><S><V><D><K><M><T><Q><A><Q><L><R><A><F><I><P><E><M><L><K><Y><S><T><G><R><G><K><P><G><W><G><K><E><S><C><K><P><I><W><W><P><E><D><I><P><W><A><N><V><R><S><D><V><R><T><E><E><Q><K><Q><R><V><S><W><T><Q><A><L><R><T><I><V><K><N><C><Y><K><Q><H><G><R><E><D><L><L><Y><A><F><E><D><Q><Q><T><Q><T><Q><A><T><A><T><H><S><I><A><H><L><V><P><S><Q><T><V><V><Q><T><F><S><N><P><D><G><T><V><S><L><I><Q><V><G><T><G><A><T><V><A><T><L><A><D><A><S><E><L><P><T><T><V><T><V><A><Q><V><N><Y><S><A><V><A><D><G><E><V><E><Q><N><W><A><T><L><Q><G><G><E><M><T><I><Q><T><T><Q><A><S><E><A><T><Q><A><V><A><S><L><A><E><A><A><V><A><A><S><Q><E><M><Q><Q><G><A><T><V><T><M><A><L><N><S><E><A><A><A><H><A><V><A><T><L><A><E><A><T><L><Q><G><G><G><Q><I><V><L><S><G><E><T><A><A><A><V><G><A><L><T><G><V><Q><D><A><N><G><L><V><Q><I><P><V><S><M><Y><Q><T><V><V><T><S><L><A><Q><G><N><G><P><V><Q><V><A><M><A><P><V><T><T><R><I><S><D><S><A><V><T><M><D><G><Q><A><V><E><V><V><T><L><E><Q> | Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.<BOP> | Q16656 |
Q9H3S4 | TPK1_HUMAN | Thiamine pyrophosphokinase 1 | Homo | <M><E><H><A><F><T><P><L><E><P><L><L><S><T><G><N><L><K><Y><C><L><V><I><L><N><Q><P><L><D><N><Y><F><R><H><L><W><N><K><A><L><L><R><A><C><A><D><G><G><A><N><R><L><Y><D><I><T><E><G><E><R><E><S><F><L><P><E><F><I><N><G><D><F><D><S><I><R><P><E><V><R><E><Y><Y><A><T><K><G><C><E><L><I><S><T><P><D><Q><D><H><T><D><F><T><K><C><L><K><M><L><Q><K><K><I><E><E><K><D><L><K><V><D><V><I><V><T><L><G><G><L><A><G><R><F><D><Q><I><M><A><S><V><N><T><L><F><Q><A><T><H><I><T><P><F><P><I><I><I><I><Q><E><E><S><L><I><Y><L><L><Q><P><G><K><H><R><L><H><V><D><T><G><M><E><G><D><W><C><G><L><I><P><V><G><Q><P><C><M><Q><V><T><T><T><G><L><K><W><N><L><T><N><D><V><L><A><F><G><T><L><V><S><T><S><N><T><Y><D><G><S><G><V><V><T><V><E><T><D><H><P><L><L><W><T><M><A><I><K><S> | Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.<BOP> | Q9H3S4 |
P43681 | ACHA4_HUMAN | Neuronal acetylcholine receptor subunit alpha-4 | Homo | <M><E><L><G><G><P><G><A><P><R><L><L><P><P><L><L><L><L><L><G><T><G><L><L><R><A><S><S><H><V><E><T><R><A><H><A><E><E><R><L><L><K><K><L><F><S><G><Y><N><K><W><S><R><P><V><A><N><I><S><D><V><V><L><V><R><F><G><L><S><I><A><Q><L><I><D><V><D><E><K><N><Q><M><M><T><T><N><V><W><V><K><Q><E><W><H><D><Y><K><L><R><W><D><P><A><D><Y><E><N><V><T><S><I><R><I><P><S><E><L><I><W><R><P><D><I><V><L><Y><N><N><A><D><G><D><F><A><V><T><H><L><T><K><A><H><L><F><H><D><G><R><V><Q><W><T><P><P><A><I><Y><K><S><S><C><S><I><D><V><T><F><F><P><F><D><Q><Q><N><C><T><M><K><F><G><S><W><T><Y><D><K><A><K><I><D><L><V><N><M><H><S><R><V><D><Q><L><D><F><W><E><S><G><E><W><V><I><V><D><A><V><G><T><Y><N><T><R><K><Y><E><C><C><A><E><I><Y><P><D><I><T><Y><A><F><V><I><R><R><L><P><L><F><Y><T><I><N><L><I><I><P><C><L><L><I><S><C><L><T><V><L><V><F><Y><L><P><S><E><C><G><E><K><I><T><L><C><I><S><V><L><L><S><L><T><V><F><L><L><L><I><T><E><I><I><P><S><T><S><L><V><I><P><L><I><G><E><Y><L><L><F><T><M><I><F><V><T><L><S><I><V><I><T><V><F><V><L><N><V><H><H><R><S><P><R><T><H><T><M><P><T><W><V><R><R><V><F><L><D><I><V><P><R><L><L><L><M><K><R><P><S><V><V><K><D><N><C><R><R><L><I><E><S><M><H><K><M><A><S><A><P><R><F><W><P><E><P><E><G><E><P><P><A><T><S><G><T><Q><S><L><H><P><P><S><P><S><F><C><V><P><L><D><V><P><A><E><P><G><P><S><C><K><S><P><S><D><Q><L><P><P><Q><Q><P><L><E><A><E><K><A><S><P><H><P><S><P><G><P><C><R><P><P><H><G><T><Q><A><P><G><L><A><K><A><R><S><L><S><V><Q><H><M><S><S><P><G><E><A><V><E><G><G><V><R><C><R><S><R><S><I><Q><Y><C><V><P><R><D><D><A><A><P><E><A><D><G><Q><A><A><G><A><L><A><S><R><N><T><H><S><A><E><L><P><P><P><D><Q><P><S><P><C><K><C><T><C><K><K><E><P><S><S><V><S><P><S><A><T><V><K><T><R><S><T><K><A><P><P><P><H><L><P><L><S><P><A><L><T><R><A><V><E><G><V><Q><Y><I><A><D><H><L><K><A><E><D><T><D><F><S><V><K><E><D><W><K><Y><V><A><M><V><I><D><R><I><F><L><W><M><F><I><I><V><C><L><L><G><T><V><G><L><F><L><P><P><W><L><A><G><M><I> | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.<BOP> | P43681 |
Q52WX2 | SBK1_HUMAN | SH3-binding kinase 1 | Homo | <M><S><V><G><C><P><E><P><E><P><P><R><S><L><T><C><C><G><P><G><T><A><P><G><P><G><A><G><V><P><L><L><T><E><D><M><Q><A><L><T><L><R><T><L><A><A><S><D><V><T><K><H><Y><E><L><V><R><E><L><G><K><G><T><Y><G><K><V><D><L><V><V><Y><K><G><T><G><T><K><M><A><L><K><F><V><N><K><S><K><T><K><L><K><N><F><L><R><E><V><S><I><T><N><S><L><S><S><S><P><F><I><I><K><V><F><D><V><V><F><E><T><E><D><C><Y><V><F><A><Q><E><Y><A><P><A><G><D><L><F><D><I><I><P><P><Q><V><G><L><P><E><D><T><V><K><R><C><V><Q><Q><L><G><L><A><L><D><F><M><H><G><R><Q><L><V><H><R><D><I><K><P><E><N><V><L><L><F><D><R><E><C><R><R><V><K><L><A><D><F><G><M><T><R><R><V><G><C><R><V><K><R><V><S><G><T><I><P><Y><T><A><P><E><V><C><Q><A><G><R><A><D><G><L><A><V><D><T><G><V><D><V><W><A><F><G><V><L><I><F><C><V><L><T><G><N><F><P><W><E><A><A><S><G><A><D><A><F><F><E><E><F><V><R><W><Q><R><G><R><L><P><G><L><P><S><Q><W><R><R><F><T><E><P><A><L><R><M><F><Q><R><L><L><A><L><E><P><E><R><R><G><P><A><K><E><V><F><R><F><L><K><H><E><L><T><S><E><L><R><R><R><P><S><H><R><A><R><K><P><P><G><D><R><P><P><A><A><G><P><L><R><L><E><A><P><G><P><L><K><R><T><V><L><T><E><S><G><S><G><S><R><P><A><P><P><A><V><G><S><V><P><L><P><V><P><V><P><V><P><V><P><V><P><V><P><V><P><E><P><G><L><A><P><Q><G><P><P><G><R><T><D><G><R><A><D><K><S><K><G><Q><V><V><L><A><T><A><I><E><I><C><V> | May be involved in signal-transduction pathways related to the control of brain development.<BOP> | Q52WX2 |
P20292 | AL5AP_HUMAN | MK-886-binding protein | Homo | <M><D><Q><E><T><V><G><N><V><V><L><L><A><I><V><T><L><I><S><V><V><Q><N><G><F><F><A><H><K><V><E><H><E><S><R><T><Q><N><G><R><S><F><Q><R><T><G><T><L><A><F><E><R><V><Y><T><A><N><Q><N><C><V><D><A><Y><P><T><F><L><A><V><L><W><S><A><G><L><L><C><S><Q><V><P><A><A><F><A><G><L><M><Y><L><F><V><R><Q><K><Y><F><V><G><Y><L><G><E><R><T><Q><S><T><P><G><Y><I><F><G><K><R><I><I><L><F><L><F><L><M><S><V><A><G><I><F><N><Y><Y><L><I><F><F><F><G><S><D><F><E><N><Y><I><K><T><I><S><T><T><I><S><P><L><L><L><I><P> | Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.<BOP> | P20292 |
Q8NFT6 | DBF4B_HUMAN | Dbf4-related factor 1 | Homo | <M><S><E><P><G><K><G><D><D><C><L><E><L><E><S><S><M><A><E><S><R><L><R><A><P><D><L><G><V><S><R><C><L><G><K><C><Q><K><N><S><P><G><A><R><K><H><P><F><S><G><K><S><F><Y><L><D><L><P><A><G><K><N><L><Q><F><L><T><G><A><I><Q><Q><L><G><G><V><I><E><G><F><L><S><K><E><V><S><Y><I><V><S><S><R><R><E><V><K><A><E><S><S><G><K><S><H><R><G><C><P><S><P><S><P><S><E><V><R><V><E><T><S><A><M><V><D><P><K><G><S><H><P><R><P><S><R><K><P><V><D><S><V><P><L><S><R><G><K><E><L><L><Q><K><A><I><R><N><Q><G><S><I><S><G><G><G><S><G><G><S><S><S><L><L><T><N><A><R><S><W><G><V><R><I><L><H><V><D><E><M><M><M><H><V><Q><Q><L><S><L><A><S><L><C><V><K><K><Q><Q><P><K><K><P><E><G><T><C><P><A><A><E><S><R><T><R><K><V><A><R><L><K><A><P><F><L><K><I><E><D><E><S><R><K><F><R><P><F><H><H><Q><F><K><S><F><P><E><I><S><F><L><G><P><K><D><A><S><P><F><E><A><P><T><T><L><G><S><M><H><H><T><R><E><S><K><D><G><E><P><S><P><R><S><A><A><H><T><M><P><R><R><K><K><G><Y><C><E><C><C><Q><E><A><F><E><E><L><H><V><H><L><Q><S><A><Q><H><R><S><F><A><L><E><A><H><L><Y><A><E><V><D><R><I><I><A><Q><L><S><H><S><F><A><D><I><P><F><Q><A><G><L><P><R><W><S><G><S><P><A><S><D><C><D><P><L><C><P><E><T><L><H><P><H><Q><P><S><H><P><R><A><A><S><P><R><I><R><K><E><D><S><C><Q><A><S><V><T><Q><G><R><A><A><G><Q><Q><R><W><T><E><S><L><D><G><V><M><G><P><P><A><S><H><T><C><V><S><A><T><T><L><L><P><A><L><P><K><G><S><R><E><Q><G><C><L><C><P><C><P><A><S><F><T><Q><S><H><L><V><T><S><L><A><L><L><P><G><E><W><S><P><A><E><D><M><P><L><H><P><S><Q><E><N><S><F><A><P><A><D><I><P><V><K><G><P><L><L><F><P><E><A><R><P><W><L><M><S><A><R><C><W><V><R><P><F><P><F><V><T><W><G><C><L><I><P><H><D><T><T><P><L><H><E><E><V><S><P><C><P><C><L><R><L><G><Y><L><Y><L><L><L><T><Q><S><L><W><C><R><V><R><V><P><S><L><S><T><A><G><P><I><P><R><T><S><H><P><C><T><L><A><F><P><S><Y><L><N><D><H><D><L><G><H><L><C><Q><A><K><P><Q><G><W><N><T><P><Q><P><F><L><H><C><G><F><L><A><V><D><S><G> | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.<BOP> | Q8NFT6 |
O00463 | TRAF5_HUMAN | RING finger protein 84 | Homo | <M><A><Y><S><E><E><H><K><G><M><P><C><G><F><I><R><Q><N><S><G><N><S><I><S><L><D><F><E><P><S><I><E><Y><Q><F><V><E><R><L><E><E><R><Y><K><C><A><F><C><H><S><V><L><H><N><P><H><Q><T><G><C><G><H><R><F><C><Q><H><C><I><L><S><L><R><E><L><N><T><V><P><I><C><P><V><D><K><E><V><I><K><S><Q><E><V><F><K><D><N><C><C><K><R><E><V><L><N><L><Y><V><Y><C><S><N><A><P><G><C><N><A><K><V><I><L><G><R><Y><Q><D><H><L><Q><Q><C><L><F><Q><P><V><Q><C><S><N><E><K><C><R><E><P><V><L><R><K><D><L><K><E><H><L><S><A><S><C><Q><F><R><K><E><K><C><L><Y><C><K><K><D><V><V><V><I><N><L><Q><N><H><E><E><N><L><C><P><E><Y><P><V><F><C><P><N><N><C><A><K><I><I><L><K><T><E><V><D><E><H><L><A><V><C><P><E><A><E><Q><D><C><P><F><K><H><Y><G><C><A><V><T><D><K><R><R><N><L><Q><Q><H><E><H><S><A><L><R><E><H><M><R><L><V><L><E><K><N><V><Q><L><E><E><Q><I><S><D><L><H><K><S><L><E><Q><K><E><S><K><I><Q><Q><L><A><E><T><I><K><K><L><E><K><E><F><K><Q><F><A><Q><L><F><G><K><N><G><S><F><L><P><N><I><Q><V><F><A><S><H><I><D><K><S><A><W><L><E><A><Q><V><H><Q><L><L><Q><M><V><N><Q><Q><Q><N><K><F><D><L><R><P><L><M><E><A><V><D><T><V><K><Q><K><I><T><L><L><E><N><N><D><Q><R><L><A><V><L><E><E><E><T><N><K><H><D><T><H><I><N><I><H><K><A><Q><L><S><K><N><E><E><R><F><K><L><L><E><G><T><C><Y><N><G><K><L><I><W><K><V><T><D><Y><K><M><K><K><R><E><A><V><D><G><H><T><V><S><I><F><S><Q><S><F><Y><T><S><R><C><G><Y><R><L><C><A><R><A><Y><L><N><G><D><G><S><G><R><G><S><H><L><S><L><Y><F><V><V><M><R><G><E><F><D><S><L><L><Q><W><P><F><R><Q><R><V><T><L><M><L><L><D><Q><S><G><K><K><N><I><M><E><T><F><K><P><D><P><N><S><S><S><F><K><R><P><D><G><E><M><N><I><A><S><G><C><P><R><F><V><A><H><S><V><L><E><N><A><K><N><A><Y><I><K><D><D><T><L><F><L><K><V><A><V><D><L><T><D><L><E><D><L> | Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.<BOP> | O00463 |
P10632 | CP2C8_HUMAN | S-mephenytoin 4-hydroxylase | Homo | <M><E><P><F><V><V><L><V><L><C><L><S><F><M><L><L><F><S><L><W><R><Q><S><C><R><R><R><K><L><P><P><G><P><T><P><L><P><I><I><G><N><M><L><Q><I><D><V><K><D><I><C><K><S><F><T><N><F><S><K><V><Y><G><P><V><F><T><V><Y><F><G><M><N><P><I><V><V><F><H><G><Y><E><A><V><K><E><A><L><I><D><N><G><E><E><F><S><G><R><G><N><S><P><I><S><Q><R><I><T><K><G><L><G><I><I><S><S><N><G><K><R><W><K><E><I><R><R><F><S><L><T><T><L><R><N><F><G><M><G><K><R><S><I><E><D><R><V><Q><E><E><A><H><C><L><V><E><E><L><R><K><T><K><A><S><P><C><D><P><T><F><I><L><G><C><A><P><C><N><V><I><C><S><V><V><F><Q><K><R><F><D><Y><K><D><Q><N><F><L><T><L><M><K><R><F><N><E><N><F><R><I><L><N><S><P><W><I><Q><V><C><N><N><F><P><L><L><I><D><C><F><P><G><T><H><N><K><V><L><K><N><V><A><L><T><R><S><Y><I><R><E><K><V><K><E><H><Q><A><S><L><D><V><N><N><P><R><D><F><I><D><C><F><L><I><K><M><E><Q><E><K><D><N><Q><K><S><E><F><N><I><E><N><L><V><G><T><V><A><D><L><F><V><A><G><T><E><T><T><S><T><T><L><R><Y><G><L><L><L><L><L><K><H><P><E><V><T><A><K><V><Q><E><E><I><D><H><V><I><G><R><H><R><S><P><C><M><Q><D><R><S><H><M><P><Y><T><D><A><V><V><H><E><I><Q><R><Y><S><D><L><V><P><T><G><V><P><H><A><V><T><T><D><T><K><F><R><N><Y><L><I><P><K><G><T><T><I><M><A><L><L><T><S><V><L><H><D><D><K><E><F><P><N><P><N><I><F><D><P><G><H><F><L><D><K><N><G><N><F><K><K><S><D><Y><F><M><P><F><S><A><G><K><R><I><C><A><G><E><G><L><A><R><M><E><L><F><L><F><L><T><T><I><L><Q><N><F><N><L><K><S><V><D><D><L><K><N><L><N><T><T><A><V><T><K><G><I><V><S><L><P><P><S><Y><Q><I><C><F><I><P><V> | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond . Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes all trans-retinoic acid toward its 4-hydroxylated form . Displays 16-alpha hydroxylase activity toward estrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1) . Plays a role in the oxidative metabolism of xenobiotics. It is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel (taxol) .<BOP> | P10632 |
Q9BSU3 | NAA11_HUMAN | NatA catalytic subunit Naa11 | Homo | <M><N><I><R><N><A><Q><P><D><D><L><M><N><M><Q><H><C><N><L><L><C><L><P><E><N><Y><Q><M><K><Y><Y><L><Y><H><G><L><S><W><P><Q><L><S><Y><I><A><E><D><E><D><G><K><I><V><G><Y><V><L><A><K><M><E><E><E><P><D><D><V><P><H><G><H><I><T><S><L><A><V><K><R><S><H><R><R><L><G><L><A><Q><K><L><M><D><Q><A><S><R><A><M><I><E><N><F><N><A><K><Y><V><S><L><H><V><R><K><S><N><R><P><A><L><H><L><Y><S><N><T><L><N><F><Q><I><S><E><V><E><P><K><Y><Y><A><D><G><E><D><A><Y><A><M><K><R><D><L><S><Q><M><A><D><E><L><R><R><Q><M><D><L><K><K><G><G><Y><V><V><L><G><S><R><E><N><Q><E><T><Q><G><S><T><L><S><D><S><E><E><A><C><Q><Q><K><N><P><A><T><E><E><S><G><S><D><S><K><E><P><K><E><S><V><E><S><T><N><V><Q><D><S><S><E><S><S><D><S><T><S> | Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.<BOP> | Q9BSU3 |
Q587I9 | SFT2C_HUMAN | SFT2 domain-containing protein 3 | Homo | <M><A><D><L><H><R><Q><L><Q><E><Y><L><A><Q><G><K><A><G><G><P><A><A><A><E><P><L><L><A><A><E><K><A><E><E><P><G><D><R><P><A><E><E><W><L><G><R><A><G><L><R><W><T><W><A><R><S><P><A><E><S><A><A><A><G><L><T><C><L><P><S><V><T><R><G><Q><R><L><A><A><G><G><G><C><L><L><L><A><A><L><C><F><G><L><A><A><L><Y><A><P><V><L><L><L><R><A><R><K><F><A><L><L><W><S><L><G><S><A><L><A><L><A><G><S><A><L><L><R><G><G><A><A><C><G><R><L><L><R><C><E><E><A><P><S><R><P><A><L><L><Y><M><A><A><L><G><A><T><L><F><A><A><L><G><L><R><S><T><L><L><T><V><L><G><A><G><A><Q><V><A><A><L><L><A><A><L><V><G><L><L><P><W><G><G><G><T><A><L><R><L><A><L><G><R><L><G><R><G><A><G><L><A><K><V><L><P><V> | May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.<BOP> | Q587I9 |
Q99592 | ZBT18_HUMAN | Zinc finger protein C2H2-171 | Homo | <M><E><F><P><D><H><S><R><H><L><L><Q><C><L><S><E><Q><R><H><Q><G><F><L><C><D><C><T><V><L><V><G><D><A><Q><F><R><A><H><R><A><V><L><A><S><C><S><M><Y><F><H><L><F><Y><K><D><Q><L><D><K><R><D><I><V><H><L><N><S><D><I><V><T><A><P><A><F><A><L><L><L><E><F><M><Y><E><G><K><L><Q><F><K><D><L><P><I><E><D><V><L><A><A><A><S><Y><L><H><M><Y><D><I><V><K><V><C><K><K><K><L><K><E><K><A><T><T><E><A><D><S><T><K><K><E><E><D><A><S><S><C><S><D><K><V><E><S><L><S><D><G><S><S><H><I><A><G><D><L><P><S><D><E><D><E><G><E><D><E><K><L><N><I><L><P><S><K><R><D><L><A><A><E><P><G><N><M><W><M><R><L><P><S><D><S><A><G><I><P><Q><A><G><G><E><A><E><P><H><A><T><A><A><G><K><T><V><A><S><P><C><S><S><T><E><S><L><S><Q><R><S><V><T><S><V><R><D><S><A><D><V><D><C><V><L><D><L><S><V><K><S><S><L><S><G><V><E><N><L><N><S><S><Y><F><S><S><Q><D><V><L><R><S><N><L><V><Q><V><K><V><E><K><E><A><S><C><D><E><S><D><V><G><T><N><D><Y><D><M><E><H><S><T><V><K><E><S><V><S><T><N><N><R><V><Q><Y><E><P><A><H><L><A><P><L><R><E><D><S><V><L><R><E><L><D><R><E><D><K><A><S><D><D><E><M><M><T><P><E><S><E><R><V><Q><V><E><G><G><M><E><S><S><L><L><P><Y><V><S><N><I><L><S><P><A><G><Q><I><F><M><C><P><L><C><N><K><V><F><P><S><P><H><I><L><Q><I><H><L><S><T><H><F><R><E><Q><D><G><I><R><S><K><P><A><A><D><V><N><V><P><T><C><S><L><C><G><K><T><F><S><C><M><Y><T><L><K><R><H><E><R><T><H><S><G><E><K><P><Y><T><C><T><Q><C><G><K><S><F><Q><Y><S><H><N><L><S><R><H><A><V><V><H><T><R><E><K><P><H><A><C><K><W><C><E><R><R><F><T><Q><S><G><D><L><Y><R><H><I><R><K><F><H><C><E><L><V><N><S><L><S><V><K><S><E><A><L><S><L><P><T><V><R><D><W><T><L><E><D><S><S><Q><E><L><W><K> | Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.<BOP> | Q99592 |
Q9Y2G7 | ZFP30_HUMAN | Zinc finger protein 745 | Homo | <M><A><R><D><L><V><M><F><R><D><V><A><V><D><F><S><Q><E><E><W><E><C><L><N><S><Y><Q><R><N><L><Y><R><D><V><I><L><E><N><Y><S><N><L><V><S><L><A><G><C><S><I><S><K><P><D><V><I><T><L><L><E><Q><G><K><E><P><W><M><V><V><R><D><E><K><R><R><W><T><L><D><L><E><S><R><Y><D><T><K><K><L><F><Q><G><K><D><I><Y><E><M><N><L><S><Q><W><K><V><M><E><R><I><K><S><C><G><L><E><E><Q><E><S><P><H><E><V><C><F><R><Q><V><T><K><T><T><S><E><K><M><P><T><Y><R><K><L><T><S><L><P><L><Y><Q><K><S><H><N><R><E><K><P><Y><E><C><G><E><C><G><K><A><F><R><V><R><Q><Q><L><T><F><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><Q><C><A><H><L><S><R><H><Q><R><I><H><T><S><D><K><L><Y><E><C><K><K><C><G><K><I><F><T><C><G><S><D><L><R><V><H><Q><R><I><H><I><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><V><R><G><Q><L><N><L><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><Q><Y><A><H><L><T><R><H><Q><R><L><N><I><A><E><K><C><Y><E><C><K><E><C><G><Q><A><F><L><C><S><T><G><L><R><L><H><H><K><L><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><V><R><Q><Q><L><T><L><H><Q><R><I><H><T><G><E><K><P><Y><D><C><K><E><C><G><K><T><F><S><R><G><Y><H><L><T><L><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><Q><K><F><F><R><R><Y><S><E><L><I><S><H><Q><G><I><H><I><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><L><F><S><Q><L><T><Q><H><Q><S><I><H><F><G><E><K><P><F><K><C><K><E><C><E><K><T><F><R><L><L><S><Q><L><T><Q><H><Q><S><I><H><T><G><E><K><P><Y><D><C><K><E><C><G><K><A><F><R><L><H><S><S><L><I><Q><H><Q><R><I><H><S><G><E><K><P><Y><K><C><K><E><C><K><K><A><F><R><Q><H><S><H><L><T><Y><H><Q><R><I><H><N><V><T> | May be involved in transcriptional regulation.<BOP> | Q9Y2G7 |
Q07837 | SLC31_HUMAN | b(0,+)-type amino acid transport protein | Homo | <M><A><E><D><K><S><K><R><D><S><I><E><M><S><M><K><G><C><Q><T><N><N><G><F><V><H><N><E><D><I><L><E><Q><T><P><D><P><G><S><S><T><D><N><L><K><H><S><T><R><G><I><L><G><S><Q><E><P><D><F><K><G><V><Q><P><Y><A><G><M><P><K><E><V><L><F><Q><F><S><G><Q><A><R><Y><R><I><P><R><E><I><L><F><W><L><T><V><A><S><V><L><V><L><I><A><A><T><I><A><I><I><A><L><S><P><K><C><L><D><W><W><Q><E><G><P><M><Y><Q><I><Y><P><R><S><F><K><D><S><N><K><D><G><N><G><D><L><K><G><I><Q><D><K><L><D><Y><I><T><A><L><N><I><K><T><V><W><I><T><S><F><Y><K><S><S><L><K><D><F><R><Y><G><V><E><D><F><R><E><V><D><P><I><F><G><T><M><E><D><F><E><N><L><V><A><A><I><H><D><K><G><L><K><L><I><I><D><F><I><P><N><H><T><S><D><K><H><I><W><F><Q><L><S><R><T><R><T><G><K><Y><T><D><Y><Y><I><W><H><D><C><T><H><E><N><G><K><T><I><P><P><N><N><W><L><S><V><Y><G><N><S><S><W><H><F><D><E><V><R><N><Q><C><Y><F><H><Q><F><M><K><E><Q><P><D><L><N><F><R><N><P><D><V><Q><E><E><I><K><E><I><L><R><F><W><L><T><K><G><V><D><G><F><S><L><D><A><V><K><F><L><L><E><A><K><H><L><R><D><E><I><Q><V><N><K><T><Q><I><P><D><T><V><T><Q><Y><S><E><L><Y><H><D><F><T><T><T><Q><V><G><M><H><D><I><V><R><S><F><R><Q><T><M><D><Q><Y><S><T><E><P><G><R><Y><R><F><M><G><T><E><A><Y><A><E><S><I><D><R><T><V><M><Y><Y><G><L><P><F><I><Q><E><A><D><F><P><F><N><N><Y><L><S><M><L><D><T><V><S><G><N><S><V><Y><E><V><I><T><S><W><M><E><N><M><P><E><G><K><W><P><N><W><M><I><G><G><P><D><S><S><R><L><T><S><R><L><G><N><Q><Y><V><N><V><M><N><M><L><L><F><T><L><P><G><T><P><I><T><Y><Y><G><E><E><I><G><M><G><N><I><V><A><A><N><L><N><E><S><Y><D><I><N><T><L><R><S><K><S><P><M><Q><W><D><N><S><S><N><A><G><F><S><E><A><S><N><T><W><L><P><T><N><S><D><Y><H><T><V><N><V><D><V><Q><K><T><Q><P><R><S><A><L><K><L><Y><Q><D><L><S><L><L><H><A><N><E><L><L><L><N><R><G><W><F><C><H><L><R><N><D><S><H><Y><V><V><Y><T><R><E><L><D><G><I><D><R><I><F><I><V><V><L><N><F><G><E><S><T><L><L><N><L><H><N><M><I><S><G><L><P><A><K><M><R><I><R><L><S><T><N><S><A><D><K><G><S><K><V><D><T><S><G><I><F><L><D><K><G><E><G><L><I><F><E><H><N><T><K><N><L><L><H><R><Q><T><A><F><R><D><R><C><F><V><S><N><R><A><C><Y><S><S><V><L><N><I><L><Y><T><S><C> | Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule.<BOP> | Q07837 |
P39900 | MMP12_HUMAN | Matrix metalloproteinase-12 | Homo | <M><K><F><L><L><I><L><L><L><Q><A><T><A><S><G><A><L><P><L><N><S><S><T><S><L><E><K><N><N><V><L><F><G><E><R><Y><L><E><K><F><Y><G><L><E><I><N><K><L><P><V><T><K><M><K><Y><S><G><N><L><M><K><E><K><I><Q><E><M><Q><H><F><L><G><L><K><V><T><G><Q><L><D><T><S><T><L><E><M><M><H><A><P><R><C><G><V><P><D><V><H><H><F><R><E><M><P><G><G><P><V><W><R><K><H><Y><I><T><Y><R><I><N><N><Y><T><P><D><M><N><R><E><D><V><D><Y><A><I><R><K><A><F><Q><V><W><S><N><V><T><P><L><K><F><S><K><I><N><T><G><M><A><D><I><L><V><V><F><A><R><G><A><H><G><D><F><H><A><F><D><G><K><G><G><I><L><A><H><A><F><G><P><G><S><G><I><G><G><D><A><H><F><D><E><D><E><F><W><T><T><H><S><G><G><T><N><L><F><L><T><A><V><H><E><I><G><H><S><L><G><L><G><H><S><S><D><P><K><A><V><M><F><P><T><Y><K><Y><V><D><I><N><T><F><R><L><S><A><D><D><I><R><G><I><Q><S><L><Y><G><D><P><K><E><N><Q><R><L><P><N><P><D><N><S><E><P><A><L><C><D><P><N><L><S><F><D><A><V><T><T><V><G><N><K><I><F><F><F><K><D><R><F><F><W><L><K><V><S><E><R><P><K><T><S><V><N><L><I><S><S><L><W><P><T><L><P><S><G><I><E><A><A><Y><E><I><E><A><R><N><Q><V><F><L><F><K><D><D><K><Y><W><L><I><S><N><L><R><P><E><P><N><Y><P><K><S><I><H><S><F><G><F><P><N><F><V><K><K><I><D><A><A><V><F><N><P><R><F><Y><R><T><Y><F><F><V><D><N><Q><Y><W><R><Y><D><E><R><R><Q><M><M><D><P><G><Y><P><K><L><I><T><K><N><F><Q><G><I><G><P><K><I><D><A><V><F><Y><S><K><N><K><Y><Y><Y><F><F><Q><G><S><N><Q><F><E><Y><D><F><L><L><Q><R><I><T><K><T><L><K><S><N><S><W><F><G><C> | May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.<BOP> | P39900 |
Q8NGY9 | OR2L8_HUMAN | Olfactory receptor OR1-46 | Homo | <M><E><N><Y><N><Q><T><S><T><D><F><I><L><L><G><L><F><P><P><S><R><I><D><L><F><F><F><I><L><I><V><F><I><F><L><M><A><L><I><G><N><L><S><M><I><L><L><I><F><L><D><T><H><L><H><T><P><M><Y><F><L><L><S><Q><L><S><L><I><D><L><N><Y><I><S><T><I><V><P><K><M><A><S><D><F><L><H><G><N><K><S><I><S><F><T><G><C><G><I><Q><S><F><F><F><L><A><L><G><G><A><E><A><L><L><L><A><S><M><A><Y><D><R><Y><I><A><I><C><F><P><L><H><Y><L><I><R><M><S><K><R><V><C><V><L><M><I><T><G><S><W><I><I><G><S><I><N><A><C><A><H><T><V><Y><V><L><H><I><P><Y><C><R><S><R><A><I><N><H><F><F><C><D><V><P><A><M><V><T><L><A><C><M><D><T><W><V><Y><E><G><T><V><F><L><S><A><T><I><F><L><V><F><P><F><I><G><I><S><C><S><Y><G><Q><V><L><F><A><V><Y><H><M><K><S><A><E><G><R><K><K><A><Y><L><T><C><S><T><H><L><T><V><V><T><F><Y><Y><A><P><F><V><Y><T><Y><L><R><P><R><S><L><R><S><P><T><E><D><K><V><L><A><V><F><Y><T><I><L><T><P><M><L><N><P><I><I><Y><S><L><R><N><K><E><V><M><G><A><L><T><R><V><S><Q><R><I><C><S><V><K><M> | Odorant receptor.<BOP> | Q8NGY9 |
Q8NGR3 | OR1K1_HUMAN | Olfactory receptor 1K1 | Homo | <M><E><A><A><N><E><S><S><E><G><I><S><F><V><L><L><G><L><T><T><S><P><G><Q><Q><R><P><L><F><V><L><F><L><L><L><Y><V><A><S><L><L><G><N><G><L><I><V><A><A><I><Q><A><S><P><A><L><H><A><P><M><Y><F><L><L><A><H><L><S><F><A><D><L><C><F><A><S><V><T><V><P><K><M><L><A><N><L><L><A><H><D><H><S><I><S><L><A><G><C><L><T><Q><M><Y><F><F><F><A><L><G><V><T><D><S><C><L><L><A><A><M><A><Y><D><C><Y><V><A><I><R><H><P><L><P><Y><A><T><R><M><S><R><A><M><C><A><A><L><V><G><M><A><W><L><V><S><H><V><H><S><L><L><Y><I><L><L><M><A><R><L><S><F><C><A><S><H><Q><V><P><H><F><F><C><D><H><Q><P><L><L><R><L><S><C><S><D><T><H><H><I><Q><L><L><I><F><T><E><G><A><A><V><V><V><T><P><F><L><L><I><L><A><S><Y><G><A><I><A><A><A><V><L><Q><L><P><S><A><S><G><R><L><R><A><V><S><T><C><G><S><H><L><A><V><V><S><L><F><Y><G><T><V><I><A><V><Y><F><Q><A><T><S><R><R><E><A><E><W><G><R><V><A><T><V><M><Y><T><V><V><T><P><M><L><N><P><I><I><Y><S><L><W><N><R><D><V><Q><G><A><L><R><A><L><L><I><G><R><R><I><S><A><S><D><S> | Odorant receptor.<BOP> | Q8NGR3 |
P02746 | C1QB_HUMAN | Complement C1q subcomponent subunit B | Homo | <M><M><M><K><I><P><W><G><S><I><P><V><L><M><L><L><L><L><L><G><L><I><D><I><S><Q><A><Q><L><S><C><T><G><P><P><A><I><P><G><I><P><G><I><P><G><T><P><G><P><D><G><Q><P><G><T><P><G><I><K><G><E><K><G><L><P><G><L><A><G><D><H><G><E><F><G><E><K><G><D><P><G><I><P><G><N><P><G><K><V><G><P><K><G><P><M><G><P><K><G><G><P><G><A><P><G><A><P><G><P><K><G><E><S><G><D><Y><K><A><T><Q><K><I><A><F><S><A><T><R><T><I><N><V><P><L><R><R><D><Q><T><I><R><F><D><H><V><I><T><N><M><N><N><N><Y><E><P><R><S><G><K><F><T><C><K><V><P><G><L><Y><Y><F><T><Y><H><A><S><S><R><G><N><L><C><V><N><L><M><R><G><R><E><R><A><Q><K><V><V><T><F><C><D><Y><A><Y><N><T><F><Q><V><T><T><G><G><M><V><L><K><L><E><Q><G><E><N><V><F><L><Q><A><T><D><K><N><S><L><L><G><M><E><G><A><N><S><I><F><S><G><F><L><L><F><P><D><M><E><A> | C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.<BOP> | P02746 |
O75594 | PGRP1_HUMAN | Peptidoglycan recognition protein short | Homo | <M><S><R><R><S><M><L><L><A><W><A><L><P><S><L><L><R><L><G><A><A><Q><E><T><E><D><P><A><C><C><S><P><I><V><P><R><N><E><W><K><A><L><A><S><E><C><A><Q><H><L><S><L><P><L><R><Y><V><V><V><S><H><T><A><G><S><S><C><N><T><P><A><S><C><Q><Q><Q><A><R><N><V><Q><H><Y><H><M><K><T><L><G><W><C><D><V><G><Y><N><F><L><I><G><E><D><G><L><V><Y><E><G><R><G><W><N><F><T><G><A><H><S><G><H><L><W><N><P><M><S><I><G><I><S><F><M><G><N><Y><M><D><R><V><P><T><P><Q><A><I><R><A><A><Q><G><L><L><A><C><G><V><A><Q><G><A><L><R><S><N><Y><V><L><K><G><H><R><D><V><Q><R><T><L><S><P><G><N><Q><L><Y><H><L><I><Q><N><W><P><H><Y><R><S><P> | Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity . Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane . In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement . Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system . Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity . Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor .<BOP> | O75594 |
P38432 | COIL_HUMAN | p80-coilin | Homo | <M><A><A><S><E><T><V><R><L><R><L><Q><F><D><Y><P><P><P><A><T><P><H><C><T><A><F><W><L><L><V><D><L><N><R><C><R><V><V><T><D><L><I><S><L><I><R><Q><R><F><G><F><S><S><G><A><F><L><G><L><Y><L><E><G><G><L><L><P><P><A><E><S><A><R><L><V><R><D><N><D><C><L><R><V><K><L><E><E><R><G><V><A><E><N><S><V><V><I><S><N><G><D><I><N><L><S><L><R><K><A><K><K><R><A><F><Q><L><E><E><G><E><E><T><E><P><D><C><K><Y><S><K><K><H><W><K><S><R><E><N><N><N><N><N><E><K><V><L><D><L><E><P><K><A><V><T><D><Q><T><V><S><K><K><N><K><R><K><N><K><A><T><C><G><T><V><G><D><D><N><E><E><A><K><R><K><S><P><K><K><K><E><K><C><E><Y><K><K><K><A><K><N><P><K><S><P><K><V><Q><A><V><K><D><W><A><N><Q><R><C><S><S><P><K><G><S><A><R><N><S><L><V><K><A><K><R><K><G><S><V><S><V><C><S><K><E><S><P><S><S><S><S><E><S><E><S><C><D><E><S><I><S><D><G><P><S><K><V><T><L><E><A><R><N><S><S><E><K><L><P><T><E><L><S><K><E><E><P><S><T><K><N><T><T><A><D><K><L><A><I><K><L><G><F><S><L><T><P><S><K><G><K><T><S><G><T><T><S><S><S><S><D><S><S><A><E><S><D><D><Q><C><L><M><S><S><S><T><P><E><C><A><A><G><F><L><K><T><V><G><L><F><A><G><R><G><R><P><G><P><G><L><S><S><Q><T><A><G><A><A><G><W><R><R><S><G><S><N><G><G><G><Q><A><P><G><A><S><P><S><V><S><L><P><A><S><L><G><R><G><W><G><R><E><E><N><L><F><S><W><K><G><A><K><G><R><G><M><R><G><R><G><R><G><R><G><H><P><V><S><C><V><V><N><R><S><T><D><N><Q><R><Q><Q><Q><L><N><D><V><V><K><N><S><S><T><I><I><Q><N><P><V><E><T><P><K><K><D><Y><S><L><L><P><L><L><A><A><A><P><Q><V><G><E><K><I><A><F><K><L><L><E><L><T><S><S><Y><S><P><D><V><S><D><Y><K><E><G><R><I><L><S><H><N><P><E><T><Q><Q><V><D><I><E><I><L><S><S><L><P><A><L><R><E><P><G><K><F><D><L><V><Y><H><N><E><N><G><A><E><V><V><E><Y><A><V><T><Q><E><S><K><I><T><V><F><W><K><E><L><I><D><P><R><L><I><I><E><S><P><S><N><T><S><S><T><E><P><A> | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.<BOP> | P38432 |
P24588 | AKAP5_HUMAN | cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein | Homo | <M><E><T><T><I><S><E><I><H><V><E><N><K><D><E><K><R><S><A><E><G><S><P><G><A><E><R><Q><K><E><K><A><S><M><L><C><F><K><R><R><K><K><A><A><K><A><L><K><P><K><A><G><S><E><A><A><D><V><A><R><K><C><P><Q><E><A><G><A><S><D><Q><P><E><P><T><R><G><A><W><A><S><L><K><R><L><V><T><R><R><K><R><S><E><S><S><K><Q><Q><K><P><L><E><G><E><M><Q><P><A><I><N><A><E><D><A><D><L><S><K><K><K><A><K><S><R><L><K><I><P><C><I><K><F><P><R><G><P><K><R><S><N><H><S><K><I><I><E><D><S><D><C><S><I><K><V><Q><E><E><A><E><I><L><D><I><Q><T><Q><T><P><L><N><D><Q><A><T><K><A><K><S><T><Q><D><L><S><E><G><I><S><R><K><D><G><D><E><V><C><E><S><N><V><S><N><S><T><T><S><G><E><K><V><I><S><V><E><L><G><L><D><N><G><H><S><A><I><Q><T><G><T><L><I><L><E><E><I><E><T><I><K><E><K><Q><D><V><Q><P><Q><Q><A><S><P><L><E><T><S><E><T><D><H><Q><Q><P><V><L><S><D><V><P><P><L><P><A><I><P><D><Q><Q><I><V><E><E><A><S><N><S><T><L><E><S><A><P><N><G><K><D><Y><E><S><T><E><I><V><A><E><E><T><K><P><K><D><T><E><L><S><Q><E><S><D><F><K><E><N><G><I><T><E><E><K><S><K><S><E><E><S><K><R><M><E><P><I><A><I><I><I><T><D><T><E><I><S><E><F><D><V><T><K><S><K><N><V><P><K><Q><F><L><I><S><A><E><N><E><Q><V><G><V><F><A><N><D><N><G><F><E><D><R><T><S><E><Q><Y><E><T><L><L><I><E><T><A><S><S><L><V><K><N><A><I><Q><L><S><I><E><Q><L><V><N><E><M><A><S><D><D><N><K><I><N><N><L><L><Q> | Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors . Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses .<BOP> | P24588 |
Q96A57 | TM230_HUMAN | Transmembrane protein 230 | Homo | <M><M><P><S><R><T><N><L><A><T><G><I><P><S><S><K><V><K><Y><S><R><L><S><S><T><D><D><G><Y><I><D><L><Q><F><K><K><T><P><P><K><I><P><Y><K><A><I><A><L><A><T><V><L><F><L><I><G><A><F><L><I><I><I><G><S><L><L><L><S><G><Y><I><S><K><G><G><A><D><R><A><V><P><V><L><I><I><G><I><L><V><F><L><P><G><F><Y><H><L><R><I><A><Y><Y><A><S><K><G><Y><R><G><Y><S><Y><D><D><I><P><D><F><D><D> | Involved in trafficking and recycling of synaptic vesicles.<BOP> | Q96A57 |
O95948 | ONEC2_HUMAN | Transcription factor ONECUT-2 | Homo | <M><K><A><A><Y><T><A><Y><R><C><L><T><K><D><L><E><G><C><A><M><N><P><E><L><T><M><E><S><L><G><T><L><H><G><P><A><G><G><G><S><G><G><G><G><G><G><G><G><G><G><G><G><G><G><P><G><H><E><Q><E><L><L><A><S><P><S><P><H><H><A><G><R><G><A><A><G><S><L><R><G><P><P><P><P><P><T><A><H><Q><E><L><G><T><A><A><A><A><A><A><A><A><S><R><S><A><M><V><T><S><M><A><S><I><L><D><G><G><D><Y><R><P><E><L><S><I><P><L><H><H><A><M><S><M><S><C><D><S><S><P><P><G><M><G><M><S><N><T><Y><T><T><L><T><P><L><Q><P><L><P><P><I><S><T><V><S><D><K><F><H><H><P><H><P><H><H><H><P><H><H><H><H><H><H><H><H><Q><R><L><S><G><N><V><S><G><S><F><T><L><M><R><D><E><R><G><L><P><A><M><N><N><L><Y><S><P><Y><K><E><M><P><G><M><S><Q><S><L><S><P><L><A><A><T><P><L><G><N><G><L><G><G><L><H><N><A><Q><Q><S><L><P><N><Y><G><P><P><G><H><D><K><M><L><S><P><N><F><D><A><H><H><T><A><M><L><T><R><G><E><Q><H><L><S><R><G><L><G><T><P><P><A><A><M><M><S><H><L><N><G><L><H><H><P><G><H><T><Q><S><H><G><P><V><L><A><P><S><R><E><R><P><P><S><S><S><S><G><S><Q><V><A><T><S><G><Q><L><E><E><I><N><T><K><E><V><A><Q><R><I><T><A><E><L><K><R><Y><S><I><P><Q><A><I><F><A><Q><R><V><L><C><R><S><Q><G><T><L><S><D><L><L><R><N><P><K><P><W><S><K><L><K><S><G><R><E><T><F><R><R><M><W><K><W><L><Q><E><P><E><F><Q><R><M><S><A><L><R><L><A><A><C><K><R><K><E><Q><E><P><N><K><D><R><N><N><S><Q><K><K><S><R><L><V><F><T><D><L><Q><R><R><T><L><F><A><I><F><K><E><N><K><R><P><S><K><E><M><Q><I><T><I><S><Q><Q><L><G><L><E><L><T><T><V><S><N><F><F><M><N><A><R><R><R><S><L><E><K><W><Q><D><D><L><S><T><G><G><S><S><S><T><S><S><T><C><T><K><A> | Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.<BOP> | O95948 |
O94919 | ENDD1_HUMAN | Endonuclease domain-containing 1 protein | Homo | <M><G><T><A><R><W><L><A><L><G><S><L><F><A><L><A><G><L><L><E><G><R><L><V><G><E><E><E><A><G><F><G><E><C><D><K><F><F><Y><A><G><T><P><P><A><G><L><A><A><D><S><H><V><K><I><C><Q><R><A><E><G><A><E><R><F><A><T><L><Y><S><T><R><D><R><I><P><V><Y><S><A><F><R><A><P><R><P><A><P><G><G><A><E><Q><R><W><L><V><E><P><Q><I><D><D><P><N><S><N><L><E><E><A><I><N><E><A><E><A><I><T><S><V><N><S><L><G><S><K><Q><A><L><N><T><D><Y><L><D><S><D><Y><Q><R><G><Q><L><Y><P><F><S><L><S><S><D><V><Q><V><A><T><F><T><L><T><N><S><A><P><M><T><Q><S><F><Q><E><R><W><Y><V><N><L><H><S><L><M><D><R><A><L><T><P><Q><C><G><S><G><E><D><L><Y><I><L><T><G><T><V><P><S><D><Y><R><V><K><D><K><V><A><V><P><E><F><V><W><L><A><A><C><C><A><V><P><G><G><G><W><A><M><G><F><V><K><H><T><R><D><S><D><I><I><E><D><V><M><V><K><D><L><Q><K><L><L><P><F><N><P><Q><L><F><Q><N><N><C><G><E><T><E><Q><D><T><E><K><M><K><K><I><L><E><V><V><N><Q><I><Q><D><E><E><R><M><V><Q><S><Q><K><S><S><S><P><L><S><S><T><R><S><K><R><S><T><L><L><P><P><E><A><S><E><G><S><S><S><F><L><G><K><L><M><G><F><I><A><T><P><F><I><K><L><F><Q><L><I><Y><Y><L><V><V><A><I><L><K><N><I><V><Y><F><L><W><C><V><T><K><Q><V><I><N><G><I><E><S><C><L><Y><R><L><G><S><A><T><I><S><Y><F><M><A><I><G><E><E><L><V><S><I><P><W><K><V><L><K><V><V><A><K><V><I><R><A><L><L><R><I><L><C><C><L><L><K><A><I><C><R><V><L><S><I><P><V><R><V><L><V><D><V><A><T><F><P><V><Y><T><M><G><A><I><P><I><V><C><K><D><I><A><L><G><L><G><G><T><V><S><L><L><F><D><T><A><F><G><T><L><G><G><L><F><Q><V><V><F><S><V><C><K><R><I><G><Y><K><V><T><F><D><N><S><G><E><L> | May act as a DNase and a RNase. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26.<BOP> | O94919 |
Q01081 | U2AF1_HUMAN | U2 snRNP auxiliary factor small subunit | Homo | <M><A><E><Y><L><A><S><I><F><G><T><E><K><D><K><V><N><C><S><F><Y><F><K><I><G><A><C><R><H><G><D><R><C><S><R><L><H><N><K><P><T><F><S><Q><T><I><A><L><L><N><I><Y><R><N><P><Q><N><S><S><Q><S><A><D><G><L><R><C><A><V><S><D><V><E><M><Q><E><H><Y><D><E><F><F><E><E><V><F><T><E><M><E><E><K><Y><G><E><V><E><E><M><N><V><C><D><N><L><G><D><H><L><V><G><N><V><Y><V><K><F><R><R><E><E><D><A><E><K><A><V><I><D><L><N><N><R><W><F><N><G><Q><P><I><H><A><E><L><S><P><V><T><D><F><R><E><A><C><C><R><Q><Y><E><M><G><E><C><T><R><G><G><F><C><N><F><M><H><L><K><P><I><S><R><E><L><R><R><E><L><Y><G><R><R><R><K><K><H><R><S><R><S><R><S><R><E><R><R><S><R><S><R><D><R><G><R><G><G><G><G><G><G><G><G><G><G><G><G><R><E><R><D><R><R><R><S><R><D><R><E><R><S><G><R><F> | Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.<BOP> | Q01081 |
P19544 | WT1_HUMAN | WT33 | Homo | <M><G><S><D><V><R><D><L><N><A><L><L><P><A><V><P><S><L><G><G><G><G><G><C><A><L><P><V><S><G><A><A><Q><W><A><P><V><L><D><F><A><P><P><G><A><S><A><Y><G><S><L><G><G><P><A><P><P><P><A><P><P><P><P><P><P><P><P><P><H><S><F><I><K><Q><E><P><S><W><G><G><A><E><P><H><E><E><Q><C><L><S><A><F><T><V><H><F><S><G><Q><F><T><G><T><A><G><A><C><R><Y><G><P><F><G><P><P><P><P><S><Q><A><S><S><G><Q><A><R><M><F><P><N><A><P><Y><L><P><S><C><L><E><S><Q><P><A><I><R><N><Q><G><Y><S><T><V><T><F><D><G><T><P><S><Y><G><H><T><P><S><H><H><A><A><Q><F><P><N><H><S><F><K><H><E><D><P><M><G><Q><Q><G><S><L><G><E><Q><Q><Y><S><V><P><P><P><V><Y><G><C><H><T><P><T><D><S><C><T><G><S><Q><A><L><L><L><R><T><P><Y><S><S><D><N><L><Y><Q><M><T><S><Q><L><E><C><M><T><W><N><Q><M><N><L><G><A><T><L><K><G><V><A><A><G><S><S><S><S><V><K><W><T><E><G><Q><S><N><H><S><T><G><Y><E><S><D><N><H><T><T><P><I><L><C><G><A><Q><Y><R><I><H><T><H><G><V><F><R><G><I><Q><D><V><R><R><V><P><G><V><A><P><T><L><V><R><S><A><S><E><T><S><E><K><R><P><F><M><C><A><Y><P><G><C><N><K><R><Y><F><K><L><S><H><L><Q><M><H><S><R><K><H><T><G><E><K><P><Y><Q><C><D><F><K><D><C><E><R><R><F><S><R><S><D><Q><L><K><R><H><Q><R><R><H><T><G><V><K><P><F><Q><C><K><T><C><Q><R><K><F><S><R><S><D><H><L><K><T><H><T><R><T><H><T><G><K><T><S><E><K><P><F><S><C><R><W><P><S><C><Q><K><K><F><A><R><S><D><E><L><V><R><H><H><N><M><H><Q><R><N><M><T><K><L><Q><L><A><L> | Transcription factor that plays an important role in cellular development and cell survival . Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' . Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors . Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing . Isoform 1 has lower affinity for DNA, and can bind RNA .<BOP> | P19544 |
Q3SXZ7 | TTLL9_HUMAN | Tubulin--tyrosine ligase-like protein 9 | Homo | <M><V><P><S><R><E><A><L><L><G><P><G><T><T><A><I><R><C><P><K><K><L><Q><N><Q><N><Y><K><G><H><G><L><S><K><G><K><E><R><E><Q><R><A><S><I><R><F><K><T><T><L><M><N><T><L><M><D><V><L><R><H><R><P><G><W><V><E><V><K><D><E><G><E><W><D><F><Y><W><C><D><V><S><W><L><R><E><N><F><D><H><T><Y><M><D><E><H><V><R><I><S><H><F><R><N><H><Y><E><L><T><R><K><N><Y><M><V><K><N><L><K><R><F><R><K><Q><L><E><R><E><A><G><K><L><E><A><A><K><C><D><F><F><P><K><T><F><E><M><P><C><E><Y><H><L><F><V><E><E><F><R><K><N><P><G><I><T><W><I><M><K><P><V><A><R><S><Q><G><K><G><I><F><L><F><R><R><L><K><D><I><V><D><W><R><K><D><T><R><S><S><D><D><Q><K><D><D><I><P><V><E><N><Y><V><A><Q><R><Y><I><E><N><P><Y><L><I><G><G><R><K><F><D><L><R><V><Y><V><L><V><M><S><V><F><A><E><C><L><L><W><S><G><H><R><R><Q><D><V><H><L><T><N><V><A><V><Q><K><T><S><P><D><Y><H><P><K><K><G><C><K><W><T><L><Q><R><F><R><Q><Y><L><A><S><K><H><G><P><E><A><V><E><T><L><F><R><D><I><D><N><I><F><V><K><S><L><Q><S><V><Q><K><V><I><I><S><D><K><H><C><F><E><L><Y><G><Y><D><I><L><I><D><Q><D><L><K><P><W><L><L><E><V><N><A><S><P><S><L><T><A><S><S><Q><E><D><Y><E><L><K><T><C><L><L><E><D><T><L><H><V><V><D><M><E><A><R><L><T><G><R><E><K><R><V><G><G><F><D><L><M><W><N><D><G><P><V><S><R><E><E><G><A><P><D><L><S><G><M><G><N><F><V><T><N><T><H><L><G><C><V><N><D><R><K><K><Q><L><R><Q><L><F><C><S><L><Q><V><Q><K><K><A><S><S> | Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins. Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity. Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern.<BOP> | Q3SXZ7 |
P54750 | PDE1A_HUMAN | hCam-1 | Homo | <M><G><S><S><A><T><E><I><E><E><L><E><N><T><T><F><K><Y><L><T><G><E><Q><T><E><K><M><W><Q><R><L><K><G><I><L><R><C><L><V><K><Q><L><E><R><G><D><V><N><V><V><D><L><K><K><N><I><E><Y><A><A><S><V><L><E><A><V><Y><I><D><E><T><R><R><L><L><D><T><E><D><E><L><S><D><I><Q><T><D><S><V><P><S><E><V><R><D><W><L><A><S><T><F><T><R><K><M><G><M><T><K><K><K><P><E><E><K><P><K><F><R><S><I><V><H><A><V><Q><A><G><I><F><V><E><R><M><Y><R><K><T><Y><H><M><V><G><L><A><Y><P><A><A><V><I><V><T><L><K><D><V><D><K><W><S><F><D><V><F><A><L><N><E><A><S><G><E><H><S><L><K><F><M><I><Y><E><L><F><T><R><Y><D><L><I><N><R><F><K><I><P><V><S><C><L><I><T><F><A><E><A><L><E><V><G><Y><S><K><Y><K><N><P><Y><H><N><L><I><H><A><A><D><V><T><Q><T><V><H><Y><I><M><L><H><T><G><I><M><H><W><L><T><E><L><E><I><L><A><M><V><F><A><A><A><I><H><D><Y><E><H><T><G><T><T><N><N><F><H><I><Q><T><R><S><D><V><A><I><L><Y><N><D><R><S><V><L><E><N><H><H><V><S><A><A><Y><R><L><M><Q><E><E><E><M><N><I><L><I><N><L><S><K><D><D><W><R><D><L><R><N><L><V><I><E><M><V><L><S><T><D><M><S><G><H><F><Q><Q><I><K><N><I><R><N><S><L><Q><Q><P><E><G><I><D><R><A><K><T><M><S><L><I><L><H><A><A><D><I><S><H><P><A><K><S><W><K><L><H><Y><R><W><T><M><A><L><M><E><E><F><F><L><Q><G><D><K><E><A><E><L><G><L><P><F><S><P><L><C><D><R><K><S><T><M><V><A><Q><S><Q><I><G><F><I><D><F><I><V><E><P><T><F><S><L><L><T><D><S><T><E><K><I><V><I><P><L><I><E><E><A><S><K><A><E><T><S><S><Y><V><A><S><S><S><T><T><I><V><G><L><H><I><A><D><A><L><R><R><S><N><T><K><G><S><M><S><D><G><S><Y><S><P><D><Y><S><L><A><A><V><D><L><K><S><F><K><N><N><L><V><D><I><I><Q><Q><N><K><E><R><W><K><E><L><A><A><Q><E><A><R><T><S><S><Q><K><C><E><F><I><H><Q> | Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP.<BOP> | P54750 |
P48201 | AT5G3_HUMAN | ATPase subunit c | Homo | <M><F><A><C><A><K><L><A><C><T><P><S><L><I><R><A><G><S><R><V><A><Y><R><P><I><S><A><S><V><L><S><R><P><E><A><S><R><T><G><E><G><S><T><V><F><N><G><A><Q><N><G><V><S><Q><L><I><Q><R><E><F><Q><T><S><A><I><S><R><D><I><D><T><A><A><K><F><I><G><A><G><A><A><T><V><G><V><A><G><S><G><A><G><I><G><T><V><F><G><S><L><I><I><G><Y><A><R><N><P><S><L><K><Q><Q><L><F><S><Y><A><I><L><G><F><A><L><S><E><A><M><G><L><F><C><L><M><V><A><F><L><I><L><F><A><M> | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.<BOP> | P48201 |
Q86XT4 | TRI50_HUMAN | Tripartite motif-containing protein 50 | Homo | <M><A><W><Q><V><S><L><P><E><L><E><D><R><L><Q><C><P><I><C><L><E><V><F><K><E><P><L><M><L><Q><C><G><H><S><Y><C><K><G><C><L><V><S><L><S><C><H><L><D><A><E><L><R><C><P><V><C><R><Q><A><V><D><G><S><S><S><L><P><N><V><S><L><A><R><V><I><E><A><L><R><L><P><G><D><P><E><P><K><V><C><V><H><H><R><N><P><L><S><L><F><C><E><K><D><Q><E><L><I><C><G><L><C><G><L><L><G><S><H><Q><H><H><P><V><T><P><V><S><T><V><Y><S><R><M><K><E><E><L><A><A><L><I><S><E><L><K><Q><E><Q><K><K><V><D><E><L><I><A><K><L><V><N><N><R><T><R><I><V><N><E><S><D><V><F><S><W><V><I><R><R><E><F><Q><E><L><H><H><L><V><D><E><E><K><A><R><C><L><E><G><I><G><G><H><T><R><G><L><V><A><S><L><D><M><Q><L><E><Q><A><Q><G><T><R><E><R><L><A><Q><A><E><C><V><L><E><Q><F><G><N><E><D><H><H><K><F><I><R><K><F><H><S><M><A><S><R><A><E><M><P><Q><A><R><P><L><E><G><A><F><S><P><I><S><F><K><P><G><L><H><Q><A><D><I><K><L><T><V><W><K><R><L><F><R><K><V><L><P><A><P><E><P><L><K><L><D><P><A><T><A><H><P><L><L><E><L><S><K><G><N><T><V><V><Q><C><G><L><L><A><Q><R><R><A><S><Q><P><E><R><F><D><Y><S><T><C><V><L><A><S><R><G><F><S><C><G><R><H><Y><W><E><V><V><V><G><S><K><S><D><W><R><L><G><V><I><K><G><T><A><S><R><K><G><K><L><N><R><S><P><E><H><G><V><W><L><I><G><L><K><E><G><R><V><Y><E><A><F><A><C><P><R><V><P><L><P><V><A><G><H><P><H><R><I><G><L><Y><L><H><Y><E><Q><G><E><L><T><F><F><D><A><D><R><P><D><D><L><R><P><L><Y><T><F><Q><A><D><F><Q><G><K><L><Y><P><I><L><D><T><C><W><H><E><R><G><S><N><S><L><P><M><V><L><P><P><P><S><G><P><G><P><L><S><P><E><Q><P><T><K><L> | E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction.<BOP> | Q86XT4 |
Q9NPA0 | EMC7_HUMAN | ER membrane protein complex subunit 7 | Homo | <M><A><A><A><L><W><G><F><F><P><V><L><L><L><L><L><L><S><G><D><V><Q><S><S><E><V><P><G><A><A><A><E><G><S><G><G><S><G><V><G><I><G><D><R><F><K><I><E><G><R><A><V><V><P><G><V><K><P><Q><D><W><I><S><A><A><R><V><L><V><D><G><E><E><H><V><G><F><L><K><T><D><G><S><F><V><V><H><D><I><P><S><G><S><Y><V><V><E><V><V><S><P><A><Y><R><F><D><P><V><R><V><D><I><T><S><K><G><K><M><R><A><R><Y><V><N><Y><I><K><T><S><E><V><V><R><L><P><Y><P><L><Q><M><K><S><S><G><P><P><S><Y><F><I><K><R><E><S><W><G><W><T><D><F><L><M><N><P><M><V><M><M><M><V><L><P><L><L><I><F><V><L><L><P><K><V><V><N><T><S><D><P><D><M><R><R><E><M><E><Q><S><M><N><M><L><N><S><N><H><E><L><P><D><V><S><E><F><M><T><R><L><F><S><S><K><S><S><G><K><S><S><S><G><S><S><K><T><G><K><S><G><A><G><K><R><R> | Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins . Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues . Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices . It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes . By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors . By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).<BOP> | Q9NPA0 |
Q96S86 | HPLN3_HUMAN | Hyaluronan and proteoglycan link protein 3 | Homo | <M><G><L><L><L><L><V><P><L><L><L><L><P><G><S><Y><G><L><P><F><Y><N><G><F><Y><Y><S><N><S><A><N><D><Q><N><L><G><N><G><H><G><K><D><L><L><N><G><V><K><L><V><V><E><T><P><E><E><T><L><F><T><Y><Q><G><A><S><V><I><L><P><C><R><Y><R><Y><E><P><A><L><V><S><P><R><R><V><R><V><K><W><W><K><L><S><E><N><G><A><P><E><K><D><V><L><V><A><I><G><L><R><H><R><S><F><G><D><Y><Q><G><R><V><H><L><R><Q><D><K><E><H><D><V><S><L><E><I><Q><D><L><R><L><E><D><Y><G><R><Y><R><C><E><V><I><D><G><L><E><D><E><S><G><L><V><E><L><E><L><R><G><V><V><F><P><Y><Q><S><P><N><G><R><Y><Q><F><N><F><H><E><G><Q><Q><V><C><A><E><Q><A><A><V><V><A><S><F><E><Q><L><F><R><A><W><E><E><G><L><D><W><C><N><A><G><W><L><Q><D><A><T><V><Q><Y><P><I><M><L><P><R><Q><P><C><G><G><P><G><L><A><P><G><V><R><S><Y><G><P><R><H><R><R><L><H><R><Y><D><V><F><C><F><A><T><A><L><K><G><R><V><Y><Y><L><E><H><P><E><K><L><T><L><T><E><A><R><E><A><C><Q><E><D><D><A><T><I><A><K><V><G><Q><L><F><A><A><W><K><F><H><G><L><D><R><C><D><A><G><W><L><A><D><G><S><V><R><Y><P><V><V><H><P><H><P><N><C><G><P><P><E><P><G><V><R><S><F><G><F><P><D><P><Q><S><R><L><Y><G><V><Y><C><Y><R><Q><H> | May function in hyaluronic acid binding.<BOP> | Q96S86 |
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