accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q8NG84
O2AK2_HUMAN
Olfactory receptor OR1-47
Homo
<M><N><I><S><D><V><I><S><F><D><I><L><V><S><A><M><K><T><G><N><Q><S><F><G><T><D><F><L><L><V><G><L><F><Q><Y><G><W><I><N><S><L><L><F><V><V><I><A><T><L><F><T><V><A><L><T><G><N><I><M><L><I><H><L><I><R><L><N><T><R><L><H><T><P><M><Y><F><L><L><S><Q><L><S><I><V><D><L><M><Y><I><S><T><T><V><P><K><M><A><V><S><F><L><S><Q><S><K><T><I><R><F><L><G><C><E><I><Q><T><Y><V><F><L><A><L><G><G><T><E><A><L><L><L><G><F><M><S><Y><D><R><Y><V><A><I><C><H><P><L><H><Y><P><M><L><M><S><K><K><I><C><C><L><M><V><A><C><A><W><A><S><G><S><I><N><A><F><I><H><T><L><Y><V><F><Q><L><P><F><C><R><S><R><L><I><N><H><F><F><C><E><V><P><A><L><L><S><L><V><C><Q><D><T><S><Q><Y><E><Y><T><V><L><L><S><G><L><I><I><L><L><L><P><F><L><A><I><L><A><S><Y><A><R><V><L><I><V><V><F><Q><M><S><S><G><K><G><Q><A><K><A><V><S><T><C><S><S><H><L><I><V><A><S><L><F><Y><A><T><T><L><F><T><Y><T><R><P><H><S><L><R><S><P><S><R><D><K><A><V><A><V><F><Y><T><I><V><T><P><L><L><N><P><F><I><Y><S><L><R><N><K><E><V><T><G><A><V><R><R><L><L><G><Y><W><I><C><C><R><K><Y><D><F><R><S><L><Y>
Odorant receptor.<BOP>
Q8NG84
Q15118
PDK1_HUMAN
Pyruvate dehydrogenase kinase isoform 1
Homo
<M><R><L><A><R><L><L><R><G><A><A><L><A><G><P><G><P><G><L><R><A><A><G><F><S><R><S><F><S><S><D><S><G><S><S><P><A><S><E><R><G><V><P><G><Q><V><D><F><Y><A><R><F><S><P><S><P><L><S><M><K><Q><F><L><D><F><G><S><V><N><A><C><E><K><T><S><F><M><F><L><R><Q><E><L><P><V><R><L><A><N><I><M><K><E><I><S><L><L><P><D><N><L><L><R><T><P><S><V><Q><L><V><Q><S><W><Y><I><Q><S><L><Q><E><L><L><D><F><K><D><K><S><A><E><D><A><K><A><I><Y><D><F><T><D><T><V><I><R><I><R><N><R><H><N><D><V><I><P><T><M><A><Q><G><V><I><E><Y><K><E><S><F><G><V><D><P><V><T><S><Q><N><V><Q><Y><F><L><D><R><F><Y><M><S><R><I><S><I><R><M><L><L><N><Q><H><S><L><L><F><G><G><K><G><K><G><S><P><S><H><R><K><H><I><G><S><I><N><P><N><C><N><V><L><E><V><I><K><D><G><Y><E><N><A><R><R><L><C><D><L><Y><Y><I><N><S><P><E><L><E><L><E><E><L><N><A><K><S><P><G><Q><P><I><Q><V><V><Y><V><P><S><H><L><Y><H><M><V><F><E><L><F><K><N><A><M><R><A><T><M><E><H><H><A><N><R><G><V><Y><P><P><I><Q><V><H><V><T><L><G><N><E><D><L><T><V><K><M><S><D><R><G><G><G><V><P><L><R><K><I><D><R><L><F><N><Y><M><Y><S><T><A><P><R><P><R><V><E><T><S><R><A><V><P><L><A><G><F><G><Y><G><L><P><I><S><R><L><Y><A><Q><Y><F><Q><G><D><L><K><L><Y><S><L><E><G><Y><G><T><D><A><V><I><Y><I><K><A><L><S><T><D><S><I><E><R><L><P><V><Y><N><K><A><A><W><K><H><Y><N><T><N><H><E><A><D><D><W><C><V><P><S><R><E><P><K><D><M><T><T><F><R><S><A>
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.<BOP>
Q15118
Q96RJ0
TAAR1_HUMAN
Trace amine-associated receptor 1
Homo
<M><M><P><F><C><H><N><I><I><N><I><S><C><V><K><N><N><W><S><N><D><V><R><A><S><L><Y><S><L><M><V><L><I><I><L><T><T><L><V><G><N><L><I><V><I><V><S><I><S><H><F><K><Q><L><H><T><P><T><N><W><L><I><H><S><M><A><T><V><D><F><L><L><G><C><L><V><M><P><Y><S><M><V><R><S><A><E><H><C><W><Y><F><G><E><V><F><C><K><I><H><T><S><T><D><I><M><L><S><S><A><S><I><F><H><L><S><F><I><S><I><D><R><Y><Y><A><V><C><D><P><L><R><Y><K><A><K><M><N><I><L><V><I><C><V><M><I><F><I><S><W><S><V><P><A><V><F><A><F><G><M><I><F><L><E><L><N><F><K><G><A><E><E><I><Y><Y><K><H><V><H><C><R><G><G><C><S><V><F><F><S><K><I><S><G><V><L><T><F><M><T><S><F><Y><I><P><G><S><I><M><L><C><V><Y><Y><R><I><Y><L><I><A><K><E><Q><A><R><L><I><S><D><A><N><Q><K><L><Q><I><G><L><E><M><K><N><G><I><S><Q><S><K><E><R><K><A><V><K><T><L><G><I><V><M><G><V><F><L><I><C><W><C><P><F><F><I><C><T><V><M><D><P><F><L><H><Y><I><I><P><P><T><L><N><D><V><L><I><W><F><G><Y><L><N><S><T><F><N><P><M><V><Y><A><F><F><Y><P><W><F><R><K><A><L><K><M><M><L><F><G><K><I><F><Q><K><D><S><S><R><C><K><L><F><L><E><L><S><S>
Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.<BOP>
Q96RJ0
Q96NY8
NECT4_HUMAN
Processed poliovirus receptor-related protein 4
Homo
<M><P><L><S><L><G><A><E><M><W><G><P><E><A><W><L><L><L><L><L><L><L><A><S><F><T><G><R><C><P><A><G><E><L><E><T><S><D><V><V><T><V><V><L><G><Q><D><A><K><L><P><C><F><Y><R><G><D><S><G><E><Q><V><G><Q><V><A><W><A><R><V><D><A><G><E><G><A><Q><E><L><A><L><L><H><S><K><Y><G><L><H><V><S><P><A><Y><E><G><R><V><E><Q><P><P><P><P><R><N><P><L><D><G><S><V><L><L><R><N><A><V><Q><A><D><E><G><E><Y><E><C><R><V><S><T><F><P><A><G><S><F><Q><A><R><L><R><L><R><V><L><V><P><P><L><P><S><L><N><P><G><P><A><L><E><E><G><Q><G><L><T><L><A><A><S><C><T><A><E><G><S><P><A><P><S><V><T><W><D><T><E><V><K><G><T><T><S><S><R><S><F><K><H><S><R><S><A><A><V><T><S><E><F><H><L><V><P><S><R><S><M><N><G><Q><P><L><T><C><V><V><S><H><P><G><L><L><Q><D><Q><R><I><T><H><I><L><H><V><S><F><L><A><E><A><S><V><R><G><L><E><D><Q><N><L><W><H><I><G><R><E><G><A><M><L><K><C><L><S><E><G><Q><P><P><P><S><Y><N><W><T><R><L><D><G><P><L><P><S><G><V><R><V><D><G><D><T><L><G><F><P><P><L><T><T><E><H><S><G><I><Y><V><C><H><V><S><N><E><F><S><S><R><D><S><Q><V><T><V><D><V><L><D><P><Q><E><D><S><G><K><Q><V><D><L><V><S><A><S><V><V><V><V><G><V><I><A><A><L><L><F><C><L><L><V><V><V><V><V><L><M><S><R><Y><H><R><R><K><A><Q><Q><M><T><Q><K><Y><E><E><E><L><T><L><T><R><E><N><S><I><R><R><L><H><S><H><H><T><D><P><R><S><Q><P><E><E><S><V><G><L><R><A><E><G><H><P><D><S><L><K><D><N><S><S><C><S><V><M><S><E><E><P><E><G><R><S><Y><S><T><L><T><T><V><R><E><I><E><T><Q><T><E><L><L><S><P><G><S><G><R><A><E><E><E><E><D><Q><D><E><G><I><K><Q><A><M><N><H><F><V><Q><E><N><G><T><L><R><A><K><P><T><G><N><G><I><Y><I><N><G><R><G><H><L><V>
(Microbial infection) Acts as a receptor for measles virus.<BOP>
Q96NY8
Q13316
DMP1_HUMAN
Dentin matrix acidic phosphoprotein 1
Homo
<M><K><I><S><I><L><L><M><F><L><W><G><L><S><C><A><L><P><V><T><R><Y><Q><N><N><E><S><E><D><S><E><E><W><K><G><H><L><A><Q><A><P><T><P><P><L><E><S><S><E><S><S><E><G><S><K><V><S><S><E><E><Q><A><N><E><D><P><S><D><S><T><Q><S><E><E><G><L><G><S><D><D><H><Q><Y><I><Y><R><L><A><G><G><F><S><R><S><T><G><K><G><G><D><D><K><D><D><D><E><D><D><S><G><D><D><T><F><G><D><D><D><S><G><P><G><P><K><D><R><Q><E><G><G><N><S><R><L><G><S><D><E><D><S><D><D><T><I><Q><A><S><E><E><S><A><P><Q><G><Q><D><S><A><Q><D><T><T><S><E><S><R><E><L><D><N><E><D><R><V><D><S><K><P><E><G><G><D><S><T><Q><E><S><E><S><E><E><H><W><V><G><G><G><S><D><G><E><S><S><H><G><D><G><S><E><L><D><D><E><G><M><Q><S><D><D><P><E><S><I><R><S><E><R><G><N><S><R><M><N><S><A><G><M><K><S><K><E><S><G><E><N><S><E><Q><A><N><T><Q><D><S><G><G><S><Q><L><L><E><H><P><S><R><K><I><F><R><K><S><R><I><S><E><E><D><D><R><S><E><L><D><D><N><N><T><M><E><E><V><K><S><D><S><T><E><N><S><N><S><R><D><T><G><L><S><Q><P><R><R><D><S><K><G><D><S><Q><E><D><S><K><E><N><L><S><Q><E><E><S><Q><N><V><D><G><P><S><S><E><S><S><Q><E><A><N><L><S><S><Q><E><N><S><S><E><S><Q><E><E><V><V><S><E><S><R><G><D><N><P><D><P><T><T><S><Y><V><E><D><Q><E><D><S><D><S><S><E><E><D><S><S><H><T><L><S><H><S><K><S><E><S><R><E><E><Q><A><D><S><E><S><S><E><S><L><N><F><S><E><E><S><P><E><S><P><E><D><E><N><S><S><S><Q><E><G><L><Q><S><H><S><S><S><A><E><S><Q><S><E><E><S><H><S><E><E><D><D><S><D><S><Q><D><S><S><R><S><K><E><D><S><N><S><T><E><S><K><S><S><S><E><E><D><G><Q><L><K><N><I><E><I><E><S><R><K><L><T><V><D><A><Y><H><N><K><P><I><G><D><Q><D><D><N><D><C><Q><D><G><Y>
May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.<BOP>
Q13316
Q5TKA1
LIN9_HUMAN
pRB-associated protein
Homo
<M><A><E><L><D><Q><L><P><D><E><S><S><S><A><K><A><L><V><S><L><K><E><G><S><L><S><N><T><W><N><E><K><Y><S><S><L><Q><K><T><P><V><W><K><G><R><N><T><S><S><A><V><E><M><P><F><R><N><S><K><R><S><R><L><F><S><D><E><D><D><R><Q><I><N><T><R><S><P><K><R><N><Q><R><V><A><M><V><P><Q><K><F><T><A><T><M><S><T><P><D><K><K><A><S><Q><K><I><G><F><R><L><R><N><L><L><K><L><P><K><A><H><K><W><C><I><Y><E><W><F><Y><S><N><I><D><K><P><L><F><E><G><D><N><D><F><C><V><C><L><K><E><S><F><P><N><L><K><T><R><K><L><T><R><V><E><W><G><K><I><R><R><L><M><G><K><P><R><R><C><S><S><A><F><F><E><E><E><R><S><A><L><K><Q><K><R><Q><K><I><R><L><L><Q><Q><R><K><V><A><D><V><S><Q><F><K><D><L><P><D><E><I><P><L><P><L><V><I><G><T><K><V><T><A><R><L><R><G><V><H><D><G><L><F><T><G><Q><I><D><A><V><D><T><L><N><A><T><Y><R><V><T><F><D><R><T><G><L><G><T><H><T><I><P><D><Y><E><V><L><S><N><E><P><H><E><T><M><P><I><A><A><F><G><Q><K><Q><R><P><S><R><F><F><M><T><P><P><R><L><H><Y><T><P><P><L><Q><S><P><I><I><D><N><D><P><L><L><G><Q><S><P><W><R><S><K><I><S><G><S><D><T><E><T><L><G><G><F><P><V><E><F><L><I><Q><V><T><R><L><S><K><I><L><M><I><K><K><E><H><I><K><K><L><R><E><M><N><T><E><A><E><K><L><K><S><Y><S><M><P><I><S><I><E><F><Q><R><R><Y><A><T><I><V><L><E><L><E><Q><L><N><K><D><L><N><K><V><L><H><K><V><Q><Q><Y><C><Y><E><L><A><P><D><Q><G><L><Q><P><A><D><Q><P><T><D><M><R><R><R><C><E><E><E><A><Q><E><I><V><R><H><A><N><S><S><T><G><Q><P><C><V><E><N><E><N><L><T><D><L><I><S><R><L><T><A><I><L><L><Q><I><K><C><L><A><E><G><G><D><L><N><S><F><E><F><K><S><L><T><D><S><L><N><D><I><K><S><T><I><D><A><S><N><I><S><C><F><Q><N><N><V><E><I><H><V><A><H><I><Q><S><G><L><S><Q><M><G><N><L><H><A><F><A><A><N><N><T><N><R><D>
Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.<BOP>
Q5TKA1
Q8NHS3
MFSD8_HUMAN
Ceroid-lipofuscinosis neuronal protein 7
Homo
<M><A><G><L><R><N><E><S><E><Q><E><P><L><L><G><D><T><P><G><S><R><E><W><D><I><L><E><T><E><E><H><Y><K><S><R><W><R><S><I><R><I><L><Y><L><T><M><F><L><S><S><V><G><F><S><V><V><M><M><S><I><W><P><Y><L><Q><K><I><D><P><T><A><D><T><S><F><L><G><W><V><I><A><S><Y><S><L><G><Q><M><V><A><S><P><I><F><G><L><W><S><N><Y><R><P><R><K><E><P><L><I><V><S><I><L><I><S><V><A><A><N><C><L><Y><A><Y><L><H><I><P><A><S><H><N><K><Y><Y><M><L><V><A><R><G><L><L><G><I><G><A><G><N><V><A><V><V><R><S><Y><T><A><G><A><T><S><L><Q><E><R><T><S><S><M><A><N><I><S><M><C><Q><A><L><G><F><I><L><G><P><V><F><Q><T><C><F><T><F><L><G><E><K><G><V><T><W><D><V><I><K><L><Q><I><N><M><Y><T><T><P><V><L><L><S><A><F><L><G><I><L><N><I><I><L><I><L><A><I><L><R><E><H><R><V><D><D><S><G><R><Q><C><K><S><I><N><F><E><E><A><S><T><D><E><A><Q><V><P><Q><G><N><I><D><Q><V><A><V><V><A><I><N><V><L><F><F><V><T><L><F><I><F><A><L><F><E><T><I><I><T><P><L><T><M><D><M><Y><A><W><T><Q><E><Q><A><V><L><Y><N><G><I><I><L><A><A><L><G><V><E><A><V><V><I><F><L><G><V><K><L><L><S><K><K><I><G><E><R><A><I><L><L><G><G><L><I><V><V><W><V><G><F><F><I><L><L><P><W><G><N><Q><F><P><K><I><Q><W><E><D><L><H><N><N><S><I><P><N><T><T><F><G><E><I><I><I><G><L><W><K><S><P><M><E><D><D><N><E><R><P><T><G><C><S><I><E><Q><A><W><C><L><Y><T><P><V><I><H><L><A><Q><F><L><T><S><A><V><L><I><G><L><G><Y><P><V><C><N><L><M><S><Y><T><L><Y><S><K><I><L><G><P><K><P><Q><G><V><Y><M><G><W><L><T><A><S><G><S><G><A><R><I><L><G><P><M><F><I><S><Q><V><Y><A><H><W><G><P><R><W><A><F><S><L><V><C><G><I><I><V><L><T><I><T><L><L><G><V><V><Y><K><R><L><I><A><L><S><V><R><Y><G><R><I><Q><E>
May be a carrier that transport small solutes by using chemiosmotic ion gradients.<BOP>
Q8NHS3
P23416
GLRA2_HUMAN
Glycine receptor subunit alpha-2
Homo
<M><N><R><Q><L><V><N><I><L><T><A><L><F><A><F><F><L><E><T><N><H><F><R><T><A><F><C><K><D><H><D><S><R><S><G><K><Q><P><S><Q><T><L><S><P><S><D><F><L><D><K><L><M><G><R><T><S><G><Y><D><A><R><I><R><P><N><F><K><G><P><P><V><N><V><T><C><N><I><F><I><N><S><F><G><S><V><T><E><T><T><M><D><Y><R><V><N><I><F><L><R><Q><Q><W><N><D><S><R><L><A><Y><S><E><Y><P><D><D><S><L><D><L><D><P><S><M><L><D><S><I><W><K><P><D><L><F><F><A><N><E><K><G><A><N><F><H><D><V><T><T><D><N><K><L><L><R><I><S><K><N><G><K><V><L><Y><S><I><R><L><T><L><T><L><S><C><P><M><D><L><K><N><F><P><M><D><V><Q><T><C><T><M><Q><L><E><S><F><G><Y><T><M><N><D><L><I><F><E><W><L><S><D><G><P><V><Q><V><A><E><G><L><T><L><P><Q><F><I><L><K><E><E><K><E><L><G><Y><C><T><K><H><Y><N><T><G><K><F><T><C><I><E><V><K><F><H><L><E><R><Q><M><G><Y><Y><L><I><Q><M><Y><I><P><S><L><L><I><V><I><L><S><W><V><S><F><W><I><N><M><D><A><A><P><A><R><V><A><L><G><I><T><T><V><L><T><M><T><T><Q><S><S><G><S><R><A><S><L><P><K><V><S><Y><V><K><A><I><D><I><W><M><A><V><C><L><L><F><V><F><A><A><L><L><E><Y><A><A><V><N><F><V><S><R><Q><H><K><E><F><L><R><L><R><R><R><Q><K><R><Q><N><K><E><E><D><V><T><R><E><S><R><F><N><F><S><G><Y><G><M><G><H><C><L><Q><V><K><D><G><T><A><V><K><A><T><P><A><N><P><L><P><Q><P><P><K><D><G><D><A><I><K><K><K><F><V><D><R><A><K><R><I><D><T><I><S><R><A><A><F><P><L><A><F><L><I><F><N><I><F><Y><W><I><T><Y><K><I><I><R><H><E><D><V><H><K><K>
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine . Channel opening is also triggered by taurine and beta-alanine . Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents . Plays a role in cellular responses to ethanol .<BOP>
P23416
O95563
MPC2_HUMAN
Brain protein 44
Homo
<M><S><A><A><G><A><R><G><L><R><A><T><Y><H><R><L><L><D><K><V><E><L><M><L><P><E><K><L><R><P><L><Y><N><H><P><A><G><P><R><T><V><F><F><W><A><P><I><M><K><W><G><L><V><C><A><G><L><A><D><M><A><R><P><A><E><K><L><S><T><A><Q><S><A><V><L><M><A><T><G><F><I><W><S><R><Y><S><L><V><I><I><P><K><N><W><S><L><F><A><V><N><F><F><V><G><A><A><G><A><S><Q><L><F><R><I><W><R><Y><N><Q><E><L><K><A><K><A><H><K>
Mediates the uptake of pyruvate into mitochondria.<BOP>
O95563
P17706
PTN2_HUMAN
T-cell protein-tyrosine phosphatase
Homo
<M><P><T><T><I><E><R><E><F><E><E><L><D><T><Q><R><R><W><Q><P><L><Y><L><E><I><R><N><E><S><H><D><Y><P><H><R><V><A><K><F><P><E><N><R><N><R><N><R><Y><R><D><V><S><P><Y><D><H><S><R><V><K><L><Q><N><A><E><N><D><Y><I><N><A><S><L><V><D><I><E><E><A><Q><R><S><Y><I><L><T><Q><G><P><L><P><N><T><C><C><H><F><W><L><M><V><W><Q><Q><K><T><K><A><V><V><M><L><N><R><I><V><E><K><E><S><V><K><C><A><Q><Y><W><P><T><D><D><Q><E><M><L><F><K><E><T><G><F><S><V><K><L><L><S><E><D><V><K><S><Y><Y><T><V><H><L><L><Q><L><E><N><I><N><S><G><E><T><R><T><I><S><H><F><H><Y><T><T><W><P><D><F><G><V><P><E><S><P><A><S><F><L><N><F><L><F><K><V><R><E><S><G><S><L><N><P><D><H><G><P><A><V><I><H><C><S><A><G><I><G><R><S><G><T><F><S><L><V><D><T><C><L><V><L><M><E><K><G><D><D><I><N><I><K><Q><V><L><L><N><M><R><K><Y><R><M><G><L><I><Q><T><P><D><Q><L><R><F><S><Y><M><A><I><I><E><G><A><K><C><I><K><G><D><S><S><I><Q><K><R><W><K><E><L><S><K><E><D><L><S><P><A><F><D><H><S><P><N><K><I><M><T><E><K><Y><N><G><N><R><I><G><L><E><E><E><K><L><T><G><D><R><C><T><G><L><S><S><K><M><Q><D><T><M><E><E><N><S><E><S><A><L><R><K><R><I><R><E><D><R><K><A><T><T><A><Q><K><V><Q><Q><M><K><Q><R><L><N><E><N><E><R><K><R><K><R><W><L><Y><W><Q><P><I><L><T><K><M><G><F><M><S><V><I><L><V><G><A><F><V><G><W><T><L><F><F><Q><Q><N><A><L>
Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and
P17706
Q15051
IQCB1_HUMAN
p53 and DNA damage-regulated IQ motif protein
Homo
<M><K><P><T><G><T><D><P><R><I><L><S><I><A><A><E><V><A><K><S><P><E><Q><N><V><P><V><I><L><L><K><L><K><E><I><I><N><I><T><P><L><G><S><S><E><L><K><K><I><K><Q><D><I><Y><C><Y><D><L><I><Q><Y><C><L><L><V><L><S><Q><D><Y><S><R><I><Q><G><G><W><T><T><I><S><Q><L><T><Q><I><L><S><H><C><C><V><G><L><E><P><G><E><D><A><E><E><F><Y><N><E><L><L><P><S><A><A><E><N><F><L><V><L><G><R><Q><L><Q><T><C><F><I><N><A><A><K><A><E><E><K><D><E><L><L><H><F><F><Q><I><V><T><D><S><L><F><W><L><L><G><G><H><V><E><L><I><Q><N><V><L><Q><S><D><H><F><L><H><L><L><Q><A><D><N><V><Q><I><G><S><A><V><M><M><M><L><Q><N><I><L><Q><I><N><S><G><D><L><L><R><I><G><R><K><A><L><Y><S><I><L><D><E><V><I><F><K><L><F><S><T><P><S><P><V><I><R><S><T><A><T><K><L><L><L><L><M><A><E><S><H><Q><E><I><L><I><L><L><R><Q><S><T><C><Y><K><G><L><R><R><L><L><S><K><Q><E><T><G><T><E><F><S><Q><E><L><R><Q><L><V><G><L><L><S><P><M><V><Y><Q><E><V><E><E><Q><K><L><H><Q><A><A><C><L><I><Q><A><Y><W><K><G><F><Q><T><R><K><R><L><K><K><L><P><S><A><V><I><A><L><Q><R><S><F><R><S><K><R><S><K><M><L><L><E><I><N><R><Q><K><E><E><E><D><L><K><L><Q><L><Q><L><Q><R><Q><R><A><M><R><L><S><R><E><L><Q><L><S><M><L><E><I><V><H><P><G><Q><V><E><K><H><Y><R><E><M><E><E><K><S><A><L><I><I><Q><K><H><W><R><G><Y><R><E><R><K><N><F><H><Q><Q><R><Q><S><L><I><E><Y><K><A><A><V><T><L><Q><R><A><A><L><K><F><L><A><K><C><R><K><K><K><K><L><F><A><P><W><R><G><L><Q><E><L><T><D><A><R><R><V><E><L><K><K><R><V><D><D><Y><V><R><R><H><L><G><S><P><M><S><D><V><V><S><R><E><L><H><A><Q><A><Q><E><R><L><Q><H><Y><F><M><G><R><A><L><E><E><R><A><Q><Q><H><R><E><A><L><I><A><Q><I><S><T><N><V><E><Q><L><M><K><A><P><S><L><K><E><A><E><G><K><E><P><E><L><F><L><S><R><S><R><P><V><A><A><K><A><K><Q><A><H><L><T><T><L><K><H><I><Q><A><P><W><W><K><K><L><G><E><E><S><G><D><E><I><D><V><P><K><D><E><L><S><I><E><L><E><N><L><F><I><G><G><T><K><P><P>
Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 . Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 .<BOP>
Q15051
Q8NGK3
O52K2_HUMAN
Olfactory receptor OR11-7
Homo
<M><S><A><S><N><I><T><L><T><H><P><T><A><F><L><L><V><G><I><P><G><L><E><H><L><H><I><W><I><S><I><P><F><C><L><A><Y><T><L><A><L><L><G><N><C><T><L><L><L><I><I><Q><A><D><A><A><L><H><E><P><M><Y><L><F><L><A><M><L><A><A><I><D><L><V><L><S><S><S><A><L><P><K><M><L><A><I><F><W><F><R><D><R><E><I><N><F><F><A><C><L><A><Q><M><F><F><L><H><S><F><S><I><M><E><S><A><V><L><L><A><M><A><F><D><R><Y><V><A><I><C><K><P><L><H><Y><T><K><V><L><T><G><S><L><I><T><K><I><G><M><A><A><V><A><R><A><V><T><L><M><T><P><L><P><F><L><L><R><C><F><H><Y><C><R><G><P><V><I><A><H><C><Y><C><E><H><M><A><V><V><R><L><A><C><G><D><T><S><F><N><N><I><Y><G><I><A><V><A><M><F><I><V><V><L><D><L><L><L><V><I><L><S><Y><I><F><I><L><Q><A><V><L><L><L><A><S><Q><E><A><R><Y><K><A><F><G><T><C><V><S><H><I><G><A><I><L><A><F><Y><T><T><V><V><I><S><S><V><M><H><R><V><A><R><H><A><A><P><H><V><H><I><L><L><A><N><F><Y><L><L><F><P><P><M><V><N><P><I><I><Y><G><V><K><T><K><Q><I><R><E><S><I><L><G><V><F><P><R><K><D><M>
Odorant receptor.<BOP>
Q8NGK3
P05362
ICAM1_HUMAN
Major group rhinovirus receptor
Homo
<M><A><P><S><S><P><R><P><A><L><P><A><L><L><V><L><L><G><A><L><F><P><G><P><G><N><A><Q><T><S><V><S><P><S><K><V><I><L><P><R><G><G><S><V><L><V><T><C><S><T><S><C><D><Q><P><K><L><L><G><I><E><T><P><L><P><K><K><E><L><L><L><P><G><N><N><R><K><V><Y><E><L><S><N><V><Q><E><D><S><Q><P><M><C><Y><S><N><C><P><D><G><Q><S><T><A><K><T><F><L><T><V><Y><W><T><P><E><R><V><E><L><A><P><L><P><S><W><Q><P><V><G><K><N><L><T><L><R><C><Q><V><E><G><G><A><P><R><A><N><L><T><V><V><L><L><R><G><E><K><E><L><K><R><E><P><A><V><G><E><P><A><E><V><T><T><T><V><L><V><R><R><D><H><H><G><A><N><F><S><C><R><T><E><L><D><L><R><P><Q><G><L><E><L><F><E><N><T><S><A><P><Y><Q><L><Q><T><F><V><L><P><A><T><P><P><Q><L><V><S><P><R><V><L><E><V><D><T><Q><G><T><V><V><C><S><L><D><G><L><F><P><V><S><E><A><Q><V><H><L><A><L><G><D><Q><R><L><N><P><T><V><T><Y><G><N><D><S><F><S><A><K><A><S><V><S><V><T><A><E><D><E><G><T><Q><R><L><T><C><A><V><I><L><G><N><Q><S><Q><E><T><L><Q><T><V><T><I><Y><S><F><P><A><P><N><V><I><L><T><K><P><E><V><S><E><G><T><E><V><T><V><K><C><E><A><H><P><R><A><K><V><T><L><N><G><V><P><A><Q><P><L><G><P><R><A><Q><L><L><L><K><A><T><P><E><D><N><G><R><S><F><S><C><S><A><T><L><E><V><A><G><Q><L><I><H><K><N><Q><T><R><E><L><R><V><L><Y><G><P><R><L><D><E><R><D><C><P><G><N><W><T><W><P><E><N><S><Q><Q><T><P><M><C><Q><A><W><G><N><P><L><P><E><L><K><C><L><K><D><G><T><F><P><L><P><I><G><E><S><V><T><V><T><R><D><L><E><G><T><Y><L><C><R><A><R><S><T><Q><G><E><V><T><R><K><V><T><V><N><V><L><S><P><R><Y><E><I><V><I><I><T><V><V><A><A><A><V><I><M><G><T><A><G><L><S><T><Y><L><Y><N><R><Q><R><K><I><K><K><Y><R><L><Q><Q><A><Q><K><G><T><P><M><K><P><N><T><Q><A><T><P><P>
(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.<BOP>
P05362
P06280
AGAL_HUMAN
Melibiase
Homo
<M><Q><L><R><N><P><E><L><H><L><G><C><A><L><A><L><R><F><L><A><L><V><S><W><D><I><P><G><A><R><A><L><D><N><G><L><A><R><T><P><T><M><G><W><L><H><W><E><R><F><M><C><N><L><D><C><Q><E><E><P><D><S><C><I><S><E><K><L><F><M><E><M><A><E><L><M><V><S><E><G><W><K><D><A><G><Y><E><Y><L><C><I><D><D><C><W><M><A><P><Q><R><D><S><E><G><R><L><Q><A><D><P><Q><R><F><P><H><G><I><R><Q><L><A><N><Y><V><H><S><K><G><L><K><L><G><I><Y><A><D><V><G><N><K><T><C><A><G><F><P><G><S><F><G><Y><Y><D><I><D><A><Q><T><F><A><D><W><G><V><D><L><L><K><F><D><G><C><Y><C><D><S><L><E><N><L><A><D><G><Y><K><H><M><S><L><A><L><N><R><T><G><R><S><I><V><Y><S><C><E><W><P><L><Y><M><W><P><F><Q><K><P><N><Y><T><E><I><R><Q><Y><C><N><H><W><R><N><F><A><D><I><D><D><S><W><K><S><I><K><S><I><L><D><W><T><S><F><N><Q><E><R><I><V><D><V><A><G><P><G><G><W><N><D><P><D><M><L><V><I><G><N><F><G><L><S><W><N><Q><Q><V><T><Q><M><A><L><W><A><I><M><A><A><P><L><F><M><S><N><D><L><R><H><I><S><P><Q><A><K><A><L><L><Q><D><K><D><V><I><A><I><N><Q><D><P><L><G><K><Q><G><Y><Q><L><R><Q><G><D><N><F><E><V><W><E><R><P><L><S><G><L><A><W><A><V><A><M><I><N><R><Q><E><I><G><G><P><R><S><Y><T><I><A><V><A><S><L><G><K><G><V><A><C><N><P><A><C><F><I><T><Q><L><L><P><V><K><R><K><L><G><F><Y><E><W><T><S><R><L><R><S><H><I><N><P><T><G><T><V><L><L><Q><L><E><N><T><M><Q><M><S><L><K><D><L><L>
Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.<BOP>
P06280
Q9UQF2
JIP1_HUMAN
Mitogen-activated protein kinase 8-interacting protein 1
Homo
<M><A><E><R><E><S><G><G><L><G><G><G><A><A><S><P><P><A><A><S><P><F><L><G><L><H><I><A><S><P><P><N><F><R><L><T><H><D><I><S><L><E><E><F><E><D><E><D><L><S><E><I><T><D><E><C><G><I><S><L><Q><C><K><D><T><L><S><L><R><P><P><R><A><G><L><L><S><A><G><G><G><G><A><G><S><R><L><Q><A><E><M><L><Q><M><D><L><I><D><A><T><G><D><T><P><G><A><E><D><D><E><E><D><D><D><E><E><R><A><A><R><R><P><G><A><G><P><P><K><A><E><S><G><Q><E><P><A><S><R><G><Q><G><Q><S><Q><G><Q><S><Q><G><P><G><S><G><D><T><Y><R><P><K><R><P><T><T><L><N><L><F><P><Q><V><P><R><S><Q><D><T><L><N><N><N><S><L><G><K><K><H><S><W><Q><D><R><V><S><R><S><S><S><P><L><K><T><G><E><Q><T><P><P><H><E><H><I><C><L><S><D><E><L><P><P><Q><S><G><P><A><P><T><T><D><R><G><T><S><T><D><S><P><C><R><R><S><T><A><T><Q><M><A><P><P><G><G><P><P><A><A><P><P><G><G><R><G><H><S><H><R><D><R><I><H><Y><Q><A><D><V><R><L><E><A><T><E><E><I><Y><L><T><P><V><Q><R><P><P><D><A><A><E><P><T><S><A><F><L><P><P><T><E><S><R><M><S><V><S><S><D><P><D><P><A><A><Y><P><S><T><A><G><R><P><H><P><S><I><S><E><E><E><E><G><F><D><C><L><S><S><P><E><R><A><E><P><P><G><G><G><W><R><G><S><L><G><E><P><P><P><P><P><R><A><S><L><S><S><D><T><S><A><L><S><Y><D><S><V><K><Y><T><L><V><V><D><E><H><A><Q><L><E><L><V><S><L><R><P><C><F><G><D><Y><S><D><E><S><D><S><A><T><V><Y><D><N><C><A><S><V><S><S><P><Y><E><S><A><I><G><E><E><Y><E><E><A><P><R><P><Q><P><P><A><C><L><S><E><D><S><T><P><D><E><P><D><V><H><F><S><K><K><F><L><N><V><F><M><S><G><R><S><R><S><S><S><A><E><S><F><G><L><F><S><C><I><I><N><G><E><E><Q><E><Q><T><H><R><A><I><F><R><F><V><P><R><H><E><D><E><L><E><L><E><V><D><D><P><L><L><V><E><L><Q><A><E><D><Y><W><Y><E><A><Y><N><M><R><T><G><A><R><G><V><F><P><A><Y><Y><A><I><E><V><T><K><E><P><E><H><M><A><A><L><A><K><N><S><D><W><V><D><Q><F><R><V><K><F><L><G><S><V><Q><V><P><Y><H><K><G><N><D><V><L><C><A><A><M><Q><K><I><A><T><T><R><R><L><T><V><H><F><N><P><P><S><S><C><V><L><E><I><S><V><R><G><V><K><I><G><V><K><A><D><D><S><Q><E><A><K><G><N><K><C><S><H><F><F><Q><L><K><N><I><S><F><C><G><Y><H><P><K><N><N><K><Y><F><G><F><I><T><K><H><P><A><D><H><R><F><A><C><H><V><F><V><S><E><D><S><T><K><A><L><A><E><S><V><G><R><A><F><Q><Q><F><Y><K><Q><F><V><E><Y><T><C><P><T><E><D><I><Y><L><E>
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure
Q9UQF2
Q9Y2V7
COG6_HUMAN
Component of oligomeric Golgi complex 6
Homo
<M><A><E><G><S><G><E><V><V><A><V><S><A><T><G><A><A><N><G><L><N><N><G><A><G><G><T><S><A><T><T><C><N><P><L><S><R><K><L><H><K><I><L><E><T><R><L><D><N><D><K><E><M><L><E><A><L><K><A><L><S><T><F><F><V><E><N><S><L><R><T><R><R><N><L><R><G><D><I><E><R><K><S><L><A><I><N><E><E><F><V><S><I><F><K><E><V><K><E><E><L><E><S><I><S><E><D><V><Q><A><M><S><N><C><C><Q><D><M><T><S><R><L><Q><A><A><K><E><Q><T><Q><D><L><I><V><K><T><T><K><L><Q><S><E><S><Q><K><L><E><I><R><A><Q><V><A><D><A><F><L><S><K><F><Q><L><T><S><D><E><M><S><L><L><R><G><T><R><E><G><P><I><T><E><D><F><F><K><A><L><G><R><V><K><Q><I><H><N><D><V><K><V><L><L><R><T><N><Q><Q><T><A><G><L><E><I><M><E><Q><M><A><L><L><Q><E><T><A><Y><E><R><L><Y><R><W><A><Q><S><E><C><R><T><L><T><Q><E><S><C><D><V><S><P><V><L><T><Q><A><M><E><A><L><Q><D><R><P><V><L><Y><K><Y><T><L><D><E><F><G><T><A><R><R><S><T><V><V><R><G><F><I><D><A><L><T><R><G><G><P><G><G><T><P><R><P><I><E><M><H><S><H><D><P><L><R><Y><V><G><D><M><L><A><W><L><H><Q><A><T><A><S><E><K><E><H><L><E><A><L><L><K><H><V><T><T><Q><G><V><E><E><N><I><Q><E><V><V><G><H><I><T><E><G><V><C><R><P><L><K><V><R><I><E><Q><V><I><V><A><E><P><G><A><V><L><L><Y><K><I><S><N><L><L><K><F><Y><H><H><T><I><S><G><I><V><G><N><S><A><T><A><L><L><T><T><I><E><E><M><H><L><L><S><K><K><I><F><F><N><S><L><S><L><H><A><S><K><L><M><D><K><V><E><L><P><P><P><D><L><G><P><S><S><A><L><N><Q><T><L><M><L><L><R><E><V><L><A><S><H><D><S><S><V><V><P><L><D><A><R><Q><A><D><F><V><Q><V><L><S><C><V><L><D><P><L><L><Q><M><C><T><V><S><A><S><N><L><G><T><A><D><M><A><T><F><M><V><N><S><L><Y><M><M><K><T><T><L><A><L><F><E><F><T><D><R><R><L><E><M><L><Q><F><Q><I><E><A><H><L><D><T><L><I><N><E><Q><A><S><Y><V><L><T><R><V><G><L><S><Y><I><Y><N><T><V><Q><Q><H><K><P><E><Q><G><S><L><A><N><M><P><N><L><D><S><V><T><L><K><A><A><M><V><Q><F><D><R><Y><L><S><A><P><D><N><L><L><I><P><Q><L><N><F><L><L><S><A><T><V><K><E><Q><I><V><K><Q><S><T><E><L><V><C><R><A><Y><G><E><V><Y><A><A><V><M><N><P><I><N><E><Y><K><D><P><E><N><I><L><H><R><S><P><Q><Q><V><Q><T><L><L><S>
Required for normal Golgi function.<BOP>
Q9Y2V7
P0DPK2
H3Y1_HUMAN
Histone H3.Y1
Homo
<M><A><R><T><K><Q><T><A><R><K><A><T><A><W><Q><A><P><R><K><P><L><A><T><K><A><A><G><K><R><A><P><P><T><G><G><I><K><K><P><H><R><Y><K><P><G><T><L><A><L><R><E><I><R><K><Y><Q><K><S><T><Q><L><L><L><R><K><L><P><F><Q><R><L><V><R><E><I><A><Q><A><I><S><P><D><L><R><F><Q><S><A><A><I><G><A><L><Q><E><A><S><E><A><Y><L><V><Q><L><F><E><D><T><N><L><C><A><I><H><A><R><R><V><T><I><M><P><R><D><M><Q><L><A><R><R><L><R><R><E><G><P>
Primate-specific variant histone H3, which constitutes a core component of nucleosomes . Histone H3.Y-containing nucleosomes accumulate around transcription start sites and have flexible DNA ends, suggesting that they form relaxed chromatin that allows transcription factor access . Histone H1 binds less efficiently to histone H3.Y-containing nucleosomes . Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (Probable).<BOP>
P0DPK2
Q96BR5
COA7_HUMAN
Sel1 repeat-containing protein 1
Homo
<M><A><G><M><V><D><F><Q><D><E><E><Q><V><K><S><F><L><E><N><M><E><V><E><C><N><Y><H><C><Y><H><E><K><D><P><D><G><C><Y><R><L><V><D><Y><L><E><G><I><R><K><N><F><D><E><A><A><K><V><L><K><F><N><C><E><E><N><Q><H><S><D><S><C><Y><K><L><G><A><Y><Y><V><T><G><K><G><G><L><T><Q><D><L><K><A><A><A><R><C><F><L><M><A><C><E><K><P><G><K><K><S><I><A><A><C><H><N><V><G><L><L><A><H><D><G><Q><V><N><E><D><G><Q><P><D><L><G><K><A><R><D><Y><Y><T><R><A><C><D><G><G><Y><T><S><S><C><F><N><L><S><A><M><F><L><Q><G><A><P><G><F><P><K><D><M><D><L><A><C><K><Y><S><M><K><A><C><D><L><G><H><I><W><A><C><A><N><A><S><R><M><Y><K><L><G><D><G><V><D><K><D><E><A><K><A><E><V><L><K><N><R><A><Q><Q><L><H><K><E><Q><Q><K><G><V><Q><P><L><T><F><G>
Required for assembly of mitochondrial respiratory chain complex I and complex IV.<BOP>
Q96BR5
Q9UBD5
ORC3_HUMAN
Origin recognition complex subunit Latheo
Homo
<M><A><T><S><S><M><S><K><G><C><F><V><F><K><P><N><S><K><K><R><K><I><S><L><P><I><E><D><Y><F><N><K><G><K><N><E><P><E><D><S><K><L><R><F><E><T><Y><Q><L><I><W><Q><Q><M><K><S><E><N><E><R><L><Q><E><E><L><N><K><N><L><F><D><N><L><I><E><F><L><Q><K><S><H><S><G><F><Q><K><N><S><R><D><L><G><G><Q><I><K><L><R><E><I><P><T><A><A><L><V><L><G><V><N><V><T><D><H><D><L><T><F><G><S><L><T><E><A><L><Q><N><N><V><T><P><Y><V><V><S><L><Q><A><K><D><C><P><D><M><K><H><F><L><Q><K><L><I><S><Q><L><M><D><C><C><V><D><I><K><S><K><E><E><E><S><V><H><V><T><Q><R><K><T><H><Y><S><M><D><S><L><S><S><W><Y><M><T><V><T><Q><K><T><D><P><K><M><L><S><K><K><R><T><T><S><S><Q><W><Q><S><P><P><V><V><V><I><L><K><D><M><E><S><F><A><T><K><V><L><Q><D><F><I><I><I><S><S><Q><H><L><H><E><F><P><L><I><L><I><F><G><I><A><T><S><P><I><I><I><H><R><L><L><P><H><A><V><S><S><L><L><C><I><E><L><F><Q><S><L><S><C><K><E><H><L><T><T><V><L><D><K><L><L><L><T><T><Q><F><P><F><K><I><N><E><K><V><L><Q><V><L><T><N><I><F><L><Y><H><D><F><S><V><Q><N><F><I><K><G><L><Q><L><S><L><L><E><H><F><Y><S><Q><P><L><S><V><L><C><C><N><L><P><E><A><K><R><R><I><N><F><L><S><N><N><Q><C><E><N><I><R><R><L><P><S><F><R><R><Y><V><E><K><Q><A><S><E><K><Q><V><A><L><L><T><N><E><R><Y><L><K><E><E><T><Q><L><L><L><E><N><L><H><V><Y><H><M><N><Y><F><L><V><L><R><C><L><H><K><F><T><S><S><L><P><K><Y><P><L><G><R><Q><I><R><E><L><Y><C><T><C><L><E><K><N><I><W><D><S><E><E><Y><A><S><V><L><Q><L><L><R><M><L><A><K><D><E><L><M><T><I><L><E><K><C><F><K><V><F><K><S><Y><C><E><N><H><L><G><S><T><A><K><R><I><E><E><F><L><A><Q><F><Q><S><L><D><E><T><K><E><E><E><D><A><S><G><S><Q><P><K><G><L><Q><K><T><D><L><Y><H><L><Q><K><S><L><L><E><M><K><E><L><R><R><S><K><K><Q><T><K><F><E><V><L><R><E><N><V><V><N><F><I><D><C><L><V><R><E><Y><L><L><P><P><E><T><Q><P><L><H><E><V><V><Y><F><S><A><A><H><A><L><R><E><H><L><N><A><A><P><R><I><A><L><H><T><A><L><N><N><P><Y><Y><Y><L><K><N><E><A><L><K><S><E><E><G><C><I><P><N><I><A><P><D><I><C><I><A><Y><K><L><H><L><E><C><S><R><L><I><N><L><V><D><W><S><E><A><F><A><T><V><V><T><A><A><E><K><M><D><A><N><S><A><T><S><E><E><M><N><E><I><I><H><A><R><F><I><R><A><V><S><E><L><E><L><L><G><F><I><K><P><T><K><Q><K><T><D><H><V><A><R><L><T><W><G><G><C>
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.<BOP>
Q9UBD5
Q8NHP8
PLBL2_HUMAN
Putative phospholipase B-like 2 45 kDa form
Homo
<M><V><G><Q><M><Y><C><Y><P><G><S><H><L><A><R><A><L><T><R><A><L><A><L><A><L><V><L><A><L><L><V><G><P><F><L><S><G><L><A><G><A><I><P><A><P><G><G><R><W><A><R><D><G><Q><V><P><P><A><S><R><S><R><S><V><L><L><D><V><S><A><G><Q><L><L><M><V><D><G><R><H><P><D><A><V><A><W><A><N><L><T><N><A><I><R><E><T><G><W><A><F><L><E><L><G><T><S><G><Q><Y><N><D><S><L><Q><A><Y><A><A><G><V><V><E><A><A><V><S><E><E><L><I><Y><M><H><W><M><N><T><V><V><N><Y><C><G><P><F><E><Y><E><V><G><Y><C><E><R><L><K><S><F><L><E><A><N><L><E><W><M><Q><E><E><M><E><S><N><P><D><S><P><Y><W><H><Q><V><R><L><T><L><L><Q><L><K><G><L><E><D><S><Y><E><G><R><V><S><F><P><A><G><K><F><T><I><K><P><L><G><F><L><L><L><Q><L><S><G><D><L><E><D><L><E><L><A><L><N><K><T><K><I><K><P><S><L><G><S><G><S><C><S><A><L><I><K><L><L><P><G><Q><S><D><L><L><V><A><H><N><T><W><N><N><Y><Q><H><M><L><R><V><I><K><K><Y><W><L><Q><F><R><E><G><P><W><G><D><Y><P><L><V><P><G><N><K><L><V><F><S><S><Y><P><G><T><I><F><S><C><D><D><F><Y><I><L><G><S><G><L><V><T><L><E><T><T><I><G><N><K><N><P><A><L><W><K><Y><V><R><P><R><G><C><V><L><E><W><V><R><N><I><V><A><N><R><L><A><S><D><G><A><T><W><A><D><I><F><K><R><F><N><S><G><T><Y><N><N><Q><W><M><I><V><D><Y><K><A><F><I><P><G><G><P><S><P><G><S><R><V><L><T><I><L><E><Q><I><P><G><M><V><V><V><A><D><K><T><S><E><L><Y><Q><K><T><Y><W><A><S><Y><N><I><P><S><F><E><T><V><F><N><A><S><G><L><Q><A><L><V><A><Q><Y><G><D><W><F><S><Y><D><G><S><P><R><A><Q><I><F><R><R><N><Q><S><L><V><Q><D><M><D><S><M><V><R><L><M><R><Y><N><D><F><L><H><D><P><L><S><L><C><K><A><C><N><P><Q><P><N><G><E><N><A><I><S><A><R><S><D><L><N><P><A><N><G><S><Y><P><F><Q><A><L><R><Q><R><S><H><G><G><I><D><V><K><V><T><S><M><S><L><A><R><I><L><S><L><L><A><A><S><G><P><T><W><D><Q><V><P><P><F><Q><W><S><T><S><P><F><S><G><L><L><H><M><G><Q><P><D><L><W><K><F><A><P><V><K><V><S><W><D>
Putative phospholipase.<BOP>
Q8NHP8
Q16851
UGPA_HUMAN
UDP-glucose pyrophosphorylase
Homo
<M><S><R><F><V><Q><D><L><S><K><A><M><S><Q><D><G><A><S><Q><F><Q><E><V><I><R><Q><E><L><E><L><S><V><K><K><E><L><E><K><I><L><T><T><A><S><S><H><E><F><E><H><T><K><K><D><L><D><G><F><R><K><L><F><H><R><F><L><Q><E><K><G><P><S><V><D><W><G><K><I><Q><R><P><P><E><D><S><I><Q><P><Y><E><K><I><K><A><R><G><L><P><D><N><I><S><S><V><L><N><K><L><V><V><V><K><L><N><G><G><L><G><T><S><M><G><C><K><G><P><K><S><L><I><G><V><R><N><E><N><T><F><L><D><L><T><V><Q><Q><I><E><H><L><N><K><T><Y><N><T><D><V><P><L><V><L><M><N><S><F><N><T><D><E><D><T><K><K><I><L><Q><K><Y><N><H><C><R><V><K><I><Y><T><F><N><Q><S><R><Y><P><R><I><N><K><E><S><L><L><P><V><A><K><D><V><S><Y><S><G><E><N><T><E><A><W><Y><P><P><G><H><G><D><I><Y><A><S><F><Y><N><S><G><L><L><D><T><F><I><G><E><G><K><E><Y><I><F><V><S><N><I><D><N><L><G><A><T><V><D><L><Y><I><L><N><H><L><M><N><P><P><N><G><K><R><C><E><F><V><M><E><V><T><N><K><T><R><A><D><V><K><G><G><T><L><T><Q><Y><E><G><K><L><R><L><V><E><I><A><Q><V><P><K><A><H><V><D><E><F><K><S><V><S><K><F><K><I><F><N><T><N><N><L><W><I><S><L><A><A><V><K><R><L><Q><E><Q><N><A><I><D><M><E><I><I><V><N><A><K><T><L><D><G><G><L><N><V><I><Q><L><E><T><A><V><G><A><A><I><K><S><F><E><N><S><L><G><I><N><V><P><R><S><R><F><L><P><V><K><T><T><S><D><L><L><L><V><M><S><N><L><Y><S><L><N><A><G><S><L><T><M><S><E><K><R><E><F><P><T><V><P><L><V><K><L><G><S><S><F><T><K><V><Q><D><Y><L><R><R><F><E><S><I><P><D><M><L><E><L><D><H><L><T><V><S><G><D><V><T><F><G><K><N><V><S><L><K><G><T><V><I><I><I><A><N><H><G><D><R><I><D><I><P><P><G><A><V><L><E><N><K><I><V><S><G><N><L><R><I><L><D><H>
UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.<BOP>
Q16851
P0DTW3
HV384_HUMAN
Probable non-functional immunoglobulin heavy variable 1-38-4
Homo
<M><D><W><N><W><R><I><L><F><L><V><V><A><T><T><G><A><H><S><Q><V><Q><L><V><Q><S><W><A><E><V><R><K><S><G><A><S><V><K><V><S><C><S><F><S><G><F><T><I><T><S><Y><G><I><H><W><V><Q><Q><S><P><G><Q><G><L><E><W><M><G><W><I><N><P><G><N><G><S><P><S><Y><A><K><K><F><Q><G><R><F><T><M><T><R><D><M><S><T><T><T><A><Y><T><D><L><S><S><L><T><S><E><D><M><A><V><Y><Y><Y><A><R>
Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains . Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection
P0DTW3
Q9H0M5
ZN700_HUMAN
Zinc finger protein 700
Homo
<M><P><C><C><S><H><R><S><C><R><E><D><P><G><T><S><E><S><R><E><M><D><P><V><A><F><E><D><V><A><V><N><F><T><Q><E><E><W><T><L><L><D><I><S><Q><K><N><L><F><R><E><V><M><L><E><T><F><R><N><L><T><S><I><G><K><K><W><S><D><Q><N><I><E><Y><E><Y><Q><N><P><R><R><S><F><R><S><L><I><E><E><K><V><N><E><I><K><E><D><S><H><C><G><E><T><F><T><Q><V><P><D><D><R><L><N><F><Q><E><K><K><A><S><P><E><V><K><S><C><D><S><F><V><C><A><E><V><G><I><G><N><S><S><F><N><M><S><I><R><G><D><T><G><H><K><A><Y><E><Y><Q><E><Y><G><P><K><P><Y><K><C><Q><Q><P><K><N><K><K><A><F><R><Y><R><P><S><I><R><T><Q><E><R><D><H><T><G><E><K><P><Y><A><C><K><V><C><G><K><T><F><I><F><H><S><S><I><R><R><H><M><V><M><H><S><G><D><G><T><Y><K><C><K><F><C><G><K><A><F><H><S><F><S><L><Y><L><I><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><S><F><T><Y><S><A><T><L><Q><I><H><E><R><T><H><T><G><E><K><P><Y><E><C><S><K><C><D><K><A><F><H><S><S><S><S><Y><H><R><H><E><R><S><H><M><G><E><K><P><Y><Q><C><K><E><C><G><K><A><F><A><Y><T><S><S><L><R><R><H><E><R><T><H><S><G><K><K><P><Y><E><C><K><Q><Y><G><E><G><L><S><Y><L><I><S><F><Q><T><H><I><R><M><N><S><G><E><R><P><Y><K><C><K><I><C><G><K><G><F><Y><S><A><K><S><F><Q><T><H><E><K><T><H><T><G><E><K><R><Y><K><C><K><Q><C><G><K><A><F><N><L><S><S><S><F><R><Y><H><E><R><I><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><R><S><A><S><Q><L><R><V><H><G><G><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><S><T><S><H><L><R><V><H><G><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><Y><V><K><H><L><Q><I><H><E><R><T><E><K><H><I><R><M><P><S><G><E><R><P><Y><K><C><S><I><C><E><K><G><F><Y><S><A><K><S><F><Q><T><H><E><K><T><H><T><G><E><K><P><Y><E><C><N><Q><C><G><K><A><F><R><C><C><N><S><L><R><Y><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><R><S><A><S><H><L><R><M><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><S><C><A><S><N><L><R><K><H><G><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><R><S><A><S><N><L><Q><M><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><E><K><A><F><C><K><F><S><S><F><Q><I><H><E><R><K><H><R><G><E><K><P><Y><E><C><K><H><C><G><N><G><F><T><S><A><K><I><L><Q><I><H><A><R><T><H><I><G><E><K><H><Y><E><C><K><E><C><G><K><A><F><N><Y><F><S><S><L><H><I><H><A><R><T><H><M><G><E><K><P><Y><E><C><K><D><C><G><K><A><F><S>
May be involved in transcriptional regulation.<BOP>
Q9H0M5
Q8NHY0
B4GN2_HUMAN
UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase
Homo
<M><G><S><A><G><F><S><V><G><K><F><H><V><E><V><A><S><R><G><R><E><C><V><S><G><T><P><E><C><G><N><R><L><G><S><A><G><F><G><A><L><C><L><E><L><R><G><A><D><P><A><W><G><P><F><A><A><H><G><R><S><R><R><Q><G><S><R><F><L><W><L><L><K><I><L><V><I><I><L><V><L><G><I><V><G><F><M><F><G><S><M><F><L><Q><A><V><F><S><S><P><K><P><E><L><P><S><P><A><P><G><V><Q><K><L><K><L><L><P><E><E><R><L><R><N><L><F><S><Y><D><G><I><W><L><F><P><K><N><Q><C><K><C><E><A><N><K><E><Q><G><G><Y><N><F><Q><D><A><Y><G><Q><S><D><L><P><A><V><K><A><R><R><Q><A><E><F><E><H><F><Q><R><R><E><G><L><P><R><P><L><P><L><L><V><Q><P><N><L><P><F><G><Y><P><V><H><G><V><E><V><M><P><L><H><T><V><P><I><P><G><L><Q><F><E><G><P><D><A><P><V><Y><E><V><T><L><T><A><S><L><G><T><L><N><T><L><A><D><V><P><D><S><V><V><Q><G><R><G><Q><K><Q><L><I><I><S><T><S><D><R><K><L><L><K><F><I><L><Q><H><V><T><Y><T><S><T><G><Y><Q><H><Q><K><V><D><I><V><S><L><E><S><R><S><S><V><A><K><F><P><V><T><I><R><H><P><V><I><P><K><L><Y><D><P><G><P><E><R><K><L><R><N><L><V><T><I><A><T><K><T><F><L><R><P><H><K><L><M><I><M><L><R><S><I><R><E><Y><Y><P><D><L><T><V><I><V><A><D><D><S><Q><K><P><L><E><I><K><D><N><H><V><E><Y><Y><T><M><P><F><G><K><G><W><F><A><G><R><N><L><A><I><S><Q><V><T><T><K><Y><V><L><W><V><D><D><D><F><L><F><N><E><E><T><K><I><E><V><L><V><D><V><L><E><K><T><E><L><D><V><V><G><G><S><V><L><G><N><V><F><Q><F><K><L><L><L><E><Q><S><E><N><G><A><C><L><H><K><R><M><G><F><F><Q><P><L><D><G><F><P><S><C><V><V><T><S><G><V><V><N><F><F><L><A><H><T><E><R><L><Q><R><V><G><F><D><P><R><L><Q><R><V><A><H><S><E><F><F><I><D><G><L><G><T><L><L><V><G><S><C><P><E><V><I><I><G><H><Q><S><R><S><P><V><V><D><S><E><L><A><A><L><E><K><T><Y><N><T><Y><R><S><N><T><L><T><R><V><Q><F><K><L><A><L><H><Y><F><K><N><H><L><Q><C><A><A>
Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain.<BOP>
Q8NHY0
P09669
COX6C_HUMAN
Cytochrome c oxidase polypeptide VIc
Homo
<M><A><P><E><V><L><P><K><P><R><M><R><G><L><L><A><R><R><L><R><N><H><M><A><V><A><F><V><L><S><L><G><V><A><A><L><Y><K><F><R><V><A><D><Q><R><K><K><A><Y><A><D><F><Y><R><N><Y><D><V><M><K><D><F><E><E><M><R><K><A><G><I><F><Q><S><V><K>
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from
P09669
Q8IYB4
PEX5R_HUMAN
Tetratricopeptide repeat-containing Rab8b-interacting protein
Homo
<M><Y><Q><G><H><M><Q><K><S><K><E><Q><G><Y><G><K><L><S><S><D><E><D><L><E><I><I><V><D><Q><K><Q><G><K><G><S><R><A><A><D><K><A><V><A><M><V><M><K><E><I><P><R><E><E><S><A><E><E><K><P><L><L><T><M><T><S><Q><L><V><N><E><Q><Q><E><S><R><P><L><L><S><P><S><I><D><D><F><L><C><E><T><K><S><E><A><I><A><R><P><V><T><S><N><T><A><V><L><T><T><G><L><D><L><L><D><L><S><E><P><V><S><Q><T><Q><T><K><A><K><K><S><E><P><S><S><K><T><S><S><L><K><K><K><A><D><G><S><D><L><I><S><T><D><A><E><Q><R><G><Q><P><L><R><V><P><E><T><S><S><L><D><L><D><I><Q><T><Q><L><E><K><W><D><D><V><K><F><H><G><D><R><N><T><K><G><H><P><M><A><E><R><K><S><S><S><S><R><T><G><S><K><E><L><L><W><S><S><E><H><R><S><Q><P><E><L><S><G><G><K><S><A><L><N><S><E><S><A><S><E><L><E><L><V><A><P><T><Q><A><R><L><T><K><E><H><R><W><G><S><A><L><L><S><R><N><H><S><L><E><E><E><F><E><R><A><K><A><A><V><E><S><D><T><E><F><W><D><K><M><Q><A><E><W><E><E><M><A><R><R><N><W><I><S><E><N><Q><E><A><Q><N><Q><V><T><I><S><A><S><E><K><G><Y><Y><F><H><T><E><N><P><F><K><D><W><P><G><A><F><E><E><G><L><K><R><L><K><E><G><D><L><P><V><T><I><L><F><M><E><A><A><I><L><Q><D><P><G><D><A><E><A><W><Q><F><L><G><I><T><Q><A><E><N><E><N><E><Q><A><A><I><V><A><L><Q><R><C><L><E><L><Q><P><N><N><L><K><A><L><M><A><L><A><V><S><Y><T><N><T><G><H><Q><Q><D><A><C><D><A><L><K><N><W><I><K><Q><N><P><K><Y><K><Y><L><V><K><S><K><K><G><S><P><G><L><T><R><R><M><S><K><S><P><V><D><S><S><V><L><E><G><V><K><E><L><Y><L><E><A><A><H><Q><N><G><D><M><I><D><P><D><L><Q><T><G><L><G><V><L><F><H><L><S><G><E><F><N><R><A><I><D><A><F><N><A><A><L><T><V><R><P><E><D><Y><S><L><W><N><R><L><G><A><T><L><A><N><G><D><R><S><E><E><A><V><E><A><Y><T><R><A><L><E><I><Q><P><G><F><I><R><S><R><Y><N><L><G><I><S><C><I><N><L><G><A><Y><R><E><A><V><S><N><F><L><T><A><L><S><L><Q><R><K><S><R><N><Q><Q><Q><V><P><H><P><A><I><S><G><N><I><W><A><A><L><R><I><A><L><S><L><M><D><Q><P><E><L><F><Q><A><A><N><L><G><D><L><D><V><L><L><R><A><F><N><L><D><P>
Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.<BOP>
Q8IYB4
Q9Y248
PSF2_HUMAN
GINS complex subunit 2
Homo
<M><D><A><A><E><V><E><F><L><A><E><K><E><L><V><T><I><I><P><N><F><S><L><D><K><I><Y><L><I><G><G><D><L><G><P><F><N><P><G><L><P><V><E><V><P><L><W><L><A><I><N><L><K><Q><R><Q><K><C><R><L><L><P><P><E><W><M><D><V><E><K><L><E><K><M><R><D><H><E><R><K><E><E><T><F><T><P><M><P><S><P><Y><Y><M><E><L><T><K><L><L><L><N><H><A><S><D><N><I><P><K><A><D><E><I><R><T><L><V><K><D><M><W><D><T><R><I><A><K><L><R><V><S><A><D><S><F><V><R><Q><Q><E><A><H><A><K><L><D><N><L><T><L><M><E><I><N><T><S><G><T><F><L><T><Q><A><L><N><H><M><Y><K><L><R><T><N><L><Q><P><L><E><S><T><Q><S><Q><D><F>
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks . GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built .<BOP>
Q9Y248
Q9Y5A7
NUB1_HUMAN
Renal carcinoma antigen NY-REN-18
Homo
<M><A><Q><K><K><Y><L><Q><A><K><L><T><Q><F><L><R><E><D><R><I><Q><L><W><K><P><P><Y><T><D><E><N><K><K><V><G><L><A><L><K><D><L><A><K><Q><Y><S><D><R><L><E><C><C><E><N><E><V><E><K><V><I><E><E><I><R><C><K><A><I><E><R><G><T><G><N><D><N><Y><R><T><T><G><I><A><T><I><E><V><F><L><P><P><R><L><K><K><D><R><K><N><L><L><E><T><R><L><H><I><T><G><R><E><L><R><S><K><I><A><E><T><F><G><L><Q><E><N><Y><I><K><I><V><I><N><K><K><Q><L><Q><L><G><K><T><L><E><E><Q><G><V><A><H><N><V><K><A><M><V><L><E><L><K><Q><S><E><E><D><A><R><K><N><F><Q><L><E><E><E><E><Q><N><E><A><K><L><K><E><K><Q><I><Q><R><T><K><R><G><L><E><I><L><A><K><R><A><A><E><T><V><V><D><P><E><M><T><P><Y><L><D><I><A><N><Q><T><G><R><S><I><R><I><P><P><S><E><R><K><A><L><M><L><A><M><G><Y><H><E><K><G><R><A><F><L><K><R><K><E><Y><G><I><A><L><P><C><L><L><D><A><D><K><Y><F><C><E><C><C><R><E><L><L><D><T><V><D><N><Y><A><V><L><Q><L><D><I><V><W><C><Y><F><R><L><E><Q><L><E><C><L><D><D><A><E><K><K><L><N><L><A><Q><K><C><F><K><N><C><Y><G><E><N><H><Q><R><L><V><H><I><K><G><N><C><G><K><E><K><V><L><F><L><R><L><Y><L><L><Q><G><I><R><N><Y><H><S><G><N><D><V><E><A><Y><E><Y><L><N><K><A><R><Q><L><F><K><E><L><Y><I><D><P><S><K><V><D><N><L><L><Q><L><G><F><T><A><Q><E><A><R><L><G><L><R><A><C><D><G><N><V><D><H><A><A><T><H><I><T><N><R><R><E><E><L><A><Q><I><R><K><E><E><K><E><K><K><R><R><R><L><E><N><I><R><F><L><K><G><M><G><Y><S><T><H><A><A><Q><Q><V><L><H><A><A><S><G><N><L><D><E><A><L><K><I><L><L><S><N><P><Q><M><W><W><L><N><D><S><N><P><E><T><D><N><R><Q><E><S><P><S><Q><E><N><I><D><R><L><V><Y><M><G><F><D><A><L><V><A><E><A><A><L><R><V><F><R><G><N><V><Q><L><A><A><Q><T><L><A><H><N><G><G><S><L><P><P><E><L><P><L><S><P><E><D><S><L><S><P><P><A><T><S><P><S><D><S><A><G><T><S><S><A><S><T><D><E><D><M><E><T><E><A><V><N><E><I><L><E><D><I><P><E><H><E><E><D><Y><L><D><S><T><L><E><D><E><E><I><I><I><A><E><Y><L><S><Y><V><E><N><R><K><S><A><T><K><K><N>
Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.<BOP>
Q9Y5A7
O76076
CCN5_HUMAN
WNT1-inducible-signaling pathway protein 2
Homo
<M><R><G><T><P><K><T><H><L><L><A><F><S><L><L><C><L><L><S><K><V><R><T><Q><L><C><P><T><P><C><T><C><P><W><P><P><P><R><C><P><L><G><V><P><L><V><L><D><G><C><G><C><C><R><V><C><A><R><R><L><G><E><P><C><D><Q><L><H><V><C><D><A><S><Q><G><L><V><C><Q><P><G><A><G><P><G><G><R><G><A><L><C><L><L><A><E><D><D><S><S><C><E><V><N><G><R><L><Y><R><E><G><E><T><F><Q><P><H><C><S><I><R><C><R><C><E><D><G><G><F><T><C><V><P><L><C><S><E><D><V><R><L><P><S><W><D><C><P><H><P><R><R><V><E><V><L><G><K><C><C><P><E><W><V><C><G><Q><G><G><G><L><G><T><Q><P><L><P><A><Q><G><P><Q><F><S><G><L><V><S><S><L><P><P><G><V><P><C><P><E><W><S><T><A><W><G><P><C><S><T><T><C><G><L><G><M><A><T><R><V><S><N><Q><N><R><F><C><R><L><E><T><Q><R><R><L><C><L><S><R><P><C><P><P><S><R><G><R><S><P><Q><N><S><A><F>
May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.<BOP>
O76076
Q9Y421
FA32A_HUMAN
Ovarian tumor-associated gene 12
Homo
<M><E><A><Y><E><Q><V><Q><K><G><P><L><K><L><K><G><V><A><E><L><G><V><T><K><R><K><K><K><K><K><D><K><D><K><A><K><L><L><E><A><M><G><T><S><K><K><N><E><E><E><K><R><R><G><L><D><K><R><T><P><A><Q><A><A><F><E><K><M><Q><E><K><R><Q><M><E><R><I><L><K><K><A><S><K><T><H><K><Q><R><V><E><D><F><N><R><H><L><D><T><L><T><E><H><Y><D><I><P><K><V><S><W><T><K>
Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.<BOP>
Q9Y421
P78415
IRX3_HUMAN
Iroquois homeobox protein 3
Homo
<M><S><F><P><Q><L><G><Y><Q><Y><I><R><P><L><Y><P><S><E><R><P><G><A><A><G><G><S><G><G><S><A><G><A><R><G><G><L><G><A><G><A><S><E><L><N><A><S><G><S><L><S><N><V><L><S><S><V><Y><G><A><P><Y><A><A><A><A><A><A><A><A><A><Q><G><Y><G><A><F><L><P><Y><A><A><E><L><P><I><F><P><Q><L><G><A><Q><Y><E><L><K><D><S><P><G><V><Q><H><P><A><A><A><A><A><F><P><H><P><H><P><A><F><Y><P><Y><G><Q><Y><Q><F><G><D><P><S><R><P><K><N><A><T><R><E><S><T><S><T><L><K><A><W><L><N><E><H><R><K><N><P><Y><P><T><K><G><E><K><I><M><L><A><I><I><T><K><M><T><L><T><Q><V><S><T><W><F><A><N><A><R><R><R><L><K><K><E><N><K><M><T><W><A><P><R><S><R><T><D><E><E><G><N><A><Y><G><S><E><R><E><E><E><D><E><E><E><D><E><E><D><G><K><R><E><L><E><L><E><E><E><E><L><G><G><E><E><E><D><T><G><G><E><G><L><A><D><D><D><E><D><E><E><I><D><L><E><N><L><D><G><A><A><T><E><P><E><L><S><L><A><G><A><A><R><R><D><G><D><L><G><L><G><P><I><S><D><S><K><N><S><D><S><E><D><S><S><E><G><L><E><D><R><P><L><P><V><L><S><L><A><P><A><P><P><P><V><A><V><A><S><P><S><L><P><S><P><P><V><S><L><D><P><C><A><P><A><P><A><P><A><S><A><L><Q><K><P><K><I><W><S><L><A><E><T><A><T><S><P><D><N><P><R><R><S><P><P><G><A><G><G><S><P><P><G><A><A><V><A><P><S><A><L><Q><L><S><P><A><A><A><A><A><A><A><H><R><L><V><S><A><P><L><G><K><F><P><A><W><T><N><R><P><F><P><G><P><P><P><G><P><R><L><H><P><L><S><L><L><G><S><A><P><P><H><L><L><G><L><P><G><A><A><G><H><P><A><A><A><A><A><F><A><R><P><A><E><P><E><G><G><T><D><R><C><S><A><L><E><V><E><K><K><L><L><K><T><A><F><Q><P><V><P><R><R><P><Q><N><H><L><D><A><A><L><V><L><S><A><L><S><S><S>
Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism.<BOP>
P78415
Q8IVG9
HUNIN_HUMAN
Humanin mitochondrial
Homo
<M><A><P><R><G><F><S><C><L><L><L><L><T><S><E><I><D><L><P><V><K><R><R><A>
Plays a role as a neuroprotective factor . Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease . Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR . Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2 . Inhibits amyloid-beta protein 40 fibril formation . Also inhibits amyloid-beta protein 42 fibril formation . Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria . Also suppresses apoptosis by binding to BID and inhibiting the interaction of BID with BAX and BAK which prevents oligomerization of BAX and BAK and suppresses release of apoptogenic proteins from mitochondria . Forms fibers with BAX and also with BID, inducing BAX and BID conformational changes and sequestering them into the fibers which prevents their activation . Can also suppress apoptosis by interacting with BIM isoform BimEL, inhibiting BimEL-induced activation of B
Q8IVG9
P24468
COT2_HUMAN
Nuclear receptor subfamily 2 group F member 2
Homo
<M><A><M><V><V><S><T><W><R><D><P><Q><D><E><V><P><G><S><Q><G><S><Q><A><S><Q><A><P><P><V><P><G><P><P><P><G><A><P><H><T><P><Q><T><P><G><Q><G><G><P><A><S><T><P><A><Q><T><A><A><G><G><Q><G><G><P><G><G><P><G><S><D><K><Q><Q><Q><Q><Q><H><I><E><C><V><V><C><G><D><K><S><S><G><K><H><Y><G><Q><F><T><C><E><G><C><K><S><F><F><K><R><S><V><R><R><N><L><S><Y><T><C><R><A><N><R><N><C><P><I><D><Q><H><H><R><N><Q><C><Q><Y><C><R><L><K><K><C><L><K><V><G><M><R><R><E><A><V><Q><R><G><R><M><P><P><T><Q><P><T><H><G><Q><F><A><L><T><N><G><D><P><L><N><C><H><S><Y><L><S><G><Y><I><S><L><L><L><R><A><E><P><Y><P><T><S><R><F><G><S><Q><C><M><Q><P><N><N><I><M><G><I><E><N><I><C><E><L><A><A><R><M><L><F><S><A><V><E><W><A><R><N><I><P><F><F><P><D><L><Q><I><T><D><Q><V><A><L><L><R><L><T><W><S><E><L><F><V><L><N><A><A><Q><C><S><M><P><L><H><V><A><P><L><L><A><A><A><G><L><H><A><S><P><M><S><A><D><R><V><V><A><F><M><D><H><I><R><I><F><Q><E><Q><V><E><K><L><K><A><L><H><V><D><S><A><E><Y><S><C><L><K><A><I><V><L><F><T><S><D><A><C><G><L><S><D><V><A><H><V><E><S><L><Q><E><K><S><Q><C><A><L><E><E><Y><V><R><S><Q><Y><P><N><Q><P><T><R><F><G><K><L><L><L><R><L><P><S><L><R><T><V><S><S><S><V><I><E><Q><L><F><F><V><R><L><V><G><K><T><P><I><E><T><L><I><R><D><M><L><L><S><G><S><S><F><N><W><P><Y><M><A><I><Q>
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development .<BOP>
P24468
Q6ZVM7
TM1L2_HUMAN
Target of Myb-like protein 2
Homo
<M><E><F><L><L><G><N><P><F><S><T><P><V><G><Q><C><L><E><K><A><T><D><G><S><L><Q><S><E><D><W><T><L><N><M><E><I><C><D><I><I><N><E><T><E><E><G><P><K><D><A><I><R><A><L><K><K><R><L><N><G><N><R><N><Y><R><E><V><M><L><A><L><T><V><L><E><T><C><V><K><N><C><G><H><R><F><H><I><L><V><A><N><R><D><F><I><D><S><V><L><V><K><I><I><S><P><K><N><N><P><P><T><I><V><Q><D><K><V><L><A><L><I><Q><A><W><A><D><A><F><R><S><S><P><D><L><T><G><V><V><H><I><Y><E><E><L><K><R><K><G><V><E><F><P><M><A><D><L><D><A><L><S><P><I><H><T><P><Q><R><S><V><P><E><V><D><P><A><A><T><M><P><R><S><Q><S><Q><Q><R><T><S><A><G><S><Y><S><S><P><P><P><A><P><Y><S><A><P><Q><A><P><A><L><S><V><T><G><P><I><T><A><N><S><E><Q><I><A><R><L><R><S><E><L><D><V><V><R><G><N><T><K><V><M><S><E><M><L><T><E><M><V><P><G><Q><E><D><S><S><D><L><E><L><L><Q><E><L><N><R><T><C><R><A><M><Q><Q><R><I><V><E><L><I><S><R><V><S><N><E><E><V><T><E><E><L><L><H><V><N><D><D><L><N><N><V><F><L><R><Y><E><R><F><E><R><Y><R><S><G><R><S><V><Q><N><A><S><N><G><V><L><N><E><V><T><E><D><N><L><I><D><L><G><P><G><S><P><A><V><V><S><P><M><V><G><N><T><A><P><P><S><S><L><S><S><Q><L><A><G><L><D><L><G><T><E><S><V><S><G><T><L><S><S><L><Q><Q><C><N><P><R><D><G><F><D><M><F><A><Q><T><R><G><N><S><L><A><E><Q><R><K><T><V><T><Y><E><D><P><Q><A><V><G><G><L><A><S><A><L><D><N><R><K><Q><S><S><E><G><I><P><V><A><Q><P><S><V><M><D><D><I><E><V><W><L><R><T><D><L><K><G><D><D><L><E><E><G><V><T><S><E><E><F><D><K><F><L><E><E><R><A><K><A><A><E><M><V><P><D><L><P><S><P><P><M><E><A><P><A><P><A><S><N><P><S><G><R><K><K><P><E><R><S><E><D><A><L><F><A><L>
Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures . May also play a role in recruiting clathrin to endosomes . May regulate growth factor-induced mitogenic signaling .<BOP>
Q6ZVM7
O43309
ZSC12_HUMAN
Zinc finger protein 96
Homo
<M><A><S><T><W><A><I><Q><A><H><M><D><Q><D><E><P><L><E><V><K><I><E><E><E><K><Y><T><T><R><Q><D><W><D><L><R><K><N><N><T><H><S><R><E><V><F><R><Q><Y><F><R><Q><F><C><Y><Q><E><T><S><G><P><R><E><A><L><S><R><L><R><E><L><C><H><Q><W><L><R><P><E><T><H><T><K><E><Q><I><L><E><L><L><V><L><E><Q><F><L><T><I><L><P><E><E><L><Q><A><W><V><Q><E><Q><H><P><E><S><G><E><E><V><V><T><V><L><E><D><L><E><R><E><L><D><E><P><G><E><Q><V><S><V><H><T><G><E><Q><E><M><F><L><Q><E><T><V><R><L><R><K><E><G><E><P><S><M><S><L><Q><S><M><K><A><Q><P><K><Y><E><S><P><E><L><E><S><Q><Q><E><Q><V><L><D><V><E><T><G><N><E><Y><G><N><L><K><Q><E><V><S><E><E><M><E><P><H><G><K><T><S><S><K><F><E><N><D><M><S><K><S><A><R><C><G><E><T><R><E><P><E><E><I><T><E><E><P><S><A><C><S><R><E><D><K><Q><P><T><C><D><E><N><G><V><S><L><T><E><N><S><D><H><T><E><H><Q><R><I><C><P><G><E><E><S><Y><G><C><D><D><C><G><K><A><F><S><Q><H><S><H><L><I><E><H><Q><R><I><H><T><G><D><R><P><Y><K><C><E><E><C><G><K><A><F><R><G><R><T><V><L><I><R><H><K><I><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><G><R><W><S><A><L><N><Q><H><Q><R><L><H><T><G><E><K><H><Y><H><C><N><D><C><G><K><A><F><S><Q><K><A><G><L><F><H><H><I><K><I><H><T><R><D><K><P><Y><Q><C><T><Q><C><N><K><S><F><S><R><R><S><I><L><T><Q><H><Q><G><V><H><T><G><A><K><P><Y><E><C><N><E><C><G><K><A><F><V><Y><N><S><S><L><V><S><H><Q><E><I><H><H><K><E><K><C><Y><Q><C><K><E><C><G><K><S><F><S><Q><S><G><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><D><V><C><E><K><A><F><I><Q><R><T><S><L><T><E><H><Q><R><I><H><T><G><E><R><P><Y><K><C><D><K><C><G><K><A><F><T><Q><R><S><V><L><T><E><H><Q><R><I><H><T><G><E><R><P><Y><K><C><D><E><C><G><N><A><F><R><G><I><T><S><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><Q><C><D><E><C><G><K><A><F><R><Q><R><S><D><L><S><K><H><Q><R><I><H><N><R><R><G><T><Y><V><C><K><E><C><G><K><S><F><R><Q><N><S><A><L><T><Q><H><Q><T><I><H><K><G><E><K><S><V><S><V>
May be involved in transcriptional regulation.<BOP>
O43309
Q5T6S3
PHF19_HUMAN
Polycomb-like protein 3
Homo
<M><E><N><R><A><L><D><P><G><T><R><D><S><Y><G><A><T><S><H><L><P><N><K><G><A><L><A><K><V><K><N><N><F><K><D><L><M><S><K><L><T><E><G><Q><Y><V><L><C><R><W><T><D><G><L><Y><Y><L><G><K><I><K><R><V><S><S><S><K><Q><S><C><L><V><T><F><E><D><N><S><K><Y><W><V><L><W><K><D><I><Q><H><A><G><V><P><G><E><E><P><K><C><N><I><C><L><G><K><T><S><G><P><L><N><E><I><L><I><C><G><K><C><G><L><G><Y><H><Q><Q><C><H><I><P><I><A><G><S><A><D><Q><P><L><L><T><P><W><F><C><R><R><C><I><F><A><L><A><V><R><K><G><G><A><L><K><K><G><A><I><A><R><T><L><Q><A><V><K><M><V><L><S><Y><Q><P><E><E><L><E><W><D><S><P><H><R><T><N><Q><Q><Q><C><Y><C><Y><C><G><G><P><G><E><W><Y><L><R><M><L><Q><C><Y><R><C><R><Q><W><F><H><E><A><C><T><Q><C><L><N><E><P><M><M><F><G><D><R><F><Y><L><F><F><C><S><V><C><N><Q><G><P><E><Y><I><E><R><L><P><L><R><W><V><D><V><V><H><L><A><L><Y><N><L><G><V><Q><S><K><K><K><Y><F><D><F><E><E><I><L><A><F><V><N><H><H><W><E><L><L><Q><L><G><K><L><T><S><T><P><V><T><D><R><G><P><H><L><L><N><A><L><N><S><Y><K><S><R><F><L><C><G><K><E><I><K><K><K><K><C><I><F><R><L><R><I><R><V><P><P><N><P><P><G><K><L><L><P><D><K><G><L><L><P><N><E><N><S><A><S><S><E><L><R><K><R><G><K><S><K><P><G><L><L><P><H><E><F><Q><Q><Q><K><R><R><V><Y><R><R><K><R><S><K><F><L><L><E><D><A><I><P><S><S><D><F><T><S><A><W><S><T><N><H><H><L><A><S><I><F><D><F><T><L><D><E><I><Q><S><L><K><S><A><S><S><G><Q><T><F><F><S><D><V><D><S><T><D><A><A><S><T><S><G><S><A><S><T><S><L><S><Y><D><S><R><W><T><V><G><S><R><K><R><K><L><A><A><K><A><Y><M><P><L><R><A><K><R><W><A><A><E><L><D><G><R><C><P><S><D><S><S><A><E><G><A><S><V><P><E><R><P><D><E><G><I><D><S><H><T><F><E><S><I><S><E><D><D><S><S><L><S><H><L><K><S><S><I><T><N><Y><F><G><A><A><G><R><L><A><C><G><E><K><Y><Q><V><L><A><R><R><V><T><P><E><G><K><V><Q><Y><L><V><E><W><E><G><T><T><P><Y>
Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity . Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing . Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) . Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter .<BOP>
Q5T6S3
P63121
VP113_HUMAN
Proteinase
Homo
<W><A><S><Q><V><S><E><N><R><P><V><C><K><A><I><I><Q><G><K><Q><F><E><G><L><V><D><T><G><A><D><V><S><I><I><A><L><N><Q><W><P><K><N><W><P><K><Q><K><A><V><T><G><L><V><G><I><S><T><A><S><E><V><Y><Q><S><T><E><I><L><H><C><L><G><P><D><N><Q><E><S><T><V><Q><P><M><I><T><S><I><P><L><N><L><W><G><R><D><L><L><Q><Q><W><G><V><E><I><T><M><P><A><P><L><Y><S><P><T><S><Q><K><I><M><T><K><M><G><Y><I><P><G><K><G><L><G><K><N><E><D><G><I><K><V><P><V><E><A><K><I><N><Q><E><R><E><G><I><G><Y><P><F>
Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.<BOP>
P63121
P09630
HXC6_HUMAN
Homeobox protein Hox-3C
Homo
<M><N><S><Y><F><T><N><P><S><L><S><C><H><L><A><G><G><Q><D><V><L><P><N><V><A><L><N><S><T><A><Y><D><P><V><R><H><F><S><T><Y><G><A><A><V><A><Q><N><R><I><Y><S><T><P><F><Y><S><P><Q><E><N><V><V><F><S><S><S><R><G><P><Y><D><Y><G><S><N><S><F><Y><Q><E><K><D><M><L><S><N><C><R><Q><N><T><L><G><H><N><T><Q><T><S><I><A><Q><D><F><S><S><E><Q><G><R><T><A><P><Q><D><Q><K><A><S><I><Q><I><Y><P><W><M><Q><R><M><N><S><H><S><G><V><G><Y><G><A><D><R><R><R><G><R><Q><I><Y><S><R><Y><Q><T><L><E><L><E><K><E><F><H><F><N><R><Y><L><T><R><R><R><R><I><E><I><A><N><A><L><C><L><T><E><R><Q><I><K><I><W><F><Q><N><R><R><M><K><W><K><K><E><S><N><L><T><S><T><L><S><G><G><G><G><G><A><T><A><D><S><L><G><G><K><E><E><K><R><E><E><T><E><E><E><K><Q><K><E>
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP>
P09630
Q9Y282
ERGI3_HUMAN
Serologically defined breast cancer antigen NY-BR-84
Homo
<M><E><A><L><G><K><L><K><Q><F><D><A><Y><P><K><T><L><E><D><F><R><V><K><T><C><G><G><A><T><V><T><I><V><S><G><L><L><M><L><L><L><F><L><S><E><L><Q><Y><Y><L><T><T><E><V><H><P><E><L><Y><V><D><K><S><R><G><D><K><L><K><I><N><I><D><V><L><F><P><H><M><P><C><A><Y><L><S><I><D><A><M><D><V><A><G><E><Q><Q><L><D><V><E><H><N><L><F><K><Q><R><L><D><K><D><G><I><P><V><S><S><E><A><E><R><H><E><L><G><K><V><E><V><T><V><F><D><P><D><S><L><D><P><D><R><C><E><S><C><Y><G><A><E><A><E><D><I><K><C><C><N><T><C><E><D><V><R><E><A><Y><R><R><R><G><W><A><F><K><N><P><D><T><I><E><Q><C><R><R><E><G><F><S><Q><K><M><Q><E><Q><K><N><E><G><C><Q><V><Y><G><F><L><E><V><N><K><V><A><G><N><F><H><F><A><P><G><K><S><F><Q><Q><S><H><V><H><V><H><D><L><Q><S><F><G><L><D><N><I><N><M><T><H><Y><I><Q><H><L><S><F><G><E><D><Y><P><G><I><V><N><P><L><D><H><T><N><V><T><A><P><Q><A><S><M><M><F><Q><Y><F><V><K><V><V><P><T><V><Y><M><K><V><D><G><E><V><L><R><T><N><Q><F><S><V><T><R><H><E><K><V><A><N><G><L><L><G><D><Q><G><L><P><G><V><F><V><L><Y><E><L><S><P><M><M><V><K><L><T><E><K><H><R><S><F><T><H><F><L><T><G><V><C><A><I><I><G><G><M><F><T><V><A><G><L><I><D><S><L><I><Y><H><S><A><R><A><I><Q><K><K><I><D><L><G><K><T><T>
Possible role in transport between endoplasmic reticulum and Golgi. Positively regulates trafficking of the secretory proteins SERPINA1/alpha1-antitrypsin and HP/haptoglobin .<BOP>
Q9Y282
Q12912
IRAG2_HUMAN
Processed inositol 1,4,5-triphosphate receptor associated 2
Homo
<M><E><S><T><P><F><S><G><V><A><N><Q><I><H><T><L><C><E><R><P><T><Y><G><E><V><K><D><G><A><L><D><V><K><R><Q><H><K><C><P><G><P><T><S><G><P><S><P><G><T><N><L><S><G><C><I><R><M><N><D><D><P><S><M><E><E><N><G><V><E><R><V><C><P><E><S><L><L><Q><S><R><E><Y><S><S><L><P><L><P><R><H><T><S><S><T><D><G><T><I><T><S><S><D><P><G><L><E><I><L><N><M><A><S><C><D><L><D><R><N><S><L><C><K><K><E><E><D><T><R><S><A><S><P><T><I><E><A><Q><G><T><S><P><A><H><D><N><I><A><F><Q><D><S><T><S><K><D><K><T><I><L><N><L><E><A><K><E><E><P><E><T><I><E><E><H><K><K><E><H><A><S><G><D><S><V><V><S><P><L><P><V><T><T><V><K><S><V><N><L><R><Q><S><E><N><T><S><A><N><E><K><E><V><E><A><E><F><L><R><L><S><L><G><F><K><C><D><W><F><T><L><E><K><R><V><K><L><E><E><R><S><R><D><L><A><E><E><N><L><K><K><E><I><T><N><C><L><K><L><L><E><S><L><T><P><L><C><E><D><D><N><Q><A><Q><E><I><I><K><K><L><E><K><S><I><K><F><L><S><Q><C><A><A><R><V><A><S><R><A><E><M><L><G><A><I><N><Q><E><S><R><V><S><K><A><V><E><V><M><I><Q><H><V><E><N><L><K><R><M><Y><A><K><E><H><A><E><L><E><E><L><K><Q><V><L><L><Q><N><E><R><S><F><N><P><L><E><D><D><D><D><C><Q><I><K><K><R><S><A><S><L><N><S><K><P><S><S><L><R><R><V><T><I><A><S><L><P><R><N><I><G><N><A><G><M><V><A><G><M><E><N><N><D><R><F><S><R><R><S><S><S><W><R><I><L><G><S><K><Q><S><E><H><R><P><S><L><P><R><F><I><S><T><Y><S><W><A><D><A><E><E><E><K><C><E><L><K><T><K><D><D><S><E><P><S><G><E><E><T><V><E><R><T><R><K><P><S><L><S><E><K><K><N><N><P><S><K><W><D><V><S><S><V><Y><D><T><I><A><S><W><A><T><N><L><K><S><S><I><R><K><A><N><K><A><L><W><L><S><I><A><F><I><V><L><F><A><A><L><M><S><F><L><T><G><Q><L><F><Q><K><S><V><D><A><A><P><T><Q><Q><E><D><S><W><T><S><L><E><H><I><L><W><P><F><T><R><L><R><H><N><G><P><P><P><V>
Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules.<BOP>
Q12912
Q15067
ACOX1_HUMAN
Peroxisomal acyl-CoA oxidase 1, C chain
Homo
<M><N><P><D><L><R><R><E><R><D><S><A><S><F><N><P><E><L><L><T><H><I><L><D><G><S><P><E><K><T><R><R><R><R><E><I><E><N><M><I><L><N><D><P><D><F><Q><H><E><D><L><N><F><L><T><R><S><Q><R><Y><E><V><A><V><R><K><S><A><I><M><V><K><K><M><R><E><F><G><I><A><D><P><D><E><I><M><W><F><K><K><L><H><L><V><N><F><V><E><P><V><G><L><N><Y><S><M><F><I><P><T><L><L><N><Q><G><T><T><A><Q><K><E><K><W><L><L><S><S><K><G><L><Q><I><I><G><T><Y><A><Q><T><E><M><G><H><G><T><H><L><R><G><L><E><T><T><A><T><Y><D><P><E><T><Q><E><F><I><L><N><S><P><T><V><T><S><I><K><W><W><P><G><G><L><G><K><T><S><N><H><A><I><V><L><A><Q><L><I><T><K><G><K><C><Y><G><L><H><A><F><I><V><P><I><R><E><I><G><T><H><K><P><L><P><G><I><T><V><G><D><I><G><P><K><F><G><Y><D><E><I><D><N><G><Y><L><K><M><D><N><H><R><I><P><R><E><N><M><L><M><K><Y><A><Q><V><K><P><D><G><T><Y><V><K><P><L><S><N><K><L><T><Y><G><T><M><V><F><V><R><S><F><L><V><G><E><A><A><R><A><L><S><K><A><C><T><I><A><I><R><Y><S><A><V><R><H><Q><S><E><I><K><P><G><E><P><E><P><Q><I><L><D><F><Q><T><Q><Q><Y><K><L><F><P><L><L><A><T><A><Y><A><F><Q><F><V><G><A><Y><M><K><E><T><Y><H><R><I><N><E><G><I><G><Q><G><D><L><S><E><L><P><E><L><H><A><L><T><A><G><L><K><A><F><T><S><W><T><A><N><T><G><I><E><A><C><R><M><A><C><G><G><H><G><Y><S><H><C><S><G><L><P><N><I><Y><V><N><F><T><P><S><C><T><F><E><G><E><N><T><V><M><M><L><Q><T><A><R><F><L><M><K><S><Y><D><Q><V><H><S><G><K><L><V><C><G><M><V><S><Y><L><N><D><L><P><S><Q><R><I><Q><P><Q><Q><V><A><V><W><P><T><M><V><D><I><N><S><P><E><S><L><T><E><A><Y><K><L><R><A><A><R><L><V><E><I><A><A><K><N><L><Q><K><E><V><I><H><R><K><S><K><E><V><A><W><N><L><T><S><V><D><L><V><R><A><S><E><A><H><C><H><Y><V><V><V><K><L><F><S><E><K><L><L><K><I><Q><D><K><A><I><Q><A><V><L><R><S><L><C><L><L><Y><S><L><Y><G><I><S><Q><N><A><G><D><F><L><Q><G><S><I><M><T><E><P><Q><I><T><Q><V><N><Q><R><V><K><E><L><L><T><L><I><R><S><D><A><V><A><L><V><D><A><F><D><F><Q><D><V><T><L><G><S><V><L><G><R><Y><D><G><N><V><Y><E><N><L><F><E><W><A><K><N><S><P><L><N><K><A><E><V><H><E><S><Y><K><H><L><K><S><L><Q><S><K><L>
Is active against a much broader range of substrates and shows activity towards long-chain fatty acyl-CoAs.<BOP>
Q15067
Q9UBK5
HCST_HUMAN
Transmembrane adapter protein KAP10
Homo
<M><I><H><L><G><H><I><L><F><L><L><L><L><P><V><A><A><A><Q><T><T><P><G><E><R><S><S><L><P><A><F><Y><P><G><T><S><G><S><C><S><G><C><G><S><L><S><L><P><L><L><A><G><L><V><A><A><D><A><V><A><S><L><L><I><V><G><A><V><F><L><C><A><R><P><R><R><S><P><A><Q><E><D><G><K><V><Y><I><N><M><P><G><R><G>
Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance
Q9UBK5
Q9Y463
DYR1B_HUMAN
Mirk protein kinase
Homo
<M><A><V><P><P><G><H><G><P><F><S><G><F><P><G><P><Q><E><H><T><Q><V><L><P><D><V><R><L><L><P><R><R><L><P><L><A><F><R><D><A><T><S><A><P><L><R><K><L><S><V><D><L><I><K><T><Y><K><H><I><N><E><V><Y><Y><A><K><K><K><R><R><A><Q><Q><A><P><P><Q><D><S><S><N><K><K><E><K><K><V><L><N><H><G><Y><D><D><D><N><H><D><Y><I><V><R><S><G><E><R><W><L><E><R><Y><E><I><D><S><L><I><G><K><G><S><F><G><Q><V><V><K><A><Y><D><H><Q><T><Q><E><L><V><A><I><K><I><I><K><N><K><K><A><F><L><N><Q><A><Q><I><E><L><R><L><L><E><L><M><N><Q><H><D><T><E><M><K><Y><Y><I><V><H><L><K><R><H><F><M><F><R><N><H><L><C><L><V><F><E><L><L><S><Y><N><L><Y><D><L><L><R><N><T><H><F><R><G><V><S><L><N><L><T><R><K><L><A><Q><Q><L><C><T><A><L><L><F><L><A><T><P><E><L><S><I><I><H><C><D><L><K><P><E><N><I><L><L><C><N><P><K><R><S><A><I><K><I><V><D><F><G><S><S><C><Q><L><G><Q><R><I><Y><Q><Y><I><Q><S><R><F><Y><R><S><P><E><V><L><L><G><T><P><Y><D><L><A><I><D><M><W><S><L><G><C><I><L><V><E><M><H><T><G><E><P><L><F><S><G><S><N><E><V><D><Q><M><N><R><I><V><E><V><L><G><I><P><P><A><A><M><L><D><Q><A><P><K><A><R><K><Y><F><E><R><L><P><G><G><G><W><T><L><R><R><T><K><E><L><R><K><D><Y><Q><G><P><G><T><R><R><L><Q><E><V><L><G><V><Q><T><G><G><P><G><G><R><R><A><G><E><P><G><H><S><P><A><D><Y><L><R><F><Q><D><L><V><L><R><M><L><E><Y><E><P><A><A><R><I><S><P><L><G><A><L><Q><H><G><F><F><R><R><T><A><D><E><A><T><N><T><G><P><A><G><S><S><A><S><T><S><P><A><P><L><D><T><C><P><S><S><S><T><A><S><S><I><S><S><S><G><G><S><S><G><S><S><S><D><N><R><T><Y><R><Y><S><N><R><Y><C><G><G><P><G><P><P><I><T><D><C><E><M><N><S><P><Q><V><P><P><S><Q><P><L><R><P><W><A><G><G><D><V><P><H><K><T><H><Q><A><P><A><S><A><S><S><L><P><G><T><G><A><Q><L><P><P><Q><P><R><Y><L><G><R><P><P><S><P><T><S><P><P><P><P><E><L><M><D><V><S><L><V><G><G><P><A><D><C><S><P><P><H><P><A><P><A><P><Q><H><P><A><A><S><A><L><R><T><R><M><T><G><G><R><P><P><L><P><P><P><D><D><P><A><T><L><G><P><H><L><G><L><R><G><V><P><Q><S><T><A><A><S><S>
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance . During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2 . Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1).<BOP>
Q9Y463
Q4G0A6
MINY4_HUMAN
Probable deubiquitinating enzyme MINDY-4
Homo
<M><D><S><L><F><V><E><E><V><A><A><S><L><V><R><E><F><L><S><R><K><G><L><K><K><T><C><V><T><M><D><Q><E><R><P><R><S><D><L><S><I><N><N><R><N><D><L><R><K><V><L><H><L><E><F><L><Y><K><E><N><K><A><K><E><N><P><L><K><T><S><L><E><L><I><T><R><Y><F><L><D><H><F><G><N><T><A><N><N><F><T><Q><D><T><P><I><P><A><L><S><V><P><K><K><N><N><K><V><P><S><R><C><S><E><T><T><L><V><N><I><Y><D><L><S><D><E><D><A><G><W><R><T><S><L><S><E><T><S><K><A><R><H><D><N><L><D><G><D><V><L><G><N><F><V><S><S><K><R><P><P><H><K><S><K><P><M><Q><T><V><P><G><E><T><P><V><L><T><S><A><W><E><K><I><D><K><L><H><S><E><P><S><L><D><V><K><R><M><G><E><N><S><R><P><K><S><G><L><I><V><R><G><M><M><S><G><P><I><A><S><S><P><Q><D><S><F><H><R><H><Y><L><R><R><S><S><P><S><S><S><S><T><Q><P><Q><E><E><S><R><K><V><P><E><L><F><V><C><T><Q><Q><D><I><L><A><S><S><N><S><S><P><S><R><T><S><L><G><Q><L><S><E><L><T><V><E><R><Q><K><T><T><A><S><S><P><P><H><L><P><S><K><R><L><P><P><W><D><R><A><R><P><R><D><P><S><E><D><T><P><A><V><D><G><S><T><D><T><D><R><M><P><L><K><L><Y><L><P><G><G><N><S><R><M><T><Q><E><R><L><E><R><A><F><K><R><Q><G><S><Q><P><A><P><V><R><K><N><Q><L><L><P><S><D><K><V><D><G><E><L><G><A><L><R><L><E><D><V><E><D><E><L><I><R><E><E><V><I><L><S><P><V><P><S><V><L><K><L><Q><T><A><S><K><P><I><D><L><S><V><A><K><E><I><K><T><L><L><F><G><S><S><F><C><C><F><N><E><E><W><K><L><Q><S><F><S><F><S><N><T><A><S><L><K><Y><G><I><V><Q><N><K><G><G><P><C><G><V><L><A><A><V><Q><G><C><V><L><Q><K><L><L><F><E><G><D><S><K><A><D><C><A><Q><G><L><Q><P><S><D><A><H><R><T><R><C><L><V><L><A><L><A><D><I><V><W><R><A><G><G><R><E><R><A><V><V><A><L><A><S><R><T><Q><Q><F><S><P><T><G><K><Y><K><A><D><G><V><L><E><T><L><T><L><H><S><L><T><C><Y><E><D><L><V><T><F><L><Q><Q><S><I><H><Q><F><E><V><G><P><Y><G><C><I><L><L><T><L><S><A><I><L><S><R><S><T><E><L><I><R><Q><D><F><D><V><P><T><S><H><L><I><G><A><H><G><Y><C><T><Q><E><L><V><N><L><L><L><T><G><K><A><V><S><N><V><F><N><D><V><V><E><L><D><S><G><D><G><N><I><T><L><L><R><G><I><A><A><R><S><D><I><G><F><L><S><L><F><E><H><Y><N><M><C><Q><V><G><C><F><L><K><T><P><R><F><P><I><W><V><V><C><S><E><S><H><F><S><I><L><F><S><L><Q><P><G><L><L><R><D><W><R><T><E><R><L><F><D><L><Y><Y><Y><D><G><L><A><N><Q><Q><E><Q><I><R><L><T><I><D><T><T><Q><T><I><S><E><D><T><D><N><D><L><V><P><P><L><E><L><C><I><R><T><K><W><K><G><A><S><V><N><W><N><G><S><D><P><I><L>
Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.<BOP>
Q4G0A6
O75414
NDK6_HUMAN
nm23-H6
Homo
<M><A><S><I><L><R><S><P><Q><A><L><Q><L><T><L><A><L><I><K><P><D><A><V><A><H><P><L><I><L><E><A><V><H><Q><Q><I><L><S><N><K><F><L><I><V><R><M><R><E><L><L><W><R><K><E><D><C><Q><R><F><Y><R><E><H><E><G><R><F><F><Y><Q><R><L><V><E><F><M><A><S><G><P><I><R><A><Y><I><L><A><H><K><D><A><I><Q><L><W><R><T><L><M><G><P><T><R><V><F><R><A><R><H><V><A><P><D><S><I><R><G><S><F><G><L><T><D><T><R><N><T><T><H><G><S><D><S><V><V><S><A><S><R><E><I><A><A><F><F><P><D><F><S><E><Q><R><W><Y><E><E><E><E><P><Q><L><R><C><G><P><V><C><Y><S><P><E><G><G><V><H><Y><V><A><G><T><G><G><L><G><P><A>
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.<BOP>
O75414
Q8NH09
OR8S1_HUMAN
Olfactory receptor 8S1
Homo
<M><A><L><G><N><H><S><T><I><T><E><F><L><L><L><G><L><S><A><D><P><N><I><R><A><L><L><F><V><L><F><L><G><I><Y><L><L><T><I><M><E><N><L><M><L><L><L><M><I><R><A><D><S><C><L><H><K><P><M><Y><F><F><L><S><H><L><S><F><V><D><L><C><F><S><S><V><I><V><P><K><M><L><E><N><L><L><S><Q><R><K><T><I><S><V><E><G><C><L><A><Q><V><F><F><V><F><V><T><A><G><T><E><A><C><L><L><S><G><M><A><Y><D><R><H><A><A><I><C><R><P><L><L><Y><G><Q><I><M><G><K><Q><L><Y><M><H><L><V><W><G><S><W><G><L><G><F><L><D><A><L><I><N><V><L><L><A><V><N><M><V><F><C><E><A><K><I><I><H><H><Y><S><Y><E><M><P><S><L><L><P><L><S><C><S><D><I><S><R><S><L><I><A><L><L><C><S><T><L><L><H><G><L><G><N><F><L><L><V><F><L><S><Y><T><R><I><I><S><T><I><L><S><I><S><S><T><S><G><R><S><K><A><F><S><T><C><S><A><H><L><T><A><V><T><L><Y><Y><G><S><G><L><L><R><H><L><M><P><N><S><G><S><P><I><E><L><I><F><S><V><Q><Y><T><V><V><T><P><M><L><N><S><L><I><Y><S><L><K><N><K><E><V><K><G><E><R><S><L><R><D><S><S><H><L><P><Q><L><H><K><G><Q><A><R><W><K><R><P><A><F><T><E><G><R><R><E><P><G><H><P><E><L><S><I><P><V><T><P><Q><P><Q><G><A><C><A><C><S><A><L><R><A><A><P><T><A><L><P>
Odorant receptor.<BOP>
Q8NH09
Q96S37
S22AC_HUMAN
Urate:anion antiporter SLC22A12
Homo
<M><A><F><S><E><L><L><D><L><V><G><G><L><G><R><F><Q><V><L><Q><T><M><A><L><M><V><S><I><M><W><L><C><T><Q><S><M><L><E><N><F><S><A><A><V><P><S><H><R><C><W><A><P><L><L><D><N><S><T><A><Q><A><S><I><L><G><S><L><S><P><E><A><L><L><A><I><S><I><P><P><G><P><N><Q><R><P><H><Q><C><R><R><F><R><Q><P><Q><W><Q><L><L><D><P><N><A><T><A><T><S><W><S><E><A><D><T><E><P><C><V><D><G><W><V><Y><D><R><S><I><F><T><S><T><I><V><A><K><W><N><L><V><C><D><S><H><A><L><K><P><M><A><Q><S><I><Y><L><A><G><I><L><V><G><A><A><A><C><G><P><A><S><D><R><F><G><R><R><L><V><L><T><W><S><Y><L><Q><M><A><V><M><G><T><A><A><A><F><A><P><A><F><P><V><Y><C><L><F><R><F><L><L><A><F><A><V><A><G><V><M><M><N><T><G><T><L><L><M><E><W><T><A><A><R><A><R><P><L><V><M><T><L><N><S><L><G><F><S><F><G><H><G><L><T><A><A><V><A><Y><G><V><R><D><W><T><L><L><Q><L><V><V><S><V><P><F><F><L><C><F><L><Y><S><W><W><L><A><E><S><A><R><W><L><L><T><T><G><R><L><D><W><G><L><Q><E><L><W><R><V><A><A><I><N><G><K><G><A><V><Q><D><T><L><T><P><E><V><L><L><S><A><M><R><E><E><L><S><M><G><Q><P><P><A><S><L><G><T><L><L><R><M><P><G><L><R><F><R><T><C><I><S><T><L><C><W><F><A><F><G><F><T><F><F><G><L><A><L><D><L><Q><A><L><G><S><N><I><F><L><L><Q><M><F><I><G><V><V><D><I><P><A><K><M><G><A><L><L><L><L><S><H><L><G><R><R><P><T><L><A><A><S><L><L><L><A><G><L><C><I><L><A><N><T><L><V><P><H><E><M><G><A><L><R><S><A><L><A><V><L><G><L><G><G><V><G><A><A><F><T><C><I><T><I><Y><S><S><E><L><F><P><T><V><L><R><M><T><A><V><G><L><G><Q><M><A><A><R><G><G><A><I><L><G><P><L><V><R><L><L><G><V><H><G><P><W><L><P><L><L><V><Y><G><T><V><P><V><L><S><G><L><A><A><L><L><L><P><E><T><Q><S><L><P><L><P><D><T><I><Q><D><V><Q><N><Q><A><V><K><K><A><T><H><G><T><L><G><N><S><V><L><K><S><T><Q><F>
Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions . Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid . Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) . Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate . Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption . Orotate transport is Cl(-)-dependent .<BOP>
Q96S37
Q9Y330
ZBT12_HUMAN
Protein G10
Homo
<M><A><S><G><V><E><V><L><R><F><Q><L><P><G><H><E><A><A><T><L><R><N><M><N><Q><L><R><A><E><E><R><F><C><D><V><T><I><V><A><D><S><L><K><F><R><G><H><K><V><I><L><A><A><C><S><P><F><L><R><D><Q><F><L><L><N><P><S><S><E><L><Q><V><S><L><M><H><S><A><R><I><V><A><D><L><L><L><S><C><Y><T><G><A><L><E><F><A><V><R><D><I><V><N><Y><L><T><A><A><S><Y><L><Q><M><E><H><V><V><E><K><C><R><N><A><L><S><Q><F><I><E><P><K><I><G><L><K><E><D><G><V><S><E><A><S><L><V><S><S><I><S><A><T><K><S><L><L><P><P><A><R><T><P><K><P><A><P><K><P><P><P><P><P><P><L><P><P><P><L><L><R><P><V><K><L><E><F><P><L><D><E><D><L><E><L><K><A><E><E><E><D><E><D><E><D><E><D><V><S><D><I><C><I><V><K><V><E><S><A><L><E><V><A><H><R><L><K><P><P><G><G><L><G><G><G><L><G><I><G><G><S><V><G><G><H><L><G><E><L><A><Q><S><S><V><P><P><S><T><V><A><P><P><Q><G><V><V><K><A><C><Y><S><L><S><E><D><A><E><G><E><G><L><L><L><I><P><G><G><R><A><S><V><G><A><T><S><G><L><V><E><A><A><A><V><A><M><A><A><R><G><A><G><G><S><L><G><A><G><G><S><R><G><P><L><P><G><G><F><S><G><G><N><P><L><K><N><I><K><C><T><K><C><P><E><V><F><Q><G><V><E><K><L><V><F><H><M><R><A><Q><H><F><I><F><M><C><P><R><C><G><K><Q><F><N><H><S><S><N><L><N><R><H><M><N><V><H><R><G><V><K><S><H><S><C><G><I><C><G><K><C><F><T><Q><K><S><T><L><H><D><H><L><N><L><H><S><G><A><R><P><Y><R><C><S><Y><C><D><V><R><F><A><H><K><P><A><I><R><R><H><L><K><E><Q><H><G><K><T><T><A><E><N><V><L><E><A><S><V><A><E><I><N><V><L><I><R>
May be involved in transcriptional regulation.<BOP>
Q9Y330
Q5T7M4
ADIPL_HUMAN
Adipolin gCTRP12
Homo
<M><R><R><W><A><W><A><A><V><V><V><L><L><G><P><Q><L><V><L><L><G><G><V><G><A><R><R><E><A><Q><R><T><Q><Q><P><G><Q><R><A><D><P><P><N><A><T><A><S><A><S><S><R><E><G><L><P><E><A><P><K><P><S><Q><A><S><G><P><E><F><S><D><A><H><M><T><W><L><N><F><V><R><R><P><D><D><G><A><L><R><K><R><C><G><S><R><D><K><K><P><R><D><L><F><G><P><P><G><P><P><G><A><E><V><T><A><E><T><L><L><H><E><F><Q><E><L><L><K><E><A><T><E><R><R><F><S><G><L><L><D><P><L><L><P><Q><G><A><G><L><R><L><V><G><E><A><F><H><C><R><L><Q><G><P><R><R><V><D><K><R><T><L><V><E><L><H><G><F><Q><A><P><A><A><Q><G><A><F><L><R><G><S><G><L><S><L><A><S><G><R><F><T><A><P><V><S><G><I><F><Q><F><S><A><S><L><H><V><D><H><S><E><L><Q><G><K><A><R><L><R><A><R><D><V><V><C><V><L><I><C><I><E><S><L><C><Q><R><H><T><C><L><E><A><V><S><G><L><E><S><N><S><R><V><F><T><L><Q><V><Q><G><L><L><Q><L><Q><A><G><Q><Y><A><S><V><F><V><D><N><G><S><G><A><V><L><T><I><Q><A><G><S><S><F><S><G><L><L><L><G><T>
Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.<BOP>
Q5T7M4
P51508
ZNF81_HUMAN
HFZ20
Homo
<M><P><A><N><E><D><A><P><Q><P><G><E><H><G><S><A><C><E><V><S><V><S><F><E><D><V><T><V><D><F><S><R><E><E><W><Q><Q><L><D><S><T><Q><R><R><L><Y><Q><D><V><M><L><E><N><Y><S><H><L><L><S><V><G><F><E><V><P><K><P><E><V><I><F><K><L><E><Q><G><E><G><P><W><T><L><E><G><E><A><P><H><Q><S><C><S><D><G><K><F><G><I><K><P><S><Q><R><R><I><S><G><K><S><T><F><H><S><E><M><E><G><E><D><T><R><D><D><S><L><Y><S><I><L><E><E><L><W><Q><D><A><E><Q><I><K><R><C><Q><E><K><H><N><K><L><L><S><R><T><T><F><L><N><K><K><I><L><N><T><E><W><D><Y><E><Y><K><D><F><G><K><F><V><H><P><S><P><N><L><I><L><S><Q><K><R><P><H><K><R><D><S><F><G><K><S><F><K><H><N><L><D><L><H><I><H><N><K><S><N><A><A><K><N><L><D><K><T><I><G><H><G><Q><V><F><T><Q><N><S><S><Y><S><H><H><E><N><T><H><T><G><V><K><F><C><E><R><N><Q><C><G><K><V><L><S><L><K><H><S><L><S><Q><N><V><K><F><P><I><G><E><K><A><N><T><C><T><E><F><G><K><I><F><T><Q><R><S><H><F><F><A><P><Q><K><I><H><T><V><E><K><P><H><E><L><S><K><C><V><N><V><F><T><Q><K><P><L><L><S><I><Y><L><R><V><H><R><D><E><K><L><Y><I><C><T><K><C><G><K><A><F><I><Q><N><S><E><L><I><M><H><E><K><T><H><T><R><E><K><P><Y><K><C><N><E><C><G><K><S><F><F><Q><V><S><S><L><L><R><H><Q><T><T><H><T><G><E><K><L><F><E><C><S><E><C><G><K><G><F><S><L><N><S><A><L><N><I><H><Q><K><I><H><T><G><E><R><H><H><K><C><S><E><C><G><K><A><F><T><Q><K><S><T><L><R><M><H><Q><R><I><H><T><G><E><R><S><Y><I><C><T><Q><C><G><Q><A><F><I><Q><K><A><H><L><I><A><H><Q><R><I><H><T><G><E><K><P><Y><E><C><S><D><C><G><K><S><F><P><S><K><S><Q><L><Q><M><H><K><R><I><H><T><G><E><K><P><Y><I><C><T><E><C><G><K><A><F><T><N><R><S><N><L><N><T><H><Q><K><S><H><T><G><E><K><S><Y><I><C><A><E><C><G><K><A><F><T><D><R><S><N><F><N><K><H><Q><T><I><H><T><G><E><K><P><Y><V><C><A><D><C><G><R><A><F><I><Q><K><S><E><L><I><T><H><Q><R><I><H><T><T><E><K><P><Y><K><C><P><D><C><E><K><S><F><S><K><K><P><H><L><K><V><H><Q><R><I><H><T><G><E><K><P><Y><I><C><A><E><C><G><K><A><F><T><D><R><S><N><F><N><K><H><Q><T><I><H><T><G><D><K><P><Y><K><C><S><D><C><G><K><G><F><T><Q><K><S><V><L><S><M><H><R><N><I><H><T>
May be involved in transcriptional regulation.<BOP>
P51508
Q8IX05
CD302_HUMAN
Type I transmembrane C-type lectin receptor DCL-1
Homo
<M><L><R><A><A><L><P><A><L><L><L><P><L><L><G><L><A><A><A><A><V><A><D><C><P><S><S><T><W><I><Q><F><Q><D><S><C><Y><I><F><L><Q><E><A><I><K><V><E><S><I><E><D><V><R><N><Q><C><T><D><H><G><A><D><M><I><S><I><H><N><E><E><E><N><A><F><I><L><D><T><L><K><K><Q><W><K><G><P><D><D><I><L><L><G><M><F><Y><D><T><D><D><A><S><F><K><W><F><D><N><S><N><M><T><F><D><K><W><T><D><Q><D><D><D><E><D><L><V><D><T><C><A><F><L><H><I><K><T><G><E><W><K><K><G><N><C><E><V><S><S><V><E><G><T><L><C><K><T><A><I><P><Y><K><R><K><Y><L><S><D><N><H><I><L><I><S><A><L><V><I><A><S><T><V><I><L><T><V><L><G><A><I><I><W><F><L><Y><K><K><H><S><D><S><R><F><T><T><V><F><S><T><A><P><Q><S><P><Y><N><E><D><C><V><L><V><V><G><E><E><N><E><Y><P><V><Q><F><D>
Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.<BOP>
Q8IX05
Q8N414
PGBD5_HUMAN
PiggyBac transposase 5
Homo
<M><A><E><G><G><G><G><A><R><R><R><A><P><A><L><L><E><A><A><R><A><R><Y><E><S><L><H><I><S><D><D><V><F><G><E><S><G><P><D><S><G><G><N><P><F><Y><S><T><S><A><A><S><R><S><S><S><A><A><S><S><D><D><E><R><E><P><P><G><P><P><G><A><A><P><P><P><P><R><A><P><D><A><Q><E><P><E><E><D><E><A><G><A><G><W><S><A><A><L><R><D><R><P><P><P><R><F><E><D><T><G><G><P><T><R><K><M><P><P><S><A><S><A><V><D><F><F><Q><L><F><V><P><D><N><V><L><K><N><M><V><V><Q><T><N><M><Y><A><K><K><F><Q><E><R><F><G><S><D><G><A><W><V><E><V><T><L><T><E><M><K><A><F><L><G><Y><M><I><S><T><S><I><S><H><C><E><S><V><L><S><I><W><S><G><G><F><Y><S><N><R><S><L><A><L><V><M><S><Q><A><R><F><E><K><I><L><K><Y><F><H><V><V><A><F><R><S><S><Q><T><T><H><G><L><Y><K><V><Q><P><F><L><D><S><L><Q><N><S><F><D><S><A><F><R><P><S><Q><T><Q><V><L><H><E><P><L><I><D><E><D><P><V><F><I><A><T><C><T><E><R><E><L><R><K><R><K><K><R><K><F><S><L><W><V><R><Q><C><S><S><T><G><F><I><I><Q><I><Y><V><H><L><K><E><G><G><G><P><D><G><L><D><A><L><K><N><K><P><Q><L><H><S><M><V><A><R><S><L><C><R><N><A><A><G><K><N><Y><I><I><F><T><G><P><S><I><T><S><L><T><L><F><E><E><F><E><K><Q><G><I><Y><C><C><G><L><L><R><A><R><K><S><D><C><T><G><L><P><L><S><M><L><T><N><P><A><T><P><P><A><R><G><Q><Y><Q><I><K><M><K><G><N><M><S><L><I><C><W><Y><N><K><G><H><F><R><F><L><T><N><A><Y><S><P><V><Q><Q><G><V><I><I><K><R><K><S><G><E><I><P><C><P><L><A><V><E><A><F><A><A><H><L><S><Y><I><C><R><Y><D><D><K><Y><S><K><Y><F><I><S><H><K><P><N><K><T><W><Q><Q><V><F><W><F><A><I><S><I><A><I><N><N><A><Y><I><L><Y><K><M><S><D><A><Y><H><V><K><R><Y><S><R><A><Q><F><G><E><R><L><V><R><E><L><L><G><L><E><D><A><S><P><T><H>
Transposase that mediates sequence-specific genomic rearrangements . Can induce genomic rearrangements that inactivate the HPRT1 gene .<BOP>
Q8N414
Q8IUC3
KRA71_HUMAN
High tyrosine-glycine keratin-associated protein 7.1
Homo
<M><T><R><Y><F><C><C><G><S><Y><F><P><G><Y><P><I><Y><G><T><N><F><H><G><T><F><R><A><T><P><L><N><C><V><V><P><L><G><S><P><L><N><Y><G><C><G><C><N><G><Y><S><S><L><G><Y><S><F><G><G><S><N><I><N><N><L><G><G><C><Y><G><G><S><F><Y><R><P><W><G><S><G><S><G><F><G><Y><S><T><Y>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q8IUC3
Q8NET6
CHSTD_HUMAN
Chondroitin 4-sulfotransferase 3
Homo
<M><G><R><R><C><C><R><R><R><V><L><A><A><A><C><L><G><A><A><L><L><L><L><C><A><A><P><R><S><L><R><P><A><F><G><N><R><A><L><G><S><S><W><L><G><G><E><K><R><S><P><L><Q><K><L><Y><D><L><D><Q><D><P><R><S><T><L><A><K><V><H><R><Q><R><R><D><L><L><N><S><A><C><S><R><H><S><R><R><Q><R><L><L><Q><P><E><D><L><R><H><V><L><V><D><D><A><H><G><L><L><Y><C><Y><V><P><K><V><A><C><T><N><W><K><R><V><L><L><A><L><S><G><Q><A><R><G><D><P><R><A><I><S><A><Q><E><A><H><A><P><G><R><L><P><S><L><A><D><F><S><P><A><E><I><N><R><R><L><R><A><Y><L><A><F><L><F><V><R><E><P><F><E><R><L><A><S><A><Y><R><N><K><L><A><R><P><Y><S><A><A><F><Q><R><R><Y><G><A><R><I><V><Q><R><L><R><P><R><A><L><P><D><A><R><A><R><G><H><D><V><R><F><A><E><F><L><A><Y><L><L><D><P><R><T><R><R><E><E><P><F><N><E><H><W><E><R><A><H><A><L><C><H><P><C><R><L><R><Y><D><V><V><G><K><F><E><T><L><A><E><D><A><A><F><V><L><G><L><A><G><A><S><D><L><S><F><P><G><P><P><R><P><R><G><A><A><A><S><R><D><L><A><A><R><L><F><R><D><I><S><P><F><Y><Q><R><R><L><F><D><L><Y><K><M><D><F><L><L><F><N><Y><S><A><P><S><Y><L><R><L><L>
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan.<BOP>
Q8NET6
P57768
SNX16_HUMAN
Sorting nexin-16
Homo
<M><A><T><P><Y><V><P><V><P><M><P><I><G><N><S><A><S><S><F><T><T><N><R><N><Q><R><S><S><S><F><G><S><V><S><T><S><S><N><S><S><K><G><Q><L><E><D><S><N><M><G><N><F><K><Q><T><S><V><P><D><Q><M><D><N><T><S><S><V><C><S><S><P><L><I><R><T><K><F><T><G><T><A><S><S><I><E><Y><S><T><R><P><R><D><T><E><E><Q><N><P><E><T><V><N><W><E><D><R><P><S><T><P><T><I><L><G><Y><E><V><M><E><E><R><A><K><F><T><V><Y><K><I><L><V><K><K><T><P><E><E><S><W><V><V><F><R><R><Y><T><D><F><S><R><L><N><D><K><L><K><E><M><F><P><G><F><R><L><A><L><P><P><K><R><W><F><K><D><N><Y><N><A><D><F><L><E><D><R><Q><L><G><L><Q><A><F><L><Q><N><L><V><A><H><K><D><I><A><N><C><L><A><V><R><E><F><L><C><L><D><D><P><P><G><P><F><D><S><L><E><E><S><R><A><F><C><E><T><L><E><E><T><N><Y><R><L><Q><K><E><L><L><E><K><Q><K><E><M><E><S><L><K><K><L><L><S><E><K><Q><L><H><I><D><T><L><E><N><R><I><R><T><L><S><L><E><P><E><E><S><L><D><V><S><E><T><E><G><E><Q><I><L><K><V><E><S><S><A><L><E><V><D><Q><D><V><L><D><E><E><S><R><A><D><N><K><P><C><L><S><F><S><E><P><E><N><A><V><S><E><I><E><V><A><E><V><A><Y><D><A><E><E><D>
May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.<BOP>
P57768
Q9NVR2
INT10_HUMAN
Integrator complex subunit 10
Homo
<M><S><A><Q><G><D><C><E><F><L><V><Q><R><A><R><E><L><V><P><Q><D><L><W><A><A><K><A><W><L><I><T><A><R><S><L><Y><P><A><D><F><N><I><Q><Y><E><M><Y><T><I><E><R><N><A><E><R><T><A><T><A><G><R><L><L><Y><D><M><F><V><N><F><P><D><Q><P><V><V><W><R><E><I><S><I><I><T><S><A><L><R><N><D><S><Q><D><K><Q><T><Q><F><L><R><S><L><F><E><T><L><P><G><R><V><Q><C><E><M><L><L><K><V><T><E><Q><C><F><N><T><L><E><R><S><E><M><L><L><L><L><L><R><R><F><P><E><T><V><V><Q><H><G><V><G><L><G><E><A><L><L><E><A><E><T><I><E><E><Q><E><S><P><V><N><C><F><R><K><L><F><V><C><D><V><L><P><L><I><I><N><N><H><D><V><R><L><P><A><N><L><L><Y><K><Y><L><N><K><A><A><E><F><Y><I><N><Y><V><T><R><S><T><Q><I><E><N><Q><H><Q><G><A><Q><D><T><S><D><L><M><S><P><S><K><R><S><S><Q><K><Y><I><I><E><G><L><T><E><K><S><S><Q><I><V><D><P><W><E><R><L><F><K><I><L><N><V><V><G><M><R><C><E><W><Q><M><D><K><G><R><R><S><Y><G><D><I><L><H><R><M><K><D><L><C><R><Y><M><N><N><F><D><S><E><A><H><A><K><Y><K><N><Q><V><V><Y><S><T><M><L><V><F><F><K><N><A><F><Q><Y><V><N><S><I><Q><P><S><L><F><Q><G><P><N><A><P><S><Q><V><P><L><V><L><L><E><D><V><S><N><V><Y><G><D><V><E><I><D><R><N><K><H><I><H><K><K><R><K><L><A><E><G><R><E><K><T><M><S><S><D><D><E><D><C><S><A><K><G><R><N><R><H><I><V><V><N><K><A><E><L><A><N><S><T><E><V><L><E><S><F><K><L><A><R><E><S><W><E><L><L><Y><S><L><E><F><L><D><K><E><F><T><R><I><C><L><A><W><K><T><D><T><W><L><W><L><R><I><F><L><T><D><M><I><I><Y><Q><G><Q><Y><K><K><A><I><A><S><L><H><H><L><A><A><L><Q><G><S><I><S><Q><P><Q><I><T><G><Q><G><T><L><E><H><Q><R><A><L><I><Q><L><A><T><C><H><F><A><L><G><E><Y><R><M><T><C><E><K><V><L><D><L><M><C><Y><M><V><L><P><I><Q><D><G><G><K><S><Q><E><E><P><S><K><V><K><P><K><F><R><K><G><S><D><L><K><L><L><P><C><T><S><K><A><I><M><P><Y><C><L><H><L><M><L><A><C><F><K><L><R><A><F><T><D><N><R><D><D><M><A><L><G><H><V><I><V><L><L><Q><Q><E><W><P><R><G><E><N><L><F><L><K><A><V><N><K><I><C><Q><Q><G><N><F><Q><Y><E><N><F><F><N><Y><V><T><N><I><D><M><L><E><E><F><A><Y><L><R><T><Q><E><G><G><K><I><H><L><E><L><L><P><N><Q><G><M><L><I><K><H><H><T><V><T><R><G><I><T><K><G><V><K><E><D><F><R><L><A><M><E><R><Q><V><S><R><C><G><E><N><L><M><V><V><L><H><R><F><C><I><N><E><K><I><L><L><L><Q><T><L><T>
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex .<BOP>
Q9NVR2
Q14353
GAMT_HUMAN
Guanidinoacetate N-methyltransferase
Homo
<M><S><A><P><S><A><T><P><I><F><A><P><G><E><N><C><S><P><A><W><G><A><A><P><A><A><Y><D><A><A><D><T><H><L><R><I><L><G><K><P><V><M><E><R><W><E><T><P><Y><M><H><A><L><A><A><A><A><S><S><K><G><G><R><V><L><E><V><G><F><G><M><A><I><A><A><S><K><V><Q><E><A><P><I><D><E><H><W><I><I><E><C><N><D><G><V><F><Q><R><L><R><D><W><A><P><R><Q><T><H><K><V><I><P><L><K><G><L><W><E><D><V><A><P><T><L><P><D><G><H><F><D><G><I><L><Y><D><T><Y><P><L><S><E><E><T><W><H><T><H><Q><F><N><F><I><K><N><H><A><F><R><L><L><K><P><G><G><V><L><T><Y><C><N><L><T><S><W><G><E><L><M><K><S><K><Y><S><D><I><T><I><M><F><E><E><T><Q><V><P><A><L><L><E><A><G><F><R><R><E><N><I><R><T><E><V><M><A><L><V><P><P><A><D><C><R><Y><Y><A><F><P><Q><M><I><T><P><L><V><T><K><G>
Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor . Important in nervous system development .<BOP>
Q14353
P0DN82
O12D1_HUMAN
Olfactory receptor 12D1
Homo
<M><L><N><T><T><S><V><T><E><F><L><L><L><G><V><T><D><I><Q><E><L><Q><P><F><L><F><V><V><F><L><T><I><Y><F><I><S><V><A><G><N><G><A><I><L><M><I><V><I><S><D><P><R><L><H><S><P><M><Y><F><F><L><G><N><L><S><C><L><D><I><C><Y><S><S><V><T><L><P><K><M><L><Q><N><F><L><S><A><H><K><A><I><S><F><L><G><C><I><S><Q><L><H><F><F><H><F><L><G><S><T><E><A><M><L><L><A><V><M><A><F><D><R><F><V><A><I><C><K><P><L><R><Y><T><V><I><M><N><P><Q><L><C><T><Q><M><A><I><T><I><W><M><I><G><F><F><H><A><L><L><H><S><L><M><T><S><R><L><N><F><C><G><S><N><R><I><Y><H><F><F><C><D><V><K><P><L><L><K><L><A><C><G><N><T><E><L><N><Q><W><L><L><S><T><V><T><G><T><I><A><M><G><P><F><F><L><T><L><L><S><Y><F><Y><I><I><T><H><L><F><F><K><T><H><S><F><S><M><L><R><K><A><L><S><T><C><A><S><H><F><M><V><V><I><L><L><Y><A><P><V><L><F><T><Y><I><H><H><A><S><G><T><S><M><D><Q><D><R><I><T><A><I><M><Y><T><V><V><T><P><V><L><N><P><L><I><Y><T><L><R><N><K><E><V><K><G><A><F><N><R><A><M><K><R><W><L><W><P><K><E><I><L><K><N><S><S><E><A>
Odorant receptor.<BOP>
P0DN82
Q92911
SC5A5_HUMAN
Solute carrier family 5 member 5
Homo
<M><E><A><V><E><T><G><E><R><P><T><F><G><A><W><D><Y><G><V><F><A><L><M><L><L><V><S><T><G><I><G><L><W><V><G><L><A><R><G><G><Q><R><S><A><E><D><F><F><T><G><G><R><R><L><A><A><L><P><V><G><L><S><L><S><A><S><F><M><S><A><V><Q><V><L><G><V><P><S><E><A><Y><R><Y><G><L><K><F><L><W><M><C><L><G><Q><L><L><N><S><V><L><T><A><L><L><F><M><P><V><F><Y><R><L><G><L><T><S><T><Y><E><Y><L><E><M><R><F><S><R><A><V><R><L><C><G><T><L><Q><Y><I><V><A><T><M><L><Y><T><G><I><V><I><Y><A><P><A><L><I><L><N><Q><V><T><G><L><D><I><W><A><S><L><L><S><T><G><I><I><C><T><F><Y><T><A><V><G><G><M><K><A><V><V><W><T><D><V><F><Q><V><V><V><M><L><S><G><F><W><V><V><L><A><R><G><V><M><L><V><G><G><P><R><Q><V><L><T><L><A><Q><N><H><S><R><I><N><L><M><D><F><N><P><D><P><R><S><R><Y><T><F><W><T><F><V><V><G><G><T><L><V><W><L><S><M><Y><G><V><N><Q><A><Q><V><Q><R><Y><V><A><C><R><T><E><K><Q><A><K><L><A><L><L><I><N><Q><V><G><L><F><L><I><V><S><S><A><A><C><C><G><I><V><M><F><V><F><Y><T><D><C><D><P><L><L><L><G><R><I><S><A><P><D><Q><Y><M><P><L><L><V><L><D><I><F><E><D><L><P><G><V><P><G><L><F><L><A><C><A><Y><S><G><T><L><S><T><A><S><T><S><I><N><A><M><A><A><V><T><V><E><D><L><I><K><P><R><L><R><S><L><A><P><R><K><L><V><I><I><S><K><G><L><S><L><I><Y><G><S><A><C><L><T><V><A><A><L><S><S><L><L><G><G><G><V><L><Q><G><S><F><T><V><M><G><V><I><S><G><P><L><L><G><A><F><I><L><G><M><F><L><P><A><C><N><T><P><G><V><L><A><G><L><G><A><G><L><A><L><S><L><W><V><A><L><G><A><T><L><Y><P><P><S><E><Q><T><M><R><V><L><P><S><S><A><A><R><C><V><A><L><S><V><N><A><S><G><L><L><D><P><A><L><L><P><A><N><D><S><S><R><A><P><S><S><G><M><D><A><S><R><P><A><L><A><D><S><F><Y><A><I><S><Y><L><Y><Y><G><A><L><G><T><L><T><T><V><L><C><G><A><L><I><S><C><L><T><G><P><T><K><R><S><T><L><A><P><G><L><L><W><W><D><L><A><R><Q><T><A><S><V><A><P><K><E><E><V><A><I><L><D><D><N><L><V><K><G><P><E><E><L><P><T><G><N><K><K><P><P><G><F><L><P><T><N><E><D><R><L><F><F><L><G><Q><K><E><L><E><G><A><G><S><W><T><P><C><V><G><H><D><G><G><R><D><Q><Q><E><T><N><L>
Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland . Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate .<BOP>
Q92911
P0DTE5
UD2A2_HUMAN
UDP-glucuronosyltransferase 2A2
Homo
<M><V><S><I><R><D><F><T><M><P><K><K><F><V><Q><M><L><V><F><N><L><T><L><T><E><V><V><L><S><G><N><V><L><I><W><P><T><D><G><S><H><W><L><N><I><K><I><I><L><E><E><L><I><Q><R><N><H><N><V><T><V><L><A><S><S><A><T><L><F><I><N><S><N><P><D><S><P><V><N><F><E><V><I><P><V><S><Y><K><K><S><N><I><D><S><L><I><E><H><M><I><M><L><W><I><D><H><R><P><T><P><L><T><I><W><A><F><Y><K><E><L><G><K><L><L><D><T><F><F><Q><I><N><I><Q><L><C><D><G><V><L><K><N><P><K><L><M><A><R><L><Q><K><G><G><F><D><V><L><V><A><D><P><V><T><I><C><G><D><L><V><A><L><K><L><G><I><P><F><M><Y><T><L><R><F><S><P><A><S><T><V><E><R><H><C><G><K><I><P><A><P><V><S><Y><V><P><A><A><L><S><E><L><T><D><Q><M><T><F><G><E><R><I><K><N><T><I><S><Y><S><L><Q><D><Y><I><F><Q><S><Y><W><G><E><W><N><S><Y><Y><S><K><I><L><G><R><P><T><T><L><C><E><T><M><G><K><A><E><I><W><L><I><R><T><Y><W><D><F><E><F><P><R><P><Y><L><P><N><F><E><F><V><G><G><L><H><C><K><P><A><K><P><L><P><K><E><M><E><E><F><I><Q><S><S><G><K><N><G><V><V><V><F><S><L><G><S><M><V><K><N><L><T><E><E><K><A><N><L><I><A><S><A><L><A><Q><I><P><Q><K><V><L><W><R><Y><K><G><K><K><P><A><T><L><G><N><N><T><Q><L><F><D><W><I><P><Q><N><D><L><L><G><H><P><K><T><K><A><F><I><T><H><G><G><T><N><G><I><Y><E><A><I><Y><H><G><V><P><M><V><G><V><P><M><F><A><D><Q><P><D><N><I><A><H><M><K><A><K><G><A><A><V><E><V><N><L><N><T><M><T><S><V><D><L><L><S><A><L><R><T><V><I><N><E><P><S><Y><K><E><N><A><M><R><L><S><R><I><H><H><D><Q><P><V><K><P><L><D><R><A><V><F><W><I><E><F><V><M><R><H><K><G><A><K><H><L><R><V><A><A><H><D><L><T><W><F><Q><Y><H><S><L><D><V><I><G><F><L><L><V><C><V><T><T><A><I><F><L><V><I><Q><C><C><L><F><S><C><Q><K><F><G><K><I><G><K><K><K><K><R><E>
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile . Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds . Catalyzes the glucuronidation of endogenous estrogen hormone estradiol . Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption . Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth .<BOP>
P0DTE5
P01562
IFNA1_HUMAN
Interferon alpha-D
Homo
<M><A><S><P><F><A><L><L><M><V><L><V><V><L><S><C><K><S><S><C><S><L><G><C><D><L><P><E><T><H><S><L><D><N><R><R><T><L><M><L><L><A><Q><M><S><R><I><S><P><S><S><C><L><M><D><R><H><D><F><G><F><P><Q><E><E><F><D><G><N><Q><F><Q><K><A><P><A><I><S><V><L><H><E><L><I><Q><Q><I><F><N><L><F><T><T><K><D><S><S><A><A><W><D><E><D><L><L><D><K><F><C><T><E><L><Y><Q><Q><L><N><D><L><E><A><C><V><M><Q><E><E><R><V><G><E><T><P><L><M><N><A><D><S><I><L><A><V><K><K><Y><F><R><R><I><T><L><Y><L><T><E><K><K><Y><S><P><C><A><W><E><V><V><R><A><E><I><M><R><S><L><S><L><S><T><N><L><Q><E><R><L><R><R><K><E>
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.<BOP>
P01562
Q8N4T4
ARG39_HUMAN
Rho guanine nucleotide exchange factor 39
Homo
<M><E><L><S><C><P><G><S><R><C><P><V><Q><E><Q><R><A><R><W><E><R><K><R><A><C><T><A><R><E><L><L><E><T><E><R><R><Y><Q><E><Q><L><G><L><V><A><T><Y><F><L><G><I><L><K><A><K><G><T><L><R><P><P><E><R><Q><A><L><F><G><S><W><E><L><I><Y><G><A><S><Q><E><L><L><P><Y><L><E><G><G><C><W><G><Q><G><L><E><G><F><C><R><H><L><E><L><Y><N><Q><F><A><A><N><S><E><R><S><Q><T><T><L><Q><E><Q><L><K><K><N><K><G><F><R><R><F><V><R><L><Q><E><G><R><P><E><F><G><G><L><Q><L><Q><D><L><L><P><L><P><L><Q><R><L><Q><Q><Y><E><N><L><V><V><A><L><A><E><N><T><G><P><N><S><P><D><H><Q><Q><L><T><R><A><A><R><L><I><S><E><T><A><Q><R><V><H><T><I><G><Q><K><Q><K><N><D><Q><H><L><R><R><V><Q><A><L><L><S><G><R><Q><A><K><G><L><T><S><G><R><W><F><L><R><Q><G><W><L><L><V><V><P><P><H><G><E><P><R><P><R><M><F><F><L><F><T><D><V><L><L><M><A><K><P><R><P><P><L><H><L><L><R><S><G><T><F><A><C><K><A><L><Y><P><M><A><Q><C><H><L><S><R><V><F><G><H><S><G><G><P><C><G><G><L><L><S><L><S><F><P><H><E><K><L><L><L><M><S><T><D><Q><E><E><L><S><R><W><Y><H><S><L><T><W><A><I><S><S><Q><K><N>
Promotes cell proliferation.<BOP>
Q8N4T4
O14926
FSCN2_HUMAN
Retinal fascin
Homo
<M><P><T><N><G><L><H><Q><V><L><K><I><Q><F><G><L><V><N><D><T><D><R><Y><L><T><A><E><S><F><G><F><K><V><N><A><S><A><P><S><L><K><R><K><Q><T><W><V><L><E><P><D><P><G><Q><G><T><A><V><L><L><R><S><S><H><L><G><R><Y><L><S><A><E><E><D><G><R><V><A><C><E><A><E><Q><P><G><R><D><C><R><F><L><V><L><P><Q><P><D><G><R><W><V><L><R><S><E><P><H><G><R><F><F><G><G><T><E><D><Q><L><S><C><F><A><T><A><V><S><P><A><E><L><W><T><V><H><L><A><I><H><P><Q><A><H><L><L><S><V><S><R><R><R><Y><V><H><L><C><P><R><E><D><E><M><A><A><D><G><D><K><P><W><G><V><D><A><L><L><T><L><I><F><R><S><R><R><Y><C><L><K><S><C><D><S><R><Y><L><R><S><D><G><R><L><V><W><E><P><E><P><R><A><C><Y><T><L><E><F><K><A><G><K><L><A><F><K><D><C><D><G><H><Y><L><A><P><V><G><P><A><G><T><L><K><A><G><R><N><T><R><P><G><K><D><E><L><F><D><L><E><E><S><H><P><Q><V><V><L><V><A><A><N><H><R><Y><V><S><V><R><Q><G><V><N><V><S><A><N><Q><D><D><E><L><D><H><E><T><F><L><M><Q><I><D><Q><E><T><K><K><C><T><F><Y><S><S><T><G><G><Y><W><T><L><V><T><H><G><G><I><H><A><T><A><T><Q><V><S><A><N><T><M><F><E><M><E><W><R><G><R><R><V><A><L><K><A><S><N><G><R><Y><V><C><M><K><K><N><G><Q><L><A><A><I><S><D><F><V><G><K><D><E><E><F><T><L><K><L><I><N><R><P><I><L><V><L><R><G><L><D><G><F><V><C><H><H><R><G><S><N><Q><L><D><T><N><R><S><V><Y><D><V><F><H><L><S><F><S><D><G><A><Y><R><I><R><G><R><D><G><G><F><W><Y><T><G><S><H><G><S><V><C><S><D><G><E><R><A><E><D><F><V><F><E><F><R><E><R><G><R><L><A><I><R><A><R><S><G><K><Y><L><R><G><G><A><S><G><L><L><R><A><D><A><D><A><P><A><G><T><A><L><W><E><Y>
Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.<BOP>
O14926
P08217
CEL2A_HUMAN
Elastase-2A
Homo
<M><I><R><T><L><L><L><S><T><L><V><A><G><A><L><S><C><G><D><P><T><Y><P><P><Y><V><T><R><V><V><G><G><E><E><A><R><P><N><S><W><P><W><Q><V><S><L><Q><Y><S><S><N><G><K><W><Y><H><T><C><G><G><S><L><I><A><N><S><W><V><L><T><A><A><H><C><I><S><S><S><R><T><Y><R><V><G><L><G><R><H><N><L><Y><V><A><E><S><G><S><L><A><V><S><V><S><K><I><V><V><H><K><D><W><N><S><N><Q><I><S><K><G><N><D><I><A><L><L><K><L><A><N><P><V><S><L><T><D><K><I><Q><L><A><C><L><P><P><A><G><T><I><L><P><N><N><Y><P><C><Y><V><T><G><W><G><R><L><Q><T><N><G><A><V><P><D><V><L><Q><Q><G><R><L><L><V><V><D><Y><A><T><C><S><S><S><A><W><W><G><S><S><V><K><T><S><M><I><C><A><G><G><D><G><V><I><S><S><C><N><G><D><S><G><G><P><L><N><C><Q><A><S><D><G><R><W><Q><V><H><G><I><V><S><F><G><S><R><L><G><C><N><Y><Y><H><K><P><S><V><F><T><R><V><S><N><Y><I><D><W><I><N><S><V><I><A><N><N>
Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity.<BOP>
P08217
Q8N0Y2
ZN444_HUMAN
Zinc finger and SCAN domain-containing protein 17
Homo
<M><E><V><A><V><P><V><K><Q><E><A><E><G><L><A><L><D><S><P><W><H><R><F><R><R><F><H><L><G><D><A><P><G><P><R><E><A><L><G><L><L><R><A><L><C><R><D><W><L><R><P><E><V><H><T><K><E><Q><M><L><E><L><L><V><L><E><Q><F><L><S><A><L><P><A><D><T><Q><A><W><V><C><S><R><Q><P><Q><S><G><E><E><A><V><A><L><L><E><E><L><W><G><P><A><A><S><P><D><G><S><S><A><T><R><V><P><Q><D><V><T><Q><G><P><G><A><T><G><G><K><E><D><S><G><M><I><P><L><A><G><T><A><P><G><A><E><G><P><A><P><G><D><S><Q><A><V><R><P><Y><K><Q><E><P><S><S><P><P><L><A><P><G><L><P><A><F><L><A><A><P><G><T><T><S><C><P><E><C><G><K><T><S><L><K><P><A><H><L><L><R><H><R><Q><S><H><S><G><E><K><P><H><A><C><P><E><C><G><K><A><F><R><R><K><E><H><L><R><R><H><R><D><T><H><P><G><S><P><G><S><P><G><P><A><L><R><P><L><P><A><R><E><K><P><H><A><C><C><E><C><G><K><T><F><Y><W><R><E><H><L><V><R><H><R><K><T><H><S><G><A><R><P><F><A><C><W><E><C><G><K><G><F><G><R><R><E><H><V><L><R><H><Q><R><I><H><G><R><A><A><A><S><A><Q><G><A><V><A><P><G><P><D><G><G><G><P><F><P><P><W><P><L><G>
Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter.<BOP>
Q8N0Y2
Q8TBM8
DJB14_HUMAN
DnaJ homolog subfamily B member 14
Homo
<M><E><G><N><R><D><E><A><E><K><C><V><E><I><A><R><E><A><L><N><A><G><N><R><E><K><A><Q><R><F><L><Q><K><A><E><K><L><Y><P><L><P><S><A><R><A><L><L><E><I><I><M><K><N><G><S><T><A><G><N><S><P><H><C><R><K><P><S><G><S><G><D><Q><S><K><P><N><C><T><K><D><S><T><S><G><S><G><E><G><G><K><G><Y><T><K><D><Q><V><D><G><V><L><S><I><N><K><C><K><N><Y><Y><E><V><L><G><V><T><K><D><A><G><D><E><D><L><K><K><A><Y><R><K><L><A><L><K><F><H><P><D><K><N><H><A><P><G><A><T><D><A><F><K><K><I><G><N><A><Y><A><V><L><S><N><P><E><K><R><K><Q><Y><D><L><T><G><N><E><E><Q><A><C><N><H><Q><N><N><G><R><F><N><F><H><R><G><C><E><A><D><I><T><P><E><D><L><F><N><I><F><F><G><G><G><F><P><S><G><S><V><H><S><F><S><N><G><R><A><G><Y><S><Q><Q><H><Q><H><R><H><S><G><H><E><R><E><E><E><R><G><D><G><G><F><S><V><F><I><Q><L><M><P><I><I><V><L><I><L><V><S><L><L><S><Q><L><M><V><S><N><P><P><Y><S><L><Y><P><R><S><G><T><G><Q><T><I><K><M><Q><T><E><N><L><G><V><V><Y><Y><V><N><K><D><F><K><N><E><Y><K><G><M><L><L><Q><K><V><E><K><S><V><E><E><D><Y><V><T><N><I><R><N><N><C><W><K><E><R><Q><Q><K><T><D><M><Q><Y><A><A><K><V><Y><R><D><D><R><L><R><R><K><A><D><A><L><S><M><D><N><C><K><E><L><E><R><L><T><S><L><Y><K><G><G>
(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection .<BOP>
Q8TBM8
P04921
GLPC_HUMAN
Sialoglycoprotein D
Homo
<M><W><S><T><R><S><P><N><S><T><A><W><P><L><S><L><E><P><D><P><G><M><A><S><A><S><T><T><M><H><T><T><T><I><A><E><P><D><P><G><M><S><G><W><P><D><G><R><M><E><T><S><T><P><T><I><M><D><I><V><V><I><A><G><V><I><A><A><V><A><I><V><L><V><S><L><L><F><V><M><L><R><Y><M><Y><R><H><K><G><T><Y><H><T><N><E><A><K><G><T><E><F><A><E><S><A><D><A><A><L><Q><G><D><P><A><L><Q><D><A><G><D><S><S><R><K><E><Y><F><I>
This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.<BOP>
P04921
Q99645
EPYC_HUMAN
Small chondroitin/dermatan sulfate proteoglycan
Homo
<M><K><T><L><A><G><L><V><L><G><L><V><I><F><D><A><A><V><T><A><P><T><L><E><S><I><N><Y><D><S><E><T><Y><D><A><T><L><E><D><L><D><N><L><Y><N><Y><E><N><I><P><V><D><K><V><E><I><E><I><A><T><V><M><P><S><G><N><R><E><L><L><T><P><P><P><Q><P><E><K><A><Q><E><E><E><E><E><E><E><S><T><P><R><L><I><D><G><S><S><P><Q><E><P><E><F><T><G><V><L><G><P><H><T><N><E><D><F><P><T><C><L><L><C><T><C><I><S><T><T><V><Y><C><D><D><H><E><L><D><A><I><P><P><L><P><K><N><T><A><Y><F><Y><S><R><F><N><R><I><K><K><I><N><K><N><D><F><A><S><L><S><D><L><K><R><I><D><L><T><S><N><L><I><S><E><I><D><E><D><A><F><R><K><L><P><Q><L><R><E><L><V><L><R><D><N><K><I><R><Q><L><P><E><L><P><T><T><L><T><F><I><D><I><S><N><N><R><L><G><R><K><G><I><K><Q><E><A><F><K><D><M><Y><D><L><H><H><L><Y><L><T><D><N><N><L><D><H><I><P><L><P><L><P><E><N><L><R><A><L><H><L><Q><N><N><N><I><L><E><M><H><E><D><T><F><C><N><V><K><N><L><T><Y><I><R><K><A><L><E><D><I><R><L><D><G><N><P><I><N><L><S><K><T><P><Q><A><Y><M><C><L><P><R><L><P><V><G><S><L><V>
May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.<BOP>
Q99645
Q99767
APBA2_HUMAN
Neuronal Munc18-1-interacting protein 2
Homo
<M><A><H><R><K><L><E><S><V><G><S><G><M><L><D><H><R><V><R><P><G><P><V><P><H><S><Q><E><P><E><S><E><D><M><E><L><P><L><E><G><Y><V><P><E><G><L><E><L><A><A><L><R><P><E><S><P><A><P><E><E><Q><E><C><H><N><H><S><P><D><G><D><S><S><S><D><Y><V><N><N><T><S><E><E><E><D><Y><D><E><G><L><P><E><E><E><E><G><I><T><Y><Y><I><R><Y><C><P><E><D><D><S><Y><L><E><G><M><D><C><N><G><E><E><Y><L><A><H><S><A><H><P><V><D><T><D><E><C><Q><E><A><V><E><E><W><T><D><S><A><G><P><H><P><H><G><H><E><A><E><G><S><Q><D><Y><P><D><G><Q><L><P><I><P><E><D><E><P><S><V><L><E><A><H><D><Q><E><E><D><G><H><Y><C><A><S><K><E><G><Y><Q><D><Y><Y><P><E><E><A><N><G><N><T><G><A><S><P><Y><R><L><R><R><G><D><G><D><L><E><D><Q><E><E><D><I><D><Q><I><V><A><E><I><K><M><S><L><S><M><T><S><I><T><S><A><S><E><A><S><P><E><H><G><P><E><P><G><P><E><D><S><V><E><A><C><P><P><I><K><A><S><C><S><P><S><R><H><E><A><R><P><K><S><L><N><L><L><P><E><A><K><H><P><G><D><P><Q><R><G><F><K><P><K><T><R><T><P><E><E><R><L><K><W><P><H><E><Q><V><C><N><G><L><E><Q><P><R><K><Q><Q><R><S><D><L><N><G><P><V><D><N><N><N><I><P><E><T><K><K><V><A><S><F><P><S><F><V><A><V><P><G><P><C><E><P><E><D><L><I><D><G><I><I><F><A><A><N><Y><L><G><S><T><Q><L><L><S><E><R><N><P><S><K><N><I><R><M><M><Q><A><Q><E><A><V><S><R><V><K><R><M><Q><K><A><A><K><I><K><K><K><A><N><S><E><G><D><A><Q><T><L><T><E><V><D><L><F><I><S><T><Q><R><I><K><V><L><N><A><D><T><Q><E><T><M><M><D><H><A><L><R><T><I><S><Y><I><A><D><I><G><N><I><V><V><L><M><A><R><R><R><M><P><R><S><A><S><Q><D><C><I><E><T><T><P><G><A><Q><E><G><K><K><Q><Y><K><M><I><C><H><V><F><E><S><E><D><A><Q><L><I><A><Q><S><I><G><Q><A><F><S><V><A><Y><Q><E><F><L><R><A><N><G><I><N><P><E><D><L><S><Q><K><E><Y><S><D><I><I><N><T><Q><E><M><Y><N><D><D><L><I><H><F><S><N><S><E><N><C><K><E><L><Q><L><E><K><H><K><G><E><I><L><G><V><V><V><V><E><S><G><W><G><S><I><L><P><T><V><I><L><A><N><M><M><N><G><G><P><A><A><R><S><G><K><L><S><I><G><D><Q><I><M><S><I><N><G><T><S><L><V><G><L><P><L><A><T><C><Q><G><I><I><K><G><L><K><N><Q><T><Q><V><K><L><N><I><V><S><C><P><P><V><T><T><V><L><I><K><R><P><D><L><K><Y><Q><L><G><F><S><V><Q><N><G><I><I><C><S><L><M><R><G><G><I><A><E><R><G><G><V><R><V><G><H><R><I><I><E><I><N><G><Q><S><V><V><A><T><A><H><E><K><I><V><Q><A><L><S><N><S><V><G><E><I><H><M><K><T><M><P><A><A><M><F><R><L><L><T><G><Q><E><T><P><L><Y><I>
Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.<BOP>
Q99767
P21695
GPDA_HUMAN
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
Homo
<M><A><S><K><K><V><C><I><V><G><S><G><N><W><G><S><A><I><A><K><I><V><G><G><N><A><A><Q><L><A><Q><F><D><P><R><V><T><M><W><V><F><E><E><D><I><G><G><K><K><L><T><E><I><I><N><T><Q><H><E><N><V><K><Y><L><P><G><H><K><L><P><P><N><V><V><A><V><P><D><V><V><Q><A><A><E><D><A><D><I><L><I><F><V><V><P><H><Q><F><I><G><K><I><C><D><Q><L><K><G><H><L><K><A><N><A><T><G><I><S><L><I><K><G><V><D><E><G><P><N><G><L><K><L><I><S><E><V><I><G><E><R><L><G><I><P><M><S><V><L><M><G><A><N><I><A><S><E><V><A><D><E><K><F><C><E><T><T><I><G><C><K><D><P><A><Q><G><Q><L><L><K><E><L><M><Q><T><P><N><F><R><I><T><V><V><Q><E><V><D><T><V><E><I><C><G><A><L><K><N><V><V><A><V><G><A><G><F><C><D><G><L><G><F><G><D><N><T><K><A><A><V><I><R><L><G><L><M><E><M><I><A><F><A><K><L><F><C><S><G><P><V><S><S><A><T><F><L><E><S><C><G><V><A><D><L><I><T><T><C><Y><G><G><R><N><R><K><V><A><E><A><F><A><R><T><G><K><S><I><E><Q><L><E><K><E><L><L><N><G><Q><K><L><Q><G><P><E><T><A><R><E><L><Y><S><I><L><Q><H><K><G><L><V><D><K><F><P><L><F><M><A><V><Y><K><V><C><Y><E><G><Q><P><V><G><E><F><I><H><C><L><Q><N><H><P><E><H><M>
Has glycerol-3-phosphate dehydrogenase activity.<BOP>
P21695
Q9UHV5
RPGFL_HUMAN
Link guanine nucleotide exchange factor II
Homo
<M><K><P><L><E><K><F><L><K><K><Q><T><S><Q><L><A><G><R><T><V><A><G><G><P><G><G><G><L><G><S><C><G><G><P><G><G><G><G><G><P><G><G><G><G><G><P><A><G><G><Q><R><S><L><Q><R><R><Q><S><V><S><R><L><L><L><P><A><F><L><R><E><P><P><A><E><P><G><L><E><P><P><V><P><E><E><G><G><E><P><A><G><V><A><E><E><P><G><S><G><G><P><C><W><L><Q><L><E><E><V><P><G><P><G><P><L><G><G><G><G><P><L><R><S><P><S><S><Y><S><S><D><E><L><S><P><G><E><P><L><T><S><P><P><W><A><P><L><G><A><P><E><R><P><E><H><L><L><N><R><V><L><E><R><L><A><G><G><A><T><R><D><S><A><A><S><D><I><L><L><D><D><I><V><L><T><H><S><L><F><L><P><T><E><K><F><L><Q><E><L><H><Q><Y><F><V><R><A><G><G><M><E><G><P><E><G><L><G><R><K><Q><A><C><L><A><M><L><L><H><F><L><D><T><Y><Q><G><L><L><Q><E><E><E><G><A><G><H><I><I><K><D><L><Y><L><L><I><M><K><D><E><S><L><Y><Q><G><L><R><E><D><T><L><R><L><H><Q><L><V><E><T><V><E><L><K><I><P><E><E><N><Q><P><P><S><K><Q><V><K><P><L><F><R><H><F><R><R><I><D><S><C><L><Q><T><R><V><A><F><R><G><S><D><E><I><F><C><R><V><Y><M><P><D><H><S><Y><V><T><I><R><S><R><L><S><A><S><V><Q><D><I><L><G><S><V><T><E><K><L><Q><Y><S><E><E><P><A><G><R><E><D><S><L><I><L><V><A><V><S><S><S><G><E><K><V><L><L><Q><P><T><E><D><C><V><F><T><A><L><G><I><N><S><H><L><F><A><C><T><R><D><S><Y><E><A><L><V><P><L><P><E><E><I><Q><V><S><P><G><D><T><E><I><H><R><V><E><P><E><D><V><A><N><H><L><T><A><F><H><W><E><L><F><R><C><V><H><E><L><E><F><V><D><Y><V><F><H><G><E><R><G><R><R><E><T><A><N><L><E><L><L><L><Q><R><C><S><E><V><T><H><W><V><A><T><E><V><L><L><C><E><A><P><G><K><R><A><Q><L><L><K><K><F><I><K><I><A><A><L><C><K><Q><N><Q><D><L><L><S><F><Y><A><V><V><M><G><L><D><N><A><A><V><S><R><L><R><L><T><W><E><K><L><P><G><K><F><K><N><L><F><R><K><F><E><N><L><T><D><P><C><R><N><H><K><S><Y><R><E><V><I><S><K><M><K><P><P><V><I><P><F><V><P><L><I><L><K><D><L><T><F><L><H><E><G><S><K><T><L><V><D><G><L><V><N><I><E><K><L><H><S><V><A><E><K><V><R><T><I><R><K><Y><R><S><R><P><L><C><L><D><M><E><A><S><P><N><H><L><Q><T><K><A><Y><V><R><Q><F><Q><V><I><D><N><Q><N><L><L><F><E><L><S><Y><K><L><E><A><N><S><Q>
Probable guanine nucleotide exchange factor (GEF).<BOP>
Q9UHV5
P60413
KR10C_HUMAN
Keratin-associated protein 18.12
Homo
<M><S><V><C><S><S><D><L><S><Y><G><S><R><V><C><L><P><G><S><C><D><S><C><S><D><S><W><Q><V><D><D><C><P><E><S><C><C><E><P><P><C><C><A><P><A><P><C><L><S><L><V><C><T><P><V><S><R><V><S><S><P><C><C><R><V><T><C><E><P><S><P><C><Q><S><G><C><T><S><S><C><T><P><S><C><C><Q><Q><S><S><C><Q><P><A><C><C><T><S><S><P><C><Q><Q><A><C><C><V><P><V><C><C><K><T><V><C><C><K><P><V><C><C><M><P><V><C><C><G><P><S><S><S><C><C><Q><Q><S><S><C><Q><P><A><C><C><I><S><S><P><C><Q><Q><S><C><C><V><P><V><C><C><K><P><I><C><C><V><P><V><C><S><G><A><S><S><L><C><C><Q><Q><S><S><C><Q><P><A><C><C><T><T><S><C><C><R><P><S><S><S><V><S><L><L><C><R><P><V><C><R><P><A><R><R><V><P><V><P><S><C><C><V><P><T><S><S><C><Q><P><S><C><G><R><L><A><S><C><G><S><L><L><C><R><P><T><C><S><R><L><A><C>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
P60413
Q7Z628
ARHG8_HUMAN
Rho guanine nucleotide exchange factor 8
Homo
<M><E><P><E><L><A><A><Q><K><Q><P><R><P><R><R><R><S><R><R><A><S><G><L><S><T><E><G><A><T><G><P><S><A><D><T><S><G><S><E><L><D><G><R><C><S><L><R><R><G><S><S><F><T><F><L><T><P><G><P><N><W><D><F><T><L><K><R><K><R><R><E><K><D><D><D><V><V><S><L><S><S><L><D><L><K><E><P><S><N><K><R><V><R><P><L><A><R><V><T><S><L><A><N><L><I><S><P><V><R><N><G><A><V><R><R><F><G><Q><T><I><Q><S><F><T><L><R><G><D><H><R><S><P><A><S><A><Q><K><F><S><S><R><S><T><V><P><T><P><A><K><R><R><S><S><A><L><W><S><E><M><L><D><I><T><M><K><E><S><L><T><T><R><E><I><R><R><Q><E><A><I><Y><E><M><S><R><G><E><Q><D><L><I><E><D><L><K><L><A><R><K><A><Y><H><D><P><M><L><K><L><S><I><M><S><E><E><E><L><T><H><I><F><G><D><L><D><S><Y><I><P><L><H><E><D><L><L><T><R><I><G><E><A><T><K><P><D><G><T><V><E><Q><I><G><H><I><L><V><S><W><L><P><R><L><N><A><Y><R><G><Y><C><S><N><Q><L><A><A><K><A><L><L><D><Q><K><K><Q><D><P><R><V><Q><D><F><L><Q><R><C><L><E><S><P><F><S><R><K><L><D><L><W><S><F><L><D><I><P><R><S><R><L><V><K><Y><P><L><L><L><K><E><I><L><K><H><T><P><K><E><H><P><D><V><Q><L><L><E><D><A><I><L><I><I><Q><G><V><L><S><D><I><N><L><K><K><G><E><S><E><C><Q><Y><Y><I><D><K><L><E><Y><L><D><E><K><Q><R><D><P><R><I><E><A><S><K><V><L><L><C><H><G><E><L><R><S><K><S><G><H><K><L><Y><I><F><L><F><Q><D><I><L><V><L><T><R><P><V><T><R><N><E><R><H><S><Y><Q><V><Y><R><Q><P><I><P><V><Q><E><L><V><L><E><D><L><Q><D><G><D><V><R><M><G><G><S><F><R><G><A><F><S><N><S><E><K><A><K><N><I><F><R><I><R><F><H><D><P><S><P><A><Q><S><H><T><L><Q><A><N><D><V><F><H><K><Q><Q><W><F><N><C><I><R><A><A><I><A><P><F><Q><S><A><G><S><P><P><E><L><Q><G><L><P><E><L><H><E><E><C><E><G><N><H><P><S><A><R><K><L><T><A><Q><R><R><A><S><T><V><S><S><V><T><Q><V><E><V><D><E><N><A><Y><R><C><G><S><G><M><Q><M><A><E><D><S><K><S><L><K><T><H><Q><T><Q><P><G><I><R><R><A><R><D><K><A><L><S><G><G><K><R><K><E><T><L><V>
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.<BOP>
Q7Z628
O14519
CDKA1_HUMAN
Putative oral cancer suppressor
Homo
<M><S><Y><K><P><N><L><A><A><H><M><P><A><A><A><L><N><A><A><G><S><V><H><S><P><S><T><S><M><A><T><S><S><Q><Y><R><Q><L><L><S><D><Y><G><P><P><S><L><G><Y><T><Q><G><T><G><N><S><Q><V><P><Q><S><K><Y><A><E><L><L><A><I><I><E><E><L><G><K><E><I><R><P><T><Y><A><G><S><K><S><A><M><E><R><L><K><R><G><I><I><H><A><R><G><L><V><R><E><C><L><A><E><T><E><R><N><A><R><S>
specific inhibitor of the cell-cycle kinase CDK2.<BOP>
O14519
Q92685
ALG3_HUMAN
Not56-like protein
Homo
<M><A><A><G><L><R><K><R><G><R><S><G><S><A><A><Q><A><E><G><L><C><K><Q><W><L><Q><R><A><W><Q><E><R><R><L><L><L><R><E><P><R><Y><T><L><L><V><A><A><C><L><C><L><A><E><V><G><I><T><F><W><V><I><H><R><V><A><Y><T><E><I><D><W><K><A><Y><M><A><E><V><E><G><V><I><N><G><T><Y><D><Y><T><Q><L><Q><G><D><T><G><P><L><V><Y><P><A><G><F><V><Y><I><F><M><G><L><Y><Y><A><T><S><R><G><T><D><I><R><M><A><Q><N><I><F><A><V><L><Y><L><A><T><L><L><L><V><F><L><I><Y><H><Q><T><C><K><V><P><P><F><V><F><F><F><M><C><C><A><S><Y><R><V><H><S><I><F><V><L><R><L><F><N><D><P><V><A><M><V><L><L><F><L><S><I><N><L><L><L><A><Q><R><W><G><W><G><C><C><F><F><S><L><A><V><S><V><K><M><N><V><L><L><F><A><P><G><L><L><F><L><L><L><T><Q><F><G><F><R><G><A><L><P><K><L><G><I><C><A><G><L><Q><V><V><L><G><L><P><F><L><L><E><N><P><S><G><Y><L><S><R><S><F><D><L><G><R><Q><F><L><F><H><W><T><V><N><W><R><F><L><P><E><A><L><F><L><H><R><A><F><H><L><A><L><L><T><A><H><L><T><L><L><L><L><F><A><L><C><R><W><H><R><T><G><E><S><I><L><S><L><L><R><D><P><S><K><R><K><V><P><P><Q><P><L><T><P><N><Q><I><V><S><T><L><F><T><S><N><F><I><G><I><C><F><S><R><S><L><H><Y><Q><F><Y><V><W><Y><F><H><T><L><P><Y><L><L><W><A><M><P><A><R><W><L><T><H><L><L><R><L><L><V><L><G><L><I><E><L><S><W><N><T><Y><P><S><T><S><C><S><S><A><A><L><H><I><C><H><A><V><I><L><L><Q><L><W><L><G><P><Q><P><F><P><K><S><T><Q><H><S><K><K><A><H>
Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol.<BOP>
Q92685
Q8IVT2
MISP_HUMAN
Mitotic spindle positioning protein
Homo
<M><D><R><V><T><R><Y><P><I><L><G><I><P><Q><A><H><R><G><T><G><L><V><L><D><G><D><T><S><Y><T><Y><H><L><V><C><M><G><P><E><A><S><G><W><G><Q><D><E><P><Q><T><W><P><T><D><H><R><A><Q><Q><G><V><Q><R><Q><G><V><S><Y><S><V><H><A><Y><T><G><Q><P><S><P><R><G><L><H><S><E><N><R><E><D><E><G><W><Q><V><Y><R><L><G><A><R><D><A><H><Q><G><R><P><T><W><A><L><R><P><E><D><G><E><D><K><E><M><K><T><Y><R><L><D><A><G><D><A><D><P><R><R><L><C><D><L><E><R><E><R><W><A><V><I><Q><G><Q><A><V><R><K><S><S><T><V><A><T><L><Q><G><T><P><D><H><G><D><P><R><T><P><G><P><P><R><S><T><P><L><E><E><N><V><V><D><R><E><Q><I><D><F><L><A><A><R><Q><Q><F><L><S><L><E><Q><A><N><K><G><A><P><H><S><S><P><A><R><G><T><P><A><G><T><T><P><G><A><S><Q><A><P><K><A><F><N><K><P><H><L><A><N><G><H><V><V><P><I><K><P><Q><V><K><G><V><V><R><E><E><N><K><V><R><A><V><P><T><W><A><S><V><Q><V><V><D><D><P><G><S><L><A><S><V><E><S><P><G><T><P><K><E><T><P><I><E><R><E><I><R><L><A><Q><E><R><E><A><D><L><R><E><Q><R><G><L><R><Q><A><T><D><H><Q><E><L><V><E><I><P><T><R><P><L><L><T><K><L><S><L><I><T><A><P><R><R><E><R><G><R><P><S><L><Y><V><Q><R><D><I><V><Q><E><T><Q><R><E><E><D><H><R><R><E><G><L><H><V><G><R><A><S><T><P><D><W><V><S><E><G><P><Q><P><G><L><R><R><A><L><S><S><D><S><I><L><S><P><A><P><D><A><R><A><A><D><P><A><P><E><V><R><K><V><N><R><I><P><P><D><A><Y><Q><P><Y><L><S><P><G><T><P><Q><L><E><F><S><A><F><G><A><F><G><K><P><S><S><L><S><T><A><E><A><K><A><A><T><S><P><K><A><T><M><S><P><R><H><L><S><E><S><S><G><K><P><L><S><T><K><Q><E><A><S><K><P><P><R><G><C><P><Q><A><N><R><G><V><V><R><W><E><Y><F><R><L><R><P><L><R><F><R><A><P><D><E><P><Q><Q><A><Q><V><P><H><V><W><G><W><E><V><A><G><A><P><A><L><R><L><Q><K><S><Q><S><S><D><L><L><E><R><E><R><E><S><V><L><R><R><E><Q><E><V><A><E><E><R><R><N><A><L><F><P><E><V><F><S><P><T><P><D><E><N><S><D><Q><N><S><R><S><S><S><Q><A><S><G><I><T><G><S><Y><S><V><S><E><S><P><F><F><S><P><I><H><L><H><S><N><V><A><W><T><V><E><D><P><V><D><S><A><P><P><G><Q><R><K><K><E><Q><W><Y><A><G><I><N><P><S><D><G><I><N><S><E><V><L><E><A><I><R><V><T><R><H><K><N><A><M><A><E><R><W><E><S><R><I><Y><A><S><E><E><D><D>
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.<BOP>
Q8IVT2
P24534
EF1B_HUMAN
Elongation factor 1-beta
Homo
<M><G><F><G><D><L><K><S><P><A><G><L><Q><V><L><N><D><Y><L><A><D><K><S><Y><I><E><G><Y><V><P><S><Q><A><D><V><A><V><F><E><A><V><S><S><P><P><P><A><D><L><C><H><A><L><R><W><Y><N><H><I><K><S><Y><E><K><E><K><A><S><L><P><G><V><K><K><A><L><G><K><Y><G><P><A><D><V><E><D><T><T><G><S><G><A><T><D><S><K><D><D><D><D><I><D><L><F><G><S><D><D><E><E><E><S><E><E><A><K><R><L><R><E><E><R><L><A><Q><Y><E><S><K><K><A><K><K><P><A><L><V><A><K><S><S><I><L><L><D><V><K><P><W><D><D><E><T><D><M><A><K><L><E><E><C><V><R><S><I><Q><A><D><G><L><V><W><G><S><S><K><L><V><P><V><G><Y><G><I><K><K><L><Q><I><Q><C><V><V><E><D><D><K><V><G><T><D><M><L><E><E><Q><I><T><A><F><E><D><Y><V><Q><S><M><D><V><A><A><F><N><K><I>
EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.<BOP>
P24534
Q6UWY2
PRS57_HUMAN
Serine protease 1-like protein 1
Homo
<M><G><L><G><L><R><G><W><G><R><P><L><L><T><V><A><T><A><L><M><L><P><V><K><P><P><A><G><S><W><G><A><Q><I><I><G><G><H><E><V><T><P><H><S><R><P><Y><M><A><S><V><R><F><G><G><Q><H><H><C><G><G><F><L><L><R><A><R><W><V><V><S><A><A><H><C><F><S><H><R><D><L><R><T><G><L><V><V><L><G><A><H><V><L><S><T><A><E><P><T><Q><Q><V><F><G><I><D><A><L><T><T><H><P><D><Y><H><P><M><T><H><A><N><D><I><C><L><L><R><L><N><G><S><A><V><L><G><P><A><V><G><L><L><R><P><P><G><R><R><A><R><P><P><T><A><G><T><R><C><R><V><A><G><W><G><F><V><S><D><F><E><E><L><P><P><G><L><M><E><A><K><V><R><V><L><D><P><D><V><C><N><S><S><W><K><G><H><L><T><L><T><M><L><C><T><R><S><G><D><S><H><R><R><G><F><C><S><A><D><S><G><G><P><L><V><C><R><N><R><A><H><G><L><V><S><F><S><G><L><W><C><G><D><P><K><T><P><D><V><Y><T><Q><V><S><A><F><V><A><W><I><W><D><V><V><R><R><S><S><P><Q><P><G><P><L><P><G><T><T><R><P><P><G><E><A><A>
Serine protease that cleaves preferentially after Arg residues . Can also cleave after citrulline (deimidated arginine) and methylarginine residues .<BOP>
Q6UWY2
Q9H1M3
DB129_HUMAN
Defensin, beta 129
Homo
<M><K><L><L><F><P><I><F><A><S><L><M><L><Q><Y><Q><V><N><T><E><F><I><G><L><R><R><C><L><M><G><L><G><R><C><R><D><H><C><N><V><D><E><K><E><I><Q><K><C><K><M><K><K><C><C><V><G><P><K><V><V><K><L><I><K><N><Y><L><Q><Y><G><T><P><N><V><L><N><E><D><V><Q><E><M><L><K><P><A><K><N><S><S><A><V><I><Q><R><K><H><I><L><S><V><L><P><Q><I><K><S><T><S><F><F><A><N><T><N><F><V><I><I><P><N><A><T><P><M><N><S><A><T><I><S><T><M><T><P><G><Q><I><T><Y><T><A><T><S><T><K><S><N><T><K><E><S><R><D><S><A><T><A><S><P><P><P><A><P><P><P><P><N><I><L><P><T><P><S><L><E><L><E><E><A><E><E><Q>
Has antibacterial activity.<BOP>
Q9H1M3
Q8NBF2
NHLC2_HUMAN
NHL repeat-containing protein 2
Homo
<M><A><A><P><G><G><R><G><R><S><L><S><G><L><L><P><A><Q><T><S><L><E><Y><A><L><L><D><A><V><T><Q><Q><E><K><D><S><L><V><Y><Q><Y><L><Q><K><V><D><G><W><E><Q><D><L><S><V><P><E><F><P><E><G><L><E><W><L><N><T><E><E><P><I><S><V><Y><K><D><L><C><G><K><I><V><V><L><D><F><F><T><Y><C><C><I><N><C><I><H><L><L><P><D><L><H><A><L><E><H><T><Y><S><D><K><D><G><L><L><I><I><G><V><H><S><A><K><F><P><N><E><K><V><L><D><N><I><K><S><A><V><L><R><Y><N><I><T><H><P><M><V><N><D><A><D><A><S><L><W><Q><E><L><E><V><S><C><W><P><T><L><V><I><L><G><P><R><G><N><M><L><F><S><L><I><G><E><G><H><K><D><K><L><F><L><Y><T><S><I><A><L><K><Y><Y><K><D><R><G><Q><I><R><D><N><K><I><G><I><K><L><Y><K><D><S><L><P><P><S><P><L><L><F><P><G><K><V><T><V><D><Q><V><T><D><R><L><V><I><A><D><T><G><H><H><R><I><L><V><V><W><K><N><G><Q><I><Q><Y><S><I><G><G><P><N><P><G><R><K><D><G><I><F><S><E><S><T><F><N><S><P><Q><G><V><A><I><M><N><N><I><I><Y><V><A><D><T><E><N><H><L><I><R><K><I><D><L><E><A><E><K><V><S><T><V><A><G><I><G><I><Q><G><T><D><K><E><G><G><A><K><G><E><Q><Q><P><I><S><S><P><W><D><V><V><F><G><T><S><G><S><E><V><Q><R><G><D><I><L><W><I><A><M><A><G><T><H><Q><I><W><A><L><L><L><D><S><G><K><L><P><K><K><N><E><L><T><K><G><T><C><L><R><F><A><G><S><G><N><E><E><N><R><N><N><A><Y><P><H><K><A><G><F><A><Q><P><S><G><L><S><L><A><S><E><D><P><W><S><C><L><F><V><A><D><S><E><S><S><T><V><R><T><V><S><L><K><D><G><A><V><K><H><L><V><G><G><E><R><D><P><M><N><L><F><A><F><G><D><V><D><G><V><G><I><N><A><K><L><Q><H><P><L><G><V><T><W><D><K><K><R><N><L><L><Y><V><A><D><S><Y><N><H><K><I><K><V><V><D><P><K><T><K><N><C><T><T><L><A><G><T><G><D><T><N><N><V><T><S><S><S><F><T><E><S><T><F><N><E><P><G><G><L><C><I><G><E><N><G><E><L><L><Y><V><A><D><T><N><N><H><Q><I><K><V><M><D><L><E><T><K><M><V><S><V><L><P><I><F><R><S><E><N><A><V><V><D><G><P><F><L><V><E><K><Q><K><T><L><P><K><L><P><K><S><A><P><S><I><R><L><S><P><V><T><A><C><A><G><Q><T><L><Q><F><K><L><R><L><D><L><P><S><G><S><K><L><T><E><G><V><S><S><C><W><F><L><T><A><E><G><N><E><W><L><L><Q><G><Q><I><A><A><G><D><I><E><N><I><S><S><Q><P><T><I><S><L><Q><I><P><D><D><C><L><S><L><E><A><I><V><S><V><S><V><F><L><Y><Y><C><S><A><D><S><S><A><C><M><M><K><A><I><L><F><S><Q><P><L><Q><I><T><D><T><Q><Q><G><C><I><A><P><V><E><L><R><Y><V><F>
Required for normal embryonic development.<BOP>
Q8NBF2
Q9NP55
BPIA1_HUMAN
Von Ebner protein Hl
Homo
<M><F><Q><T><G><G><L><I><V><F><Y><G><L><L><A><Q><T><M><A><Q><F><G><G><L><P><V><P><L><D><Q><T><L><P><L><N><V><N><P><A><L><P><L><S><P><T><G><L><A><G><S><L><T><N><A><L><S><N><G><L><L><S><G><G><L><L><G><I><L><E><N><L><P><L><L><D><I><L><K><P><G><G><G><T><S><G><G><L><L><G><G><L><L><G><K><V><T><S><V><I><P><G><L><N><N><I><I><D><I><K><V><T><D><P><Q><L><L><E><L><G><L><V><Q><S><P><D><G><H><R><L><Y><V><T><I><P><L><G><I><K><L><Q><V><N><T><P><L><V><G><A><S><L><L><R><L><A><V><K><L><D><I><T><A><E><I><L><A><V><R><D><K><Q><E><R><I><H><L><V><L><G><D><C><T><H><S><P><G><S><L><Q><I><S><L><L><D><G><L><G><P><L><P><I><Q><G><L><L><D><S><L><T><G><I><L><N><K><V><L><P><E><L><V><Q><G><N><V><C><P><L><V><N><E><V><L><R><G><L><D><I><T><L><V><H><D><I><V><N><M><L><I><H><G><L><Q><F><V><I><K><V>
Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) . Plays a role in the innate immune responses of the upper airways . Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae . Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus . Plays a role in the airway inflammatory response after exposure to irritants . May attract macrophages and neutrophils .<BOP>
Q9NP55
A6NDH6
O5H15_HUMAN
Olfactory receptor 5H15
Homo
<M><E><E><E><N><A><T><L><L><T><E><F><V><L><T><G><F><L><Y><Q><P><Q><W><K><I><P><L><F><L><A><F><L><V><I><Y><L><I><T><I><M><G><N><L><G><L><I><A><V><I><W><K><D><P><H><L><H><I><P><M><Y><L><L><L><G><N><L><A><F><V><D><A><W><I><S><S><T><V><T><P><K><M><L><N><N><F><L><A><K><S><K><M><I><S><L><S><E><C><K><I><Q><F><F><S><I><A><I><G><V><T><T><E><C><F><L><L><A><T><M><A><Y><D><R><Y><V><A><I><C><K><P><L><L><Y><P><A><I><M><T><N><G><L><C><I><R><L><L><I><L><S><Y><I><A><G><I><L><H><A><L><I><H><E><G><F><L><F><R><L><T><F><C><N><S><N><I><V><H><H><I><Y><C><D><T><I><P><L><S><K><I><S><C><T><D><S><S><I><N><F><L><M><V><F><I><F><S><G><S><I><Q><V><F><S><I><V><T><I><L><I><S><Y><T><F><V><L><F><T><V><L><E><K><K><S><D><K><G><V><R><K><A><F><S><T><C><G><A><H><L><F><S><V><C><L><Y><Y><G><P><L><L><L><M><Y><V><G><P><A><S><P><Q><A><D><G><Q><N><M><V><E><P><L><F><Y><T><V><I><I><P><L><L><N><P><I><I><Y><S><L><R><N><K><Q><V><I><V><S><F><I><K><M><L><K><R><N><V><K><V><S><Y>
Odorant receptor.<BOP>
A6NDH6
P0CJ72
HMN5_HUMAN
MT-RNR2-like protein 5
Homo
<M><A><T><P><G><F><S><C><L><L><L><S><T><S><E><I><D><L><P><M><K><R><R><V>
Plays a role as a neuroprotective and antiapoptotic factor.<BOP>
P0CJ72
Q9Y6B2
EID1_HUMAN
E1A-like inhibitor of differentiation 1
Homo
<M><S><E><M><A><E><L><S><E><L><Y><E><E><S><S><D><L><Q><M><D><V><M><P><G><E><G><D><L><P><Q><M><E><V><G><S><G><S><R><E><L><S><L><R><P><S><R><S><G><A><Q><Q><L><E><E><E><G><P><M><E><E><E><E><A><Q><P><M><A><A><P><E><G><K><R><S><L><A><N><G><P><N><A><G><E><Q><P><G><Q><V><A><G><A><D><F><E><S><E><D><E><G><E><E><F><D><D><W><E><D><D><Y><D><Y><P><E><E><E><Q><L><S><G><A><G><Y><R><V><S><A><A><L><E><E><A><D><K><M><F><L><R><T><R><E><P><A><L><D><G><G><F><Q><M><H><Y><E><K><T><P><F><D><Q><L><A><F><I><E><E><L><F><S><L><M><V><V><N><R><L><T><E><E><L><G><C><D><E><I><I><D><R><E>
Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.<BOP>
Q9Y6B2
Q96CS3
FAF2_HUMAN
UBX domain-containing protein 8
Homo
<M><A><A><P><E><E><R><D><L><T><Q><E><Q><T><E><K><L><L><Q><F><Q><D><L><T><G><I><E><S><M><D><Q><C><R><H><T><L><E><Q><H><N><W><N><I><E><A><A><V><Q><D><R><L><N><E><Q><E><G><V><P><S><V><F><N><P><P><P><S><R><P><L><Q><V><N><T><A><D><H><R><I><Y><S><Y><V><V><S><R><P><Q><P><R><G><L><L><G><W><G><Y><Y><L><I><M><L><P><F><R><F><T><Y><Y><T><I><L><D><I><F><R><F><A><L><R><F><I><R><P><D><P><R><S><R><V><T><D><P><V><G><D><I><V><S><F><M><H><S><F><E><E><K><Y><G><R><A><H><P><V><F><Y><Q><G><T><Y><S><Q><A><L><N><D><A><K><R><E><L><R><F><L><L><V><Y><L><H><G><D><D><H><Q><D><S><D><E><F><C><R><N><T><L><C><A><P><E><V><I><S><L><I><N><T><R><M><L><F><W><A><C><S><T><N><K><P><E><G><Y><R><V><S><Q><A><L><R><E><N><T><Y><P><F><L><A><M><I><M><L><K><D><R><R><M><T><V><V><G><R><L><E><G><L><I><Q><P><D><D><L><I><N><Q><L><T><F><I><M><D><A><N><Q><T><Y><L><V><S><E><R><L><E><R><E><E><R><N><Q><T><Q><V><L><R><Q><Q><Q><D><E><A><Y><L><A><S><L><R><A><D><Q><E><K><E><R><K><K><R><E><E><R><E><R><K><R><R><K><E><E><E><V><Q><Q><Q><K><L><A><E><E><R><R><R><Q><N><L><Q><E><E><K><E><R><K><L><E><C><L><P><P><E><P><S><P><D><D><P><E><S><V><K><I><I><F><K><L><P><N><D><S><R><V><E><R><R><F><H><F><S><Q><S><L><T><V><I><H><D><F><L><F><S><L><K><E><S><P><E><K><F><Q><I><E><A><N><F><P><R><R><V><L><P><C><I><P><S><E><E><W><P><N><P><P><T><L><Q><E><A><G><L><S><H><T><E><V><L><F><V><Q><D><L><T><D><E>
Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins . By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway . Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis .<BOP>
Q96CS3
O60542
PSPN_HUMAN
Persephin
Homo
<M><A><V><G><K><F><L><L><G><S><L><L><L><L><S><L><Q><L><G><Q><G><W><G><P><D><A><R><G><V><P><V><A><D><G><E><F><S><S><E><Q><V><A><K><A><G><G><T><W><L><G><T><H><R><P><L><A><R><L><R><R><A><L><S><G><P><C><Q><L><W><S><L><T><L><S><V><A><E><L><G><L><G><Y><A><S><E><E><K><V><I><F><R><Y><C><A><G><S><C><P><R><G><A><R><T><Q><H><G><L><A><L><A><R><L><Q><G><Q><G><R><A><H><G><G><P><C><C><R><P><T><R><Y><T><D><V><A><F><L><D><D><R><H><R><W><Q><R><L><P><Q><L><S><A><A><A><C><G><C><G><G>
Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.<BOP>
O60542
Q10713
MPPA_HUMAN
P-55
Homo
<M><A><A><V><V><L><A><A><T><R><L><L><R><G><S><G><S><W><G><C><S><R><L><R><F><G><P><P><A><Y><R><R><F><S><S><G><G><A><Y><P><N><I><P><L><S><S><P><L><P><G><V><P><K><P><V><F><A><T><V><D><G><Q><E><K><F><E><T><K><V><T><T><L><D><N><G><L><R><V><A><S><Q><N><K><F><G><Q><F><C><T><V><G><I><L><I><N><S><G><S><R><Y><E><A><K><Y><L><S><G><I><A><H><F><L><E><K><L><A><F><S><S><T><A><R><F><D><S><K><D><E><I><L><L><T><L><E><K><H><G><G><I><C><D><C><Q><T><S><R><D><T><T><M><Y><A><V><S><A><D><S><K><G><L><D><T><V><V><A><L><L><A><D><V><V><L><Q><P><R><L><T><D><E><E><V><E><M><T><R><M><A><V><Q><F><E><L><E><D><L><N><L><R><P><D><P><E><P><L><L><T><E><M><I><H><E><A><A><Y><R><E><N><T><V><G><L><H><R><F><C><P><T><E><N><V><A><K><I><N><R><E><V><L><H><S><Y><L><R><N><Y><Y><T><P><D><R><M><V><L><A><G><V><G><V><E><H><E><H><L><V><D><C><A><R><K><Y><L><L><G><V><Q><P><A><W><G><S><A><E><A><V><D><I><D><R><S><V><A><Q><Y><T><G><G><I><A><K><L><E><R><D><M><S><N><V><S><L><G><P><T><P><I><P><E><L><T><H><I><M><V><G><L><E><S><C><S><F><L><E><E><D><F><I><P><F><A><V><L><N><M><M><M><G><G><G><G><S><F><S><A><G><G><P><G><K><G><M><F><S><R><L><Y><L><N><V><L><N><R><H><H><W><M><Y><N><A><T><S><Y><H><H><S><Y><E><D><T><G><L><L><C><I><H><A><S><A><D><P><R><Q><V><R><E><M><V><E><I><I><T><K><E><F><I><L><M><G><G><T><V><D><T><V><E><L><E><R><A><K><T><Q><L><T><S><M><L><M><M><N><L><E><S><R><P><V><I><F><E><D><V><G><R><Q><V><L><A><T><R><S><R><K><L><P><H><E><L><C><T><L><I><R><N><V><K><P><E><D><V><K><R><V><A><S><K><M><L><R><G><K><P><A><V><A><A><L><G><D><L><T><D><L><P><T><Y><E><H><I><Q><T><A><L><S><S><K><D><G><R><L><P><R><T><Y><R><L><F><R>
Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.<BOP>
Q10713
Q9BY10
TSCOT_HUMAN
Solute carrier family 46 member 2
Homo
<M><S><P><E><V><T><C><P><R><R><G><H><L><P><R><F><H><P><R><T><W><V><E><P><V><V><A><S><S><Q><V><A><A><S><L><Y><D><A><G><L><L><L><V><V><K><A><S><Y><G><T><G><G><S><S><N><H><S><A><S><P><S><P><R><G><A><L><E><D><Q><Q><Q><R><A><I><S><N><F><Y><I><I><Y><N><L><V><V><G><L><S><P><L><L><S><A><Y><G><L><G><W><L><S><D><R><Y><H><R><K><I><S><I><C><M><S><L><L><G><F><L><L><S><R><L><G><L><L><L><K><V><L><L><D><W><P><V><E><V><L><Y><G><A><A><A><L><N><G><L><F><G><G><F><S><A><F><W><S><G><V><M><A><L><G><S><L><G><S><S><E><G><R><R><S><V><R><L><I><L><I><D><L><M><L><G><L><A><G><F><C><G><S><M><A><S><G><H><L><F><K><Q><M><A><G><H><S><G><Q><G><L><I><L><T><A><C><S><V><S><C><A><S><F><A><L><L><Y><S><L><L><V><L><K><V><P><E><S><V><A><K><P><S><Q><E><L><P><A><V><D><T><V><S><G><T><V><G><T><Y><R><T><L><D><P><D><Q><L><D><Q><Q><Y><A><V><G><H><P><P><S><P><G><K><A><K><P><H><K><T><T><I><A><L><L><F><V><G><A><I><I><Y><D><L><A><V><V><G><T><V><D><V><I><P><L><F><V><L><R><E><P><L><G><W><N><Q><V><Q><V><G><Y><G><M><A><A><G><Y><T><I><F><I><T><S><F><L><G><V><L><V><F><S><R><C><F><R><D><T><T><M><I><M><I><G><M><V><S><F><G><S><G><A><L><L><L><A><F><V><K><E><T><Y><M><F><Y><I><A><R><A><V><M><L><F><A><L><I><P><V><T><T><I><R><S><A><M><S><K><L><I><K><G><S><S><Y><G><K><V><F><V><I><L><Q><L><S><L><A><L><T><G><V><V><T><S><T><L><Y><N><K><I><Y><Q><L><T><M><D><M><F><V><G><S><C><F><A><L><S><S><F><L><S><F><L><A><I><I><P><I><S><I><V><A><Y><K><Q><V><P><L><S><P><Y><G><D><I><I><E><K>
May act as a transporter.<BOP>
Q9BY10
Q3LI77
KR134_HUMAN
Keratin-associated protein 13-4
Homo
<M><S><Y><N><C><C><S><R><N><F><S><S><R><S><F><G><G><Y><L><Y><Y><P><G><S><Y><P><S><S><L><V><Y><S><T><A><L><C><S><P><S><T><C><Q><L><R><S><S><L><Y><R><D><C><Q><K><T><C><W><E><P><A><S><C><Q><K><S><C><Y><R><P><R><T><S><I><L><C><C><P><C><Q><T><T><C><S><G><S><L><G><F><R><S><S><S><C><R><S><Q><G><Y><G><S><R><C><C><Y><S><L><G><N><G><S><S><G><F><R><F><L><K><Y><G><G><C><G><F><P><S><L><S><Y><G><S><R><F><C><Y><P><N><Y><L><A><S><G><A><W><Q><S><S><C><Y><R><P><I><C><G><S><R><F><Y><Q><F><T><C>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q3LI77
P32881
IFNA8_HUMAN
Interferon alpha-B2
Homo
<M><A><L><T><F><Y><L><L><V><A><L><V><V><L><S><Y><K><S><F><S><S><L><G><C><D><L><P><Q><T><H><S><L><G><N><R><R><A><L><I><L><L><A><Q><M><R><R><I><S><P><F><S><C><L><K><D><R><H><D><F><E><F><P><Q><E><E><F><D><D><K><Q><F><Q><K><A><Q><A><I><S><V><L><H><E><M><I><Q><Q><T><F><N><L><F><S><T><K><D><S><S><A><A><L><D><E><T><L><L><D><E><F><Y><I><E><L><D><Q><Q><L><N><D><L><E><S><C><V><M><Q><E><V><G><V><I><E><S><P><L><M><Y><E><D><S><I><L><A><V><R><K><Y><F><Q><R><I><T><L><Y><L><T><E><K><K><Y><S><S><C><A><W><E><V><V><R><A><E><I><M><R><S><F><S><L><S><I><N><L><Q><K><R><L><K><S><K><E>
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.<BOP>
P32881
P31943
HNRH1_HUMAN
Heterogeneous nuclear ribonucleoprotein H, N-terminally processed
Homo
<M><M><L><G><T><E><G><G><E><G><F><V><V><K><V><R><G><L><P><W><S><C><S><A><D><E><V><Q><R><F><F><S><D><C><K><I><Q><N><G><A><Q><G><I><R><F><I><Y><T><R><E><G><R><P><S><G><E><A><F><V><E><L><E><S><E><D><E><V><K><L><A><L><K><K><D><R><E><T><M><G><H><R><Y><V><E><V><F><K><S><N><N><V><E><M><D><W><V><L><K><H><T><G><P><N><S><P><D><T><A><N><D><G><F><V><R><L><R><G><L><P><F><G><C><S><K><E><E><I><V><Q><F><F><S><G><L><E><I><V><P><N><G><I><T><L><P><V><D><F><Q><G><R><S><T><G><E><A><F><V><Q><F><A><S><Q><E><I><A><E><K><A><L><K><K><H><K><E><R><I><G><H><R><Y><I><E><I><F><K><S><S><R><A><E><V><R><T><H><Y><D><P><P><R><K><L><M><A><M><Q><R><P><G><P><Y><D><R><P><G><A><G><R><G><Y><N><S><I><G><R><G><A><G><F><E><R><M><R><R><G><A><Y><G><G><G><Y><G><G><Y><D><D><Y><N><G><Y><N><D><G><Y><G><F><G><S><D><R><F><G><R><D><L><N><Y><C><F><S><G><M><S><D><H><R><Y><G><D><G><G><S><T><F><Q><S><T><T><G><H><C><V><H><M><R><G><L><P><Y><R><A><T><E><N><D><I><Y><N><F><F><S><P><L><N><P><V><R><V><H><I><E><I><G><P><D><G><R><V><T><G><E><A><D><V><E><F><A><T><H><E><D><A><V><A><A><M><S><K><D><K><A><N><M><Q><H><R><Y><V><E><L><F><L><N><S><T><A><G><A><S><G><G><A><Y><E><H><R><Y><V><E><L><F><L><N><S><T><A><G><A><S><G><G><A><Y><G><S><Q><M><M><G><G><M><G><L><S><N><Q><S><S><Y><G><G><P><A><S><Q><Q><L><S><G><G><Y><G><G><G><Y><G><G><Q><S><S><M><S><G><Y><D><Q><V><L><Q><E><N><S><S><D><F><Q><S><N><I><A>
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).<BOP>
P31943
P31391
SSR4_HUMAN
Somatostatin receptor type 4
Homo
<M><S><A><P><S><T><L><P><P><G><G><E><E><G><L><G><T><A><W><P><S><A><A><N><A><S><S><A><P><A><E><A><E><E><A><V><A><G><P><G><D><A><R><A><A><G><M><V><A><I><Q><C><I><Y><A><L><V><C><L><V><G><L><V><G><N><A><L><V><I><F><V><I><L><R><Y><A><K><M><K><T><A><T><N><I><Y><L><L><N><L><A><V><A><D><E><L><F><M><L><S><V><P><F><V><A><S><S><A><A><L><R><H><W><P><F><G><S><V><L><C><R><A><V><L><S><V><D><G><L><N><M><F><T><S><V><F><C><L><T><V><L><S><V><D><R><Y><V><A><V><V><H><P><L><R><A><A><T><Y><R><R><P><S><V><A><K><L><I><N><L><G><V><W><L><A><S><L><L><V><T><L><P><I><A><I><F><A><D><T><R><P><A><R><G><G><Q><A><V><A><C><N><L><Q><W><P><H><P><A><W><S><A><V><F><V><V><Y><T><F><L><L><G><F><L><L><P><V><L><A><I><G><L><C><Y><L><L><I><V><G><K><M><R><A><V><A><L><R><A><G><W><Q><Q><R><R><R><S><E><K><K><I><T><R><L><V><L><M><V><V><V><V><F><V><L><C><W><M><P><F><Y><V><V><Q><L><L><N><L><F><V><T><S><L><D><A><T><V><N><H><V><S><L><I><L><S><Y><A><N><S><C><A><N><P><I><L><Y><G><F><L><S><D><N><F><R><R><F><F><Q><R><V><L><C><L><R><C><C><L><L><E><G><A><G><G><A><E><E><E><P><L><D><Y><Y><A><T><A><L><K><S><K><G><G><A><G><C><M><C><P><P><L><P><C><Q><Q><E><A><L><Q><P><E><P><G><R><K><R><I><P><L><T><R><T><T><T><F>
Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.<BOP>
P31391
Q765I0
UTS2B_HUMAN
Urotensin-2 domain-containing protein
Homo
<M><N><K><I><L><S><S><T><V><C><F><G><L><L><T><L><L><S><V><L><S><F><L><Q><S><V><H><G><R><P><Y><L><T><Q><G><N><E><I><F><P><D><K><K><Y><T><N><R><E><E><L><L><L><A><L><L><N><K><N><F><D><F><Q><R><P><F><N><T><D><L><A><L><P><N><K><L><E><E><L><N><Q><L><E><K><L><K><E><Q><L><V><E><E><K><D><S><E><T><S><Y><A><V><D><G><L><F><S><S><H><P><S><K><R><A><C><F><W><K><Y><C><V>
Potent vasoconstrictor.<BOP>
Q765I0
P28062
PSB8_HUMAN
Really interesting new gene 10 protein
Homo
<M><A><L><L><D><V><C><G><A><P><R><G><Q><R><P><E><S><A><L><P><V><A><G><S><G><R><R><S><D><P><G><H><Y><S><F><S><M><R><S><P><E><L><A><L><P><R><G><M><Q><P><T><E><F><F><Q><S><L><G><G><D><G><E><R><N><V><Q><I><E><M><A><H><G><T><T><T><L><A><F><K><F><Q><H><G><V><I><A><A><V><D><S><R><A><S><A><G><S><Y><I><S><A><L><R><V><N><K><V><I><E><I><N><P><Y><L><L><G><T><M><S><G><C><A><A><D><C><Q><Y><W><E><R><L><L><A><K><E><C><R><L><Y><Y><L><R><N><G><E><R><I><S><V><S><A><A><S><K><L><L><S><N><M><M><C><Q><Y><R><G><M><G><L><S><M><G><S><M><I><C><G><W><D><K><K><G><P><G><L><Y><Y><V><D><E><H><G><T><R><L><S><G><N><M><F><S><T><G><S><G><N><T><Y><A><Y><G><V><M><D><S><G><Y><R><P><N><L><S><P><E><E><A><Y><D><L><G><R><R><A><I><A><Y><A><T><H><R><D><S><Y><S><G><G><V><V><N><M><Y><H><M><K><E><D><G><W><V><K><V><E><S><T><D><V><S><D><L><L><H><Q><Y><R><E><A><N><Q>
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein . Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.<BOP>
P28062
Q12794
HYAL1_HUMAN
Lung carcinoma protein 1
Homo
<M><A><A><H><L><L><P><I><C><A><L><F><L><T><L><L><D><M><A><Q><G><F><R><G><P><L><L><P><N><R><P><F><T><T><V><W><N><A><N><T><Q><W><C><L><E><R><H><G><V><D><V><D><V><S><V><F><D><V><V><A><N><P><G><Q><T><F><R><G><P><D><M><T><I><F><Y><S><S><Q><L><G><T><Y><P><Y><Y><T><P><T><G><E><P><V><F><G><G><L><P><Q><N><A><S><L><I><A><H><L><A><R><T><F><Q><D><I><L><A><A><I><P><A><P><D><F><S><G><L><A><V><I><D><W><E><A><W><R><P><R><W><A><F><N><W><D><T><K><D><I><Y><R><Q><R><S><R><A><L><V><Q><A><Q><H><P><D><W><P><A><P><Q><V><E><A><V><A><Q><D><Q><F><Q><G><A><A><R><A><W><M><A><G><T><L><Q><L><G><R><A><L><R><P><R><G><L><W><G><F><Y><G><F><P><D><C><Y><N><Y><D><F><L><S><P><N><Y><T><G><Q><C><P><S><G><I><R><A><Q><N><D><Q><L><G><W><L><W><G><Q><S><R><A><L><Y><P><S><I><Y><M><P><A><V><L><E><G><T><G><K><S><Q><M><Y><V><Q><H><R><V><A><E><A><F><R><V><A><V><A><A><G><D><P><N><L><P><V><L><P><Y><V><Q><I><F><Y><D><T><T><N><H><F><L><P><L><D><E><L><E><H><S><L><G><E><S><A><A><Q><G><A><A><G><V><V><L><W><V><S><W><E><N><T><R><T><K><E><S><C><Q><A><I><K><E><Y><M><D><T><T><L><G><P><F><I><L><N><V><T><S><G><A><L><L><C><S><Q><A><L><C><S><G><H><G><R><C><V><R><R><T><S><H><P><K><A><L><L><L><L><N><P><A><S><F><S><I><Q><L><T><P><G><G><G><P><L><S><L><R><G><A><L><S><L><E><D><Q><A><Q><M><A><V><E><F><K><C><R><C><Y><P><G><W><Q><A><P><W><C><E><R><K><S><M><W>
May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.<BOP>
Q12794
Q9UKM7
MA1B1_HUMAN
Mannosidase alpha class 1B member 1
Homo
<M><A><A><C><E><G><R><R><S><G><A><L><G><S><S><Q><S><D><F><L><T><P><P><V><G><G><A><P><W><A><V><A><T><T><V><V><M><Y><P><P><P><P><P><P><P><H><R><D><F><I><S><V><T><L><S><F><G><E><N><Y><D><N><S><K><S><W><R><R><R><S><C><W><R><K><W><K><Q><L><S><R><L><Q><R><N><M><I><L><F><L><L><A><F><L><L><F><C><G><L><L><F><Y><I><N><L><A><D><H><W><K><A><L><A><F><R><L><E><E><E><Q><K><M><R><P><E><I><A><G><L><K><P><A><N><P><P><V><L><P><A><P><Q><K><A><D><T><D><P><E><N><L><P><E><I><S><S><Q><K><T><Q><R><H><I><Q><R><G><P><P><H><L><Q><I><R><P><P><S><Q><D><L><K><D><G><T><Q><E><E><A><T><K><R><Q><E><A><P><V><D><P><R><P><E><G><D><P><Q><R><T><V><I><S><W><R><G><A><V><I><E><P><E><Q><G><T><E><L><P><S><R><R><A><E><V><P><T><K><P><P><L><P><P><A><R><T><Q><G><T><P><V><H><L><N><Y><R><Q><K><G><V><I><D><V><F><L><H><A><W><K><G><Y><R><K><F><A><W><G><H><D><E><L><K><P><V><S><R><S><F><S><E><W><F><G><L><G><L><T><L><I><D><A><L><D><T><M><W><I><L><G><L><R><K><E><F><E><E><A><R><K><W><V><S><K><K><L><H><F><E><K><D><V><D><V><N><L><F><E><S><T><I><R><I><L><G><G><L><L><S><A><Y><H><L><S><G><D><S><L><F><L><R><K><A><E><D><F><G><N><R><L><M><P><A><F><R><T><P><S><K><I><P><Y><S><D><V><N><I><G><T><G><V><A><H><P><P><R><W><T><S><D><S><T><V><A><E><V><T><S><I><Q><L><E><F><R><E><L><S><R><L><T><G><D><K><K><F><Q><E><A><V><E><K><V><T><Q><H><I><H><G><L><S><G><K><K><D><G><L><V><P><M><F><I><N><T><H><S><G><L><F><T><H><L><G><V><F><T><L><G><A><R><A><D><S><Y><Y><E><Y><L><L><K><Q><W><I><Q><G><G><K><Q><E><T><Q><L><L><E><D><Y><V><E><A><I><E><G><V><R><T><H><L><L><R><H><S><E><P><S><K><L><T><F><V><G><E><L><A><H><G><R><F><S><A><K><M><D><H><L><V><C><F><L><P><G><T><L><A><L><G><V><Y><H><G><L><P><A><S><H><M><E><L><A><Q><E><L><M><E><T><C><Y><Q><M><N><R><Q><M><E><T><G><L><S><P><E><I><V><H><F><N><L><Y><P><Q><P><G><R><R><D><V><E><V><K><P><A><D><R><H><N><L><L><R><P><E><T><V><E><S><L><F><Y><L><Y><R><V><T><G><D><R><K><Y><Q><D><W><G><W><E><I><L><Q><S><F><S><R><F><T><R><V><P><S><G><G><Y><S><S><I><N><N><V><Q><D><P><Q><K><P><E><P><R><D><K><M><E><S><F><F><L><G><E><T><L><K><Y><L><F><L><L><F><S><D><D><P><N><L><L><S><L><D><A><Y><V><F><N><T><E><A><H><P><L><P><I><W><T><P><A>
Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2).<BOP>
Q9UKM7
Q5JU00
DRC5_HUMAN
T-complex-associated testis-expressed protein 1
Homo
<M><Q><D><T><V><T><T><S><A><L><L><D><P><S><H><S><S><V><S><T><Q><D><N><S><S><T><G><G><H><T><S><S><T><S><P><Q><L><S><K><P><S><I><T><P><V><P><A><K><S><R><N><P><H><P><R><A><N><I><R><R><M><R><R><I><I><A><E><D><P><E><W><S><L><A><I><V><P><L><L><T><E><L><C><I><Q><H><I><I><R><N><F><Q><K><N><P><I><L><K><Q><M><L><P><E><H><Q><Q><K><V><L><N><H><L><S><P><D><L><P><L><A><V><T><A><N><L><I><D><S><E><N><Y><W><L><R><C><C><M><H><R><W><P><V><C><H><V><A><H><H><G><G><S><W><K><R><M><F><F><E><R><H><L><E><N><L><L><K><H><F><I><P><G><T><T><D><P><A><V><I><L><D><L><L><P><L><C><R><N><Y><V><R><R><V><H><V><D><Q><F><L><P><P><V><Q><L><P><A><Q><L><R><P><G><D><Q><S><D><S><G><S><E><G><E><M><E><E><P><T><V><D><H><Y><Q><L><G><D><L><V><A><G><L><S><H><L><E><E><L><D><L><V><Y><D><V><K><D><C><G><M><N><F><E><W><N><L><F><L><F><T><Y><R><D><C><L><S><L><A><A><A><I><K><A><C><H><T><L><K><I><F><K><L><T><R><S><K><V><D><D><D><K><A><R><I><I><I><R><S><L><L><D><H><P><V><L><E><E><L><D><L><S><Q><N><L><I><G><D><R><G><A><R><G><A><A><K><L><L><S><H><S><R><L><R><V><L><N><L><A><N><N><Q><V><R><A><P><G><A><Q><S><L><A><H><A><L><A><H><N><T><N><L><I><S><L><N><L><R><L><N><C><I><E><D><E><G><G><Q><A><L><A><H><A><L><Q><T><N><K><C><L><T><T><L><H><L><G><G><N><E><L><S><E><P><T><A><T><L><L><S><Q><V><L><A><I><N><T><T><L><T><S><I><N><L><S><C><N><H><I><G><L><D><G><G><K><Q><L><L><E><G><M><S><D><N><K><T><L><L><E><F><D><L><R><L><S><D><V><A><Q><E><S><E><Y><L><I><G><Q><A><L><Y><A><N><R><E><A><A><R><Q><R><A><L><N><P><S><H><F><M><S><T><I><T><A><N><G><P><E><N><S><V><G>
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility.<BOP>
Q5JU00
P15976
GATA1_HUMAN
NF-E1 DNA-binding protein
Homo
<M><E><F><P><G><L><G><S><L><G><T><S><E><P><L><P><Q><F><V><D><P><A><L><V><S><S><T><P><E><S><G><V><F><F><P><S><G><P><E><G><L><D><A><A><A><S><S><T><A><P><S><T><A><T><A><A><A><A><A><L><A><Y><Y><R><D><A><E><A><Y><R><H><S><P><V><F><Q><V><Y><P><L><L><N><C><M><E><G><I><P><G><G><S><P><Y><A><G><W><A><Y><G><K><T><G><L><Y><P><A><S><T><V><C><P><T><R><E><D><S><P><P><Q><A><V><E><D><L><D><G><K><G><S><T><S><F><L><E><T><L><K><T><E><R><L><S><P><D><L><L><T><L><G><P><A><L><P><S><S><L><P><V><P><N><S><A><Y><G><G><P><D><F><S><S><T><F><F><S><P><T><G><S><P><L><N><S><A><A><Y><S><S><P><K><L><R><G><T><L><P><L><P><P><C><E><A><R><E><C><V><N><C><G><A><T><A><T><P><L><W><R><R><D><R><T><G><H><Y><L><C><N><A><C><G><L><Y><H><K><M><N><G><Q><N><R><P><L><I><R><P><K><K><R><L><I><V><S><K><R><A><G><T><Q><C><T><N><C><Q><T><T><T><T><T><L><W><R><R><N><A><S><G><D><P><V><C><N><A><C><G><L><Y><Y><K><L><H><Q><V><N><R><P><L><T><M><R><K><D><G><I><Q><T><R><N><R><K><A><S><G><K><G><K><K><K><R><G><S><S><L><G><G><T><G><A><A><E><G><P><A><G><G><F><M><V><V><A><G><G><S><G><S><G><N><C><G><E><V><A><S><G><L><T><L><G><P><P><G><T><A><H><L><Y><Q><G><L><G><P><V><V><L><S><G><P><V><S><H><L><M><P><F><P><G><P><L><L><G><S><P><T><G><S><F><P><T><G><P><M><P><P><T><T><S><T><T><V><V><A><P><L><S><S>
Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS .<BOP>
P15976
Q9HBU6
EKI1_HUMAN
Ethanolamine kinase 1
Homo
<M><L><C><G><R><P><R><S><S><S><D><N><R><N><F><L><R><E><R><A><G><L><S><S><A><A><V><Q><T><R><I><G><N><S><A><A><S><R><R><S><P><A><A><R><P><P><V><P><A><P><P><A><L><P><R><G><R><P><G><T><E><G><S><T><S><L><S><A><P><A><V><L><V><V><A><V><A><V><V><V><V><V><V><S><A><V><A><W><A><M><A><N><Y><I><H><V><P><P><G><S><P><E><V><P><K><L><N><V><T><V><Q><D><Q><E><E><H><R><C><R><E><G><A><L><S><L><L><Q><H><L><R><P><H><W><D><P><Q><E><V><T><L><Q><L><F><T><D><G><I><T><N><K><L><I><G><C><Y><V><G><N><T><M><E><D><V><V><L><V><R><I><Y><G><N><K><T><E><L><L><V><D><R><D><E><E><V><K><S><F><R><V><L><Q><A><H><G><C><A><P><Q><L><Y><C><T><F><N><N><G><L><C><Y><E><F><I><Q><G><E><A><L><D><P><K><H><V><C><N><P><A><I><F><R><L><I><A><R><Q><L><A><K><I><H><A><I><H><A><H><N><G><W><I><P><K><S><N><L><W><L><K><M><G><K><Y><F><S><L><I><P><T><G><F><A><D><E><D><I><N><K><R><F><L><S><D><I><P><S><S><Q><I><L><Q><E><E><M><T><W><M><K><E><I><L><S><N><L><G><S><P><V><V><L><C><H><N><D><L><L><C><K><N><I><I><Y><N><E><K><Q><G><D><V><Q><F><I><D><Y><E><Y><S><G><Y><N><Y><L><A><Y><D><I><G><N><H><F><N><E><F><A><G><V><S><D><V><D><Y><S><L><Y><P><D><R><E><L><Q><S><Q><W><L><R><A><Y><L><E><A><Y><K><E><F><K><G><F><G><T><E><V><T><E><K><E><V><E><I><L><F><I><Q><V><N><Q><F><A><L><A><S><H><F><F><W><G><L><W><A><L><I><Q><A><K><Y><S><T><I><E><F><D><F><L><G><Y><A><I><V><R><F><N><Q><Y><F><K><M><K><P><E><V><T><A><L><K><V><P><E>
Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.<BOP>
Q9HBU6
O96009
NAPSA_HUMAN
TA01/TA02
Homo
<M><S><P><P><P><L><L><Q><P><L><L><L><L><L><P><L><L><N><V><E><P><S><G><A><T><L><I><R><I><P><L><H><R><V><Q><P><G><R><R><I><L><N><L><L><R><G><W><R><E><P><A><E><L><P><K><L><G><A><P><S><P><G><D><K><P><I><F><V><P><L><S><N><Y><R><D><V><Q><Y><F><G><E><I><G><L><G><T><P><P><Q><N><F><T><V><A><F><D><T><G><S><S><N><L><W><V><P><S><R><R><C><H><F><F><S><V><P><C><W><L><H><H><R><F><D><P><K><A><S><S><S><F><Q><A><N><G><T><K><F><A><I><Q><Y><G><T><G><R><V><D><G><I><L><S><E><D><K><L><T><I><G><G><I><K><G><A><S><V><I><F><G><E><A><L><W><E><P><S><L><V><F><A><F><A><H><F><D><G><I><L><G><L><G><F><P><I><L><S><V><E><G><V><R><P><P><M><D><V><L><V><E><Q><G><L><L><D><K><P><V><F><S><F><Y><L><N><R><D><P><E><E><P><D><G><G><E><L><V><L><G><G><S><D><P><A><H><Y><I><P><P><L><T><F><V><P><V><T><V><P><A><Y><W><Q><I><H><M><E><R><V><K><V><G><P><G><L><T><L><C><A><K><G><C><A><A><I><L><D><T><G><T><S><L><I><T><G><P><T><E><E><I><R><A><L><H><A><A><I><G><G><I><P><L><L><A><G><E><Y><I><I><L><C><S><E><I><P><K><L><P><A><V><S><F><L><L><G><G><V><W><F><N><L><T><A><H><D><Y><V><I><Q><T><T><R><N><G><V><R><L><C><L><S><G><F><Q><A><L><D><V><P><P><P><A><G><P><F><W><I><L><G><D><V><F><L><G><T><Y><V><A><V><F><D><R><G><D><M><K><S><S><A><R><V><G><L><A><R><A><R><T><R><G><A><D><L><G><W><G><E><T><A><Q><A><Q><F><P><G>
May be involved in processing of pneumocyte surfactant precursors.<BOP>
O96009