accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1
value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q8NG84 | O2AK2_HUMAN | Olfactory receptor OR1-47 | Homo | <M><N><I><S><D><V><I><S><F><D><I><L><V><S><A><M><K><T><G><N><Q><S><F><G><T><D><F><L><L><V><G><L><F><Q><Y><G><W><I><N><S><L><L><F><V><V><I><A><T><L><F><T><V><A><L><T><G><N><I><M><L><I><H><L><I><R><L><N><T><R><L><H><T><P><M><Y><F><L><L><S><Q><L><S><I><V><D><L><M><Y><I><S><T><T><V><P><K><M><A><V><S><F><L><S><Q><S><K><T><I... | Odorant receptor.<BOP> | Q8NG84 |
Q15118 | PDK1_HUMAN | Pyruvate dehydrogenase kinase isoform 1 | Homo | <M><R><L><A><R><L><L><R><G><A><A><L><A><G><P><G><P><G><L><R><A><A><G><F><S><R><S><F><S><S><D><S><G><S><S><P><A><S><E><R><G><V><P><G><Q><V><D><F><Y><A><R><F><S><P><S><P><L><S><M><K><Q><F><L><D><F><G><S><V><N><A><C><E><K><T><S><F><M><F><L><R><Q><E><L><P><V><R><L><A><N><I><M><K><E><I><S><L><L><P><D><N><L><L><R><T><P><S><V... | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic re... | Q15118 |
Q96RJ0 | TAAR1_HUMAN | Trace amine-associated receptor 1 | Homo | <M><M><P><F><C><H><N><I><I><N><I><S><C><V><K><N><N><W><S><N><D><V><R><A><S><L><Y><S><L><M><V><L><I><I><L><T><T><L><V><G><N><L><I><V><I><V><S><I><S><H><F><K><Q><L><H><T><P><T><N><W><L><I><H><S><M><A><T><V><D><F><L><L><G><C><L><V><M><P><Y><S><M><V><R><S><A><E><H><C><W><Y><F><G><E><V><F><C><K><I><H><T><S><T><D><I><M><L><S... | Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic ami... | Q96RJ0 |
Q96NY8 | NECT4_HUMAN | Processed poliovirus receptor-related protein 4 | Homo | <M><P><L><S><L><G><A><E><M><W><G><P><E><A><W><L><L><L><L><L><L><L><A><S><F><T><G><R><C><P><A><G><E><L><E><T><S><D><V><V><T><V><V><L><G><Q><D><A><K><L><P><C><F><Y><R><G><D><S><G><E><Q><V><G><Q><V><A><W><A><R><V><D><A><G><E><G><A><Q><E><L><A><L><L><H><S><K><Y><G><L><H><V><S><P><A><Y><E><G><R><V><E><Q><P><P><P><P><R><N><P... | (Microbial infection) Acts as a receptor for measles virus.<BOP> | Q96NY8 |
Q13316 | DMP1_HUMAN | Dentin matrix acidic phosphoprotein 1 | Homo | <M><K><I><S><I><L><L><M><F><L><W><G><L><S><C><A><L><P><V><T><R><Y><Q><N><N><E><S><E><D><S><E><E><W><K><G><H><L><A><Q><A><P><T><P><P><L><E><S><S><E><S><S><E><G><S><K><V><S><S><E><E><Q><A><N><E><D><P><S><D><S><T><Q><S><E><E><G><L><G><S><D><D><H><Q><Y><I><Y><R><L><A><G><G><F><S><R><S><T><G><K><G><G><D><D><K><D><D><D><E><D... | May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into t... | Q13316 |
Q5TKA1 | LIN9_HUMAN | pRB-associated protein | Homo | <M><A><E><L><D><Q><L><P><D><E><S><S><S><A><K><A><L><V><S><L><K><E><G><S><L><S><N><T><W><N><E><K><Y><S><S><L><Q><K><T><P><V><W><K><G><R><N><T><S><S><A><V><E><M><P><F><R><N><S><K><R><S><R><L><F><S><D><E><D><D><R><Q><I><N><T><R><S><P><K><R><N><Q><R><V><A><M><V><P><Q><K><F><T><A><T><M><S><T><P><D><K><K><A><S><Q><K><I><G><F... | Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.<BOP> | Q5TKA1 |
Q8NHS3 | MFSD8_HUMAN | Ceroid-lipofuscinosis neuronal protein 7 | Homo | <M><A><G><L><R><N><E><S><E><Q><E><P><L><L><G><D><T><P><G><S><R><E><W><D><I><L><E><T><E><E><H><Y><K><S><R><W><R><S><I><R><I><L><Y><L><T><M><F><L><S><S><V><G><F><S><V><V><M><M><S><I><W><P><Y><L><Q><K><I><D><P><T><A><D><T><S><F><L><G><W><V><I><A><S><Y><S><L><G><Q><M><V><A><S><P><I><F><G><L><W><S><N><Y><R><P><R><K><E><P><L... | May be a carrier that transport small solutes by using chemiosmotic ion gradients.<BOP> | Q8NHS3 |
P23416 | GLRA2_HUMAN | Glycine receptor subunit alpha-2 | Homo | <M><N><R><Q><L><V><N><I><L><T><A><L><F><A><F><F><L><E><T><N><H><F><R><T><A><F><C><K><D><H><D><S><R><S><G><K><Q><P><S><Q><T><L><S><P><S><D><F><L><D><K><L><M><G><R><T><S><G><Y><D><A><R><I><R><P><N><F><K><G><P><P><V><N><V><T><C><N><I><F><I><N><S><F><G><S><V><T><E><T><T><M><D><Y><R><V><N><I><F><L><R><Q><Q><W><N><D><S><R><L... | Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine . Channel opening is also triggered by taurine and beta-alanine . Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents . Plays a role in ... | P23416 |
O95563 | MPC2_HUMAN | Brain protein 44 | Homo | <M><S><A><A><G><A><R><G><L><R><A><T><Y><H><R><L><L><D><K><V><E><L><M><L><P><E><K><L><R><P><L><Y><N><H><P><A><G><P><R><T><V><F><F><W><A><P><I><M><K><W><G><L><V><C><A><G><L><A><D><M><A><R><P><A><E><K><L><S><T><A><Q><S><A><V><L><M><A><T><G><F><I><W><S><R><Y><S><L><V><I><I><P><K><N><W><S><L><F><A><V><N><F><F><V><G><A><A><G... | Mediates the uptake of pyruvate into mitochondria.<BOP> | O95563 |
P17706 | PTN2_HUMAN | T-cell protein-tyrosine phosphatase | Homo | <M><P><T><T><I><E><R><E><F><E><E><L><D><T><Q><R><R><W><Q><P><L><Y><L><E><I><R><N><E><S><H><D><Y><P><H><R><V><A><K><F><P><E><N><R><N><R><N><R><Y><R><D><V><S><P><Y><D><H><S><R><V><K><L><Q><N><A><E><N><D><Y><I><N><A><S><L><V><D><I><E><E><A><Q><R><S><Y><I><L><T><Q><G><P><L><P><N><T><C><C><H><F><W><L><M><V><W><Q><Q><K><T><K... | Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively reg... | P17706 |
Q15051 | IQCB1_HUMAN | p53 and DNA damage-regulated IQ motif protein | Homo | <M><K><P><T><G><T><D><P><R><I><L><S><I><A><A><E><V><A><K><S><P><E><Q><N><V><P><V><I><L><L><K><L><K><E><I><I><N><I><T><P><L><G><S><S><E><L><K><K><I><K><Q><D><I><Y><C><Y><D><L><I><Q><Y><C><L><L><V><L><S><Q><D><Y><S><R><I><Q><G><G><W><T><T><I><S><Q><L><T><Q><I><L><S><H><C><C><V><G><L><E><P><G><E><D><A><E><E><F><Y><N><E><L... | Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 . Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling ... | Q15051 |
Q8NGK3 | O52K2_HUMAN | Olfactory receptor OR11-7 | Homo | <M><S><A><S><N><I><T><L><T><H><P><T><A><F><L><L><V><G><I><P><G><L><E><H><L><H><I><W><I><S><I><P><F><C><L><A><Y><T><L><A><L><L><G><N><C><T><L><L><L><I><I><Q><A><D><A><A><L><H><E><P><M><Y><L><F><L><A><M><L><A><A><I><D><L><V><L><S><S><S><A><L><P><K><M><L><A><I><F><W><F><R><D><R><E><I><N><F><F><A><C><L><A><Q><M><F><F><L><H... | Odorant receptor.<BOP> | Q8NGK3 |
P05362 | ICAM1_HUMAN | Major group rhinovirus receptor | Homo | <M><A><P><S><S><P><R><P><A><L><P><A><L><L><V><L><L><G><A><L><F><P><G><P><G><N><A><Q><T><S><V><S><P><S><K><V><I><L><P><R><G><G><S><V><L><V><T><C><S><T><S><C><D><Q><P><K><L><L><G><I><E><T><P><L><P><K><K><E><L><L><L><P><G><N><N><R><K><V><Y><E><L><S><N><V><Q><E><D><S><Q><P><M><C><Y><S><N><C><P><D><G><Q><S><T><A><K><T><F><L... | (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.<BOP> | P05362 |
P06280 | AGAL_HUMAN | Melibiase | Homo | <M><Q><L><R><N><P><E><L><H><L><G><C><A><L><A><L><R><F><L><A><L><V><S><W><D><I><P><G><A><R><A><L><D><N><G><L><A><R><T><P><T><M><G><W><L><H><W><E><R><F><M><C><N><L><D><C><Q><E><E><P><D><S><C><I><S><E><K><L><F><M><E><M><A><E><L><M><V><S><E><G><W><K><D><A><G><Y><E><Y><L><C><I><D><D><C><W><M><A><P><Q><R><D><S><E><G><R><L><Q... | Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.<BOP> | P06280 |
Q9UQF2 | JIP1_HUMAN | Mitogen-activated protein kinase 8-interacting protein 1 | Homo | <M><A><E><R><E><S><G><G><L><G><G><G><A><A><S><P><P><A><A><S><P><F><L><G><L><H><I><A><S><P><P><N><F><R><L><T><H><D><I><S><L><E><E><F><E><D><E><D><L><S><E><I><T><D><E><C><G><I><S><L><Q><C><K><D><T><L><S><L><R><P><P><R><A><G><L><L><S><A><G><G><G><G><A><G><S><R><L><Q><A><E><M><L><Q><M><D><L><I><D><A><T><G><D><T><P><G><A><E... | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activit... | Q9UQF2 |
Q9Y2V7 | COG6_HUMAN | Component of oligomeric Golgi complex 6 | Homo | <M><A><E><G><S><G><E><V><V><A><V><S><A><T><G><A><A><N><G><L><N><N><G><A><G><G><T><S><A><T><T><C><N><P><L><S><R><K><L><H><K><I><L><E><T><R><L><D><N><D><K><E><M><L><E><A><L><K><A><L><S><T><F><F><V><E><N><S><L><R><T><R><R><N><L><R><G><D><I><E><R><K><S><L><A><I><N><E><E><F><V><S><I><F><K><E><V><K><E><E><L><E><S><I><S><E><D... | Required for normal Golgi function.<BOP> | Q9Y2V7 |
P0DPK2 | H3Y1_HUMAN | Histone H3.Y1 | Homo | <M><A><R><T><K><Q><T><A><R><K><A><T><A><W><Q><A><P><R><K><P><L><A><T><K><A><A><G><K><R><A><P><P><T><G><G><I><K><K><P><H><R><Y><K><P><G><T><L><A><L><R><E><I><R><K><Y><Q><K><S><T><Q><L><L><L><R><K><L><P><F><Q><R><L><V><R><E><I><A><Q><A><I><S><P><D><L><R><F><Q><S><A><A><I><G><A><L><Q><E><A><S><E><A><Y><L><V><Q><L><F><E><D... | Primate-specific variant histone H3, which constitutes a core component of nucleosomes . Histone H3.Y-containing nucleosomes accumulate around transcription start sites and have flexible DNA ends, suggesting that they form relaxed chromatin that allows transcription factor access . Histone H1 binds less efficiently to ... | P0DPK2 |
Q96BR5 | COA7_HUMAN | Sel1 repeat-containing protein 1 | Homo | <M><A><G><M><V><D><F><Q><D><E><E><Q><V><K><S><F><L><E><N><M><E><V><E><C><N><Y><H><C><Y><H><E><K><D><P><D><G><C><Y><R><L><V><D><Y><L><E><G><I><R><K><N><F><D><E><A><A><K><V><L><K><F><N><C><E><E><N><Q><H><S><D><S><C><Y><K><L><G><A><Y><Y><V><T><G><K><G><G><L><T><Q><D><L><K><A><A><A><R><C><F><L><M><A><C><E><K><P><G><K><K><S... | Required for assembly of mitochondrial respiratory chain complex I and complex IV.<BOP> | Q96BR5 |
Q9UBD5 | ORC3_HUMAN | Origin recognition complex subunit Latheo | Homo | <M><A><T><S><S><M><S><K><G><C><F><V><F><K><P><N><S><K><K><R><K><I><S><L><P><I><E><D><Y><F><N><K><G><K><N><E><P><E><D><S><K><L><R><F><E><T><Y><Q><L><I><W><Q><Q><M><K><S><E><N><E><R><L><Q><E><E><L><N><K><N><L><F><D><N><L><I><E><F><L><Q><K><S><H><S><G><F><Q><K><N><S><R><D><L><G><G><Q><I><K><L><R><E><I><P><T><A><A><L><V><L... | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 a... | Q9UBD5 |
Q8NHP8 | PLBL2_HUMAN | Putative phospholipase B-like 2 45 kDa form | Homo | <M><V><G><Q><M><Y><C><Y><P><G><S><H><L><A><R><A><L><T><R><A><L><A><L><A><L><V><L><A><L><L><V><G><P><F><L><S><G><L><A><G><A><I><P><A><P><G><G><R><W><A><R><D><G><Q><V><P><P><A><S><R><S><R><S><V><L><L><D><V><S><A><G><Q><L><L><M><V><D><G><R><H><P><D><A><V><A><W><A><N><L><T><N><A><I><R><E><T><G><W><A><F><L><E><L><G><T><S><G... | Putative phospholipase.<BOP> | Q8NHP8 |
Q16851 | UGPA_HUMAN | UDP-glucose pyrophosphorylase | Homo | <M><S><R><F><V><Q><D><L><S><K><A><M><S><Q><D><G><A><S><Q><F><Q><E><V><I><R><Q><E><L><E><L><S><V><K><K><E><L><E><K><I><L><T><T><A><S><S><H><E><F><E><H><T><K><K><D><L><D><G><F><R><K><L><F><H><R><F><L><Q><E><K><G><P><S><V><D><W><G><K><I><Q><R><P><P><E><D><S><I><Q><P><Y><E><K><I><K><A><R><G><L><P><D><N><I><S><S><V><L><N><K... | UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.<BOP> | Q16851 |
P0DTW3 | HV384_HUMAN | Probable non-functional immunoglobulin heavy variable 1-38-4 | Homo | <M><D><W><N><W><R><I><L><F><L><V><V><A><T><T><G><A><H><S><Q><V><Q><L><V><Q><S><W><A><E><V><R><K><S><G><A><S><V><K><V><S><C><S><F><S><G><F><T><I><T><S><Y><G><I><H><W><V><Q><Q><S><P><G><Q><G><L><E><W><M><G><W><I><N><P><G><N><G><S><P><S><Y><A><K><K><F><Q><G><R><F><T><M><T><R><D><M><S><T><T><T><A><Y><T><D><L><S><S><L><T><S... | Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains . Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved ... | P0DTW3 |
Q9H0M5 | ZN700_HUMAN | Zinc finger protein 700 | Homo | <M><P><C><C><S><H><R><S><C><R><E><D><P><G><T><S><E><S><R><E><M><D><P><V><A><F><E><D><V><A><V><N><F><T><Q><E><E><W><T><L><L><D><I><S><Q><K><N><L><F><R><E><V><M><L><E><T><F><R><N><L><T><S><I><G><K><K><W><S><D><Q><N><I><E><Y><E><Y><Q><N><P><R><R><S><F><R><S><L><I><E><E><K><V><N><E><I><K><E><D><S><H><C><G><E><T><F><T><Q><V... | May be involved in transcriptional regulation.<BOP> | Q9H0M5 |
Q8NHY0 | B4GN2_HUMAN | UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase | Homo | <M><G><S><A><G><F><S><V><G><K><F><H><V><E><V><A><S><R><G><R><E><C><V><S><G><T><P><E><C><G><N><R><L><G><S><A><G><F><G><A><L><C><L><E><L><R><G><A><D><P><A><W><G><P><F><A><A><H><G><R><S><R><R><Q><G><S><R><F><L><W><L><L><K><I><L><V><I><I><L><V><L><G><I><V><G><F><M><F><G><S><M><F><L><Q><A><V><F><S><S><P><K><P><E><L><P><S><P... | Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain.<BOP> | Q8NHY0 |
P09669 | COX6C_HUMAN | Cytochrome c oxidase polypeptide VIc | Homo | <M><A><P><E><V><L><P><K><P><R><M><R><G><L><L><A><R><R><L><R><N><H><M><A><V><A><F><V><L><S><L><G><V><A><A><L><Y><K><F><R><V><A><D><Q><R><K><K><A><Y><A><D><F><Y><R><N><Y><D><V><M><K><D><F><E><E><M><R><K><A><G><I><F><Q><S><V><K> | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CII... | P09669 |
Q8IYB4 | PEX5R_HUMAN | Tetratricopeptide repeat-containing Rab8b-interacting protein | Homo | <M><Y><Q><G><H><M><Q><K><S><K><E><Q><G><Y><G><K><L><S><S><D><E><D><L><E><I><I><V><D><Q><K><Q><G><K><G><S><R><A><A><D><K><A><V><A><M><V><M><K><E><I><P><R><E><E><S><A><E><E><K><P><L><L><T><M><T><S><Q><L><V><N><E><Q><Q><E><S><R><P><L><L><S><P><S><I><D><D><F><L><C><E><T><K><S><E><A><I><A><R><P><V><T><S><N><T><A><V><L><T><T... | Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.<BOP> | Q8IYB4 |
Q9Y248 | PSF2_HUMAN | GINS complex subunit 2 | Homo | <M><D><A><A><E><V><E><F><L><A><E><K><E><L><V><T><I><I><P><N><F><S><L><D><K><I><Y><L><I><G><G><D><L><G><P><F><N><P><G><L><P><V><E><V><P><L><W><L><A><I><N><L><K><Q><R><Q><K><C><R><L><L><P><P><E><W><M><D><V><E><K><L><E><K><M><R><D><H><E><R><K><E><E><T><F><T><P><M><P><S><P><Y><Y><M><E><L><T><K><L><L><L><N><H><A><S><D><N><I... | Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks . GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around ... | Q9Y248 |
Q9Y5A7 | NUB1_HUMAN | Renal carcinoma antigen NY-REN-18 | Homo | <M><A><Q><K><K><Y><L><Q><A><K><L><T><Q><F><L><R><E><D><R><I><Q><L><W><K><P><P><Y><T><D><E><N><K><K><V><G><L><A><L><K><D><L><A><K><Q><Y><S><D><R><L><E><C><C><E><N><E><V><E><K><V><I><E><E><I><R><C><K><A><I><E><R><G><T><G><N><D><N><Y><R><T><T><G><I><A><T><I><E><V><F><L><P><P><R><L><K><K><D><R><K><N><L><L><E><T><R><L><H><I... | Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.<BOP> | Q9Y5A7 |
O76076 | CCN5_HUMAN | WNT1-inducible-signaling pathway protein 2 | Homo | <M><R><G><T><P><K><T><H><L><L><A><F><S><L><L><C><L><L><S><K><V><R><T><Q><L><C><P><T><P><C><T><C><P><W><P><P><P><R><C><P><L><G><V><P><L><V><L><D><G><C><G><C><C><R><V><C><A><R><R><L><G><E><P><C><D><Q><L><H><V><C><D><A><S><Q><G><L><V><C><Q><P><G><A><G><P><G><G><R><G><A><L><C><L><L><A><E><D><D><S><S><C><E><V><N><G><R><L><Y... | May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.<BOP> | O76076 |
Q9Y421 | FA32A_HUMAN | Ovarian tumor-associated gene 12 | Homo | <M><E><A><Y><E><Q><V><Q><K><G><P><L><K><L><K><G><V><A><E><L><G><V><T><K><R><K><K><K><K><K><D><K><D><K><A><K><L><L><E><A><M><G><T><S><K><K><N><E><E><E><K><R><R><G><L><D><K><R><T><P><A><Q><A><A><F><E><K><M><Q><E><K><R><Q><M><E><R><I><L><K><K><A><S><K><T><H><K><Q><R><V><E><D><F><N><R><H><L><D><T><L><T><E><H><Y><D><I><P><K... | Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.<BOP> | Q9Y421 |
P78415 | IRX3_HUMAN | Iroquois homeobox protein 3 | Homo | <M><S><F><P><Q><L><G><Y><Q><Y><I><R><P><L><Y><P><S><E><R><P><G><A><A><G><G><S><G><G><S><A><G><A><R><G><G><L><G><A><G><A><S><E><L><N><A><S><G><S><L><S><N><V><L><S><S><V><Y><G><A><P><Y><A><A><A><A><A><A><A><A><A><Q><G><Y><G><A><F><L><P><Y><A><A><E><L><P><I><F><P><Q><L><G><A><Q><Y><E><L><K><D><S><P><G><V><Q><H><P><A><A><A... | Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcripti... | P78415 |
Q8IVG9 | HUNIN_HUMAN | Humanin mitochondrial | Homo | <M><A><P><R><G><F><S><C><L><L><L><L><T><S><E><I><D><L><P><V><K><R><R><A> | Plays a role as a neuroprotective factor . Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease . Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR . Also... | Q8IVG9 |
P24468 | COT2_HUMAN | Nuclear receptor subfamily 2 group F member 2 | Homo | <M><A><M><V><V><S><T><W><R><D><P><Q><D><E><V><P><G><S><Q><G><S><Q><A><S><Q><A><P><P><V><P><G><P><P><P><G><A><P><H><T><P><Q><T><P><G><Q><G><G><P><A><S><T><P><A><Q><T><A><A><G><G><Q><G><G><P><G><G><P><G><S><D><K><Q><Q><Q><Q><Q><H><I><E><C><V><V><C><G><D><K><S><S><G><K><H><Y><G><Q><F><T><C><E><G><C><K><S><F><F><K><R><S><V... | Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during earl... | P24468 |
Q6ZVM7 | TM1L2_HUMAN | Target of Myb-like protein 2 | Homo | <M><E><F><L><L><G><N><P><F><S><T><P><V><G><Q><C><L><E><K><A><T><D><G><S><L><Q><S><E><D><W><T><L><N><M><E><I><C><D><I><I><N><E><T><E><E><G><P><K><D><A><I><R><A><L><K><K><R><L><N><G><N><R><N><Y><R><E><V><M><L><A><L><T><V><L><E><T><C><V><K><N><C><G><H><R><F><H><I><L><V><A><N><R><D><F><I><D><S><V><L><V><K><I><I><S><P><K><N... | Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures . May also play a role in recruiting clathrin to endosomes . May regulate growth factor-induced mitogenic signaling .<BOP> | Q6ZVM7 |
O43309 | ZSC12_HUMAN | Zinc finger protein 96 | Homo | <M><A><S><T><W><A><I><Q><A><H><M><D><Q><D><E><P><L><E><V><K><I><E><E><E><K><Y><T><T><R><Q><D><W><D><L><R><K><N><N><T><H><S><R><E><V><F><R><Q><Y><F><R><Q><F><C><Y><Q><E><T><S><G><P><R><E><A><L><S><R><L><R><E><L><C><H><Q><W><L><R><P><E><T><H><T><K><E><Q><I><L><E><L><L><V><L><E><Q><F><L><T><I><L><P><E><E><L><Q><A><W><V><Q... | May be involved in transcriptional regulation.<BOP> | O43309 |
Q5T6S3 | PHF19_HUMAN | Polycomb-like protein 3 | Homo | <M><E><N><R><A><L><D><P><G><T><R><D><S><Y><G><A><T><S><H><L><P><N><K><G><A><L><A><K><V><K><N><N><F><K><D><L><M><S><K><L><T><E><G><Q><Y><V><L><C><R><W><T><D><G><L><Y><Y><L><G><K><I><K><R><V><S><S><S><K><Q><S><C><L><V><T><F><E><D><N><S><K><Y><W><V><L><W><K><D><I><Q><H><A><G><V><P><G><E><E><P><K><C><N><I><C><L><G><K><T><S... | Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity . Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a ma... | Q5T6S3 |
P63121 | VP113_HUMAN | Proteinase | Homo | <W><A><S><Q><V><S><E><N><R><P><V><C><K><A><I><I><Q><G><K><Q><F><E><G><L><V><D><T><G><A><D><V><S><I><I><A><L><N><Q><W><P><K><N><W><P><K><Q><K><A><V><T><G><L><V><G><I><S><T><A><S><E><V><Y><Q><S><T><E><I><L><H><C><L><G><P><D><N><Q><E><S><T><V><Q><P><M><I><T><S><I><P><L><N><L><W><G><R><D><L><L><Q><Q><W><G><V><E><I><T><M><P... | Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.<BOP> | P63121 |
P09630 | HXC6_HUMAN | Homeobox protein Hox-3C | Homo | <M><N><S><Y><F><T><N><P><S><L><S><C><H><L><A><G><G><Q><D><V><L><P><N><V><A><L><N><S><T><A><Y><D><P><V><R><H><F><S><T><Y><G><A><A><V><A><Q><N><R><I><Y><S><T><P><F><Y><S><P><Q><E><N><V><V><F><S><S><S><R><G><P><Y><D><Y><G><S><N><S><F><Y><Q><E><K><D><M><L><S><N><C><R><Q><N><T><L><G><H><N><T><Q><T><S><I><A><Q><D><F><S><S><E... | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP> | P09630 |
Q9Y282 | ERGI3_HUMAN | Serologically defined breast cancer antigen NY-BR-84 | Homo | <M><E><A><L><G><K><L><K><Q><F><D><A><Y><P><K><T><L><E><D><F><R><V><K><T><C><G><G><A><T><V><T><I><V><S><G><L><L><M><L><L><L><F><L><S><E><L><Q><Y><Y><L><T><T><E><V><H><P><E><L><Y><V><D><K><S><R><G><D><K><L><K><I><N><I><D><V><L><F><P><H><M><P><C><A><Y><L><S><I><D><A><M><D><V><A><G><E><Q><Q><L><D><V><E><H><N><L><F><K><Q><R... | Possible role in transport between endoplasmic reticulum and Golgi. Positively regulates trafficking of the secretory proteins SERPINA1/alpha1-antitrypsin and HP/haptoglobin .<BOP> | Q9Y282 |
Q12912 | IRAG2_HUMAN | Processed inositol 1,4,5-triphosphate receptor associated 2 | Homo | <M><E><S><T><P><F><S><G><V><A><N><Q><I><H><T><L><C><E><R><P><T><Y><G><E><V><K><D><G><A><L><D><V><K><R><Q><H><K><C><P><G><P><T><S><G><P><S><P><G><T><N><L><S><G><C><I><R><M><N><D><D><P><S><M><E><E><N><G><V><E><R><V><C><P><E><S><L><L><Q><S><R><E><Y><S><S><L><P><L><P><R><H><T><S><S><T><D><G><T><I><T><S><S><D><P><G><L><E><I... | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusio... | Q12912 |
Q15067 | ACOX1_HUMAN | Peroxisomal acyl-CoA oxidase 1, C chain | Homo | <M><N><P><D><L><R><R><E><R><D><S><A><S><F><N><P><E><L><L><T><H><I><L><D><G><S><P><E><K><T><R><R><R><R><E><I><E><N><M><I><L><N><D><P><D><F><Q><H><E><D><L><N><F><L><T><R><S><Q><R><Y><E><V><A><V><R><K><S><A><I><M><V><K><K><M><R><E><F><G><I><A><D><P><D><E><I><M><W><F><K><K><L><H><L><V><N><F><V><E><P><V><G><L><N><Y><S><M><F... | Is active against a much broader range of substrates and shows activity towards long-chain fatty acyl-CoAs.<BOP> | Q15067 |
Q9UBK5 | HCST_HUMAN | Transmembrane adapter protein KAP10 | Homo | <M><I><H><L><G><H><I><L><F><L><L><L><L><P><V><A><A><A><Q><T><T><P><G><E><R><S><S><L><P><A><F><Y><P><G><T><S><G><S><C><S><G><C><G><S><L><S><L><P><L><L><A><G><L><V><A><A><D><A><V><A><S><L><L><I><V><G><A><V><F><L><C><A><R><P><R><R><S><P><A><Q><E><D><G><K><V><Y><I><N><M><P><G><R><G> | Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (... | Q9UBK5 |
Q9Y463 | DYR1B_HUMAN | Mirk protein kinase | Homo | <M><A><V><P><P><G><H><G><P><F><S><G><F><P><G><P><Q><E><H><T><Q><V><L><P><D><V><R><L><L><P><R><R><L><P><L><A><F><R><D><A><T><S><A><P><L><R><K><L><S><V><D><L><I><K><T><Y><K><H><I><N><E><V><Y><Y><A><K><K><K><R><R><A><Q><Q><A><P><P><Q><D><S><S><N><K><K><E><K><K><V><L><N><H><G><Y><D><D><D><N><H><D><Y><I><V><R><S><G><E><R><W... | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance . During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of th... | Q9Y463 |
Q4G0A6 | MINY4_HUMAN | Probable deubiquitinating enzyme MINDY-4 | Homo | <M><D><S><L><F><V><E><E><V><A><A><S><L><V><R><E><F><L><S><R><K><G><L><K><K><T><C><V><T><M><D><Q><E><R><P><R><S><D><L><S><I><N><N><R><N><D><L><R><K><V><L><H><L><E><F><L><Y><K><E><N><K><A><K><E><N><P><L><K><T><S><L><E><L><I><T><R><Y><F><L><D><H><F><G><N><T><A><N><N><F><T><Q><D><T><P><I><P><A><L><S><V><P><K><K><N><N><K><V... | Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.<BOP> | Q4G0A6 |
O75414 | NDK6_HUMAN | nm23-H6 | Homo | <M><A><S><I><L><R><S><P><Q><A><L><Q><L><T><L><A><L><I><K><P><D><A><V><A><H><P><L><I><L><E><A><V><H><Q><Q><I><L><S><N><K><F><L><I><V><R><M><R><E><L><L><W><R><K><E><D><C><Q><R><F><Y><R><E><H><E><G><R><F><F><Y><Q><R><L><V><E><F><M><A><S><G><P><I><R><A><Y><I><L><A><H><K><D><A><I><Q><L><W><R><T><L><M><G><P><T><R><V><F><R><A... | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.<BOP> | O75414 |
Q8NH09 | OR8S1_HUMAN | Olfactory receptor 8S1 | Homo | <M><A><L><G><N><H><S><T><I><T><E><F><L><L><L><G><L><S><A><D><P><N><I><R><A><L><L><F><V><L><F><L><G><I><Y><L><L><T><I><M><E><N><L><M><L><L><L><M><I><R><A><D><S><C><L><H><K><P><M><Y><F><F><L><S><H><L><S><F><V><D><L><C><F><S><S><V><I><V><P><K><M><L><E><N><L><L><S><Q><R><K><T><I><S><V><E><G><C><L><A><Q><V><F><F><V><F><V><T... | Odorant receptor.<BOP> | Q8NH09 |
Q96S37 | S22AC_HUMAN | Urate:anion antiporter SLC22A12 | Homo | <M><A><F><S><E><L><L><D><L><V><G><G><L><G><R><F><Q><V><L><Q><T><M><A><L><M><V><S><I><M><W><L><C><T><Q><S><M><L><E><N><F><S><A><A><V><P><S><H><R><C><W><A><P><L><L><D><N><S><T><A><Q><A><S><I><L><G><S><L><S><P><E><A><L><L><A><I><S><I><P><P><G><P><N><Q><R><P><H><Q><C><R><R><F><R><Q><P><Q><W><Q><L><L><D><P><N><A><T><A><T><S... | Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions . Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid . Mediates urate uptake by an exchange with organic anions such as (S)-l... | Q96S37 |
Q9Y330 | ZBT12_HUMAN | Protein G10 | Homo | <M><A><S><G><V><E><V><L><R><F><Q><L><P><G><H><E><A><A><T><L><R><N><M><N><Q><L><R><A><E><E><R><F><C><D><V><T><I><V><A><D><S><L><K><F><R><G><H><K><V><I><L><A><A><C><S><P><F><L><R><D><Q><F><L><L><N><P><S><S><E><L><Q><V><S><L><M><H><S><A><R><I><V><A><D><L><L><L><S><C><Y><T><G><A><L><E><F><A><V><R><D><I><V><N><Y><L><T><A><A... | May be involved in transcriptional regulation.<BOP> | Q9Y330 |
Q5T7M4 | ADIPL_HUMAN | Adipolin gCTRP12 | Homo | <M><R><R><W><A><W><A><A><V><V><V><L><L><G><P><Q><L><V><L><L><G><G><V><G><A><R><R><E><A><Q><R><T><Q><Q><P><G><Q><R><A><D><P><P><N><A><T><A><S><A><S><S><R><E><G><L><P><E><A><P><K><P><S><Q><A><S><G><P><E><F><S><D><A><H><M><T><W><L><N><F><V><R><R><P><D><D><G><A><L><R><K><R><C><G><S><R><D><K><K><P><R><D><L><F><G><P><P><G><P... | Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuat... | Q5T7M4 |
P51508 | ZNF81_HUMAN | HFZ20 | Homo | <M><P><A><N><E><D><A><P><Q><P><G><E><H><G><S><A><C><E><V><S><V><S><F><E><D><V><T><V><D><F><S><R><E><E><W><Q><Q><L><D><S><T><Q><R><R><L><Y><Q><D><V><M><L><E><N><Y><S><H><L><L><S><V><G><F><E><V><P><K><P><E><V><I><F><K><L><E><Q><G><E><G><P><W><T><L><E><G><E><A><P><H><Q><S><C><S><D><G><K><F><G><I><K><P><S><Q><R><R><I><S><G... | May be involved in transcriptional regulation.<BOP> | P51508 |
Q8IX05 | CD302_HUMAN | Type I transmembrane C-type lectin receptor DCL-1 | Homo | <M><L><R><A><A><L><P><A><L><L><L><P><L><L><G><L><A><A><A><A><V><A><D><C><P><S><S><T><W><I><Q><F><Q><D><S><C><Y><I><F><L><Q><E><A><I><K><V><E><S><I><E><D><V><R><N><Q><C><T><D><H><G><A><D><M><I><S><I><H><N><E><E><E><N><A><F><I><L><D><T><L><K><K><Q><W><K><G><P><D><D><I><L><L><G><M><F><Y><D><T><D><D><A><S><F><K><W><F><D><N... | Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.<BOP> | Q8IX05 |
Q8N414 | PGBD5_HUMAN | PiggyBac transposase 5 | Homo | <M><A><E><G><G><G><G><A><R><R><R><A><P><A><L><L><E><A><A><R><A><R><Y><E><S><L><H><I><S><D><D><V><F><G><E><S><G><P><D><S><G><G><N><P><F><Y><S><T><S><A><A><S><R><S><S><S><A><A><S><S><D><D><E><R><E><P><P><G><P><P><G><A><A><P><P><P><P><R><A><P><D><A><Q><E><P><E><E><D><E><A><G><A><G><W><S><A><A><L><R><D><R><P><P><P><R><F><E... | Transposase that mediates sequence-specific genomic rearrangements . Can induce genomic rearrangements that inactivate the HPRT1 gene .<BOP> | Q8N414 |
Q8IUC3 | KRA71_HUMAN | High tyrosine-glycine keratin-associated protein 7.1 | Homo | <M><T><R><Y><F><C><C><G><S><Y><F><P><G><Y><P><I><Y><G><T><N><F><H><G><T><F><R><A><T><P><L><N><C><V><V><P><L><G><S><P><L><N><Y><G><C><G><C><N><G><Y><S><S><L><G><Y><S><F><G><G><S><N><I><N><N><L><G><G><C><Y><G><G><S><F><Y><R><P><W><G><S><G><S><G><F><G><Y><S><T><Y> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of ha... | Q8IUC3 |
Q8NET6 | CHSTD_HUMAN | Chondroitin 4-sulfotransferase 3 | Homo | <M><G><R><R><C><C><R><R><R><V><L><A><A><A><C><L><G><A><A><L><L><L><L><C><A><A><P><R><S><L><R><P><A><F><G><N><R><A><L><G><S><S><W><L><G><G><E><K><R><S><P><L><Q><K><L><Y><D><L><D><Q><D><P><R><S><T><L><A><K><V><H><R><Q><R><R><D><L><L><N><S><A><C><S><R><H><S><R><R><Q><R><L><L><Q><P><E><D><L><R><H><V><L><V><D><D><A><H><G><L... | Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-lin... | Q8NET6 |
P57768 | SNX16_HUMAN | Sorting nexin-16 | Homo | <M><A><T><P><Y><V><P><V><P><M><P><I><G><N><S><A><S><S><F><T><T><N><R><N><Q><R><S><S><S><F><G><S><V><S><T><S><S><N><S><S><K><G><Q><L><E><D><S><N><M><G><N><F><K><Q><T><S><V><P><D><Q><M><D><N><T><S><S><V><C><S><S><P><L><I><R><T><K><F><T><G><T><A><S><S><I><E><Y><S><T><R><P><R><D><T><E><E><Q><N><P><E><T><V><N><W><E><D><R><P... | May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from th... | P57768 |
Q9NVR2 | INT10_HUMAN | Integrator complex subunit 10 | Homo | <M><S><A><Q><G><D><C><E><F><L><V><Q><R><A><R><E><L><V><P><Q><D><L><W><A><A><K><A><W><L><I><T><A><R><S><L><Y><P><A><D><F><N><I><Q><Y><E><M><Y><T><I><E><R><N><A><E><R><T><A><T><A><G><R><L><L><Y><D><M><F><V><N><F><P><D><Q><P><V><V><W><R><E><I><S><I><I><T><S><A><L><R><N><D><S><Q><D><K><Q><T><Q><F><L><R><S><L><F><E><T><L><P... | Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs g... | Q9NVR2 |
Q14353 | GAMT_HUMAN | Guanidinoacetate N-methyltransferase | Homo | <M><S><A><P><S><A><T><P><I><F><A><P><G><E><N><C><S><P><A><W><G><A><A><P><A><A><Y><D><A><A><D><T><H><L><R><I><L><G><K><P><V><M><E><R><W><E><T><P><Y><M><H><A><L><A><A><A><A><S><S><K><G><G><R><V><L><E><V><G><F><G><M><A><I><A><A><S><K><V><Q><E><A><P><I><D><E><H><W><I><I><E><C><N><D><G><V><F><Q><R><L><R><D><W><A><P><R><Q><T... | Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor . Important in nervous system development .<BOP> | Q14353 |
P0DN82 | O12D1_HUMAN | Olfactory receptor 12D1 | Homo | <M><L><N><T><T><S><V><T><E><F><L><L><L><G><V><T><D><I><Q><E><L><Q><P><F><L><F><V><V><F><L><T><I><Y><F><I><S><V><A><G><N><G><A><I><L><M><I><V><I><S><D><P><R><L><H><S><P><M><Y><F><F><L><G><N><L><S><C><L><D><I><C><Y><S><S><V><T><L><P><K><M><L><Q><N><F><L><S><A><H><K><A><I><S><F><L><G><C><I><S><Q><L><H><F><F><H><F><L><G><S... | Odorant receptor.<BOP> | P0DN82 |
Q92911 | SC5A5_HUMAN | Solute carrier family 5 member 5 | Homo | <M><E><A><V><E><T><G><E><R><P><T><F><G><A><W><D><Y><G><V><F><A><L><M><L><L><V><S><T><G><I><G><L><W><V><G><L><A><R><G><G><Q><R><S><A><E><D><F><F><T><G><G><R><R><L><A><A><L><P><V><G><L><S><L><S><A><S><F><M><S><A><V><Q><V><L><G><V><P><S><E><A><Y><R><Y><G><L><K><F><L><W><M><C><L><G><Q><L><L><N><S><V><L><T><A><L><L><F><M><P... | Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland . Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate .<BOP> | Q92911 |
P0DTE5 | UD2A2_HUMAN | UDP-glucuronosyltransferase 2A2 | Homo | <M><V><S><I><R><D><F><T><M><P><K><K><F><V><Q><M><L><V><F><N><L><T><L><T><E><V><V><L><S><G><N><V><L><I><W><P><T><D><G><S><H><W><L><N><I><K><I><I><L><E><E><L><I><Q><R><N><H><N><V><T><V><L><A><S><S><A><T><L><F><I><N><S><N><P><D><S><P><V><N><F><E><V><I><P><V><S><Y><K><K><S><N><I><D><S><L><I><E><H><M><I><M><L><W><I><D><H><R... | UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile . Essential for the elimination and detoxification of drugs... | P0DTE5 |
P01562 | IFNA1_HUMAN | Interferon alpha-D | Homo | <M><A><S><P><F><A><L><L><M><V><L><V><V><L><S><C><K><S><S><C><S><L><G><C><D><L><P><E><T><H><S><L><D><N><R><R><T><L><M><L><L><A><Q><M><S><R><I><S><P><S><S><C><L><M><D><R><H><D><F><G><F><P><Q><E><E><F><D><G><N><Q><F><Q><K><A><P><A><I><S><V><L><H><E><L><I><Q><Q><I><F><N><L><F><T><T><K><D><S><S><A><A><W><D><E><D><L><L><D><K... | Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.<BOP> | P01562 |
Q8N4T4 | ARG39_HUMAN | Rho guanine nucleotide exchange factor 39 | Homo | <M><E><L><S><C><P><G><S><R><C><P><V><Q><E><Q><R><A><R><W><E><R><K><R><A><C><T><A><R><E><L><L><E><T><E><R><R><Y><Q><E><Q><L><G><L><V><A><T><Y><F><L><G><I><L><K><A><K><G><T><L><R><P><P><E><R><Q><A><L><F><G><S><W><E><L><I><Y><G><A><S><Q><E><L><L><P><Y><L><E><G><G><C><W><G><Q><G><L><E><G><F><C><R><H><L><E><L><Y><N><Q><F><A... | Promotes cell proliferation.<BOP> | Q8N4T4 |
O14926 | FSCN2_HUMAN | Retinal fascin | Homo | <M><P><T><N><G><L><H><Q><V><L><K><I><Q><F><G><L><V><N><D><T><D><R><Y><L><T><A><E><S><F><G><F><K><V><N><A><S><A><P><S><L><K><R><K><Q><T><W><V><L><E><P><D><P><G><Q><G><T><A><V><L><L><R><S><S><H><L><G><R><Y><L><S><A><E><E><D><G><R><V><A><C><E><A><E><Q><P><G><R><D><C><R><F><L><V><L><P><Q><P><D><G><R><W><V><L><R><S><E><P><H... | Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.<BOP> | O14926 |
P08217 | CEL2A_HUMAN | Elastase-2A | Homo | <M><I><R><T><L><L><L><S><T><L><V><A><G><A><L><S><C><G><D><P><T><Y><P><P><Y><V><T><R><V><V><G><G><E><E><A><R><P><N><S><W><P><W><Q><V><S><L><Q><Y><S><S><N><G><K><W><Y><H><T><C><G><G><S><L><I><A><N><S><W><V><L><T><A><A><H><C><I><S><S><S><R><T><Y><R><V><G><L><G><R><H><N><L><Y><V><A><E><S><G><S><L><A><V><S><V><S><K><I><V><V... | Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity.<BOP> | P08217 |
Q8N0Y2 | ZN444_HUMAN | Zinc finger and SCAN domain-containing protein 17 | Homo | <M><E><V><A><V><P><V><K><Q><E><A><E><G><L><A><L><D><S><P><W><H><R><F><R><R><F><H><L><G><D><A><P><G><P><R><E><A><L><G><L><L><R><A><L><C><R><D><W><L><R><P><E><V><H><T><K><E><Q><M><L><E><L><L><V><L><E><Q><F><L><S><A><L><P><A><D><T><Q><A><W><V><C><S><R><Q><P><Q><S><G><E><E><A><V><A><L><L><E><E><L><W><G><P><A><A><S><P><D><G... | Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter.<BOP> | Q8N0Y2 |
Q8TBM8 | DJB14_HUMAN | DnaJ homolog subfamily B member 14 | Homo | <M><E><G><N><R><D><E><A><E><K><C><V><E><I><A><R><E><A><L><N><A><G><N><R><E><K><A><Q><R><F><L><Q><K><A><E><K><L><Y><P><L><P><S><A><R><A><L><L><E><I><I><M><K><N><G><S><T><A><G><N><S><P><H><C><R><K><P><S><G><S><G><D><Q><S><K><P><N><C><T><K><D><S><T><S><G><S><G><E><G><G><K><G><Y><T><K><D><Q><V><D><G><V><L><S><I><N><K><C><K... | (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection .<BOP> | Q8TBM8 |
P04921 | GLPC_HUMAN | Sialoglycoprotein D | Homo | <M><W><S><T><R><S><P><N><S><T><A><W><P><L><S><L><E><P><D><P><G><M><A><S><A><S><T><T><M><H><T><T><T><I><A><E><P><D><P><G><M><S><G><W><P><D><G><R><M><E><T><S><T><P><T><I><M><D><I><V><V><I><A><G><V><I><A><A><V><A><I><V><L><V><S><L><L><F><V><M><L><R><Y><M><Y><R><H><K><G><T><Y><H><T><N><E><A><K><G><T><E><F><A><E><S><A><D><A... | This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.<BOP> | P04921 |
Q99645 | EPYC_HUMAN | Small chondroitin/dermatan sulfate proteoglycan | Homo | <M><K><T><L><A><G><L><V><L><G><L><V><I><F><D><A><A><V><T><A><P><T><L><E><S><I><N><Y><D><S><E><T><Y><D><A><T><L><E><D><L><D><N><L><Y><N><Y><E><N><I><P><V><D><K><V><E><I><E><I><A><T><V><M><P><S><G><N><R><E><L><L><T><P><P><P><Q><P><E><K><A><Q><E><E><E><E><E><E><E><S><T><P><R><L><I><D><G><S><S><P><Q><E><P><E><F><T><G><V><L... | May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.<BOP> | Q99645 |
Q99767 | APBA2_HUMAN | Neuronal Munc18-1-interacting protein 2 | Homo | <M><A><H><R><K><L><E><S><V><G><S><G><M><L><D><H><R><V><R><P><G><P><V><P><H><S><Q><E><P><E><S><E><D><M><E><L><P><L><E><G><Y><V><P><E><G><L><E><L><A><A><L><R><P><E><S><P><A><P><E><E><Q><E><C><H><N><H><S><P><D><G><D><S><S><S><D><Y><V><N><N><T><S><E><E><E><D><Y><D><E><G><L><P><E><E><E><E><G><I><T><Y><Y><I><R><Y><C><P><E><D... | Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.<BOP> | Q99767 |
P21695 | GPDA_HUMAN | Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic | Homo | <M><A><S><K><K><V><C><I><V><G><S><G><N><W><G><S><A><I><A><K><I><V><G><G><N><A><A><Q><L><A><Q><F><D><P><R><V><T><M><W><V><F><E><E><D><I><G><G><K><K><L><T><E><I><I><N><T><Q><H><E><N><V><K><Y><L><P><G><H><K><L><P><P><N><V><V><A><V><P><D><V><V><Q><A><A><E><D><A><D><I><L><I><F><V><V><P><H><Q><F><I><G><K><I><C><D><Q><L><K><G... | Has glycerol-3-phosphate dehydrogenase activity.<BOP> | P21695 |
Q9UHV5 | RPGFL_HUMAN | Link guanine nucleotide exchange factor II | Homo | <M><K><P><L><E><K><F><L><K><K><Q><T><S><Q><L><A><G><R><T><V><A><G><G><P><G><G><G><L><G><S><C><G><G><P><G><G><G><G><G><P><G><G><G><G><G><P><A><G><G><Q><R><S><L><Q><R><R><Q><S><V><S><R><L><L><L><P><A><F><L><R><E><P><P><A><E><P><G><L><E><P><P><V><P><E><E><G><G><E><P><A><G><V><A><E><E><P><G><S><G><G><P><C><W><L><Q><L><E><E... | Probable guanine nucleotide exchange factor (GEF).<BOP> | Q9UHV5 |
P60413 | KR10C_HUMAN | Keratin-associated protein 18.12 | Homo | <M><S><V><C><S><S><D><L><S><Y><G><S><R><V><C><L><P><G><S><C><D><S><C><S><D><S><W><Q><V><D><D><C><P><E><S><C><C><E><P><P><C><C><A><P><A><P><C><L><S><L><V><C><T><P><V><S><R><V><S><S><P><C><C><R><V><T><C><E><P><S><P><C><Q><S><G><C><T><S><S><C><T><P><S><C><C><Q><Q><S><S><C><Q><P><A><C><C><T><S><S><P><C><Q><Q><A><C><C><V><P... | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of ha... | P60413 |
Q7Z628 | ARHG8_HUMAN | Rho guanine nucleotide exchange factor 8 | Homo | <M><E><P><E><L><A><A><Q><K><Q><P><R><P><R><R><R><S><R><R><A><S><G><L><S><T><E><G><A><T><G><P><S><A><D><T><S><G><S><E><L><D><G><R><C><S><L><R><R><G><S><S><F><T><F><L><T><P><G><P><N><W><D><F><T><L><K><R><K><R><R><E><K><D><D><D><V><V><S><L><S><S><L><D><L><K><E><P><S><N><K><R><V><R><P><L><A><R><V><T><S><L><A><N><L><I><S><P... | Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.<BOP> | Q7Z628 |
O14519 | CDKA1_HUMAN | Putative oral cancer suppressor | Homo | <M><S><Y><K><P><N><L><A><A><H><M><P><A><A><A><L><N><A><A><G><S><V><H><S><P><S><T><S><M><A><T><S><S><Q><Y><R><Q><L><L><S><D><Y><G><P><P><S><L><G><Y><T><Q><G><T><G><N><S><Q><V><P><Q><S><K><Y><A><E><L><L><A><I><I><E><E><L><G><K><E><I><R><P><T><Y><A><G><S><K><S><A><M><E><R><L><K><R><G><I><I><H><A><R><G><L><V><R><E><C><L><A... | specific inhibitor of the cell-cycle kinase CDK2.<BOP> | O14519 |
Q92685 | ALG3_HUMAN | Not56-like protein | Homo | <M><A><A><G><L><R><K><R><G><R><S><G><S><A><A><Q><A><E><G><L><C><K><Q><W><L><Q><R><A><W><Q><E><R><R><L><L><L><R><E><P><R><Y><T><L><L><V><A><A><C><L><C><L><A><E><V><G><I><T><F><W><V><I><H><R><V><A><Y><T><E><I><D><W><K><A><Y><M><A><E><V><E><G><V><I><N><G><T><Y><D><Y><T><Q><L><Q><G><D><T><G><P><L><V><Y><P><A><G><F><V><Y><I... | Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol.<BOP> | Q92685 |
Q8IVT2 | MISP_HUMAN | Mitotic spindle positioning protein | Homo | <M><D><R><V><T><R><Y><P><I><L><G><I><P><Q><A><H><R><G><T><G><L><V><L><D><G><D><T><S><Y><T><Y><H><L><V><C><M><G><P><E><A><S><G><W><G><Q><D><E><P><Q><T><W><P><T><D><H><R><A><Q><Q><G><V><Q><R><Q><G><V><S><Y><S><V><H><A><Y><T><G><Q><P><S><P><R><G><L><H><S><E><N><R><E><D><E><G><W><Q><V><Y><R><L><G><A><R><D><A><H><Q><G><R><P... | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and fo... | Q8IVT2 |
P24534 | EF1B_HUMAN | Elongation factor 1-beta | Homo | <M><G><F><G><D><L><K><S><P><A><G><L><Q><V><L><N><D><Y><L><A><D><K><S><Y><I><E><G><Y><V><P><S><Q><A><D><V><A><V><F><E><A><V><S><S><P><P><P><A><D><L><C><H><A><L><R><W><Y><N><H><I><K><S><Y><E><K><E><K><A><S><L><P><G><V><K><K><A><L><G><K><Y><G><P><A><D><V><E><D><T><T><G><S><G><A><T><D><S><K><D><D><D><D><I><D><L><F><G><S><D... | EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.<BOP> | P24534 |
Q6UWY2 | PRS57_HUMAN | Serine protease 1-like protein 1 | Homo | <M><G><L><G><L><R><G><W><G><R><P><L><L><T><V><A><T><A><L><M><L><P><V><K><P><P><A><G><S><W><G><A><Q><I><I><G><G><H><E><V><T><P><H><S><R><P><Y><M><A><S><V><R><F><G><G><Q><H><H><C><G><G><F><L><L><R><A><R><W><V><V><S><A><A><H><C><F><S><H><R><D><L><R><T><G><L><V><V><L><G><A><H><V><L><S><T><A><E><P><T><Q><Q><V><F><G><I><D><A... | Serine protease that cleaves preferentially after Arg residues . Can also cleave after citrulline (deimidated arginine) and methylarginine residues .<BOP> | Q6UWY2 |
Q9H1M3 | DB129_HUMAN | Defensin, beta 129 | Homo | <M><K><L><L><F><P><I><F><A><S><L><M><L><Q><Y><Q><V><N><T><E><F><I><G><L><R><R><C><L><M><G><L><G><R><C><R><D><H><C><N><V><D><E><K><E><I><Q><K><C><K><M><K><K><C><C><V><G><P><K><V><V><K><L><I><K><N><Y><L><Q><Y><G><T><P><N><V><L><N><E><D><V><Q><E><M><L><K><P><A><K><N><S><S><A><V><I><Q><R><K><H><I><L><S><V><L><P><Q><I><K><S... | Has antibacterial activity.<BOP> | Q9H1M3 |
Q8NBF2 | NHLC2_HUMAN | NHL repeat-containing protein 2 | Homo | <M><A><A><P><G><G><R><G><R><S><L><S><G><L><L><P><A><Q><T><S><L><E><Y><A><L><L><D><A><V><T><Q><Q><E><K><D><S><L><V><Y><Q><Y><L><Q><K><V><D><G><W><E><Q><D><L><S><V><P><E><F><P><E><G><L><E><W><L><N><T><E><E><P><I><S><V><Y><K><D><L><C><G><K><I><V><V><L><D><F><F><T><Y><C><C><I><N><C><I><H><L><L><P><D><L><H><A><L><E><H><T><Y... | Required for normal embryonic development.<BOP> | Q8NBF2 |
Q9NP55 | BPIA1_HUMAN | Von Ebner protein Hl | Homo | <M><F><Q><T><G><G><L><I><V><F><Y><G><L><L><A><Q><T><M><A><Q><F><G><G><L><P><V><P><L><D><Q><T><L><P><L><N><V><N><P><A><L><P><L><S><P><T><G><L><A><G><S><L><T><N><A><L><S><N><G><L><L><S><G><G><L><L><G><I><L><E><N><L><P><L><L><D><I><L><K><P><G><G><G><T><S><G><G><L><L><G><G><L><L><G><K><V><T><S><V><I><P><G><L><N><N><I><I><D... | Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) . Plays a role in the innate immune responses of the upper airways . Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative ... | Q9NP55 |
A6NDH6 | O5H15_HUMAN | Olfactory receptor 5H15 | Homo | <M><E><E><E><N><A><T><L><L><T><E><F><V><L><T><G><F><L><Y><Q><P><Q><W><K><I><P><L><F><L><A><F><L><V><I><Y><L><I><T><I><M><G><N><L><G><L><I><A><V><I><W><K><D><P><H><L><H><I><P><M><Y><L><L><L><G><N><L><A><F><V><D><A><W><I><S><S><T><V><T><P><K><M><L><N><N><F><L><A><K><S><K><M><I><S><L><S><E><C><K><I><Q><F><F><S><I><A><I><G... | Odorant receptor.<BOP> | A6NDH6 |
P0CJ72 | HMN5_HUMAN | MT-RNR2-like protein 5 | Homo | <M><A><T><P><G><F><S><C><L><L><L><S><T><S><E><I><D><L><P><M><K><R><R><V> | Plays a role as a neuroprotective and antiapoptotic factor.<BOP> | P0CJ72 |
Q9Y6B2 | EID1_HUMAN | E1A-like inhibitor of differentiation 1 | Homo | <M><S><E><M><A><E><L><S><E><L><Y><E><E><S><S><D><L><Q><M><D><V><M><P><G><E><G><D><L><P><Q><M><E><V><G><S><G><S><R><E><L><S><L><R><P><S><R><S><G><A><Q><Q><L><E><E><E><G><P><M><E><E><E><E><A><Q><P><M><A><A><P><E><G><K><R><S><L><A><N><G><P><N><A><G><E><Q><P><G><Q><V><A><G><A><D><F><E><S><E><D><E><G><E><E><F><D><D><W><E><D... | Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 tha... | Q9Y6B2 |
Q96CS3 | FAF2_HUMAN | UBX domain-containing protein 8 | Homo | <M><A><A><P><E><E><R><D><L><T><Q><E><Q><T><E><K><L><L><Q><F><Q><D><L><T><G><I><E><S><M><D><Q><C><R><H><T><L><E><Q><H><N><W><N><I><E><A><A><V><Q><D><R><L><N><E><Q><E><G><V><P><S><V><F><N><P><P><P><S><R><P><L><Q><V><N><T><A><D><H><R><I><Y><S><Y><V><V><S><R><P><Q><P><R><G><L><L><G><W><G><Y><Y><L><I><M><L><P><F><R><F><T><Y... | Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins . By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway . In... | Q96CS3 |
O60542 | PSPN_HUMAN | Persephin | Homo | <M><A><V><G><K><F><L><L><G><S><L><L><L><L><S><L><Q><L><G><Q><G><W><G><P><D><A><R><G><V><P><V><A><D><G><E><F><S><S><E><Q><V><A><K><A><G><G><T><W><L><G><T><H><R><P><L><A><R><L><R><R><A><L><S><G><P><C><Q><L><W><S><L><T><L><S><V><A><E><L><G><L><G><Y><A><S><E><E><K><V><I><F><R><Y><C><A><G><S><C><P><R><G><A><R><T><Q><H><G><L... | Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.<BOP> | O60542 |
Q10713 | MPPA_HUMAN | P-55 | Homo | <M><A><A><V><V><L><A><A><T><R><L><L><R><G><S><G><S><W><G><C><S><R><L><R><F><G><P><P><A><Y><R><R><F><S><S><G><G><A><Y><P><N><I><P><L><S><S><P><L><P><G><V><P><K><P><V><F><A><T><V><D><G><Q><E><K><F><E><T><K><V><T><T><L><D><N><G><L><R><V><A><S><Q><N><K><F><G><Q><F><C><T><V><G><I><L><I><N><S><G><S><R><Y><E><A><K><Y><L><S><G... | Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.<BOP> | Q10713 |
Q9BY10 | TSCOT_HUMAN | Solute carrier family 46 member 2 | Homo | <M><S><P><E><V><T><C><P><R><R><G><H><L><P><R><F><H><P><R><T><W><V><E><P><V><V><A><S><S><Q><V><A><A><S><L><Y><D><A><G><L><L><L><V><V><K><A><S><Y><G><T><G><G><S><S><N><H><S><A><S><P><S><P><R><G><A><L><E><D><Q><Q><Q><R><A><I><S><N><F><Y><I><I><Y><N><L><V><V><G><L><S><P><L><L><S><A><Y><G><L><G><W><L><S><D><R><Y><H><R><K><I... | May act as a transporter.<BOP> | Q9BY10 |
Q3LI77 | KR134_HUMAN | Keratin-associated protein 13-4 | Homo | <M><S><Y><N><C><C><S><R><N><F><S><S><R><S><F><G><G><Y><L><Y><Y><P><G><S><Y><P><S><S><L><V><Y><S><T><A><L><C><S><P><S><T><C><Q><L><R><S><S><L><Y><R><D><C><Q><K><T><C><W><E><P><A><S><C><Q><K><S><C><Y><R><P><R><T><S><I><L><C><C><P><C><Q><T><T><C><S><G><S><L><G><F><R><S><S><S><C><R><S><Q><G><Y><G><S><R><C><C><Y><S><L><G><N... | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of ha... | Q3LI77 |
P32881 | IFNA8_HUMAN | Interferon alpha-B2 | Homo | <M><A><L><T><F><Y><L><L><V><A><L><V><V><L><S><Y><K><S><F><S><S><L><G><C><D><L><P><Q><T><H><S><L><G><N><R><R><A><L><I><L><L><A><Q><M><R><R><I><S><P><F><S><C><L><K><D><R><H><D><F><E><F><P><Q><E><E><F><D><D><K><Q><F><Q><K><A><Q><A><I><S><V><L><H><E><M><I><Q><Q><T><F><N><L><F><S><T><K><D><S><S><A><A><L><D><E><T><L><L><D><E... | Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.<BOP> | P32881 |
P31943 | HNRH1_HUMAN | Heterogeneous nuclear ribonucleoprotein H, N-terminally processed | Homo | <M><M><L><G><T><E><G><G><E><G><F><V><V><K><V><R><G><L><P><W><S><C><S><A><D><E><V><Q><R><F><F><S><D><C><K><I><Q><N><G><A><Q><G><I><R><F><I><Y><T><R><E><G><R><P><S><G><E><A><F><V><E><L><E><S><E><D><E><V><K><L><A><L><K><K><D><R><E><T><M><G><H><R><Y><V><E><V><F><K><S><N><N><V><E><M><D><W><V><L><K><H><T><G><P><N><S><P><D><T... | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, in... | P31943 |
P31391 | SSR4_HUMAN | Somatostatin receptor type 4 | Homo | <M><S><A><P><S><T><L><P><P><G><G><E><E><G><L><G><T><A><W><P><S><A><A><N><A><S><S><A><P><A><E><A><E><E><A><V><A><G><P><G><D><A><R><A><A><G><M><V><A><I><Q><C><I><Y><A><L><V><C><L><V><G><L><V><G><N><A><L><V><I><F><V><I><L><R><Y><A><K><M><K><T><A><T><N><I><Y><L><L><N><L><A><V><A><D><E><L><F><M><L><S><V><P><F><V><A><S><S><A... | Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferativ... | P31391 |
Q765I0 | UTS2B_HUMAN | Urotensin-2 domain-containing protein | Homo | <M><N><K><I><L><S><S><T><V><C><F><G><L><L><T><L><L><S><V><L><S><F><L><Q><S><V><H><G><R><P><Y><L><T><Q><G><N><E><I><F><P><D><K><K><Y><T><N><R><E><E><L><L><L><A><L><L><N><K><N><F><D><F><Q><R><P><F><N><T><D><L><A><L><P><N><K><L><E><E><L><N><Q><L><E><K><L><K><E><Q><L><V><E><E><K><D><S><E><T><S><Y><A><V><D><G><L><F><S><S><H... | Potent vasoconstrictor.<BOP> | Q765I0 |
P28062 | PSB8_HUMAN | Really interesting new gene 10 protein | Homo | <M><A><L><L><D><V><C><G><A><P><R><G><Q><R><P><E><S><A><L><P><V><A><G><S><G><R><R><S><D><P><G><H><Y><S><F><S><M><R><S><P><E><L><A><L><P><R><G><M><Q><P><T><E><F><F><Q><S><L><G><G><D><G><E><R><N><V><Q><I><E><M><A><H><G><T><T><T><L><A><F><K><F><Q><H><G><V><I><A><A><V><D><S><R><A><S><A><G><S><Y><I><S><A><L><R><V><N><K><V><I... | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to gener... | P28062 |
Q12794 | HYAL1_HUMAN | Lung carcinoma protein 1 | Homo | <M><A><A><H><L><L><P><I><C><A><L><F><L><T><L><L><D><M><A><Q><G><F><R><G><P><L><L><P><N><R><P><F><T><T><V><W><N><A><N><T><Q><W><C><L><E><R><H><G><V><D><V><D><V><S><V><F><D><V><V><A><N><P><G><Q><T><F><R><G><P><D><M><T><I><F><Y><S><S><Q><L><G><T><Y><P><Y><Y><T><P><T><G><E><P><V><F><G><G><L><P><Q><N><A><S><L><I><A><H><L><A... | May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.<BOP> | Q12794 |
Q9UKM7 | MA1B1_HUMAN | Mannosidase alpha class 1B member 1 | Homo | <M><A><A><C><E><G><R><R><S><G><A><L><G><S><S><Q><S><D><F><L><T><P><P><V><G><G><A><P><W><A><V><A><T><T><V><V><M><Y><P><P><P><P><P><P><P><H><R><D><F><I><S><V><T><L><S><F><G><E><N><Y><D><N><S><K><S><W><R><R><R><S><C><W><R><K><W><K><Q><L><S><R><L><Q><R><N><M><I><L><F><L><L><A><F><L><L><F><C><G><L><L><F><Y><I><N><L><A><D><H... | Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carb... | Q9UKM7 |
Q5JU00 | DRC5_HUMAN | T-complex-associated testis-expressed protein 1 | Homo | <M><Q><D><T><V><T><T><S><A><L><L><D><P><S><H><S><S><V><S><T><Q><D><N><S><S><T><G><G><H><T><S><S><T><S><P><Q><L><S><K><P><S><I><T><P><V><P><A><K><S><R><N><P><H><P><R><A><N><I><R><R><M><R><R><I><I><A><E><D><P><E><W><S><L><A><I><V><P><L><L><T><E><L><C><I><Q><H><I><I><R><N><F><Q><K><N><P><I><L><K><Q><M><L><P><E><H><Q><Q><K... | Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility.<BOP> | Q5JU00 |
P15976 | GATA1_HUMAN | NF-E1 DNA-binding protein | Homo | <M><E><F><P><G><L><G><S><L><G><T><S><E><P><L><P><Q><F><V><D><P><A><L><V><S><S><T><P><E><S><G><V><F><F><P><S><G><P><E><G><L><D><A><A><A><S><S><T><A><P><S><T><A><T><A><A><A><A><A><L><A><Y><Y><R><D><A><E><A><Y><R><H><S><P><V><F><Q><V><Y><P><L><L><N><C><M><E><G><I><P><G><G><S><P><Y><A><G><W><A><Y><G><K><T><G><L><Y><P><A><S... | Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved... | P15976 |
Q9HBU6 | EKI1_HUMAN | Ethanolamine kinase 1 | Homo | <M><L><C><G><R><P><R><S><S><S><D><N><R><N><F><L><R><E><R><A><G><L><S><S><A><A><V><Q><T><R><I><G><N><S><A><A><S><R><R><S><P><A><A><R><P><P><V><P><A><P><P><A><L><P><R><G><R><P><G><T><E><G><S><T><S><L><S><A><P><A><V><L><V><V><A><V><A><V><V><V><V><V><V><S><A><V><A><W><A><M><A><N><Y><I><H><V><P><P><G><S><P><E><V><P><K><L><N... | Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.<BOP> | Q9HBU6 |
O96009 | NAPSA_HUMAN | TA01/TA02 | Homo | <M><S><P><P><P><L><L><Q><P><L><L><L><L><L><P><L><L><N><V><E><P><S><G><A><T><L><I><R><I><P><L><H><R><V><Q><P><G><R><R><I><L><N><L><L><R><G><W><R><E><P><A><E><L><P><K><L><G><A><P><S><P><G><D><K><P><I><F><V><P><L><S><N><Y><R><D><V><Q><Y><F><G><E><I><G><L><G><T><P><P><Q><N><F><T><V><A><F><D><T><G><S><S><N><L><W><V><P><S><R... | May be involved in processing of pneumocyte surfactant precursors.<BOP> | O96009 |
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