accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
P15813 | CD1D_HUMAN | R3G1 | Homo | <M><G><C><L><L><F><L><L><L><W><A><L><L><Q><A><W><G><S><A><E><V><P><Q><R><L><F><P><L><R><C><L><Q><I><S><S><F><A><N><S><S><W><T><R><T><D><G><L><A><W><L><G><E><L><Q><T><H><S><W><S><N><D><S><D><T><V><R><S><L><K><P><W><S><Q><G><T><F><S><D><Q><Q><W><E><T><L><Q><H><I><F><R><V><Y><R><S><S><F><T><R><D><V><K><E><F><A><K><M><L><R><L><S><Y><P><L><E><L><Q><V><S><A><G><C><E><V><H><P><G><N><A><S><N><N><F><F><H><V><A><F><Q><G><K><D><I><L><S><F><Q><G><T><S><W><E><P><T><Q><E><A><P><L><W><V><N><L><A><I><Q><V><L><N><Q><D><K><W><T><R><E><T><V><Q><W><L><L><N><G><T><C><P><Q><F><V><S><G><L><L><E><S><G><K><S><E><L><K><K><Q><V><K><P><K><A><W><L><S><R><G><P><S><P><G><P><G><R><L><L><L><V><C><H><V><S><G><F><Y><P><K><P><V><W><V><K><W><M><R><G><E><Q><E><Q><Q><G><T><Q><P><G><D><I><L><P><N><A><D><E><T><W><Y><L><R><A><T><L><D><V><V><A><G><E><A><A><G><L><S><C><R><V><K><H><S><S><L><E><G><Q><D><I><V><L><Y><W><G><G><S><Y><T><S><M><G><L><I><A><L><A><V><L><A><C><L><L><F><L><L><I><V><G><F><T><S><R><F><K><R><Q><T><S><Y><Q><G><V><L> | Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<BOP> | P15813 |
A6NDV4 | TMM8B_HUMAN | Protein NGX6 | Homo | <M><N><M><P><Q><S><L><G><N><Q><P><L><P><P><E><P><P><S><L><G><T><P><A><E><G><P><G><T><T><S><P><P><E><H><C><W><P><V><R><P><T><L><R><N><E><L><D><T><F><S><V><H><F><Y><I><F><F><G><P><S><V><A><L><P><P><E><R><P><A><V><F><A><M><R><L><L><P><V><L><D><S><G><G><V><L><S><L><E><L><Q><L><N><A><S><S><V><R><Q><E><N><V><T><V><F><G><C><L><T><H><E><V><P><L><S><L><G><D><A><A><V><T><C><S><K><E><S><L><A><G><F><L><L><S><V><S><A><T><T><R><V><A><R><L><R><I><P><F><P><Q><T><G><T><W><F><L><A><L><R><S><L><C><G><V><G><P><R><F><V><R><C><R><N><A><T><A><E><V><R><M><R><T><F><L><S><P><C><V><D><D><C><G><P><Y><G><Q><C><K><L><L><R><T><H><N><Y><L><Y><A><A><C><E><C><K><A><G><W><R><G><W><G><C><T><D><S><A><D><A><L><T><Y><G><F><Q><L><L><S><T><L><L><L><C><L><S><N><L><M><F><L><P><P><V><V><L><A><I><R><S><R><Y><V><L><E><A><A><V><Y><T><F><T><M><F><F><S><T><F><Y><H><A><C><D><Q><P><G><I><V><V><F><C><I><M><D><Y><D><V><L><Q><F><C><D><F><L><G><S><L><M><S><V><W><V><T><V><I><A><M><A><R><L><Q><P><V><V><K><Q><V><L><Y><L><L><G><A><M><L><L><S><M><A><L><Q><L><D><R><H><G><L><W><N><L><L><G><P><S><L><F><A><L><G><I><L><A><T><A><W><T><V><R><S><V><R><R><R><H><C><Y><P><P><T><W><R><R><W><L><F><Y><L><C><P><G><S><L><I><A><G><S><A><V><L><L><Y><A><F><V><E><T><R><D><N><Y><F><Y><I><H><S><I><W><H><M><L><I><A><G><S><V><G><F><L><L><P><P><R><A><K><T><D><H><G><V><P><S><G><A><R><A><R><G><C><G><Y><Q><L><C><I><N><E><Q><E><E><L><G><L><V><G><P><G><G><A><T><V><S><S><I><C><A><S> | May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.<BOP> | A6NDV4 |
P54710 | ATNG_HUMAN | Sodium pump gamma chain | Homo | <M><T><G><L><S><M><D><G><G><G><S><P><K><G><D><V><D><P><F><Y><Y><D><Y><E><T><V><R><N><G><G><L><I><F><A><G><L><A><F><I><V><G><L><L><I><L><L><S><R><R><F><R><C><G><G><N><K><K><R><R><Q><I><N><E><D><E><P> | May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.<BOP> | P54710 |
Q6IE38 | ISK14_HUMAN | Serine protease inhibitor Kazal-type 14 | Homo | <M><A><K><S><F><P><V><F><S><L><L><S><F><I><L><I><H><L><V><L><S><S><V><S><G><P><R><H><W><W><P><P><R><G><I><I><K><V><K><C><P><Y><E><K><V><N><L><S><W><Y><N><G><T><V><N><P><C><P><G><L><Y><Q><P><I><C><G><T><N><F><I><T><Y><D><N><P><C><I><L><C><V><E><S><L><K><S><H><G><R><I><R><F><Y><H><D><G><K><C> | May be a serine protease inhibitor.<BOP> | Q6IE38 |
Q8N823 | ZN611_HUMAN | Zinc finger protein 611 | Homo | <M><L><R><E><E><A><A><Q><K><R><K><G><K><E><P><G><M><A><L><P><Q><G><R><L><T><F><R><D><V><A><I><E><F><S><L><A><E><W><K><C><L><N><P><S><Q><R><A><L><Y><R><E><V><M><L><E><N><Y><R><N><L><E><A><V><D><I><S><S><K><C><M><M><K><E><V><L><S><T><G><Q><G><N><T><E><V><I><H><T><G><T><L><Q><R><H><E><S><H><H><I><G><D><F><C><F><Q><E><I><E><K><E><I><H><D><I><E><F><Q><C><Q><E><D><E><R><N><G><L><E><A><P><M><T><K><I><K><K><L><T><G><S><T><D><Q><H><D><H><R><H><A><G><N><K><P><I><K><D><Q><L><G><S><S><F><Y><S><H><L><P><E><L><H><I><F><Q><I><K><G><E><I><G><N><Q><L><E><K><S><T><N><D><A><P><S><V><S><T><F><Q><R><I><S><C><R><P><Q><T><Q><I><S><N><N><Y><G><N><N><P><L><N><S><S><L><L><P><Q><K><Q><E><V><H><M><R><E><K><S><F><Q><C><N><K><S><G><K><A><F><N><C><S><S><L><L><R><K><H><Q><I><P><H><L><G><D><K><Q><Y><K><C><D><V><C><G><K><L><F><N><H><E><Q><Y><L><A><C><H><D><R><C><H><T><V><E><K><P><Y><K><C><K><E><C><G><K><T><F><S><Q><E><S><S><L><T><C><H><R><R><L><H><T><G><V><K><R><Y><N><C><N><E><C><G><K><I><F><G><Q><N><S><A><L><L><I><D><K><A><I><D><T><G><E><N><P><Y><K><C><N><E><C><D><K><A><F><N><Q><Q><S><Q><L><S><H><H><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><D><K><V><F><S><R><K><S><T><I><E><T><H><K><R><I><H><T><G><E><K><P><Y><R><C><K><V><C><D><T><A><F><T><W><H><S><Q><L><A><R><H><R><R><I><H><T><A><K><K><T><Y><K><C><N><E><C><G><K><T><F><S><H><K><S><S><L><V><C><H><H><R><L><H><G><G><E><K><S><Y><K><C><K><V><C><D><K><A><F><V><W><S><S><Q><L><A><K><H><T><R><I><D><C><G><E><K><P><Y><K><C><N><E><C><G><K><T><F><G><Q><N><S><D><L><L><I><H><K><S><I><H><T><G><E><Q><P><Y><K><C><D><E><C><E><K><V><F><S><R><K><S><S><L><E><T><H><K><I><G><H><T><G><E><K><P><Y><K><C><K><V><C><D><K><A><F><A><C><H><S><Y><L><A><K><H><T><R><I><H><S><G><E><K><P><Y><K><C><N><E><C><S><K><T><F><S><H><R><S><Y><L><V><C><H><H><R><V><H><S><G><E><K><P><Y><K><C><N><E><C><S><K><T><F><S><R><R><S><S><L><H><C><H><R><R><L><H><S><G><E><K><P><Y><K><C><N><E><C><G><N><T><F><R><H><C><S><S><L><I><Y><H><R><R><L><H><T><G><E><K><S><Y><K><C><T><I><C><D><K><A><F><V><R><N><S><L><L><S><R><H><T><R><I><H><T><A><E><K><P><Y><K><C><N><E><C><G><K><A><F><N><Q><Q><S><H><L><S><R><H><H><R><I><H><T><G><E><K><P> | May be involved in transcriptional regulation.<BOP> | Q8N823 |
Q96HU1 | SGSM3_HUMAN | Rab-GTPase-activating protein-like protein | Homo | <M><S><G><S><H><T><P><A><C><G><P><F><S><A><L><T><P><S><I><W><P><Q><E><I><L><A><K><Y><T><Q><K><E><E><S><A><E><Q><P><E><F><Y><Y><D><E><F><G><F><R><V><Y><K><E><E><G><D><E><P><G><S><S><L><L><A><N><S><P><L><M><E><D><A><P><Q><R><L><R><W><Q><A><H><L><E><F><T><H><N><H><D><V><G><D><L><T><W><D><K><I><A><V><S><L><P><R><S><E><K><L><R><S><L><V><L><A><G><I><P><H><G><M><R><P><Q><L><W><M><R><L><S><G><A><L><Q><K><K><R><N><S><E><L><S><Y><R><E><I><V><K><N><S><S><N><D><E><T><I><A><A><K><Q><I><E><K><D><L><L><R><T><M><P><S><N><A><C><F><A><S><M><G><S><I><G><V><P><R><L><R><R><V><L><R><A><L><A><W><L><Y><P><E><I><G><Y><C><Q><G><T><G><M><V><A><A><C><L><L><L><F><L><E><E><E><D><A><F><W><M><M><S><A><I><I><E><D><L><L><P><A><S><Y><F><S><T><T><L><L><G><V><Q><T><D><Q><R><V><L><R><H><L><I><V><Q><Y><L><P><R><L><D><K><L><L><Q><E><H><D><I><E><L><S><L><I><T><L><H><W><F><L><T><A><F><A><S><V><V><D><I><K><L><L><L><R><I><W><D><L><F><F><Y><E><G><S><R><V><L><F><Q><L><T><L><G><M><L><H><L><K><E><E><E><L><I><Q><S><E><N><S><A><S><I><F><N><T><L><S><D><I><P><S><Q><M><E><D><A><E><L><L><L><G><V><A><M><R><L><A><G><S><L><T><D><V><A><V><E><T><Q><R><R><K><H><L><A><Y><L><I><A><D><Q><G><Q><L><L><G><A><G><T><L><T><N><L><S><Q><V><V><R><R><R><T><Q><R><R><K><S><T><I><T><A><L><L><F><G><E><D><D><L><E><A><L><K><A><K><N><I><K><Q><T><E><L><V><A><D><L><R><E><A><I><L><R><V><A><R><H><F><Q><C><T><D><P><K><N><C><S><V><E><L><T><P><D><Y><S><M><E><S><H><Q><R><D><H><E><N><Y><V><A><C><S><R><S><H><R><R><R><A><K><A><L><L><D><F><E><R><H><D><D><D><E><L><G><F><R><K><N><D><I><I><T><I><V><S><Q><K><D><E><H><C><W><V><G><E><L><N><G><L><R><G><W><F><P><A><K><F><V><E><V><L><D><E><R><S><K><E><Y><S><I><A><G><D><D><S><V><T><E><G><V><T><D><L><V><R><G><T><L><C><P><A><L><K><A><L><F><E><H><G><L><K><K><P><S><L><L><G><G><A><C><H><P><W><L><F><I><E><E><A><A><G><R><E><V><E><R><D><F><A><S><V><Y><S><R><L><V><L><C><K><T><F><R><L><D><E><D><G><K><V><L><T><P><E><E><L><L><Y><R><A><V><Q><S><V><N><V><T><H><D><A><V><H><A><Q><M><D><V><K><L><R><S><L><I><C><V><G><L><N><E><Q><V><L><H><L><W><L><E><V><L><C><S><S><L><P><T><V><E><K><W><Y><Q><P><W><S><F><L><R><S><P><G><W><V><Q><I><K><C><E><L><R><V><L><C><C><F><A><F><S><L><S><Q><D><W><E><L><P><A><K><R><E><A><Q><Q><P><L><K><E><G><V><R><D><M><L><V><K><H><H><L><F><S><W><D><V><D><G> | May play a cooperative role in NF2-mediated growth suppression of cells.<BOP> | Q96HU1 |
Q9NUQ2 | PLCE_HUMAN | Lysophosphatidic acid acyltransferase epsilon | Homo | <M><L><L><S><L><V><L><H><T><Y><S><M><R><Y><L><L><P><S><V><V><L><L><G><T><A><P><T><Y><V><L><A><W><G><V><W><R><L><L><S><A><F><L><P><A><R><F><Y><Q><A><L><D><D><R><L><Y><C><V><Y><Q><S><M><V><L><F><F><F><E><N><Y><T><G><V><Q><I><L><L><Y><G><D><L><P><K><N><K><E><N><I><I><Y><L><A><N><H><Q><S><T><V><D><W><I><V><A><D><I><L><A><I><R><Q><N><A><L><G><H><V><R><Y><V><L><K><E><G><L><K><W><L><P><L><Y><G><C><Y><F><A><Q><H><G><G><I><Y><V><K><R><S><A><K><F><N><E><K><E><M><R><N><K><L><Q><S><Y><V><D><A><G><T><P><M><Y><L><V><I><F><P><E><G><T><R><Y><N><P><E><Q><T><K><V><L><S><A><S><Q><A><F><A><A><Q><R><G><L><A><V><L><K><H><V><L><T><P><R><I><K><A><T><H><V><A><F><D><C><M><K><N><Y><L><D><A><I><Y><D><V><T><V><V><Y><E><G><K><D><D><G><G><Q><R><R><E><S><P><T><M><T><E><F><L><C><K><E><C><P><K><I><H><I><H><I><D><R><I><D><K><K><D><V><P><E><E><Q><E><H><M><R><R><W><L><H><E><R><F><E><I><K><D><K><M><L><I><E><F><Y><E><S><P><D><P><E><R><R><K><R><F><P><G><K><S><V><N><S><K><L><S><I><K><K><T><L><P><S><M><L><I><L><S><G><L><T><A><G><M><L><M><T><D><A><G><R><K><L><Y><V><N><T><W><I><Y><G><T><L><L><G><C><L><W><V><T><I><K><A> | Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone . Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor . Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA . Activity toward lysophosphatidylglycerol not detectable .<BOP> | Q9NUQ2 |
O14810 | CPLX1_HUMAN | Synaphin-2 | Homo | <M><E><F><V><M><K><Q><A><L><G><G><A><T><K><D><M><G><K><M><L><G><G><D><E><E><K><D><P><D><A><A><K><K><E><E><E><R><Q><E><A><L><R><Q><A><E><E><E><R><K><A><K><Y><A><K><M><E><A><E><R><E><A><V><R><Q><G><I><R><D><K><Y><G><I><K><K><K><E><E><R><E><A><E><A><Q><A><A><M><E><A><N><S><E><G><S><L><T><R><P><K><K><A><I><P><P><G><C><G><D><E><V><E><E><E><D><E><S><I><L><D><T><V><I><K><Y><L><P><G><P><L><Q><D><M><L><K><K> | Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles . Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse . Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.<BOP> | O14810 |
P54840 | GYS2_HUMAN | Glycogen [starch] synthase, liver | Homo | <M><L><R><G><R><S><L><S><V><T><S><L><G><G><L><P><Q><W><E><V><E><E><L><P><V><E><E><L><L><L><F><E><V><A><W><E><V><T><N><K><V><G><G><I><Y><T><V><I><Q><T><K><A><K><T><T><A><D><E><W><G><E><N><Y><F><L><I><G><P><Y><F><E><H><N><M><K><T><Q><V><E><Q><C><E><P><V><N><D><A><V><R><R><A><V><D><A><M><N><K><H><G><C><Q><V><H><F><G><R><W><L><I><E><G><S><P><Y><V><V><L><F><D><I><G><Y><S><A><W><N><L><D><R><W><K><G><D><L><W><E><A><C><S><V><G><I><P><Y><H><D><R><E><A><N><D><M><L><I><F><G><S><L><T><A><W><F><L><K><E><V><T><D><H><A><D><G><K><Y><V><V><A><Q><F><H><E><W><Q><A><G><I><G><L><I><L><S><R><A><R><K><L><P><I><A><T><I><F><T><T><H><A><T><L><L><G><R><Y><L><C><A><A><N><I><D><F><Y><N><H><L><D><K><F><N><I><D><K><E><A><G><E><R><Q><I><Y><H><R><Y><C><M><E><R><A><S><V><H><C><A><H><V><F><T><T><V><S><E><I><T><A><I><E><A><E><H><M><L><K><R><K><P><D><V><V><T><P><N><G><L><N><V><K><K><F><S><A><V><H><E><F><Q><N><L><H><A><M><Y><K><A><R><I><Q><D><F><V><R><G><H><F><Y><G><H><L><D><F><D><L><E><K><T><L><F><L><F><I><A><G><R><Y><E><F><S><N><K><G><A><D><I><F><L><E><S><L><S><R><L><N><F><L><L><R><M><H><K><S><D><I><T><V><M><V><F><F><I><M><P><A><K><T><N><N><F><N><V><E><T><L><K><G><Q><A><V><R><K><Q><L><W><D><V><A><H><S><V><K><E><K><F><G><K><K><L><Y><D><A><L><L><R><G><E><I><P><D><L><N><D><I><L><D><R><D><D><L><T><I><M><K><R><A><I><F><S><T><Q><R><Q><S><L><P><P><V><T><T><H><N><M><I><D><D><S><T><D><P><I><L><S><T><I><R><R><I><G><L><F><N><N><R><T><D><R><V><K><V><I><L><H><P><E><F><L><S><S><T><S><P><L><L><P><M><D><Y><E><E><F><V><R><G><C><H><L><G><V><F><P><S><Y><Y><E><P><W><G><Y><T><P><A><E><C><T><V><M><G><I><P><S><V><T><T><N><L><S><G><F><G><C><F><M><Q><E><H><V><A><D><P><T><A><Y><G><I><Y><I><V><D><R><R><F><R><S><P><D><D><S><C><N><Q><L><T><K><F><L><Y><G><F><C><K><Q><S><R><R><Q><R><I><I><Q><R><N><R><T><E><R><L><S><D><L><L><D><W><R><Y><L><G><R><Y><Y><Q><H><A><R><H><L><T><L><S><R><A><F><P><D><K><F><H><V><E><L><T><S><P><P><T><T><E><G><F><K><Y><P><R><P><S><S><V><P><P><S><P><S><G><S><Q><A><S><S><P><Q><S><S><D><V><E><D><E><V><E><D><E><R><Y><D><E><E><E><E><A><E><R><D><R><L><N><I><K><S><P><F><S><L><S><H><V><P><H><G><K><K><K><L><H><G><E><Y><K><N> | Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.<BOP> | P54840 |
Q6ZTN6 | AN13D_HUMAN | Ankyrin repeat domain-containing protein 13D | Homo | <M><A><G><P><G><P><T><F><P><L><H><R><L><V><W><A><N><R><H><R><E><L><E><A><A><L><H><S><H><Q><H><D><I><E><Q><E><D><P><R><G><R><T><P><L><E><L><A><V><S><L><G><N><L><E><S><V><R><V><L><L><R><H><N><A><N><V><G><K><E><N><R><Q><G><W><A><V><L><Q><E><A><V><S><T><G><D><P><E><M><V><Q><L><V><L><Q><Y><R><D><Y><Q><R><A><T><Q><R><L><A><G><I><P><E><L><L><N><K><L><R><Q><A><P><D><F><Y><V><E><M><K><W><E><F><T><S><W><V><P><L><V><S><K><M><C><P><S><D><V><Y><R><V><W><K><R><G><E><S><L><R><V><D><T><S><L><L><G><F><E><H><M><T><W><Q><R><G><R><R><S><F><I><F><K><G><Q><E><A><G><A><L><V><M><E><V><D><H><D><R><Q><V><V><H><V><E><T><L><G><L><T><L><Q><E><P><E><T><L><L><A><A><M><R><P><S><E><E><H><V><A><S><R><L><T><S><P><I><V><S><T><H><L><D><T><R><N><V><A><F><E><R><N><K><C><G><I><W><G><W><R><S><E><K><M><E><T><V><S><G><Y><E><A><K><V><Y><S><A><T><N><V><E><L><V><T><R><T><R><T><E><H><L><S><D><Q><D><K><S><R><S><K><A><G><K><T><P><F><Q><S><F><L><G><M><A><Q><Q><H><S><S><H><T><G><A><P><V><Q><Q><A><A><S><P><T><N><P><T><A><I><S><P><E><E><Y><F><D><P><N><F><S><L><E><S><R><N><I><G><R><P><I><E><M><S><S><K><V><Q><R><F><K><A><T><L><W><L><S><E><E><H><P><L><S><L><G><D><Q><V><T><P><I><I><D><L><M><A><I><S><N><A><H><F><A><K><L><R><D><F><I><T><L><R><L><P><P><G><F><P><V><K><I><E><I><P><L><F><H><V><L><N><A><R><I><T><F><S><N><L><C><G><C><D><E><P><L><S><S><V><W><V><P><A><P><S><S><A><V><A><A><S><G><N><P><F><P><C><E><V><D><P><T><V><F><E><V><P><N><G><Y><S><V><L><G><M><E><R><N><E><P><L><R><D><E><D><D><D><L><L><Q><F><A><I><Q><Q><S><L><L><E><A><G><T><E><A><E><Q><V><T><V><W><E><A><L><T><N><T><R><P><G><A><R><P><P><P><Q><A><T><V><Y><E><E><Q><L><Q><L><E><R><A><L><Q><E><S><L><Q><L><S><T><E><P><R><G><P><G><S><P><P><R><T><P><P><A><P><G><P><P><S><F><E><E><Q><L><R><L><A><L><E><L><S><S><R><E><Q><E><E><R><E><R><R><G><Q><Q><E><E><E><D><L><Q><R><I><L><Q><L><S><L><T><E><H> | Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.<BOP> | Q6ZTN6 |
P50461 | CSRP3_HUMAN | Muscle LIM protein | Homo | <M><P><N><W><G><G><G><A><K><C><G><A><C><E><K><T><V><Y><H><A><E><E><I><Q><C><N><G><R><S><F><H><K><T><C><F><H><C><M><A><C><R><K><A><L><D><S><T><T><V><A><A><H><E><S><E><I><Y><C><K><V><C><Y><G><R><R><Y><G><P><K><G><I><G><Y><G><Q><G><A><G><C><L><S><T><D><T><G><E><H><L><G><L><Q><F><Q><Q><S><P><K><P><A><R><S><V><T><T><S><N><P><S><K><F><T><A><K><F><G><E><S><E><K><C><P><R><C><G><K><S><V><Y><A><A><E><K><V><M><G><G><G><K><P><W><H><K><T><C><F><R><C><A><I><C><G><K><S><L><E><S><T><N><V><T><D><K><D><G><E><L><Y><C><K><V><C><Y><A><K><N><F><G><P><T><G><I><G><F><G><G><L><T><Q><Q><V><E><K><K><E> | May play a role in early sarcomere organization. Overexpression in myotubes negatively regulates myotube differentiation. By association with isoform 1 and thus changing the CSRP3 isoform 1:CFL2 stoichiometry is proposed to down-regulate CFL2-mediated F-actin depolymerization.<BOP> | P50461 |
Q9NS93 | TM7S3_HUMAN | Seven span transmembrane protein | Homo | <M><G><F><L><Q><L><L><V><V><A><V><L><A><S><E><H><R><V><A><G><A><A><E><V><F><G><N><S><S><E><G><L><I><E><F><S><V><G><K><F><R><Y><F><E><L><N><R><P><F><P><E><E><A><I><L><H><D><I><S><S><N><V><T><F><L><I><F><Q><I><H><S><Q><Y><Q><N><T><T><V><S><F><S><P><T><L><L><S><N><S><S><E><T><G><T><A><S><G><L><V><F><I><L><R><P><E><Q><S><T><C><T><W><Y><L><G><T><S><G><I><Q><P><V><Q><N><M><A><I><L><L><S><Y><S><E><R><D><P><V><P><G><G><C><N><L><E><F><D><L><D><I><D><P><N><I><Y><L><E><Y><N><F><F><E><T><T><I><K><F><A><P><A><N><L><G><Y><A><R><G><V><D><P><P><P><C><D><A><G><T><D><Q><D><S><R><W><R><L><Q><Y><D><V><Y><Q><Y><F><L><P><E><N><D><L><T><E><E><M><L><L><K><H><L><Q><R><M><V><S><V><P><Q><V><K><A><S><A><L><K><V><V><T><L><T><A><N><D><K><T><S><V><S><F><S><S><L><P><G><Q><G><V><I><Y><N><V><I><V><W><D><P><F><L><N><T><S><A><A><Y><I><P><A><H><T><Y><A><C><S><F><E><A><G><E><G><S><C><A><S><L><G><R><V><S><S><K><V><F><F><T><L><F><A><L><L><G><F><F><I><C><F><F><G><H><R><F><W><K><T><E><L><F><F><I><G><F><I><I><M><G><F><F><F><Y><I><L><I><T><R><L><T><P><I><K><Y><D><V><N><L><I><L><T><A><V><T><G><S><V><G><G><M><F><L><V><A><V><W><W><R><F><G><I><L><S><I><C><M><L><C><V><G><L><V><L><G><F><L><I><S><S><V><T><F><F><T><P><L><G><N><L><K><I><F><H><D><D><G><V><F><W><V><T><F><S><C><I><A><I><L><I><P><V><V><F><M><G><C><L><R><I><L><N><I><L><T><C><G><V><I><G><S><Y><S><V><V><L><A><I><D><S><Y><W><S><T><S><L><S><Y><I><T><L><N><V><L><K><R><A><L><N><K><D><F><H><R><A><F><T><N><V><P><F><Q><T><N><D><F><I><I><L><A><V><W><G><M><L><A><V><S><G><I><T><L><Q><I><R><R><E><R><G><R><P><F><F><P><P><H><P><Y><K><L><W><K><Q><E><R><E><R><R><V><T><N><I><L><D><P><S><Y><H><I><P><P><L><R><E><R><L><Y><G><R><L><T><Q><I><K><G><L><F><Q><K><E><Q><P><A><G><E><R><T><P><L><L><L> | Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells . Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) .<BOP> | Q9NS93 |
P48506 | GSH1_HUMAN | Gamma-glutamylcysteine synthetase | Homo | <M><G><L><L><S><Q><G><S><P><L><S><W><E><E><T><K><R><H><A><D><H><V><R><R><H><G><I><L><Q><F><L><H><I><Y><H><A><V><K><D><R><H><K><D><V><L><K><W><G><D><E><V><E><Y><M><L><V><S><F><D><H><E><N><K><K><V><R><L><V><L><S><G><E><K><V><L><E><T><L><Q><E><K><G><E><R><T><N><P><N><H><P><T><L><W><R><P><E><Y><G><S><Y><M><I><E><G><T><P><G><Q><P><Y><G><G><T><M><S><E><F><N><T><V><E><A><N><M><R><K><R><R><K><E><A><T><S><I><L><E><E><N><Q><A><L><C><T><I><T><S><F><P><R><L><G><C><P><G><F><T><L><P><E><V><K><P><N><P><V><E><G><G><A><S><K><S><L><F><F><P><D><E><A><I><N><K><H><P><R><F><S><T><L><T><R><N><I><R><H><R><R><G><E><K><V><V><I><N><V><P><I><F><K><D><K><N><T><P><S><P><F><I><E><T><F><T><E><D><D><E><A><S><R><A><S><K><P><D><H><I><Y><M><D><A><M><G><F><G><M><G><N><C><C><L><Q><V><T><F><Q><A><C><S><I><S><E><A><R><Y><L><Y><D><Q><L><A><T><I><C><P><I><V><M><A><L><S><A><A><S><P><F><Y><R><G><Y><V><S><D><I><D><C><R><W><G><V><I><S><A><S><V><D><D><R><T><R><E><E><R><G><L><E><P><L><K><N><N><N><Y><R><I><S><K><S><R><Y><D><S><I><D><S><Y><L><S><K><C><G><E><K><Y><N><D><I><D><L><T><I><D><K><E><I><Y><E><Q><L><L><Q><E><G><I><D><H><L><L><A><Q><H><V><A><H><L><F><I><R><D><P><L><T><L><F><E><E><K><I><H><L><D><D><A><N><E><S><D><H><F><E><N><I><Q><S><T><N><W><Q><T><M><R><F><K><P><P><P><P><N><S><D><I><G><W><R><V><E><F><R><P><M><E><V><Q><L><T><D><F><E><N><S><A><Y><V><V><F><V><V><L><L><T><R><V><I><L><S><Y><K><L><D><F><L><I><P><L><S><K><V><D><E><N><M><K><V><A><Q><K><R><D><A><V><L><Q><G><M><F><Y><F><R><K><D><I><C><K><G><G><N><A><V><V><D><G><C><G><K><A><Q><N><S><T><E><L><A><A><E><E><Y><T><L><M><S><I><D><T><I><I><N><G><K><E><G><V><F><P><G><L><I><P><I><L><N><S><Y><L><E><N><M><E><V><D><V><D><T><R><C><S><I><L><N><Y><L><K><L><I><K><K><R><A><S><G><E><L><M><T><V><A><R><W><M><R><E><F><I><A><N><H><P><D><Y><K><Q><D><S><V><I><T><D><E><M><N><Y><S><L><I><L><K><C><N><Q><I><A><N><E><L><C><E><C><P><E><L><L><G><S><A><F><R><K><V><K><Y><S><G><S><K><T><D><S><S><N> | Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis.<BOP> | P48506 |
Q15126 | PMVK_HUMAN | Phosphomevalonate kinase | Homo | <M><A><P><L><G><G><A><P><R><L><V><L><L><F><S><G><K><R><K><S><G><K><D><F><V><T><E><A><L><Q><S><R><L><G><A><D><V><C><A><V><L><R><L><S><G><P><L><K><E><Q><Y><A><Q><E><H><G><L><N><F><Q><R><L><L><D><T><S><T><Y><K><E><A><F><R><K><D><M><I><R><W><G><E><E><K><R><Q><A><D><P><G><F><F><C><R><K><I><V><E><G><I><S><Q><P><I><W><L><V><S><D><T><R><R><V><S><D><I><Q><W><F><R><E><A><Y><G><A><V><T><Q><T><V><R><V><V><A><L><E><Q><S><R><Q><Q><R><G><W><V><F><T><P><G><V><D><D><A><E><S><E><C><G><L><D><N><F><G><D><F><D><W><V><I><E><N><H><G><V><E><Q><R><L><E><E><Q><L><E><N><L><I><E><F><I><R><S><R><L> | Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites.<BOP> | Q15126 |
P01876 | IGHA1_HUMAN | Ig alpha-1 chain C region TRO | Homo | <A><S><P><T><S><P><K><V><F><P><L><S><L><C><S><T><Q><P><D><G><N><V><V><I><A><C><L><V><Q><G><F><F><P><Q><E><P><L><S><V><T><W><S><E><S><G><Q><G><V><T><A><R><N><F><P><P><S><Q><D><A><S><G><D><L><Y><T><T><S><S><Q><L><T><L><P><A><T><Q><C><L><A><G><K><S><V><T><C><H><V><K><H><Y><T><N><P><S><Q><D><V><T><V><P><C><P><V><P><S><T><P><P><T><P><S><P><S><T><P><P><T><P><S><P><S><C><C><H><P><R><L><S><L><H><R><P><A><L><E><D><L><L><L><G><S><E><A><N><L><T><C><T><L><T><G><L><R><D><A><S><G><V><T><F><T><W><T><P><S><S><G><K><S><A><V><Q><G><P><P><E><R><D><L><C><G><C><Y><S><V><S><S><V><L><P><G><C><A><E><P><W><N><H><G><K><T><F><T><C><T><A><A><Y><P><E><S><K><T><P><L><T><A><T><L><S><K><S><G><N><T><F><R><P><E><V><H><L><L><P><P><P><S><E><E><L><A><L><N><E><L><V><T><L><T><C><L><A><R><G><F><S><P><K><D><V><L><V><R><W><L><Q><G><S><Q><E><L><P><R><E><K><Y><L><T><W><A><S><R><Q><E><P><S><Q><G><T><T><T><F><A><V><T><S><I><L><R><V><A><A><E><D><W><K><K><G><D><T><F><S><C><M><V><G><H><E><A><L><P><L><A><F><T><Q><K><T><I><D><R><L><A><G><K><P><T><H><V><N><V><S><V><V><M><A><E><V><D><G><T><C><Y> | Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen . Ig alpha is the major immunoglobulin class in body secretions .<BOP> | P01876 |
Q9HBI6 | CP4FB_HUMAN | Phylloquinone omega-hydroxylase CYP4F11 | Homo | <M><P><Q><L><S><L><S><W><L><G><L><G><P><V><A><A><S><P><W><L><L><L><L><L><V><G><G><S><W><L><L><A><R><V><L><A><W><T><Y><T><F><Y><D><N><C><R><R><L><Q><C><F><P><Q><P><P><K><Q><N><W><F><W><G><H><Q><G><L><V><T><P><T><E><E><G><M><K><T><L><T><Q><L><V><T><T><Y><P><Q><G><F><K><L><W><L><G><P><T><F><P><L><L><I><L><C><H><P><D><I><I><R><P><I><T><S><A><S><A><A><V><A><P><K><D><M><I><F><Y><G><F><L><K><P><W><L><G><D><G><L><L><L><S><G><G><D><K><W><S><R><H><R><R><M><L><T><P><A><F><H><F><N><I><L><K><P><Y><M><K><I><F><N><K><S><V><N><I><M><H><D><K><W><Q><R><L><A><S><E><G><S><A><R><L><D><M><F><E><H><I><S><L><M><T><L><D><S><L><Q><K><C><V><F><S><F><E><S><N><C><Q><E><K><P><S><E><Y><I><A><A><I><L><E><L><S><A><F><V><E><K><R><N><Q><Q><I><L><L><H><T><D><F><L><Y><Y><L><T><P><D><G><Q><R><F><R><R><A><C><H><L><V><H><D><F><T><D><A><V><I><Q><E><R><R><C><T><L><P><T><Q><G><I><D><D><F><L><K><N><K><A><K><S><K><T><L><D><F><I><D><V><L><L><L><S><K><D><E><D><G><K><E><L><S><D><E><D><I><R><A><E><A><D><T><F><M><F><E><G><H><D><T><T><A><S><G><L><S><W><V><L><Y><H><L><A><K><H><P><E><Y><Q><E><Q><C><R><Q><E><V><Q><E><L><L><K><D><R><E><P><I><E><I><E><W><D><D><L><A><Q><L><P><F><L><T><M><C><I><K><E><S><L><R><L><H><P><P><V><P><V><I><S><R><C><C><T><Q><D><F><V><L><P><D><G><R><V><I><P><K><G><I><V><C><L><I><N><I><I><G><I><H><Y><N><P><T><V><W><P><D><P><E><V><Y><D><P><F><R><F><D><Q><E><N><I><K><E><R><S><P><L><A><F><I><P><F><S><A><G><P><R><N><C><I><G><Q><A><F><A><M><A><E><M><K><V><V><L><A><L><T><L><L><H><F><R><I><L><P><T><H><T><E><P><R><R><K><P><E><L><I><L><R><A><E><G><G><L><W><L><R><V><E><P><L><G><A><N><S><Q> | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids . Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation . Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid | Q9HBI6 |
Q16581 | C3AR_HUMAN | C3a anaphylatoxin chemotactic receptor | Homo | <M><A><S><F><S><A><E><T><N><S><T><D><L><L><S><Q><P><W><N><E><P><P><V><I><L><S><M><V><I><L><S><L><T><F><L><L><G><L><P><G><N><G><L><V><L><W><V><A><G><L><K><M><Q><R><T><V><N><T><I><W><F><L><H><L><T><L><A><D><L><L><C><C><L><S><L><P><F><S><L><A><H><L><A><L><Q><G><Q><W><P><Y><G><R><F><L><C><K><L><I><P><S><I><I><V><L><N><M><F><A><S><V><F><L><L><T><A><I><S><L><D><R><C><L><V><V><F><K><P><I><W><C><Q><N><H><R><N><V><G><M><A><C><S><I><C><G><C><I><W><V><V><A><F><V><M><C><I><P><V><F><V><Y><R><E><I><F><T><T><D><N><H><N><R><C><G><Y><K><F><G><L><S><S><S><L><D><Y><P><D><F><Y><G><D><P><L><E><N><R><S><L><E><N><I><V><Q><P><P><G><E><M><N><D><R><L><D><P><S><S><F><Q><T><N><D><H><P><W><T><V><P><T><V><F><Q><P><Q><T><F><Q><R><P><S><A><D><S><L><P><R><G><S><A><R><L><T><S><Q><N><L><Y><S><N><V><F><K><P><A><D><V><V><S><P><K><I><P><S><G><F><P><I><E><D><H><E><T><S><P><L><D><N><S><D><A><F><L><S><T><H><L><K><L><F><P><S><A><S><S><N><S><F><Y><E><S><E><L><P><Q><G><F><Q><D><Y><Y><N><L><G><Q><F><T><D><D><D><Q><V><P><T><P><L><V><A><I><T><I><T><R><L><V><V><G><F><L><L><P><S><V><I><M><I><A><C><Y><S><F><I><V><F><R><M><Q><R><G><R><F><A><K><S><Q><S><K><T><F><R><V><A><V><V><V><V><A><V><F><L><V><C><W><T><P><Y><H><I><F><G><V><L><S><L><L><T><D><P><E><T><P><L><G><K><T><L><M><S><W><D><H><V><C><I><A><L><A><S><A><N><S><C><F><N><P><F><L><Y><A><L><L><G><K><D><F><R><K><K><A><R><Q><S><I><Q><G><I><L><E><A><A><F><S><E><E><L><T><R><S><T><H><C><P><S><N><N><V><I><S><E><R><N><S><T><T><V> | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.<BOP> | Q16581 |
P23490 | LORI_HUMAN | Loricrin | Homo | <M><S><Y><Q><K><K><Q><P><T><P><Q><P><P><V><D><C><V><K><T><S><G><G><G><G><G><G><G><G><S><G><G><G><G><C><G><F><F><G><G><G><G><S><G><G><G><S><S><G><S><G><C><G><Y><S><G><G><G><G><Y><S><G><G><G><C><G><G><G><S><S><G><G><G><G><G><G><G><I><G><G><C><G><G><G><S><G><G><S><V><K><Y><S><G><G><G><G><S><S><G><G><G><S><G><C><F><S><S><G><G><G><G><S><G><C><F><S><S><G><G><G><G><S><S><G><G><G><S><G><C><F><S><S><G><G><G><G><S><S><G><G><G><S><G><C><F><S><S><G><G><G><G><F><S><G><Q><A><V><Q><C><Q><S><Y><G><G><V><S><S><G><G><S><S><G><G><G><S><G><C><F><S><S><G><G><G><G><G><S><V><C><G><Y><S><G><G><G><S><G><C><G><G><G><S><S><G><G><S><G><S><G><Y><V><S><S><Q><Q><V><T><Q><T><S><C><A><P><Q><P><S><Y><G><G><G><S><S><G><G><G><G><S><G><G><S><G><C><F><S><S><G><G><G><G><G><S><S><G><C><G><G><G><S><S><G><I><G><S><G><C><I><I><S><G><G><G><S><V><C><G><G><G><S><S><G><G><G><G><G><G><S><S><V><G><G><S><G><S><G><K><G><V><P><I><C><H><Q><T><Q><Q><K><Q><A><P><T><W><P><S><K> | Major keratinocyte cell envelope protein.<BOP> | P23490 |
P49137 | MAPK2_HUMAN | MAP kinase-activated protein kinase 2 | Homo | <M><L><S><N><S><Q><G><Q><S><P><P><V><P><F><P><A><P><A><P><P><P><Q><P><P><T><P><A><L><P><H><P><P><A><Q><P><P><P><P><P><P><Q><Q><F><P><Q><F><H><V><K><S><G><L><Q><I><K><K><N><A><I><I><D><D><Y><K><V><T><S><Q><V><L><G><L><G><I><N><G><K><V><L><Q><I><F><N><K><R><T><Q><E><K><F><A><L><K><M><L><Q><D><C><P><K><A><R><R><E><V><E><L><H><W><R><A><S><Q><C><P><H><I><V><R><I><V><D><V><Y><E><N><L><Y><A><G><R><K><C><L><L><I><V><M><E><C><L><D><G><G><E><L><F><S><R><I><Q><D><R><G><D><Q><A><F><T><E><R><E><A><S><E><I><M><K><S><I><G><E><A><I><Q><Y><L><H><S><I><N><I><A><H><R><D><V><K><P><E><N><L><L><Y><T><S><K><R><P><N><A><I><L><K><L><T><D><F><G><F><A><K><E><T><T><S><H><N><S><L><T><T><P><C><Y><T><P><Y><Y><V><A><P><E><V><L><G><P><E><K><Y><D><K><S><C><D><M><W><S><L><G><V><I><M><Y><I><L><L><C><G><Y><P><P><F><Y><S><N><H><G><L><A><I><S><P><G><M><K><T><R><I><R><M><G><Q><Y><E><F><P><N><P><E><W><S><E><V><S><E><E><V><K><M><L><I><R><N><L><L><K><T><E><P><T><Q><R><M><T><I><T><E><F><M><N><H><P><W><I><M><Q><S><T><K><V><P><Q><T><P><L><H><T><S><R><V><L><K><E><D><K><E><R><W><E><D><V><K><E><E><M><T><S><A><L><A><T><M><R><V><D><Y><E><Q><I><K><I><K><K><I><E><D><A><S><N><P><L><L><L><K><R><R><K><K><A><R><A><L><E><A><A><A><L><A><H> | Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities . Mediates phosphorylation of HSP27/HSP | P49137 |
Q6Y1H2 | HACD2_HUMAN | Protein-tyrosine phosphatase-like member B | Homo | <M><A><A><V><A><A><T><A><A><A><K><G><N><G><G><G><G><G><R><A><G><A><G><D><A><S><G><T><R><K><K><K><G><P><G><P><L><A><T><A><Y><L><V><I><Y><N><V><V><M><T><A><G><W><L><V><I><A><V><G><L><V><R><A><Y><L><A><K><G><S><Y><H><S><L><Y><Y><S><I><E><K><P><L><K><F><F><Q><T><G><A><L><L><E><I><L><H><C><A><I><G><I><V><P><S><S><V><V><L><T><S><F><Q><V><M><S><R><V><F><L><I><W><A><V><T><H><S><V><K><E><V><Q><S><E><D><S><V><L><L><F><V><I><A><W><T><I><T><E><I><I><R><Y><S><F><Y><T><F><S><L><L><N><H><L><P><Y><L><I><K><W><A><R><Y><T><L><F><I><V><L><Y><P><M><G><V><S><G><E><L><L><T><I><Y><A><A><L><P><F><V><R><Q><A><G><L><Y><S><I><S><L><P><N><K><Y><N><F><S><F><D><Y><Y><A><F><L><I><L><I><M><I><S><Y><I><P><I><F><P><Q><L><Y><F><H><M><I><H><Q><R><R><K><I><L><S><H><T><E><E><H><K><K><F><E> | Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation. Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators.<BOP> | Q6Y1H2 |
A0A0C4DH43 | HV70D_HUMAN | Immunoglobulin heavy variable 2-70D | Homo | <M><D><I><L><C><S><T><L><L><L><L><T><V><P><S><W><V><L><S><Q><V><T><L><K><E><S><G><P><A><L><V><K><P><T><Q><T><L><T><L><T><C><T><F><S><G><F><S><L><S><T><S><G><M><R><V><S><W><I><R><Q><P><P><G><K><A><L><E><W><L><A><R><I><D><W><D><D><D><K><F><Y><S><T><S><L><K><T><R><L><T><I><S><K><D><T><S><K><N><Q><V><V><L><T><M><T><N><M><D><P><V><D><T><A><T><Y><Y><C><A><R><I> | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | A0A0C4DH43 |
Q9H1J1 | REN3A_HUMAN | Up-frameshift suppressor 3 homolog A | Homo | <M><R><S><E><K><E><G><A><G><G><L><R><A><A><V><A><A><R><G><P><S><G><R><E><K><L><S><A><L><E><V><Q><F><H><R><D><S><Q><Q><Q><E><A><E><T><P><P><T><S><S><S><G><C><G><G><G><A><G><K><P><R><E><E><K><R><T><A><L><S><K><V><V><I><R><R><L><P><P><G><L><T><K><E><Q><L><E><E><Q><L><R><P><L><P><A><H><D><Y><F><E><F><F><A><A><D><L><S><L><Y><P><H><L><Y><S><R><A><Y><I><N><F><R><N><P><D><D><I><L><L><F><R><D><R><F><D><G><Y><I><F><L><D><S><K><G><L><E><Y><P><A><V><V><E><F><A><P><F><Q><K><I><A><K><K><K><L><R><K><K><D><A><K><T><G><S><I><E><D><D><P><E><Y><K><K><F><L><E><T><Y><C><V><E><E><E><K><T><S><A><N><P><E><T><L><L><G><E><M><E><A><K><T><R><E><L><I><A><R><R><T><T><P><L><L><E><Y><I><K><N><R><K><L><E><K><Q><R><I><R><E><E><K><R><E><E><R><R><R><R><E><L><E><K><K><R><L><R><E><E><E><K><R><R><R><R><E><E><E><R><C><K><K><K><E><T><D><K><Q><K><K><I><A><E><K><E><V><R><I><K><L><L><K><K><P><E><K><G><E><E><P><T><T><E><K><P><K><E><R><G><E><E><I><D><T><G><G><G><K><Q><E><S><C><A><P><G><A><V><V><K><A><R><P><M><E><G><S><L><E><E><P><Q><E><T><S><H><S><G><S><D><K><E><H><R><D><V><E><R><S><Q><E><Q><E><S><E><A><Q><R><Y><H><V><D><D><G><R><R><H><R><A><H><H><E><P><E><R><L><S><R><R><S><E><D><E><Q><R><W><G><K><G><P><G><Q><D><R><G><K><K><G><S><Q><D><S><G><A><P><G><E><A><M><E><R><L><G><R><A><Q><R><C><D><D><S><P><A><P><R><K><E><R><L><A><N><K><D><R><P><A><L><Q><L><Y><D><P><G><A><R><F><R><A><R><E><C><G><G><N><R><R><I><C><K><A><E><G><S><G><T><G><P><E><K><R><E><E><A><E> | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.<BOP> | Q9H1J1 |
A6NFA1 | TIKI2_HUMAN | TRAB domain-containing protein 2B | Homo | <M><H><A><A><L><A><G><P><L><L><A><A><L><L><A><T><A><R><A><R><P><Q><P><P><D><G><G><Q><C><R><P><P><G><S><Q><R><D><L><N><S><F><L><W><T><I><R><R><D><P><P><A><Y><L><F><G><T><I><H><V><P><Y><T><R><V><W><D><F><I><P><D><N><S><K><A><A><F><Q><A><S><T><R><V><Y><F><E><L><D><L><T><D><P><Y><T><I><S><A><L><A><S><C><Q><L><L><P><H><G><E><N><L><Q><D><V><L><P><H><E><L><Y><W><R><L><K><R><H><L><D><Y><V><K><L><M><M><P><S><W><M><T><P><A><Q><R><G><K><G><L><Y><A><D><Y><L><F><N><A><I><A><G><N><W><E><R><K><R><P><V><W><V><M><L><M><V><N><S><L><T><E><R><D><V><R><F><R><G><V><P><V><L><D><L><Y><L><A><Q><Q><A><E><K><M><K><K><T><T><G><A><V><E><Q><V><E><E><Q><C><H><P><L><N><N><G><L><N><F><S><Q><V><L><F><A><L><N><Q><T><L><L><Q><Q><E><S><V><R><A><G><S><L><Q><A><S><Y><T><T><E><D><L><I><K><H><Y><N><C><G><D><L><S><A><V><I><F><N><H><D><T><S><Q><L><P><N><F><I><N><T><T><L><P><P><H><E><Q><V><T><A><Q><E><I><D><S><Y><F><R><Q><E><L><I><Y><K><R><N><E><R><M><G><K><R><V><M><A><L><L><R><E><N><E><D><K><I><C><F><F><A><F><G><A><G><H><F><L><G><N><N><T><V><I><D><I><L><R><Q><A><G><L><E><V><D><H><T><P><A><G><Q><A><I><H><S><P><A><P><Q><S><P><A><P><S><P><E><G><T><S><T><S><P><A><P><V><T><P><A><A><A><V><P><E><A><P><S><V><T><P><T><A><P><P><E><D><E><D><P><A><L><S><P><H><L><L><L><P><D><S><L><S><Q><L><E><E><F><G><R><Q><R><K><W><H><K><R><Q><S><T><H><Q><R><P><R><Q><F><N><D><L><W><V><R><I><E><D><S><T><T><A><S><P><P><P><L><P><L><Q><P><T><H><S><S><G><T><A><K><P><P><F><Q><L><S><D><Q><L><Q><Q><Q><D><P><P><G><P><A><S><S><S><A><P><T><L><G><L><L><P><A><I><A><T><T><I><A><V><C><F><L><L><H><S><L><G><P><S> | Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.<BOP> | A6NFA1 |
P49146 | NPY2R_HUMAN | NPY-Y2 receptor | Homo | <M><G><P><I><G><A><E><A><D><E><N><Q><T><V><E><E><M><K><V><E><Q><Y><G><P><Q><T><T><P><R><G><E><L><V><P><D><P><E><P><E><L><I><D><S><T><K><L><I><E><V><Q><V><V><L><I><L><A><Y><C><S><I><I><L><L><G><V><I><G><N><S><L><V><I><H><V><V><I><K><F><K><S><M><R><T><V><T><N><F><F><I><A><N><L><A><V><A><D><L><L><V><N><T><L><C><L><P><F><T><L><T><Y><T><L><M><G><E><W><K><M><G><P><V><L><C><H><L><V><P><Y><A><Q><G><L><A><V><Q><V><S><T><I><T><L><T><V><I><A><L><D><R><H><R><C><I><V><Y><H><L><E><S><K><I><S><K><R><I><S><F><L><I><I><G><L><A><W><G><I><S><A><L><L><A><S><P><L><A><I><F><R><E><Y><S><L><I><E><I><I><P><D><F><E><I><V><A><C><T><E><K><W><P><G><E><E><K><S><I><Y><G><T><V><Y><S><L><S><S><L><L><I><L><Y><V><L><P><L><G><I><I><S><F><S><Y><T><R><I><W><S><K><L><K><N><H><V><S><P><G><A><A><N><D><H><Y><H><Q><R><R><Q><K><T><T><K><M><L><V><C><V><V><V><V><F><A><V><S><W><L><P><L><H><A><F><Q><L><A><V><D><I><D><S><Q><V><L><D><L><K><E><Y><K><L><I><F><T><V><F><H><I><I><A><M><C><S><T><F><A><N><P><L><L><Y><G><W><M><N><S><N><Y><R><K><A><F><L><S><A><F><R><C><E><Q><R><L><D><A><I><H><S><E><V><S><V><T><F><K><A><K><K><N><L><E><V><R><K><N><S><G><P><N><D><S><F><T><E><A><T><N><V> | Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.<BOP> | P49146 |
Q9NZV7 | ZIM2_HUMAN | Zinc finger protein 656 | Homo | <M><Y><Q><P><E><D><D><N><N><S><D><V><T><S><D><D><D><M><T><R><N><R><R><E><S><S><P><P><H><S><V><H><S><F><S><G><D><R><D><W><D><R><R><G><R><S><R><D><M><E><P><R><D><R><W><S><H><T><R><N><P><R><S><R><M><P><P><R><D><L><S><L><P><V><V><A><K><T><S><F><E><M><D><R><E><D><D><R><D><S><R><A><Y><E><S><R><S><Q><D><A><E><S><Y><Q><N><V><V><D><L><A><E><D><R><K><P><H><N><T><I><Q><D><N><M><E><N><Y><R><K><L><L><S><L><G><F><L><A><Q><D><S><V><P><A><E><K><R><N><T><E><M><L><D><N><L><P><S><A><G><S><Q><F><P><D><F><K><H><L><G><T><F><L><V><F><E><E><L><V><T><F><E><D><V><L><V><D><F><S><P><E><E><L><S><S><L><S><A><A><Q><R><N><L><Y><R><E><V><M><L><E><N><Y><R><N><L><V><S><L><G><H><Q><F><S><K><P><D><I><I><S><R><L><E><E><E><E><S><Y><A><M><E><T><D><S><R><H><T><V><I><C><Q><G><E><S><H><D><D><P><L><E><P><H><Q><G><N><Q><E><K><L><L><T><P><I><T><M><N><D><P><K><T><L><T><P><E><R><S><Y><G><S><D><E><F><E><R><S><S><N><L><S><K><Q><S><K><D><P><L><G><K><D><P><Q><E><G><T><A><P><G><I><C><T><S><P><Q><S><A><S><Q><E><N><K><H><N><R><C><E><F><C><K><R><T><F><S><T><Q><V><A><L><R><R><H><E><R><I><H><T><G><K><K><P><Y><E><C><K><Q><C><A><E><A><F><Y><L><M><P><H><L><N><R><H><Q><K><T><H><S><G><R><K><T><S><G><C><N><E><G><R><K><P><S><V><Q><C><A><N><L><C><E><R><V><R><I><H><S><Q><E><D><Y><F><E><C><F><Q><C><G><K><A><F><L><Q><N><V><H><L><L><Q><H><L><K><A><H><E><A><A><R><V><L><P><P><G><L><S><H><S><K><T><Y><L><I><R><Y><Q><R><K><H><D><Y><V><G><E><R><A><C><Q><C><C><D><C><G><R><V><F><S><R><N><S><Y><L><I><Q><H><Y><R><T><H><T><Q><E><R><P><Y><Q><C><Q><L><C><G><K><C><F><G><R><P><S><Y><L><T><Q><H><Y><Q><L><H><S><Q><E><K><T><V><E><C><D><H><C> | May be involved in transcriptional regulation.<BOP> | Q9NZV7 |
A0A0K0K1A3 | TVBJ1_HUMAN | T cell receptor beta variable 10-1 | Homo | <M><G><T><R><L><F><F><Y><V><A><L><C><L><L><W><A><G><H><R><D><A><E><I><T><Q><S><P><R><H><K><I><T><E><T><G><R><Q><V><T><L><A><C><H><Q><T><W><N><H><N><N><M><F><W><Y><R><Q><D><L><G><H><G><L><R><L><I><H><Y><S><Y><G><V><H><D><T><N><K><G><E><V><S><D><G><Y><S><V><S><R><S><N><T><E><D><L><P><L><T><L><E><S><A><A><S><S><Q><T><S><V><Y><F><C><A><S><S><E> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0K0K1A3 |
Q9BYQ8 | KRA49_HUMAN | Ultrahigh sulfur keratin-associated protein 4.9 | Homo | <M><V><S><S><C><C><G><S><V><C><S><D><Q><G><C><G><Q><D><L><C><Q><E><T><C><C><R><P><S><C><C><E><T><T><C><C><R><T><T><C><C><R><P><S><C><C><V><S><S><C><C><R><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><S><R><P><S><C><C><Q><T><T><C><C><R><T><T><C><Y><R><P><S><C><C><V><S><S><C><C><R><P><Q><C><C><Q><P><A><C><C><Q><P><T><C><C><R><P><S><C><C><E><T><T><C><C><H><P><R><C><C><I><S><S><C><C><R><P><S><C><C><V><S><S><C><C><K><P><Q><C><C><Q><S><V><C><C><Q><P><N><C><C><R><P><S><C><S><I><S><S><C><C><R><P><S><C><C><E><S><S><C><C><R><P><C><C><C><V><R><P><V><C><G><R><V><S><C><H><T><T><C><Y><R><P><T><C><V><I><S><S><C><P><R><P><L><C><C><A><S><S><C><C> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | Q9BYQ8 |
Q6ZSS3 | ZN621_HUMAN | Zinc finger protein 621 | Homo | <M><L><Q><T><T><W><P><Q><E><S><V><T><F><E><D><V><A><V><Y><F><T><Q><N><Q><W><A><S><L><D><P><A><Q><R><A><L><Y><G><E><V><M><L><E><N><Y><A><N><V><A><S><L><V><A><F><P><F><P><K><P><A><L><I><S><H><L><E><R><G><E><A><P><W><G><P><D><P><W><D><T><E><I><L><R><G><I><S><Q><G><G><E><S><W><I><K><N><E><G><L><V><I><K><Q><E><A><S><E><E><T><E><L><H><R><M><P><V><G><G><L><L><R><N><V><S><Q><H><F><D><F><K><R><K><A><L><K><Q><T><F><N><L><N><P><N><L><I><L><R><G><G><M><K><F><Y><E><C><K><E><C><G><K><I><F><R><Y><N><S><K><L><I><R><H><Q><M><S><H><T><G><E><K><P><F><K><C><K><E><C><G><K><A><F><K><S><S><Y><D><C><I><V><H><E><K><N><H><I><G><E><G><P><Y><E><C><K><E><C><G><K><G><L><S><S><N><T><A><L><T><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><R><S><A><A><Y><L><Q><H><Q><R><L><H><T><G><E><K><L><Y><K><C><K><E><C><W><K><A><F><G><C><R><S><L><F><I><V><H><Q><R><I><H><T><G><E><K><P><Y><Q><C><K><E><C><G><K><A><F><T><Q><K><I><A><S><I><Q><H><Q><R><V><H><T><G><E><K><P><Y><E><C><K><V><C><G><K><A><F><K><W><Y><G><S><F><V><Q><H><Q><K><L><H><P><V><E><K><K><P><V><K><V><L><G><P><S><L><V><S><P><Q><C><S><S><P><A><I><P><P><V><L><L><Q><G><S><C><S><A><S><A><V><A><V><P><S><L><T><F><P><H><A><V><L><I><P><T><S><G><N><F><F><M><L><L><P><T><S><G><I><P><S><S><S><A><Q><I><V><R><V><F><Q><G><L><T><P><T><V><K><P><S><P><V><I><L><T><P><S><S><H><S><S> | May be involved in transcriptional regulation.<BOP> | Q6ZSS3 |
Q9HB55 | CP343_HUMAN | Cytochrome P450 3A43 | Homo | <M><D><L><I><P><N><F><A><M><E><T><W><V><L><V><A><T><S><L><V><L><L><Y><I><Y><G><T><H><S><H><K><L><F><K><K><L><G><I><P><G><P><T><P><L><P><F><L><G><T><I><L><F><Y><L><R><G><L><W><N><F><D><R><E><C><N><E><K><Y><G><E><M><W><G><L><Y><E><G><Q><Q><P><M><L><V><I><M><D><P><D><M><I><K><T><V><L><V><K><E><C><Y><S><V><F><T><N><Q><M><P><L><G><P><M><G><F><L><K><S><A><L><S><F><A><E><D><E><E><W><K><R><I><R><T><L><L><S><P><A><F><T><S><V><K><F><K><E><M><V><P><I><I><S><Q><C><G><D><M><L><V><R><S><L><R><Q><E><A><E><N><S><K><S><I><N><L><K><D><F><F><G><A><Y><T><M><D><V><I><T><G><T><L><F><G><V><N><L><D><S><L><N><N><P><Q><D><P><F><L><K><N><M><K><K><L><L><K><L><D><F><L><D><P><F><L><L><L><I><S><L><F><P><F><L><T><P><V><F><E><A><L><N><I><G><L><F><P><K><D><V><T><H><F><L><K><N><S><I><E><R><M><K><E><S><R><L><K><D><K><Q><K><H><R><V><D><F><F><Q><Q><M><I><D><S><Q><N><S><K><E><T><K><S><H><K><A><L><S><D><L><E><L><V><A><Q><S><I><I><I><I><F><A><A><Y><D><T><T><S><T><T><L><P><F><I><M><Y><E><L><A><T><H><P><D><V><Q><Q><K><L><Q><E><E><I><D><A><V><L><P><N><K><A><P><V><T><Y><D><A><L><V><Q><M><E><Y><L><D><M><V><V><N><E><T><L><R><L><F><P><V><V><S><R><V><T><R><V><C><K><K><D><I><E><I><N><G><V><F><I><P><K><G><L><A><V><M><V><P><I><Y><A><L><H><H><D><P><K><Y><W><T><E><P><E><K><F><C><P><E><R><F><S><K><K><N><K><D><S><I><D><L><Y><R><Y><I><P><F><G><A><G><P><R><N><C><I><G><M><R><F><A><L><T><N><I><K><L><A><V><I><R><A><L><Q><N><F><S><F><K><P><C><K><E><T><Q><I><P><L><K><L><D><N><L><P><I><L><Q><P><E><K><P><I><V><L><K><V><H><L><R><D><G><I><T><S><G><P> | Exhibits low testosterone 6-beta-hydroxylase activity.<BOP> | Q9HB55 |
Q8NGJ7 | O51A2_HUMAN | Olfactory receptor 51A2 | Homo | <M><S><I><I><N><T><S><Y><V><E><I><T><T><F><F><L><V><G><M><P><G><L><E><Y><A><H><I><W><I><S><I><P><I><C><S><M><Y><L><I><A><I><L><G><N><G><T><I><L><F><I><I><K><T><E><P><S><L><H><G><P><M><Y><Y><F><L><S><M><L><A><M><S><D><L><G><L><S><L><S><S><L><P><T><V><L><S><I><F><L><F><N><A><P><E><T><S><S><S><A><C><F><A><Q><E><F><F><I><H><G><F><S><V><L><E><S><S><V><L><L><I><M><S><F><D><R><F><L><A><I><H><N><P><L><R><Y><T><S><I><L><T><T><V><R><V><A><Q><I><G><I><V><F><S><F><K><S><M><L><L><V><L><P><F><P><F><T><L><R><S><L><R><Y><C><K><K><N><Q><L><S><H><S><Y><C><L><H><Q><D><V><M><K><L><A><C><S><D><N><R><I><D><V><I><Y><G><F><F><G><A><L><C><L><M><V><D><F><I><L><I><A><V><S><Y><T><L><I><L><K><T><V><P><G><I><A><S><K><K><E><E><L><K><A><L><N><T><C><V><S><H><I><C><A><V><I><I><F><Y><L><P><I><I><N><L><A><V><V><H><R><F><A><G><H><V><S><P><L><I><N><V><L><M><A><N><V><L><L><L><V><P><P><L><M><K><P><I><V><Y><C><V><K><T><K><Q><I><R><V><R><V><V><A><K><L><C><Q><W><K><I> | Odorant receptor.<BOP> | Q8NGJ7 |
Q9H8H3 | MET7A_HUMAN | Protein AAM-B | Homo | <M><E><L><T><I><F><I><L><R><L><A><I><Y><I><L><T><F><P><L><Y><L><L><N><F><L><G><L><W><S><W><I><C><K><K><W><F><P><Y><F><L><V><R><F><T><V><I><Y><N><E><Q><M><A><S><K><K><R><E><L><F><S><N><L><Q><E><F><A><G><P><S><G><K><L><S><L><L><E><V><G><C><G><T><G><A><N><F><K><F><Y><P><P><G><C><R><V><T><C><I><D><P><N><P><N><F><E><K><F><L><I><K><S><I><A><E><N><R><H><L><Q><F><E><R><F><V><V><A><A><G><E><N><M><H><Q><V><A><D><G><S><V><D><V><V><V><C><T><L><V><L><C><S><V><K><N><Q><E><R><I><L><R><E><V><C><R><V><L><R><P><G><G><A><F><Y><F><M><E><H><V><A><A><E><C><S><T><W><N><Y><F><W><Q><Q><V><L><D><P><A><W><H><L><L><F><D><G><C><N><L><T><R><E><S><W><K><A><L><E><R><A><S><F><S><K><L><K><L><Q><H><I><Q><A><P><L><S><W><E><L><V><R><P><H><I><Y><G><Y><A><V><K> | (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation.<BOP> | Q9H8H3 |
P63122 | VPK8_HUMAN | Proteinase | Homo | <W><A><S><Q><V><S><E><N><R><P><V><C><K><A><I><I><Q><G><K><Q><F><E><G><L><V><D><T><G><A><D><V><S><I><I><A><L><N><Q><W><P><K><N><W><P><K><Q><K><A><V><I><G><L><V><G><I><G><T><A><S><E><V><Y><Q><S><M><E><I><L><H><C><L><G><P><D><N><Q><E><S><T><V><Q><P><M><I><T><S><I><P><L><N><L><W><G><R><D><L><L><Q><Q><W><G><A><E><I><T><M><P><A><P><L><Y><S><P><T><S><Q><K><I><M><T><K><R><G><Y><I><P><G><K><G><L><G><K><N><E><D><G><I><K><I><P><F><E><A><K><I><N><Q><K><R><E><G><I><G><Y><P><F> | Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.<BOP> | P63122 |
P28325 | CYTD_HUMAN | Cystatin-5 | Homo | <M><M><W><P><M><H><T><P><L><L><L><L><T><A><L><M><V><A><V><A><G><S><A><S><A><Q><S><R><T><L><A><G><G><I><H><A><T><D><L><N><D><K><S><V><Q><C><A><L><D><F><A><I><S><E><Y><N><K><V><I><N><K><D><E><Y><Y><S><R><P><L><Q><V><M><A><A><Y><Q><Q><I><V><G><G><V><N><Y><Y><F><N><V><K><F><G><R><T><T><C><T><K><S><Q><P><N><L><D><N><C><P><F><N><D><Q><P><K><L><K><E><E><E><F><C><S><F><Q><I><N><E><V><P><W><E><D><K><I><S><I><L><N><Y><K><C><R><K><V> | Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.<BOP> | P28325 |
A8MZ59 | LEUTX_HUMAN | Paired-like homeobox transcription factor LEUTX | Homo | <M><F><E><G><P><R><R><Y><R><R><P><R><T><R><F><L><S><K><Q><L><T><A><L><R><E><L><L><E><K><T><M><H><P><S><L><A><T><M><G><K><L><A><S><K><L><Q><L><D><L><S><V><V><K><I><W><F><K><N><Q><R><A><K><W><K><R><Q><Q><R><Q><Q><M><Q><T><R><P><S><L><G><P><A><N><Q><T><T><S><V><K><K><E><E><T><P><S><A><I><T><T><A><N><I><R><P><V><S><P><G><I><S><D><A><N><D><H><D><L><R><E><P><S><G><I><K><N><P><G><G><A><S><A><S><A><R><V><S><S><W><D><S><Q><S><Y><D><I><E><Q><I><C><L><G><A><S><N><P><P><W><A><S><T><L><F><E><I><D><E><F><V><K><I><Y><D><L><P><G><E><D><D><T><S><S><L><N><Q><Y><L><F><P><V><C><L><E><Y><D><Q><L><Q><S><S><V> | Inactive transcriptional activity.<BOP> | A8MZ59 |
P37108 | SRP14_HUMAN | 18 kDa Alu RNA-binding protein | Homo | <M><V><L><L><E><S><E><Q><F><L><T><E><L><T><R><L><F><Q><K><C><R><T><S><G><S><V><Y><I><T><L><K><K><Y><D><G><R><T><K><P><I><P><K><K><G><T><V><E><G><F><E><P><A><D><N><K><C><L><L><R><A><T><D><G><K><K><K><I><S><T><V><V><S><S><K><E><V><N><K><F><Q><M><A><Y><S><N><L><L><R><A><N><M><D><G><L><K><K><R><D><K><K><N><K><T><K><K><T><K><A><A><A><A><A><A><A><A><A><P><A><A><A><A><T><A><P><T><T><A><A><T><T><A><A><T><A><A><Q> | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) . SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP . The complex of SRP9 and SRP14 is required for SRP RNA binding .<BOP> | P37108 |
Q9Y251 | HPSE_HUMAN | Heparanase 50 kDa subunit | Homo | <M><L><L><R><S><K><P><A><L><P><P><P><L><M><L><L><L><L><G><P><L><G><P><L><S><P><G><A><L><P><R><P><A><Q><A><Q><D><V><V><D><L><D><F><F><T><Q><E><P><L><H><L><V><S><P><S><F><L><S><V><T><I><D><A><N><L><A><T><D><P><R><F><L><I><L><L><G><S><P><K><L><R><T><L><A><R><G><L><S><P><A><Y><L><R><F><G><G><T><K><T><D><F><L><I><F><D><P><K><K><E><S><T><F><E><E><R><S><Y><W><Q><S><Q><V><N><Q><D><I><C><K><Y><G><S><I><P><P><D><V><E><E><K><L><R><L><E><W><P><Y><Q><E><Q><L><L><L><R><E><H><Y><Q><K><K><F><K><N><S><T><Y><S><R><S><S><V><D><V><L><Y><T><F><A><N><C><S><G><L><D><L><I><F><G><L><N><A><L><L><R><T><A><D><L><Q><W><N><S><S><N><A><Q><L><L><L><D><Y><C><S><S><K><G><Y><N><I><S><W><E><L><G><N><E><P><N><S><F><L><K><K><A><D><I><F><I><N><G><S><Q><L><G><E><D><F><I><Q><L><H><K><L><L><R><K><S><T><F><K><N><A><K><L><Y><G><P><D><V><G><Q><P><R><R><K><T><A><K><M><L><K><S><F><L><K><A><G><G><E><V><I><D><S><V><T><W><H><H><Y><Y><L><N><G><R><T><A><T><K><E><D><F><L><N><P><D><V><L><D><I><F><I><S><S><V><Q><K><V><F><Q><V><V><E><S><T><R><P><G><K><K><V><W><L><G><E><T><S><S><A><Y><G><G><G><A><P><L><L><S><D><T><F><A><A><G><F><M><W><L><D><K><L><G><L><S><A><R><M><G><I><E><V><V><M><R><Q><V><F><F><G><A><G><N><Y><H><L><V><D><E><N><F><D><P><L><P><D><Y><W><L><S><L><L><F><K><K><L><V><G><T><K><V><L><M><A><S><V><Q><G><S><K><R><R><K><L><R><V><Y><L><H><C><T><N><T><D><N><P><R><Y><K><E><G><D><L><T><L><Y><A><I><N><L><H><N><V><T><K><Y><L><R><L><P><Y><P><F><S><N><K><Q><V><D><K><Y><L><L><R><P><L><G><P><H><G><L><L><S><K><S><V><Q><L><N><G><L><T><L><K><M><V><D><D><Q><T><L><P><P><L><M><E><K><P><L><R><P><G><S><S><L><G><L><P><A><F><S><Y><S><F><F><V><I><R><N><A><K><V><A><A><C><I> | Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity | Q9Y251 |
Q8NGF6 | O10W1_HUMAN | Olfactory receptor OR11-236 | Homo | <M><E><F><V><F><L><A><Y><P><S><C><P><E><L><H><I><L><S><F><L><G><V><S><L><V><Y><G><L><I><I><T><G><N><I><L><I><V><V><S><I><H><T><E><T><C><L><C><T><S><M><Y><Y><F><L><G><S><L><S><G><I><E><I><C><Y><T><A><V><V><V><P><H><I><L><A><N><T><L><Q><S><E><K><T><I><T><L><L><G><C><A><T><Q><M><A><F><F><I><A><L><G><S><A><D><C><F><L><L><A><A><M><A><Y><D><R><Y><V><A><I><C><H><P><L><Q><Y><P><L><L><M><T><L><T><L><C><V><H><L><V><V><A><S><V><I><S><G><L><F><L><S><L><Q><L><V><A><F><I><F><S><L><P><F><C><Q><A><Q><G><I><E><H><F><F><C><D><V><P><P><V><M><H><V><V><C><A><Q><S><H><I><H><E><Q><S><V><L><V><A><A><I><L><A><I><A><V><P><F><F><L><I><T><T><S><Y><T><F><I><V><A><A><L><L><K><I><H><S><A><A><G><R><H><R><A><F><S><T><C><S><S><H><L><T><V><V><L><L><Q><Y><G><C><C><A><F><M><Y><L><C><P><S><S><S><Y><N><P><K><Q><D><R><F><I><S><L><V><Y><T><L><G><T><P><L><L><N><P><L><I><Y><A><L><R><N><S><E><M><K><G><A><V><G><R><V><L><T><R><N><C><L><S><Q><N><S> | Odorant receptor.<BOP> | Q8NGF6 |
Q93096 | TP4A1_HUMAN | Protein-tyrosine phosphatase of regenerating liver 1 | Homo | <M><A><R><M><N><R><P><A><P><V><E><V><T><Y><K><N><M><R><F><L><I><T><H><N><P><T><N><A><T><L><N><K><F><I><E><E><L><K><K><Y><G><V><T><T><I><V><R><V><C><E><A><T><Y><D><T><T><L><V><E><K><E><G><I><H><V><L><D><W><P><F><D><D><G><A><P><P><S><N><Q><I><V><D><D><W><L><S><L><V><K><I><K><F><R><E><E><P><G><C><C><I><A><V><H><C><V><A><G><L><G><R><A><P><V><L><V><A><L><A><L><I><E><G><G><M><K><Y><E><D><A><V><Q><F><I><R><Q><K><R><R><G><A><F><N><S><K><Q><L><L><Y><L><E><K><Y><R><P><K><M><R><L><R><F><K><D><S><N><G><H><R><N><N><C><C><I><Q> | Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.<BOP> | Q93096 |
P47944 | MT4_HUMAN | Metallothionein-IV | Homo | <M><D><P><R><E><C><V><C><M><S><G><G><I><C><M><C><G><D><N><C><K><C><T><T><C><N><C><K><T><Y><W><K><S><C><C><P><C><C><P><P><G><C><A><K><C><A><R><G><C><I><C><K><G><G><S><D><K><C><S><C><C><P> | Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.<BOP> | P47944 |
P36404 | ARL2_HUMAN | ADP-ribosylation factor-like protein 2 | Homo | <M><G><L><L><T><I><L><K><K><M><K><Q><K><E><R><E><L><R><L><L><M><L><G><L><D><N><A><G><K><T><T><I><L><K><K><F><N><G><E><D><I><D><T><I><S><P><T><L><G><F><N><I><K><T><L><E><H><R><G><F><K><L><N><I><W><D><V><G><G><Q><K><S><L><R><S><Y><W><R><N><Y><F><E><S><T><D><G><L><I><W><V><V><D><S><A><D><R><Q><R><M><Q><D><C><Q><R><E><L><Q><S><L><L><V><E><E><R><L><A><G><A><T><L><L><I><F><A><N><K><Q><D><L><P><G><A><L><S><S><N><A><I><R><E><V><L><E><L><D><S><I><R><S><H><H><W><C><I><Q><G><C><S><A><V><T><G><E><N><L><L><P><G><I><D><W><L><L><D><D><I><S><S><R><I><F><T><A><D> | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle . Also regulates mitochondrial integrity and function .<BOP> | P36404 |
P35452 | HXD12_HUMAN | Homeobox protein Hox-4H | Homo | <M><C><E><R><S><L><Y><R><A><G><Y><V><G><S><L><L><N><L><Q><S><P><D><S><F><Y><F><S><N><L><R><P><N><G><G><Q><L><A><A><L><P><P><I><S><Y><P><R><G><A><L><P><W><A><A><T><P><A><S><C><A><P><A><Q><P><A><G><A><T><A><F><G><G><F><S><Q><P><Y><L><A><G><S><G><P><L><G><L><Q><P><P><T><A><K><D><G><P><E><E><Q><A><K><F><Y><A><P><E><A><A><A><G><P><E><E><R><G><R><T><R><P><S><F><A><P><E><S><S><L><A><P><A><V><A><A><L><K><A><A><K><Y><D><Y><A><G><V><G><R><A><T><P><G><S><T><T><L><L><Q><G><A><P><C><A><P><G><F><K><D><D><T><K><G><P><L><N><L><N><M><T><V><Q><A><A><G><V><A><S><C><L><R><P><S><L><P><D><G><L><P><W><G><A><A><P><G><R><A><R><K><K><R><K><P><Y><T><K><Q><Q><I><A><E><L><E><N><E><F><L><V><N><E><F><I><N><R><Q><K><R><K><E><L><S><N><R><L><N><L><S><D><Q><Q><V><K><I><W><F><Q><N><R><R><M><K><K><K><R><V><V><L><R><E><Q><A><L><A><L><Y> | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP> | P35452 |
Q6XZB0 | LIPI_HUMAN | Membrane-associated phosphatidic acid-selective phospholipase A1-beta | Homo | <M><R><V><Y><I><F><L><C><L><M><C><W><V><R><S><D><N><K><R><P><C><L><E><F><S><Q><L><S><V><K><D><S><F><R><D><L><F><I><P><R><I><E><T><I><L><M><M><Y><T><R><N><N><L><N><C><A><E><P><L><F><E><Q><N><N><S><L><N><V><N><F><N><T><Q><K><K><T><V><W><L><I><H><G><Y><R><P><V><G><S><I><P><L><W><L><Q><N><F><V><R><I><L><L><N><E><E><D><M><N><V><I><V><V><D><W><S><R><G><A><T><T><F><I><Y><N><R><A><V><K><N><T><R><K><V><A><V><S><L><S><V><H><I><K><N><L><L><K><H><G><A><S><L><D><N><F><H><F><I><G><V><S><L><G><A><H><I><S><G><F><V><G><K><I><F><H><G><Q><L><G><R><I><T><G><L><D><P><A><G><P><R><F><S><R><K><P><P><Y><S><R><L><D><Y><T><D><A><K><F><V><D><V><I><H><S><D><S><N><G><L><G><I><Q><E><P><L><G><H><I><D><F><Y><P><N><G><G><N><K><Q><P><G><C><P><K><S><I><F><S><G><I><Q><F><I><K><C><N><H><Q><R><A><V><H><L><F><M><A><S><L><E><T><N><C><N><F><I><S><F><P><C><R><S><Y><K><D><Y><K><T><S><L><C><V><D><C><D><C><F><K><E><K><S><C><P><R><L><G><Y><Q><A><K><L><F><K><G><V><L><K><E><R><M><E><G><R><P><L><R><T><T><V><F><L><D><T><S><G><T><Y><P><F><C><T><Y><Y><F><V><L><S><I><I><V><P><D><K><T><M><M><D><G><S><F><S><F><K><L><L><N><Q><L><G><M><I><E><E><P><R><L><Y><E><K><N><K><P><F><Y><K><L><Q><E><V><K><I><L><A><Q><F><Y><N><D><F><V><N><I><S><S><I><G><L><T><Y><F><Q><S><S><N><L><Q><C><S><T><C><T><Y><K><I><Q><S><L><M><L><K><S><L><T><Y><P><E><R><P><P><L><C><R><Y><N><I><V><L><K><D><R><E><E><V><F><L><N><P><N><T><C><T><P><K><N><T> | Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).<BOP> | Q6XZB0 |
A0A0A6YYD4 | TVB13_HUMAN | T cell receptor beta variable 13 | Homo | <M><L><S><P><D><L><P><D><S><A><W><N><T><R><L><L><C><R><V><M><L><C><L><L><G><A><G><S><V><A><A><G><V><I><Q><S><P><R><H><L><I><K><E><K><R><E><T><A><T><L><K><C><Y><P><I><P><R><H><D><T><V><Y><W><Y><Q><Q><G><P><G><Q><D><P><Q><F><L><I><S><F><Y><E><K><M><Q><S><D><K><G><S><I><P><D><R><F><S><A><Q><Q><F><S><D><Y><H><S><E><L><N><M><S><S><L><E><L><G><D><S><A><L><Y><F><C><A><S><S><L> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0A6YYD4 |
Q15800 | MSMO1_HUMAN | Sterol-C4-methyl oxidase | Homo | <M><A><T><N><E><S><V><S><I><F><S><S><A><S><L><A><V><E><Y><V><D><S><L><L><P><E><N><P><L><Q><E><P><F><K><N><A><W><N><Y><M><L><N><N><Y><T><K><F><Q><I><A><T><W><G><S><L><I><V><H><E><A><L><Y><F><L><F><C><L><P><G><F><L><F><Q><F><I><P><Y><M><K><K><Y><K><I><Q><K><D><K><P><E><T><W><E><N><Q><W><K><C><F><K><V><L><L><F><N><H><F><C><I><Q><L><P><L><I><C><G><T><Y><Y><F><T><E><Y><F><N><I><P><Y><D><W><E><R><M><P><R><W><Y><F><L><L><A><R><C><F><G><C><A><V><I><E><D><T><W><H><Y><F><L><H><R><L><L><H><H><K><R><I><Y><K><Y><I><H><K><V><H><H><E><F><Q><A><P><F><G><M><E><A><E><Y><A><H><P><L><E><T><L><I><L><G><T><G><F><F><I><G><I><V><L><L><C><D><H><V><I><L><L><W><A><W><V><T><I><R><L><L><E><T><I><D><V><H><S><G><Y><D><I><P><L><N><P><L><N><L><I><P><F><Y><A><G><S><R><H><H><D><F><H><H><M><N><F><I><G><N><Y><A><S><T><F><T><W><W><D><R><I><F><G><T><D><S><Q><Y><N><A><Y><N><E><K><R><K><K><F><E><K><K><T><E> | Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol . Also involved in drug metabolism, as it can metabolize eldecalcitol (ED-71 or 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol), a second-generation vitamin D analog, into 1alpha,2beta,25-trihydroxy vitamin D3; this reaction occurs via enzymatic hydroxylation and spontaneous O-dehydroxypropylation .<BOP> | Q15800 |
P49758 | RGS6_HUMAN | S914 | Homo | <M><A><Q><G><S><G><D><Q><R><A><V><G><V><A><D><P><E><E><S><S><P><N><M><I><V><Y><C><K><I><E><D><I><I><T><K><M><Q><D><D><K><T><G><G><V><P><I><R><T><V><K><S><F><L><S><K><I><P><S><V><V><T><G><T><D><I><V><Q><W><L><M><K><N><L><S><I><E><D><P><V><E><A><I><H><L><G><S><L><I><A><A><Q><G><Y><I><F><P><I><S><D><H><V><L><T><M><K><D><D><G><T><F><Y><R><F><Q><A><P><Y><F><W><P><S><N><C><W><E><P><E><N><T><D><Y><A><I><Y><L><C><K><R><T><M><Q><N><K><A><R><L><E><L><A><D><Y><E><A><E><N><L><A><R><L><Q><R><A><F><A><R><K><W><E><F><I><F><M><Q><A><E><A><Q><V><K><I><D><R><K><K><D><K><T><E><R><K><I><L><D><S><Q><E><R><A><F><W><D><V><H><R><P><V><P><G><C><V><N><T><T><E><M><D><I><R><K><C><R><R><L><K><N><P><Q><K><V><K><K><S><V><Y><G><V><T><E><E><S><Q><A><Q><S><P><V><H><V><L><S><Q><P><I><R><K><T><T><K><E><D><I><R><K><Q><I><T><F><L><N><A><Q><I><D><R><H><C><L><K><M><S><K><V><A><E><S><L><I><A><Y><T><E><Q><Y><V><E><Y><D><P><L><I><T><P><A><E><P><S><N><P><W><I><S><D><D><V><A><L><W><D><I><E><M><S><K><E><P><S><Q><Q><R><V><K><R><W><G><F><S><F><D><E><I><L><K><D><Q><V><G><R><D><Q><F><L><R><F><L><E><S><E><F><S><S><E><N><L><R><F><W><L><A><V><Q><D><L><K><K><Q><P><L><Q><D><V><A><K><R><V><E><E><I><W><Q><E><F><L><A><P><G><A><P><S><A><I><N><L><D><S><H><S><Y><E><I><T><S><Q><N><V><K><D><G><G><R><Y><T><F><E><D><A><Q><E><H><I><Y><K><L><M><K><S><D><S><Y><A><R><F><L><R><S><N><A><Y><Q><D><L><L><L><A><K><K><K><G><K><S><L><A><G><K><R><L><T><G><L><M><Q><S><S> | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity .<BOP> | P49758 |
Q9UNS2 | CSN3_HUMAN | JAB1-containing signalosome subunit 3 | Homo | <M><A><S><A><L><E><Q><F><V><N><S><V><R><Q><L><S><A><Q><G><Q><M><T><Q><L><C><E><L><I><N><K><S><G><E><L><L><A><K><N><L><S><H><L><D><T><V><L><G><A><L><D><V><Q><E><H><S><L><G><V><L><A><V><L><F><V><K><F><S><M><P><S><V><P><D><F><E><T><L><F><S><Q><V><Q><L><F><I><S><T><C><N><G><E><H><I><R><Y><A><T><D><T><F><A><G><L><C><H><Q><L><T><N><A><L><V><E><R><K><Q><P><L><R><G><I><G><I><L><K><Q><A><I><D><K><M><Q><M><N><T><N><Q><L><T><S><I><H><A><D><L><C><Q><L><C><L><L><A><K><C><F><K><P><A><L><P><Y><L><D><V><D><M><M><D><I><C><K><E><N><G><A><Y><D><A><K><H><F><L><C><Y><Y><Y><Y><G><G><M><I><Y><T><G><L><K><N><F><E><R><A><L><Y><F><Y><E><Q><A><I><T><T><P><A><M><A><V><S><H><I><M><L><E><S><Y><K><K><Y><I><L><V><S><L><I><L><L><G><K><V><Q><Q><L><P><K><Y><T><S><Q><I><V><G><R><F><I><K><P><L><S><N><A><Y><H><E><L><A><Q><V><Y><S><T><N><N><P><S><E><L><R><N><L><V><N><K><H><S><E><T><F><T><R><D><N><N><M><G><L><V><K><Q><C><L><S><S><L><Y><K><K><N><I><Q><R><L><T><K><T><F><L><T><L><S><L><Q><D><M><A><S><R><V><Q><L><S><G><P><Q><E><A><E><K><Y><V><L><H><M><I><E><D><G><E><I><F><A><S><I><N><Q><K><D><G><M><V><S><F><H><D><N><P><E><K><Y><N><N><P><A><M><L><H><N><I><D><Q><E><M><L><K><C><I><E><L><D><E><R><L><K><A><M><D><Q><E><I><T><V><N><P><Q><F><V><Q><K><S><M><G><S><Q><E><D><D><S><G><N><K><P><S><S><Y><S> | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.<BOP> | Q9UNS2 |
Q92737 | RSLAA_HUMAN | Ras-related protein on chromosome 22 | Homo | <M><G><G><S><L><R><V><A><V><L><G><A><P><G><V><G><K><T><A><I><I><R><Q><F><L><F><G><D><Y><P><E><R><H><R><P><T><D><G><P><R><L><Y><R><P><A><V><L><L><D><G><A><V><Y><D><L><S><I><R><D><G><D><V><A><G><P><G><S><S><P><G><G><P><E><E><W><P><D><A><K><D><W><S><L><Q><D><T><D><A><F><V><L><V><Y><D><I><C><S><P><D><S><F><D><Y><V><K><A><L><R><Q><R><I><A><E><T><R><P><A><G><A><P><E><A><P><I><L><V><V><G><N><K><R><D><R><Q><R><L><R><F><G><P><R><R><A><L><A><A><L><V><R><R><G><W><R><C><G><Y><L><E><C><S><A><K><Y><N><W><H><V><L><R><L><F><R><E><L><L><R><C><A><L><V><R><A><R><P><A><H><P><A><L><R><L><Q><G><A><L><H><P><A><R><C><S><L><M> | Potent inhibitor of cellular proliferation.<BOP> | Q92737 |
Q8NH72 | OR4C6_HUMAN | Olfactory receptor OR11-138 | Homo | <M><E><N><Q><N><N><V><T><E><F><I><L><L><G><L><T><E><N><L><E><L><W><K><I><F><S><A><V><F><L><V><M><Y><V><A><T><V><L><E><N><L><L><I><V><V><T><I><I><T><S><Q><S><L><R><S><P><M><Y><F><F><L><T><F><L><S><L><L><D><V><M><F><S><S><V><V><A><P><K><V><I><V><D><T><L><S><K><S><T><T><I><S><L><K><G><C><L><T><Q><L><F><V><E><H><F><F><G><G><V><G><I><I><L><L><T><V><M><A><Y><D><R><Y><V><A><I><C><K><P><L><H><Y><T><I><I><M><S><P><R><V><C><C><L><M><V><G><G><A><W><V><G><G><F><M><H><A><M><I><Q><L><L><F><M><Y><Q><I><P><F><C><G><P><N><I><I><D><H><F><I><C><D><L><F><Q><L><L><T><L><A><C><T><D><T><H><I><L><G><L><L><V><T><L><N><S><G><M><M><C><V><A><I><F><L><I><L><I><A><S><Y><T><V><I><L><C><S><L><K><S><Y><S><S><K><G><R><H><K><A><L><S><T><C><S><S><H><L><T><V><V><V><L><F><F><V><P><C><I><F><L><Y><M><R><P><V><V><T><H><P><I><D><K><A><M><A><V><S><D><S><I><I><T><P><M><L><N><P><L><I><Y><T><L><R><N><A><E><V><K><S><A><M><K><K><L><W><M><K><W><E><A><L><A><G><K> | Odorant receptor.<BOP> | Q8NH72 |
Q969H0 | FBXW7_HUMAN | hCdc4 | Homo | <M><N><Q><E><L><L><S><V><G><S><K><R><R><R><T><G><G><S><L><R><G><N><P><S><S><S><Q><V><D><E><E><Q><M><N><R><V><V><E><E><E><Q><Q><Q><Q><L><R><Q><Q><E><E><E><H><T><A><R><N><G><E><V><V><G><V><E><P><R><P><G><G><Q><N><D><S><Q><Q><G><Q><L><E><E><N><N><N><R><F><I><S><V><D><E><D><S><S><G><N><Q><E><E><Q><E><E><D><E><E><H><A><G><E><Q><D><E><E><D><E><E><E><E><E><M><D><Q><E><S><D><D><F><D><Q><S><D><D><S><S><R><E><D><E><H><T><H><T><N><S><V><T><N><S><S><S><I><V><D><L><P><V><H><Q><L><S><S><P><F><Y><T><K><T><T><K><M><K><R><K><L><D><H><G><S><E><V><R><S><F><S><L><G><K><K><P><C><K><V><S><E><Y><T><S><T><T><G><L><V><P><C><S><A><T><P><T><T><F><G><D><L><R><A><A><N><G><Q><G><Q><Q><R><R><R><I><T><S><V><Q><P><P><T><G><L><Q><E><W><L><K><M><F><Q><S><W><S><G><P><E><K><L><L><A><L><D><E><L><I><D><S><C><E><P><T><Q><V><K><H><M><M><Q><V><I><E><P><Q><F><Q><R><D><F><I><S><L><L><P><K><E><L><A><L><Y><V><L><S><F><L><E><P><K><D><L><L><Q><A><A><Q><T><C><R><Y><W><R><I><L><A><E><D><N><L><L><W><R><E><K><C><K><E><E><G><I><D><E><P><L><H><I><K><R><R><K><V><I><K><P><G><F><I><H><S><P><W><K><S><A><Y><I><R><Q><H><R><I><D><T><N><W><R><R><G><E><L><K><S><P><K><V><L><K><G><H><D><D><H><V><I><T><C><L><Q><F><C><G><N><R><I><V><S><G><S><D><D><N><T><L><K><V><W><S><A><V><T><G><K><C><L><R><T><L><V><G><H><T><G><G><V><W><S><S><Q><M><R><D><N><I><I><I><S><G><S><T><D><R><T><L><K><V><W><N><A><E><T><G><E><C><I><H><T><L><Y><G><H><T><S><T><V><R><C><M><H><L><H><E><K><R><V><V><S><G><S><R><D><A><T><L><R><V><W><D><I><E><T><G><Q><C><L><H><V><L><M><G><H><V><A><A><V><R><C><V><Q><Y><D><G><R><R><V><V><S><G><A><Y><D><F><M><V><K><V><W><D><P><E><T><E><T><C><L><H><T><L><Q><G><H><T><N><R><V><Y><S><L><Q><F><D><G><I><H><V><V><S><G><S><L><D><T><S><I><R><V><W><D><V><E><T><G><N><C><I><H><T><L><T><G><H><Q><S><L><T><S><G><M><E><L><K><D><N><I><L><V><S><G><N><A><D><S><T><V><K><I><W><D><I><K><T><G><Q><C><L><Q><T><L><Q><G><P><N><K><H><Q><S><A><V><T><C><L><Q><F><N><K><N><F><V><I><T><S><S><D><D><G><T><V><K><L><W><D><L><K><T><G><E><F><I><R><N><L><V><T><L><E><S><G><G><S><G><G><V><V><W><R><I><R><A><S><N><T><K><L><V><C><A><V><G><S><R><N><G><T><E><E><T><K><L><L><V><L><D><F><D><V><D><M><K> | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination . Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NFE2L1, NOTCH2, MCL1, RICTOR, and probably PSEN1 . Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation . Involved in bone homeostasis and negative regulation of osteoclast differentiation . Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination . Also able to promote 'Lys-6 | Q969H0 |
O75949 | NALF2_HUMAN | Transmembrane protein FAM155B | Homo | <M><F><R><G><A><W><M><W><P><G><K><D><A><A><A><L><T><I><C><C><C><C><C><C><W><A><P><R><P><S><D><K><P><C><A><D><S><E><R><A><Q><R><W><R><L><S><L><A><S><L><L><F><F><T><V><L><L><A><D><H><L><W><L><C><A><G><A><R><P><R><A><R><E><L><S><S><A><M><R><P><P><W><G><A><G><R><E><R><Q><P><V><P><P><R><A><V><L><P><L><P><P><P><P><P><G><E><P><S><A><P><P><G><T><C><G><P><R><Y><S><N><L><T><K><A><A><P><A><A><G><S><R><P><V><C><G><G><V><P><E><P><T><G><L><D><A><A><C><T><K><L><Q><S><L><Q><R><L><F><E><P><T><T><P><A><P><P><L><R><P><P><D><S><L><S><R><A><P><A><E><F><P><S><A><K><K><N><L><L><K><G><H><F><R><N><F><T><L><S><F><C><D><T><Y><T><V><W><D><L><L><L><G><M><D><R><P><D><S><L><D><C><S><L><D><T><L><M><G><D><L><L><A><V><V><A><S><P><G><S><G><A><W><E><A><C><S><N><C><I><E><A><Y><Q><R><L><D><R><H><A><Q><E><K><Y><D><E><F><D><L><V><L><H><K><Y><L><Q><A><E><E><Y><S><I><R><S><C><T><K><G><C><K><A><V><Y><K><A><W><L><C><S><E><Y><F><S><V><T><Q><Q><E><C><Q><R><W><V><P><C><K><Q><Y><C><L><E><V><Q><T><R><C><P><F><I><L><P><D><N><E><E><M><V><Y><G><G><L><P><G><F><I><C><T><G><L><L><D><T><S><P><K><R><L><E><T><K><C><C><D><V><Q><W><V><S><C><E><A><K><K><K><K><F><K><E><S><E><A><P><K><T><H><Q><Q><Q><F><H><H><S><Y><F><H><H><Y><H><Q><Q><Y><H><H><Y><H><P><H><H><D><P><P><G><R><V><S><N><K><P><A><L><L><P><V><S><G><G><S><R><L><S><P><S><R><I><R><L><C><V><L><V><L><M><L><L><H><T><V><V><S><F><S><S><N><Q><G><G><G><G><L><G><L><E><T><L><P><A><L><E><E><G><L><T><R><E><E> | Probable component of the NALCN channel complex, a channel that regulates the resting membrane potential and controls neuronal excitability.<BOP> | O75949 |
P61221 | ABCE1_HUMAN | Ribonuclease 4 inhibitor | Homo | <M><A><D><K><L><T><R><I><A><I><V><N><H><D><K><C><K><P><K><K><C><R><Q><E><C><K><K><S><C><P><V><V><R><M><G><K><L><C><I><E><V><T><P><Q><S><K><I><A><W><I><S><E><T><L><C><I><G><C><G><I><C><I><K><K><C><P><F><G><A><L><S><I><V><N><L><P><S><N><L><E><K><E><T><T><H><R><Y><C><A><N><A><F><K><L><H><R><L><P><I><P><R><P><G><E><V><L><G><L><V><G><T><N><G><I><G><K><S><T><A><L><K><I><L><A><G><K><Q><K><P><N><L><G><K><Y><D><D><P><P><D><W><Q><E><I><L><T><Y><F><R><G><S><E><L><Q><N><Y><F><T><K><I><L><E><D><D><L><K><A><I><I><K><P><Q><Y><V><D><Q><I><P><K><A><A><K><G><T><V><G><S><I><L><D><R><K><D><E><T><K><T><Q><A><I><V><C><Q><Q><L><D><L><T><H><L><K><E><R><N><V><E><D><L><S><G><G><E><L><Q><R><F><A><C><A><V><V><C><I><Q><K><A><D><I><F><M><F><D><E><P><S><S><Y><L><D><V><K><Q><R><L><K><A><A><I><T><I><R><S><L><I><N><P><D><R><Y><I><I><V><V><E><H><D><L><S><V><L><D><Y><L><S><D><F><I><C><C><L><Y><G><V><P><S><A><Y><G><V><V><T><M><P><F><S><V><R><E><G><I><N><I><F><L><D><G><Y><V><P><T><E><N><L><R><F><R><D><A><S><L><V><F><K><V><A><E><T><A><N><E><E><E><V><K><K><M><C><M><Y><K><Y><P><G><M><K><K><K><M><G><E><F><E><L><A><I><V><A><G><E><F><T><D><S><E><I><M><V><M><L><G><E><N><G><T><G><K><T><T><F><I><R><M><L><A><G><R><L><K><P><D><E><G><G><E><V><P><V><L><N><V><S><Y><K><P><Q><K><I><S><P><K><S><T><G><S><V><R><Q><L><L><H><E><K><I><R><D><A><Y><T><H><P><Q><F><V><T><D><V><M><K><P><L><Q><I><E><N><I><I><D><Q><E><V><Q><T><L><S><G><G><E><L><Q><R><V><A><L><A><L><C><L><G><K><P><A><D><V><Y><L><I><D><E><P><S><A><Y><L><D><S><E><Q><R><L><M><A><A><R><V><V><K><R><F><I><L><H><A><K><K><T><A><F><V><V><E><H><D><F><I><M><A><T><Y><L><A><D><R><V><I><V><F><D><G><V><P><S><K><N><T><V><A><N><S><P><Q><T><L><L><A><G><M><N><K><F><L><S><Q><L><E><I><T><F><R><R><D><P><N><N><Y><R><P><R><I><N><K><L><N><S><I><K><D><V><E><Q><K><K><S><G><N><Y><F><F><L><D><D> | (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections.<BOP> | P61221 |
Q5VZV1 | MT21C_HUMAN | Methyltransferase-like protein 21C | Homo | <M><D><V><C><L><S><S><A><Q><Q><P><G><R><R><G><E><G><L><S><S><P><G><G><W><L><E><A><E><K><K><G><A><P><Q><K><D><S><T><G><G><V><L><E><E><S><N><K><I><E><P><S><L><H><S><L><Q><K><F><V><P><T><D><Y><A><S><Y><T><Q><E><H><Y><R><F><A><G><K><E><I><V><I><Q><E><S><I><E><S><Y><G><A><V><V><W><P><G><A><M><A><L><C><Q><Y><L><E><E><H><A><E><E><L><N><F><Q><D><A><K><I><L><E><I><G><A><G><P><G><L><V><S><I><V><A><S><I><L><G><A><Q><V><T><A><T><D><L><P><D><V><L><G><N><L><Q><Y><N><L><L><K><N><T><L><Q><C><T><A><H><L><P><E><V><K><E><L><V><W><G><E><D><L><D><K><N><F><P><K><S><A><F><Y><Y><D><Y><V><L><A><S><D><V><V><Y><H><H><Y><F><L><D><K><L><L><T><T><M><V><Y><L><S><Q><P><G><T><V><L><L><W><A><N><K><F><R><F><S><T><D><Y><E><F><L><D><K><F><K><Q><V><F><D><T><T><L><L><A><E><Y><P><E><S><S><V><K><L><F><K><G><I><L><K><W><D> | Protein-lysine methyltransferase.<BOP> | Q5VZV1 |
Q13112 | CAF1B_HUMAN | M-phase phosphoprotein 7 | Homo | <M><K><V><I><T><C><E><I><A><W><H><N><K><E><P><V><Y><S><L><D><F><Q><H><G><T><A><G><R><I><H><R><L><A><S><A><G><V><D><T><N><V><R><I><W><K><V><E><K><G><P><D><G><K><A><I><V><E><F><L><S><N><L><A><R><H><T><K><A><V><N><V><V><R><F><S><P><T><G><E><I><L><A><S><G><G><D><D><A><V><I><L><L><W><K><V><N><D><N><K><E><P><E><Q><I><A><F><Q><D><E><D><E><A><Q><L><N><K><E><N><W><T><V><V><K><T><L><R><G><H><L><E><D><V><Y><D><I><C><W><A><T><D><G><N><L><M><A><S><A><S><V><D><N><T><A><I><I><W><D><V><S><K><G><Q><K><I><S><I><F><N><E><H><K><S><Y><V><Q><G><V><T><W><D><P><L><G><Q><Y><V><A><T><L><S><C><D><R><V><L><R><V><Y><S><I><Q><K><K><R><V><A><F><N><V><S><K><M><L><S><G><I><G><A><E><G><E><A><R><S><Y><R><M><F><H><D><D><S><M><K><S><F><F><R><R><L><S><F><T><P><D><G><S><L><L><L><T><P><A><G><C><V><E><S><G><E><N><V><M><N><T><T><Y><V><F><S><R><K><N><L><K><R><P><I><A><H><L><P><C><P><G><K><A><T><L><A><V><R><C><C><P><V><Y><F><E><L><R><P><V><V><E><T><G><V><E><L><M><S><L><P><Y><R><L><V><F><A><V><A><S><E><D><S><V><L><L><Y><D><T><Q><Q><S><F><P><F><G><Y><V><S><N><I><H><Y><H><T><L><S><D><I><S><W><S><S><D><G><A><F><L><A><I><S><S><T><D><G><Y><C><S><F><V><T><F><E><K><D><E><L><G><I><P><L><K><E><K><P><V><L><N><M><R><T><P><D><T><A><K><K><T><K><S><Q><T><H><R><G><S><S><P><G><P><R><P><V><E><G><T><P><A><S><R><T><Q><D><P><S><S><P><G><T><T><P><P><Q><A><R><Q><A><P><A><P><T><V><I><R><D><P><P><S><I><T><P><A><V><K><S><P><L><P><G><P><S><E><E><K><T><L><Q><P><S><S><Q><N><T><K><A><H><P><S><R><R><V><T><L><N><T><L><Q><A><W><S><K><T><T><P><R><R><I><N><L><T><P><L><K><T><D><T><P><P><S><S><V><P><T><S><V><I><S><T><P><S><T><E><E><I><Q><S><E><T><P><G><D><A><Q><G><S><P><P><E><L><K><R><P><R><L><D><E><N><K><G><G><T><E><S><L><D><P> | Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.<BOP> | Q13112 |
Q9UK28 | TM59L_HUMAN | Brain-specific membrane-anchored protein | Homo | <M><A><A><V><A><L><M><P><P><P><L><L><L><L><L><L><L><A><S><P><P><A><A><S><A><P><S><A><R><D><P><F><A><P><Q><L><G><D><T><Q><N><C><Q><L><R><C><R><D><R><D><L><G><P><Q><P><S><Q><A><G><L><E><G><A><S><E><S><P><Y><D><R><A><V><L><I><S><A><C><E><R><G><C><R><L><F><S><I><C><R><F><V><A><R><S><S><K><P><N><A><T><Q><T><E><C><E><A><A><C><V><E><A><Y><V><K><E><A><E><Q><Q><A><C><S><H><G><C><W><S><Q><P><A><E><P><E><P><E><Q><K><R><K><V><L><E><A><P><S><G><A><L><S><L><L><D><L><F><S><T><L><C><N><D><L><V><N><S><A><Q><G><F><V><S><S><T><W><T><Y><Y><L><Q><T><D><N><G><K><V><V><V><F><Q><T><Q><P><I><V><E><S><L><G><F><Q><G><G><R><L><Q><R><V><E><V><T><W><R><G><S><H><P><E><A><L><E><V><H><V><D><P><V><G><P><L><D><K><V><R><K><A><K><I><R><V><K><T><S><S><K><A><K><V><E><S><E><E><P><Q><D><N><D><F><L><S><C><M><S><R><R><S><G><L><P><R><W><I><L><A><C><C><L><F><L><S><V><L><V><M><L><W><L><S><C><S><T><L><V><T><A><P><G><Q><H><L><K><F><Q><P><L><T><L><E><Q><H><K><G><F><M><M><E><P><D><W><P><L><Y><P><P><P><S><H><A><C><E><D><S><L><P><P><Y><K><L><K><L><D><L><T><K><L> | Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.<BOP> | Q9UK28 |
Q8NGJ9 | O51T1_HUMAN | Olfactory receptor OR11-26 | Homo | <M><A><I><F><N><N><T><T><S><S><S><S><N><F><L><L><T><A><F><P><G><L><E><C><A><H><V><W><I><S><I><P><V><C><C><L><Y><T><I><A><L><L><G><N><S><M><I><F><L><V><I><I><T><K><R><R><L><H><K><P><M><Y><Y><F><L><S><M><L><A><A><V><D><L><C><L><T><I><T><T><L><P><T><V><L><G><V><L><W><F><H><A><R><E><I><S><F><K><A><C><F><I><Q><M><F><F><V><H><A><F><S><L><L><E><S><S><V><L><V><A><M><A><F><D><R><F><V><A><I><C><N><P><L><N><Y><A><T><I><L><T><D><R><M><V><L><V><I><G><L><V><I><C><I><R><P><A><V><F><L><L><P><L><L><V><A><I><N><T><V><S><F><H><G><G><H><E><L><S><H><P><F><C><Y><H><P><E><V><I><K><Y><T><Y><S><K><P><W><I><S><S><F><W><G><L><F><L><Q><L><Y><L><N><G><T><D><V><L><F><I><L><F><S><Y><V><L><I><L><R><T><V><L><G><I><V><A><R><K><K><Q><Q><K><A><L><S><T><C><V><C><H><I><C><A><V><T><I><F><Y><V><P><L><I><S><L><S><L><A><H><R><L><F><H><S><T><P><R><V><L><C><S><T><L><A><N><I><Y><L><L><L><P><P><V><L><N><P><I><I><Y><S><L><K><T><K><T><I><R><Q><A><M><F><Q><L><L><Q><S><K><G><S><W><G><F><N><V><R><G><L><R><G><R><W><D> | Odorant receptor.<BOP> | Q8NGJ9 |
P14621 | ACYP2_HUMAN | Acylphosphate phosphohydrolase 2 | Homo | <M><S><T><A><Q><S><L><K><S><V><D><Y><E><V><F><G><R><V><Q><G><V><C><F><R><M><Y><T><E><D><E><A><R><K><I><G><V><V><G><W><V><K><N><T><S><K><G><T><V><T><G><Q><V><Q><G><P><E><D><K><V><N><S><M><K><S><W><L><S><K><V><G><S><P><S><S><R><I><D><R><T><N><F><S><N><E><K><T><I><S><K><L><E><Y><S><N><F><S><I><R><Y> | Its physiological role is not yet clear.<BOP> | P14621 |
Q9P2W3 | GBG13_HUMAN | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 | Homo | <M><E><E><W><D><V><P><Q><M><K><K><E><V><E><S><L><K><Y><Q><L><A><F><Q><R><E><M><A><S><K><T><I><P><E><L><L><K><W><I><E><D><G><I><P><K><D><P><F><L><N><P><D><L><M><K><N><N><P><W><V><E><K><G><K><C><T><I><L> | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<BOP> | Q9P2W3 |
Q96K21 | ANCHR_HUMAN | Zinc finger FYVE domain-containing protein 19 | Homo | <M><N><Y><D><S><Q><Q><P><P><L><P><P><L><P><Y><A><G><C><R><R><A><S><G><F><P><A><L><G><R><G><G><T><V><P><V><G><V><W><G><G><A><G><Q><G><R><E><G><R><S><W><G><E><G><P><R><G><P><G><L><G><R><R><D><L><S><S><A><D><P><A><V><L><G><A><T><M><E><S><R><C><Y><G><C><A><V><K><F><T><L><F><K><K><E><Y><G><C><K><N><C><G><R><A><F><C><S><G><C><L><S><F><S><A><A><V><P><R><T><G><N><T><Q><Q><K><V><C><K><Q><C><H><E><V><L><T><R><G><S><S><A><N><A><S><K><W><S><P><P><Q><N><Y><K><K><R><V><A><A><L><E><A><K><Q><K><P><S><T><S><Q><S><Q><G><L><T><R><Q><D><Q><M><I><A><E><R><L><A><R><L><R><Q><E><N><K><P><K><L><V><P><S><Q><A><E><I><E><A><R><L><A><A><L><K><D><E><R><Q><G><S><I><P><S><T><Q><E><M><E><A><R><L><A><A><L><Q><G><R><V><L><P><S><Q><T><P><Q><P><A><H><H><T><P><D><T><R><T><Q><A><Q><Q><T><Q><D><L><L><T><Q><L><A><A><E><V><A><I><D><E><S><W><K><G><G><G><P><A><A><S><L><Q><N><D><L><N><Q><G><G><P><G><S><T><N><S><K><R><Q><A><N><W><S><L><E><E><E><K><S><R><L><L><A><E><A><A><L><E><L><R><E><E><N><T><R><Q><E><R><I><L><A><L><A><K><R><L><A><M><L><R><G><Q><D><P><E><R><V><T><L><Q><D><Y><R><L><P><D><S><D><D><D><E><D><E><E><T><A><I><Q><R><V><L><Q><Q><L><T><E><E><A><S><L><D><E><A><S><G><F><N><I><P><A><E><Q><A><S><R><P><W><T><Q><P><R><G><A><E><P><E><A><Q><D><V><D><P><R><P><E><A><E><E><E><E><L><P><W><C><C><I><C><N><E><D><A><T><L><R><C><A><G><C><D><G><D><L><F><C><A><R><C><F><R><E><G><H><D><A><F><E><L><K><E><H><Q><T><S><A><Y><S><P><P><R><A><G><Q><E><H> | Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.<BOP> | Q96K21 |
Q96RQ1 | ERGI2_HUMAN | Endoplasmic reticulum-Golgi intermediate compartment protein 2 | Homo | <M><R><R><L><N><R><K><K><T><L><S><L><V><K><E><L><D><A><F><P><K><V><P><E><S><Y><V><E><T><S><A><S><G><G><T><V><S><L><I><A><F><T><T><M><A><L><L><T><I><M><E><F><S><V><Y><Q><D><T><W><M><K><Y><E><Y><E><V><D><K><D><F><S><S><K><L><R><I><N><I><D><I><T><V><A><M><K><C><Q><Y><V><G><A><D><V><L><D><L><A><E><T><M><V><A><S><A><D><G><L><V><Y><E><P><T><V><F><D><L><S><P><Q><Q><K><E><W><Q><R><M><L><Q><L><I><Q><S><R><L><Q><E><E><H><S><L><Q><D><V><I><F><K><S><A><F><K><S><T><S><T><A><L><P><P><R><E><D><D><S><S><Q><S><P><N><A><C><R><I><H><G><H><L><Y><V><N><K><V><A><G><N><F><H><I><T><V><G><K><A><I><P><H><P><R><G><H><A><H><L><A><A><L><V><N><H><E><S><Y><N><F><S><H><R><I><D><H><L><S><F><G><E><L><V><P><A><I><I><N><P><L><D><G><T><E><K><I><A><I><D><H><N><Q><M><F><Q><Y><F><I><T><V><V><P><T><K><L><H><T><Y><K><I><S><A><D><T><H><Q><F><S><V><T><E><R><E><R><I><I><N><H><A><A><G><S><H><G><V><S><G><I><F><M><K><Y><D><L><S><S><L><M><V><T><V><T><E><E><H><M><P><F><W><Q><F><F><V><R><L><C><G><I><V><G><G><I><F><S><T><T><G><M><L><H><G><I><G><K><F><I><V><E><I><I><C><C><R><F><R><L><G><S><Y><K><P><V><N><S><V><P><F><E><D><G><H><T><D><N><H><L><P><L><L><E><N><N><T><H> | Possible role in transport between endoplasmic reticulum and Golgi.<BOP> | Q96RQ1 |
Q5VUJ9 | DRC8_HUMAN | EF-hand calcium-binding domain-containing protein 2 | Homo | <M><L><G><P><G><Q><V><R><L><R><P><R><V><W><R><D><K><A><G><G><R><V><A><D><G><A><S><G><L><P><P><A><R><G><S><W><R><E><T><G><T><G><R><A><L><G><A><S><S><P><P><R><P><A><Q><G><S><S><S><P><G><I><Q><S><G><P><S><S><R><P><G><S><P><R><G><A><E><Q><A><G><T><P><R><P><R><L><S><L><G><I><S><Q><A><T><G><S><A><A><R><W><R><T><R><R><T><G><K><G><L><G><Y><N><S><D><E><I><R><P><R><T><L><L><I><E><H><L><M><E><G><G><R><R><D><H><H><T><M><T><V><L><W><G><T><Q><E><I><I><V><A><E><F><H><K><K><I><K><E><A><F><E><V><F><D><H><E><S><N><N><T><V><D><V><R><E><I><G><T><I><I><R><S><L><G><C><C><P><T><E><G><E><L><H><D><L><I><A><E><V><E><E><E><E><P><T><G><Y><I><R><F><E><K><F><L><P><V><M><T><E><I><L><L><E><R><K><Y><R><P><I><P><E><D><V><L><L><R><A><F><E><V><L><D><S><A><K><R><G><F><L><T><K><D><E><L><I><K><Y><M><T><E><E><D><G><V><S><L><R><R><P><G> | Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.<BOP> | Q5VUJ9 |
Q9HBV1 | POPD3_HUMAN | Popeye domain-containing protein 3 | Homo | <M><E><R><N><S><S><L><W><K><N><L><I><D><E><H><P><V><C><T><T><W><K><Q><E><A><E><G><A><I><Y><H><L><A><S><I><L><F><V><V><G><F><M><G><G><S><G><F><F><G><L><L><Y><V><F><S><L><L><G><L><G><F><L><C><S><A><V><W><A><W><V><D><V><C><A><A><D><I><F><S><W><N><F><V><L><F><V><I><C><F><M><Q><F><V><H><I><A><Y><Q><V><R><S><I><T><F><A><R><E><F><Q><V><L><Y><S><S><L><F><Q><P><L><G><I><S><L><P><V><F><R><T><I><A><L><S><S><E><V><V><T><L><E><K><E><H><C><Y><A><M><Q><G><K><T><S><I><D><K><L><S><L><L><V><S><G><R><I><R><V><T><V><D><G><E><F><L><H><Y><I><F><P><L><Q><F><L><D><S><P><E><W><D><S><L><R><P><T><E><E><G><I><F><Q><V><T><L><T><A><E><T><D><C><R><Y><V><S><W><R><R><K><K><L><Y><L><L><F><A><Q><H><R><Y><I><S><R><L><F><S><V><L><I><G><S><D><I><A><D><K><L><Y><A><L><N><D><R><V><Y><I><G><K><R><Y><H><Y><D><I><R><L><P><N><F><Y><Q><M><S><T><P><E><I><R><R><S><P><L><T><Q><H><F><Q><N><S><R><R><Y><C><D><K> | May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding. May play a role in the regulation of KCNK2/TREK-1-mediated current amplitude .<BOP> | Q9HBV1 |
P01215 | GLHA_HUMAN | Thyrotropin alpha chain | Homo | <M><D><Y><Y><R><K><Y><A><A><I><F><L><V><T><L><S><V><F><L><H><V><L><H><S><A><P><D><V><Q><D><C><P><E><C><T><L><Q><E><N><P><F><F><S><Q><P><G><A><P><I><L><Q><C><M><G><C><C><F><S><R><A><Y><P><T><P><L><R><S><K><K><T><M><L><V><Q><K><N><V><T><S><E><S><T><C><C><V><A><K><S><Y><N><R><V><T><V><M><G><G><F><K><V><E><N><H><T><A><C><H><C><S><T><C><Y><Y><H><K><S> | Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.<BOP> | P01215 |
Q5JX71 | F209A_HUMAN | Protein FAM209A | Homo | <M><W><T><L><K><S><S><L><V><L><L><L><C><L><T><C><S><Y><A><F><M><F><S><S><L><R><Q><K><T><S><E><P><Q><G><K><V><Q><Y><G><E><H><F><R><I><R><Q><N><L><P><E><H><T><Q><G><W><L><G><S><K><W><L><W><L><L><F><V><V><V><P><F><V><I><L><Q><C><Q><R><D><S><E><K><N><K><E><Q><S><P><P><G><L><R><G><G><Q><L><H><S><P><L><K><K><K><R><N><A><S><P><N><K><D><C><A><F><N><T><L><M><E><L><E><V><E><L><M><K><F><V><S><K><V><R><N><L><K><R><A><M><A><T><G><S><G><S><N><L><R><L><R><K><S><E><M><P><A><D><P><Y><H><V><T><I><C><E><I><W><G><E><E><S><S><S> | May play a role in sperm acrosome biogenesis.<BOP> | Q5JX71 |
Q08752 | PPID_HUMAN | Rotamase D | Homo | <M><S><H><P><S><P><Q><A><K><P><S><N><P><S><N><P><R><V><F><F><D><V><D><I><G><G><E><R><V><G><R><I><V><L><E><L><F><A><D><I><V><P><K><T><A><E><N><F><R><A><L><C><T><G><E><K><G><I><G><H><T><T><G><K><P><L><H><F><K><G><C><P><F><H><R><I><I><K><K><F><M><I><Q><G><G><D><F><S><N><Q><N><G><T><G><G><E><S><I><Y><G><E><K><F><E><D><E><N><F><H><Y><K><H><D><R><E><G><L><L><S><M><A><N><A><G><R><N><T><N><G><S><Q><F><F><I><T><T><V><P><T><P><H><L><D><G><K><H><V><V><F><G><Q><V><I><K><G><I><G><V><A><R><I><L><E><N><V><E><V><K><G><E><K><P><A><K><L><C><V><I><A><E><C><G><E><L><K><E><G><D><D><G><G><I><F><P><K><D><G><S><G><D><S><H><P><D><F><P><E><D><A><D><I><D><L><K><D><V><D><K><I><L><L><I><T><E><D><L><K><N><I><G><N><T><F><F><K><S><Q><N><W><E><M><A><I><K><K><Y><A><E><V><L><R><Y><V><D><S><S><K><A><V><I><E><T><A><D><R><A><K><L><Q><P><I><A><L><S><C><V><L><N><I><G><A><C><K><L><K><M><S><N><W><Q><G><A><I><D><S><C><L><E><A><L><E><L><D><P><S><N><T><K><A><L><Y><R><R><A><Q><G><W><Q><G><L><K><E><Y><D><Q><A><L><A><D><L><K><K><A><Q><G><I><A><P><E><D><K><A><I><Q><A><E><L><L><K><V><K><Q><K><I><K><A><Q><K><D><K><E><K><A><V><Y><A><K><M><F><A> | (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release.<BOP> | Q08752 |
O14645 | IDLC_HUMAN | hp28 | Homo | <M><I><P><P><A><D><S><L><L><K><Y><D><T><P><V><L><V><S><R><N><T><E><K><R><S><P><K><A><R><L><L><K><V><S><P><Q><Q><P><G><P><S><G><S><A><P><Q><P><P><K><T><K><L><P><S><T><P><C><V><P><D><P><T><K><Q><A><E><E><I><L><N><A><I><L><P><P><R><E><W><V><E><D><T><Q><L><W><I><Q><Q><V><S><S><T><P><S><T><R><M><D><V><V><H><L><Q><E><Q><L><D><L><K><L><Q><Q><R><Q><A><R><E><T><G><I><C><P><V><R><R><E><L><Y><S><Q><C><F><D><E><L><I><R><E><V><T><I><N><C><A><E><R><G><L><L><L><L><R><V><R><D><E><I><R><M><T><I><A><A><Y><Q><T><L><Y><E><S><S><V><A><F><G><M><R><K><A><L><Q><A><E><Q><G><K><S><D><M><E><R><K><I><A><E><L><E><T><E><K><R><D><L><E><R><Q><V><N><E><Q><K><A><K><C><E><A><T><E><K><R><E><S><E><R><R><Q><V><E><E><K><K><H><N><E><E><I><Q><F><L><K><R><T><N><Q><Q><L><K><A><Q><L><E><G><I><I><A><P><K><K> | May play a dynamic role in flagellar motility.<BOP> | O14645 |
P0DJD8 | PEPA3_HUMAN | Pepsinogen-3 | Homo | <M><K><W><L><L><L><L><G><L><V><A><L><S><E><C><I><M><Y><K><V><P><L><I><R><K><K><S><L><R><R><T><L><S><E><R><G><L><L><K><D><F><L><K><K><H><N><L><N><P><A><R><K><Y><F><P><Q><W><K><A><P><T><L><V><D><E><Q><P><L><E><N><Y><L><D><M><E><Y><F><G><T><I><G><I><G><T><P><A><Q><D><F><T><V><V><F><D><T><G><S><S><N><L><W><V><P><S><V><Y><C><S><S><L><A><C><T><N><H><N><R><F><N><P><E><D><S><S><T><Y><Q><S><T><S><E><T><V><S><I><T><Y><G><T><G><S><M><T><G><I><L><G><Y><D><T><V><Q><V><G><G><I><S><D><T><N><Q><I><F><G><L><S><E><T><E><P><G><S><F><L><Y><Y><A><P><F><D><G><I><L><G><L><A><Y><P><S><I><S><S><S><G><A><T><P><V><F><D><N><I><W><N><Q><G><L><V><S><Q><D><L><F><S><V><Y><L><S><A><D><D><Q><S><G><S><V><V><I><F><G><G><I><D><S><S><Y><Y><T><G><S><L><N><W><V><P><V><T><V><E><G><Y><W><Q><I><T><V><D><S><I><T><M><N><G><E><A><I><A><C><A><E><G><C><Q><A><I><V><D><T><G><T><S><L><L><T><G><P><T><S><P><I><A><N><I><Q><S><D><I><G><A><S><E><N><S><D><G><D><M><V><V><S><C><S><A><I><S><S><L><P><D><I><V><F><T><I><N><G><V><Q><Y><P><V><P><P><S><A><Y><I><L><Q><S><E><G><S><C><I><S><G><F><Q><G><M><N><L><P><T><E><S><G><E><L><W><I><L><G><D><V><F><I><R><Q><Y><F><T><V><F><D><R><A><N><N><Q><V><G><L><A><P><V><A> | Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.<BOP> | P0DJD8 |
P53370 | NUDT6_HUMAN | Protein GFG | Homo | <M><R><Q><P><L><S><W><G><R><W><R><A><M><L><A><R><T><Y><G><P><G><P><S><A><G><Y><R><W><A><S><G><A><Q><G><Y><V><R><N><P><P><V><G><A><C><D><L><Q><G><E><L><D><R><F><G><G><I><S><V><R><L><A><R><L><D><A><L><D><R><L><D><A><A><A><F><Q><K><G><L><Q><A><A><V><Q><Q><W><R><S><E><G><R><T><A><V><W><L><H><I><P><I><L><Q><S><R><F><I><A><P><A><A><S><L><G><F><C><F><H><H><A><E><S><D><S><S><T><L><T><L><W><L><R><E><G><P><S><R><L><P><G><Y><A><S><H><Q><V><G><V><A><G><A><V><F><D><E><S><T><R><K><I><L><V><V><Q><D><R><N><K><L><K><N><M><W><K><F><P><G><G><L><S><E><P><E><E><D><I><G><D><T><A><V><R><E><V><F><E><E><T><G><I><K><S><E><F><R><S><V><L><S><I><R><Q><Q><H><T><N><P><G><A><F><G><K><S><D><M><Y><I><I><C><R><L><K><P><Y><S><F><T><I><N><F><C><Q><E><E><C><L><R><C><E><W><M><D><L><N><D><L><A><K><T><E><N><T><T><P><I><T><S><R><V><A><R><L><L><L><Y><G><Y><R><E><G><F><D><K><I><D><L><T><V><E><E><L><P><A><V><Y><T><G><L><F><Y><K><L><Y><H><K><E><L><P><E><N><Y><K><T><M><K><G><I><D> | May contribute to the regulation of cell proliferation.<BOP> | P53370 |
Q8NGF4 | O5AP2_HUMAN | Olfactory receptor 5AP2 | Homo | <M><R><L><M><K><E><V><R><G><R><N><Q><T><E><V><T><E><F><L><L><L><G><L><S><D><N><P><D><L><Q><G><V><L><F><A><L><F><L><L><I><Y><M><A><N><M><V><G><N><L><G><M><I><V><L><I><K><I><D><L><C><L><H><T><P><M><Y><F><F><L><S><S><L><S><F><V><D><A><S><Y><S><S><S><V><T><P><K><M><L><V><N><L><M><A><E><N><K><A><I><S><F><H><G><C><A><A><Q><F><Y><F><F><G><S><F><L><G><T><E><C><F><L><L><A><M><M><A><Y><D><R><Y><A><A><I><W><N><P><L><L><Y><P><V><L><V><S><G><R><I><C><F><L><L><I><A><T><S><F><L><A><G><C><G><N><A><A><I><H><T><G><M><T><F><R><L><S><F><C><G><S><N><R><I><N><H><F><Y><C><D><T><P><P><L><L><K><L><S><C><S><D><T><H><F><N><G><I><V><I><M><A><F><S><S><F><I><V><I><S><C><V><M><I><V><L><I><S><Y><L><C><I><F><I><A><V><L><K><M><P><S><L><E><G><R><H><K><A><F><S><T><C><A><S><Y><L><M><A><V><T><I><F><F><G><T><I><L><F><M><Y><L><R><P><T><S><S><Y><S><M><E><Q><D><K><V><V><S><V><F><Y><T><V><I><I><P><V><L><N><P><L><I><Y><S><L><K><N><K><D><V><K><K><A><L><K><K><I><L><W><K><H><I><L> | Odorant receptor.<BOP> | Q8NGF4 |
P63000 | RAC1_HUMAN | p21-Rac1 | Homo | <M><Q><A><I><K><C><V><V><V><G><D><G><A><V><G><K><T><C><L><L><I><S><Y><T><T><N><A><F><P><G><E><Y><I><P><T><V><F><D><N><Y><S><A><N><V><M><V><D><G><K><P><V><N><L><G><L><W><D><T><A><G><Q><E><D><Y><D><R><L><R><P><L><S><Y><P><Q><T><D><V><F><L><I><C><F><S><L><V><S><P><A><S><F><E><N><V><R><A><K><W><Y><P><E><V><R><H><H><C><P><N><T><P><I><I><L><V><G><T><K><L><D><L><R><D><D><K><D><T><I><E><K><L><K><E><K><K><L><T><P><I><T><Y><P><Q><G><L><A><M><A><K><E><I><G><A><V><K><Y><L><E><C><S><A><L><T><Q><R><G><L><K><T><V><F><D><E><A><I><R><A><V><L><C><P><P><P><V><K><K><R><K><R><K><C><L><L><L> | Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins . It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction .<BOP> | P63000 |
Q8NHZ8 | CDC26_HUMAN | Cell division cycle protein 26 homolog | Homo | <M><L><R><R><K><P><T><R><L><E><L><K><L><D><D><I><E><E><F><E><N><I><R><K><D><L><E><T><R><K><K><Q><K><E><D><V><E><V><V><G><G><S><D><G><E><G><A><I><G><L><S><S><D><P><K><S><R><E><Q><M><I><N><D><R><I><G><Y><K><P><Q><P><K><P><N><N><R><S><S><Q><F><G><S><L><E><F> | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.<BOP> | Q8NHZ8 |
Q9H6B4 | CLMP_HUMAN | Coxsackie- and adenovirus receptor-like membrane protein | Homo | <M><S><L><L><L><L><L><L><L><V><S><Y><Y><V><G><T><L><G><T><H><T><E><I><K><R><V><A><E><E><K><V><T><L><P><C><H><H><Q><L><G><L><P><E><K><D><T><L><D><I><E><W><L><L><T><D><N><E><G><N><Q><K><V><V><I><T><Y><S><S><R><H><V><Y><N><N><L><T><E><E><Q><K><G><R><V><A><F><A><S><N><F><L><A><G><D><A><S><L><Q><I><E><P><L><K><P><S><D><E><G><R><Y><T><C><K><V><K><N><S><G><R><Y><V><W><S><H><V><I><L><K><V><L><V><R><P><S><K><P><K><C><E><L><E><G><E><L><T><E><G><S><D><L><T><L><Q><C><E><S><S><S><G><T><E><P><I><V><Y><Y><W><Q><R><I><R><E><K><E><G><E><D><E><R><L><P><P><K><S><R><I><D><Y><N><H><P><G><R><V><L><L><Q><N><L><T><M><S><Y><S><G><L><Y><Q><C><T><A><G><N><E><A><G><K><E><S><C><V><V><R><V><T><V><Q><Y><V><Q><S><I><G><M><V><A><G><A><V><T><G><I><V><A><G><A><L><L><I><F><L><L><V><W><L><L><I><R><R><K><D><K><E><R><Y><E><E><E><E><R><P><N><E><I><R><E><D><A><E><A><P><K><A><R><L><V><K><P><S><S><S><S><S><G><S><R><S><S><R><S><G><S><S><S><T><R><S><T><A><N><S><A><S><R><S><Q><R><T><L><S><T><D><A><A><P><Q><P><G><L><A><T><Q><A><Y><S><L><V><G><P><E><V><R><G><S><E><P><K><K><V><H><H><A><N><L><T><K><A><E><T><T><P><S><M><I><P><S><Q><S><R><A><F><Q><T><V> | May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.<BOP> | Q9H6B4 |
Q6PCB6 | AB17C_HUMAN | Alpha/beta hydrolase domain-containing protein 17C | Homo | <M><P><E><P><G><P><R><M><N><G><F><S><L><G><E><L><C><W><L><F><C><C><P><P><C><P><S><R><I><A><A><K><L><A><F><L><P><P><E><P><T><Y><T><V><L><A><P><E><Q><R><G><A><G><A><S><A><P><A><P><A><Q><A><T><A><A><A><A><A><A><Q><P><A><P><Q><Q><P><E><E><G><A><G><A><G><P><G><A><C><S><L><H><L><S><E><R><A><D><W><Q><Y><S><Q><R><E><L><D><A><V><E><V><F><F><S><R><T><A><R><D><N><R><L><G><C><M><F><V><R><C><A><P><S><S><R><Y><T><L><L><F><S><H><G><N><A><V><D><L><G><Q><M><C><S><F><Y><I><G><L><G><S><R><I><N><C><N><I><F><S><Y><D><Y><S><G><Y><G><V><S><S><G><K><P><S><E><K><N><L><Y><A><D><I><D><A><A><W><Q><A><L><R><T><R><Y><G><V><S><P><E><N><I><I><L><Y><G><Q><S><I><G><T><V><P><T><V><D><L><A><S><R><Y><E><C><A><A><V><I><L><H><S><P><L><M><S><G><L><R><V><A><F><P><D><T><R><K><T><Y><C><F><D><A><F><P><S><I><D><K><I><S><K><V><T><S><P><V><L><V><I><H><G><T><E><D><E><V><I><D><F><S><H><G><L><A><M><Y><E><R><C><P><R><A><V><E><P><L><W><V><E><G><A><G><H><N><D><I><E><L><Y><A><Q><Y><L><E><R><L><K><Q><F><I><S><H><E><L><P><N><S> | Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95.<BOP> | Q6PCB6 |
Q9NX57 | RAB20_HUMAN | Ras-related protein Rab-20 | Homo | <M><R><K><P><D><S><K><I><V><L><L><G><D><M><N><V><G><K><T><S><L><L><Q><R><Y><M><E><R><R><F><P><D><T><V><S><T><V><G><G><A><F><Y><L><K><Q><W><R><S><Y><N><I><S><I><W><D><T><A><G><R><E><Q><F><H><G><L><G><S><M><Y><C><R><G><A><A><A><I><I><L><T><Y><D><V><N><H><R><Q><S><L><V><E><L><E><D><R><F><L><G><L><T><D><T><A><S><K><D><C><L><F><A><I><V><G><N><K><V><D><L><T><E><E><G><A><L><A><G><Q><E><K><E><E><C><S><P><N><M><D><A><G><D><R><V><S><P><R><A><P><K><Q><V><Q><L><E><D><A><V><A><L><Y><K><K><I><L><K><Y><K><M><L><D><E><Q><D><V><P><A><A><E><Q><M><C><F><E><T><S><A><K><T><G><Y><N><V><D><L><L><F><E><T><L><F><D><L><V><V><P><M><I><L><Q><Q><R><A><E><R><P><S><H><T><V><D><I><S><S><H><K><P><P><K><R><T><R><S><G><C><C><A> | Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.<BOP> | Q9NX57 |
Q3ZCQ3 | F174B_HUMAN | Membrane protein FAM174B | Homo | <M><R><A><V><P><L><P><A><P><L><L><P><L><L><L><L><A><L><L><A><A><P><A><A><R><A><S><R><A><E><S><V><S><A><P><W><P><E><P><E><R><E><S><R><P><P><P><G><P><G><P><G><N><T><T><R><F><G><S><G><A><A><G><G><S><G><S><S><S><S><N><S><S><G><D><A><L><V><T><R><I><S><I><L><L><R><D><L><P><T><L><K><A><A><V><I><V><A><F><A><F><T><T><L><L><I><A><C><L><L><L><R><V><F><R><S><G><K><R><L><K><K><T><R><K><Y><D><I><I><T><T><P><A><E><R><V><E><M><A><P><L><N><E><E><D><D><E><D><E><D><S><T><V><F><D><I><K><Y><R> | Essential for Golgi structural integrity.<BOP> | Q3ZCQ3 |
Q12834 | CDC20_HUMAN | p55CDC | Homo | <M><A><Q><F><A><F><E><S><D><L><H><S><L><L><Q><L><D><A><P><I><P><N><A><P><P><A><R><W><Q><R><K><A><K><E><A><A><G><P><A><P><S><P><M><R><A><A><N><R><S><H><S><A><G><R><T><P><G><R><T><P><G><K><S><S><S><K><V><Q><T><T><P><S><K><P><G><G><D><R><Y><I><P><H><R><S><A><A><Q><M><E><V><A><S><F><L><L><S><K><E><N><Q><P><E><N><S><Q><T><P><T><K><K><E><H><Q><K><A><W><A><L><N><L><N><G><F><D><V><E><E><A><K><I><L><R><L><S><G><K><P><Q><N><A><P><E><G><Y><Q><N><R><L><K><V><L><Y><S><Q><K><A><T><P><G><S><S><R><K><T><C><R><Y><I><P><S><L><P><D><R><I><L><D><A><P><E><I><R><N><D><Y><Y><L><N><L><V><D><W><S><S><G><N><V><L><A><V><A><L><D><N><S><V><Y><L><W><S><A><S><S><G><D><I><L><Q><L><L><Q><M><E><Q><P><G><E><Y><I><S><S><V><A><W><I><K><E><G><N><Y><L><A><V><G><T><S><S><A><E><V><Q><L><W><D><V><Q><Q><Q><K><R><L><R><N><M><T><S><H><S><A><R><V><G><S><L><S><W><N><S><Y><I><L><S><S><G><S><R><S><G><H><I><H><H><H><D><V><R><V><A><E><H><H><V><A><T><L><S><G><H><S><Q><E><V><C><G><L><R><W><A><P><D><G><R><H><L><A><S><G><G><N><D><N><L><V><N><V><W><P><S><A><P><G><E><G><G><W><V><P><L><Q><T><F><T><Q><H><Q><G><A><V><K><A><V><A><W><C><P><W><Q><S><N><V><L><A><T><G><G><G><T><S><D><R><H><I><R><I><W><N><V><C><S><G><A><C><L><S><A><V><D><A><H><S><Q><V><C><S><I><L><W><S><P><H><Y><K><E><L><I><S><G><H><G><F><A><Q><N><Q><L><V><I><W><K><Y><P><T><M><A><K><V><A><E><L><K><G><H><T><S><R><V><L><S><L><T><M><S><P><D><G><A><T><V><A><S><A><A><A><D><E><T><L><R><L><W><R><C><F><E><L><D><P><A><R><R><R><E><R><E><K><A><S><A><A><K><S><S><L><I><H><Q><G><I><R> | Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.<BOP> | Q12834 |
Q96MK3 | FA20A_HUMAN | Pseudokinase FAM20A | Homo | <M><P><G><L><R><R><D><R><L><L><T><L><L><L><L><G><A><L><L><S><A><D><L><Y><F><H><L><W><P><Q><V><Q><R><Q><L><R><P><R><E><R><P><R><G><C><P><C><T><G><R><A><S><S><L><A><R><D><S><A><A><A><A><S><D><P><G><T><I><V><H><N><F><S><R><T><E><P><R><T><E><P><A><G><G><S><H><S><G><S><S><S><K><L><Q><A><L><F><A><H><P><L><Y><N><V><P><E><E><P><P><L><L><G><A><E><D><S><L><L><A><S><Q><E><A><L><R><Y><Y><R><R><K><V><A><R><W><N><R><R><H><K><M><Y><R><E><Q><M><N><L><T><S><L><D><P><P><L><Q><L><R><L><E><A><S><W><V><Q><F><H><L><G><I><N><R><H><G><L><Y><S><R><S><S><P><V><V><S><K><L><L><Q><D><M><R><H><F><P><T><I><S><A><D><Y><S><Q><D><E><K><A><L><L><G><A><C><D><C><T><Q><I><V><K><P><S><G><V><H><L><K><L><V><L><R><F><S><D><F><G><K><A><M><F><K><P><M><R><Q><Q><R><D><E><E><T><P><V><D><F><F><Y><F><I><D><F><Q><R><H><N><A><E><I><A><A><F><H><L><D><R><I><L><D><F><R><R><V><P><P><T><V><G><R><I><V><N><V><T><K><E><I><L><E><V><T><K><N><E><I><L><Q><S><V><F><F><V><S><P><A><S><N><V><C><F><F><A><K><C><P><Y><M><C><K><T><E><Y><A><V><C><G><N><P><H><L><L><E><G><S><L><S><A><F><L><P><S><L><N><L><A><P><R><L><S><V><P><N><P><W><I><R><S><Y><T><L><A><G><K><E><E><W><E><V><N><P><L><Y><C><D><T><V><K><Q><I><Y><P><Y><N><N><S><Q><R><L><L><N><V><I><D><M><A><I><F><D><F><L><I><G><N><M><D><R><H><H><Y><E><M><F><T><K><F><G><D><D><G><F><L><I><H><L><D><N><A><R><G><F><G><R><H><S><H><D><E><I><S><I><L><S><P><L><S><Q><C><C><M><I><K><K><K><T><L><L><H><L><Q><L><L><A><Q><A><D><Y><R><L><S><D><V><M><R><E><S><L><L><E><D><Q><L><S><P><V><L><T><E><P><H><L><L><A><L><D><R><R><L><Q><T><I><L><R><T><V><E><G><C><I><V><A><H><G><Q><Q><S><V><I><V><D><G><P><V><E><Q><L><A><P><D><S><G><Q><A><N><L><T><S> | Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals.<BOP> | Q96MK3 |
Q08380 | LG3BP_HUMAN | Tumor-associated antigen 90K | Homo | <M><T><P><P><R><L><F><W><V><W><L><L><V><A><G><T><Q><G><V><N><D><G><D><M><R><L><A><D><G><G><A><T><N><Q><G><R><V><E><I><F><Y><R><G><Q><W><G><T><V><C><D><N><L><W><D><L><T><D><A><S><V><V><C><R><A><L><G><F><E><N><A><T><Q><A><L><G><R><A><A><F><G><Q><G><S><G><P><I><M><L><D><E><V><Q><C><T><G><T><E><A><S><L><A><D><C><K><S><L><G><W><L><K><S><N><C><R><H><E><R><D><A><G><V><V><C><T><N><E><T><R><S><T><H><T><L><D><L><S><R><E><L><S><E><A><L><G><Q><I><F><D><S><Q><R><G><C><D><L><S><I><S><V><N><V><Q><G><E><D><A><L><G><F><C><G><H><T><V><I><L><T><A><N><L><E><A><Q><A><L><W><K><E><P><G><S><N><V><T><M><S><V><D><A><E><C><V><P><M><V><R><D><L><L><R><Y><F><Y><S><R><R><I><D><I><T><L><S><S><V><K><C><F><H><K><L><A><S><A><Y><G><A><R><Q><L><Q><G><Y><C><A><S><L><F><A><I><L><L><P><Q><D><P><S><F><Q><M><P><L><D><L><Y><A><Y><A><V><A><T><G><D><A><L><L><E><K><L><C><L><Q><F><L><A><W><N><F><E><A><L><T><Q><A><E><A><W><P><S><V><P><T><D><L><L><Q><L><L><L><P><R><S><D><L><A><V><P><S><E><L><A><L><L><K><A><V><D><T><W><S><W><G><E><R><A><S><H><E><E><V><E><G><L><V><E><K><I><R><F><P><M><M><L><P><E><E><L><F><E><L><Q><F><N><L><S><L><Y><W><S><H><E><A><L><F><Q><K><K><T><L><Q><A><L><E><F><H><T><V><P><F><Q><L><L><A><R><Y><K><G><L><N><L><T><E><D><T><Y><K><P><R><I><Y><T><S><P><T><W><S><A><F><V><T><D><S><S><W><S><A><R><K><S><Q><L><V><Y><Q><S><R><R><G><P><L><V><K><Y><S><S><D><Y><F><Q><A><P><S><D><Y><R><Y><Y><P><Y><Q><S><F><Q><T><P><Q><H><P><S><F><L><F><Q><D><K><R><V><S><W><S><L><V><Y><L><P><T><I><Q><S><C><W><N><Y><G><F><S><C><S><S><D><E><L><P><V><L><G><L><T><K><S><G><G><S><D><R><T><I><A><Y><E><N><K><A><L><M><L><C><E><G><L><F><V><A><D><V><T><D><F><E><G><W><K><A><A><I><P><S><A><L><D><T><N><S><S><K><S><T><S><S><F><P><C><P><A><G><H><F><N><G><F><R><T><V><I><R><P><F><Y><L><T><N><S><S><G><V><D> | Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.<BOP> | Q08380 |
Q9H4F8 | SMOC1_HUMAN | Secreted modular calcium-binding protein 1 | Homo | <M><L><P><A><R><C><A><R><L><L><T><P><H><L><L><L><V><L><V><Q><L><S><P><A><R><G><H><R><T><T><G><P><R><F><L><I><S><D><R><D><P><Q><C><N><L><H><C><S><R><T><Q><P><K><P><I><C><A><S><D><G><R><S><Y><E><S><M><C><E><Y><Q><R><A><K><C><R><D><P><T><L><G><V><V><H><R><G><R><C><K><D><A><G><Q><S><K><C><R><L><E><R><A><Q><A><L><E><Q><A><K><K><P><Q><E><A><V><F><V><P><E><C><G><E><D><G><S><F><T><Q><V><Q><C><H><T><Y><T><G><Y><C><W><C><V><T><P><D><G><K><P><I><S><G><S><S><V><Q><N><K><T><P><V><C><S><G><S><V><T><D><K><P><L><S><Q><G><N><S><G><R><K><D><D><G><S><K><P><T><P><T><M><E><T><Q><P><V><F><D><G><D><E><I><T><A><P><T><L><W><I><K><H><L><V><I><K><D><S><K><L><N><N><T><N><I><R><N><S><E><K><V><Y><S><C><D><Q><E><R><Q><S><A><L><E><E><A><Q><Q><N><P><R><E><G><I><V><I><P><E><C><A><P><G><G><L><Y><K><P><V><Q><C><H><Q><S><T><G><Y><C><W><C><V><L><V><D><T><G><R><P><L><P><G><T><S><T><R><Y><V><M><P><S><C><E><S><D><A><R><A><K><T><T><E><A><D><D><P><F><K><D><R><E><L><P><G><C><P><E><G><K><K><M><E><F><I><T><S><L><L><D><A><L><T><T><D><M><V><Q><A><I><N><S><A><A><P><T><G><G><G><R><F><S><E><P><D><P><S><H><T><L><E><E><R><V><V><H><W><Y><F><S><Q><L><D><S><N><S><S><N><D><I><N><K><R><E><M><K><P><F><K><R><Y><V><K><K><K><A><K><P><K><K><C><A><R><R><F><T><D><Y><C><D><L><N><K><D><K><V><I><S><L><P><E><L><K><G><C><L><G><V><S><K><E><G><R><L><V> | Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.<BOP> | Q9H4F8 |
Q9BQP7 | MGME1_HUMAN | Mitochondrial genome maintenance exonuclease 1 | Homo | <M><K><M><K><L><F><Q><T><I><C><R><Q><L><R><S><S><K><F><S><V><E><S><A><A><L><V><A><F><S><T><S><S><Y><S><C><G><R><K><K><K><V><N><P><Y><E><E><V><D><Q><E><K><Y><S><N><L><V><Q><S><V><L><S><S><R><G><V><A><Q><T><P><G><S><V><E><E><D><A><L><L><C><G><P><V><S><K><H><K><L><P><N><Q><G><E><D><R><R><V><P><Q><N><W><F><P><I><F><N><P><E><R><S><D><K><P><N><A><S><D><P><S><V><P><L><K><I><P><L><Q><R><N><V><I><P><S><V><T><R><V><L><Q><Q><T><M><T><K><Q><Q><V><F><L><L><E><R><W><K><Q><R><M><I><L><E><L><G><E><D><G><F><K><E><Y><T><S><N><V><F><L><Q><G><K><R><F><H><E><A><L><E><S><I><L><S><P><Q><E><T><L><K><E><R><D><E><N><L><L><K><S><G><Y><I><E><S><V><Q><H><I><L><K><D><V><S><G><V><R><A><L><E><S><A><V><Q><H><E><T><L><N><Y><I><G><L><L><D><C><V><A><E><Y><Q><G><K><L><C><V><I><D><W><K><T><S><E><K><P><K><P><F><I><Q><S><T><F><D><N><P><L><Q><V><V><A><Y><M><G><A><M><N><H><D><T><N><Y><S><F><Q><V><Q><C><G><L><I><V><V><A><Y><K><D><G><S><P><A><H><P><H><F><M><D><A><E><L><C><S><Q><Y><W><T><K><W><L><L><R><L><E><E><Y><T><E><K><K><K><N><Q><N><I><Q><K><P><E><Y><S><E> | Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.<BOP> | Q9BQP7 |
P05111 | INHA_HUMAN | Inhibin alpha chain | Homo | <M><V><L><H><L><L><L><F><L><L><L><T><P><Q><G><G><H><S><C><Q><G><L><E><L><A><R><E><L><V><L><A><K><V><R><A><L><F><L><D><A><L><G><P><P><A><V><T><R><E><G><G><D><P><G><V><R><R><L><P><R><R><H><A><L><G><G><F><T><H><R><G><S><E><P><E><E><E><E><D><V><S><Q><A><I><L><F><P><A><T><D><A><S><C><E><D><K><S><A><A><R><G><L><A><Q><E><A><E><E><G><L><F><R><Y><M><F><R><P><S><Q><H><T><R><S><R><Q><V><T><S><A><Q><L><W><F><H><T><G><L><D><R><Q><G><T><A><A><S><N><S><S><E><P><L><L><G><L><L><A><L><S><P><G><G><P><V><A><V><P><M><S><L><G><H><A><P><P><H><W><A><V><L><H><L><A><T><S><A><L><S><L><L><T><H><P><V><L><V><L><L><L><R><C><P><L><C><T><C><S><A><R><P><E><A><T><P><F><L><V><A><H><T><R><T><R><P><P><S><G><G><E><R><A><R><R><S><T><P><L><M><S><W><P><W><S><P><S><A><L><R><L><L><Q><R><P><P><E><E><P><A><A><H><A><N><C><H><R><V><A><L><N><I><S><F><Q><E><L><G><W><E><R><W><I><V><Y><P><P><S><F><I><F><H><Y><C><H><G><G><C><G><L><H><I><P><P><N><L><S><L><P><V><P><G><A><P><P><T><P><A><Q><P><Y><S><L><L><P><G><A><Q><P><C><C><A><A><L><P><G><T><M><R><P><L><H><V><R><T><T><S><D><G><G><Y><S><F><K><Y><E><T><V><P><N><L><L><T><Q><H><C><A><C><I> | Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.<BOP> | P05111 |
Q9NPG2 | NGB_HUMAN | Neuroglobin | Homo | <M><E><R><P><E><P><E><L><I><R><Q><S><W><R><A><V><S><R><S><P><L><E><H><G><T><V><L><F><A><R><L><F><A><L><E><P><D><L><L><P><L><F><Q><Y><N><C><R><Q><F><S><S><P><E><D><C><L><S><S><P><E><F><L><D><H><I><R><K><V><M><L><V><I><D><A><A><V><T><N><V><E><D><L><S><S><L><E><E><Y><L><A><S><L><G><R><K><H><R><A><V><G><V><K><L><S><S><F><S><T><V><G><E><S><L><L><Y><M><L><E><K><C><L><G><P><A><F><T><P><A><T><R><A><A><W><S><Q><L><Y><G><A><V><V><Q><A><M><S><R><G><W><D><G><E> | Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<BOP> | Q9NPG2 |
P02675 | FIBB_HUMAN | Fibrinogen beta chain | Homo | <M><K><R><M><V><S><W><S><F><H><K><L><K><T><M><K><H><L><L><L><L><L><L><C><V><F><L><V><K><S><Q><G><V><N><D><N><E><E><G><F><F><S><A><R><G><H><R><P><L><D><K><K><R><E><E><A><P><S><L><R><P><A><P><P><P><I><S><G><G><G><Y><R><A><R><P><A><K><A><A><A><T><Q><K><K><V><E><R><K><A><P><D><A><G><G><C><L><H><A><D><P><D><L><G><V><L><C><P><T><G><C><Q><L><Q><E><A><L><L><Q><Q><E><R><P><I><R><N><S><V><D><E><L><N><N><N><V><E><A><V><S><Q><T><S><S><S><S><F><Q><Y><M><Y><L><L><K><D><L><W><Q><K><R><Q><K><Q><V><K><D><N><E><N><V><V><N><E><Y><S><S><E><L><E><K><H><Q><L><Y><I><D><E><T><V><N><S><N><I><P><T><N><L><R><V><L><R><S><I><L><E><N><L><R><S><K><I><Q><K><L><E><S><D><V><S><A><Q><M><E><Y><C><R><T><P><C><T><V><S><C><N><I><P><V><V><S><G><K><E><C><E><E><I><I><R><K><G><G><E><T><S><E><M><Y><L><I><Q><P><D><S><S><V><K><P><Y><R><V><Y><C><D><M><N><T><E><N><G><G><W><T><V><I><Q><N><R><Q><D><G><S><V><D><F><G><R><K><W><D><P><Y><K><Q><G><F><G><N><V><A><T><N><T><D><G><K><N><Y><C><G><L><P><G><E><Y><W><L><G><N><D><K><I><S><Q><L><T><R><M><G><P><T><E><L><L><I><E><M><E><D><W><K><G><D><K><V><K><A><H><Y><G><G><F><T><V><Q><N><E><A><N><K><Y><Q><I><S><V><N><K><Y><R><G><T><A><G><N><A><L><M><D><G><A><S><Q><L><M><G><E><N><R><T><M><T><I><H><N><G><M><F><F><S><T><Y><D><R><D><N><D><G><W><L><T><S><D><P><R><K><Q><C><S><K><E><D><G><G><G><W><W><Y><N><R><C><H><A><A><N><P><N><G><R><Y><Y><W><G><G><Q><Y><T><W><D><M><A><K><H><G><T><D><D><G><V><V><W><M><N><W><K><G><S><W><Y><S><M><R><K><M><S><M><K><I><R><P><F><F><P><Q><Q> | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.<BOP> | P02675 |
Q7Z4W3 | KR193_HUMAN | Glycine/tyrosine-rich protein | Homo | <M><S><Y><Y><G><S><Y><Y><G><G><L><G><Y><G><C><G><G><F><G><G><L><G><Y><G><Y><G><C><G><C><G><S><F><R><R><L><G><S><G><C><G><Y><G><G><Y><G><Y><G><S><G><F><G><G><Y><G><Y><G><S><G><F><G><G><Y><G><Y><G><C><Y><R><P><S><Y><Y><G><G><Y><G><F><S><G><F><Y> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | Q7Z4W3 |
Q04741 | EMX1_HUMAN | Empty spiracles-like protein 1 | Homo | <M><C><L><A><G><C><T><P><R><K><A><A><A><P><G><R><G><A><L><P><R><A><R><L><P><R><T><A><P><A><A><A><T><M><F><Q><P><A><A><K><R><G><F><T><I><E><S><L><V><A><K><D><G><G><T><G><G><G><T><G><G><G><G><A><G><S><H><L><L><A><A><A><A><S><E><E><P><L><R><P><T><A><L><N><Y><P><H><P><S><A><A><E><A><A><F><V><S><G><F><P><A><A><A><A><A><G><A><G><R><S><L><Y><G><G><P><E><L><V><F><P><E><A><M><N><H><P><A><L><T><V><H><P><A><H><Q><L><G><A><S><P><L><Q><P><P><H><S><F><F><G><A><Q><H><R><D><P><L><H><F><Y><P><W><V><L><R><N><R><F><F><G><H><R><F><Q><A><S><D><V><P><Q><D><G><L><L><L><H><G><P><F><A><R><K><P><K><R><I><R><T><A><F><S><P><S><Q><L><L><R><L><E><R><A><F><E><K><N><H><Y><V><V><G><A><E><R><K><Q><L><A><G><S><L><S><L><S><E><T><Q><V><K><V><W><F><Q><N><R><R><T><K><Y><K><R><Q><K><L><E><E><E><G><P><E><S><E><Q><K><K><K><G><S><H><H><I><N><R><W><R><I><A><T><K><Q><A><N><G><E><D><I><D><V><T><S><N><D> | Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.<BOP> | Q04741 |
Q8N8L2 | ZN491_HUMAN | Zinc finger protein 491 | Homo | <M><G><E><R><L><F><E><S><A><E><G><S><Q><C><G><E><T><F><T><Q><V><P><E><D><M><L><N><K><K><T><L><P><G><V><K><S><C><E><S><G><T><C><G><E><I><F><M><G><Y><S><S><F><N><R><N><I><R><T><D><T><G><H><Q><P><H><K><C><Q><K><F><L><E><K><P><Y><K><H><K><Q><R><R><K><A><L><S><H><S><H><C><F><R><T><H><E><R><P><H><T><R><E><K><P><F><D><C><K><E><C><E><K><S><F><I><S><P><A><S><I><R><R><Y><M><V><T><H><S><G><D><G><P><Y><K><C><K><F><C><G><K><A><L><D><C><L><S><L><Y><L><T><H><E><R><T><H><T><G><E><K><R><Y><E><C><K><Q><C><G><K><A><F><S><W><H><S><S><V><R><I><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><S><F><N><F><S><S><S><F><R><R><H><E><R><T><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><N><C><P><S><S><F><H><R><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><L><Y><G><K><A><L><S><R><L><I><S><F><R><R><H><M><R><M><H><T><G><E><R><P><H><K><C><K><I><C><G><K><A><F><Y><S><P><S><S><F><Q><R><H><E><R><S><H><T><G><E><K><P><Y><K><C><K><Q><C><G><K><A><F><T><C><S><T><S><F><Q><Y><H><E><R><T><H><T><G><E><K><P><D><G><C><K><Q><C><G><K><A><F><R><S><A><K><Y><I><R><I><H><G><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><H><C><V><S><S><F><H><R><H><E><R><T><H><A><G><E><K><P><Y><E><C><K><H><C><G><K><A><F><T><C><S><I><Y><I><R><I><H><E><R><I><H><T><G><E><K><P><Y><Q><C><K><E><C><G><K><A><F><I><R><S><S><Y><C><R><K><H><E><R><T><H><T><I><N><I> | May be involved in transcriptional regulation.<BOP> | Q8N8L2 |
P26599 | PTBP1_HUMAN | Heterogeneous nuclear ribonucleoprotein I | Homo | <M><D><G><I><V><P><D><I><A><V><G><T><K><R><G><S><D><E><L><F><S><T><C><V><T><N><G><P><F><I><M><S><S><N><S><A><S><A><A><N><G><N><D><S><K><K><F><K><G><D><S><R><S><A><G><V><P><S><R><V><I><H><I><R><K><L><P><I><D><V><T><E><G><E><V><I><S><L><G><L><P><F><G><K><V><T><N><L><L><M><L><K><G><K><N><Q><A><F><I><E><M><N><T><E><E><A><A><N><T><M><V><N><Y><Y><T><S><V><T><P><V><L><R><G><Q><P><I><Y><I><Q><F><S><N><H><K><E><L><K><T><D><S><S><P><N><Q><A><R><A><Q><A><A><L><Q><A><V><N><S><V><Q><S><G><N><L><A><L><A><A><S><A><A><A><V><D><A><G><M><A><M><A><G><Q><S><P><V><L><R><I><I><V><E><N><L><F><Y><P><V><T><L><D><V><L><H><Q><I><F><S><K><F><G><T><V><L><K><I><I><T><F><T><K><N><N><Q><F><Q><A><L><L><Q><Y><A><D><P><V><S><A><Q><H><A><K><L><S><L><D><G><Q><N><I><Y><N><A><C><C><T><L><R><I><D><F><S><K><L><T><S><L><N><V><K><Y><N><N><D><K><S><R><D><Y><T><R><P><D><L><P><S><G><D><S><Q><P><S><L><D><Q><T><M><A><A><A><F><G><A><P><G><I><I><S><A><S><P><Y><A><G><A><G><F><P><P><T><F><A><I><P><Q><A><A><G><L><S><V><P><N><V><H><G><A><L><A><P><L><A><I><P><S><A><A><A><A><A><A><A><A><G><R><I><A><I><P><G><L><A><G><A><G><N><S><V><L><L><V><S><N><L><N><P><E><R><V><T><P><Q><S><L><F><I><L><F><G><V><Y><G><D><V><Q><R><V><K><I><L><F><N><K><K><E><N><A><L><V><Q><M><A><D><G><N><Q><A><Q><L><A><M><S><H><L><N><G><H><K><L><H><G><K><P><I><R><I><T><L><S><K><H><Q><N><V><Q><L><P><R><E><G><Q><E><D><Q><G><L><T><K><D><Y><G><N><S><P><L><H><R><F><K><K><P><G><S><K><N><F><Q><N><I><F><P><P><S><A><T><L><H><L><S><N><I><P><P><S><V><S><E><E><D><L><K><V><L><F><S><S><N><G><G><V><V><K><G><F><K><F><F><Q><K><D><R><K><M><A><L><I><Q><M><G><S><V><E><E><A><V><Q><A><L><I><D><L><H><N><H><D><L><G><E><N><H><H><L><R><V><S><F><S><K><S><T><I> | Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 . Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9 . Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform . In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES | P26599 |
P47224 | MSS4_HUMAN | Rab-interacting factor | Homo | <M><E><P><A><E><Q><P><S><E><L><V><S><A><E><G><R><N><R><K><A><V><L><C><Q><R><C><G><S><R><V><L><Q><P><G><T><A><L><F><S><R><R><Q><L><F><L><P><S><M><R><K><K><P><A><L><S><D><G><S><N><P><D><G><D><L><L><Q><E><H><W><L><V><E><D><M><F><I><F><E><N><V><G><F><T><K><D><V><G><N><I><K><F><L><V><C><A><D><C><E><I><G><P><I><G><W><H><C><L><D><D><K><N><S><F><Y><V><A><L><E><R><V><S><H><E> | Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1, RAB3A and RAB10, but is less active on these proteins than on the SEC4 protein . Might play a general role in vesicular transport.<BOP> | P47224 |
Q5JPI9 | EFMT2_HUMAN | Protein-lysine N-methyltransferase METTL10 | Homo | <M><S><S><G><A><D><G><G><G><G><A><A><V><A><A><R><S><D><K><G><S><P><G><E><D><G><F><V><P><S><A><L><G><T><R><E><H><W><D><A><V><Y><E><R><E><L><Q><T><F><R><E><Y><G><D><T><G><E><I><W><F><G><E><E><S><M><N><R><L><I><R><W><M><Q><K><H><K><I><P><L><D><A><S><V><L><D><I><G><T><G><N><G><V><F><L><V><E><L><A><K><F><G><F><S><N><I><T><G><I><D><Y><S><P><S><A><I><Q><L><S><G><S><I><I><E><K><E><G><L><S><N><I><K><L><K><V><E><D><F><L><N><L><S><T><Q><L><S><G><F><H><I><C><I><D><K><G><T><F><D><A><I><S><L><N><P><D><N><A><I><E><K><R><K><Q><Y><V><K><S><L><S><R><V><L><K><V><K><G><F><F><L><I><T><S><C><N><W><T><K><E><E><L><L><N><E><F><S><E><G><W><S><T><V><A><G><F><W><L><T><A><A><L><T><S><W><A><Q><A><I><F><S><T><S><A><S><R><V><G><G><T><T><G><T><H><H><H><A><W><I><I><F><V><F><L><A><E><T><R><F><C><H><V><V><Q><A><G><L><E><L><L><G><S><S><D><S><P><T><W><P><P><K><V><L><G><L><Y><H><A><R><P><S><L><A><F> | Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.<BOP> | Q5JPI9 |
P11766 | ADHX_HUMAN | S-(hydroxymethyl)glutathione dehydrogenase | Homo | <M><A><N><E><V><I><K><C><K><A><A><V><A><W><E><A><G><K><P><L><S><I><E><E><I><E><V><A><P><P><K><A><H><E><V><R><I><K><I><I><A><T><A><V><C><H><T><D><A><Y><T><L><S><G><A><D><P><E><G><C><F><P><V><I><L><G><H><E><G><A><G><I><V><E><S><V><G><E><G><V><T><K><L><K><A><G><D><T><V><I><P><L><Y><I><P><Q><C><G><E><C><K><F><C><L><N><P><K><T><N><L><C><Q><K><I><R><V><T><Q><G><K><G><L><M><P><D><G><T><S><R><F><T><C><K><G><K><T><I><L><H><Y><M><G><T><S><T><F><S><E><Y><T><V><V><A><D><I><S><V><A><K><I><D><P><L><A><P><L><D><K><V><C><L><L><G><C><G><I><S><T><G><Y><G><A><A><V><N><T><A><K><L><E><P><G><S><V><C><A><V><F><G><L><G><G><V><G><L><A><V><I><M><G><C><K><V><A><G><A><S><R><I><I><G><V><D><I><N><K><D><K><F><A><R><A><K><E><F><G><A><T><E><C><I><N><P><Q><D><F><S><K><P><I><Q><E><V><L><I><E><M><T><D><G><G><V><D><Y><S><F><E><C><I><G><N><V><K><V><M><R><A><A><L><E><A><C><H><K><G><W><G><V><S><V><V><V><G><V><A><A><S><G><E><E><I><A><T><R><P><F><Q><L><V><T><G><R><T><W><K><G><T><A><F><G><G><W><K><S><V><E><S><V><P><K><L><V><S><E><Y><M><S><K><K><I><K><V><D><E><F><V><T><H><N><L><S><F><D><E><I><N><K><A><F><E><L><M><H><S><G><K><S><I><R><T><V><V><K><I> | Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione . Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate . Class-III ADH is remarkably ineffective in oxidizing ethanol . Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage .<BOP> | P11766 |
Q9H7C4 | SYNCI_HUMAN | Syncoilin-1 | Homo | <M><A><S><P><E><P><R><R><G><G><D><G><A><A><Q><A><A><R><K><T><R><V><E><A><N><S><P><L><P><K><N><S><G><S><L><N><E><A><E><A><L><N><P><E><V><T><L><S><S><E><G><S><L><N><L><E><D><I><L><Y><L><E><D><T><G><D><L><D><E><T><L><Y><V><Q><E><T><E><K><A><E><E><A><L><Y><I><E><E><A><M><Q><P><D><E><A><L><H><V><E><E><P><G><N><P><E><E><T><V><C><V><E><E><T><T><E><P><D><R><I><Q><F><V><E><G><P><V><E><P><G><K><P><T><S><P><E><H><V><V><Y><E><G><E><T><V><T><R><A><E><K><S><N><P><E><E><S><L><R><A><E><Q><S><P><S><M><E><E><N><L><S><I><E><D><L><E><L><L><E><G><R><F><Q><Q><C><V><Q><A><V><A><Q><L><E><E><E><R><D><Q><L><I><H><E><L><V><L><L><R><E><P><A><L><Q><E><V><Q><Q><V><H><Q><D><I><L><A><A><Y><K><L><H><A><Q><A><E><L><E><R><D><G><L><R><E><E><I><R><L><V><K><Q><K><L><F><K><V><T><K><E><C><V><A><Y><Q><Y><Q><L><E><C><R><Q><Q><D><V><A><Q><F><A><D><F><R><E><V><L><T><T><R><A><T><Q><L><S><E><E><L><A><Q><L><R><D><A><Y><Q><K><Q><K><E><Q><L><R><Q><Q><L><E><A><P><P><S><Q><R><D><G><H><F><L><Q><E><S><R><R><L><S><A><Q><F><E><N><L><M><A><E><S><R><Q><D><L><E><E><E><Y><E><P><Q><F><L><R><L><L><E><R><K><E><A><G><T><K><A><L><Q><R><T><Q><A><E><I><Q><E><M><K><E><A><L><R><P><L><Q><A><E><A><R><Q><L><R><L><Q><N><R><N><L><E><D><Q><I><A><L><V><R><Q><K><R><D><E><E><V><Q><Q><Y><R><E><Q><L><E><E><M><E><E><R><Q><R><Q><L><R><N><G><V><Q><L><Q><Q><Q><K><N><K><E><M><E><Q><L><R><L><S><L><A><E><E><L><S><T><Y><K><A><M><L><L><P><K><S><L><E><Q><A><D><A><P><T><S><Q><A><G><G><M><E><T><Q><S><Q><G><A><V> | Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins.<BOP> | Q9H7C4 |
P30613 | KPYR_HUMAN | Red cell/liver pyruvate kinase | Homo | <M><S><I><Q><E><N><I><S><S><L><Q><L><R><S><W><V><S><K><S><Q><R><D><L><A><K><S><I><L><I><G><A><P><G><G><P><A><G><Y><L><R><R><A><S><V><A><Q><L><T><Q><E><L><G><T><A><F><F><Q><Q><Q><Q><L><P><A><A><M><A><D><T><F><L><E><H><L><C><L><L><D><I><D><S><E><P><V><A><A><R><S><T><S><I><I><A><T><I><G><P><A><S><R><S><V><E><R><L><K><E><M><I><K><A><G><M><N><I><A><R><L><N><F><S><H><G><S><H><E><Y><H><A><E><S><I><A><N><V><R><E><A><V><E><S><F><A><G><S><P><L><S><Y><R><P><V><A><I><A><L><D><T><K><G><P><E><I><R><T><G><I><L><Q><G><G><P><E><S><E><V><E><L><V><K><G><S><Q><V><L><V><T><V><D><P><A><F><R><T><R><G><N><A><N><T><V><W><V><D><Y><P><N><I><V><R><V><V><P><V><G><G><R><I><Y><I><D><D><G><L><I><S><L><V><V><Q><K><I><G><P><E><G><L><V><T><Q><V><E><N><G><G><V><L><G><S><R><K><G><V><N><L><P><G><A><Q><V><D><L><P><G><L><S><E><Q><D><V><R><D><L><R><F><G><V><E><H><G><V><D><I><V><F><A><S><F><V><R><K><A><S><D><V><A><A><V><R><A><A><L><G><P><E><G><H><G><I><K><I><I><S><K><I><E><N><H><E><G><V><K><R><F><D><E><I><L><E><V><S><D><G><I><M><V><A><R><G><D><L><G><I><E><I><P><A><E><K><V><F><L><A><Q><K><M><M><I><G><R><C><N><L><A><G><K><P><V><V><C><A><T><Q><M><L><E><S><M><I><T><K><P><R><P><T><R><A><E><T><S><D><V><A><N><A><V><L><D><G><A><D><C><I><M><L><S><G><E><T><A><K><G><N><F><P><V><E><A><V><K><M><Q><H><A><I><A><R><E><A><E><A><A><V><Y><H><R><Q><L><F><E><E><L><R><R><A><A><P><L><S><R><D><P><T><E><V><T><A><I><G><A><V><E><A><A><F><K><C><C><A><A><A><I><I><V><L><T><T><T><G><R><S><A><Q><L><L><S><R><Y><R><P><R><A><A><V><I><A><V><T><R><S><A><Q><A><A><R><Q><V><H><L><C><R><G><V><F><P><L><L><Y><R><E><P><P><E><A><I><W><A><D><D><V><D><R><R><V><Q><F><G><I><E><S><G><K><L><R><G><F><L><R><V><G><D><L><V><I><V><V><T><G><W><R><P><G><S><G><Y><T><N><I><M><R><V><L><S><I><S> | Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis.<BOP> | P30613 |
Q8NG97 | OR2Z1_HUMAN | Olfactory receptor OR19-4 | Homo | <M><G><D><V><N><Q><S><V><A><S><D><F><I><L><V><G><L><F><S><H><S><G><S><R><Q><L><L><F><S><L><V><A><V><M><F><V><I><G><L><L><G><N><T><V><L><L><F><L><I><R><V><D><S><R><L><H><T><P><M><Y><F><L><L><S><Q><L><S><L><F><D><I><G><C><P><M><V><T><I><P><K><M><A><S><D><F><L><R><G><E><G><A><T><S><Y><G><G><G><A><A><Q><I><F><F><L><T><L><M><G><V><A><E><G><V><L><L><V><L><M><S><Y><D><R><Y><V><A><V><C><Q><P><L><Q><Y><P><V><L><M><R><R><Q><V><C><L><L><M><M><G><S><S><W><V><V><G><V><L><N><A><S><I><Q><T><S><I><T><L><H><F><P><Y><C><A><S><R><I><V><D><H><F><F><C><E><V><P><A><L><L><K><L><S><C><A><D><T><C><A><Y><E><M><A><L><S><T><S><G><V><L><I><L><M><L><P><L><S><L><I><A><T><S><Y><G><H><V><L><Q><A><V><L><S><M><R><S><E><E><A><R><H><K><A><V><T><T><C><S><S><H><I><T><V><V><G><L><F><Y><G><A><A><V><F><M><Y><M><V><P><C><A><Y><H><S><P><Q><Q><D><N><V><V><S><L><F><Y><S><L><V><T><P><T><L><N><P><L><I><Y><S><L><R><N><P><E><V><W><M><A><L><V><K><V><L><S><R><A><G><L><R><Q><M><C> | Odorant receptor.<BOP> | Q8NG97 |
Q96CX3 | ZN501_HUMAN | Zinc finger protein 52 | Homo | <M><N><S><S><Q><I><S><L><R><M><K><H><G><R><V><N><M><Q><K><K><P><S><K><C><S><E><C><G><K><F><F><T><Q><R><S><S><L><T><Q><H><Q><R><I><H><R><G><E><K><P><Y><V><C><S><E><C><G><S><C><F><R><K><Q><S><N><L><T><Q><H><L><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><E><K><A><F><Q><T><K><A><I><L><V><Q><H><L><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><C><Q><S><P><S><L><I><K><H><Q><R><I><H><T><G><E><K><P><Y><K><C><T><E><C><G><K><A><F><S><Q><S><I><C><L><T><R><H><Q><R><S><H><S><G><D><K><P><F><K><C><N><E><C><G><K><A><F><N><Q><S><A><C><L><M><Q><H><Q><R><I><H><S><G><E><K><P><Y><T><C><T><E><C><G><K><A><F><T><Q><N><S><S><L><V><E><H><E><R><T><H><T><G><E><K><L><Y><K><C><S><E><C><E><K><T><F><R><K><Q><A><H><L><S><E><H><Y><R><I><H><T><G><E><K><P><Y><E><C><V><G><C><G><K><S><F><R><H><S><S><A><L><L><R><H><Q><R><L><H><A><G><E> | May be involved in transcriptional regulation. Essential for Golgi structural integrity .<BOP> | Q96CX3 |
Q8IU57 | INLR1_HUMAN | Likely interleukin or cytokine receptor 2 | Homo | <M><A><G><P><E><R><W><G><P><L><L><L><C><L><L><Q><A><A><P><G><R><P><R><L><A><P><P><Q><N><V><T><L><L><S><Q><N><F><S><V><Y><L><T><W><L><P><G><L><G><N><P><Q><D><V><T><Y><F><V><A><Y><Q><S><S><P><T><R><R><R><W><R><E><V><E><E><C><A><G><T><K><E><L><L><C><S><M><M><C><L><K><K><Q><D><L><Y><N><K><F><K><G><R><V><R><T><V><S><P><S><S><K><S><P><W><V><E><S><E><Y><L><D><Y><L><F><E><V><E><P><A><P><P><V><L><V><L><T><Q><T><E><E><I><L><S><A><N><A><T><Y><Q><L><P><P><C><M><P><P><L><D><L><K><Y><E><V><A><F><W><K><E><G><A><G><N><K><T><L><F><P><V><T><P><H><G><Q><P><V><Q><I><T><L><Q><P><A><A><S><E><H><H><C><L><S><A><R><T><I><Y><T><F><S><V><P><K><Y><S><K><F><S><K><P><T><C><F><L><L><E><V><P><E><A><N><W><A><F><L><V><L><P><S><L><L><I><L><L><L><V><I><A><A><G><G><V><I><W><K><T><L><M><G><N><P><W><F><Q><R><A><K><M><P><R><A><L><D><F><S><G><H><T><H><P><V><A><T><F><Q><P><S><R><P><E><S><V><N><D><L><F><L><C><P><Q><K><E><L><T><R><G><V><R><P><T><P><R><V><R><A><P><A><T><Q><Q><T><R><W><K><K><D><L><A><E><D><E><E><E><E><D><E><E><D><T><E><D><G><V><S><F><Q><P><Y><I><E><P><P><S><F><L><G><Q><E><H><Q><A><P><G><H><S><E><A><G><G><V><D><S><G><R><P><R><A><P><L><V><P><S><E><G><S><S><A><W><D><S><S><D><R><S><W><A><S><T><V><D><S><S><W><D><R><A><G><S><S><G><Y><L><A><E><K><G><P><G><Q><G><P><G><G><D><G><H><Q><E><S><L><P><P><P><E><F><S><K><D><S><G><F><L><E><E><L><P><E><D><N><L><S><S><W><A><T><W><G><T><L><P><P><E><P><N><L><V><P><G><G><P><P><V><S><L><Q><T><L><T><F><C><W><E><S><S><P><E><E><E><E><E><A><R><E><S><E><I><E><D><S><D><A><G><S><W><G><A><E><S><T><Q><R><T><E><D><R><G><R><T><L><G><H><Y><M><A><R> | The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.<BOP> | Q8IU57 |
Q6NT55 | CP4FN_HUMAN | Cytochrome P450 4F22 | Homo | <M><L><P><I><T><D><R><L><L><H><L><L><G><L><E><K><T><A><F><R><I><Y><A><V><S><T><L><L><L><F><L><L><F><F><L><F><R><L><L><L><R><F><L><R><L><C><R><S><F><Y><I><T><C><R><R><L><R><C><F><P><Q><P><P><R><R><N><W><L><L><G><H><L><G><M><Y><L><P><N><E><A><G><L><Q><D><E><K><K><V><L><D><N><M><H><H><V><L><L><V><W><M><G><P><V><L><P><L><L><V><L><V><H><P><D><Y><I><K><P><L><L><G><A><S><A><A><I><A><P><K><D><D><L><F><Y><G><F><L><K><P><W><L><G><D><G><L><L><L><S><K><G><D><K><W><S><R><H><R><R><L><L><T><P><A><F><H><F><D><I><L><K><P><Y><M><K><I><F><N><Q><S><A><D><I><M><H><A><K><W><R><H><L><A><E><G><S><A><V><S><L><D><M><F><E><H><I><S><L><M><T><L><D><S><L><Q><K><C><V><F><S><Y><N><S><N><C><Q><E><K><M><S><D><Y><I><S><A><I><I><E><L><S><A><L><S><V><R><R><Q><Y><R><L><H><H><Y><L><D><F><I><Y><Y><R><S><A><D><G><R><R><F><R><Q><A><C><D><M><V><H><H><F><T><T><E><V><I><Q><E><R><R><R><A><L><R><Q><Q><G><A><E><A><W><L><K><A><K><Q><G><K><T><L><D><F><I><D><V><L><L><L><A><R><D><E><D><G><K><E><L><S><D><E><D><I><R><A><E><A><D><T><F><M><F><E><G><H><D><T><T><S><S><G><I><S><W><M><L><F><N><L><A><K><Y><P><E><Y><Q><E><K><C><R><E><E><I><Q><E><V><M><K><G><R><E><L><E><E><L><E><W><D><D><L><T><Q><L><P><F><T><T><M><C><I><K><E><S><L><R><Q><Y><P><P><V><T><L><V><S><R><Q><C><T><E><D><I><K><L><P><D><G><R><I><I><P><K><G><I><I><C><L><V><S><I><Y><G><T><H><H><N><P><T><V><W><P><D><S><K><V><Y><N><P><Y><R><F><D><P><D><N><P><Q><Q><R><S><P><L><A><Y><V><P><F><S><A><G><P><R><N><C><I><G><Q><S><F><A><M><A><E><L><R><V><V><V><A><L><T><L><L><R><F><R><L><S><V><D><R><T><R><K><V><R><R><K><P><E><L><I><L><R><T><E><N><G><L><W><L><K><V><E><P><L><P><P><R><A> | A cytochrome P450 monooxygenase involved in epidermal ceramide biosynthesis. Hydroxylates the terminal carbon (omega-hydroxylation) of ultra-long-chain fatty acyls (C28-C36) prior to ceramide synthesis . Contributes to the synthesis of three classes of omega-hydroxy-ultra-long chain fatty acylceramides having sphingosine, 6-hydroxysphingosine and phytosphingosine bases, all major lipid components that underlie the permeability barrier of the stratum corneum . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) .<BOP> | Q6NT55 |
Q8IZJ0 | IFNL2_HUMAN | Interleukin-28A | Homo | <M><K><L><D><M><T><G><D><C><T><P><V><L><V><L><M><A><A><V><L><T><V><T><G><A><V><P><V><A><R><L><H><G><A><L><P><D><A><R><G><C><H><I><A><Q><F><K><S><L><S><P><Q><E><L><Q><A><F><K><R><A><K><D><A><L><E><E><S><L><L><L><K><D><C><R><C><H><S><R><L><F><P><R><T><W><D><L><R><Q><L><Q><V><R><E><R><P><M><A><L><E><A><E><L><A><L><T><L><K><V><L><E><A><T><A><D><T><D><P><A><L><V><D><V><L><D><Q><P><L><H><T><L><H><H><I><L><S><Q><F><R><A><C><I><Q><P><Q><P><T><A><G><P><R><T><R><G><R><L><H><H><W><L><Y><R><L><Q><E><A><P><K><K><E><S><P><G><C><L><E><A><S><V><T><F><N><L><F><R><L><L><T><R><D><L><N><C><V><A><S><G><D><L><C><V> | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.<BOP> | Q8IZJ0 |
Q9Y394 | DHRS7_HUMAN | Short chain dehydrogenase/reductase family 34C member 1 | Homo | <M><N><W><E><L><L><L><W><L><L><V><L><C><A><L><L><L><L><L><V><Q><L><L><R><F><L><R><A><D><G><D><L><T><L><L><W><A><E><W><Q><G><R><R><P><E><W><E><L><T><D><M><V><V><W><V><T><G><A><S><S><G><I><G><E><E><L><A><Y><Q><L><S><K><L><G><V><S><L><V><L><S><A><R><R><V><H><E><L><E><R><V><K><R><R><C><L><E><N><G><N><L><K><E><K><D><I><L><V><L><P><L><D><L><T><D><T><G><S><H><E><A><A><T><K><A><V><L><Q><E><F><G><R><I><D><I><L><V><N><N><G><G><M><S><Q><R><S><L><C><M><D><T><S><L><D><V><Y><R><K><L><I><E><L><N><Y><L><G><T><V><S><L><T><K><C><V><L><P><H><M><I><E><R><K><Q><G><K><I><V><T><V><N><S><I><L><G><I><I><S><V><P><L><S><I><G><Y><C><A><S><K><H><A><L><R><G><F><F><N><G><L><R><T><E><L><A><T><Y><P><G><I><I><V><S><N><I><C><P><G><P><V><Q><S><N><I><V><E><N><S><L><A><G><E><V><T><K><T><I><G><N><N><G><D><Q><S><H><K><M><T><T><S><R><C><V><R><L><M><L><I><S><M><A><N><D><L><K><E><V><W><I><S><E><Q><P><F><L><L><V><T><Y><L><W><Q><Y><M><P><T><W><A><W><W><I><T><N><K><M><G><K><K><R><I><E><N><F><K><S><G><V><D><A><D><S><S><Y><F><K><I><F><K><T><K><H><D> | NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics . Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function . Involved in the reduction of all-trans-retinal to all-trans-retinol . Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable . Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group . A dehydrogenase activity has not been detected so far . May play a role as tumor suppressor .<BOP> | Q9Y394 |
Q96D96 | HVCN1_HUMAN | Voltage sensor domain-only protein | Homo | <M><A><T><W><D><E><K><A><V><T><R><R><A><K><V><A><P><A><E><R><M><S><K><F><L><R><H><F><T><V><V><G><D><D><Y><H><A><W><N><I><N><Y><K><K><W><E><N><E><E><E><E><E><E><E><E><Q><P><P><P><T><P><V><S><G><E><E><G><R><A><A><A><P><D><V><A><P><A><P><G><P><A><P><R><A><P><L><D><F><R><G><M><L><R><K><L><F><S><S><H><R><F><Q><V><I><I><I><C><L><V><V><L><D><A><L><L><V><L><A><E><L><I><L><D><L><K><I><I><Q><P><D><K><N><N><Y><A><A><M><V><F><H><Y><M><S><I><T><I><L><V><F><F><M><M><E><I><I><F><K><L><F><V><F><R><L><E><F><F><H><H><K><F><E><I><L><D><A><V><V><V><V><V><S><F><I><L><D><I><V><L><L><F><Q><E><H><Q><F><E><A><L><G><L><L><I><L><L><R><L><W><R><V><A><R><I><I><N><G><I><I><I><S><V><K><T><R><S><E><R><Q><L><L><R><L><K><Q><M><N><V><Q><L><A><A><K><I><Q><H><L><E><F><S><C><S><E><K><E><Q><E><I><E><R><L><N><K><L><L><R><Q><H><G><L><L><G><E><V><N> | Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.<BOP> | Q96D96 |
Q92506 | DHB8_HUMAN | Testosterone 17-beta-dehydrogenase 8 | Homo | <M><A><S><Q><L><Q><N><R><L><R><S><A><L><A><L><V><T><G><A><G><S><G><I><G><R><A><V><S><V><R><L><A><G><E><G><A><T><V><A><A><C><D><L><D><R><A><A><A><Q><E><T><V><R><L><L><G><G><P><G><S><K><E><G><P><P><R><G><N><H><A><A><F><Q><A><D><V><S><E><A><R><A><A><R><C><L><L><E><Q><V><Q><A><C><F><S><R><P><P><S><V><V><V><S><C><A><G><I><T><Q><D><E><F><L><L><H><M><S><E><D><D><W><D><K><V><I><A><V><N><L><K><G><T><F><L><V><T><Q><A><A><A><Q><A><L><V><S><N><G><C><R><G><S><I><I><N><I><S><S><I><V><G><K><V><G><N><V><G><Q><T><N><Y><A><A><S><K><A><G><V><I><G><L><T><Q><T><A><A><R><E><L><G><R><H><G><I><R><C><N><S><V><L><P><G><F><I><A><T><P><M><T><Q><K><V><P><Q><K><V><V><D><K><I><T><E><M><I><P><M><G><H><L><G><D><P><E><D><V><A><D><V><V><A><F><L><A><S><E><D><S><G><Y><I><T><G><T><S><V><E><V><T><G><G><L><F><M> | Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex that acts as a scaffold protein required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference; this enzymatic activity is not needed for the KAR function . Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+) . Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown | Q92506 |
Q96CP7 | TLCD1_HUMAN | Calfacilitin | Homo | <M><P><R><L><L><H><P><A><L><P><L><L><L><G><A><T><L><T><F><R><A><L><R><R><A><L><C><R><L><P><L><P><V><H><V><R><A><D><P><L><R><T><W><R><W><H><N><L><L><V><S><F><A><H><S><I><V><S><G><I><W><A><L><L><C><V><W><Q><T><P><D><M><L><V><E><I><E><T><A><W><S><L><S><G><Y><L><L><V><C><F><S><A><G><Y><F><I><H><D><T><V><D><I><V><A><S><G><Q><T><R><A><S><W><E><Y><L><V><H><H><V><M><A><M><G><A><F><F><S><G><I><F><W><S><S><F><V><G><G><G><V><L><T><L><L><V><E><V><S><N><I><F><L><T><I><R><M><M><M><K><I><S><N><A><Q><D><H><L><L><Y><R><V><N><K><Y><V><N><L><V><M><Y><F><L><F><R><L><A><P><Q><A><Y><L><T><H><F><F><L><R><Y><V><N><Q><R><T><L><G><T><F><L><L><G><I><L><L><M><L><D><V><M><I><I><I><Y><F><S><R><L><L><R><S><D><F><C><P><E><H><V><P><K><K><Q><H><K><D><K><F><L><T><E> | Regulates the composition and fluidity of the plasma membrane . Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity . Does not appear to have any effect on LCPUFA synthesis .<BOP> | Q96CP7 |
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