Datasets:
yangzhang33
/
Prot2Text-Diff-HUMAN-func256-seq768

Dataset card Data Studio Files
xet
Community
1
accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
⌀
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
O00165
HAX1_HUMAN
HS1-binding protein 1
Homo
<M><S><L><F><D><L><F><R><G><F><F><G><F><P><G><P><R><S><H><R><D><P><F><F><G><G><M><T><R><D><E><D><D><D><E><E><E><E><E><E><G><G><S><W><G><R><G><N><P><R><F><H><S><P><Q><H><P><P><E><E><F><G><F><G><F><S><F><S><P><G><G><G><I><R><F><H><D><N><F><G><F><D><D><L><V><R><D><F><N><S><I><F><S><D><M><G><A><W><T><L><P><S><H><P><P><E><L><P><G><P><E><S><E><T><P><G><E><R><L><R><E><G><Q><T><L><R><D><S><M><L><K><Y><P><D><S><H><Q><P><R><I><F><G><G><V><L><E><S><D><A><R><S><E><S><P><Q><P><A><P><D><W><G><S><Q><R><P><F><H><R><F><D><D><V><W><P><M><D><P><H><P><R><T><R><E><D><N><D><L><D><S><Q><V><S><Q><E><G><L><G><P><V><L><Q><P><Q><P><K><S><Y><F><K><S><I><S><V><T><K><I><T><K><P><D><G><I><V><E><E><R><R><T><V><V><D><S><E><G><R><T><E><T><T><V><T><R><H><E><A><D><S><S><P><R><G><D><P><E><S><P><R><P><P><A><L><D><D><A><F><S><I><L><D><L><F><L><G><R><W><F><R><S><R>
Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex . Slows down the rate of inactivation of KCNC3 channels . Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.<BOP>
O00165
Q8NGJ6
O51A4_HUMAN
Olfactory receptor 51A4
Homo
<M><S><I><I><N><T><S><Y><V><E><I><T><T><F><F><L><V><G><M><P><G><L><E><Y><A><H><I><W><I><S><I><P><I><C><S><M><Y><L><I><A><I><L><G><N><G><T><I><L><F><I><I><K><T><E><P><S><L><H><E><P><M><Y><Y><F><L><S><M><L><A><M><S><D><L><G><L><S><L><S><S><L><P><T><V><L><S><I><F><L><F><N><A><P><E><I><S><S><N><A><C><F><A><Q><E><F><F><I><H><G><F><S><V><L><E><S><S><V><L><L><I><M><S><F><D><R><F><L><A><I><H><N><P><L><R><Y><T><S><I><L><T><T><V><R><V><A><Q><I><G><I><V><F><S><F><K><S><M><L><L><V><L><P><F><P><F><T><L><R><N><L><R><Y><C><K><K><N><Q><L><S><H><S><Y><C><L><H><Q><D><V><M><K><L><A><C><S><D><N><R><I><D><V><I><Y><G><F><F><G><A><L><C><L><M><V><D><F><I><L><I><A><V><S><Y><T><L><I><L><K><T><V><L><G><I><A><S><K><K><E><Q><L><K><A><L><N><T><C><V><S><H><I><C><A><V><I><I><F><Y><L><P><I><I><N><L><A><V><V><H><R><F><A><R><H><V><S><P><L><I><N><V><L><M><A><N><V><L><L><L><V><P><P><L><T><N><P><I><V><Y><C><V><K><T><K><Q><I><R><V><R><V><V><A><K><L><C><Q><R><K><I>
Odorant receptor.<BOP>
Q8NGJ6
P01344
IGF2_HUMAN
Preptin
Homo
<M><G><I><P><M><G><K><S><M><L><V><L><L><T><F><L><A><F><A><S><C><C><I><A><A><Y><R><P><S><E><T><L><C><G><G><E><L><V><D><T><L><Q><F><V><C><G><D><R><G><F><Y><F><S><R><P><A><S><R><V><S><R><R><S><R><G><I><V><E><E><C><C><F><R><S><C><D><L><A><L><L><E><T><Y><C><A><T><P><A><K><S><E><R><D><V><S><T><P><P><T><V><L><P><D><N><F><P><R><Y><P><V><G><K><F><F><Q><Y><D><T><W><K><Q><S><T><Q><R><L><R><R><G><L><P><A><L><L><R><A><R><R><G><H><V><L><A><K><E><L><E><A><F><R><E><A><K><R><H><R><P><L><I><A><L><P><T><Q><D><P><A><H><G><G><A><P><P><E><M><A><S><N><R><K>
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.<BOP>
P01344
Q9NQG6
MID51_HUMAN
Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like
Homo
<M><A><G><A><G><E><R><K><G><K><K><D><D><N><G><I><G><T><A><I><D><F><V><L><S><N><A><R><L><V><L><G><V><G><G><A><A><M><L><G><I><A><T><L><A><V><K><R><M><Y><D><R><A><I><S><A><P><T><S><P><T><R><L><S><H><S><G><K><R><S><W><E><E><P><N><W><M><G><S><P><R><L><L><N><R><D><M><K><T><G><L><S><R><S><L><Q><T><L><P><T><D><S><S><T><F><D><T><D><T><F><C><P><P><R><P><K><P><V><A><R><K><G><Q><V><D><L><K><K><S><R><L><R><M><S><L><Q><E><K><L><L><T><Y><Y><R><N><R><A><A><I><P><A><G><E><Q><A><R><A><K><Q><A><A><V><D><I><C><A><E><L><R><S><F><L><R><A><K><L><P><D><M><P><L><R><D><M><Y><L><S><G><S><L><Y><D><D><L><Q><V><V><T><A><D><H><I><Q><L><I><V><P><L><V><L><E><Q><N><L><W><S><C><I><P><G><E><D><T><I><M><N><V><P><G><F><F><L><V><R><R><E><N><P><E><Y><F><P><R><G><S><S><Y><W><D><R><C><V><V><G><G><Y><L><S><P><K><T><V><A><D><T><F><E><K><V><V><A><G><S><I><N><W><P><A><I><G><S><L><L><D><Y><V><I><R><P><A><P><P><P><E><A><L><T><L><E><V><Q><Y><E><R><D><K><H><L><F><I><D><F><L><P><S><V><T><L><G><D><T><V><L><V><A><K><P><H><R><L><A><Q><Y><D><N><L><W><R><L><S><L><R><P><A><E><T><A><R><L><R><A><L><D><Q><A><D><S><G><C><R><S><L><C><L><K><I><L><K><A><I><C><K><S><T><P><A><L><G><H><L><T><A><S><Q><L><T><N><V><I><L><H><L><A><Q><E><E><A><D><W><S><P><D><M><L><A><D><R><F><L><Q><A><L><R><G><L><I><S><Y><L><E><A><G><V><L><P><S><A><L><N><P><K><V><N><L><F><A><E><L><T><P><E><E><I><D><E><L><G><Y><T><L><Y><C><S><L><S><E><P><E><V><L><L><Q><T>
Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.<BOP>
Q9NQG6
O43929
ORC4_HUMAN
Origin recognition complex subunit 4
Homo
<M><S><S><R><K><S><K><S><N><S><L><I><H><T><E><C><L><S><Q><V><Q><R><I><L><R><E><R><F><C><R><Q><S><P><H><S><N><L><F><G><V><Q><V><Q><Y><K><H><L><S><E><L><L><K><R><T><A><L><H><G><E><S><N><S><V><L><I><I><G><P><R><G><S><G><K><T><M><L><I><N><H><A><L><K><E><L><M><E><I><E><E><V><S><E><N><V><L><Q><V><H><L><N><G><L><L><Q><I><N><D><K><I><A><L><K><E><I><T><R><Q><L><N><L><E><N><V><V><G><D><K><V><F><G><S><F><A><E><N><L><S><F><L><L><E><A><L><K><K><G><D><R><T><S><S><C><P><V><I><F><I><L><D><E><F><D><L><F><A><H><H><K><N><Q><T><L><L><Y><N><L><F><D><I><S><Q><S><A><Q><T><P><I><A><V><I><G><L><T><C><R><L><D><I><L><E><L><L><E><K><R><V><K><S><R><F><S><H><R><Q><I><H><L><M><N><S><F><G><F><P><Q><Y><V><K><I><F><K><E><Q><L><S><L><P><A><E><F><P><D><K><V><F><A><E><K><W><N><E><N><V><Q><Y><L><S><E><D><R><S><V><Q><E><V><L><Q><K><H><F><N><I><S><K><N><L><R><S><L><H><M><L><L><M><L><A><L><N><R><V><T><A><S><H><P><F><M><T><A><V><D><L><M><E><A><S><Q><L><C><S><M><D><S><K><A><N><I><V><H><G><L><S><V><L><E><I><C><L><I><I><A><M><K><H><L><N><D><I><Y><E><E><E><P><F><N><F><Q><M><V><Y><N><E><F><Q><K><F><V><Q><R><K><A><H><S><V><Y><N><F><E><K><P><V><V><M><K><A><F><E><H><L><Q><Q><L><E><L><I><K><P><M><E><R><T><S><G><N><S><Q><R><E><Y><Q><L><M><K><L><L><L><D><N><T><Q><I><M><N><A><L><Q><K><Y><P><N><C><P><T><D><V><R><Q><W><A><T><S><S><L><S><W><L>
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.<BOP>
O43929
P56880
CLD20_HUMAN
Claudin-20
Homo
<M><A><S><A><G><L><Q><L><L><A><F><I><L><A><L><S><G><V><S><G><V><L><T><A><T><L><L><P><N><W><K><V><N><V><D><V><D><S><N><I><I><T><A><I><V><Q><L><H><G><L><W><M><D><C><T><W><Y><S><T><G><M><F><S><C><A><L><K><H><S><I><L><S><L><P><I><H><V><Q><A><A><R><A><T><M><V><L><A><C><V><L><S><A><L><G><I><C><T><S><T><V><G><M><K><C><T><R><L><G><G><D><R><E><T><K><S><H><A><S><F><A><G><G><V><C><F><M><S><A><G><I><S><S><L><I><S><T><V><W><Y><T><K><E><I><I><A><N><F><L><D><L><T><V><P><E><S><N><K><H><E><P><G><G><A><I><Y><I><G><F><I><S><A><M><L><L><F><I><S><G><M><I><F><C><T><S><C><I><K><R><N><P><E><A><R><L><D><P><P><T><Q><Q><P><I><S><N><T><Q><L><E><N><N><S><T><H><N><L><K><D><Y><V>
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.<BOP>
P56880
P20800
EDN2_HUMAN
Preproendothelin-2
Homo
<M><V><S><V><P><T><T><W><C><S><V><A><L><A><L><L><V><A><L><H><E><G><K><G><Q><A><A><A><T><L><E><Q><P><A><S><S><S><H><A><Q><G><T><H><L><R><L><R><R><C><S><C><S><S><W><L><D><K><E><C><V><Y><F><C><H><L><D><I><I><W><V><N><T><P><E><Q><T><A><P><Y><G><L><G><N><P><P><R><R><R><R><R><S><L><P><R><R><C><Q><C><S><S><A><R><D><P><A><C><A><T><F><C><L><R><R><P><W><T><E><A><G><A><V><P><S><R><K><S><P><A><D><V><F><Q><T><G><K><T><G><A><T><T><G><E><L><L><Q><R><L><R><D><I><S><T><V><K><S><L><F><A><K><R><Q><Q><E><A><M><R><E><P><R><S><T><H><S><R><W><R><K><R>
Endothelins are endothelium-derived vasoconstrictor peptides.<BOP>
P20800
Q15834
CC85B_HUMAN
Hepatitis delta antigen-interacting protein A
Homo
<M><E><A><E><A><G><G><L><E><E><L><T><D><E><E><M><A><A><L><G><K><E><E><L><V><R><R><L><R><R><E><E><A><A><R><L><A><A><L><V><Q><R><G><R><L><M><Q><E><V><N><R><Q><L><Q><G><H><L><G><E><I><R><E><L><K><Q><L><N><R><R><L><Q><A><E><N><R><E><L><R><D><L><C><C><F><L><D><S><E><R><Q><R><G><R><R><A><A><R><Q><W><Q><L><F><G><T><Q><A><S><R><A><V><R><E><D><L><G><G><C><W><Q><K><L><A><E><L><E><G><R><Q><E><E><L><L><R><E><N><L><A><L><K><E><L><C><L><A><L><G><E><E><W><G><P><R><G><G><P><S><G><A><G><G><S><G><A><G><P><A><P><E><L><A><L><P><P><C><G><P><R><D><L><G><D><G><S><S><S><T><G><S><V><G><S><P><D><Q><L><P><L><A><C><S><P><D><D>
(Microbial infection) Plays a role in hepatitis delta virus (HDV) genomic replication.<BOP>
Q15834
Q9HA82
CERS4_HUMAN
Sphingosine N-acyltransferase CERS4
Homo
<M><L><S><S><F><N><E><W><F><W><Q><D><R><F><W><L><P><P><N><V><T><W><T><E><L><E><D><R><D><G><R><V><Y><P><H><P><Q><D><L><L><A><A><L><P><L><A><L><V><L><L><A><M><R><L><A><F><E><R><F><I><G><L><P><L><S><R><W><L><G><V><R><D><Q><T><R><R><Q><V><K><P><N><A><T><L><E><K><H><F><L><T><E><G><H><R><P><K><E><P><Q><L><S><L><L><A><A><Q><C><G><L><T><L><Q><Q><T><Q><R><W><F><R><R><R><R><N><Q><D><R><P><Q><L><T><K><K><F><C><E><A><S><W><R><F><L><F><Y><L><S><S><F><V><G><G><L><S><V><L><Y><H><E><S><W><L><W><A><P><V><M><C><W><D><R><Y><P><N><Q><T><L><K><P><S><L><Y><W><W><Y><L><L><E><L><G><F><Y><L><S><L><L><I><R><L><P><F><D><V><K><R><K><D><F><K><E><Q><V><I><H><H><F><V><A><V><I><L><M><T><F><S><Y><S><A><N><L><L><R><I><G><S><L><V><L><L><L><H><D><S><S><D><Y><L><L><E><A><C><K><M><V><N><Y><M><Q><Y><Q><Q><V><C><D><A><L><F><L><I><F><S><F><V><F><F><Y><T><R><L><V><L><F><P><T><Q><I><L><Y><T><T><Y><Y><E><S><I><S><N><R><G><P><F><F><G><Y><Y><F><F><N><G><L><L><M><L><L><Q><L><L><H><V><F><W><S><C><L><I><L><R><M><L><Y><S><F><M><K><K><G><Q><M><E><K><D><I><R><S><D><V><E><E><S><D><S><S><E><E><A><A><A><A><Q><E><P><L><Q><L><K><N><G><A><A><G><G><P><R><P><A><P><T><D><G><P><R><S><R><V><A><G><R><L><T><N><R><H><T><T><A><T>
Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor.<BOP>
Q9HA82
Q9NPD5
SO1B3_HUMAN
Solute carrier family 21 member 8
Homo
<M><D><Q><H><Q><H><L><N><K><T><A><E><S><A><S><S><E><K><K><K><T><R><R><C><N><G><F><K><M><F><L><A><A><L><S><F><S><Y><I><A><K><A><L><G><G><I><I><M><K><I><S><I><T><Q><I><E><R><R><F><D><I><S><S><S><L><A><G><L><I><D><G><S><F><E><I><G><N><L><L><V><I><V><F><V><S><Y><F><G><S><K><L><H><R><P><K><L><I><G><I><G><C><L><L><M><G><T><G><S><I><L><T><S><L><P><H><F><F><M><G><Y><Y><R><Y><S><K><E><T><H><I><N><P><S><E><N><S><T><S><S><L><S><T><C><L><I><N><Q><T><L><S><F><N><G><T><S><P><E><I><V><E><K><D><C><V><K><E><S><G><S><H><M><W><I><Y><V><F><M><G><N><M><L><R><G><I><G><E><T><P><I><V><P><L><G><I><S><Y><I><D><D><F><A><K><E><G><H><S><S><L><Y><L><G><S><L><N><A><I><G><M><I><G><P><V><I><G><F><A><L><G><S><L><F><A><K><M><Y><V><D><I><G><Y><V><D><L><S><T><I><R><I><T><P><K><D><S><R><W><V><G><A><W><W><L><G><F><L><V><S><G><L><F><S><I><I><S><S><I><P><F><F><F><L><P><K><N><P><N><K><P><Q><K><E><R><K><I><S><L><S><L><H><V><L><K><T><N><D><D><R><N><Q><T><A><N><L><T><N><Q><G><K><N><V><T><K><N><V><T><G><F><F><Q><S><L><K><S><I><L><T><N><P><L><Y><V><I><F><L><L><L><T><L><L><Q><V><S><S><F><I><G><S><F><T><Y><V><F><K><Y><M><E><Q><Q><Y><G><Q><S><A><S><H><A><N><F><L><L><G><I><I><T><I><P><T><V><A><T><G><M><F><L><G><G><F><I><I><K><K><F><K><L><S><L><V><G><I><A><K><F><S><F><L><T><S><M><I><S><F><L><F><Q><L><L><Y><F><P><L><I><C><E><S><K><S><V><A><G><L><T><L><T><Y><D><G><N><N><S><V><A><S><H><V><D><V><P><L><S><Y><C><N><S><E><C><N><C><D><E><S><Q><W><E><P><V><C><G><N><N><G><I><T><Y><L><S><P><C><L><A><G><C><K><S><S><S><G><I><K><K><H><T><V><F><Y><N><C><S><C><V><E><V><T><G><L><Q><N><R><N><Y><S><A><H><L><G><E><C><P><R><D><N><T><C><T><R><K><F><F><I><Y><V><A><I><Q><V><I><N><S><L><F><S><A><T><G><G><T><T><F><I><L><L><T><V><K><I><V><Q><P><E><L><K><A><L><A><M><G><F><Q><S><M><V><I><R><T><L><G><G><I><L><A><P><I><Y><F><G><A><L><I><D><K><T><C><M><K><W><S><T><N><S><C><G><A><Q><G><A><C><R><I><Y><N><S><V><F><F><G><R><V><Y><L><G><L><S><I><A><L><R><F><P><A><L><V><L><Y><I><V><F><I><F><A><M><K><K><K><F><Q><G><K><D><T><K><A><S><D><N><E><R><K><V><M><D><E><A><N><L><E><F><L><N><N><G><E><H><F><V><P><S><A><G><T><D><S><K><T><C><N><L><D><M><Q><D><N><A><A><A><N>
Mediates the Na(+)-independent uptake of organic anions . Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate), as well as eicosanoid leukotriene C4 . Involved in the clearance of bile acids and organic anions from the liver . Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop . Can transport HMG-CoA reductase inhibitors (also known as statins) such as pitavastatin, a clinically important class of hypolipidemic drugs . May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel . May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in
Q9NPD5
Q96IV0
NGLY1_HUMAN
Peptide:N-glycanase
Homo
<M><A><A><A><A><L><G><S><S><S><G><S><A><S><P><A><V><A><E><L><C><Q><N><T><P><E><T><F><L><E><A><S><K><L><L><L><T><Y><A><D><N><I><L><R><N><P><N><D><E><K><Y><R><S><I><R><I><G><N><T><A><F><S><T><R><L><L><P><V><R><G><A><V><E><C><L><F><E><M><G><F><E><E><G><E><T><H><L><I><F><P><K><K><A><S><V><E><Q><L><Q><K><I><R><D><L><I><A><I><E><R><S><S><R><L><D><G><S><N><K><S><H><K><V><K><S><S><Q><Q><P><A><A><S><T><Q><L><P><T><T><P><S><S><N><P><S><G><L><N><Q><H><T><R><N><R><Q><G><Q><S><S><D><P><P><S><A><S><T><V><A><A><D><S><A><I><L><E><V><L><Q><S><N><I><Q><H><V><L><V><Y><E><N><P><A><L><Q><E><K><A><L><A><C><I><P><V><Q><E><L><K><R><K><S><Q><E><K><L><S><R><A><R><K><L><D><K><G><I><N><I><S><D><E><D><F><L><L><L><E><L><L><H><W><F><K><E><E><F><F><H><W><V><N><N><V><L><C><S><K><C><G><G><Q><T><R><S><R><D><R><S><L><L><P><S><D><D><E><L><K><W><G><A><K><E><V><E><D><H><Y><C><D><A><C><Q><F><S><N><R><F><P><R><Y><N><N><P><E><K><L><L><E><T><R><C><G><R><C><G><E><W><A><N><C><F><T><L><C><C><R><A><V><G><F><E><A><R><Y><V><W><D><Y><T><D><H><V><W><T><E><V><Y><S><P><S><Q><Q><R><W><L><H><C><D><A><C><E><D><V><C><D><K><P><L><L><Y><E><I><G><W><G><K><K><L><S><Y><V><I><A><F><S><K><D><E><V><V><D><V><T><W><R><Y><S><C><K><H><E><E><V><I><A><R><R><T><K><V><K><E><A><L><L><R><D><T><I><N><G><L><N><K><Q><R><Q><L><F><L><S><E><N><R><R><K><E><L><L><Q><R><I><I><V><E><L><V><E><F><I><S><P><K><T><P><K><P><G><E><L><G><G><R><I><S><G><S><V><A><W><R><V><A><R><G><E><M><G><L><Q><R><K><E><T><L><F><I><P><C><E><N><E><K><I><S><K><Q><L><H><L><C><Y><N><I><V><K><D><R><Y><V><R><V><S><N><N><N><Q><T><I><S><G><W><E><N><G><V><W><K><M><E><S><I><F><R><K><V><E><T><D><W><H><M><V><Y><L><A><R><K><E><G><S><S><F><A><Y><I><S><W><K><F><E><C><G><S><V><G><L><K><V><D><S><I><S><I><R><T><S><S><Q><T><F><Q><T><G><T><V><E><W><K><L><R><S><D><T><A><Q><V><E><L><T><G><D><N><S><L><H><S><Y><A><D><F><S><G><A><T><E><V><I><L><E><A><E><L><S><R><G><D><G><D><V><A><W><Q><H><T><Q><L><F><R><Q><S><L><N><D><H><E><E><N><C><L><E><I><I><I><K><F><S><D><L>
Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.<BOP>
Q96IV0
Q9NSJ1
Z355P_HUMAN
Zinc finger protein ZnFP01
Homo
<M><R><D><E><V><A><E><K><E><K><A><D><I><N><V><T><L><V><F><Q><G><Y><E><N><T><P><I><M><V><C><V><D><G><I><V><F><S><K><P><D><L><V><T><C><L><E><Q><R><K><K><P><W><S><M><K><H><P><G><L><T><Q><H><N><I><V><H><T><G><D><K><P><Y><K><C><K><D><C><G><K><I><F><K><W><S><S><N><L><T><I><H><Q><R><I><H><S><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><Q><S><S><K><L><N><E><H><M><R><A><H><T><G><E><K><F><Y><K><C><E><E><C><G><K><A><F><K><H><P><S><G><L><T><L><H><K><R><I><H><T><G><E><N><P><Y><K><F><E><E><C><D><K><A><F><Y><W><V><L><S><F><T><K><H><M><I><I><H><R><G><E><K><P><Y><K><Y><Q><E><C><G><K><A><F><K><W><S><S><N><L><T><I><H><K><R><I><H><T><G><E><K><P><C><K><C><E><E><C><G><K><A><C><K><Q><S><L><G><L><T><I><Q><K><R><I><H><T><E><E><K><P><Y><K><C><E><E><C><G><S><S><N><L><T><I><Y><K><K><I><H><A><G><E><K><P><Y><N><C><E><K><C><G><K><A><F><Y><C><S><S><N><L><I><Q><N><N><I><V><H><A><E><E><K><H><Y><K><C><Q><E><C><G><K><A><F><K><K><S><L><D><L><N><V><H><K><I><I><H><S><G><E><K><P><Y><R><Y><E><E><C><G><K><I><T><H><S><G><E><E><S><Y><K><C><E><E><C><G><K><G><F><Y><C><S><S><S><L><T><K><H><M><I><V><H><T><E><E><K><L><Y><K><C><E><E><C><G><K><A><F><K><W><S><S><E><L><T><I><H><Q><R><I><R><T><E><E><K><P><Y><K><C><E><E><C><V><R><V><F><K><H><S><S><K><L><N><E><H><K><R><N><H><T><G><E><K><P><Y><K><C><E><A><C><G><K><A><F>
May be involved in transcriptional regulation.<BOP>
Q9NSJ1
A0A0G2JS06
LV539_HUMAN
Immunoglobulin lambda variable 5-39
Homo
<M><A><W><T><P><L><L><L><L><L><L><S><H><C><T><G><S><L><S><Q><P><V><L><T><Q><P><T><S><L><S><A><S><P><G><A><S><A><R><F><T><C><T><L><R><S><G><I><N><V><G><T><Y><R><I><Y><W><Y><Q><Q><K><P><G><S><L><P><R><Y><L><L><R><Y><K><S><D><S><D><K><Q><Q><G><S><G><V><P><S><R><F><S><G><S><K><D><A><S><T><N><A><G><L><L><L><I><S><G><L><Q><S><E><D><E><A><D><Y><Y><C><A><I><W><Y><S><S><T><S>
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0A0G2JS06
Q9NWS0
PIHD1_HUMAN
Nucleolar protein 17 homolog
Homo
<M><A><N><P><K><L><L><G><M><G><L><S><E><A><E><A><I><G><A><D><S><A><R><F><E><E><L><L><L><Q><A><S><K><E><L><Q><Q><A><Q><T><T><R><P><E><S><T><Q><I><Q><P><Q><P><G><F><C><I><K><T><N><S><S><E><G><K><V><F><I><N><I><C><H><S><P><S><I><P><P><P><A><D><V><T><E><E><E><L><L><Q><M><L><E><E><D><Q><A><G><F><R><I><P><M><S><L><G><E><P><H><A><E><L><D><A><K><G><Q><G><C><T><A><Y><D><V><A><V><N><S><D><F><Y><R><R><M><Q><N><S><D><F><L><R><E><L><V><I><T><I><A><R><E><G><L><E><D><K><Y><N><L><Q><L><N><P><E><W><R><M><M><K><N><R><P><F><M><G><S><I><S><Q><Q><N><I><R><S><E><Q><R><P><R><I><Q><E><L><G><D><L><Y><T><P><A><P><G><R><A><E><S><G><P><E><K><P><H><L><N><L><W><L><E><A><P><D><L><L><L><A><E><V><D><L><P><K><L><D><G><A><L><G><L><S><L><E><I><G><E><N><R><L><V><M><G><G><P><Q><Q><L><Y><H><L><D><A><Y><I><P><L><Q><I><N><S><H><E><S><K><A><A><F><H><R><K><R><K><Q><L><M><V><A><M><P><L><L><P><V><P><S>
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles . Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription . Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 . Positively regulates the assembly and activity of the mTORC1 complex .<BOP>
Q9NWS0
O95274
LYPD3_HUMAN
Matrigel-induced gene C4 protein
Homo
<M><D><P><A><R><K><A><G><A><Q><A><M><I><W><T><A><G><W><L><L><L><L><L><L><R><G><G><A><Q><A><L><E><C><Y><S><C><V><Q><K><A><D><D><G><C><S><P><N><K><M><K><T><V><K><C><A><P><G><V><D><V><C><T><E><A><V><G><A><V><E><T><I><H><G><Q><F><S><L><A><V><R><G><C><G><S><G><L><P><G><K><N><D><R><G><L><D><L><H><G><L><L><A><F><I><Q><L><Q><Q><C><A><Q><D><R><C><N><A><K><L><N><L><T><S><R><A><L><D><P><A><G><N><E><S><A><Y><P><P><N><G><V><E><C><Y><S><C><V><G><L><S><R><E><A><C><Q><G><T><S><P><P><V><V><S><C><Y><N><A><S><D><H><V><Y><K><G><C><F><D><G><N><V><T><L><T><A><A><N><V><T><V><S><L><P><V><R><G><C><V><Q><D><E><F><C><T><R><D><G><V><T><G><P><G><F><T><L><S><G><S><C><C><Q><G><S><R><C><N><S><D><L><R><N><K><T><Y><F><S><P><R><I><P><P><L><V><R><L><P><P><P><E><P><T><T><V><A><S><T><T><S><V><T><T><S><T><S><A><P><V><R><P><T><S><T><T><K><P><M><P><A><P><T><S><Q><T><P><R><Q><G><V><E><H><E><A><S><R><D><E><E><P><R><L><T><G><G><A><A><G><H><Q><D><R><S><N><S><G><Q><Y><P><A><K><G><G><P><Q><Q><P><H><N><K><G><C><V><A><P><T><A><G><L><A><A><L><L><L><A><V><A><A><G><V><L><L>
Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.<BOP>
O95274
Q9Y5W5
WIF1_HUMAN
Wnt inhibitory factor 1
Homo
<M><A><R><R><S><A><F><P><A><A><A><L><W><L><W><S><I><L><L><C><L><L><A><L><R><A><E><A><G><P><P><Q><E><E><S><L><Y><L><W><I><D><A><H><Q><A><R><V><L><I><G><F><E><E><D><I><L><I><V><S><E><G><K><M><A><P><F><T><H><D><F><R><K><A><Q><Q><R><M><P><A><I><P><V><N><I><H><S><M><N><F><T><W><Q><A><A><G><Q><A><E><Y><F><Y><E><F><L><S><L><R><S><L><D><K><G><I><M><A><D><P><T><V><N><V><P><L><L><G><T><V><P><H><K><A><S><V><V><Q><V><G><F><P><C><L><G><K><Q><D><G><V><A><A><F><E><V><D><V><I><V><M><N><S><E><G><N><T><I><L><Q><T><P><Q><N><A><I><F><F><K><T><C><Q><Q><A><E><C><P><G><G><C><R><N><G><G><F><C><N><E><R><R><I><C><E><C><P><D><G><F><H><G><P><H><C><E><K><A><L><C><T><P><R><C><M><N><G><G><L><C><V><T><P><G><F><C><I><C><P><P><G><F><Y><G><V><N><C><D><K><A><N><C><S><T><T><C><F><N><G><G><T><C><F><Y><P><G><K><C><I><C><P><P><G><L><E><G><E><Q><C><E><I><S><K><C><P><Q><P><C><R><N><G><G><K><C><I><G><K><S><K><C><K><C><S><K><G><Y><Q><G><D><L><C><S><K><P><V><C><E><P><G><C><G><A><H><G><T><C><H><E><P><N><K><C><Q><C><Q><E><G><W><H><G><R><H><C><N><K><R><Y><E><A><S><L><I><H><A><L><R><P><A><G><A><Q><L><R><Q><H><T><P><S><L><K><K><A><E><E><R><R><D><P><P><E><S><N><Y><I><W>
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.<BOP>
Q9Y5W5
Q96G75
RMD5B_HUMAN
Protein RMD5 homolog B
Homo
<M><E><Q><C><A><C><V><E><R><E><L><D><K><V><L><Q><K><F><L><T><Y><G><Q><H><C><E><R><S><L><E><E><L><L><H><Y><V><G><Q><L><R><A><E><L><A><S><A><A><L><Q><G><T><P><L><S><A><T><L><S><L><V><M><S><Q><C><C><R><K><I><K><D><T><V><Q><K><L><A><S><D><H><K><D><I><H><S><S><V><S><R><V><G><K><A><I><D><R><N><F><D><S><E><I><C><G><V><V><S><D><A><V><W><D><A><R><E><Q><Q><Q><Q><I><L><Q><M><A><I><V><E><H><L><Y><Q><Q><G><M><L><S><V><A><E><E><L><C><Q><E><S><T><L><N><V><D><L><D><F><K><Q><P><F><L><E><L><N><R><I><L><E><A><L><H><E><Q><D><L><G><P><A><L><E><W><A><V><S><H><R><Q><R><L><L><E><L><N><S><S><L><E><F><K><L><H><R><L><H><F><I><R><L><L><A><G><G><P><A><K><Q><L><E><A><L><S><Y><A><R><H><F><Q><P><F><A><R><L><H><Q><R><E><I><Q><V><M><M><G><S><L><V><Y><L><R><L><G><L><E><K><S><P><Y><C><H><L><L><D><S><S><H><W><A><E><I><C><E><T><F><T><R><D><A><C><S><L><L><G><L><S><V><E><S><P><L><S><V><S><F><A><S><G><C><V><A><L><P><V><L><M><N><I><K><A><V><I><E><Q><R><Q><C><T><G><V><W><N><H><K><D><E><L><P><I><E><I><E><L><G><M><K><C><W><Y><H><S><V><F><A><C><P><I><L><R><Q><Q><T><S><D><S><N><P><P><I><K><L><I><C><G><H><V><I><S><R><D><A><L><N><K><L><I><N><G><G><K><L><K><C><P><Y><C><P><M><E><Q><N><P><A><D><G><K><R><I><I><F>
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex . Catalytic activity of the complex is required for normal cell proliferation . The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 .<BOP>
Q96G75
Q9BUE0
MED18_HUMAN
p28b
Homo
<M><E><A><P><P><V><T><M><M><P><V><T><G><G><T><I><N><M><M><E><Y><L><L><Q><G><S><V><L><D><H><S><L><E><S><L><I><H><R><L><R><G><L><C><D><N><M><E><P><E><T><F><L><D><H><E><M><V><F><L><L><K><G><Q><Q><A><S><P><F><V><L><R><A><R><R><S><M><D><R><A><G><A><P><W><H><L><R><Y><L><G><Q><P><E><M><G><D><K><N><R><H><A><L><V><R><N><C><V><D><I><A><T><S><E><N><L><T><D><F><L><M><E><M><G><F><R><M><D><H><E><F><V><A><K><G><H><L><F><R><K><G><I><M><K><I><M><V><Y><K><I><F><R><I><L><V><P><G><N><T><D><S><T><E><A><L><S><L><S><Y><L><V><E><L><S><V><V><A><P><A><G><Q><D><M><V><S><D><D><M><K><N><F><A><E><Q><L><K><P><L><V><H><L><E><K><I><D><P><K><R><L><M>
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<BOP>
Q9BUE0
Q9NW64
RBM22_HUMAN
Zinc finger CCCH domain-containing protein 16
Homo
<M><A><T><S><L><G><S><N><T><Y><N><R><Q><N><W><E><D><A><D><F><P><I><L><C><Q><T><C><L><G><E><N><P><Y><I><R><M><T><K><E><K><Y><G><K><E><C><K><I><C><A><R><P><F><T><V><F><R><W><C><P><G><V><R><M><R><F><K><K><T><E><V><C><Q><T><C><S><K><L><K><N><V><C><Q><T><C><L><L><D><L><E><Y><G><L><P><I><Q><V><R><D><A><G><L><S><F><K><D><D><M><P><K><S><D><V><N><K><E><Y><Y><T><Q><N><M><E><R><E><I><S><N><S><D><G><T><R><P><V><G><M><L><G><K><A><T><S><T><S><D><M><L><L><K><L><A><R><T><T><P><Y><Y><K><R><N><R><P><H><I><C><S><F><W><V><K><G><E><C><K><R><G><E><E><C><P><Y><R><H><E><K><P><T><D><P><D><D><P><L><A><D><Q><N><I><K><D><R><Y><Y><G><I><N><D><P><V><A><D><K><L><L><K><R><A><S><T><M><P><R><L><D><P><P><E><D><K><T><I><T><T><L><Y><V><G><G><L><G><D><T><I><T><E><T><D><L><R><N><H><F><Y><Q><F><G><E><I><R><T><I><T><V><V><Q><R><Q><Q><C><A><F><I><Q><F><A><T><R><Q><A><A><E><V><A><A><E><K><S><F><N><K><L><I><V><N><G><R><R><L><N><V><K><W><G><R><S><Q><A><A><R><G><K><E><K><E><K><D><G><T><T><D><S><G><I><K><L><E><P><V><P><G><L><P><G><A><L><P><P><P><P><A><A><E><E><E><A><S><A><N><Y><F><N><L><P><P><S><G><P><P><A><V><V><N><I><A><L><P><P><P><P><G><I><A><P><P><P><P><P><G><F><G><P><H><M><F><H><P><M><G><P><P><P><P><F><M><R><A><P><G><P><I><H><Y><P><S><Q><D><P><Q><R><M><G><A><H><A><G><K><H><S><S><P>
Required for pre-mRNA splicing as component of the activated spliceosome . Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.<BOP>
Q9NW64
Q12849
GRSF1_HUMAN
G-rich sequence factor 1
Homo
<M><A><G><T><R><W><V><L><G><A><L><L><R><G><C><G><C><N><C><S><S><C><R><R><T><G><A><A><C><L><P><F><Y><S><A><A><G><S><I><P><S><G><V><S><G><R><R><R><L><L><L><L><L><G><A><A><A><A><A><A><S><Q><T><R><G><L><Q><T><G><P><V><P><P><G><R><L><A><G><P><P><A><V><A><T><S><A><A><A><A><A><A><A><S><Y><S><A><L><R><A><S><L><L><P><Q><S><L><A><A><A><A><A><V><P><T><R><S><Y><S><Q><E><S><K><T><T><Y><L><E><D><L><P><P><P><P><E><Y><E><L><A><P><S><K><L><E><E><E><V><D><D><V><F><L><I><R><A><Q><G><L><P><W><S><C><T><M><E><D><V><L><N><F><F><S><D><C><R><I><R><N><G><E><N><G><I><H><F><L><L><N><R><D><G><K><R><R><G><D><A><L><I><E><M><E><S><E><Q><D><V><Q><K><A><L><E><K><H><R><M><Y><M><G><Q><R><Y><V><E><V><Y><E><I><N><N><E><D><V><D><A><L><M><K><S><L><Q><V><K><S><S><P><V><V><N><D><G><V><V><R><L><R><G><L><P><Y><S><C><N><E><K><D><I><V><D><F><F><A><G><L><N><I><V><D><I><T><F><V><M><D><Y><R><G><R><R><K><T><G><E><A><Y><V><Q><F><E><E><P><E><M><A><N><Q><A><L><L><K><H><R><E><E><I><G><N><R><Y><I><E><I><F><P><S><R><R><N><E><V><R><T><H><V><G><S><Y><K><G><K><K><I><A><S><F><P><T><A><K><Y><I><T><E><P><E><M><V><F><E><E><H><E><V><N><E><D><I><Q><P><M><T><A><F><E><S><E><K><E><I><E><L><P><K><E><V><P><E><K><L><P><E><A><A><D><F><G><T><T><S><S><L><H><F><V><H><M><R><G><L><P><F><Q><A><N><A><Q><D><I><I><N><F><F><A><P><L><K><P><V><R><I><T><M><E><Y><S><S><S><G><K><A><T><G><E><A><D><V><H><F><E><T><H><E><D><A><V><A><A><M><L><K><D><R><S><H><V><H><H><R><Y><I><E><L><F><L><N><S><C><P><K><G><K>
Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences . Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules . Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome . G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA .<BOP>
Q12849
Q92504
S39A7_HUMAN
Zrt-, Irt-like protein 7
Homo
<M><A><R><G><L><G><A><P><H><W><V><A><V><G><L><L><T><W><A><T><L><G><L><L><V><A><G><L><G><G><H><D><D><L><H><D><D><L><Q><E><D><F><H><G><H><S><H><R><H><S><H><E><D><F><H><H><G><H><S><H><A><H><G><H><G><H><T><H><E><S><I><W><H><G><H><T><H><D><H><D><H><G><H><S><H><E><D><L><H><H><G><H><S><H><G><Y><S><H><E><S><L><Y><H><R><G><H><G><H><D><H><E><H><S><H><G><G><Y><G><E><S><G><A><P><G><I><K><Q><D><L><D><A><V><T><L><W><A><Y><A><L><G><A><T><V><L><I><S><A><A><P><F><F><V><L><F><L><I><P><V><E><S><N><S><P><R><H><R><S><L><L><Q><I><L><L><S><F><A><S><G><G><L><L><G><D><A><F><L><H><L><I><P><H><A><L><E><P><H><S><H><H><T><L><E><Q><P><G><H><G><H><S><H><S><G><Q><G><P><I><L><S><V><G><L><W><V><L><S><G><I><V><A><F><L><V><V><E><K><F><V><R><H><V><K><G><G><H><G><H><S><H><G><H><G><H><A><H><S><H><T><R><G><S><H><G><H><G><R><Q><E><R><S><T><K><E><K><Q><S><S><E><E><E><E><K><E><T><R><G><V><Q><K><R><R><G><G><S><T><V><P><K><D><G><P><V><R><P><Q><N><A><E><E><E><K><R><G><L><D><L><R><V><S><G><Y><L><N><L><A><A><D><L><A><H><N><F><T><D><G><L><A><I><G><A><S><F><R><G><G><R><G><L><G><I><L><T><T><M><T><V><L><L><H><E><V><P><H><E><V><G><D><F><A><I><L><V><Q><S><G><C><S><K><K><Q><A><M><R><L><Q><L><L><T><A><V><G><A><L><A><G><T><A><C><A><L><L><T><E><G><G><A><V><G><S><E><I><A><G><G><A><G><P><G><W><V><L><P><F><T><A><G><G><F><I><Y><V><A><T><V><S><V><L><P><E><L><L><R><E><A><S><P><L><Q><S><L><L><E><V><L><G><L><L><G><G><V><I><M><M><V><L><I><A><H><L><E>
Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+). Has an essential role in B cell development and is required for proper B cell receptor signaling .<BOP>
Q92504
P55771
PAX9_HUMAN
Paired box protein Pax-9
Homo
<M><E><P><A><F><G><E><V><N><Q><L><G><G><V><F><V><N><G><R><P><L><P><N><A><I><R><L><R><I><V><E><L><A><Q><L><G><I><R><P><C><D><I><S><R><Q><L><R><V><S><H><G><C><V><S><K><I><L><A><R><Y><N><E><T><G><S><I><L><P><G><A><I><G><G><S><K><P><R><V><T><T><P><T><V><V><K><H><I><R><T><Y><K><Q><R><D><P><G><I><F><A><W><E><I><R><D><R><L><L><A><D><G><V><C><D><K><Y><N><V><P><S><V><S><S><I><S><R><I><L><R><N><K><I><G><N><L><A><Q><Q><G><H><Y><D><S><Y><K><Q><H><Q><P><T><P><Q><P><A><L><P><Y><N><H><I><Y><S><Y><P><S><P><I><T><A><A><A><A><K><V><P><T><P><P><G><V><P><A><I><P><G><S><V><A><M><P><R><T><W><P><S><S><H><S><V><T><D><I><L><G><I><R><S><I><T><D><Q><V><S><D><S><S><P><Y><H><S><P><K><V><E><E><W><S><S><L><G><R><N><N><F><P><A><A><A><P><H><A><V><N><G><L><E><K><G><A><L><E><Q><E><A><K><Y><G><Q><A><P><N><G><L><P><A><V><G><S><F><V><S><A><S><S><M><A><P><Y><P><T><P><A><Q><V><S><P><Y><M><T><Y><S><A><A><P><S><G><Y><V><A><G><H><G><W><Q><H><A><G><G><T><S><L><S><P><H><N><C><D><I><P><A><S><L><A><F><K><G><M><Q><A><A><R><E><G><S><H><S><V><T><A><S><A><L>
Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.<BOP>
P55771
Q9BSD7
NTPCR_HUMAN
Nucleoside triphosphate phosphohydrolase
Homo
<M><A><R><H><V><F><L><T><G><P><P><G><V><G><K><T><T><L><I><H><K><A><S><E><V><L><K><S><S><G><V><P><V><D><G><F><Y><T><E><E><V><R><Q><G><G><R><R><I><G><F><D><V><V><T><L><S><G><T><R><G><P><L><S><R><V><G><L><E><P><P><P><G><K><R><E><C><R><V><G><Q><Y><V><V><D><L><T><S><F><E><Q><L><A><L><P><V><L><R><N><A><D><C><S><S><G><P><G><Q><R><V><C><V><I><D><E><I><G><K><M><E><L><F><S><Q><L><F><I><Q><A><V><R><Q><T><L><S><T><P><G><T><I><I><L><G><T><I><P><V><P><K><G><K><P><L><A><L><V><E><E><I><R><N><R><K><D><V><K><V><F><N><V><T><K><E><N><R><N><H><L><L><P><D><I><V><T><C><V><Q><S><S><R><K>
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.<BOP>
Q9BSD7
A0A087WW87
KV240_HUMAN
Immunoglobulin kappa variable 2-40
Homo
<M><R><L><P><A><Q><L><L><G><L><L><M><L><W><V><P><G><S><S><E><D><I><V><M><T><Q><T><P><L><S><L><P><V><T><P><G><E><P><A><S><I><S><C><R><S><S><Q><S><L><L><D><S><D><D><G><N><T><Y><L><D><W><Y><L><Q><K><P><G><Q><S><P><Q><L><L><I><Y><T><L><S><Y><R><A><S><G><V><P><D><R><F><S><G><S><G><S><G><T><D><F><T><L><K><I><S><R><V><E><A><E><D><V><G><V><Y><Y><C><M><Q><R><I><E><F><P>
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0A087WW87
Q96PE5
OPALI_HUMAN
Transmembrane protein 10
Homo
<M><S><F><S><L><N><F><T><L><P><A><N><T><T><S><S><P><V><T><G><G><K><E><T><D><C><G><P><S><L><G><L><A><A><G><I><P><L><L><V><A><T><A><L><L><V><A><L><L><F><T><L><I><H><R><R><R><S><S><I><E><A><M><E><E><S><D><R><P><C><E><I><S><E><I><D><D><N><P><K><I><S><E><N><P><R><R><S><P><T><H><E><K><N><T><M><G><A><Q><E><A><H><I><Y><V><K><T><V><A><G><S><E><E><P><V><H><D><R><Y><R><P><T><I><E><M><E><R><R><R><G><L><W><W><L><V><P><R><L><S><L><E>
Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.<BOP>
Q96PE5
P06731
CEAM5_HUMAN
Meconium antigen 100
Homo
<M><E><S><P><S><A><P><P><H><R><W><C><I><P><W><Q><R><L><L><L><T><A><S><L><L><T><F><W><N><P><P><T><T><A><K><L><T><I><E><S><T><P><F><N><V><A><E><G><K><E><V><L><L><L><V><H><N><L><P><Q><H><L><F><G><Y><S><W><Y><K><G><E><R><V><D><G><N><R><Q><I><I><G><Y><V><I><G><T><Q><Q><A><T><P><G><P><A><Y><S><G><R><E><I><I><Y><P><N><A><S><L><L><I><Q><N><I><I><Q><N><D><T><G><F><Y><T><L><H><V><I><K><S><D><L><V><N><E><E><A><T><G><Q><F><R><V><Y><P><E><L><P><K><P><S><I><S><S><N><N><S><K><P><V><E><D><K><D><A><V><A><F><T><C><E><P><E><T><Q><D><A><T><Y><L><W><W><V><N><N><Q><S><L><P><V><S><P><R><L><Q><L><S><N><G><N><R><T><L><T><L><F><N><V><T><R><N><D><T><A><S><Y><K><C><E><T><Q><N><P><V><S><A><R><R><S><D><S><V><I><L><N><V><L><Y><G><P><D><A><P><T><I><S><P><L><N><T><S><Y><R><S><G><E><N><L><N><L><S><C><H><A><A><S><N><P><P><A><Q><Y><S><W><F><V><N><G><T><F><Q><Q><S><T><Q><E><L><F><I><P><N><I><T><V><N><N><S><G><S><Y><T><C><Q><A><H><N><S><D><T><G><L><N><R><T><T><V><T><T><I><T><V><Y><A><E><P><P><K><P><F><I><T><S><N><N><S><N><P><V><E><D><E><D><A><V><A><L><T><C><E><P><E><I><Q><N><T><T><Y><L><W><W><V><N><N><Q><S><L><P><V><S><P><R><L><Q><L><S><N><D><N><R><T><L><T><L><L><S><V><T><R><N><D><V><G><P><Y><E><C><G><I><Q><N><E><L><S><V><D><H><S><D><P><V><I><L><N><V><L><Y><G><P><D><D><P><T><I><S><P><S><Y><T><Y><Y><R><P><G><V><N><L><S><L><S><C><H><A><A><S><N><P><P><A><Q><Y><S><W><L><I><D><G><N><I><Q><Q><H><T><Q><E><L><F><I><S><N><I><T><E><K><N><S><G><L><Y><T><C><Q><A><N><N><S><A><S><G><H><S><R><T><T><V><K><T><I><T><V><S><A><E><L><P><K><P><S><I><S><S><N><N><S><K><P><V><E><D><K><D><A><V><A><F><T><C><E><P><E><A><Q><N><T><T><Y><L><W><W><V><N><G><Q><S><L><P><V><S><P><R><L><Q><L><S><N><G><N><R><T><L><T><L><F><N><V><T><R><N><D><A><R><A><Y><V><C><G><I><Q><N><S><V><S><A><N><R><S><D><P><V><T><L><D><V><L><Y><G><P><D><T><P><I><I><S><P><P><D><S><S><Y><L><S><G><A><N><L><N><L><S><C><H><S><A><S><N><P><S><P><Q><Y><S><W><R><I><N><G><I><P><Q><Q><H><T><Q><V><L><F><I><A><K><I><T><P><N><N><N><G><T><Y><A><C><F><V><S><N><L><A><T><G><R><N><N><S><I><V><K><S><I><T><V><S><A><S><G><T><S><P><G><L><S><A><G><A><T><V><G><I><M><I><G><V><L><V><G><V><A><L><I>
(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.<BOP>
P06731
Q9NWY4
HPF1_HUMAN
Histone PARylation factor 1
Homo
<M><V><G><G><G><G><K><R><R><P><G><G><E><G><P><Q><C><E><K><T><T><D><V><K><K><S><K><F><C><E><A><D><V><S><S><D><L><R><K><E><V><E><N><H><Y><K><L><S><L><P><E><D><F><Y><H><F><W><K><F><C><E><E><L><D><P><E><K><P><S><D><S><L><S><A><S><L><G><L><Q><L><V><G><P><Y><D><I><L><A><G><K><H><K><T><K><K><K><S><T><G><L><N><F><N><L><H><W><R><F><Y><Y><D><P><P><E><F><Q><T><I><I><I><G><D><N><K><T><Q><Y><H><M><G><Y><F><R><D><S><P><D><E><F><P><V><Y><V><G><I><N><E><A><K><K><N><C><I><I><V><P><N><G><D><N><V><F><A><A><V><K><L><F><L><T><K><K><L><R><E><I><T><D><K><K><K><I><N><L><L><K><N><I><D><E><K><L><T><E><A><A><R><E><L><G><Y><S><L><E><Q><R><T><V><K><M><K><Q><R><D><K><K><V><V><T><K><T><F><H><G><A><G><L><V><V><P><V><D><K><N><D><V><G><Y><R><E><L><P><E><T><D><A><D><L><K><R><I><C><K><T><I><V><E><A><A><S><D><E><E><R><L><K><A><F><A><P><I><Q><E><M><M><T><F><V><Q><F><A><N><D><E><C><D><Y><G><M><G><L><E><L><G><M><D><L><F><C><Y><G><S><H><Y><F><H><K><V><A><G><Q><L><L><P><L><A><Y><N><L><L><K><R><N><L><F><A><E><I><I><E><E><H><L><A><N><R><S><Q><E><N><I><D><Q><L><A><A>
Cofactor for serine ADP-ribosylation that confers serine specificity on PARP1 and PARP2 and plays a key role in DNA damage response . Initiates the repair of double-strand DNA breaks: recruited to DNA damage sites by PARP1 and PARP2 and switches the amino acid specificity of PARP1 and PARP2 from aspartate or glutamate to serine residues, licensing serine ADP-ribosylation of target proteins . Serine ADP-ribosylation of target proteins, such as histones, promotes decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks . Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage . HPF1 acts by completing the active site of PARP1 and PARP2: forms a composite active site composed of residues from HPF1 and PARP1 or PARP2 . While HPF1 promotes the initiation of serine ADP-ribosylation, it restricts the polymerase activity of PARP1 and PARP2 in order to limit the length of poly-ADP-ribose chains . HP
Q9NWY4
P08621
RU17_HUMAN
U1 small nuclear ribonucleoprotein 70 kDa
Homo
<M><T><Q><F><L><P><P><N><L><L><A><L><F><A><P><R><D><P><I><P><Y><L><P><P><L><E><K><L><P><H><E><K><H><H><N><Q><P><Y><C><G><I><A><P><Y><I><R><E><F><E><D><P><R><D><A><P><P><P><T><R><A><E><T><R><E><E><R><M><E><R><K><R><R><E><K><I><E><R><R><Q><Q><E><V><E><T><E><L><K><M><W><D><P><H><N><D><P><N><A><Q><G><D><A><F><K><T><L><F><V><A><R><V><N><Y><D><T><T><E><S><K><L><R><R><E><F><E><V><Y><G><P><I><K><R><I><H><M><V><Y><S><K><R><S><G><K><P><R><G><Y><A><F><I><E><Y><E><H><E><R><D><M><H><S><A><Y><K><H><A><D><G><K><K><I><D><G><R><R><V><L><V><D><V><E><R><G><R><T><V><K><G><W><R><P><R><R><L><G><G><G><L><G><G><T><R><R><G><G><A><D><V><N><I><R><H><S><G><R><D><D><T><S><R><Y><D><E><R><P><G><P><S><P><L><P><H><R><D><R><D><R><D><R><E><R><E><R><R><E><R><S><R><E><R><D><K><E><R><E><R><R><R><S><R><S><R><D><R><R><R><R><S><R><S><R><D><K><E><E><R><R><R><S><R><E><R><S><K><D><K><D><R><D><R><K><R><R><S><S><R><S><R><E><R><A><R><R><E><R><E><R><K><E><E><L><R><G><G><G><G><D><M><A><E><P><S><E><A><G><D><A><P><P><D><D><G><P><P><G><E><L><G><P><D><G><P><D><G><P><E><E><K><G><R><D><R><D><R><E><R><R><R><S><H><R><S><E><R><E><R><R><R><D><R><D><R><D><R><D><R><D><R><E><H><K><R><G><E><R><G><S><E><R><G><R><D><E><A><R><G><G><G><G><G><Q><D><N><G><L><E><G><L><G><N><D><S><R><D><M><Y><M><E><S><E><G><G><D><G><Y><L><A><P><E><N><G><Y><L><M><E><A><A><P><E>
Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.<BOP>
P08621
O00505
IMA4_HUMAN
SRP1-gamma
Homo
<M><A><E><N><P><S><L><E><N><H><R><I><K><S><F><K><N><K><G><R><D><V><E><T><M><R><R><H><R><N><E><V><T><V><E><L><R><K><N><K><R><D><E><H><L><L><K><K><R><N><V><P><Q><E><E><S><L><E><D><S><D><V><D><A><D><F><K><A><Q><N><V><T><L><E><A><I><L><Q><N><A><T><S><D><N><P><V><V><Q><L><S><A><V><Q><A><A><R><K><L><L><S><S><D><R><N><P><P><I><D><D><L><I><K><S><G><I><L><P><I><L><V><K><C><L><E><R><D><D><N><P><S><L><Q><F><E><A><A><W><A><L><T><N><I><A><S><G><T><S><A><Q><T><Q><A><V><V><Q><S><N><A><V><P><L><F><L><R><L><L><R><S><P><H><Q><N><V><C><E><Q><A><V><W><A><L><G><N><I><I><G><D><G><P><Q><C><R><D><Y><V><I><S><L><G><V><V><K><P><L><L><S><F><I><S><P><S><I><P><I><T><F><L><R><N><V><T><W><V><I><V><N><L><C><R><N><K><D><P><P><P><P><M><E><T><V><Q><E><I><L><P><A><L><C><V><L><I><Y><H><T><D><I><N><I><L><V><D><T><V><W><A><L><S><Y><L><T><D><G><G><N><E><Q><I><Q><M><V><I><D><S><G><V><V><P><F><L><V><P><L><L><S><H><Q><E><V><K><V><Q><T><A><A><L><R><A><V><G><N><I><V><T><G><T><D><E><Q><T><Q><V><V><L><N><C><D><V><L><S><H><F><P><N><L><L><S><H><P><K><E><K><I><N><K><E><A><V><W><F><L><S><N><I><T><A><G><N><Q><Q><Q><V><Q><A><V><I><D><A><G><L><I><P><M><I><I><H><Q><L><A><K><G><D><F><G><T><Q><K><E><A><A><W><A><I><S><N><L><T><I><S><G><R><K><D><Q><V><E><Y><L><V><Q><Q><N><V><I><P><P><F><C><N><L><L><S><V><K><D><S><Q><V><V><Q><V><V><L><D><G><L><K><N><I><L><I><M><A><G><D><E><A><S><T><I><A><E><I><I><E><E><C><G><G><L><E><K><I><E><V><L><Q><Q><H><E><N><E><D><I><Y><K><L><A><F><E><I><I><D><Q><Y><F><S><G><D><D><I><D><E><D><P><C><L><I><P><E><A><T><Q><G><G><T><Y><N><F><D><P><T><A><N><L><Q><T><K><E><F><N><F>
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.<BOP>
O00505
Q9GZS3
WDR61_HUMAN
WD repeat-containing protein 61, N-terminally processed
Homo
<M><T><N><Q><Y><G><I><L><F><K><Q><E><Q><A><H><D><D><A><I><W><S><V><A><W><G><T><N><K><K><E><N><S><E><T><V><V><T><G><S><L><D><D><L><V><K><V><W><K><W><R><D><E><R><L><D><L><Q><W><S><L><E><G><H><Q><L><G><V><V><S><V><D><I><S><H><T><L><P><I><A><A><S><S><S><L><D><A><H><I><R><L><W><D><L><E><N><G><K><Q><I><K><S><I><D><A><G><P><V><D><A><W><T><L><A><F><S><P><D><S><Q><Y><L><A><T><G><T><H><V><G><K><V><N><I><F><G><V><E><S><G><K><K><E><Y><S><L><D><T><R><G><K><F><I><L><S><I><A><Y><S><P><D><G><K><Y><L><A><S><G><A><I><D><G><I><I><N><I><F><D><I><A><T><G><K><L><L><H><T><L><E><G><H><A><M><P><I><R><S><L><T><F><S><P><D><S><Q><L><L><V><T><A><S><D><D><G><Y><I><K><I><Y><D><V><Q><H><A><N><L><A><G><T><L><S><G><H><A><S><W><V><L><N><V><A><F><C><P><D><D><T><H><F><V><S><S><S><S><D><K><S><V><K><V><W><D><V><G><T><R><T><C><V><H><T><F><F><D><H><Q><D><Q><V><W><G><V><K><Y><N><G><N><G><S><K><I><V><S><V><G><D><D><Q><E><I><H><I><Y><D><C><P><I>
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H
Q9GZS3
Q16555
DPYL2_HUMAN
Unc-33-like phosphoprotein 2
Homo
<M><S><Y><Q><G><K><K><N><I><P><R><I><T><S><D><R><L><L><I><K><G><G><K><I><V><N><D><D><Q><S><F><Y><A><D><I><Y><M><E><D><G><L><I><K><Q><I><G><E><N><L><I><V><P><G><G><V><K><T><I><E><A><H><S><R><M><V><I><P><G><G><I><D><V><H><T><R><F><Q><M><P><D><Q><G><M><T><S><A><D><D><F><F><Q><G><T><K><A><A><L><A><G><G><T><T><M><I><I><D><H><V><V><P><E><P><G><T><S><L><L><A><A><F><D><Q><W><R><E><W><A><D><S><K><S><C><C><D><Y><S><L><H><V><D><I><S><E><W><H><K><G><I><Q><E><E><M><E><A><L><V><K><D><H><G><V><N><S><F><L><V><Y><M><A><F><K><D><R><F><Q><L><T><D><C><Q><I><Y><E><V><L><S><V><I><R><D><I><G><A><I><A><Q><V><H><A><E><N><G><D><I><I><A><E><E><Q><Q><R><I><L><D><L><G><I><T><G><P><E><G><H><V><L><S><R><P><E><E><V><E><A><E><A><V><N><R><A><I><T><I><A><N><Q><T><N><C><P><L><Y><I><T><K><V><M><S><K><S><S><A><E><V><I><A><Q><A><R><K><K><G><T><V><V><Y><G><E><P><I><T><A><S><L><G><T><D><G><S><H><Y><W><S><K><N><W><A><K><A><A><A><F><V><T><S><P><P><L><S><P><D><P><T><T><P><D><F><L><N><S><L><L><S><C><G><D><L><Q><V><T><G><S><A><H><C><T><F><N><T><A><Q><K><A><V><G><K><D><N><F><T><L><I><P><E><G><T><N><G><T><E><E><R><M><S><V><I><W><D><K><A><V><V><T><G><K><M><D><E><N><Q><F><V><A><V><T><S><T><N><A><A><K><V><F><N><L><Y><P><R><K><G><R><I><A><V><G><S><D><A><D><L><V><I><W><D><P><D><S><V><K><T><I><S><A><K><T><H><N><S><S><L><E><Y><N><I><F><E><G><M><E><C><R><G><S><P><L><V><V><I><S><Q><G><K><I><V><L><E><D><G><T><L><H><V><T><E><G><S><G><R><Y><I><P><R><K><P><F><P><D><F><V><Y><K><R><I><K><A><R><S><R><L><A><E><L><R><G><V><P><R><G><L><Y><D><G><P><V><C><E><V><S><V><T><P><K><T><V><T><P><A><S><S><A><K><T><S><P><A><K><Q><Q><A><P><P><V><R><N><L><H><Q><S><G><F><S><L><S><G><A><Q><I><D><D><N><I><P><R><R><T><T><Q><R><I><V><A><P><P><G><G><R><A><N><I><T><S><L><G>
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.<BOP>
Q16555
Q9UHI7
S23A1_HUMAN
Yolk sac permease-like molecule 3
Homo
<M><R><A><Q><E><D><L><E><G><R><T><Q><H><E><T><T><R><D><P><S><T><P><L><P><T><E><P><K><F><D><M><L><Y><K><I><E><D><V><P><P><W><Y><L><C><I><L><L><G><F><Q><H><Y><L><T><C><F><S><G><T><I><A><V><P><F><L><L><A><E><A><L><C><V><G><H><D><Q><H><M><V><S><Q><L><I><G><T><I><F><T><C><V><G><I><T><T><L><I><Q><T><T><V><G><I><R><L><P><L><F><Q><A><S><A><F><A><F><L><V><P><A><K><A><I><L><A><L><E><R><W><K><C><P><P><E><E><E><I><Y><G><N><W><S><L><P><L><N><T><S><H><I><W><H><P><R><I><R><E><V><Q><G><A><I><M><V><S><S><V><V><E><V><V><I><G><L><L><G><L><P><G><A><L><L><N><Y><I><G><P><L><T><V><T><P><T><V><S><L><I><G><L><S><V><F><Q><A><A><G><D><R><A><G><S><H><W><G><I><S><A><C><S><I><L><L><I><I><L><F><S><Q><Y><L><R><N><L><T><F><L><L><P><V><Y><R><W><G><K><G><L><T><L><L><R><I><Q><I><F><K><M><F><P><I><M><L><A><I><M><T><V><W><L><L><C><Y><V><L><T><L><T><D><V><L><P><T><D><P><K><A><Y><G><F><Q><A><R><T><D><A><R><G><D><I><M><A><I><A><P><W><I><R><I><P><Y><P><C><Q><W><G><L><P><T><V><T><A><A><A><V><L><G><M><F><S><A><T><L><A><G><I><I><E><S><I><G><D><Y><Y><A><C><A><R><L><A><G><A><P><P><P><P><V><H><A><I><N><R><G><I><F><T><E><G><I><C><C><I><I><A><G><L><L><G><T><G><N><G><S><T><S><S><S><P><N><I><G><V><L><G><I><T><K><V><G><S><R><R><V><V><Q><Y><G><A><A><I><M><L><V><L><G><T><I><G><K><F><T><A><L><F><A><S><L><P><D><P><I><L><G><G><M><F><C><T><L><F><G><M><I><T><A><V><G><L><S><N><L><Q><F><V><D><M><N><S><S><R><N><L><F><V><L><G><F><S><M><F><F><G><L><T><L><P><N><Y><L><E><S><N><P><G><A><I><N><T><G><I><L><E><V><D><Q><I><L><I><V><L><L><T><T><E><M><F><V><G><G><C><L><A><F><I><L><D><N><T><V><P><G><S><P><E><E><R><G><L><I><Q><W><K><A><G><A><H><A><N><S><D><M><S><S><S><L><K><S><Y><D><F><P><I><G><M><G><I><V><K><R><I><T><F><L><K><Y><I><P><I><C><P><V><F><K><G><F><S><S><S><S><K><D><Q><I><A><I><P><E><D><T><P><E><N><T><E><T><A><S><V><C><T><K><V>
Inactive transporter.<BOP>
Q9UHI7
Q96RD7
PANX1_HUMAN
Pannexin-1
Homo
<M><A><I><A><Q><L><A><T><E><Y><V><F><S><D><F><L><L><K><E><P><T><E><P><K><F><K><G><L><R><L><E><L><A><V><D><K><M><V><T><C><I><A><V><G><L><P><L><L><L><I><S><L><A><F><A><Q><E><I><S><I><G><T><Q><I><S><C><F><S><P><S><S><F><S><W><R><Q><A><A><F><V><D><S><Y><C><W><A><A><V><Q><Q><K><N><S><L><Q><S><E><S><G><N><L><P><L><W><L><H><K><F><F><P><Y><I><L><L><L><F><A><I><L><L><Y><L><P><P><L><F><W><R><F><A><A><A><P><H><I><C><S><D><L><K><F><I><M><E><E><L><D><K><V><Y><N><R><A><I><K><A><A><K><S><A><R><D><L><D><M><R><D><G><A><C><S><V><P><G><V><T><E><N><L><G><Q><S><L><W><E><V><S><E><S><H><F><K><Y><P><I><V><E><Q><Y><L><K><T><K><K><N><S><N><N><L><I><I><K><Y><I><S><C><R><L><L><T><L><I><I><I><L><L><A><C><I><Y><L><G><Y><Y><F><S><L><S><S><L><S><D><E><F><V><C><S><I><K><S><G><I><L><R><N><D><S><T><V><P><D><Q><F><Q><C><K><L><I><A><V><G><I><F><Q><L><L><S><V><I><N><L><V><V><Y><V><L><L><A><P><V><V><V><Y><T><L><F><V><P><F><R><Q><K><T><D><V><L><K><V><Y><E><I><L><P><T><F><D><V><L><H><F><K><S><E><G><Y><N><D><L><S><L><Y><N><L><F><L><E><E><N><I><S><E><V><K><S><Y><K><C><L><K><V><L><E><N><I><K><S><S><G><Q><G><I><D><P><M><L><L><L><T><N><L><G><M><I><K><M><D><V><V><D><G><K><T><P><M><S><A><E><M><R><E><E><Q><G><N><Q><T><A><E><L><Q><G><M><N><I><D><S><E><T><K><A><N><N><G><E><K><N><A><R><Q><R><L><L><D><S><S><C>
Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation . May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis . Plays a critical role in oogenesis .<BOP>
Q96RD7
O15533
TPSN_HUMAN
TAP-binding protein
Homo
<M><K><S><L><S><L><L><L><A><V><A><L><G><L><A><T><A><V><S><A><G><P><A><V><I><E><C><W><F><V><E><D><A><S><G><K><G><L><A><K><R><P><G><A><L><L><L><R><Q><G><P><G><E><P><P><P><R><P><D><L><D><P><E><L><Y><L><S><V><H><D><P><A><G><A><L><Q><A><A><F><R><R><Y><P><R><G><A><P><A><P><H><C><E><M><S><R><F><V><P><L><P><A><S><A><K><W><A><S><G><L><T><P><A><Q><N><C><P><R><A><L><D><G><A><W><L><M><V><S><I><S><S><P><V><L><S><L><S><S><L><L><R><P><Q><P><E><P><Q><Q><E><P><V><L><I><T><M><A><T><V><V><L><T><V><L><T><H><T><P><A><P><R><V><R><L><G><Q><D><A><L><L><D><L><S><F><A><Y><M><P><P><T><S><E><A><A><S><S><L><A><P><G><P><P><P><F><G><L><E><W><R><R><Q><H><L><G><K><G><H><L><L><L><A><A><T><P><G><L><N><G><Q><M><P><A><A><Q><E><G><A><V><A><F><A><A><W><D><D><D><E><P><W><G><P><W><T><G><N><G><T><F><W><L><P><T><V><Q><P><F><Q><E><G><T><Y><L><A><T><I><H><L><P><Y><L><Q><G><Q><V><T><L><E><L><A><V><Y><K><P><P><K><V><S><L><M><P><A><T><L><A><R><A><A><P><G><E><A><P><P><E><L><L><C><L><V><S><H><F><Y><P><S><G><G><L><E><V><E><W><E><L><R><G><G><P><G><G><R><S><Q><K><A><E><G><Q><R><W><L><S><A><L><R><H><H><S><D><G><S><V><S><L><S><G><H><L><Q><P><P><P><V><T><T><E><Q><H><G><A><R><Y><A><C><R><I><H><H><P><S><L><P><A><S><G><R><S><A><E><V><T><L><E><V><A><G><L><S><G><P><S><L><E><D><S><V><G><L><F><L><S><A><F><L><L><L><G><L><F><K><A><L><G><W><A><A><V><Y><L><S><T><C><K><D><S><K><K><K><A><E>
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).<BOP>
O15533
A0A0B4J2E0
TVBL4_HUMAN
T cell receptor beta variable 12-4
Homo
<M><G><S><W><T><L><C><C><V><S><L><C><I><L><V><A><K><H><T><D><A><G><V><I><Q><S><P><R><H><E><V><T><E><M><G><Q><E><V><T><L><R><C><K><P><I><S><G><H><D><Y><L><F><W><Y><R><Q><T><M><M><R><G><L><E><L><L><I><Y><F><N><N><N><V><P><I><D><D><S><G><M><P><E><D><R><F><S><A><K><M><P><N><A><S><F><S><T><L><K><I><Q><P><S><E><P><R><D><S><A><V><Y><F><C><A><S><S><L>
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A0B4J2E0
Q7Z601
GP142_HUMAN
G-protein coupled receptor PGR2
Homo
<M><S><I><M><M><L><P><M><E><Q><K><I><Q><W><V><P><T><S><L><Q><D><I><T><A><V><L><G><T><E><A><Y><T><E><E><D><K><S><M><V><S><H><A><Q><K><S><Q><H><S><C><L><S><H><S><R><W><L><R><S><P><Q><V><T><G><G><S><W><D><L><R><I><R><P><S><K><D><S><S><S><F><R><Q><A><Q><C><L><R><K><D><P><G><A><N><N><H><L><E><S><Q><G><V><R><G><T><A><G><D><A><D><R><E><L><R><G><P><S><E><K><A><T><A><G><Q><P><R><V><T><L><L><P><T><P><H><V><S><G><L><S><Q><E><F><E><S><H><W><P><E><I><A><E><R><S><P><C><V><A><G><V><I><P><V><I><Y><Y><S><V><L><L><G><L><G><L><P><V><S><L><L><T><A><V><A><L><A><R><L><A><T><R><T><R><R><P><S><Y><Y><Y><L><L><A><L><T><A><S><D><I><I><I><Q><V><V><I><V><F><A><G><F><L><L><Q><G><A><V><L><A><R><Q><V><P><Q><A><V><V><R><T><A><N><I><L><E><F><A><A><N><H><A><S><V><W><I><A><I><L><L><T><V><D><R><Y><T><A><L><C><H><P><L><H><H><R><A><A><S><S><P><G><R><T><R><R><A><I><A><A><V><L><S><A><A><L><L><T><G><I><P><F><Y><W><W><L><D><M><W><R><D><T><D><S><P><R><T><L><D><E><V><L><K><W><A><H><C><L><T><V><Y><F><I><P><C><G><V><F><L><V><T><N><S><A><I><I><H><R><L><R><R><R><G><R><S><G><L><Q><P><R><V><G><K><S><T><A><I><L><L><G><I><T><T><L><F><T><L><L><W><A><P><R><V><F><V><M><L><Y><H><M><Y><V><A><P><V><H><R><D><W><R><V><H><L><A><L><D><V><A><N><M><V><A><M><L><H><T><A><A><N><F><G><L><Y><C><F><V><S><K><T><F><R><A><T><V><R><Q><V><I><H><D><A><Y><L><P><C><T><L><A><S><Q><P><E><G><M><A><A><K><P><V><M><E><P><P><G><L><P><T><G><A><E><V>
Orphan receptor.<BOP>
Q7Z601
Q9BWG6
SCNM1_HUMAN
Sodium channel modifier 1
Homo
<M><S><F><K><R><E><G><D><D><W><S><Q><L><N><V><L><K><K><R><R><V><G><D><L><L><A><S><Y><I><P><E><D><E><A><L><M><L><R><D><G><R><F><A><C><A><I><C><P><H><R><P><V><L><D><T><L><A><M><L><T><A><H><R><A><G><K><K><H><L><S><S><L><Q><L><F><Y><G><K><K><Q><P><G><K><E><R><K><Q><N><P><K><H><Q><N><E><L><R><R><E><E><T><K><A><E><A><P><L><L><T><Q><T><R><L><I><T><Q><S><A><L><H><R><A><P><H><Y><N><S><C><C><R><R><K><Y><R><P><E><A><P><G><P><S><V><S><L><S><P><M><P><P><S><E><V><K><L><Q><S><G><K><I><S><R><E><P><E><P><A><A><G><P><Q><A><E><E><S><A><T><V><S><A><P><A><P><M><S><P><T><R><R><R><A><L><D><H><Y><L><T><L><R><S><S><G><W><I><P><D><G><R><G><R><W><V><K><D><E><N><V><E><F><D><S><D><E><E><E><P><P><D><L><P><L><D>
Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.<BOP>
Q9BWG6
Q3YBR2
TBRG1_HUMAN
Nuclear interactor of ARF and Mdm2
Homo
<M><S><L><L><D><G><L><A><S><S><P><R><A><P><L><Q><S><S><K><A><R><M><K><K><L><P><K><K><S><Q><N><E><K><Y><R><L><K><Y><L><R><L><R><K><A><A><K><A><T><V><F><E><N><A><A><I><C><D><E><I><A><R><L><E><E><K><F><L><K><A><K><E><E><R><R><Y><L><L><K><K><L><L><Q><L><Q><A><L><T><E><G><E><V><Q><A><A><A><P><S><H><S><S><S><L><P><L><T><Y><G><V><A><S><S><V><G><T><I><Q><G><A><G><P><I><S><G><P><S><T><G><A><E><E><P><F><G><K><K><T><K><K><E><K><K><E><K><G><K><E><N><N><K><L><E><V><L><K><K><T><C><K><K><K><K><M><A><G><G><A><R><K><L><V><Q><P><I><A><L><D><P><S><G><R><P><V><F><P><I><G><L><G><G><L><T><V><Y><S><L><G><E><I><I><T><D><R><P><G><F><H><D><E><S><A><I><Y><P><V><G><Y><C><S><T><R><I><Y><A><S><M><K><C><P><D><Q><K><C><L><Y><T><C><Q><I><K><D><G><G><V><Q><P><Q><F><E><I><V><P><E><D><D><P><Q><N><A><I><V><S><S><S><A><D><A><C><H><A><E><L><L><R><T><I><S><T><T><M><G><K><L><M><P><N><L><L><P><A><G><A><D><F><F><G><F><S><H><P><A><I><H><N><L><I><Q><S><C><P><G><A><R><K><C><I><N><Y><Q><W><V><K><F><D><V><C><K><P><G><D><G><Q><L><P><E><G><L><P><E><N><D><A><A><M><S><F><E><A><F><Q><R><Q><I><F><D><E><D><Q><N><D><P><L><L><P><G><S><L><D><L><P><E><L><Q><P><A><A><F><V><S><S><Y><Q><P><M><Y><L><T><H><E><P><L><V><D><T><H><L><Q><H><L><K><S><P><S><Q><G><S><P><I><Q><S><S><D>
Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.<BOP>
Q3YBR2
Q96QV6
H2A1A_HUMAN
Histone H2A/r
Homo
<M><S><G><R><G><K><Q><G><G><K><A><R><A><K><S><K><S><R><S><S><R><A><G><L><Q><F><P><V><G><R><I><H><R><L><L><R><K><G><N><Y><A><E><R><I><G><A><G><A><P><V><Y><L><A><A><V><L><E><Y><L><T><A><E><I><L><E><L><A><G><N><A><S><R><D><N><K><K><T><R><I><I><P><R><H><L><Q><L><A><I><R><N><D><E><E><L><N><K><L><L><G><G><V><T><I><A><Q><G><G><V><L><P><N><I><Q><A><V><L><L><P><K><K><T><E><S><H><H><H><K><A><Q><S><K>
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<BOP>
Q96QV6
Q13516
OLIG2_HUMAN
Protein kinase C-binding protein RACK17
Homo
<M><D><S><D><A><S><L><V><S><S><R><P><S><S><P><E><P><D><D><L><F><L><P><A><R><S><K><G><S><S><G><S><A><F><T><G><G><T><V><S><S><S><T><P><S><D><C><P><P><E><L><S><A><E><L><R><G><A><M><G><S><A><G><A><H><P><G><D><K><L><G><G><S><G><F><K><S><S><S><S><S><T><S><S><S><T><S><S><A><A><A><S><S><T><K><K><D><K><K><Q><M><T><E><P><E><L><Q><Q><L><R><L><K><I><N><S><R><E><R><K><R><M><H><D><L><N><I><A><M><D><G><L><R><E><V><M><P><Y><A><H><G><P><S><V><R><K><L><S><K><I><A><T><L><L><L><A><R><N><Y><I><L><M><L><T><N><S><L><E><E><M><K><R><L><V><S><E><I><Y><G><G><H><H><A><G><F><H><P><S><A><C><G><G><L><A><H><S><A><P><L><P><A><A><T><A><H><P><A><A><A><A><H><A><A><H><H><P><A><V><H><H><P><I><L><P><P><A><A><A><A><A><A><A><A><A><A><A><A><A><V><S><S><A><S><L><P><G><S><G><L><P><S><V><G><S><I><R><P><P><H><G><L><L><K><S><P><S><A><A><A><A><A><P><L><G><G><G><G><G><G><S><G><A><S><G><G><F><Q><H><W><G><G><M><P><C><P><C><S><M><C><Q><V><P><P><P><H><H><H><V><S><A><M><G><A><G><S><L><P><R><L><T><S><D><A><K>
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.<BOP>
Q13516
Q9UJQ1
LAMP5_HUMAN
Lysosome-associated membrane protein 5
Homo
<M><D><L><Q><G><R><G><V><P><S><I><D><R><L><R><V><L><L><M><L><F><H><T><M><A><Q><I><M><A><E><Q><E><V><E><N><L><S><G><L><S><T><N><P><E><K><D><I><F><V><V><R><E><N><G><T><T><C><L><M><A><E><F><A><A><K><F><I><V><P><Y><D><V><W><A><S><N><Y><V><D><L><I><T><E><Q><A><D><I><A><L><T><R><G><A><E><V><K><G><R><C><G><H><S><Q><S><E><L><Q><V><F><W><V><D><R><A><Y><A><L><K><M><L><F><V><K><E><S><H><N><M><S><K><G><P><E><A><T><W><R><L><S><K><V><Q><F><V><Y><D><S><S><E><K><T><H><F><K><D><A><V><S><A><G><K><H><T><A><N><S><H><H><L><S><A><L><V><T><P><A><G><K><S><Y><E><C><Q><A><Q><Q><T><I><S><L><A><S><S><D><P><Q><K><T><V><T><M><I><L><S><A><V><H><I><Q><P><F><D><I><I><S><D><F><V><F><S><E><E><H><K><C><P><V><D><E><R><E><Q><L><E><E><T><L><P><L><I><L><G><L><I><L><G><L><V><I><M><V><T><L><A><I><Y><H><V><H><H><K><M><T><A><N><Q><V><Q><I><P><R><D><R><S><Q><Y><K><H><M><G>
Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.<BOP>
Q9UJQ1
P51397
DAP1_HUMAN
Death-associated protein 1
Homo
<M><S><S><P><P><E><G><K><L><E><T><K><A><G><H><P><P><A><V><K><A><G><G><M><R><I><V><Q><K><H><P><H><T><G><D><T><K><E><E><K><D><K><D><D><Q><E><W><E><S><P><S><P><P><K><P><T><V><F><I><S><G><V><I><A><R><G><D><K><D><F><P><P><A><A><A><Q><V><A><H><Q><K><P><H><A><S><M><D><K><H><P><S><P><R><T><Q><H><I><Q><Q><P><R><K>
Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.<BOP>
P51397
Q9Y244
POMP_HUMAN
Voltage-gated K channel beta subunit 4.1
Homo
<M><N><A><R><G><L><G><S><E><L><K><D><S><I><P><V><T><E><L><S><A><S><G><P><F><E><S><H><D><L><L><R><K><G><F><S><C><V><K><N><E><L><L><P><S><H><P><L><E><L><S><E><K><N><F><Q><L><N><Q><D><K><M><N><F><S><T><L><R><N><I><Q><G><L><F><A><P><L><K><L><Q><M><E><F><K><A><V><Q><Q><V><Q><R><L><P><F><L><S><S><S><N><L><S><L><D><V><L><R><G><N><D><E><T><I><G><F><E><D><I><L><N><D><P><S><Q><S><E><V><M><G><E><P><H><L><M><V><E><Y><K><L><G><L><L>
Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum.<BOP>
Q9Y244
Q9NQR4
NIT2_HUMAN
Nitrilase homolog 2
Homo
<M><T><S><F><R><L><A><L><I><Q><L><Q><I><S><S><I><K><S><D><N><V><T><R><A><C><S><F><I><R><E><A><A><T><Q><G><A><K><I><V><S><L><P><E><C><F><N><S><P><Y><G><A><K><Y><F><P><E><Y><A><E><K><I><P><G><E><S><T><Q><K><L><S><E><V><A><K><E><C><S><I><Y><L><I><G><G><S><I><P><E><E><D><A><G><K><L><Y><N><T><C><A><V><F><G><P><D><G><T><L><L><A><K><Y><R><K><I><H><L><F><D><I><D><V><P><G><K><I><T><F><Q><E><S><K><T><L><S><P><G><D><S><F><S><T><F><D><T><P><Y><C><R><V><G><L><G><I><C><Y><D><M><R><F><A><E><L><A><Q><I><Y><A><Q><R><G><C><Q><L><L><V><Y><P><G><A><F><N><L><T><T><G><P><A><H><W><E><L><L><Q><R><S><R><A><V><D><N><Q><V><Y><V><A><T><A><S><P><A><R><D><D><K><A><S><Y><V><A><W><G><H><S><T><V><V><N><P><W><G><E><V><L><A><K><A><G><T><E><E><A><I><V><Y><S><D><I><D><L><K><K><L><A><E><I><R><Q><Q><I><P><V><F><R><Q><K><R><S><D><L><Y><A><V><E><M><K><K><P>
Has omega-amidase activity . The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively .<BOP>
Q9NQR4
Q99471
PFD5_HUMAN
c-Myc-binding protein Mm-1
Homo
<M><A><Q><S><I><N><I><T><E><L><N><L><P><Q><L><E><M><L><K><N><Q><L><D><Q><E><V><E><F><L><S><T><S><I><A><Q><L><K><V><V><Q><T><K><Y><V><E><A><K><D><C><L><N><V><L><N><K><S><N><E><G><K><E><L><L><V><P><L><T><S><S><M><Y><V><P><G><K><L><H><D><V><E><H><V><L><I><D><V><G><T><G><Y><Y><V><E><K><T><A><E><D><A><K><D><F><F><K><R><K><I><D><F><L><T><K><Q><M><E><K><I><Q><P><A><L><Q><E><K><H><A><M><K><Q><A><V><M><E><M><M><S><Q><K><I><Q><Q><L><T><A><L><G><A><A><Q><A><T><A><K><A>
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.<BOP>
Q99471
P61758
PFD3_HUMAN
von Hippel-Lindau-binding protein 1
Homo
<M><A><A><V><K><D><S><C><G><K><G><E><M><A><T><G><N><G><R><R><L><H><L><G><I><P><E><A><V><F><V><E><D><V><D><S><F><M><K><Q><P><G><N><E><T><A><D><T><V><L><K><K><L><D><E><Q><Y><Q><K><Y><K><F><M><E><L><N><L><A><Q><K><K><R><R><L><K><G><Q><I><P><E><I><K><Q><T><L><E><I><L><K><Y><M><Q><K><K><K><E><S><T><N><S><M><E><T><R><F><L><L><A><D><N><L><Y><C><K><A><S><V><P><P><T><D><K><V><C><L><W><L><G><A><N><V><M><L><E><Y><D><I><D><E><A><Q><A><L><L><E><K><N><L><S><T><A><T><K><N><L><D><S><L><E><E><D><L><D><F><L><R><D><Q><F><T><T><T><E><V><N><M><A><R><V><Y><N><W><D><V><K><R><R><N><K><D><D><S><T><K><N><K><A>
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.<BOP>
P61758
Q8NFR9
I17RE_HUMAN
Interleukin-17 receptor E
Homo
<M><G><S><S><R><L><A><A><L><L><L><P><L><L><L><I><V><I><D><L><S><D><S><A><G><I><G><F><R><H><L><P><H><W><N><T><R><C><P><L><A><S><H><T><D><D><S><F><T><G><S><S><A><Y><I><P><C><R><T><W><W><A><L><F><S><T><K><P><W><C><V><R><V><W><H><C><S><R><C><L><C><Q><H><L><L><S><G><G><S><G><L><Q><R><G><L><F><H><L><L><V><Q><K><S><K><K><S><S><T><F><K><F><Y><R><R><H><K><M><P><A><P><A><Q><R><K><L><L><P><R><R><H><L><S><E><K><S><H><H><I><S><I><P><S><P><D><I><S><H><K><G><L><R><S><K><R><T><Q><P><S><D><P><E><T><W><E><S><L><P><R><L><D><S><Q><R><H><G><G><P><E><F><S><F><D><L><L><P><E><A><R><A><I><R><V><T><I><S><S><G><P><E><V><S><V><R><L><C><H><Q><W><A><L><E><C><E><E><L><S><S><P><Y><D><V><Q><K><I><V><S><G><G><H><T><V><E><L><P><Y><E><F><L><L><P><C><L><C><I><E><A><S><Y><L><Q><E><D><T><V><R><R><K><K><C><P><F><Q><S><W><P><E><A><Y><G><S><D><F><W><K><S><V><H><F><T><D><Y><S><Q><H><T><Q><M><V><M><A><L><T><L><R><C><P><L><K><L><E><A><A><L><C><Q><R><H><D><W><H><T><L><C><K><D><L><P><N><A><T><A><R><E><S><D><G><W><Y><V><L><E><K><V><D><L><H><P><Q><L><C><F><K><F><S><F><G><N><S><S><H><V><E><C><P><H><Q><T><G><S><L><T><S><W><N><V><S><M><D><T><Q><A><Q><Q><L><I><L><H><F><S><S><R><M><H><A><T><F><S><A><A><W><S><L><P><G><L><G><Q><D><T><L><V><P><P><V><Y><T><V><S><Q><A><R><G><S><S><P><V><S><L><D><L><I><I><P><F><L><R><P><G><C><C><V><L><V><W><R><S><D><V><Q><F><A><W><K><H><L><L><C><P><D><V><S><Y><R><H><L><G><L><L><I><L><A><L><L><A><L><L><T><L><L><G><V><V><L><A><L><T><C><R><R><P><Q><S><G><P><G><P><A><R><P><V><L><L><L><H><A><A><D><S><E><A><Q><R><R><L><V><G><A><L><A><E><L><L><R><A><A><L><G><G><G><R><D><V><I><V><D><L><W><E><G><R><H><V><A><R><V><G><P><L><P><W><L><W><A><A><R><T><R><V><A><R><E><Q><G><T><V><L><L><L><W><S><G><A><D><L><R><P><V><S><G><P><D><P><R><A><A><P><L><L><A><L><L><H><A><A><P><R><P><L><L><L><L><A><Y><F><S><R><L><C><A><K><G><D><I><P><P><P><L><R><A><L><P><R><Y><R><L><L><R><D><L><P><R><L><L><R><A><L><D><A><R><P><F><A><E><A><T><S><W><G><R><L><G><A><R><Q><R><R><Q><S><R><L><E><L><C><S><R><L><E><R><E><A><A><R><L><A><D><L><G>
Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.<BOP>
Q8NFR9
W6CW81
PYDC5_HUMAN
Pyrin domain-only protein 3
Homo
<M><E><S><K><Y><K><E><I><L><L><L><T><S><L><D><N><I><T><D><E><E><L><D><R><F><K><C><F><L><P><D><E><F><N><I><A><T><G><K><L><H><T><L><N><S><T><S><S><Q><L><D><L><K><R><W><H><G><V><C><S><E><E><D><R><I><F><Q><K><L><N><Y><M><L><V><A><K><C><L><R><E><E><Q><E><T><G><I><C><G><S><P><S><S><A><R><S><V><S><Q><S><R><L><G><L><S><F><H><G><I><S><G><N><A><C>
Functions as an inhibitor of DNA virus-induced activation of AIM2-like receptors (ALR) inflammasome through interaction with AIM2.<BOP>
W6CW81
P15514
AREG_HUMAN
Colorectum cell-derived growth factor
Homo
<M><R><A><P><L><L><P><P><A><P><V><V><L><S><L><L><I><L><G><S><G><H><Y><A><A><G><L><D><L><N><D><T><Y><S><G><K><R><E><P><F><S><G><D><H><S><A><D><G><F><E><V><T><S><R><S><E><M><S><S><G><S><E><I><S><P><V><S><E><M><P><S><S><S><E><P><S><S><G><A><D><Y><D><Y><S><E><E><Y><D><N><E><P><Q><I><P><G><Y><I><V><D><D><S><V><R><V><E><Q><V><V><K><P><P><Q><N><K><T><E><S><E><N><T><S><D><K><P><K><R><K><K><K><G><G><K><N><G><K><N><R><R><N><R><K><K><K><N><P><C><N><A><E><F><Q><N><F><C><I><H><G><E><C><K><Y><I><E><H><L><E><A><V><T><C><K><C><Q><Q><E><Y><F><G><E><R><C><G><E><K><S><M><K><T><H><S><M><I><D><S><S><L><S><K><I><A><L><A><A><I><A><A><F><M><S><A><V><I><L><T><A><V><A><V><I><T><V><Q><L><R><R><Q><Y><V><R><K><Y><E><G><E><A><E><E><R><K><K><L><R><Q><E><N><G><N><V><H><A><I><A>
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.<BOP>
P15514
Q9BPY3
F118B_HUMAN
Protein FAM118B
Homo
<M><A><S><T><G><S><Q><A><S><D><I><D><E><I><F><G><F><F><N><D><G><E><P><P><T><K><K><P><R><K><L><L><P><S><L><K><T><K><K><P><R><E><L><V><L><V><I><G><T><G><I><S><A><A><V><A><P><Q><V><P><A><L><K><S><W><K><G><L><I><Q><A><L><L><D><A><A><I><D><F><D><L><L><E><D><E><E><S><K><K><F><Q><K><C><L><H><E><D><K><N><L><V><H><V><A><H><D><L><I><Q><K><L><S><P><R><T><S><N><V><R><S><T><F><F><K><D><C><L><Y><E><V><F><D><D><L><E><S><K><M><E><D><S><G><K><Q><L><L><Q><S><V><L><H><L><M><E><N><G><A><L><V><L><T><T><N><F><D><N><L><L><E><L><Y><A><A><D><Q><G><K><Q><L><E><S><L><D><L><T><D><E><K><K><V><L><E><W><A><Q><E><K><R><K><L><S><V><L><H><I><H><G><V><Y><T><N><P><S><G><I><V><L><H><P><A><G><Y><Q><N><V><L><R><N><T><E><V><M><R><E><I><Q><K><L><Y><E><N><K><S><F><L><F><L><G><C><G><W><T><V><D><D><T><T><F><Q><A><L><F><L><E><A><V><K><H><K><S><D><L><E><H><F><M><L><V><R><R><G><D><V><D><E><F><K><K><L><R><E><N><M><L><D><K><G><I><K><V><I><S><Y><G><D><D><Y><A><D><L><P><E><Y><F><K><R><L><T><C><E><I><S><T><R><G><T><S><A><G><M><V><R><E><G><Q><L><N><G><S><S><A><A><H><S><E><I><R><G><C><S><T>
May play a role in Cajal bodies formation.<BOP>
Q9BPY3
Q02325
PLGB_HUMAN
Plasminogen-related protein B
Homo
<M><E><H><K><E><V><V><L><L><L><L><L><F><L><K><S><G><Q><G><E><P><L><D><D><Y><V><N><T><Q><G><P><S><L><F><S><V><T><K><K><Q><L><G><A><G><S><R><E><E><C><A><A><K><C><E><E><D><K><E><F><T><C><R><A><F><Q><Y><H><S><K><E><Q><Q><C><V><I><M><A><E><N><R><K><S><S><I><I><I><R><M><R><D><A><V><L><F><E><K>
May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.<BOP>
Q02325
Q8NHM4
TRY6_HUMAN
Trypsinogen C
Homo
<M><N><P><L><L><I><L><A><F><V><G><A><A><V><A><V><P><F><D><D><D><D><K><I><V><G><G><Y><T><C><E><E><N><S><V><P><Y><Q><V><S><L><N><S><G><S><H><F><C><G><G><S><L><I><S><E><Q><W><V><V><S><A><G><H><C><Y><K><P><H><I><Q><V><R><L><G><E><H><N><I><E><V><L><E><G><N><E><Q><F><I><N><A><A><K><I><I><R><H><P><K><Y><N><R><I><I><L><N><N><D><I><M><L><I><K><L><S><T><P><A><V><I><N><A><H><V><S><T><I><S><L><P><T><A><P><P><A><A><G><T><E><C><L><I><S><G><W><G><N><T><L><S><S><G><A><D><Y><P><D><E><L><Q><C><L><D><A><P><V><L><T><Q><A><K><C><K><A><S><Y><P><L><K><I><T><S><N><M><F><C><V><G><F><L><E><G><G><K><D><S><C><Q><G><D><S><G><G><P><V><V><C><N><G><Q><L><Q><G><I><V><S><W><G><Y><G><C><A><Q><K><R><R><P><G><V><Y><T><K><V><Y><N><Y><V><D><W><I><K><D><T><I><A><A><N><S>
May regulate cell migration.<BOP>
Q8NHM4
Q8WV16
DCAF4_HUMAN
WD repeat-containing protein 21A
Homo
<M><N><K><S><R><W><Q><S><R><R><R><H><G><R><R><S><H><Q><Q><N><P><W><F><R><L><R><D><S><E><D><R><S><D><S><R><A><A><Q><P><A><H><D><S><G><H><G><D><D><E><S><P><S><T><S><S><G><T><A><G><T><S><S><V><P><E><L><P><G><F><Y><F><D><P><E><K><K><R><Y><F><R><L><L><P><G><H><N><N><C><N><P><L><T><K><E><S><I><R><Q><K><E><M><E><S><K><R><L><R><L><L><Q><E><E><D><R><R><K><K><I><A><R><M><G><F><N><A><S><S><M><L><R><K><S><Q><L><G><F><L><N><V><T><N><Y><C><H><L><A><H><E><L><R><L><S><C><M><E><R><K><K><V><Q><I><R><S><M><D><P><S><A><L><A><S><D><R><F><N><L><I><L><A><D><T><N><S><D><R><L><F><T><V><N><D><V><K><V><G><G><S><K><Y><G><I><I><N><L><Q><S><L><K><T><P><T><L><K><V><F><M><H><E><N><L><Y><F><T><N><R><K><V><N><S><V><C><W><A><S><L><N><H><L><D><S><H><I><L><L><C><L><M><G><L><A><E><T><P><G><C><A><T><L><L><P><A><S><L><F><V><N><S><H><P><G><I><D><R><P><G><M><L><C><S><F><R><I><P><G><A><W><S><C><A><W><S><L><N><I><Q><A><N><N><C><F><S><T><G><L><S><R><R><V><L><L><T><N><V><V><T><G><H><R><Q><S><F><G><T><N><S><D><V><L><A><Q><Q><F><A><L><M><A><P><L><L><F><N><G><C><R><S><G><E><I><F><A><I><D><L><R><C><G><N><Q><G><K><G><W><K><A><T><R><L><F><H><D><S><A><V><T><S><V><R><I><L><Q><D><E><Q><Y><L><M><A><S><D><M><A><G><K><I><K><L><W><D><L><R><T><T><K><C><V><R><Q><Y><E><G><H><V><N><E><Y><A><Y><L><P><L><H><V><H><E><E><E><G><I><L><V><A><V><G><Q><D><C><Y><T><R><I><W><S><L><H><D><A><R><L><L><R><T><I><P><S><P><Y><P><A><S><K><A><D><I><P><S><V><A><F><S><S><R><L><G><G><S><R><G><A><P><G><L><L><M><A><V><G><Q><D><L><Y><C><Y><S><Y><S>
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.<BOP>
Q8WV16
Q0VFZ6
CF210_HUMAN
Coiled-coil domain-containing protein 173
Homo
<M><D><T><S><S><E><M><L><V><R><F><G><R><R><C><G><R><A><K><E><S><T><E><I><R><N><S><E><E><D><Q><V><L><Y><L><P><L><L><P><S><K><V><D><L><Q><Q><V><T><I><I><P><H><D><E><W><K><R><I><Q><D><S><L><D><R><L><T><R><E><A><A><C><L><R><A><E><R><K><A><K><K><E><M><H><L><R><S><Q><E><V><V><K><H><W><T><N><T><Y><A><G><M><K><E><Q><K><L><E><A><K><K><K><R><D><E><E><I><E><A><E><R><Q><I><L><D><L><E><E><E><I><Y><K><Q><G><K><R><K><K><A><I><E><N><A><K><Q><Y><Q><F><Y><Q><T><E><R><V><K><N><F><H><S><G><L><L><L><S><R><V><M><K><E><R><D><A><Q><I><E><F><R><K><S><K><I><K><S><D><K><K><W><E><E><Q><L><K><L><N><I><E><K><A><F><K><E><E><Q><E><K><A><E><K><R><H><R><E><R><V><A><L><A><K><D><H><L><K><Q><I><K><E><H><E><E><E><E><E><R><R><K><K><Y><E><E><K><D><A><E><E><I><K><R><Q><N><A><L><Y><E><I><E><M><R><K><K><L><E><K><K><R><E><E><M><H><E><S><R><R><R><F><L><E><H><M><Q><D><K><H><I><I><K><A><V><E><Q><Q><Q><Q><E><E><E><D><E><K><M><R><K><F><I><K><A><K><K><R><L><I><Q><M><G><K><E><K><E><A><E><T><H><R><L><M><E><K><R><R><E><R><I><H><N><F><L><S><E><L><L><K><E><K><L><D><N><E><D><M><I><I><A><R><D><I><A><E><A><E><A><E><W><E><K><R><E><R><E><K><D><E><K><N><K><A><E><L><K><T><I><A><E><Y><R><A><I><V><M><K><N><K><E><E><E><E><R><Q><R><K><I><E><A><K><E><Q><L><L><A><V><M><K><A><D><Q><I><F><W><E><H><E><K><E><K><K><C><K><A><D><K><E><H><Q><E><V><Q><D><A><H><I><Q><Q><M><A><K><N><K><F><N><A><K><Q><A><K><Q><A><E><L><D><Y><C><R><L><T><E><A><L><V><A><E><K><E><K><E><F><Q><D><Y><A><R><E><V><I><E><L><E><S><E><T><T><N><K><Y><I><Y><P><L><V><K><A><V><Q><E><G><P><G><G><G><R><G><P><V><F><V><D><R><G><G><L><R><P><S><Y><Q><A><N><D><V><T><G><V><Q><L><P><F><Y><N><S><Q><G><P><K><Y><N><F><Q><K><S><K><R><R><L><G><F><T><W>
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.<BOP>
Q0VFZ6
A6NDL7
MT21E_HUMAN
Putative methyltransferase-like protein 21E pseudogene
Homo
<M><I><H><F><N><L><L><E><T><Q><L><T><P><L><A><S><F><Q><E><I><M><K><K><T><S><I><Y><H><L><P><S><F><H><Y><L><M><D><S><E><A><Q><E><D><T><R><E><A><Y><D><D><K><Q><V><V><T><E><I><M><A><R><C><F><I><P><T><L><I><T><T><T><S><W><E><S><F><H><F><I><G><H><E><I><R><I><T><E><A><M><D><C><Y><G><A><V><V><W><P><S><A><L><V><L><C><Y><F><L><E><T><N><A><K><Q><Y><N><M><V><D><K><N><V><I><E><I><G><A><G><T><G><L><V><S><I><V><A><S><L><L><G><A><H><V><T><A><T><D><L><P><E><L><L><G><N><L><Q><Y><N><I><S><R><N><T><K><M><K><S><K><H><L><P><Q><V><K><E><L><S><W><G><V><A><L><D><T><N><F><P><R><S><S><N><N><F><D><Y><I><L><A><A><D><V><V><Y><A><H><P><F><L><E><E><L><L><I><T><F><D><H><L><C><K><E><T><T><I><I><L><W><A><M><K><F><R><L><E><K><E><N><K><F><V><D><R><F><K><E><L><F><D><L><E><E><I><S><S><F><P><S><L><N><I><K><L><Y><K><A><V><K><K><N><R><R><S><V>
Protein-lysine methyltransferase.<BOP>
A6NDL7
P32856
STX2_HUMAN
Epimorphin
Homo
<M><R><D><R><L><P><D><L><T><A><C><R><K><N><D><D><G><D><T><V><V><V><V><E><K><D><H><F><M><D><D><F><F><H><Q><V><E><E><I><R><N><S><I><D><K><I><T><Q><Y><V><E><E><V><K><K><N><H><S><I><I><L><S><A><P><N><P><E><G><K><I><K><E><E><L><E><D><L><N><K><E><I><K><K><T><A><N><K><I><R><A><K><L><K><A><I><E><Q><S><F><D><Q><D><E><S><G><N><R><T><S><V><D><L><R><I><R><R><T><Q><H><S><V><L><S><R><K><F><V><E><A><M><A><E><Y><N><E><A><Q><T><L><F><R><E><R><S><K><G><R><I><Q><R><Q><L><E><I><T><G><R><T><T><T><D><D><E><L><E><E><M><L><E><S><G><K><P><S><I><F><T><S><D><I><I><S><D><S><Q><I><T><R><Q><A><L><N><E><I><E><S><R><H><K><D><I><M><K><L><E><T><S><I><R><E><L><H><E><M><F><M><D><M><A><M><F><V><E><T><Q><G><E><M><I><N><N><I><E><R><N><V><M><N><A><T><D><Y><V><E><H><A><K><E><E><T><K><K><A><I><K><Y><Q><S><K><A><R><R><K><K><W><I><I><I><A><V><S><V><V><L><V><A><I><I><A><L><I><I><G><L><S><V><G><K>
Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.<BOP>
P32856
Q99895
CTRC_HUMAN
Caldecrin
Homo
<M><L><G><I><T><V><L><A><A><L><L><A><C><A><S><S><C><G><V><P><S><F><P><P><N><L><S><A><R><V><V><G><G><E><D><A><R><P><H><S><W><P><W><Q><I><S><L><Q><Y><L><K><N><D><T><W><R><H><T><C><G><G><T><L><I><A><S><N><F><V><L><T><A><A><H><C><I><S><N><T><R><T><Y><R><V><A><V><G><K><N><N><L><E><V><E><D><E><E><G><S><L><F><V><G><V><D><T><I><H><V><H><K><R><W><N><A><L><L><L><R><N><D><I><A><L><I><K><L><A><E><H><V><E><L><S><D><T><I><Q><V><A><C><L><P><E><K><D><S><L><L><P><K><D><Y><P><C><Y><V><T><G><W><G><R><L><W><T><N><G><P><I><A><D><K><L><Q><Q><G><L><Q><P><V><V><D><H><A><T><C><S><R><I><D><W><W><G><F><R><V><K><K><T><M><V><C><A><G><G><D><G><V><I><S><A><C><N><G><D><S><G><G><P><L><N><C><Q><L><E><N><G><S><W><E><V><F><G><I><V><S><F><G><S><R><R><G><C><N><T><R><K><K><P><V><V><Y><T><R><V><S><A><Y><I><D><W><I><N><E><K><M><Q><L>
Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.<BOP>
Q99895
P50238
CRIP1_HUMAN
Cysteine-rich intestinal protein
Homo
<M><P><K><C><P><K><C><N><K><E><V><Y><F><A><E><R><V><T><S><L><G><K><D><W><H><R><P><C><L><K><C><E><K><C><G><K><T><L><T><S><G><G><H><A><E><H><E><G><K><P><Y><C><N><H><P><C><Y><A><A><M><F><G><P><K><G><F><G><R><G><G><A><E><S><H><T><F><K>
Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.<BOP>
P50238
Q96LQ0
PPR36_HUMAN
Protein phosphatase 1 regulatory subunit 36
Homo
<M><Y><R><V><P><E><F><Y><A><R><R><K><R><L><G><G><Q><T><P><Y><L><M><D><Q><L><G><L><R><L><G><M><W><Y><W><K><D><E><T><R><T><L><E><F><R><R><F><A><A><E><D><S><V><Q><W><L><L><K><H><H><P><H><F><T><P><A><A><E><V><K><E><K><G><K><K><G><K><A><V><H><F><A><E><T><D><G><P><A><S><D><R><L><T><D><K><R><L><A><A><K><D><D><K><S><A><K><A><V><E><K><R><G><Q><Q><G><T><I><T><L><D><D><V><K><F><V><T><L><L><L><L><Q><D><T><E><M><Q><R><I><C><S><F><T><T><F><M><R><N><K><N><L><D><N><F><L><M><A><L><L><Y><Y><L><S><H><Y><L><E><K><N><S><L><E><K><K><P><K><S><Y><M><V><G><L><V><E><K><K><E><M><E><L><V><L><S><E><L><E><A><A><Q><R><Y><L><A><Q><K><Y><C><I><L><V><L><G><L><A><V><P><D><K><H><H><M><C><C><G><K><E><K><I><S><D><T><Q><K><D><W><K><F><F><E><S><F><Y><T><F><C><T><Y><V><A><W><I><V><F><R><R><Q><H><L><T><E><I><E><E><E><V><G><R><L><F><R><T><N><M><F><N><I><P><R><R><R><R><E><D><E><E><S><G><G><E><K><K><R><M><T><F><V><Q><F><R><R><M><M><A><K><R><P><A><I><K><K><A><I><N><M><R><S><P><V><M><S><T><L><L><P><S><L><R><E><K><A><Q><N><V><F><E><K><K><Y><H><Q><V><D><V><R><F><P><A><E><M><Q><K><H><V><G><T><L><D><S><V><P><M><P><V><V><G><I><L><G><E><P><R><C><L><F><N><P><H><T><L><H><P><L><D><P><E><E><N><T><K><S><F><G><R><Y><P><S><L><M><E><N><N><N><M><R><I><Q><D><T><L><D><L><V><M><K><T><L><S><S><H><T><S><C><P><K>
Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.<BOP>
Q96LQ0
Q8IV61
GRP3_HUMAN
Guanine nucleotide exchange factor for Rap1
Homo
<M><G><S><S><G><L><G><K><A><A><T><L><D><E><L><L><C><T><C><I><E><M><F><D><D><N><G><E><L><D><N><S><Y><L><P><R><I><V><L><L><M><H><R><W><Y><L><S><S><T><E><L><A><E><K><L><L><C><M><Y><R><N><A><T><G><E><S><C><N><E><F><R><L><K><I><C><Y><F><M><R><Y><W><I><L><K><F><P><A><E><F><N><L><D><L><G><L><I><R><M><T><E><E><F><R><E><V><A><S><Q><L><G><Y><E><K><H><V><S><L><I><D><I><S><S><I><P><S><Y><D><W><M><R><R><V><T><Q><R><K><K><V><S><K><K><G><K><A><C><L><L><F><D><H><L><E><P><I><E><L><A><E><H><L><T><F><L><E><H><K><S><F><R><R><I><S><F><T><D><Y><Q><S><Y><V><I><H><G><C><L><E><N><N><P><T><L><E><R><S><I><A><L><F><N><G><I><S><K><W><V><Q><L><M><V><L><S><K><P><T><P><Q><Q><R><A><E><V><I><T><K><F><I><N><V><A><K><K><L><L><Q><L><K><N><F><N><T><L><M><A><V><V><G><G><L><S><H><S><S><I><S><R><L><K><E><T><H><S><H><L><S><S><E><V><T><K><N><W><N><E><M><T><E><L><V><S><S><N><G><N><Y><C><N><Y><R><K><A><F><A><D><C><D><G><F><K><I><P><I><L><G><V><H><L><K><D><L><I><A><V><H><V><I><F><P><D><W><T><E><E><N><K><V><N><I><V><K><M><H><Q><L><S><V><T><L><S><E><L><V><S><L><Q><N><A><S><H><H><L><E><P><N><M><D><L><I><N><L><L><T><L><S><L><D><L><Y><H><T><E><D><D><I><Y><K><L><S><L><V><L><E><P><R><N><S><K><S><Q><P><T><S><P><T><T><P><N><K><P><V><V><P><L><E><W><A><L><G><V><M><P><K><P><D><P><T><V><I><N><K><H><I><R><K><L><V><E><S><V><F><R><N><Y><D><H><D><H><D><G><Y><I><S><Q><E><D><F><E><S><I><A><A><N><F><P><F><L><D><S><F><C><V><L><D><K><D><Q><D><G><L><I><S><K><D><E><M><M><A><Y><F><L><R><A><K><S><Q><L><H><C><K><M><G><P><G><F><I><H><N><F><Q><E><M><T><Y><L><K><P><T><F><C><E><H><C><A><G><F><L><W><G><I><I><K><Q><G><Y><K><C><K><D><C><G><A><N><C><H><K><Q><C><K><D><L><L><V><L><A><C><R><R><F><A><R><A><P><S><L><S><S><G><H><G><S><L><P><G><S><P><S><L><P><P><A><Q><D><E><V><F><E><F><P><G><V><T><A><G><H><R><D><L><D><S><R><A><I><T><L><V><T><G><S><S><R><K><I><S><V><R><L><Q><R><A><T><T><S><Q><A><T><Q><T><E><P><V><W><S><E><A><G><W><G><D><S><G><S><H><T><F><P><K><M><K><S><K><F><H><D><K><A><A><K><D><K><G><F><A><K><W><E><N><E><K><P><R><V><H><A><G><V><D><V><V><D><R><G><T><E><F><E><L><D><Q><D><E><G><E><E><T><R><Q><D><G><E><D><G>
Guanine nucleotide exchange factor (GEF) for Ras and Rap1.<BOP>
Q8IV61
Q8WTR8
NET5_HUMAN
Netrin-1-like protein
Homo
<M><P><V><T><F><A><L><L><L><L><L><G><Q><A><T><A><D><P><C><Y><D><P><Q><G><R><P><Q><F><C><L><P><P><V><T><Q><L><A><A><V><A><A><S><C><P><Q><A><C><A><L><S><P><G><N><H><L><G><A><R><E><T><C><N><G><S><L><T><L><A><L><G><G><P><F><L><L><T><S><V><S><L><R><F><C><T><P><G><P><P><A><L><I><L><S><A><A><W><A><S><G><G><P><W><R><L><L><W><H><R><P><A><W><P><G><A><L><G><G><P><E><R><V><T><F><H><S><T><P><G><P><K><A><T><V><A><A><S><H><L><R><V><E><F><G><G><Q><A><G><L><A><A><A><G><L><R><G><R><C><Q><C><H><G><H><A><A><R><C><A><A><R><A><R><P><P><R><C><H><C><R><H><H><T><T><G><P><G><C><E><S><C><R><P><S><H><R><D><W><P><W><R><P><A><T><P><R><H><P><H><P><C><L><P><C><S><C><N><Q><H><A><R><R><C><R><F><N><S><E><L><F><R><L><S><G><G><R><S><G><G><V><C><E><R><C><R><H><H><T><A><G><R><H><C><H><Y><C><Q><P><G><F><W><R><D><P><S><Q><P><I><F><S><R><R><A><C><R><A><C><Q><C><H><P><I><G><A><T><G><G><T><C><N><Q><T><S><G><Q><C><T><C><K><L><G><V><T><G><L><T><C><N><R><C><G><P><G><Y><Q><Q><S><R><S><P><R><M><P><C><Q><R><I><P><E><A><T><T><T><L><A><T><T><P><G><A><Y><S><S><D><P><Q><C><Q><N><Y><C><N><M><S><D><T><R><V><H><M><S><L><R><R><Y><C><Q><Q><D><H><V><L><R><A><Q><V><L><A><S><E><A><A><G><P><A><W><Q><R><L><A><V><R><V><L><A><V><Y><K><Q><R><A><Q><P><V><R><R><G><D><Q><D><A><W><V><P><R><A><D><L><T><C><G><C><L><R><L><Q><P><G><T><D><Y><L><L><L><G><S><A><V><G><D><P><D><P><T><R><L><I><L><D><R><H><G><L><A><L><P><W><R><P><R><W><A><R><P><L><K><R><L><Q><Q><E><E><R><A><G><G><C><R><G><V><R><A><P><T><P><S><P><R><P><E><H>
Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube.<BOP>
Q8WTR8
P49888
ST1E1_HUMAN
Sulfotransferase, estrogen-preferring
Homo
<M><N><S><E><L><D><Y><Y><E><K><F><E><E><V><H><G><I><L><M><Y><K><D><F><V><K><Y><W><D><N><V><E><A><F><Q><A><R><P><D><D><L><V><I><A><T><Y><P><K><S><G><T><T><W><V><S><E><I><V><Y><M><I><Y><K><E><G><D><V><E><K><C><K><E><D><V><I><F><N><R><I><P><F><L><E><C><R><K><E><N><L><M><N><G><V><K><Q><L><D><E><M><N><S><P><R><I><V><K><T><H><L><P><P><E><L><L><P><A><S><F><W><E><K><D><C><K><I><I><Y><L><C><R><N><A><K><D><V><A><V><S><F><Y><Y><F><F><L><M><V><A><G><H><P><N><P><G><S><F><P><E><F><V><E><K><F><M><Q><G><Q><V><P><Y><G><S><W><Y><K><H><V><K><S><W><W><E><K><G><K><S><P><R><V><L><F><L><F><Y><E><D><L><K><E><D><I><R><K><E><V><I><K><L><I><H><F><L><E><R><K><P><S><E><E><L><V><D><R><I><I><H><H><T><S><F><Q><E><M><K><N><N><P><S><T><N><Y><T><T><L><P><D><E><I><M><N><Q><K><L><S><P><F><M><R><K><G><I><T><G><D><W><K><N><H><F><T><V><A><L><N><E><K><F><D><K><H><Y><E><Q><Q><M><K><E><S><T><L><K><F><R><T><E><I>
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone . Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency . Does not sulfonate cortisol, testosterone and dopamine . May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.<BOP>
P49888
Q9Y2U9
KLDC2_HUMAN
Host cell factor-like protein 1
Homo
<M><A><D><G><N><E><D><L><R><A><D><D><L><P><G><P><A><F><E><S><Y><E><S><M><E><L><A><C><P><A><E><R><S><G><H><V><A><V><S><D><G><R><H><M><F><V><W><G><G><Y><K><S><N><Q><V><R><G><L><Y><D><F><Y><L><P><R><E><E><L><W><I><Y><N><M><E><T><G><R><W><K><K><I><N><T><E><G><D><V><P><P><S><M><S><G><S><C><A><V><C><V><D><R><V><L><Y><L><F><G><G><H><H><S><R><G><N><T><N><K><F><Y><M><L><D><S><R><S><T><D><R><V><L><Q><W><E><R><I><D><C><Q><G><I><P><P><S><S><K><D><K><L><G><V><W><V><Y><K><N><K><L><I><F><F><G><G><Y><G><Y><L><P><E><D><K><V><L><G><T><F><E><F><D><E><T><S><F><W><N><S><S><H><P><R><G><W><N><D><H><V><H><I><L><D><T><E><T><F><T><W><S><Q><P><I><T><T><G><K><A><P><S><P><R><A><A><H><A><C><A><T><V><G><N><R><G><F><V><F><G><G><R><Y><R><D><A><R><M><N><D><L><H><Y><L><N><L><D><T><W><E><W><N><E><L><I><P><Q><G><I><C><P><V><G><R><S><W><H><S><L><T><P><V><S><S><D><H><L><F><L><F><G><G><F><T><T><D><K><Q><P><L><S><D><A><W><T><Y><C><I><S><K><N><E><W><I><Q><F><N><H><P><Y><T><E><K><P><R><L><W><H><T><A><C><A><S><D><E><G><E><V><I><V><F><G><G><C><A><N><N><L><L><V><H><H><R><A><A><H><S><N><E><I><L><I><F><S><V><Q><P><K><S><L><V><R><L><S><L><E><A><V><I><C><F><K><E><M><L><A><N><S><W><N><C><L><P><K><H><L><L><H><S><V><N><Q><R><F><G><S><N><N><T><S><G><S>
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation . The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine . The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation . May also act as an indirect repressor of CREB3
Q9Y2U9
Q8N109
KI2LA_HUMAN
Killer cell immunoglobulin-like receptor 2DL5A
Homo
<M><S><L><M><V><I><S><M><A><C><V><G><F><F><L><L><Q><G><A><W><T><H><E><G><G><Q><D><K><P><L><L><S><A><W><P><S><A><V><V><P><R><G><G><H><V><T><L><L><C><R><S><R><L><G><F><T><I><F><S><L><Y><K><E><D><G><V><P><V><P><E><L><Y><N><K><I><F><W><K><S><I><L><M><G><P><V><T><P><A><H><A><G><T><Y><R><C><R><G><S><H><P><R><S><P><I><E><W><S><A><P><S><N><P><L><V><I><V><V><T><G><L><F><G><K><P><S><L><S><A><Q><P><G><P><T><V><R><T><G><E><N><V><T><L><S><C><S><S><R><S><S><F><D><M><Y><H><L><S><R><E><G><R><A><H><E><P><R><L><P><A><V><P><S><V><N><G><T><F><Q><A><D><F><P><L><G><P><A><T><H><G><G><T><Y><T><C><F><G><S><L><H><D><S><P><Y><E><W><S><D><P><S><D><P><L><L><V><S><V><T><G><N><S><S><S><S><S><S><S><P><T><E><P><S><S><K><T><G><I><R><R><H><L><H><I><L><I><G><T><S><V><A><I><I><L><F><I><I><L><F><F><F><L><L><H><C><C><C><S><N><K><K><N><A><A><V><M><D><Q><E><P><A><G><D><R><T><V><N><R><E><D><S><D><D><Q><D><P><Q><E><V><T><Y><A><Q><L><D><H><C><V><F><T><Q><T><K><I><T><S><P><S><Q><R><P><K><T><P><P><T><D><T><T><M><Y><M><E><L><P><N><A><K><P><R><S><L><S><P><A><H><K><H><H><S><Q><A><L><R><G><S><S><R><E><T><T><A><L><S><Q><N><R><V><A><S><S><H><V><P><A><A><G><I>
Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.<BOP>
Q8N109
Q15048
LRC14_HUMAN
Leucine-rich repeat-containing protein 14
Homo
<M><H><T><L><V><F><L><S><T><R><Q><V><L><Q><C><Q><P><A><A><C><Q><A><L><P><L><L><P><R><E><L><F><P><L><L><F><K><V><A><F><M><D><K><K><T><V><V><L><R><E><L><V><H><T><W><P><F><P><L><L><S><F><Q><Q><L><L><Q><E><C><A><H><C><S><R><A><L><L><Q><E><R><P><S><T><E><S><M><Q><A><V><I><L><G><L><T><A><R><L><H><T><S><E><P><G><A><S><T><Q><P><L><C><R><K><H><A><L><R><V><L><D><M><T><G><L><L><D><D><G><V><E><Q><D><P><G><T><M><S><M><W><D><C><T><A><A><V><A><R><T><C><I><A><Q><Q><Q><G><G><A><A><E><P><G><P><A><P><I><P><V><E><V><R><V><D><L><R><V><N><R><A><S><Y><A><F><L><R><E><A><L><R><S><S><V><G><S><P><L><R><L><C><C><R><D><L><R><A><E><D><L><P><M><R><N><T><V><A><L><L><Q><L><L><D><A><G><C><L><R><R><V><D><L><R><F><N><N><L><G><L><R><G><L><S><V><I><I><P><H><V><A><R><F><Q><H><L><A><S><L><R><L><H><Y><V><H><G><D><S><R><Q><P><S><V><D><G><E><D><N><F><R><Y><F><L><A><Q><M><G><R><F><T><C><L><R><E><L><S><M><G><S><S><L><L><S><G><R><L><D><Q><L><L><S><T><L><Q><S><P><L><E><S><L><E><L><A><F><C><A><L><L><P><E><D><L><R><F><L><A><R><S><P><H><A><A><H><L><K><K><L><D><L><S><G><N><D><L><S><G><S><Q><L><A><P><F><Q><G><L><L><Q><A><S><A><A><T><L><L><H><L><E><L><T><E><C><Q><L><A><D><T><Q><L><L><A><T><L><P><I><L><T><Q><C><A><S><L><R><Y><L><G><L><Y><G><N><P><L><S><M><A><G><L><K><E><L><L><R><D><S><V><A><Q><A><E><L><R><T><V><V><H><P><F><P><V><D><C><Y><E><G><L><P><W><P><P><P><A><S><V><L><L><E><A><S><I><N><E><E><K><F><A><R><V><E><A><E><L><H><Q><L><L><L><A><S><G><R><A><H><V><L><W><T><T><D><I><Y><G><R><L><A><A><D><Y><F><S><L>
Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.<BOP>
Q15048
P01701
LV151_HUMAN
Ig lambda chain V-I region NIG-64
Homo
<M><T><C><S><P><L><L><L><T><L><L><I><H><C><T><G><S><W><A><Q><S><V><L><T><Q><P><P><S><V><S><A><A><P><G><Q><K><V><T><I><S><C><S><G><S><S><S><N><I><G><N><N><Y><V><S><W><Y><Q><Q><L><P><G><T><A><P><K><L><L><I><Y><D><N><N><K><R><P><S><G><I><P><D><R><F><S><G><S><K><S><G><T><S><A><T><L><G><I><T><G><L><Q><T><G><D><E><A><D><Y><Y><C><G><T><W><D><S><S><L><S><A>
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P01701
P35270
SPRE_HUMAN
Sepiapterin reductase
Homo
<M><E><G><G><L><G><R><A><V><C><L><L><T><G><A><S><R><G><F><G><R><T><L><A><P><L><L><A><S><L><L><S><P><G><S><V><L><V><L><S><A><R><N><D><E><A><L><R><Q><L><E><A><E><L><G><A><E><R><S><G><L><R><V><V><R><V><P><A><D><L><G><A><E><A><G><L><Q><Q><L><L><G><A><L><R><E><L><P><R><P><K><G><L><Q><R><L><L><L><I><N><N><A><G><S><L><G><D><V><S><K><G><F><V><D><L><S><D><S><T><Q><V><N><N><Y><W><A><L><N><L><T><S><M><L><C><L><T><S><S><V><L><K><A><F><P><D><S><P><G><L><N><R><T><V><V><N><I><S><S><L><C><A><L><Q><P><F><K><G><W><A><L><Y><C><A><G><K><A><A><R><D><M><L><F><Q><V><L><A><L><E><E><P><N><V><R><V><L><N><Y><A><P><G><P><L><D><T><D><M><Q><Q><L><A><R><E><T><S><V><D><P><D><M><R><K><G><L><Q><E><L><K><A><K><G><K><L><V><D><C><K><V><S><A><Q><K><L><L><S><L><L><E><K><D><E><F><K><S><G><A><H><V><D><F><Y><D><K>
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.<BOP>
P35270
Q99640
PMYT1_HUMAN
Myt1 kinase
Homo
<M><L><E><R><P><P><A><L><A><M><P><M><P><T><E><G><T><P><P><P><L><S><G><T><P><I><P><V><P><A><Y><F><R><H><A><E><P><G><F><S><L><K><R><P><R><G><L><S><R><S><L><P><P><P><P><P><A><K><G><S><I><P><I><S><R><L><F><P><P><R><T><P><G><W><H><Q><L><Q><P><R><R><V><S><F><R><G><E><A><S><E><T><L><Q><S><P><G><Y><D><P><S><R><P><E><S><F><F><Q><Q><S><F><Q><R><L><S><R><L><G><H><G><S><Y><G><E><V><F><K><V><R><S><K><E><D><G><R><L><Y><A><V><K><R><S><M><S><P><F><R><G><P><K><D><R><A><R><K><L><A><E><V><G><S><H><E><K><V><G><Q><H><P><C><C><V><R><L><E><Q><A><W><E><E><G><G><I><L><Y><L><Q><T><E><L><C><G><P><S><L><Q><Q><H><C><E><A><W><G><A><S><L><P><E><A><Q><V><W><G><Y><L><R><D><T><L><L><A><L><A><H><L><H><S><Q><G><L><V><H><L><D><V><K><P><A><N><I><F><L><G><P><R><G><R><C><K><L><G><D><F><G><L><L><V><E><L><G><T><A><G><A><G><E><V><Q><E><G><D><P><R><Y><M><A><P><E><L><L><Q><G><S><Y><G><T><A><A><D><V><F><S><L><G><L><T><I><L><E><V><A><C><N><M><E><L><P><H><G><G><E><G><W><Q><Q><L><R><Q><G><Y><L><P><P><E><F><T><A><G><L><S><S><E><L><R><S><V><L><V><M><M><L><E><P><D><P><K><L><R><A><T><A><E><A><L><L><A><L><P><V><L><R><Q><P><R><A><W><G><V><L><W><C><M><A><A><E><A><L><S><R><G><W><A><L><W><Q><A><L><L><A><L><L><C><W><L><W><H><G><L><A><H><P><A><S><W><L><Q><P><L><G><P><P><A><T><P><P><G><S><P><P><C><S><L><L><L><D><S><S><L><S><S><N><W><D><D><D><S><L><G><P><S><L><S><P><E><A><V><L><A><R><T><V><G><S><T><S><T><P><R><S><R><C><T><P><R><D><A><L><D><L><S><D><I><N><S><E><P><P><R><G><S><F><P><S><F><E><P><R><N><L><L><S><L><F><E><D><T><L><D><P><T>
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.<BOP>
Q99640
Q9BYG5
PAR6B_HUMAN
Partitioning defective 6 homolog beta
Homo
<M><N><R><S><H><R><H><G><A><G><S><G><C><L><G><T><M><E><V><K><S><K><F><G><A><E><F><R><R><F><S><L><E><R><S><K><P><G><K><F><E><E><F><Y><G><L><L><Q><H><V><H><K><I><P><N><V><D><V><L><V><G><Y><A><D><I><H><G><D><L><L><P><I><N><N><D><D><N><Y><H><K><A><V><S><T><A><N><P><L><L><R><I><F><I><Q><K><K><E><E><A><D><Y><S><A><F><G><T><D><T><L><I><K><K><K><N><V><L><T><N><V><L><R><P><D><N><H><R><K><K><P><H><I><V><I><S><M><P><Q><D><F><R><P><V><S><S><I><I><D><V><D><I><L><P><E><T><H><R><R><V><R><L><Y><K><Y><G><T><E><K><P><L><G><F><Y><I><R><D><G><S><S><V><R><V><T><P><H><G><L><E><K><V><P><G><I><F><I><S><R><L><V><P><G><G><L><A><Q><S><T><G><L><L><A><V><N><D><E><V><L><E><V><N><G><I><E><V><S><G><K><S><L><D><Q><V><T><D><M><M><I><A><N><S><R><N><L><I><I><T><V><R><P><A><N><Q><R><N><N><V><V><R><N><S><R><T><S><G><S><S><G><Q><S><T><D><N><S><L><L><G><Y><P><Q><Q><I><E><P><S><F><E><P><E><D><E><D><S><E><E><D><D><I><I><I><E><D><N><G><V><P><Q><Q><I><P><K><A><V><P><N><T><E><S><L><E><S><L><T><Q><I><E><L><S><F><E><S><G><Q><N><G><F><I><P><S><N><E><V><S><L><A><A><I><A><S><S><S><N><T><E><F><E><T><H><A><P><D><Q><K><L><L><E><E><D><G><T><I><I><T><L>
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.<BOP>
Q9BYG5
Q9Y6R0
NUMBL_HUMAN
Numb-related protein
Homo
<M><S><R><S><A><A><A><S><G><G><P><R><R><P><E><R><H><L><P><P><A><P><C><G><A><P><G><P><P><E><T><C><R><T><E><P><D><G><A><G><T><M><N><K><L><R><Q><S><L><R><R><R><K><P><A><Y><V><P><E><A><S><R><P><H><Q><W><Q><A><D><E><D><A><V><R><K><G><T><C><S><F><P><V><R><Y><L><G><H><V><E><V><E><E><S><R><G><M><H><V><C><E><D><A><V><K><K><L><K><A><M><G><R><K><S><V><K><S><V><L><W><V><S><A><D><G><L><R><V><V><D><D><K><T><K><D><L><L><V><D><Q><T><I><E><K><V><S><F><C><A><P><D><R><N><L><D><K><A><F><S><Y><I><C><R><D><G><T><T><R><R><W><I><C><H><C><F><L><A><L><K><D><S><G><E><R><L><S><H><A><V><G><C><A><F><A><A><C><L><E><R><K><Q><R><R><E><K><E><C><G><V><T><A><A><F><D><A><S><R><T><S><F><A><R><E><G><S><F><R><L><S><G><G><G><R><P><A><E><R><E><A><P><D><K><K><K><A><E><A><A><A><A><P><T><V><A><P><G><P><A><Q><P><G><H><V><S><P><T><P><A><T><T><S><P><G><E><K><G><E><A><G><T><P><V><A><A><G><T><T><A><A><A><I><P><R><R><H><A><P><L><E><Q><L><V><R><Q><G><S><F><R><G><F><P><A><L><S><Q><K><N><S><P><F><K><R><Q><L><S><L><R><L><N><E><L><P><S><T><L><Q><R><R><T><D><F><Q><V><K><G><T><V><P><E><M><E><P><P><G><A><G><D><S><D><S><I><N><A><L><C><T><Q><I><S><S><S><F><A><S><A><G><A><P><A><P><G><P><P><P><A><T><T><G><T><S><A><W><G><E><P><S><V><P><P><A><A><A><F><Q><P><G><H><K><R><T><P><S><E><A><E><R><W><L><E><E><V><S><Q><V><A><K><A><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><A><A><S><V><A><P><V><P><T><M><P><P><A><L><Q><P><F><P><A><P><V><G><P><F><D><A><A><P><A><Q><V><A><V><F><L><P><P><P><H><M><Q><P><P><F><V><P><A><Y><P><G><L><G><Y><P><P><M><P><R><V><P><V><V><G><I><T><P><S><Q><M><V><A><N><A><F><C><S><A><A><Q><L><Q><P><Q><P><A><T><L><L><G><K><A><G><A><F><P><P><P><A><I><P><S><A><P><G><S><Q><A><R><P><R><P><N><G><A><P><W><P><P><E><P><A><P><A><P><A><P><E><L><D><P><F><E><A><Q><W><A><A><L><E><G><K><A><T><V><E><K><P><S><N><P><F><S><G><D><L><Q><K><T><F><E><I><E><L>
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.<BOP>
Q9Y6R0
Q3LXA3
TKFC_HUMAN
FMN cyclase
Homo
<M><T><S><K><K><L><V><N><S><V><A><G><C><A><D><D><A><L><A><G><L><V><A><C><N><P><N><L><Q><L><L><Q><G><H><R><V><A><L><R><S><D><L><D><S><L><K><G><R><V><A><L><L><S><G><G><G><S><G><H><E><P><A><H><A><G><F><I><G><K><G><M><L><T><G><V><I><A><G><A><V><F><T><S><P><A><V><G><S><I><L><A><A><I><R><A><V><A><Q><A><G><T><V><G><T><L><L><I><V><K><N><Y><T><G><D><R><L><N><F><G><L><A><R><E><Q><A><R><A><E><G><I><P><V><E><M><V><V><I><G><D><D><S><A><F><T><V><L><K><K><A><G><R><R><G><L><C><G><T><V><L><I><H><K><V><A><G><A><L><A><E><A><G><V><G><L><E><E><I><A><K><Q><V><N><V><V><A><K><A><M><G><T><L><G><V><S><L><S><S><C><S><V><P><G><S><K><P><T><F><E><L><S><A><D><E><V><E><L><G><L><G><I><H><G><E><A><G><V><R><R><I><K><M><A><T><A><D><E><I><V><K><L><M><L><D><H><M><T><N><T><T><N><A><S><H><V><P><V><Q><P><G><S><S><V><V><M><M><V><N><N><L><G><G><L><S><F><L><E><L><G><I><I><A><D><A><T><V><R><S><L><E><G><R><G><V><K><I><A><R><A><L><V><G><T><F><M><S><A><L><E><M><P><G><I><S><L><T><L><L><L><V><D><E><P><L><L><K><L><I><D><A><E><T><T><A><A><A><W><P><N><V><A><A><V><S><I><T><G><R><K><R><S><R><V><A><P><A><E><P><Q><E><A><P><D><S><T><A><A><G><G><S><A><S><K><R><M><A><L><V><L><E><R><V><C><S><T><L><L><G><L><E><E><H><L><N><A><L><D><R><A><A><G><D><G><D><C><G><T><T><H><S><R><A><A><R><A><I><Q><E><W><L><K><E><G><P><P><P><A><S><P><A><Q><L><L><S><K><L><S><V><L><L><L><E><K><M><G><G><S><S><G><A><L><Y><G><L><F><L><T><A><A><A><Q><P><L><K><A><K><T><S><L><P><A><W><S><A><A><M><D><A><G><L><E><A><M><Q><K><Y><G><K><A><A><P><G><D><R><T><M><L><D><S><L><W><A><A><G><Q><E><L><Q><A><W><K><S><P><G><A><D><L><L><Q><V><L><T><K><A><V><K><S><A><E><A><A><A><E><A><T><K><N><M><E><A><G><A><G><R><A><S><Y><I><S><S><A><R><L><E><Q><P><D><P><G><A><V><A><A><A><A><I><L><R><A><I><L><E><V><L><Q><S>
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response .<BOP>
Q3LXA3
P0C7M4
RHF2B_HUMAN
Rhox homeobox family member 2B
Homo
<M><E><P><P><D><Q><C><S><Q><Y><M><T><S><L><L><S><P><A><V><D><D><E><K><E><L><Q><D><M><N><A><M><V><L><S><L><T><E><E><V><K><E><E><E><E><D><A><Q><P><E><P><E><Q><G><T><A><A><G><E><K><L><K><S><A><G><A><Q><G><G><E><E><K><D><G><G><G><E><E><K><D><G><G><G><A><G><V><P><G><H><L><W><E><G><N><L><E><G><T><S><G><S><D><G><N><V><E><D><S><D><Q><S><E><K><E><P><G><Q><Q><Y><S><R><P><Q><G><A><V><G><G><L><E><P><G><N><A><Q><Q><P><N><V><H><A><F><T><P><L><Q><L><Q><E><L><E><C><I><F><Q><R><E><Q><F><P><S><E><F><L><R><R><R><L><A><R><S><M><N><V><T><E><L><A><V><Q><I><W><F><E><N><R><R><A><K><W><R><R><H><Q><R><A><L><M><A><R><N><M><L><P><F><M><A><V><G><Q><P><V><M><V><T><A><A><E><A><I><T><A><P><L><F><I><S><G><M><R><D><D><Y><F><W><D><H><S><H><S><S><S><L><C><F><P><M><P><P><F><P><P><P><S><L><P><L><P><L><M><L><L><P><P><M><P><P><A><G><Q><A><E><F><G><P><F><P><F><V><I><V><P><S><F><T><F><P><N><V>
Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.<BOP>
P0C7M4
Q9NZT1
CALL5_HUMAN
Calmodulin-like skin protein
Homo
<M><A><G><E><L><T><P><E><E><E><A><Q><Y><K><K><A><F><S><A><V><D><T><D><G><N><G><T><I><N><A><Q><E><L><G><A><A><L><K><A><T><G><K><N><L><S><E><A><Q><L><R><K><L><I><S><E><V><D><S><D><G><D><G><E><I><S><F><Q><E><F><L><T><A><A><K><K><A><R><A><G><L><E><D><L><Q><V><A><F><R><A><F><D><Q><D><G><D><G><H><I><T><V><D><E><L><R><R><A><M><A><G><L><G><Q><P><L><P><Q><E><E><L><D><A><M><I><R><E><A><D><V><D><Q><D><G><R><V><N><Y><E><E><F><A><R><M><L><A><Q><E>
Binds calcium. May be involved in terminal differentiation of keratinocytes.<BOP>
Q9NZT1
Q99714
HCD2_HUMAN
Type II HADH
Homo
<M><A><A><A><C><R><S><V><K><G><L><V><A><V><I><T><G><G><A><S><G><L><G><L><A><T><A><E><R><L><V><G><Q><G><A><S><A><V><L><L><D><L><P><N><S><G><G><E><A><Q><A><K><K><L><G><N><N><C><V><F><A><P><A><D><V><T><S><E><K><D><V><Q><T><A><L><A><L><A><K><G><K><F><G><R><V><D><V><A><V><N><C><A><G><I><A><V><A><S><K><T><Y><N><L><K><K><G><Q><T><H><T><L><E><D><F><Q><R><V><L><D><V><N><L><M><G><T><F><N><V><I><R><L><V><A><G><E><M><G><Q><N><E><P><D><Q><G><G><Q><R><G><V><I><I><N><T><A><S><V><A><A><F><E><G><Q><V><G><Q><A><A><Y><S><A><S><K><G><G><I><V><G><M><T><L><P><I><A><R><D><L><A><P><I><G><I><R><V><M><T><I><A><P><G><L><F><G><T><P><L><L><T><S><L><P><E><K><V><C><N><F><L><A><S><Q><V><P><F><P><S><R><L><G><D><P><A><E><Y><A><H><L><V><Q><A><I><I><E><N><P><F><L><N><G><E><V><I><R><L><D><G><A><I><R><M><Q><P>
In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends . Together with TRMT10C/MRPP1, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity . The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic subunit . The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyl
Q99714
Q5MJ68
SPDYC_HUMAN
Rapid inducer of G2/M progression in oocytes C
Homo
<M><L><W><A><I><P><E><L><G><S><P><C><P><I><S><I><S><Y><E><M><S><D><S><Q><D><P><T><T><S><P><V><V><T><T><Q><V><E><L><G><G><C><S><R><Q><G><G><G><N><G><F><L><R><F><R><Q><H><Q><E><V><Q><A><F><L><S><L><L><E><D><S><F><V><Q><E><F><L><S><K><D><P><C><F><Q><I><S><D><K><Y><L><L><A><M><V><L><V><Y><F><Q><R><A><H><L><K><L><S><E><Y><T><H><S><S><L><F><L><A><L><Y><L><A><N><D><M><E><E><D><L><E><G><P><K><C><E><I><F><P><W><A><L><G><K><D><W><C><L><R><V><G><K><F><L><H><Q><R><D><K><L><W><A><R><M><G><F><R><A><V><V><S><R><Q><C><C><E><E><V><M><A><K><E><P><F><H><W><A><W><T><R><D><R><R><P><H><H><G><G><V><Q><R><V><C><P><Q><V><P><V><R><L><P><R><G><P><G><L><S><P><P><H><C><S><P><C><G><L><P><Q><H><C><S><S><H><L><L><K><P><V><S><S><K><C><P><S><L><T><S><E><C><H><R><P><P><S><Q><N><Y><L><S><R><V><K><N><A><W><G><G><D><F><L><I><V><L><P><P><Q><M><Q><L><E><P><G><T><Y><S><L><R><I><F><P><K><P><P><A><R><P><G><H>
Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase.<BOP>
Q5MJ68
Q9H777
RNZ1_HUMAN
tRNase Z 1
Homo
<M><S><M><D><V><T><F><L><G><T><G><A><A><Y><P><S><P><T><R><G><A><S><A><V><V><L><R><C><E><G><E><C><W><L><F><D><C><G><E><G><T><Q><T><Q><L><M><K><S><Q><L><K><A><G><R><I><T><K><I><F><I><T><H><L><H><G><D><H><F><F><G><L><P><G><L><L><C><T><I><S><L><Q><S><G><S><M><V><S><K><Q><P><I><E><I><Y><G><P><V><G><L><R><D><F><I><W><R><T><M><E><L><S><H><T><E><L><V><F><H><Y><V><V><H><E><L><V><P><T><A><D><Q><C><P><A><E><E><L><K><E><F><A><H><V><N><R><A><D><S><P><P><K><E><E><Q><G><R><T><I><L><L><D><S><E><E><N><S><Y><L><L><F><D><D><E><Q><F><V><V><K><A><F><R><L><F><H><R><I><P><S><F><G><F><S><V><V><E><K><K><R><P><G><K><L><N><A><Q><K><L><K><D><L><G><V><P><P><G><P><A><Y><G><K><L><K><N><G><I><S><V><V><L><E><N><G><V><T><I><S><P><Q><D><V><L><K><K><P><I><V><G><R><K><I><C><I><L><G><D><C><S><G><V><V><G><D><G><G><V><K><L><C><F><E><A><D><L><L><I><H><E><A><T><L><D><D><A><Q><M><D><K><A><K><E><H><G><H><S><T><P><Q><M><A><A><T><F><A><K><L><C><R><A><K><R><L><V><L><T><H><F><S><Q><R><Y><K><P><V><A><L><A><R><E><G><E><T><D><G><I><A><E><L><K><K><Q><A><E><S><V><L><D><L><Q><E><V><T><L><A><E><D><F><M><V><I><S><I><P><I><K><K>
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.<BOP>
Q9H777
A0A0K2S4Q6
CD3CH_HUMAN
CD300 antigen-like family member H
Homo
<M><T><Q><R><A><G><A><A><M><L><P><S><A><L><L><L><L><C><V><P><G><C><L><T><V><S><G><P><S><T><V><M><G><A><V><G><E><S><L><S><V><Q><C><R><Y><E><E><K><Y><K><T><F><N><K><Y><W><C><R><Q><P><C><L><P><I><W><H><E><M><V><E><T><G><G><S><E><G><V><V><R><S><D><Q><V><I><I><T><D><H><P><G><D><L><T><F><T><V><T><L><E><N><L><T><A><D><D><A><G><K><Y><R><C><G><I><A><T><I><L><Q><E><D><G><L><S><G><F><L><P><D><P><F><F><Q><V><Q><V><L><V><S><S><A><S><S><T><E><N><S><V><K><T><P><A><S><P><T><R><P><S><Q><C><Q><G><S><L><P><S><S><T><C><F><L><L><L><P><L><L><K><V><P><L><L><L><S><I><L><G><A><I><L><W><V><N><R><P><W><R><T><P><W><T><E><S>
May play an important role in innate immunity by mediating a signal for the production of a neutrophil chemoattractant.<BOP>
A0A0K2S4Q6
Q9UHP9
SMPX_HUMAN
Stretch-responsive skeletal muscle protein
Homo
<M><N><M><S><K><Q><P><V><S><N><V><R><A><I><Q><A><N><I><N><I><P><M><G><A><F><R><P><G><A><G><Q><P><P><R><R><K><E><C><T><P><E><V><E><E><G><V><P><P><T><S><D><E><E><K><K><P><I><P><G><A><K><K><L><P><G><P><A><V><N><L><S><E><I><Q><N><I><K><S><E><L><K><Y><V><P><K><A><E><Q>
Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.<BOP>
Q9UHP9
Q53G59
KLH12_HUMAN
DKIR homolog
Homo
<M><G><G><I><M><A><P><K><D><I><M><T><N><T><H><A><K><S><I><L><N><S><M><N><S><L><R><K><S><N><T><L><C><D><V><T><L><R><V><E><Q><K><D><F><P><A><H><R><I><V><L><A><A><C><S><D><Y><F><C><A><M><F><T><S><E><L><S><E><K><G><K><P><Y><V><D><I><Q><G><L><T><A><S><T><M><E><I><L><L><D><F><V><Y><T><E><T><V><H><V><T><V><E><N><V><Q><E><L><L><P><A><A><C><L><L><Q><L><K><G><V><K><Q><A><C><C><E><F><L><E><S><Q><L><D><P><S><N><C><L><G><I><R><D><F><A><E><T><H><N><C><V><D><L><M><Q><A><A><E><V><F><S><Q><K><H><F><P><E><V><V><Q><H><E><E><F><I><L><L><S><Q><G><E><V><E><K><L><I><K><C><D><E><I><Q><V><D><S><E><E><P><V><F><E><A><V><I><N><W><V><K><H><A><K><K><E><R><E><E><S><L><P><N><L><L><Q><Y><V><R><M><P><L><L><T><P><R><Y><I><T><D><V><I><D><A><E><P><F><I><R><C><S><L><Q><C><R><D><L><V><D><E><A><K><K><F><H><L><R><P><E><L><R><S><Q><M><Q><G><P><R><T><R><A><R><L><G><A><N><E><V><L><L><V><V><G><G><F><G><S><Q><Q><S><P><I><D><V><V><E><K><Y><D><P><K><T><Q><E><W><S><F><L><P><S><I><T><R><K><R><R><Y><V><A><S><V><S><L><H><D><R><I><Y><V><I><G><G><Y><D><G><R><S><R><L><S><S><V><E><C><L><D><Y><T><A><D><E><D><G><V><W><Y><S><V><A><P><M><N><V><R><R><G><L><A><G><A><T><T><L><G><D><M><I><Y><V><S><G><G><F><D><G><S><R><R><H><T><S><M><E><R><Y><D><P><N><I><D><Q><W><S><M><L><G><D><M><Q><T><A><R><E><G><A><G><L><V><V><A><S><G><V><I><Y><C><L><G><G><Y><D><G><L><N><I><L><N><S><V><E><K><Y><D><P><H><T><G><H><W><T><N><V><T><P><M><A><T><K><R><S><G><A><G><V><A><L><L><N><D><H><I><Y><V><V><G><G><F><D><G><T><A><H><L><S><S><V><E><A><Y><N><I><R><T><D><S><W><T><T><V><T><S><M><T><T><P><R><C><Y><V><G><A><T><V><L><R><G><R><L><Y><A><I><A><G><Y><D><G><N><S><L><L><S><S><I><E><C><Y><D><P><I><I><D><S><W><E><V><V><T><S><M><G><T><Q><R><C><D><A><G><V><C><V><L><R><E><K>
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport . The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) . The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export . As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis
Q53G59
Q9Y5L4
TIM13_HUMAN
Mitochondrial import inner membrane translocase subunit Tim13
Homo
<M><E><G><G><F><G><S><D><F><G><G><S><G><S><G><K><L><D><P><G><L><I><M><E><Q><V><K><V><Q><I><A><V><A><N><A><Q><E><L><L><Q><R><M><T><D><K><C><F><R><K><C><I><G><K><P><G><G><S><L><D><N><S><E><Q><K><C><I><A><M><C><M><D><R><Y><M><D><A><W><N><T><V><S><R><A><Y><N><S><R><L><Q><R><E><R><A><N><M>
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins.<BOP>
Q9Y5L4
O43422
P52K_HUMAN
THAP domain-containing protein 12
Homo
<M><P><N><F><C><A><A><P><N><C><T><R><K><S><T><Q><S><D><L><A><F><F><R><F><P><R><D><P><A><R><C><Q><K><W><V><E><N><C><R><R><A><D><L><E><D><K><T><P><D><Q><L><N><K><H><Y><R><L><C><A><K><H><F><E><T><S><M><I><C><R><T><S><P><Y><R><T><V><L><R><D><N><A><I><P><T><I><F><D><L><T><S><H><L><N><N><P><H><S><R><H><R><K><R><I><K><E><L><S><E><D><E><I><R><T><L><K><Q><K><K><I><D><E><T><S><E><Q><E><Q><K><H><K><E><T><N><N><S><N><A><Q><N><P><S><E><E><E><G><E><G><Q><D><E><D><I><L><P><L><T><L><E><E><K><E><N><K><E><Y><L><K><S><L><F><E><I><L><I><L><M><G><K><Q><N><I><P><L><D><G><H><E><A><D><E><I><P><E><G><L><F><T><P><D><N><F><Q><A><L><L><E><C><R><I><N><S><G><E><E><V><L><R><K><R><F><E><T><T><A><V><N><T><L><F><C><S><K><T><Q><Q><R><Q><M><L><E><I><C><E><S><C><I><R><E><E><T><L><R><E><V><R><D><S><H><F><F><S><I><I><T><D><D><V><V><D><I><A><G><E><E><H><L><P><V><L><V><R><F><V><D><E><S><H><N><L><R><E><E><F><I><G><F><L><P><Y><E><A><D><A><E><I><L><A><V><K><F><H><T><M><I><T><E><K><W><G><L><N><M><E><Y><C><R><G><Q><A><Y><I><V><S><S><G><F><S><S><K><M><K><V><V><A><S><R><L><L><E><K><Y><P><Q><A><I><Y><T><L><C><S><S><C><A><L><N><M><W><L><A><K><S><V><P><V><M><G><V><S><V><A><L><G><T><I><E><E><V><C><S><F><F><H><R><S><P><Q><L><L><L><E><L><D><N><V><I><S><V><L><F><Q><N><S><K><E><R><G><K><E><L><K><E><I><C><H><S><Q><W><T><G><R><H><D><A><F><E><I><L><V><E><L><L><Q><A><L><V><L><C><L><D><G><I><N><S><D><T><N><I><R><W><N><N><Y><I><A><G><R><A><F><V><L><C><S><A><V><S><D><F><D><F><I><V><T><I><V><V><L><K><N><V><L><S><F><T><R><A><F><G><K><N><L><Q><G><Q><T><S><D><V><F><F><A><A><G><S><L><T><A><V><L><H><S><L><N><E><V><M><E><N><I><E><V><Y><H><E><F><W><F><E><E><A><T><N><L><A><T><K><L><D><I><Q><M><K><L><P><G><K><F><R><R><A><H><Q><G><N><L><E><S><Q><L><T><S><E><S><Y><Y><K><E><T><L><S><V><P><T><V><E><H><I><I><Q><E><L><K><D><I><F><S><E><Q><H><L><K><A><L><K><C><L><S><L><V><P><S><V><M><G><Q><L><K><F><N><T><S><E><E><H><H><A><D><M><Y><R><S><D><L><P><N><P><D><T><L><S><A><E><L><H><C><W><R><I><K><W><K><H><R><G><K><D><I><E><L><P><S><T><I><Y><E><A><L><H><L><P><D><I><K><F><F><P><N><V><Y><A><L><L><K><V><L><C><I><L><P><V><M><K><V><E><N><E><R><Y><E><N><G><R><K><R><L><K><A><Y><L><R><N><T><L><T><D><Q><R><S><S><N><L><A><L><L><N><I><N><F><D><I><K><H><D><L><D><L><M><V><D><T><Y><I><K><L><Y><T><S><K><S><E><L><P><T><D><N><S><E><T><V><E><N><T>
Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.<BOP>
O43422
Q96MF7
NSE2_HUMAN
Non-structural maintenance of chromosomes element 2 homolog
Homo
<M><P><G><R><S><S><S><N><S><G><S><T><G><F><I><S><F><S><G><V><E><S><A><L><S><S><L><K><N><F><Q><A><C><I><N><S><G><M><D><T><A><S><S><V><A><L><D><L><V><E><S><Q><T><E><V><S><S><E><Y><S><M><D><K><A><M><V><E><F><A><T><L><D><R><Q><L><N><H><Y><V><K><A><V><Q><S><T><I><N><H><V><K><E><E><R><P><E><K><I><P><D><L><K><L><L><V><E><K><K><F><L><A><L><Q><S><K><N><S><D><A><D><F><Q><N><N><E><K><F><V><Q><F><K><Q><Q><L><K><E><L><K><K><Q><C><G><L><Q><A><D><R><E><A><D><G><T><E><G><V><D><E><D><I><I><V><T><Q><S><Q><T><N><F><T><C><P><I><T><K><E><E><M><K><K><P><V><K><N><K><V><C><G><H><T><Y><E><E><D><A><I><V><R><M><I><E><S><R><Q><K><R><K><K><K><A><Y><C><P><Q><I><G><C><S><H><T><D><I><R><K><S><D><L><I><Q><D><E><A><L><R><R><A><I><E><N><H><N><K><K><R><H><R><H><S><E>
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination . Is not be required for the stability of the complex . The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks . The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) . Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2 . Required for recruitment of telomeres to PML nuclear bodies . SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines
Q96MF7
Q8IUD6
RN135_HUMAN
RING-type E3 ubiquitin transferase RNF135
Homo
<M><A><G><L><G><L><G><S><A><V><P><V><W><L><A><E><D><D><L><G><C><I><I><C><Q><G><L><L><D><W><P><A><T><L><P><C><G><H><S><F><C><R><H><C><L><E><A><L><W><G><A><R><D><A><R><R><W><A><C><P><T><C><R><Q><G><A><A><Q><Q><P><H><L><R><K><N><T><L><L><Q><D><L><A><D><K><Y><R><R><A><A><R><E><I><Q><A><G><S><D><P><A><H><C><P><C><P><G><S><S><S><L><S><S><A><A><A><R><P><R><R><R><P><E><L><Q><R><V><A><V><E><K><S><I><T><E><V><A><Q><E><L><T><E><L><V><E><H><L><V><D><I><V><R><S><L><Q><N><Q><R><P><L><S><E><S><G><P><D><N><E><L><S><I><L><G><K><A><F><S><S><G><V><D><L><S><M><A><S><P><K><L><V><T><S><D><T><A><A><G><K><I><R><D><I><L><H><D><L><E><E><I><Q><E><K><L><Q><E><S><V><T><W><K><E><A><P><E><A><Q><M><Q><G><E><L><L><E><A><P><S><S><S><S><C><P><L><P><D><Q><S><H><P><A><L><R><R><A><S><R><F><A><Q><W><A><I><H><P><T><F><N><L><K><S><L><S><C><S><L><E><V><S><K><D><S><R><T><V><T><V><S><H><R><P><Q><P><Y><R><W><S><C><E><R><F><S><T><S><Q><V><L><C><S><Q><A><L><S><S><G><K><H><Y><W><E><V><D><T><R><N><C><S><H><W><A><V><G><V><A><S><W><E><M><S><R><D><Q><V><L><G><R><T><M><D><S><C><C><V><E><W><K><G><T><S><Q><L><S><A><W><H><M><V><K><E><T><V><L><G><S><D><R><P><G><V><V><G><I><W><L><N><L><E><E><G><K><L><A><F><Y><S><V><D><N><Q><E><K><L><L><Y><E><C><T><I><S><A><S><S><P><L><Y><P><A><F><W><L><Y><G><L><H><P><G><N><Y><L><I><I><K><Q><V><K><V>
E2-dependent E3 ubiquitin-protein ligase that functions as a RIG-I/DDX58 coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response . Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway . Through a ubiquitin-independent parallel mechanism, which consists in bridging RIG-I/DDX58 filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway . This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (Probable). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway .<BOP>
Q8IUD6
P24158
PRTN3_HUMAN
Wegener autoantigen
Homo
<M><A><H><R><P><P><S><P><A><L><A><S><V><L><L><A><L><L><L><S><G><A><A><R><A><A><E><I><V><G><G><H><E><A><Q><P><H><S><R><P><Y><M><A><S><L><Q><M><R><G><N><P><G><S><H><F><C><G><G><T><L><I><H><P><S><F><V><L><T><A><A><H><C><L><R><D><I><P><Q><R><L><V><N><V><V><L><G><A><H><N><V><R><T><Q><E><P><T><Q><Q><H><F><S><V><A><Q><V><F><L><N><N><Y><D><A><E><N><K><L><N><D><V><L><L><I><Q><L><S><S><P><A><N><L><S><A><S><V><A><T><V><Q><L><P><Q><Q><D><Q><P><V><P><H><G><T><Q><C><L><A><M><G><W><G><R><V><G><A><H><D><P><P><A><Q><V><L><Q><E><L><N><V><T><V><V><T><F><F><C><R><P><H><N><I><C><T><F><V><P><R><R><K><A><G><I><C><F><G><D><S><G><G><P><L><I><C><D><G><I><I><Q><G><I><D><S><F><V><I><W><G><C><A><T><R><L><F><P><D><F><F><T><R><V><A><L><Y><V><D><W><I><R><S><T><L><R><R><V><E><A><K><G><R><P>
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) . By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration . May play a role in neutrophil transendothelial migration, probably when associated with CD177 .<BOP>
P24158
Q9Y259
CHKB_HUMAN
choline/ethanolamine kinase beta
Homo
<M><A><A><E><A><T><A><V><A><G><S><G><A><V><G><G><C><L><A><K><D><G><L><Q><Q><S><K><C><P><D><T><T><P><K><R><R><R><A><S><S><L><S><R><D><A><E><R><R><A><Y><Q><W><C><R><E><Y><L><G><G><A><W><R><R><V><Q><P><E><E><L><R><V><Y><P><V><S><G><G><L><S><N><L><L><F><R><C><S><L><P><D><H><L><P><S><V><G><E><E><P><R><E><V><L><L><R><L><Y><G><A><I><L><Q><G><V><D><S><L><V><L><E><S><V><M><F><A><I><L><A><E><R><S><L><G><P><Q><L><Y><G><V><F><P><E><G><R><L><E><Q><Y><I><P><S><R><P><L><K><T><Q><E><L><R><E><P><V><L><S><A><A><I><A><T><K><M><A><Q><F><H><G><M><E><M><P><F><T><K><E><P><H><W><L><F><G><T><M><E><R><Y><L><K><Q><I><Q><D><L><P><P><T><G><L><P><E><M><N><L><L><E><M><Y><S><L><K><D><E><M><G><N><L><R><K><L><L><E><S><T><P><S><P><V><V><F><C><H><N><D><I><Q><E><G><N><I><L><L><L><S><E><P><E><N><A><D><S><L><M><L><V><D><F><E><Y><S><S><Y><N><Y><R><G><F><D><I><G><N><H><F><C><E><W><V><Y><D><Y><T><H><E><E><W><P><F><Y><K><A><R><P><T><D><Y><P><T><Q><E><Q><Q><L><H><F><I><R><H><Y><L><A><E><A><K><K><G><E><T><L><S><Q><E><E><Q><R><K><L><E><E><D><L><L><V><E><V><S><R><Y><A><L><A><S><H><F><F><W><G><L><W><S><I><L><Q><A><S><M><S><T><I><E><F><G><Y><L><D><Y><A><Q><S><R><F><Q><F><Y><F><Q><Q><K><G><Q><L><T><S><V><H><S><S><S>
Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis.<BOP>
Q9Y259
Q86WX3
AROS_HUMAN
40S ribosomal protein S19-binding protein 1
Homo
<M><S><A><A><L><L><R><R><G><L><E><L><L><A><A><S><E><A><P><R><D><P><P><G><Q><A><K><P><R><G><A><P><V><K><R><P><R><K><T><K><A><I><Q><A><Q><K><L><R><N><S><A><K><G><K><V><P><K><S><A><L><D><E><Y><R><K><R><E><C><R><D><H><L><R><V><N><L><K><F><L><T><R><T><R><S><T><V><A><E><S><V><S><Q><Q><I><L><R><Q><N><R><G><R><K><A><C><D><R><P><V><A><K><T><K><K><K><K><A><E><G><T><V><F><T><E><E><D><F><Q><K><F><Q><Q><E><Y><F><G><S>
Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.<BOP>
Q86WX3
Q9NS18
GLRX2_HUMAN
Glutaredoxin-2, mitochondrial
Homo
<M><I><W><R><R><A><A><L><A><G><T><R><L><V><W><S><R><S><G><S><A><G><W><L><D><R><A><A><G><A><A><G><A><A><A><A><A><A><S><G><M><E><S><N><T><S><S><S><L><E><N><L><A><T><A><P><V><N><Q><I><Q><E><T><I><S><D><N><C><V><V><I><F><S><K><T><S><C><S><Y><C><T><M><A><K><K><L><F><H><D><M><N><V><N><Y><K><V><V><E><L><D><L><L><E><Y><G><N><Q><F><Q><D><A><L><Y><K><M><T><G><E><R><T><V><P><R><I><F><V><N><G><T><F><I><G><G><A><T><D><T><H><R><L><H><K><E><G><K><L><L><P><L><V><H><Q><C><Y><L><K><K><S><K><R><K><E><F><Q>
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.<BOP>
Q9NS18
O00186
STXB3_HUMAN
Protein unc-18 homolog C
Homo
<M><A><P><P><V><A><E><R><G><L><K><S><V><V><W><Q><K><I><K><A><T><V><F><D><D><C><K><K><E><G><E><W><K><I><M><L><L><D><E><F><T><T><K><L><L><A><S><C><C><K><M><T><D><L><L><E><E><G><I><T><V><V><E><N><I><Y><K><N><R><E><P><V><R><Q><M><K><A><L><Y><F><I><T><P><T><S><K><S><V><D><C><F><L><H><D><F><A><S><K><S><E><N><K><Y><K><A><A><Y><I><Y><F><T><D><F><C><P><D><N><L><F><N><K><I><K><A><S><C><S><K><S><I><R><R><C><K><E><I><N><I><S><F><I><P><H><E><S><Q><V><Y><T><L><D><V><P><D><A><F><Y><Y><C><Y><S><P><D><P><G><N><A><K><G><K><D><A><I><M><E><T><M><A><D><Q><I><V><T><V><C><A><T><L><D><E><N><P><G><V><R><Y><K><S><K><P><L><D><N><A><S><K><L><A><Q><L><V><E><K><K><L><E><D><Y><Y><K><I><D><E><K><S><L><I><K><G><K><T><H><S><Q><L><L><I><I><D><R><G><F><D><P><V><S><T><V><L><H><E><L><T><F><Q><A><M><A><Y><D><L><L><P><I><E><N><D><T><Y><K><Y><K><T><D><G><K><E><K><E><A><I><L><E><E><E><D><D><L><W><V><R><I><R><H><R><H><I><A><V><V><L><E><E><I><P><K><L><M><K><E><I><S><S><T><K><K><A><T><E><G><K><T><S><L><S><A><L><T><Q><L><M><K><K><M><P><H><F><R><K><Q><I><T><K><Q><V><V><H><L><N><L><A><E><D><C><M><N><K><F><K><L><N><I><E><K><L><C><K><T><E><Q><D><L><A><L><G><T><D><A><E><G><Q><K><V><K><D><S><M><R><V><L><L><P><V><L><L><N><K><N><H><D><N><C><D><K><I><R><A><I><L><L><Y><I><F><S><I><N><G><T><T><E><E><N><L><D><R><L><I><Q><N><V><K><I><E><N><E><S><D><M><I><R><N><W><S><Y><L><G><V><P><I><V><P><Q><S><Q><Q><G><K><P><L><R><K><D><R><S><A><E><E><T><F><Q><L><S><R><W><T><P><F><I><K><D><I><M><E><D><A><I><D><N><R><L><D><S><K><E><W><P><Y><C><S><Q><C><P><A><V><W><N><G><S><G><A><V><S><A><R><Q><K><P><R><A><N><Y><L><E><D><R><K><N><G><S><K><L><I><V><F><V><I><G><G><I><T><Y><S><E><V><R><C><A><Y><E><V><S><Q><A><H><K><S><C><E><V><I><I><G><S><T><H><V><L><T><P><K><K><L><L><D><D><I><K><M><L><N><K><P><K><D><K><V><S><L><I><K><D><E>
Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.<BOP>
O00186
Q6ZV65
FA47E_HUMAN
Protein FAM47E
Homo
<M><A><D><R><R><R><R><L><R><P><G><T><L><A><P><V><R><E><G><V><N><C><R><S><R><C><F><T><K><H><K><N><G><L><K><F><P><T><S><L><H><S><R><Q><L><V><F><P><R><K><G><L><D><D><F><R><K><G><C><P><P><C><T><G><L><V><T><Q><V><P><V><E><G><F><L><P><Q><I><Y><H><R><A><P><Q><L><A><P><K><K><R><Q><I><K><L><L><K><E><A><D><V><L><S><K><L><S><P><A><Q><Q><A><R><K><A><F><L><E><D><V><E><A><H><L><T><P><H><P><L><A><L><Y><L><N><L><E><E><A><M><P><I><E><L><L><S><K><V><L><E><V><L><D><P><D><R><K><L><E><D><T><W><A><Y><C><Q><D><T><R><K><G><M><K><E><P><T><K><L><L><K><K><H><S><T><Q><V><Y><L><G><P><S><K><K><T><S><V><S><N><A><G><Q><W><L><Y><E><E><K><P><H><K><M><D><L><L><H><E><N><G><P><R><P><G><L><H><E><N><G><I><S><D><I><D><E><E><F><I><L><K><Q><F><D><I><D><Y><E><T><K><P><S><H><D><A><L><H><T><M><K><L><N><Q><V><P><L><E><L><K><R><S><V><G><L><S><K><L><Q><E><T><E><F><F><Q><K><L><G><Y><E><R><K><L><Q><K><P><Q><N><P><Y><K><P><K><W><V><K><M><R><Y><G><A><W><Y><L><N><P><K><L><W><K><K><Q><R><V><D><E><P><L><V><D><P><E><V><S><H><K><A><Q><E><E><N><F><K><K><E><L><Q><E><Q><E><E><L><L><A><D><L><H><G><T><V><A><F><K><D><F><I><L><S><R><G><Y><R><T><P><R><F><L><E><N><M><Y><I><G><K><E><C><K><R><A><C><N><K><T><P><I><K><R><T><Q><A>
Promotes histone methylation by localizing the arginine methyltransferase PRMT5 to chromatin.<BOP>
Q6ZV65
Q9UHF4
I20RA_HUMAN
ZcytoR7
Homo
<M><R><A><P><G><R><P><A><L><R><P><L><P><L><P><P><L><L><L><L><L><L><A><A><P><W><G><R><A><V><P><C><V><S><G><G><L><P><K><P><A><N><I><T><F><L><S><I><N><M><K><N><V><L><Q><W><T><P><P><E><G><L><Q><G><V><K><V><T><Y><T><V><Q><Y><F><I><Y><G><Q><K><K><W><L><N><K><S><E><C><R><N><I><N><R><T><Y><C><D><L><S><A><E><T><S><D><Y><E><H><Q><Y><Y><A><K><V><K><A><I><W><G><T><K><C><S><K><W><A><E><S><G><R><F><Y><P><F><L><E><T><Q><I><G><P><P><E><V><A><L><T><T><D><E><K><S><I><S><V><V><L><T><A><P><E><K><W><K><R><N><P><E><D><L><P><V><S><M><Q><Q><I><Y><S><N><L><K><Y><N><V><S><V><L><N><T><K><S><N><R><T><W><S><Q><C><V><T><N><H><T><L><V><L><T><W><L><E><P><N><T><L><Y><C><V><H><V><E><S><F><V><P><G><P><P><R><R><A><Q><P><S><E><K><Q><C><A><R><T><L><K><D><Q><S><S><E><F><K><A><K><I><I><F><W><Y><V><L><P><V><S><I><T><V><F><L><F><S><V><M><G><Y><S><I><Y><R><Y><I><H><V><G><K><E><K><H><P><A><N><L><I><L><I><Y><G><N><E><F><D><K><R><F><F><V><P><A><E><K><I><V><I><N><F><I><T><L><N><I><S><D><D><S><K><I><S><H><Q><D><M><S><L><L><G><K><S><S><D><V><S><S><L><N><D><P><Q><P><S><G><N><L><R><P><P><Q><E><E><E><E><V><K><H><L><G><Y><A><S><H><L><M><E><I><F><C><D><S><E><E><N><T><E><G><T><S><L><T><Q><Q><E><S><L><S><R><T><I><P><P><D><K><T><V><I><E><Y><E><Y><D><V><R><T><T><D><I><C><A><G><P><E><E><Q><E><L><S><L><Q><E><E><V><S><T><Q><G><T><L><L><E><S><Q><A><A><L><A><V><L><G><P><Q><T><L><Q><Y><S><Y><T><P><Q><L><Q><D><L><D><P><L><A><Q><E><H><T><D><S><E><E><G><P><E><E><E><P><S><T><T><L><V><D><W><D><P><Q><T><G><R><L><C><I><P><S><L><S><S><F><D><Q><D><S><E><G><C><E><P><S><E><G><D><G><L><G><E><E><G><L><L><S><R><L><Y><E><E><P><A><P><D><R><P><P><G><E><N><E><T><Y><L><M><Q><F><M><E><E><W><G><L><Y><V><Q><M><E><N>
The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.<BOP>
Q9UHF4
P55008
AIF1_HUMAN
Protein G1
Homo
<M><S><Q><T><R><D><L><Q><G><G><K><A><F><G><L><L><K><A><Q><Q><E><E><R><L><D><E><I><N><K><Q><F><L><D><D><P><K><Y><S><S><D><E><D><L><P><S><K><L><E><G><F><K><E><K><Y><M><E><F><D><L><N><G><N><G><D><I><D><I><M><S><L><K><R><M><L><E><K><L><G><V><P><K><T><H><L><E><L><K><K><L><I><G><E><V><S><S><G><S><G><E><T><F><S><Y><P><D><F><L><R><M><M><L><G><K><R><S><A><I><L><K><M><I><L><M><Y><E><E><K><A><R><E><K><E><K><P><T><G><P><P><A><K><K><A><I><S><E><L><P>
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.<BOP>
P55008
Q9H6F2
TM38A_HUMAN
Transmembrane protein 38A
Homo
<M><E><L><L><S><A><L><S><L><G><E><L><A><L><S><F><S><R><V><P><L><F><P><V><F><D><L><S><Y><F><I><V><S><I><L><Y><L><K><Y><E><P><G><A><V><E><L><S><R><R><H><P><I><A><S><W><L><C><A><M><L><H><C><F><G><S><Y><I><L><A><D><L><L><L><G><E><P><L><I><D><Y><F><S><N><N><S><S><I><L><L><A><S><A><V><W><Y><L><I><F><F><C><P><L><D><L><F><Y><K><C><V><C><F><L><P><V><K><L><I><F><V><A><M><K><E><V><V><R><V><R><K><I><A><V><G><I><H><H><A><H><H><H><Y><H><H><G><W><F><V><M><I><A><T><G><W><V><K><G><S><G><V><A><L><M><S><N><F><E><Q><L><L><R><G><V><W><K><P><E><T><N><E><I><L><H><M><S><F><P><T><K><A><S><L><Y><G><A><I><L><F><T><L><Q><Q><T><R><W><L><P><V><S><K><A><S><L><I><F><I><F><T><L><F><M><V><S><C><K><V><F><L><T><A><T><H><S><H><S><S><P><F><D><A><L><E><G><Y><I><C><P><V><L><F><G><S><A><C><G><G><D><H><H><H><D><N><H><G><G><S><H><S><G><G><G><P><G><A><Q><H><S><A><M><P><A><K><S><K><E><E><L><S><E><G><S><R><K><K><K><A><K><K><A><D>
Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.<BOP>
Q9H6F2
O43741
AAKB2_HUMAN
5'-AMP-activated protein kinase subunit beta-2
Homo
<M><G><N><T><T><S><D><R><V><S><G><E><R><H><G><A><K><A><A><R><S><E><G><A><G><G><H><A><P><G><K><E><H><K><I><M><V><G><S><T><D><D><P><S><V><F><S><L><P><D><S><K><L><P><G><D><K><E><F><V><S><W><Q><Q><D><L><E><D><S><V><K><P><T><Q><Q><A><R><P><T><V><I><R><W><S><E><G><G><K><E><V><F><I><S><G><S><F><N><N><W><S><T><K><I><P><L><I><K><S><H><N><D><F><V><A><I><L><D><L><P><E><G><E><H><Q><Y><K><F><F><V><D><G><Q><W><V><H><D><P><S><E><P><V><V><T><S><Q><L><G><T><I><N><N><L><I><H><V><K><K><S><D><F><E><V><F><D><A><L><K><L><D><S><M><E><S><S><E><T><S><C><R><D><L><S><S><S><P><P><G><P><Y><G><Q><E><M><Y><A><F><R><S><E><E><R><F><K><S><P><P><I><L><P><P><H><L><L><Q><V><I><L><N><K><D><T><N><I><S><C><D><P><A><L><L><P><E><P><N><H><V><M><L><N><H><L><Y><A><L><S><I><K><D><S><V><M><V><L><S><A><T><H><R><Y><K><K><K><Y><V><T><T><L><L><Y><K><P><I>
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).<BOP>
O43741
P20592
MX2_HUMAN
p78-related protein
Homo
<M><S><K><A><H><K><P><W><P><Y><R><R><R><S><Q><F><S><S><R><K><Y><L><K><K><E><M><N><S><F><Q><Q><Q><P><P><P><F><G><T><V><P><P><Q><M><M><F><P><P><N><W><Q><G><A><E><K><D><A><A><F><L><A><K><D><F><N><F><L><T><L><N><N><Q><P><P><P><G><N><R><S><Q><P><R><A><M><G><P><E><N><N><L><Y><S><Q><Y><E><Q><K><V><R><P><C><I><D><L><I><D><S><L><R><A><L><G><V><E><Q><D><L><A><L><P><A><I><A><V><I><G><D><Q><S><S><G><K><S><S><V><L><E><A><L><S><G><V><A><L><P><R><G><S><G><I><V><T><R><C><P><L><V><L><K><L><K><K><Q><P><C><E><A><W><A><G><R><I><S><Y><R><N><T><E><L><E><L><Q><D><P><G><Q><V><E><K><E><I><H><K><A><Q><N><V><M><A><G><N><G><R><G><I><S><H><E><L><I><S><L><E><I><T><S><P><E><V><P><D><L><T><I><I><D><L><P><G><I><T><R><V><A><V><D><N><Q><P><R><D><I><G><L><Q><I><K><A><L><I><K><K><Y><I><Q><R><Q><Q><T><I><N><L><V><V><V><P><C><N><V><D><I><A><T><T><E><A><L><S><M><A><H><E><V><D><P><E><G><D><R><T><I><G><I><L><T><K><P><D><L><M><D><R><G><T><E><K><S><V><M><N><V><V><R><N><L><T><Y><P><L><K><K><G><Y><M><I><V><K><C><R><G><Q><Q><E><I><T><N><R><L><S><L><A><E><A><T><K><K><E><I><T><F><F><Q><T><H><P><Y><F><R><V><L><L><E><E><G><S><A><T><V><P><R><L><A><E><R><L><T><T><E><L><I><M><H><I><Q><K><S><L><P><L><L><E><G><Q><I><R><E><S><H><Q><K><A><T><E><E><L><R><R><C><G><A><D><I><P><S><Q><E><A><D><K><M><F><F><L><I><E><K><I><K><M><F><N><Q><D><I><E><K><L><V><E><G><E><E><V><V><R><E><N><E><T><R><L><Y><N><K><I><R><E><D><F><K><N><W><V><G><I><L><A><T><N><T><Q><K><V><K><N><I><I><H><E><E><V><E><K><Y><E><K><Q><Y><R><G><K><E><L><L><G><F><V><N><Y><K><T><F><E><I><I><V><H><Q><Y><I><Q><Q><L><V><E><P><A><L><S><M><L><Q><K><A><M><E><I><I><Q><Q><A><F><I><N><V><A><K><K><H><F><G><E><F><F><N><L><N><Q><T><V><Q><S><T><I><E><D><I><K><V><K><H><T><A><K><A><E><N><M><I><Q><L><Q><F><R><M><E><Q><M><V><F><C><Q><D><Q><I><Y><S><V><V><L><K><K><V><R><E><E><I><F><N><P><L><G><T><P><S><Q><N><M><K><L><N><S><H><F><P><S><N><E><S><S><V><S><S><F><T><E><I><G><I><H><L><N><A><Y><F><L><E><T><S><K><R><L><A><N><Q><I><P><F><I><I><Q><Y><F><M><L><R><E><N><G><D><S><L><Q><K><A><M><M><Q><I><L><Q><E><K><N><R><Y><S><W><L><L><Q><E><Q><S><E><T><A><T><K><R><R><I><L><K><E><R><I><Y><R><L><T><Q><A><R><H><A><L><C><Q><F><S><S><K><E><I><H>
Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.<BOP>
P20592
O14610
GBGT2_HUMAN
Guanine nucleotide binding protein gamma transducing activity polypeptide 2
Homo
<M><A><Q><D><L><S><E><K><D><L><L><K><M><E><V><E><Q><L><K><K><E><V><K><N><T><R><I><P><I><S><K><A><G><K><E><I><K><E><Y><V><E><A><Q><A><G><N><D><P><F><L><K><G><I><P><E><D><K><N><P><F><K><E><K><G><G><C><L><I><S>
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<BOP>
O14610
Q06416
P5F1B_HUMAN
Octamer-binding transcription factor 3-like
Homo
<M><A><G><H><L><A><S><D><F><A><F><S><P><P><P><G><G><G><G><D><G><P><W><G><A><E><P><G><W><V><D><P><L><T><W><L><S><F><Q><G><P><P><G><G><P><G><I><G><P><G><V><G><P><G><S><E><V><W><G><I><P><P><C><P><P><P><Y><E><L><C><G><G><M><A><Y><C><G><P><Q><V><G><V><G><L><V><P><Q><G><G><L><E><T><S><Q><P><E><S><E><A><G><V><G><V><E><S><N><S><N><G><A><S><P><E><P><C><T><V><P><P><G><A><V><K><L><E><K><E><K><L><E><Q><N><P><E><K><S><Q><D><I><K><A><L><Q><K><E><L><E><Q><F><A><K><L><L><K><Q><K><R><I><T><L><G><Y><T><Q><A><D><V><G><L><I><L><G><V><L><F><G><K><V><F><S><Q><K><T><I><C><R><F><E><A><L><Q><L><S><F><K><N><M><C><K><L><R><P><L><L><Q><K><W><V><E><E><A><D><N><N><E><N><L><Q><E><I><C><K><A><E><T><L><M><Q><A><R><K><R><K><R><T><S><I><E><N><R><V><R><G><N><L><E><N><L><F><L><Q><C><P><K><P><T><L><Q><I><S><H><I><A><Q><Q><L><G><L><E><K><D><V><V><R><V><W><F><C><N><R><R><Q><K><G><K><R><S><S><S><D><Y><A><Q><R><E><D><F><E><A><A><G><S><P><F><S><G><G><P><V><S><F><P><P><A><P><G><P><H><F><G><T><P><G><Y><G><S><P><H><F><T><A><L><Y><S><S><V><P><F><P><E><G><E><V><F><P><P><V><S><V><I><T><L><G><S><P><M><H><S><N>
Shows weak transcriptional activator activity.<BOP>
Q06416
Q96SL4
GPX7_HUMAN
CL683
Homo
<M><V><A><A><T><V><A><A><A><W><L><L><L><W><A><A><A><C><A><Q><Q><E><Q><D><F><Y><D><F><K><A><V><N><I><R><G><K><L><V><S><L><E><K><Y><R><G><S><V><S><L><V><V><N><V><A><S><E><C><G><F><T><D><Q><H><Y><R><A><L><Q><Q><L><Q><R><D><L><G><P><H><H><F><N><V><L><A><F><P><C><N><Q><F><G><Q><Q><E><P><D><S><N><K><E><I><E><S><F><A><R><R><T><Y><S><V><S><F><P><M><F><S><K><I><A><V><T><G><T><G><A><H><P><A><F><K><Y><L><A><Q><T><S><G><K><E><P><T><W><N><F><W><K><Y><L><V><A><P><D><G><K><V><V><G><A><W><D><P><T><V><S><V><E><E><V><R><P><Q><I><T><A><L><V><R><K><L><I><L><L><K><R><E><D><L>
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.<BOP>
Q96SL4
P62424
RL7A_HUMAN
Surfeit locus protein 3
Homo
<M><P><K><G><K><K><A><K><G><K><K><V><A><P><A><P><A><V><V><K><K><Q><E><A><K><K><V><V><N><P><L><F><E><K><R><P><K><N><F><G><I><G><Q><D><I><Q><P><K><R><D><L><T><R><F><V><K><W><P><R><Y><I><R><L><Q><R><Q><R><A><I><L><Y><K><R><L><K><V><P><P><A><I><N><Q><F><T><Q><A><L><D><R><Q><T><A><T><Q><L><L><K><L><A><H><K><Y><R><P><E><T><K><Q><E><K><K><Q><R><L><L><A><R><A><E><K><K><A><A><G><K><G><D><V><P><T><K><R><P><P><V><L><R><A><G><V><N><T><V><T><T><L><V><E><N><K><K><A><Q><L><V><V><I><A><H><D><V><D><P><I><E><L><V><V><F><L><P><A><L><C><R><K><M><G><V><P><Y><C><I><I><K><G><K><A><R><L><G><R><L><V><H><R><K><T><C><T><T><V><A><F><T><Q><V><N><S><E><D><K><G><A><L><A><K><L><V><E><A><I><R><T><N><Y><N><D><R><Y><D><E><I><R><R><H><W><G><G><N><V><L><G><P><K><S><V><A><R><I><A><K><L><E><K><A><K><A><K><E><L><A><T><K><L><G>
Component of the large ribosomal subunit . The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell .<BOP>
P62424
Q58FG1
HS904_HUMAN
Heat shock protein 90-alpha D
Homo
<M><E><S><L><T><D><P><S><K><L><D><S><G><K><E><P><H><I><S><L><I><P><N><K><Q><D><R><T><L><T><I><V><D><T><G><I><G><M><T><K><A><D><L><I><N><N><L><G><T><I><T><K><S><E><T><K><V><F><M><E><V><L><Q><A><G><A><D><I><S><M><I><G><Q><F><S><V><G><F><Y><S><A><Y><S><V><A><E><K><V><T><V><I><T><K><H><N><N><D><E><Q><Y><A><W><E><S><S><L><R><G><S><F><T><E><Y><R><E><F><Y><K><S><L><T><I><N><W><E><D><Y><L><A><V><K><H><F><S><V><E><G><Q><L><E><F><R><A><F><L><F><V><P><R><L><A><P><F><E><L><L><E><T><R><K><K><K><N><K><I><K><L><S><A><R><R><D><L><I><M><D><N><C><E><E><L><I><P><E><Y><L><N><F><I><R><G><V><V><D><S><E><D><L><P><L><N><I><F><R><E><T><K><D><Q><V><A><N><S><T><I><V><Q><R><L><W><K><H><G><L><E><V><I><Y><T><I><E><P><I><D><E><Y><C><V><Q><Q><L><K><E><F><E><G><K><T><L><V><S><V><T><K><E><D><L><E><L><P><E><D><E><E><E><K><K><K><Q><E><E><G><K><Q><K><T><K><Q><K><K><N><Q><S><L><R><T><S><A><K><S><T><Y><G><W><T><A><N><M><E><R><I><M><K><A><Q><A><L><R><D><N><S><T><T><G><Y><M><A><A><K><K><H><L><E><I><N><P><D><H><S><F><I><D><T><L><R><Q><K><A><E><T><D><K><N><D><K><S><V><K><D><L><V><I><L><L><Y><E><T><A><L><L><S><S><D><F><G><L><E><G><P><Q><T><H><A><N><R><I><Y><R><M><N><K><L><G><L><G><T><D><E><D><D><P><T><A><D><D><T><S><A><A><V><T><E><E><M><P><P><L><E><G><D><D><D><T><S><R><M><E><K>
Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.<BOP>
Q58FG1
Q9UBU7
DBF4A_HUMAN
DBF4-type zinc finger-containing protein 1
Homo
<M><N><S><G><A><M><R><I><H><S><K><G><H><F><Q><G><G><I><Q><V><K><N><E><K><N><R><P><S><L><K><S><L><K><T><D><N><R><P><E><K><S><K><C><K><P><L><W><G><K><V><F><Y><L><D><L><P><S><V><T><I><S><E><K><L><Q><K><D><I><K><D><L><G><G><R><V><E><E><F><L><S><K><D><I><S><Y><L><I><S><N><K><K><E><A><K><F><A><Q><T><L><G><R><I><S><P><V><P><S><P><E><S><A><Y><T><A><E><T><T><S><P><H><P><S><H><D><G><S><S><F><K><S><P><D><T><V><C><L><S><R><G><K><L><L><V><E><K><A><I><K><D><H><D><F><I><P><S><N><S><I><L><S><N><A><L><S><W><G><V><K><I><L><H><I><D><D><I><R><Y><Y><I><E><Q><K><K><K><E><L><Y><L><L><K><K><S><S><T><S><V><R><D><G><G><K><R><V><G><S><G><A><Q><K><T><R><T><G><R><L><K><K><P><F><V><K><V><E><D><M><S><Q><L><Y><R><P><F><Y><L><Q><L><T><N><M><P><F><I><N><Y><S><I><Q><K><P><C><S><P><F><D><V><D><K><P><S><S><M><Q><K><Q><T><Q><V><K><L><R><I><Q><T><D><G><D><K><Y><G><G><T><S><I><Q><L><Q><L><K><E><K><K><K><K><G><Y><C><E><C><C><L><Q><K><Y><E><D><L><E><T><H><L><L><S><E><Q><H><R><N><F><A><Q><S><N><Q><Y><Q><V><V><D><D><I><V><S><K><L><V><F><D><F><V><E><Y><E><K><D><T><P><K><K><K><R><I><K><Y><S><V><G><S><L><S><P><V><S><A><S><V><L><K><K><T><E><Q><K><E><K><V><E><L><Q><H><I><S><Q><K><D><C><Q><E><D><D><T><T><V><K><E><Q><N><F><L><Y><K><E><T><Q><E><T><E><K><K><L><L><F><I><S><E><P><I><P><H><P><S><N><E><L><R><G><L><N><E><K><M><S><N><K><C><S><M><L><S><T><A><E><D><D><I><R><Q><N><F><T><Q><L><P><L><H><K><N><K><Q><E><C><I><L><D><I><S><E><H><T><L><S><E><N><D><L><E><E><L><R><V><D><H><Y><K><C><N><I><Q><A><S><V><H><V><S><D><F><S><T><D><N><S><G><S><Q><P><K><Q><K><S><D><T><V><L><F><P><A><K><D><L><K><E><K><D><L><H><S><I><F><T><H><D><S><G><L><I><T><I><N><S><S><Q><E><H><L><T><V><Q><A><K><A><P><F><H><T><P><P><E><E><P><N><E><C><D><F><K><N><M><D><S><L><P><S><G><K><I><H><R><K><V><K><I><I><L><G><R><N><R><K><E><N><L><E><P><N><A><E><F><D><K><R><T><E><F><I><T><Q><E><E><N><R><I><C><S><S><P><V><Q><S><L><L><D><L><F><Q><T><S><E><E><K><S><E><F><L><G><F><T><S><Y><T><E><K><S><G><I><C><N><V><L><D><I><W><E><E><E><N><S><D><N><L><L><T><A><F><F><S><S><P><S><T><S><T><F><T><G><F>
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.<BOP>
Q9UBU7