accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q5H9L2
TCAL5_HUMAN
Transcription elongation factor S-II protein-like 5
Homo
<M><E><K><L><Y><K><E><N><E><G><K><P><E><N><E><R><N><L><E><S><E><G><K><P><E><D><E><G><S><T><E><D><E><G><K><S><D><E><E><E><K><P><D><M><E><G><K><T><E><C><E><G><K><R><E><D><E><G><E><P><G><D><E><G><Q><L><E><D><E><G><N><Q><E><K><Q><G><K><S><E><G><E><D><K><P><Q><S><E><G><K><P><A><S><Q><A><K><P><E><S><Q><P><R><A><A><E><K><R><P><A><E><D><Y><V><P><R><K><A><K><R><K><T><D><R><G><T><D><D><S><P><K><D><S><Q><E><D><L><Q><E><R><H><L><S><S><E><E><M><M><R><E><C><G><D><V><S><R><A><Q><E><E><L><R><K><K><Q><K><M><G><G><F><H><W><M><Q><R><D><V><Q><D><P><F><A><P><R><G><Q><R><G><V><R><G><V><R><G><G><G><R><G><Q><K><D><L><E><D><V><P><Y><V>
May be involved in transcriptional regulation.<BOP>
Q5H9L2
P16444
DPEP1_HUMAN
Renal dipeptidase
Homo
<M><W><S><G><W><W><L><W><P><L><V><A><V><C><T><A><D><F><F><R><D><E><A><E><R><I><M><R><D><S><P><V><I><D><G><H><N><D><L><P><W><Q><L><L><D><M><F><N><N><R><L><Q><D><E><R><A><N><L><T><T><L><A><G><T><H><T><N><I><P><K><L><R><A><G><F><V><G><G><Q><F><W><S><V><Y><T><P><C><D><T><Q><N><K><D><A><V><R><R><T><L><E><Q><M><D><V><V><H><R><M><C><R><M><Y><P><E><T><F><L><Y><V><T><S><S><A><G><I><R><Q><A><F><R><E><G><K><V><A><S><L><I><G><V><E><G><G><H><S><I><D><S><S><L><G><V><L><R><A><L><Y><Q><L><G><M><R><Y><L><T><L><T><H><S><C><N><T><P><W><A><D><N><W><L><V><D><T><G><D><S><E><P><Q><S><Q><G><L><S><P><F><G><Q><R><V><V><K><E><L><N><R><L><G><V><L><I><D><L><A><H><V><S><V><A><T><M><K><A><T><L><Q><L><S><R><A><P><V><I><F><S><H><S><S><A><Y><S><V><C><A><S><R><R><N><V><P><D><D><V><L><R><L><V><K><Q><T><D><S><L><V><M><V><N><F><Y><N><N><Y><I><S><C><T><N><K><A><N><L><S><Q><V><A><D><H><L><D><H><I><K><E><V><A><G><A><R><A><V><G><F><G><G><D><F><D><G><V><P><R><V><P><E><G><L><E><D><V><S><K><Y><P><D><L><I><A><E><L><L><R><R><N><W><T><E><A><E><V><K><G><A><L><A><D><N><L><L><R><V><F><E><A><V><E><Q><A><S><N><L><T><Q><A><P><E><E><E><P><I><P><L><D><Q><L><G><G><S><C><R><T><H><Y><G><Y><S><S><G><A><S><S><L><H><R><H><W><G><L><L><L><A><S><L><A><P><L><V><L><C><L><S><L><L>
Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.<BOP>
P16444
Q9ULM2
ZN490_HUMAN
Zinc finger protein 490
Homo
<M><R><R><N><S><S><L><S><F><Q><M><E><R><P><L><E><E><Q><V><Q><S><K><W><S><S><S><Q><G><R><T><G><T><G><G><S><D><V><L><Q><M><Q><N><S><E><H><H><G><Q><S><I><K><T><Q><T><D><S><I><S><L><E><D><V><A><V><N><F><T><L><E><E><W><A><L><L><D><P><G><Q><R><N><I><Y><R><D><V><M><R><A><T><F><K><N><L><A><C><I><G><E><K><W><K><D><Q><D><I><E><D><E><H><K><N><Q><G><R><N><L><R><S><P><M><V><E><A><L><C><E><N><K><E><D><C><P><C><G><K><S><T><S><Q><I><P><D><L><N><T><N><L><E><T><P><T><G><L><K><P><C><D><C><S><V><C><G><E><V><F><M><H><Q><V><S><L><N><R><H><M><R><S><H><T><E><Q><K><P><N><E><C><H><E><Y><G><E><K><P><H><K><C><K><E><C><G><K><T><F><T><R><S><S><S><I><R><T><H><E><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><A><F><L><F><S><F><R><N><H><I><R><I><H><T><G><E><T><P><Y><E><C><K><E><C><G><K><A><F><R><Y><L><T><A><L><R><R><H><E><K><N><H><T><G><E><K><P><Y><K><C><K><Q><C><G><K><A><F><I><Y><Y><Q><P><F><L><T><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><S><C><P><T><Y><L><R><S><H><E><K><T><H><T><G><E><K><P><F><V><C><R><E><C><G><R><A><F><F><S><H><S><S><L><R><K><H><V><K><T><H><T><G><V><Q><P><Y><T><C><K><K><C><G><E><A><F><K><S><S><S><S><C><E><V><H><E><R><T><H><F><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><N><S><S><S><Y><L><Q><L><H><E><R><V><H><T><G><E><K><T><Y><E><C><K><E><C><G><K><A><F><L><Y><S><T><H><F><R><I><H><E><R><T><H><T><R><E><K><P><Y><E><C><K><Q><C><G><R><V><F><I><Y><F><S><H><L><R><R><H><E><R><S><H><T><G><V><K><P><C><E><C><K><Q><C><G><K><A><F><T><C><L><N><S><L><K><V><H><K><R><I><H><T><G><E><R><P><F><Q><C><R><Q><C><G><K><A><F><S><Y><S><K><S><L><H><V><H><E><R><T><H><S><R><Q><K><P>
May be involved in transcriptional regulation.<BOP>
Q9ULM2
Q06587
RING1_HUMAN
Really interesting new gene 1 protein
Homo
<M><T><T><P><A><N><A><Q><N><A><S><K><T><W><E><L><S><L><Y><E><L><H><R><T><P><Q><E><A><I><M><D><G><T><E><I><A><V><S><P><R><S><L><H><S><E><L><M><C><P><I><C><L><D><M><L><K><N><T><M><T><T><K><E><C><L><H><R><F><C><S><D><C><I><V><T><A><L><R><S><G><N><K><E><C><P><T><C><R><K><K><L><V><S><K><R><S><L><R><P><D><P><N><F><D><A><L><I><S><K><I><Y><P><S><R><E><E><Y><E><A><H><Q><D><R><V><L><I><R><L><S><R><L><H><N><Q><Q><A><L><S><S><S><I><E><E><G><L><R><M><Q><A><M><H><R><A><Q><R><V><R><R><P><I><P><G><S><D><Q><T><T><T><M><S><G><G><E><G><E><P><G><E><G><E><G><D><G><E><D><V><S><S><D><S><A><P><D><S><A><P><G><P><A><P><K><R><P><R><G><G><G><A><G><G><S><S><V><G><T><G><G><G><G><T><G><G><V><G><G><G><A><G><S><E><D><S><G><D><R><G><G><T><L><G><G><G><T><L><G><P><P><S><P><P><G><A><P><S><P><P><E><P><G><G><E><I><E><L><V><F><R><P><H><P><L><L><V><E><K><G><E><Y><C><Q><T><R><Y><V><K><T><T><G><N><A><T><V><D><H><L><S><K><Y><L><A><L><R><I><A><L><E><R><R><Q><Q><Q><E><A><G><E><P><G><G><P><G><G><G><A><S><D><T><G><G><P><D><G><C><G><G><E><G><G><G><A><G><G><G><D><G><P><E><E><P><A><L><P><S><L><E><G><V><S><E><K><Q><Y><T><I><Y><I><A><P><G><G><G><A><F><T><T><L><N><G><S><L><T><L><E><L><V><N><E><K><F><W><K><V><S><R><P><L><E><L><C><Y><A><P><T><K><D><P><K>
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.<BOP>
Q06587
Q8WWU5
TCP11_HUMAN
T-complex protein 11 homolog
Homo
<M><P><D><V><K><E><S><V><P><P><K><Y><P><G><D><S><E><G><R><S><C><K><P><E><T><S><G><P><P><Q><E><D><K><S><G><S><E><D><P><P><P><F><L><S><V><T><G><L><T><E><T><V><N><E><V><S><K><L><S><N><K><I><G><M><N><C><D><Y><Y><M><E><E><K><V><L><P><P><S><S><L><E><G><K><V><K><E><T><V><H><N><A><F><W><D><H><L><K><E><Q><L><S><A><T><P><P><D><F><S><C><A><L><E><L><L><K><E><I><K><E><I><L><L><S><L><L><L><P><R><Q><N><R><L><R><I><E><I><E><E><A><L><D><M><D><L><L><K><Q><E><A><E><H><G><A><L><K><V><L><Y><L><S><K><Y><V><L><N><M><M><A><L><L><C><A><P><V><R><D><E><A><V><Q><K><L><E><N><I><T><D><P><V><W><L><L><R><G><I><F><Q><V><L><G><R><M><K><M><D><M><V><N><Y><T><I><Q><S><L><Q><P><H><L><Q><E><H><S><I><Q><Y><E><R><A><K><F><Q><E><L><L><N><K><Q><P><S><L><L><N><H><T><T><K><W><L><T><Q><A><A><G><D><L><T><M><S><P><P><T><C><P><D><T><S><D><S><S><S><V><A><G><P><S><P><N><E><A><A><N><N><P><E><P><L><S><P><T><M><V><L><C><Q><G><F><L><N><L><L><L><W><D><L><E><N><E><E><F><P><E><T><L><L><M><D><R><T><R><L><Q><E><L><K><S><Q><L><H><Q><L><T><V><M><A><S><V><L><L><V><A><S><S><F><S><G><S><V><L><F><G><S><P><Q><F><V><D><K><L><K><R><I><T><K><S><L><L><E><D><F><H><S><R><P><E><E><A><I><L><T><V><S><E><Q><V><S><Q><E><I><H><Q><S><L><K><N><M><G><L><V><A><L><S><S><D><N><T><A><S><L><M><G><Q><L><Q><N><I><A><K><K><E><N><C><V><C><S><V><I><D><Q><R><I><H><L><F><L><K><C><C><L><V><L><G><V><Q><R><S><L><L><D><L><P><G><G><L><T><L><I><E><A><E><L><A><E><L><G><Q><K><F><V><N><L><T><H><H><N><Q><Q><V><F><G><P><Y><Y><T><E><I><L><K><T><L><I><S><P><A><Q><A><L><E><T><K><V><E><S><V>
Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway.<BOP>
Q8WWU5
Q9HAT8
PELI2_HUMAN
RING-type E3 ubiquitin transferase pellino homolog 2
Homo
<M><F><S><P><G><Q><E><E><H><C><A><P><N><K><E><P><V><K><Y><G><E><L><V><V><L><G><Y><N><G><A><L><P><N><G><D><R><G><R><R><K><S><R><F><A><L><Y><K><R><P><K><A><N><G><V><K><P><S><T><V><H><V><I><S><T><P><Q><A><S><K><A><I><S><C><K><G><Q><H><S><I><S><Y><T><L><S><R><N><Q><T><V><V><V><E><Y><T><H><D><K><D><T><D><M><F><Q><V><G><R><S><T><E><S><P><I><D><F><V><V><T><D><T><I><S><G><S><Q><N><T><D><E><A><Q><I><T><Q><S><T><I><S><R><F><A><C><R><I><V><C><D><R><N><E><P><Y><T><A><R><I><F><A><A><G><F><D><S><S><K><N><I><F><L><G><E><K><A><A><K><W><K><N><P><D><G><H><M><D><G><L><T><T><N><G><V><L><V><M><H><P><R><G><G><F><T><E><E><S><Q><P><G><V><W><R><E><I><S><V><C><G><D><V><Y><T><L><R><E><T><R><S><A><Q><Q><R><G><K><L><V><E><S><E><T><N><V><L><Q><D><G><S><L><I><D><L><C><G><A><T><L><L><W><R><T><A><D><G><L><F><H><T><P><T><Q><K><H><I><E><A><L><R><Q><E><I><N><A><A><R><P><Q><C><P><V><G><L><N><T><L><A><F><P><S><I><N><R><K><E><V><V><E><E><K><Q><P><W><A><Y><L><S><C><G><H><V><H><G><Y><H><N><W><G><H><R><S><D><T><E><A><N><E><R><E><C><P><M><C><R><T><V><G><P><Y><V><P><L><W><L><G><C><E><A><G><F><Y><V><D><A><G><P><P><T><H><A><F><T><P><C><G><H><V><C><S><E><K><S><A><K><Y><W><S><Q><I><P><L><P><H><G><T><H><A><F><H><A><A><C><P><F><C><A><T><Q><L><V><G><E><Q><N><C><I><K><L><I><F><Q><G><P><I><D>
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.<BOP>
Q9HAT8
P11912
CD79A_HUMAN
Surface IgM-associated protein
Homo
<M><P><G><G><P><G><V><L><Q><A><L><P><A><T><I><F><L><L><F><L><L><S><A><V><Y><L><G><P><G><C><Q><A><L><W><M><H><K><V><P><A><S><L><M><V><S><L><G><E><D><A><H><F><Q><C><P><H><N><S><S><N><N><A><N><V><T><W><W><R><V><L><H><G><N><Y><T><W><P><P><E><F><L><G><P><G><E><D><P><N><G><T><L><I><I><Q><N><V><N><K><S><H><G><G><I><Y><V><C><R><V><Q><E><G><N><E><S><Y><Q><Q><S><C><G><T><Y><L><R><V><R><Q><P><P><P><R><P><F><L><D><M><G><E><G><T><K><N><R><I><I><T><A><E><G><I><I><L><L><F><C><A><V><V><P><G><T><L><L><L><F><R><K><R><W><Q><N><E><K><L><G><L><D><A><G><D><E><Y><E><D><E><N><L><Y><E><G><L><N><L><D><D><C><S><M><Y><E><D><I><S><R><G><L><Q><G><T><Y><Q><D><V><G><S><L><N><I><G><D><V><Q><L><E><K><P>
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.<BOP>
P11912
Q14032
BAAT_HUMAN
Long-chain fatty-acyl-CoA hydrolase
Homo
<M><I><Q><L><T><A><T><P><V><S><A><L><V><D><E><P><V><H><I><R><A><T><G><L><I><P><F><Q><M><V><S><F><Q><A><S><L><E><D><E><N><G><D><M><F><Y><S><Q><A><H><Y><R><A><N><E><F><G><E><V><D><L><N><H><A><S><S><L><G><G><D><Y><M><G><V><H><P><M><G><L><F><W><S><L><K><P><E><K><L><L><T><R><L><L><K><R><D><V><M><N><R><P><F><Q><V><Q><V><K><L><Y><D><L><E><L><I><V><N><N><K><V><A><S><A><P><K><A><S><L><T><L><E><R><W><Y><V><A><P><G><V><T><R><I><K><V><R><E><G><R><L><R><G><A><L><F><L><P><P><G><E><G><L><F><P><G><V><I><D><L><F><G><G><L><G><G><L><L><E><F><R><A><S><L><L><A><S><R><G><F><A><S><L><A><L><A><Y><H><N><Y><E><D><L><P><R><K><P><E><V><T><D><L><E><Y><F><E><E><A><A><N><F><L><L><R><H><P><K><V><F><G><S><G><V><G><V><V><S><V><C><Q><G><V><Q><I><G><L><S><M><A><I><Y><L><K><Q><V><T><A><T><V><L><I><N><G><T><N><F><P><F><G><I><P><Q><V><Y><H><G><Q><I><H><Q><P><L><P><H><S><A><Q><L><I><S><T><N><A><L><G><L><L><E><L><Y><R><T><F><E><T><T><Q><V><G><A><S><Q><Y><L><F><P><I><E><E><A><Q><G><Q><F><L><F><I><V><G><E><G><D><K><T><I><N><S><K><A><H><A><E><Q><A><I><G><Q><L><K><R><H><G><K><N><N><W><T><L><L><S><Y><P><G><A><G><H><L><I><E><P><P><Y><S><P><L><C><C><A><S><T><T><H><D><L><R><L><H><W><G><G><E><V><I><P><H><A><A><A><Q><E><H><A><W><K><E><I><Q><R><F><L><R><K><H><L><I><P><D><V><T><S><Q><L>
Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine . More than 95% of the BAs are N-acyl amidates with glycine and taurine . Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism . This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption . May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids . In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs .<BOP>
Q14032
Q13326
SGCG_HUMAN
35 kDa dystrophin-associated glycoprotein
Homo
<M><V><R><E><Q><Y><T><T><A><T><E><G><I><C><I><E><R><P><E><N><Q><Y><V><Y><K><I><G><I><Y><G><W><R><K><R><C><L><Y><L><F><V><L><L><L><L><I><I><L><V><V><N><L><A><L><T><I><W><I><L><K><V><M><W><F><S><P><A><G><M><G><H><L><C><V><T><K><D><G><L><R><L><E><G><E><S><E><F><L><F><P><L><Y><A><K><E><I><H><S><R><V><D><S><S><L><L><L><Q><S><T><Q><N><V><T><V><N><A><R><N><S><E><G><E><V><T><G><R><L><K><V><G><P><K><M><V><E><V><Q><N><Q><Q><F><Q><I><N><S><N><D><G><K><P><L><F><T><V><D><E><K><E><V><V><V><G><T><D><K><L><R><V><T><G><P><E><G><A><L><F><E><H><S><V><E><T><P><L><V><R><A><D><P><F><Q><D><L><R><L><E><S><P><T><R><S><L><S><M><D><A><P><R><G><V><H><I><Q><A><H><A><G><K><I><E><A><L><S><Q><M><D><I><L><F><H><S><S><D><G><M><L><V><L><D><A><E><T><V><C><L><P><K><L><V><Q><G><T><W><G><P><S><G><S><S><Q><S><L><Y><E><I><C><V><C><P><D><G><K><L><Y><L><S><V><A><G><V><S><T><T><C><Q><E><H><N><H><I><C><L>
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.<BOP>
Q13326
P0DSN6
T2R33_HUMAN
Putative taste receptor type 2 member 33
Homo
<M><V><Y><F><L><P><I><I><F><S><I><L><V><V><F><A><F><V><L><G><N><F><S><N><G><F><I><A><L><V><N><V><I><D><W><V><K><R><Q><K><I><S><S><A><D><Q><I><L><T><A><L><V><V><S><R><V><G><L><L><W><V><I><L><L><H><W><Y><A><N><V><F><N><S><A><L><Y><S><L><E><V><R><I><V><A><S><N><I><S><A><V><I><N><H><F><S><I><W><L><A><A><S><L><S><I><F><Y><L><L><K><I><A><N><F><S><N><L><I><F><L><H><L><K><K><R><I><K><S><V><V><L><V><I><L><L><G><P><L><V><F><L><I><C><N><L><A><V><I><T><M><D><E><R><V><W><T><K><E><Y><E><G><N><V><T><W><K><I><K><L><R><N><A><I><H><L><S><S><L><T><V><T><T><L><A><N><L><I><P><F><T><L><S><L><I><C><F><L><L><L><I><C><S><L><C><K><H><L><K><K><M><Q><L><H><S><K><G><S><Q><D><P><S><T><K><V><H><I><K><A><L><Q><T><V><I><S><F><L><M><L><C><A><I><Y><F><L><S><I><M><I><S><V><W><N><L><R><S><L><E><N><K><P><V><F><M><F><C><K><A><I><R><F><S><Y><P><S><I><H><P><F><I><L><I><W><G><N><K><K><L><K><Q><T><F><L><S><V><F><W><Q><V><R><Y><W><V><K><G><E><K><P><S><S><P>
Putative taste receptor which may play a role in the perception of bitterness.<BOP>
P0DSN6
Q9UIG8
SO3A1_HUMAN
Solute carrier family 21 member 11
Homo
<M><Q><G><K><K><P><G><G><S><S><G><G><G><R><S><G><E><L><Q><G><D><E><A><Q><R><N><K><K><K><K><K><K><V><S><C><F><S><N><I><K><I><F><L><V><S><E><C><A><L><M><L><A><Q><G><T><V><G><A><Y><L><V><S><V><L><T><T><L><E><R><R><F><N><L><Q><S><A><D><V><G><V><I><A><S><S><F><E><I><G><N><L><A><L><I><L><F><V><S><Y><F><G><A><R><G><H><R><P><R><L><I><G><C><G><G><I><V><M><A><L><G><A><L><L><S><A><L><P><E><F><L><T><H><Q><Y><K><Y><E><A><G><E><I><R><W><G><A><E><G><R><D><V><C><A><A><N><G><S><G><G><D><E><G><P><D><P><D><L><I><C><R><N><R><T><A><T><N><M><M><Y><L><L><L><I><G><A><Q><V><L><L><G><I><G><A><T><P><V><Q><P><L><G><V><S><Y><I><D><D><H><V><R><R><K><D><S><S><L><Y><I><G><I><L><F><T><M><L><V><F><G><P><A><C><G><F><I><L><G><S><F><C><T><K><I><Y><V><D><A><V><F><I><D><T><S><N><L><D><I><T><P><D><D><P><R><W><I><G><A><W><W><G><G><F><L><L><C><G><A><L><L><F><F><S><S><L><L><M><F><G><F><P><Q><S><L><P><P><H><S><E><P><A><M><E><S><E><Q><A><M><L><S><E><R><E><Y><E><R><P><K><P><S><N><G><V><L><R><H><P><L><E><P><D><S><S><A><S><C><F><Q><Q><L><R><V><I><P><K><V><T><K><H><L><L><S><N><P><V><F><T><C><I><I><L><A><A><C><M><E><I><A><V><V><A><G><F><A><A><F><L><G><K><Y><L><E><Q><Q><F><N><L><T><T><S><S><A><N><Q><L><L><G><M><T><A><I><P><C><A><C><L><G><I><F><L><G><G><L><L><V><K><K><L><S><L><S><A><L><G><A><I><R><M><A><M><L><V><N><L><V><S><T><A><C><Y><V><S><F><L><F><L><G><C><D><T><G><P><V><A><G><V><T><V><P><Y><G><N><S><T><A><P><G><S><A><L><D><P><Y><S><P><C><N><N><N><C><E><C><Q><T><D><S><F><T><P><V><C><G><A><D><G><I><T><Y><L><S><A><C><F><A><G><C><N><S><T><N><L><T><G><C><A><C><L><T><T><V><P><A><E><N><A><T><V><V><P><G><K><C><P><S><P><G><C><Q><E><A><F><L><T><F><L><C><V><M><C><I><C><S><L><I><G><A><M><A><Q><T><P><S><V><I><I><L><I><R><T><V><S><P><E><L><K><S><Y><A><L><G><V><L><F><L><L><L><R><L><L><G><F><I><P><P><P><L><I><F><G><A><G><I><D><S><T><C><L><F><W><S><T><F><C><G><E><Q><G><A><C><V><L><Y><D><N><V><V><Y><R><Y><L><Y><V><S><I><A><I><A><L><K><S><F><A><F><I><L><Y><T><T><T><W><Q><C><L><R><K><N><Y><K><R><Y><I><K><N><H><E><G><G><L><S><T><S><E><F><F><A><S><T><L><T><L><D><N><L><G><R><D><P><V><P><A><N><Q><T><H><R><T><K><F><I><Y><N><L><E><D><H><E><W><C><E><N><M><E><S><V><L>
Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate . Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS .<BOP>
Q9UIG8
Q9NXV6
CARF_HUMAN
Collaborator of ARF
Homo
<M><A><Q><E><V><S><E><Y><L><S><Q><N><P><R><V><A><A><W><V><E><A><L><R><C><D><G><E><T><D><K><H><W><R><H><R><R><D><F><L><L><R><N><A><G><D><L><A><P><A><G><G><A><A><S><A><S><T><D><E><A><A><D><A><E><S><G><T><R><N><R><Q><L><Q><Q><L><I><S><F><S><M><A><W><A><N><H><V><F><L><G><C><R><Y><P><Q><K><V><M><D><K><I><L><S><M><A><E><G><I><K><V><T><D><A><P><T><Y><T><T><R><D><E><L><V><A><K><V><K><K><R><G><I><S><S><S><N><E><G><V><E><E><P><S><K><K><R><V><I><E><G><K><N><S><S><A><V><E><Q><D><H><A><K><T><S><A><K><T><E><R><A><S><A><Q><Q><E><N><S><S><T><C><I><G><S><A><I><K><S><E><S><G><N><S><A><R><S><S><G><I><S><S><Q><N><S><S><T><S><D><G><D><R><S><V><S><S><Q><S><S><S><S><V><S><S><Q><V><T><T><A><G><S><G><K><A><S><E><A><E><A><P><D><K><H><G><S><A><S><F><V><S><L><L><K><S><S><V><N><S><H><M><T><Q><S><T><D><S><R><Q><Q><S><G><S><P><K><K><S><A><L><E><G><S><S><A><S><A><S><Q><S><S><S><E><I><E><V><P><L><L><G><S><S><G><S><S><E><V><E><L><P><L><L><S><S><K><P><S><S><E><T><A><S><S><G><L><T><S><K><T><S><S><E><A><S><V><S><S><S><V><A><K><N><S><S><S><S><G><T><S><L><L><T><P><K><S><S><S><S><T><N><T><S><L><L><T><S><K><S><T><S><Q><V><A><A><S><L><L><A><S><K><S><S><S><Q><T><S><G><S><L><V><S><K><S><T><S><L><A><S><V><S><Q><L><A><S><K><S><S><S><Q><T><S><T><S><Q><L><P><S><K><S><T><S><Q><S><S><E><S><S><V><K><F><S><C><K><L><T><N><E><D><V><K><Q><K><Q><P><F><F><N><R><L><Y><K><T><V><A><W><K><L><V><A><V><G><G><F><S><P><N><V><N><H><G><E><L><L><N><A><A><I><E><A><L><K><A><T><L><D><V><F><F><V><P><L><K><E><L><A><D><L><P><Q><N><K><S><S><Q><E><S><I><V><C><E><L><R><C><K><S><V><Y><L><G><T><G><C><G><K><S><K><E><N><A><K><A><V><A><S><R><E><A><L><K><L><F><L><K><K><K><V><V><V><K><I><C><K><R><K><Y><R><G><S><E><I><E><D><L><V><L><L><D><E><E><S><R><P><V><N><L><P><P><A><L><K><H><P><Q><E><L><L>
Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.<BOP>
Q9NXV6
Q8N5D0
WDTC1_HUMAN
WD and tetratricopeptide repeats protein 1
Homo
<M><A><K><V><N><I><T><R><D><L><I><R><R><Q><I><K><E><R><G><A><L><S><F><E><R><R><Y><H><V><T><D><P><F><I><R><R><L><G><L><E><A><E><L><Q><G><H><S><G><C><V><N><C><L><E><W><N><E><K><G><D><L><L><A><S><G><S><D><D><Q><H><T><I><V><W><D><P><L><H><H><K><K><L><L><S><M><H><T><G><H><T><A><N><I><F><S><V><K><F><L><P><H><A><G><D><R><I><L><I><T><G><A><A><D><S><K><V><H><V><H><D><L><T><V><K><E><T><I><H><M><F><G><D><H><T><N><R><V><K><R><I><A><T><A><P><M><W><P><N><T><F><W><S><A><A><E><D><G><L><I><R><Q><Y><D><L><R><E><N><S><K><H><S><E><V><L><I><D><L><T><E><Y><C><G><Q><L><V><E><A><K><C><L><T><V><N><P><Q><D><N><N><C><L><A><V><G><A><S><G><P><F><V><R><L><Y><D><I><R><M><I><H><N><H><R><K><S><M><K><Q><S><P><S><A><G><V><H><T><F><C><D><R><Q><K><P><L><P><D><G><A><A><Q><Y><Y><V><A><G><H><L><P><V><K><L><P><D><Y><N><N><R><L><R><V><L><V><A><T><Y><V><T><F><S><P><N><G><T><E><L><L><V><N><M><G><G><E><Q><V><Y><L><F><D><L><T><Y><K><Q><R><P><Y><T><F><L><L><P><R><K><C><H><S><S><G><E><V><Q><N><G><K><M><S><T><N><G><V><S><N><G><V><S><N><G><L><H><L><H><S><N><G><F><R><L><P><E><S><R><G><H><V><S><P><Q><V><E><L><P><P><Y><L><E><R><V><K><Q><Q><A><N><E><A><F><A><C><Q><Q><W><T><Q><A><I><Q><L><Y><S><K><A><V><Q><R><A><P><H><N><A><M><L><Y><G><N><R><A><A><A><Y><M><K><R><K><W><D><G><D><H><Y><D><A><L><R><D><C><L><K><A><I><S><L><N><P><C><H><L><K><A><H><F><R><L><A><R><C><L><F><E><L><K><Y><V><A><E><A><L><E><C><L><D><D><F><K><G><K><F><P><E><Q><A><H><S><S><A><C><D><A><L><G><R><D><I><T><A><A><L><F><S><K><N><D><G><E><E><K><K><G><P><G><G><G><A><P><V><R><L><R><S><T><S><R><K><D><S><I><S><E><D><E><M><V><L><R><E><R><S><Y><D><Y><Q><F><R><Y><C><G><H><C><N><T><T><T><D><I><K><E><A><N><F><F><G><S><N><A><Q><Y><I><V><S><G><S><D><D><G><S><F><F><I><W><E><K><E><T><T><N><L><V><R><V><L><Q><G><D><E><S><I><V><N><C><L><Q><P><H><P><S><Y><C><F><L><A><T><S><G><I><D><P><V><V><R><L><W><N><P><R><P><E><S><E><D><L><T><G><R><V><V><E><D><M><E><G><A><S><Q><A><N><Q><R><R><M><N><A><D><P><L><E><V><M><L><L><N><M><G><Y><R><I><T><G><L><S><S><G><G><A><G><A><S><D><D><E><D><S><S><E><G><Q><V><Q><C><R><P><S>
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.<BOP>
Q8N5D0
A8MV23
SERP3_HUMAN
Serpin E3
Homo
<M><P><P><F><L><I><T><L><F><L><F><H><S><C><C><L><R><A><N><G><H><L><R><E><G><M><T><L><L><K><T><E><F><A><L><H><L><Y><Q><S><V><A><A><C><R><N><E><T><N><F><V><I><S><P><A><G><V><S><L><P><L><E><I><L><Q><F><G><A><E><G><S><T><G><Q><Q><L><A><D><A><L><G><Y><T><V><H><D><K><R><V><K><D><F><L><H><A><V><Y><A><T><L><P><T><S><S><Q><G><T><E><M><E><L><A><C><S><L><F><V><Q><V><G><T><P><L><S><P><C><F><V><E><H><V><S><W><W><A><N><S><S><L><E><P><A><D><L><S><E><P><N><S><T><A><I><Q><T><S><E><G><A><S><R><E><T><A><G><G><G><P><S><E><G><P><G><G><W><P><W><E><Q><V><S><A><A><F><A><Q><L><V><L><V><S><T><M><S><F><Q><G><T><W><R><K><R><F><S><S><T><D><T><Q><I><L><P><F><T><C><A><Y><G><L><V><L><Q><V><P><M><M><H><Q><T><T><E><V><N><Y><G><Q><F><Q><D><T><A><G><H><Q><V><G><V><L><E><L><P><Y><L><G><S><A><V><S><L><F><L><V><L><P><R><D><K><D><T><P><L><S><H><I><E><P><H><L><T><A><S><T><I><H><L><W><T><T><S><L><R><R><A><R><M><D><V><F><L><P><R><F><R><I><Q><N><Q><F><N><L><K><S><I><L><N><S><W><G><V><T><D><L><F><D><P><L><K><A><N><L><K><G><I><S><G><Q><D><G><F><Y><V><S><E><A><I><H><K><A><K><I><E><V><L><E><E><G><T><K><A><S><G><A><T><A><L><L><L><L><K><R><S><R><I><P><I><F><K><A><D><R><P><F><I><Y><F><L><R><E><P><N><T><G><I><T><V><F><F><D><R><I><Q><I><I><Y><Q><C><L><S><S><N><K><G><S><F><V><H><Y><P><L><K><N><K><H><S><F>
Probable serine protease inhibitor.<BOP>
A8MV23
Q53G44
IF44L_HUMAN
Interferon-induced protein 44-like
Homo
<M><E><V><T><T><R><L><T><W><N><D><E><N><H><L><R><K><L><L><G><N><V><S><L><S><L><L><Y><K><S><S><V><H><G><G><S><I><E><D><M><V><E><R><C><S><R><Q><G><C><T><I><T><M><A><Y><I><D><Y><N><M><I><V><A><F><M><L><G><N><Y><I><N><L><H><E><S><S><T><E><P><N><D><S><L><W><F><S><L><Q><K><K><N><D><T><T><E><I><E><T><L><L><L><N><T><A><P><K><I><I><D><E><Q><L><V><C><R><L><S><K><T><D><I><F><I><I><C><R><D><N><K><I><Y><L><D><K><M><I><T><R><N><L><K><L><R><F><Y><G><H><R><Q><Y><L><E><C><E><V><F><R><V><E><G><I><K><D><N><L><D><D><I><K><R><I><I><K><A><R><E><H><R><N><R><L><L><A><D><I><R><D><Y><R><P><Y><A><D><L><V><S><E><I><R><I><L><L><V><G><P><V><G><S><G><K><S><S><F><F><N><S><V><K><S><I><F><H><G><H><V><T><G><Q><A><V><V><G><S><D><I><T><S><I><T><E><R><Y><R><I><Y><S><V><K><D><G><K><N><G><K><S><L><P><F><M><L><C><D><T><M><G><L><D><G><A><E><G><A><G><L><C><M><D><D><I><P><H><I><L><K><G><C><M><P><D><R><Y><Q><F><N><S><R><K><P><I><T><P><E><H><S><T><F><I><T><S><P><S><L><K><D><R><I><H><C><V><A><Y><V><L><D><I><N><S><I><D><N><L><Y><S><K><M><L><A><K><V><K><Q><V><H><K><E><V><L><N><C><G><I><A><Y><V><A><L><L><T><K><V><D><D><C><S><E><V><L><Q><D><N><F><L><N><M><S><R><S><M><T><S><Q><S><R><V><M><N><V><H><K><M><L><G><I><P><I><S><N><I><L><M><V><G><N><Y><A><S><D><L><E><L><D><P><M><K><D><I><L><I><L><S><A><L><R><Q><M><L><R><A><A><D><D><F><L><E><D><L><P><L><E><E><T><G><A><I><E><R><A><L><Q><P><C><I>
Type I interferon-stimulated gene (ISG) that plays a critical role in antiviral and antibacterial activity . During bacterial infection, promotes macrophage differentiation and facilitates inflammatory cytokine secretion . Plays a role in the control of respiratory syncytial virus/RSV infection, reducing the ability of the virus to replicate . Exhibits a low antiviral activity against hepatitis C virus . Acts also as a feedback regulator of IFN responses by negatively regulating IKBKB and IKBKE kinase activities through interaction with FKBP5 .<BOP>
Q53G44
P22309
UD11_HUMAN
UDP-glucuronosyltransferase 1A isoform 1
Homo
<M><A><V><E><S><Q><G><G><R><P><L><V><L><G><L><L><L><C><V><L><G><P><V><V><S><H><A><G><K><I><L><L><I><P><V><D><G><S><H><W><L><S><M><L><G><A><I><Q><Q><L><Q><Q><R><G><H><E><I><V><V><L><A><P><D><A><S><L><Y><I><R><D><G><A><F><Y><T><L><K><T><Y><P><V><P><F><Q><R><E><D><V><K><E><S><F><V><S><L><G><H><N><V><F><E><N><D><S><F><L><Q><R><V><I><K><T><Y><K><K><I><K><K><D><S><A><M><L><L><S><G><C><S><H><L><L><H><N><K><E><L><M><A><S><L><A><E><S><S><F><D><V><M><L><T><D><P><F><L><P><C><S><P><I><V><A><Q><Y><L><S><L><P><T><V><F><F><L><H><A><L><P><C><S><L><E><F><E><A><T><Q><C><P><N><P><F><S><Y><V><P><R><P><L><S><S><H><S><D><H><M><T><F><L><Q><R><V><K><N><M><L><I><A><F><S><Q><N><F><L><C><D><V><V><Y><S><P><Y><A><T><L><A><S><E><F><L><Q><R><E><V><T><V><Q><D><L><L><S><S><A><S><V><W><L><F><R><S><D><F><V><K><D><Y><P><R><P><I><M><P><N><M><V><F><V><G><G><I><N><C><L><H><Q><N><P><L><S><Q><E><F><E><A><Y><I><N><A><S><G><E><H><G><I><V><V><F><S><L><G><S><M><V><S><E><I><P><E><K><K><A><M><A><I><A><D><A><L><G><K><I><P><Q><T><V><L><W><R><Y><T><G><T><R><P><S><N><L><A><N><N><T><I><L><V><K><W><L><P><Q><N><D><L><L><G><H><P><M><T><R><A><F><I><T><H><A><G><S><H><G><V><Y><E><S><I><C><N><G><V><P><M><V><M><M><P><L><F><G><D><Q><M><D><N><A><K><R><M><E><T><K><G><A><G><V><T><L><N><V><L><E><M><T><S><E><D><L><E><N><A><L><K><A><V><I><N><D><K><S><Y><K><E><N><I><M><R><L><S><S><L><H><K><D><R><P><V><E><P><L><D><L><A><V><F><W><V><E><F><V><M><R><H><K><G><A><P><H><L><R><P><A><A><H><D><L><T><W><Y><Q><Y><H><S><L><D><V><I><G><F><L><L><A><V><V><L><T><V><A><F><I><T><F><K><C><C><A><Y><G><Y><R><K><C><L><G><K><K><G><R><V><K><K><A><H><K><S><K><T><H>
Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.<BOP>
P22309
P60371
KR106_HUMAN
Keratin-associated protein 18.6
Homo
<M><A><A><S><T><M><S><V><C><S><S><D><L><S><Y><G><S><R><V><C><L><P><G><S><C><D><S><C><S><D><S><W><Q><V><D><D><C><P><E><S><C><C><E><P><P><C><C><A><P><A><P><C><L><S><L><V><C><T><P><V><S><R><V><S><S><P><C><C><P><V><T><C><E><P><S><P><C><Q><S><G><C><T><S><S><C><T><P><S><C><C><Q><Q><S><S><C><Q><L><A><C><C><A><S><S><P><C><Q><Q><A><C><C><V><P><V><C><C><K><T><V><C><C><K><P><V><C><C><V><S><V><C><C><G><D><S><S><C><C><Q><Q><S><S><C><Q><S><A><C><C><T><S><S><P><C><Q><Q><A><C><C><V><P><V><C><C><K><P><V><C><S><G><I><S><S><S><C><C><Q><Q><S><S><C><V><S><C><V><S><S><P><C><C><Q><A><V><C><E><P><S><P><C><Q><S><G><C><T><S><S><C><T><P><S><C><C><Q><Q><S><S><C><Q><P><T><C><C><T><S><S><P><C><Q><Q><A><C><C><V><P><V><C><C><V><P><V><C><C><V><P><T><C><S><E><D><S><S><S><C><C><Q><Q><S><S><C><Q><P><A><C><C><T><S><S><P><C><Q><H><A><C><C><V><P><V><C><S><G><A><S><T><S><C><C><Q><Q><S><S><C><Q><P><A><C><C><T><A><S><C><C><R><S><S><S><S><V><S><L><L><C><H><P><V><C><K><S><T><C><C><V><P><V><P><S><C><G><A><S><A><S><S><C><Q><P><S><C><C><R><T><A><S><C><V><S><L><L><C><R><P><M><C><S><R><P><A><C><Y><S><L><C><S><G><Q><K><S><S><C>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
P60371
Q96N66
MBOA7_HUMAN
Membrane-bound O-acyltransferase domain-containing protein 7
Homo
<M><S><P><E><E><W><T><Y><L><V><V><L><L><I><S><I><P><I><G><F><L><F><K><K><A><G><P><G><L><K><R><W><G><A><A><A><V><G><L><G><L><T><L><F><T><C><G><P><H><T><L><H><S><L><V><T><I><L><G><T><W><A><L><I><Q><A><Q><P><C><S><C><H><A><L><A><L><A><W><T><F><S><Y><L><L><F><F><R><A><L><S><L><L><G><L><P><T><P><T><P><F><T><N><A><V><Q><L><L><L><T><L><K><L><V><S><L><A><S><E><V><Q><D><L><H><L><A><Q><R><K><E><M><A><S><G><F><S><K><G><P><T><L><G><L><L><P><D><V><P><S><L><M><E><T><L><S><Y><S><Y><C><Y><V><G><I><M><T><G><P><F><F><R><Y><R><T><Y><L><D><W><L><E><Q><P><F><P><G><A><V><P><S><L><R><P><L><L><R><R><A><W><P><A><P><L><F><G><L><L><F><L><L><S><S><H><L><F><P><L><E><A><V><R><E><D><A><F><Y><A><R><P><L><P><A><R><L><F><Y><M><I><P><V><F><F><A><F><R><M><R><F><Y><V><A><W><I><A><A><E><C><G><C><I><A><A><G><F><G><A><Y><P><V><A><A><K><A><R><A><G><G><G><P><T><L><Q><C><P><P><P><S><S><P><E><K><A><A><S><L><E><Y><D><Y><E><T><I><R><N><I><D><C><Y><S><T><D><F><C><V><R><V><R><D><G><M><R><Y><W><N><M><T><V><Q><W><W><L><A><Q><Y><I><Y><K><S><A><P><A><R><S><Y><V><L><R><S><A><W><T><M><L><L><S><A><Y><W><H><G><L><H><P><G><Y><Y><L><S><F><L><T><I><P><L><C><L><A><A><E><G><R><L><E><S><A><L><R><G><R><L><S><P><G><G><Q><K><A><W><D><W><V><H><W><F><L><K><M><R><A><Y><D><Y><M><C><M><G><F><V><L><L><S><L><A><D><T><L><R><Y><W><A><S><I><Y><F><C><I><H><F><L><A><L><A><A><L><G><L><G><L><A><L><G><G><G><S><P><S><R><R><K><A><A><S><Q><P><T><S><L><A><P><E><K><L><R><E><E>
Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle . Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell . In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation .<BOP>
Q96N66
O94927
HAUS5_HUMAN
HAUS augmin-like complex subunit 5
Homo
<M><E><L><A><Q><E><A><R><E><L><G><C><W><A><V><E><E><M><G><V><P><V><A><A><R><A><P><E><S><T><L><R><R><L><C><L><G><Q><G><A><D><I><W><A><Y><I><L><Q><H><V><H><S><Q><R><T><V><K><K><I><R><G><N><L><L><W><Y><G><H><Q><D><S><P><Q><V><R><R><K><L><E><L><E><A><A><V><T><R><L><R><A><E><I><Q><E><L><D><Q><S><L><E><L><M><E><R><D><T><E><A><Q><D><T><A><M><E><Q><A><R><Q><H><T><Q><D><T><Q><R><R><A><L><L><L><R><A><Q><A><G><A><M><R><R><Q><Q><H><T><L><R><D><P><M><Q><R><L><Q><N><Q><L><R><R><L><Q><D><M><E><R><K><A><K><V><D><V><T><F><G><S><L><T><S><A><A><L><G><L><E><P><V><V><L><R><D><V><R><T><A><C><T><L><R><A><Q><F><L><Q><N><L><L><L><P><Q><A><K><R><G><S><L><P><T><P><H><D><D><H><F><G><T><S><Y><Q><Q><W><L><S><S><V><E><T><L><L><T><N><H><P><P><G><H><V><L><A><A><L><E><H><L><A><A><E><R><E><A><E><I><R><S><L><C><S><G><D><G><L><G><D><T><E><I><S><R><P><Q><A><P><D><Q><S><D><S><S><Q><T><L><P><S><M><V><H><L><I><Q><E><G><W><R><T><V><G><V><L><V><S><Q><R><S><T><L><L><K><E><R><Q><V><L><T><Q><R><L><Q><G><L><V><E><E><V><E><R><R><V><L><G><S><S><E><R><Q><V><L><I><L><G><L><R><R><C><C><L><W><T><E><L><K><A><L><H><D><Q><S><Q><E><L><Q><D><A><A><G><H><R><Q><L><L><L><R><E><L><Q><A><K><Q><Q><R><I><L><H><W><R><Q><L><V><E><E><T><Q><E><Q><V><R><L><L><I><K><G><N><S><A><S><K><T><R><L><C><R><S><P><G><E><V><L><A><L><V><Q><R><K><V><V><P><T><F><E><A><V><A><P><Q><S><R><E><L><L><R><C><L><E><E><E><V><R><H><L><P><H><I><L><L><G><T><L><L><R><H><R><P><G><E><L><K><P><L><P><T><V><L><P><S><I><H><Q><L><H><P><A><S><P><R><G><S><S><F><I><A><L><S><H><K><L><G><L><P><P><G><K><A><S><E><L><L><L><P><A><A><A><S><L><R><Q><D><L><L><L><L><Q><D><Q><R><S><L><W><C><W><D><L><L><H><M><K><T><S><L><P><P><G><L><P><T><Q><E><L><L><Q><I><Q><A><S><Q><E><K><Q><Q><K><E><N><L><G><Q><A><L><K><R><L><E><K><L><L><K><Q><A><L><E><R><I><P><E><L><Q><G><I><V><G><D><W><W><E><Q><P><G><Q><A><A><L><S><E><E><L><C><Q><G><L><S><L><P><Q><W><R><L><R><W><V><Q><A><Q><G><A><L><Q><K><L><C><S>
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.<BOP>
O94927
A0A075B6L2
TVG11_HUMAN
Probable non-functional T cell receptor gamma variable 11
Homo
<M><P><L><V><V><A><V><I><F><F><S><L><W><V><F><A><L><G><Q><L><E><Q><P><E><I><S><I><S><R><P><A><N><K><S><A><H><I><S><W><K><A><S><I><Q><G><F><S><S><K><I><I><H><W><Y><W><Q><K><P><N><K><G><L><E><Y><L><L><H><V><F><L><T><I><S><A><Q><D><C><S><G><G><K><T><K><K><L><E><V><S><K><N><A><H><T><S><T><S><T><L><K><I><K><F><L><E><K><E><D><E><V><V><Y><H><C><A><C><W><I><R><H>
Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) gamma chain . Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair . Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLC
A0A075B6L2
P42772
CDN2B_HUMAN
p15-INK4b
Homo
<M><R><E><E><N><K><G><M><P><S><G><G><G><S><D><E><G><L><A><S><A><A><A><R><G><L><V><E><K><V><R><Q><L><L><E><A><G><A><D><P><N><G><V><N><R><F><G><R><R><A><I><Q><V><M><M><M><G><S><A><R><V><A><E><L><L><L><L><H><G><A><E><P><N><C><A><D><P><A><T><L><T><R><P><V><H><D><A><A><R><E><G><F><L><D><T><L><V><V><L><H><R><A><G><A><R><L><D><V><R><D><A><W><G><R><L><P><V><D><L><A><E><E><R><G><H><R><D><V><A><G><Y><L><R><T><A><T><G><D>
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.<BOP>
P42772
Q9NRR3
C42S2_HUMAN
Small effector of CDC42 protein 2
Homo
<M><S><E><F><W><L><C><F><N><C><C><I><A><E><Q><P><Q><P><K><R><R><R><R><I><D><R><S><M><I><G><E><P><T><N><F><V><H><T><A><H><V><G><S><G><D><L><F><S><G><M><N><S><V><S><S><I><Q><N><Q><M><Q><S><K><G><G><Y><G><G><G><M><P><A><N><V><Q><M><Q><L><V><D><T><K><A><G>
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.<BOP>
Q9NRR3
O75771
RA51D_HUMAN
TRAD
Homo
<M><G><V><L><R><V><G><L><C><P><G><L><T><E><E><M><I><Q><L><L><R><S><H><R><I><K><T><V><V><D><L><V><S><A><D><L><E><E><V><A><Q><K><C><G><L><S><Y><K><A><L><V><A><L><R><R><V><L><L><A><Q><F><S><A><F><P><V><N><G><A><D><L><Y><E><E><L><K><T><S><T><A><I><L><S><T><G><I><G><S><L><D><K><L><L><D><A><G><L><Y><T><G><E><V><T><E><I><V><G><G><P><G><S><G><K><T><Q><V><C><L><C><M><A><A><N><V><A><H><G><L><Q><Q><N><V><L><Y><V><D><S><N><G><G><L><T><A><S><R><L><L><Q><L><L><Q><A><K><T><Q><D><E><E><E><Q><A><E><A><L><R><R><I><Q><V><V><H><A><F><D><I><F><Q><M><L><D><V><L><Q><E><L><R><G><T><V><A><Q><Q><V><T><G><S><S><G><T><V><K><V><V><V><V><D><S><V><T><A><V><V><S><P><L><L><G><G><Q><Q><R><E><G><L><A><L><M><M><Q><L><A><R><E><L><K><T><L><A><R><D><L><G><M><A><V><V><V><T><N><H><I><T><R><D><R><D><S><G><R><L><K><P><A><L><G><R><S><W><S><F><V><P><S><T><R><I><L><L><D><T><I><E><G><A><G><A><S><G><G><R><R><M><A><C><L><A><K><S><S><R><Q><P><T><G><F><Q><E><M><V><D><I><G><T><W><G><T><S><E><Q><S><A><T><L><Q><G><D><Q><T>
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.<BOP>
O75771
Q9UGF6
OR5V1_HUMAN
Olfactory receptor OR6-26
Homo
<M><E><R><K><N><Q><T><A><I><T><E><F><I><I><L><G><F><S><N><L><N><E><L><Q><F><L><L><F><T><I><F><F><L><T><Y><F><C><T><L><G><G><N><I><L><I><I><L><T><T><V><T><D><P><H><L><H><T><P><M><Y><Y><F><L><G><N><L><A><F><I><D><I><C><Y><T><T><S><N><V><P><Q><M><M><V><H><L><L><S><K><K><K><S><I><S><Y><V><G><C><V><V><Q><L><F><A><F><V><F><F><V><G><S><E><C><L><L><L><A><A><M><A><Y><D><R><Y><I><A><I><C><N><P><L><R><Y><S><V><I><L><S><K><V><L><C><N><Q><L><A><A><S><C><W><A><A><G><F><L><N><S><V><V><H><T><V><L><T><F><C><L><P><F><C><G><N><N><Q><I><N><Y><F><F><C><D><I><P><P><L><L><I><L><S><C><G><N><T><S><V><N><E><L><A><L><L><S><T><G><V><F><I><G><W><T><P><F><L><C><I><V><L><S><Y><I><C><I><I><S><T><I><L><R><I><Q><S><S><E><G><R><R><K><A><F><S><T><C><A><S><H><L><A><I><V><F><L><F><Y><G><S><A><I><F><T><Y><V><R><P><I><S><T><Y><S><L><K><K><D><R><L><V><S><V><L><Y><S><V><V><T><P><M><L><N><P><I><I><Y><T><L><R><N><K><D><I><K><E><A><V><K><T><I><G><S><K><W><Q><P><P><I><S><S><L><D><S><K><L><T><Y>
Odorant receptor.<BOP>
Q9UGF6
Q6UXF1
TM108_HUMAN
Retrolinkin
Homo
<M><K><R><S><L><Q><A><L><Y><C><Q><L><L><S><F><L><L><I><L><A><L><T><E><A><L><A><F><A><I><Q><E><P><S><P><R><E><S><L><Q><V><L><P><S><G><T><P><P><G><T><M><V><T><A><P><H><S><S><T><R><H><T><S><V><V><M><L><T><P><N><P><D><G><P><P><S><Q><A><A><A><P><M><A><T><P><T><P><R><A><E><G><H><P><P><T><H><T><I><S><T><I><A><A><T><V><T><A><P><H><S><E><S><S><L><S><T><G><P><A><P><A><A><M><A><T><T><S><S><K><P><E><G><R><P><R><G><Q><A><A><P><T><I><L><L><T><K><P><P><G><A><T><S><R><P><T><T><A><P><P><R><T><T><T><R><R><P><P><R><P><P><G><S><S><R><K><G><A><G><N><S><S><R><P><V><P><P><A><P><G><G><H><S><R><S><K><E><G><Q><R><G><R><N><P><S><S><T><P><L><G><Q><K><R><P><L><G><K><I><F><Q><I><Y><K><G><N><F><T><G><S><V><E><P><E><P><S><T><L><T><P><R><T><P><L><W><G><Y><S><S><S><P><Q><P><Q><T><V><A><A><T><T><V><P><S><N><T><S><W><A><P><T><T><T><S><L><G><P><A><K><D><K><P><G><L><R><R><A><A><Q><G><G><G><S><T><F><T><S><Q><G><G><T><P><D><A><T><A><A><S><G><A><P><V><S><P><Q><A><A><P><V><P><S><Q><R><P><H><H><G><D><P><Q><D><G><P><S><H><S><D><S><W><L><T><V><T><P><G><T><S><R><P><L><S><T><S><S><G><V><F><T><A><A><T><G><P><T><P><A><A><F><D><T><S><V><S><A><P><S><Q><G><I><P><Q><G><A><S><T><T><P><Q><A><P><T><H><P><S><R><V><S><E><S><T><I><S><G><A><K><E><E><T><V><A><T><L><T><M><T><D><R><V><P><S><P><L><S><T><V><V><S><T><A><T><G><N><F><L><N><R><L><V><P><A><G><T><W><K><P><G><T><A><G><N><I><S><H><V><A><E><G><D><K><P><Q><H><R><A><T><I><C><L><S><K><M><D><I><A><W><V><I><L><A><I><S><V><P><I><S><S><C><S><V><L><L><T><V><C><C><M><K><R><K><K><K><T><A><N><P><E><N><N><L><S><Y><W><N><N><T><I><T><M><D><Y><F><N><R><H><A><V><E><L><P><R><E><I><Q><S><L><E><T><S><E><D><Q><L><S><E><P><R><S><P><A><N><G><D><Y><R><D><T><G><M><V><L><V><N><P><F><C><Q><E><T><L><F><V><G><N><D><Q><V><S><E><I>
Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.<BOP>
Q6UXF1
O96033
MOC2A_HUMAN
Sulfur carrier protein MOCS2A
Homo
<M><V><P><L><C><Q><V><E><V><L><Y><F><A><K><S><A><E><I><T><G><V><R><S><E><T><I><S><V><P><Q><E><I><K><A><L><Q><L><W><K><E><I><E><T><R><H><P><G><L><A><D><V><R><N><Q><I><I><F><A><V><R><Q><E><Y><V><E><L><G><D><Q><L><L><V><L><Q><P><G><D><E><I><A><V><I><P><P><I><S><G><G>
Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.<BOP>
O96033
Q8NGE3
O10P1_HUMAN
Olfactory receptor OR12-7
Homo
<M><A><G><E><N><H><T><T><L><P><E><F><L><L><L><G><F><S><D><L><K><A><L><Q><G><P><L><F><W><V><V><L><L><V><Y><L><V><T><L><L><G><N><S><L><I><I><L><L><T><Q><V><S><P><A><L><H><S><P><M><Y><F><F><L><R><Q><L><S><V><V><E><L><F><Y><T><T><D><I><V><P><R><T><L><A><N><L><G><S><P><H><P><Q><A><I><S><F><Q><G><C><A><A><Q><M><Y><V><F><I><V><L><G><I><S><E><C><C><L><L><T><A><M><A><Y><D><R><Y><V><A><I><C><Q><P><L><R><Y><S><T><L><L><S><P><R><A><C><M><A><M><V><G><T><S><W><L><T><G><I><I><T><A><T><T><H><A><S><L><I><F><S><L><P><F><R><S><H><P><I><I><P><H><F><L><C><D><I><L><P><V><L><R><L><A><S><A><G><K><H><R><S><E><I><S><V><M><T><A><T><I><V><F><I><M><I><P><F><S><L><I><V><T><S><Y><I><R><I><L><G><A><I><L><A><M><A><S><T><Q><S><R><R><K><V><F><S><T><C><S><S><H><L><L><V><V><S><L><F><F><G><T><A><S><I><T><Y><I><R><P><Q><A><G><S><S><V><T><T><D><R><V><L><S><L><F><Y><T><V><I><T><P><M><L><N><P><I><I><Y><T><L><R><N><K><D><V><R><R><A><L><R><H><L><V><K><R><Q><R><P><S><P>
Odorant receptor.<BOP>
Q8NGE3
Q86WT1
TT30A_HUMAN
Tetratricopeptide repeat protein 30A
Homo
<M><A><G><L><S><G><A><Q><I><P><D><G><E><F><T><A><L><V><Y><R><L><I><R><D><A><R><Y><A><E><A><V><Q><L><L><G><R><E><L><Q><R><S><P><R><S><R><A><G><L><S><L><L><G><Y><C><Y><Y><R><L><Q><E><F><A><L><A><A><E><C><Y><E><Q><L><G><Q><L><H><P><E><L><E><Q><Y><R><L><Y><Q><A><Q><A><L><Y><K><A><C><L><Y><P><E><A><T><R><V><A><F><L><L><L><D><N><P><A><Y><H><S><R><V><L><R><L><Q><A><A><I><K><Y><S><E><G><D><L><P><G><S><R><S><L><V><E><Q><L><L><S><G><E><G><G><E><E><S><G><G><D><N><E><T><D><G><Q><V><N><L><G><C><L><L><Y><K><E><G><Q><Y><E><A><A><C><S><K><F><S><A><T><L><Q><A><S><G><Y><Q><P><D><L><S><Y><N><L><A><L><A><Y><Y><S><S><R><Q><Y><A><S><A><L><K><H><I><A><E><I><I><E><R><G><I><R><Q><H><P><E><L><G><V><G><M><T><T><E><G><F><D><V><R><S><V><G><N><T><L><V><L><H><Q><T><A><L><V><E><A><F><N><L><K><A><A><I><E><Y><Q><L><R><N><Y><E><V><A><Q><E><T><L><T><D><M><P><P><R><A><E><E><E><L><D><P><V><T><L><H><N><Q><A><L><M><N><M><D><A><R><P><T><E><G><F><E><K><L><Q><F><L><L><Q><Q><N><P><F><P><P><E><T><F><G><N><L><L><L><L><Y><C><K><Y><E><Y><F><D><L><A><A><D><V><L><A><E><N><A><H><L><T><Y><K><F><L><T><P><Y><L><Y><D><F><L><D><A><L><I><T><C><Q><T><A><P><E><E><A><F><I><K><L><D><G><L><A><G><M><L><T><E><Q><L><R><R><L><T><K><Q><V><Q><E><A><R><H><N><R><D><D><E><A><I><K><K><A><V><N><E><Y><D><E><T><M><E><K><Y><I><P><V><L><M><A><Q><A><K><I><Y><W><N><L><E><N><Y><P><M><V><E><K><V><F><R><K><S><V><E><F><C><N><D><H><D><V><W><K><L><N><V><A><H><V><L><F><M><Q><E><N><K><Y><K><E><A><I><G><F><Y><E><P><I><V><K><K><H><Y><D><N><I><L><N><V><S><A><I><V><L><A><N><L><C><V><S><Y><I><M><T><S><Q><N><E><E><A><E><E><L><M><R><K><I><E><K><E><E><E><Q><L><S><Y><D><D><P><N><R><K><M><Y><H><L><C><I><V><N><L><V><I><G><T><L><Y><C><A><K><G><N><Y><E><F><G><I><S><R><V><I><K><S><L><E><P><Y><N><K><K><L><G><T><D><T><W><Y><Y><A><K><R><C><F><L><S><L><L><E><N><M><S><K><H><M><I><V><I><H><D><S><V><I><Q><E><C><V><Q><F><L><G><H><C><E><L><Y><G><T><N><I><P><A><V><I><E><Q><P><L><E><E><E><R><M><H><V><G><K><N><T><V><T><D><E><S><R><Q><L><K><A><L><I><Y><E><I><I><G><W><N><K>
Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.<BOP>
Q86WT1
P04424
ARLY_HUMAN
Arginosuccinase
Homo
<M><A><S><E><S><G><K><L><W><G><G><R><F><V><G><A><V><D><P><I><M><E><K><F><N><A><S><I><A><Y><D><R><H><L><W><E><V><D><V><Q><G><S><K><A><Y><S><R><G><L><E><K><A><G><L><L><T><K><A><E><M><D><Q><I><L><H><G><L><D><K><V><A><E><E><W><A><Q><G><T><F><K><L><N><S><N><D><E><D><I><H><T><A><N><E><R><R><L><K><E><L><I><G><A><T><A><G><K><L><H><T><G><R><S><R><N><D><Q><V><V><T><D><L><R><L><W><M><R><Q><T><C><S><T><L><S><G><L><L><W><E><L><I><R><T><M><V><D><R><A><E><A><E><R><D><V><L><F><P><G><Y><T><H><L><Q><R><A><Q><P><I><R><W><S><H><W><I><L><S><H><A><V><A><L><T><R><D><S><E><R><L><L><E><V><R><K><R><I><N><V><L><P><L><G><S><G><A><I><A><G><N><P><L><G><V><D><R><E><L><L><R><A><E><L><N><F><G><A><I><T><L><N><S><M><D><A><T><S><E><R><D><F><V><A><E><F><L><F><W><A><S><L><C><M><T><H><L><S><R><M><A><E><D><L><I><L><Y><C><T><K><E><F><S><F><V><Q><L><S><D><A><Y><S><T><G><S><S><L><M><P><Q><K><K><N><P><D><S><L><E><L><I><R><S><K><A><G><R><V><F><G><R><C><A><G><L><L><M><T><L><K><G><L><P><S><T><Y><N><K><D><L><Q><E><D><K><E><A><V><F><E><V><S><D><T><M><S><A><V><L><Q><V><A><T><G><V><I><S><T><L><Q><I><H><Q><E><N><M><G><Q><A><L><S><P><D><M><L><A><T><D><L><A><Y><Y><L><V><R><K><G><M><P><F><R><Q><A><H><E><A><S><G><K><A><V><F><M><A><E><T><K><G><V><A><L><N><Q><L><S><L><Q><E><L><Q><T><I><S><P><L><F><S><G><D><V><I><C><V><W><D><Y><G><H><S><V><E><Q><Y><G><A><L><G><G><T><A><R><S><S><V><D><W><Q><I><R><Q><V><R><A><L><L><Q><A><Q><Q><A>
Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues . Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway .<BOP>
P04424
Q96EP5
DAZP1_HUMAN
Deleted in azoospermia-associated protein 1
Homo
<M><N><N><S><G><A><D><E><I><G><K><L><F><V><G><G><L><D><W><S><T><T><Q><E><T><L><R><S><Y><F><S><Q><Y><G><E><V><V><D><C><V><I><M><K><D><K><T><T><N><Q><S><R><G><F><G><F><V><K><F><K><D><P><N><C><V><G><T><V><L><A><S><R><P><H><T><L><D><G><R><N><I><D><P><K><P><C><T><P><R><G><M><Q><P><E><R><T><R><P><K><E><G><W><Q><K><G><P><R><S><D><N><S><K><S><N><K><I><F><V><G><G><I><P><H><N><C><G><E><T><E><L><R><E><Y><F><K><K><F><G><V><V><T><E><V><V><M><I><Y><D><A><E><K><Q><R><P><R><G><F><G><F><I><T><F><E><D><E><Q><S><V><D><Q><A><V><N><M><H><F><H><D><I><M><G><K><K><V><E><V><K><R><A><E><P><R><D><S><K><S><Q><A><P><G><Q><P><G><A><S><Q><W><G><S><R><V><V><P><N><A><A><N><G><W><A><G><Q><P><P><P><T><W><Q><Q><G><Y><G><P><Q><G><M><W><V><P><A><G><Q><A><I><G><G><Y><G><P><P><P><A><G><R><G><A><P><P><P><P><P><P><F><T><S><Y><I><V><S><T><P><P><G><G><F><P><P><P><Q><G><F><P><Q><G><Y><G><A><P><P><Q><F><S><F><G><Y><G><P><P><P><P><P><P><D><Q><F><A><P><P><G><V><P><P><P><P><A><T><P><G><A><A><P><L><A><F><P><P><P><P><S><Q><A><A><P><D><M><S><K><P><P><T><A><Q><P><D><F><P><Y><G><Q><Y><A><G><Y><G><Q><D><L><S><G><F><G><Q><G><F><S><D><P><S><Q><Q><P><P><S><Y><G><G><P><S><V><P><G><S><G><G><P><P><A><G><G><S><G><F><G><R><G><Q><N><H><N><V><Q><G><F><H><P><Y><R><R>
RNA-binding protein, which may be required during spermatogenesis.<BOP>
Q96EP5
Q9H1P3
OSBL2_HUMAN
Oxysterol-binding protein-related protein 2
Homo
<M><N><G><E><E><E><F><F><D><A><V><T><G><F><D><S><D><N><S><S><G><E><F><S><E><A><N><Q><K><V><T><G><M><I><D><L><D><T><S><K><N><N><R><I><G><K><T><G><E><R><P><S><Q><E><N><G><I><Q><K><H><R><T><S><L><P><A><P><M><F><S><R><S><D><F><S><V><W><T><I><L><K><K><C><V><G><L><E><L><S><K><I><T><M><P><I><A><F><N><E><P><L><S><F><L><Q><R><I><T><E><Y><M><E><H><V><Y><L><I><H><R><A><S><C><Q><P><Q><P><L><E><R><M><Q><S><V><A><A><F><A><V><S><A><V><A><S><Q><W><E><R><T><G><K><P><F><N><P><L><L><G><E><T><Y><E><L><I><R><E><D><L><G><F><R><F><I><S><E><Q><V><S><H><H><P><P><I><S><A><F><H><S><E><G><L><N><H><D><F><L><F><H><G><S><I><Y><P><K><L><K><F><W><G><K><S><V><E><A><E><P><R><G><T><I><T><L><E><L><L><K><H><N><E><A><Y><T><W><T><N><P><T><C><C><V><H><N><V><I><I><G><K><L><W><I><E><Q><Y><G><T><V><E><I><L><N><H><R><T><G><H><K><C><V><L><H><F><K><P><C><G><L><F><G><K><E><L><H><K><V><E><G><H><I><Q><D><K><N><K><K><K><L><F><M><I><Y><G><K><W><T><E><C><L><W><G><I><D><P><V><S><Y><E><S><F><K><K><Q><E><R><R><G><D><H><L><R><K><A><K><L><D><E><D><S><G><K><A><D><S><D><V><A><D><D><V><P><V><A><Q><E><T><V><Q><V><I><P><G><S><K><L><L><W><R><I><N><T><R><P><P><N><S><A><Q><M><Y><N><F><T><S><F><T><V><S><L><N><E><L><E><T><G><M><E><K><T><L><P><P><T><D><C><R><L><R><P><D><I><R><G><M><E><N><G><N><M><D><L><A><S><Q><E><K><E><R><L><E><E><K><Q><R><E><A><R><R><E><R><A><K><E><E><A><E><W><Q><T><R><W><F><Y><P><G><N><N><P><Y><T><G><T><P><D><W><L><Y><A><G><D><Y><F><E><R><N><F><S><D><C><P><D><I><Y>
Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane . Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate . Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate . Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro) .<BOP>
Q9H1P3
Q13889
TF2H3_HUMAN
TFIIH basal transcription factor complex p34 subunit
Homo
<M><V><S><D><E><D><E><L><N><L><L><V><I><V><V><D><A><N><P><I><W><W><G><K><Q><A><L><K><E><S><Q><F><T><L><S><K><C><I><D><A><V><M><V><L><G><N><S><H><L><F><M><N><R><S><N><K><L><A><V><I><A><S><H><I><Q><E><S><R><F><L><Y><P><G><K><N><G><R><L><G><D><F><F><G><D><P><G><N><P><P><E><F><N><P><S><G><S><K><D><G><K><Y><E><L><L><T><S><A><N><E><V><I><V><E><E><I><K><D><L><M><T><K><S><D><I><K><G><Q><H><T><E><T><L><L><A><G><S><L><A><K><A><L><C><Y><I><H><R><M><N><K><E><V><K><D><N><Q><E><M><K><S><R><I><L><V><I><K><A><A><E><D><S><A><L><Q><Y><M><N><F><M><N><V><I><F><A><A><Q><K><Q><N><I><L><I><D><A><C><V><L><D><S><D><S><G><L><L><Q><Q><A><C><D><I><T><G><G><L><Y><L><K><V><P><Q><M><P><S><L><L><Q><Y><L><L><W><V><F><L><P><D><Q><D><Q><R><S><Q><L><I><L><P><P><P><V><H><V><D><Y><R><A><A><C><F><C><H><R><N><L><I><E><I><G><Y><V><C><S><V><C><L><S><I><F><C><N><F><S><P><I><C><T><T><C><E><T><A><F><K><I><S><L><P><P><V><L><K><A><K><K><K><K><L><K><V><S><A>
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.<BOP>
Q13889
P78318
IGBP1_HUMAN
Renal carcinoma antigen NY-REN-16
Homo
<M><A><A><E><D><E><L><Q><L><P><R><L><P><E><L><F><E><T><G><R><Q><L><L><D><E><V><E><V><A><T><E><P><A><G><S><R><I><V><Q><E><K><V><F><K><G><L><D><L><L><E><K><A><A><E><M><L><S><Q><L><D><L><F><S><R><N><E><D><L><E><E><I><A><S><T><D><L><K><Y><L><L><V><P><A><F><Q><G><A><L><T><M><K><Q><V><N><P><S><K><R><L><D><H><L><Q><R><A><R><E><H><F><I><N><Y><L><T><Q><C><H><C><Y><H><V><A><E><F><E><L><P><K><T><M><N><N><S><A><E><N><H><T><A><N><S><S><M><A><Y><P><S><L><V><A><M><A><S><Q><R><Q><A><K><I><Q><R><Y><K><Q><K><K><E><L><E><H><R><L><S><A><M><K><S><A><V><E><S><G><Q><A><D><D><E><R><V><R><E><Y><Y><L><L><H><L><Q><R><W><I><D><I><S><L><E><E><I><E><S><I><D><Q><E><I><K><I><L><R><E><R><D><S><S><R><E><A><S><T><S><N><S><S><R><Q><E><R><P><P><V><K><P><F><I><L><T><R><N><M><A><Q><A><K><V><F><G><A><G><Y><P><S><L><P><T><M><T><V><S><D><W><Y><E><Q><H><R><K><Y><G><A><L><P><D><Q><G><I><A><K><A><A><P><E><E><F><R><K><A><A><Q><Q><Q><E><E><Q><E><E><K><E><E><E><D><D><E><Q><T><L><H><R><A><R><E><W><D><D><W><K><D><T><H><P><R><G><Y><G><N><R><Q><N><M><G>
Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.<BOP>
P78318
P51800
CLCKA_HUMAN
ClC-K1
Homo
<M><E><E><L><V><G><L><R><E><G><F><S><G><D><P><V><T><L><Q><E><L><W><G><P><C><P><H><I><R><R><A><I><Q><G><G><L><E><W><L><K><Q><K><V><F><R><L><G><E><D><W><Y><F><L><M><T><L><G><V><L><M><A><L><V><S><Y><A><M><N><F><A><I><G><C><V><V><R><A><H><Q><W><L><Y><R><E><I><G><D><S><H><L><L><R><Y><L><S><W><T><V><Y><P><V><A><L><V><S><F><S><S><G><F><S><Q><S><I><T><P><S><S><G><G><S><G><I><P><E><L><K><T><M><L><A><G><V><I><L><E><D><Y><L><D><I><K><N><F><G><A><K><V><V><G><L><S><C><T><L><A><T><G><S><T><L><F><L><G><K><V><G><P><F><V><H><L><S><V><M><I><A><A><Y><L><G><R><V><R><T><T><T><I><G><E><P><E><N><K><S><K><Q><N><E><M><L><V><A><A><A><A><V><G><V><A><T><V><F><A><A><P><F><S><G><V><L><F><S><I><E><V><M><S><S><H><F><S><V><R><D><Y><W><R><G><F><F><A><A><T><C><G><A><F><I><F><R><L><L><A><V><F><N><S><E><Q><E><T><I><T><S><L><Y><K><T><S><F><R><V><D><V><P><F><D><L><P><E><I><F><F><F><V><A><L><G><G><I><C><G><V><L><S><C><A><Y><L><F><C><Q><R><T><F><L><S><F><I><K><T><N><R><Y><S><S><K><L><L><A><T><S><K><P><V><Y><S><A><L><A><T><L><L><L><A><S><I><T><Y><P><P><G><V><G><H><F><L><A><S><R><L><S><M><K><Q><H><L><D><S><L><F><D><N><H><S><W><A><L><M><T><Q><N><S><S><P><P><W><P><E><E><L><D><P><Q><H><L><W><W><E><W><Y><H><P><R><F><T><I><F><G><T><L><A><F><F><L><V><M><K><F><W><M><L><I><L><A><T><T><I><P><M><P><A><G><Y><F><M><P><I><F><I><L><G><A><A><I><G><R><L><L><G><E><A><L><A><V><A><F><P><E><G><I><V><T><G><G><V><T><N><P><I><M><P><G><G><Y><A><L><A><G><A><A><A><F><S><G><A><V><T><H><T><I><S><T><A><L><L><A><F><E><L><T><G><Q><I><V><H><A><L><P><V><L><M><A><V><L><A><A><N><A><I><A><Q><S><C><Q><P><S><F><Y><D><G><T><I><I><V><K><K><L><P><Y><L><P><R><I><L><G><R><N><I><G><S><H><H><V><R><V><E><H><F><M><N><H><S><I><T><T><L><A><K><D><T><P><L><E><E><V><V><K><V><V><T><S><T><D><V><T><E><Y><P><L><V><E><S><T><E><S><Q><I><L><V><G><I><V><Q><R><A><Q><L><V><Q><A><L><Q><A><E><P><P><S><R><A><P><G><H><Q><Q><C><L><Q><D><I><L><A><R><G><C><P><T><E><P><V><T><L><T><L><F><S><E><T><T><L><H><Q><A><Q><N><L><F><K><L><L><N><L><Q><S><L><F><V><T><S><R><G><R><A><V><G><C><V><S><W><V><E><M><K><K><A><I><S><N><L><T><N><P><P><A><P><K>
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.<BOP>
P51800
O60381
HBP1_HUMAN
High mobility group box transcription factor 1
Homo
<M><V><W><E><V><K><T><N><Q><M><P><N><A><V><Q><K><L><L><L><V><M><D><K><R><A><S><G><M><N><D><S><L><E><L><L><Q><C><N><E><N><L><P><S><S><P><G><Y><N><S><C><D><E><H><M><E><L><D><D><L><P><E><L><Q><A><V><Q><S><D><P><T><Q><S><G><M><Y><Q><L><S><S><D><V><S><H><Q><E><Y><P><R><S><S><W><N><Q><N><T><S><D><I><P><E><T><T><Y><R><E><N><E><V><D><W><L><T><E><L><A><N><I><A><T><S><P><Q><S><P><L><M><Q><C><S><F><Y><N><R><S><S><P><V><H><I><I><A><T><S><K><S><L><H><S><Y><A><R><P><P><P><V><S><S><S><S><K><S><E><P><A><F><P><H><H><H><W><K><E><E><T><P><V><R><H><E><R><A><N><S><E><S><E><S><G><I><F><C><M><S><S><L><S><D><D><D><D><L><G><W><C><N><S><W><P><S><T><V><W><H><C><F><L><K><G><T><R><L><C><F><H><K><G><S><N><K><E><W><Q><D><V><E><D><F><A><R><A><E><G><C><D><N><E><E><D><L><Q><M><G><I><H><K><G><Y><G><S><D><G><L><K><L><L><S><H><E><E><S><V><S><F><G><E><S><V><L><K><L><T><F><D><P><G><T><V><E><D><G><L><L><T><V><E><C><K><L><D><H><P><F><Y><V><K><N><K><G><W><S><S><F><Y><P><S><L><T><V><V><Q><H><G><I><P><C><C><E><V><H><I><G><D><V><C><L><P><P><G><H><P><D><A><I><N><F><D><D><S><G><V><F><D><T><F><K><S><Y><D><F><T><P><M><D><S><S><A><V><Y><V><L><S><S><M><A><R><Q><R><R><A><S><L><S><C><G><G><P><G><G><Q><D><F><A><R><S><G><F><S><K><N><C><G><S><P><G><S><S><Q><L><S><S><N><S><L><Y><A><K><A><V><K><N><H><S><S><G><T><V><S><A><T><S><P><N><K><C><K><R><P><M><N><A><F><M><L><F><A><K><K><Y><R><V><E><Y><T><Q><M><Y><P><G><K><D><N><R><A><I><S><V><I><L><G><D><R><W><K><K><M><K><N><E><E><R><R><M><Y><T><L><E><A><K><A><L><A><E><E><Q><K><R><L><N><P><D><C><W><K><R><K><R><T><N><S><G><S><Q><Q><H>
Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.<BOP>
O60381
P01814
HV270_HUMAN
Ig heavy chain V-II region SESS
Homo
<M><D><I><L><C><S><T><L><L><L><L><T><V><P><S><W><V><L><S><Q><V><T><L><R><E><S><G><P><A><L><V><K><P><T><Q><T><L><T><L><T><C><T><F><S><G><F><S><L><S><T><S><G><M><C><V><S><W><I><R><Q><P><P><G><K><A><L><E><W><L><A><L><I><D><W><D><D><D><K><Y><Y><S><T><S><L><K><T><R><L><T><I><S><K><D><T><S><K><N><Q><V><V><L><T><M><T><N><M><D><P><V><D><T><A><T><Y><Y><C><A><R><I>
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P01814
P32189
GLPK_HUMAN
ATP:glycerol 3-phosphotransferase
Homo
<M><A><A><S><K><K><A><V><L><G><P><L><V><G><A><V><D><Q><G><T><S><S><T><R><F><L><V><F><N><S><K><T><A><E><L><L><S><H><H><Q><V><E><I><K><Q><E><F><P><R><E><G><W><V><E><Q><D><P><K><E><I><L><H><S><V><Y><E><C><I><E><K><T><C><E><K><L><G><Q><L><N><I><D><I><S><N><I><K><A><I><G><V><S><N><Q><R><E><T><T><V><V><W><D><K><I><T><G><E><P><L><Y><N><A><V><V><W><L><D><L><R><T><Q><S><T><V><E><S><L><S><K><R><I><P><G><N><N><N><F><V><K><S><K><T><G><L><P><L><S><T><Y><F><S><A><V><K><L><R><W><L><L><D><N><V><R><K><V><Q><K><A><V><E><E><K><R><A><L><F><G><T><I><D><S><W><L><I><W><S><L><T><G><G><V><N><G><G><V><H><C><T><D><V><T><N><A><S><R><T><M><L><F><N><I><H><S><L><E><W><D><K><Q><L><C><E><F><F><G><I><P><M><E><I><L><P><N><V><R><S><S><S><E><I><Y><G><L><M><K><I><S><H><S><V><K><A><G><A><L><E><G><V><P><I><S><G><C><L><G><D><Q><S><A><A><L><V><G><Q><M><C><F><Q><I><G><Q><A><K><N><T><Y><G><T><G><C><F><L><L><C><N><T><G><H><K><C><V><F><S><D><H><G><L><L><T><T><V><A><Y><K><L><G><R><D><K><P><V><Y><Y><A><L><E><G><S><V><A><I><A><G><A><V><I><R><W><L><R><D><N><L><G><I><I><K><T><S><E><E><I><E><K><L><A><K><E><V><G><T><S><Y><G><C><Y><F><V><P><A><F><S><G><L><Y><A><P><Y><W><E><P><S><A><R><G><I><I><C><G><L><T><Q><F><T><N><K><C><H><I><A><F><A><A><L><E><A><V><C><F><Q><T><R><E><I><L><D><A><M><N><R><D><C><G><I><P><L><S><H><L><Q><V><D><G><G><M><T><S><N><K><I><L><M><Q><L><Q><A><D><I><L><Y><I><P><V><V><K><P><S><M><P><E><T><T><A><L><G><A><A><M><A><A><G><A><A><E><G><V><G><V><W><S><L><E><P><E><D><L><S><A><V><T><M><E><R><F><E><P><Q><I><N><A><E><E><S><E><I><R><Y><S><T><W><K><K><A><V><M><K><S><M><G><W><V><T><T><Q><S><P><E><S><G><D><P><S><I><F><C><S><L><P><L><G><F><F><I><V><S><S><M><V><M><L><I><G><A><R><Y><I><S><G><I><P>
Key enzyme in the regulation of glycerol uptake and metabolism.<BOP>
P32189
Q9BQ16
TICN3_HUMAN
SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3
Homo
<M><L><K><V><S><A><V><L><C><V><C><A><A><A><W><C><S><Q><S><L><A><A><A><A><A><V><A><A><A><G><G><R><S><D><G><G><N><F><L><D><D><K><Q><W><L><T><T><I><S><Q><Y><D><K><E><V><G><Q><W><N><K><F><R><D><E><V><E><D><D><Y><F><R><T><W><S><P><G><K><P><F><D><Q><A><L><D><P><A><K><D><P><C><L><K><M><K><C><S><R><H><K><V><C><I><A><Q><D><S><Q><T><A><V><C><I><S><H><R><R><L><T><H><R><M><K><E><A><G><V><D><H><R><Q><W><R><G><P><I><L><S><T><C><K><Q><C><P><V><V><Y><P><S><P><V><C><G><S><D><G><H><T><Y><S><F><Q><C><K><L><E><Y><Q><A><C><V><L><G><K><Q><I><S><V><K><C><E><G><H><C><P><C><P><S><D><K><P><T><S><T><S><R><N><V><K><R><A><C><S><D><L><E><F><R><E><V><A><N><R><L><R><D><W><F><K><A><L><H><E><S><G><S><Q><N><K><K><T><K><T><L><L><R><P><E><R><S><R><F><D><T><S><I><L><P><I><C><K><D><S><L><G><W><M><F><N><R><L><D><T><N><Y><D><L><L><L><D><Q><S><E><L><R><S><I><Y><L><D><K><N><E><Q><C><T><K><A><F><F><N><S><C><D><T><Y><K><D><S><L><I><S><N><N><E><W><C><Y><C><F><Q><R><Q><Q><D><P><P><C><Q><T><E><L><S><N><I><Q><K><R><Q><G><V><K><K><L><L><G><Q><Y><I><P><L><C><D><E><D><G><Y><Y><K><P><T><Q><C><H><G><S><V><G><Q><C><W><C><V><D><R><Y><G><N><E><V><M><G><S><R><I><N><G><V><A><D><C><A><I><D><F><E><I><S><G><D><F><A><S><G><D><F><H><E><W><T><D><D><E><D><D><E><D><D><I><M><N><D><E><D><E><I><E><D><D><D><E><D><E><G><D><D><D><D><G><G><D><D><H><D><V><Y><I>
May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.<BOP>
Q9BQ16
Q16626
MEA1_HUMAN
Male-enhanced antigen 1
Homo
<M><G><P><E><R><H><L><S><G><A><P><A><R><M><A><T><V><V><L><G><G><D><T><M><G><P><E><R><I><F><P><N><Q><T><E><E><L><G><H><Q><G><P><S><E><G><T><G><D><W><S><S><E><E><P><E><E><E><Q><E><E><T><G><S><G><P><A><G><Y><S><Y><Q><P><L><N><Q><D><P><E><Q><E><E><V><E><L><A><P><V><G><D><G><D><V><V><A><D><I><Q><D><R><I><Q><A><L><G><L><H><L><P><D><P><P><L><E><S><E><D><E><D><E><E><G><A><T><A><L><N><N><H><S><S><I><P><M><D><P><E><H><V><E><L><V><K><R><T><M><A><G><V><S><L><P><A><P><G><V><P><A><W><A><R><E><I><S><D><A><Q><W><E><D><V><V><Q><K><A><L><Q><A><R><Q><A><S><P><A><W><K>
May play an important role in spermatogenesis and/or testis development.<BOP>
Q16626
Q96GM8
TOE1_HUMAN
Target of EGR1 protein 1
Homo
<M><A><A><D><S><D><D><G><A><V><S><A><P><A><A><S><D><G><G><V><S><K><S><T><T><S><G><E><E><L><V><V><Q><V><P><V><V><D><V><Q><S><N><N><F><K><E><M><W><P><S><L><L><L><A><I><K><T><A><N><F><V><A><V><D><T><E><L><S><G><L><G><D><R><K><S><L><L><N><Q><C><I><E><E><R><Y><K><A><V><C><H><A><A><R><T><R><S><I><L><S><L><G><L><A><C><F><K><R><Q><P><D><K><G><E><H><S><Y><L><A><Q><V><F><N><L><T><L><L><C><M><E><E><Y><V><I><E><P><K><S><V><Q><F><L><I><Q><H><G><F><N><F><N><Q><Q><Y><A><Q><G><I><P><Y><H><K><G><N><D><K><G><D><E><S><Q><S><Q><S><V><R><T><L><F><L><E><L><I><R><A><R><R><P><L><V><L><H><N><G><L><I><D><L><V><F><L><Y><Q><N><F><Y><A><H><L><P><E><S><L><G><T><F><T><A><D><L><C><E><M><F><P><A><G><I><Y><D><T><K><Y><A><A><E><F><H><A><R><F><V><A><S><Y><L><E><Y><A><F><R><K><C><E><R><E><N><G><K><Q><R><A><A><G><S><P><H><L><T><L><E><F><C><N><Y><P><S><S><M><R><D><H><I><D><Y><R><C><C><L><P><P><A><T><H><R><P><H><P><T><S><I><C><D><N><F><S><A><Y><G><W><C><P><L><G><P><Q><C><P><Q><S><H><D><I><D><L><I><I><D><T><D><E><A><A><A><E><D><K><R><R><R><R><R><R><R><E><K><R><K><R><A><L><L><N><L><P><G><T><Q><T><S><G><E><A><K><D><G><P><P><K><K><Q><V><C><G><D><S><I><K><P><E><E><T><E><Q><E><V><A><A><D><E><T><R><N><L><P><H><S><K><Q><G><N><K><N><D><L><E><M><G><I><K><A><A><R><P><E><I><A><D><R><A><T><S><E><V><P><G><S><Q><A><S><P><N><P><V><P><G><D><G><L><H><R><A><G><F><D><A><F><M><T><G><Y><V><M><A><Y><V><E><V><S><Q><G><P><Q><P><C><S><S><G><P><W><L><P><E><C><H><N><K><V><Y><L><S><G><K><A><V><P><L><T><V><A><K><S><Q><F><S><R><S><S><K><A><H><N><Q><K><M><K><L><T><W><G><S><S>
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing .<BOP>
Q96GM8
P16871
IL7RA_HUMAN
CDw127
Homo
<M><T><I><L><G><T><T><F><G><M><V><F><S><L><L><Q><V><V><S><G><E><S><G><Y><A><Q><N><G><D><L><E><D><A><E><L><D><D><Y><S><F><S><C><Y><S><Q><L><E><V><N><G><S><Q><H><S><L><T><C><A><F><E><D><P><D><V><N><I><T><N><L><E><F><E><I><C><G><A><L><V><E><V><K><C><L><N><F><R><K><L><Q><E><I><Y><F><I><E><T><K><K><F><L><L><I><G><K><S><N><I><C><V><K><V><G><E><K><S><L><T><C><K><K><I><D><L><T><T><I><V><K><P><E><A><P><F><D><L><S><V><V><Y><R><E><G><A><N><D><F><V><V><T><F><N><T><S><H><L><Q><K><K><Y><V><K><V><L><M><H><D><V><A><Y><R><Q><E><K><D><E><N><K><W><T><H><V><N><L><S><S><T><K><L><T><L><L><Q><R><K><L><Q><P><A><A><M><Y><E><I><K><V><R><S><I><P><D><H><Y><F><K><G><F><W><S><E><W><S><P><S><Y><Y><F><R><T><P><E><I><N><N><S><S><G><E><M><D><P><I><L><L><T><I><S><I><L><S><F><F><S><V><A><L><L><V><I><L><A><C><V><L><W><K><K><R><I><K><P><I><V><W><P><S><L><P><D><H><K><K><T><L><E><H><L><C><K><K><P><R><K><N><L><N><V><S><F><N><P><E><S><F><L><D><C><Q><I><H><R><V><D><D><I><Q><A><R><D><E><V><E><G><F><L><Q><D><T><F><P><Q><Q><L><E><E><S><E><K><Q><R><L><G><G><D><V><Q><S><P><N><C><P><S><E><D><V><V><I><T><P><E><S><F><G><R><D><S><S><L><T><C><L><A><G><N><V><S><A><C><D><A><P><I><L><S><S><S><R><S><L><D><C><R><E><S><G><K><N><G><P><H><V><Y><Q><D><L><L><L><S><L><G><T><T><N><S><T><L><P><P><P><F><S><L><Q><S><G><I><L><T><L><N><P><V><A><Q><G><Q><P><I><L><T><S><L><G><S><N><Q><E><E><A><Y><V><T><M><S><S><F><Y><Q><N><Q>
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).<BOP>
P16871
O00400
ACATN_HUMAN
Solute carrier family 33 member 1
Homo
<M><S><P><T><I><S><H><K><D><S><S><R><Q><R><R><P><G><N><F><S><H><S><L><D><M><K><S><G><P><L><P><P><G><G><W><D><D><S><H><L><D><S><A><G><R><E><G><D><R><E><A><L><L><G><D><T><G><T><G><D><F><L><K><A><P><Q><S><F><R><A><E><L><S><S><I><L><L><L><L><F><L><Y><V><L><Q><G><I><P><L><G><L><A><G><S><I><P><L><I><L><Q><S><K><N><V><S><Y><T><D><Q><A><F><F><S><F><V><F><W><P><F><S><L><K><L><L><W><A><P><L><V><D><A><V><Y><V><K><N><F><G><R><R><K><S><W><L><V><P><T><Q><Y><I><L><G><L><F><M><I><Y><L><S><T><Q><V><D><R><L><L><G><N><T><D><D><R><T><P><D><V><I><A><L><T><V><A><F><F><L><F><E><F><L><A><A><T><Q><D><I><A><V><D><G><W><A><L><T><M><L><S><R><E><N><V><G><Y><A><S><T><C><N><S><V><G><Q><T><A><G><Y><F><L><G><N><V><L><F><L><A><L><E><S><A><D><F><C><N><K><Y><L><R><F><Q><P><Q><P><R><G><I><V><T><L><S><D><F><L><F><F><W><G><T><V><F><L><I><T><T><T><L><V><A><L><L><K><K><E><N><E><V><S><V><V><K><E><E><T><Q><G><I><T><D><T><Y><K><L><L><F><A><I><I><K><M><P><A><V><L><T><F><C><L><L><I><L><T><A><K><I><G><F><S><A><A><D><A><V><T><G><L><K><L><V><E><E><G><V><P><K><E><H><L><A><L><L><A><V><P><M><V><P><L><Q><I><I><L><P><L><I><I><S><K><Y><T><A><G><P><Q><P><L><N><T><F><Y><K><A><M><P><Y><R><L><L><L><G><L><E><Y><A><L><L><V><W><W><T><P><K><V><E><H><Q><G><G><F><P><I><Y><Y><Y><I><V><V><L><L><S><Y><A><L><H><Q><V><T><V><Y><S><M><Y><V><S><I><M><A><F><N><A><K><V><S><D><P><L><I><G><G><T><Y><M><T><L><L><N><T><V><S><N><L><G><G><N><W><P><S><T><V><A><L><W><L><V><D><P><L><T><V><K><E><C><V><G><A><S><N><Q><N><C><R><T><P><D><A><V><E><L><C><K><K><L><G><G><S><C><V><T><A><L><D><G><Y><Y><V><E><S><I><I><C><V><F><I><G><F><G><W><W><F><F><L><G><P><K><F><K><K><L><Q><D><E><G><S><S><S><W><K><C><K><R><N><N>
Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides . Negatively regulates BMP signaling .<BOP>
O00400
Q9NZM5
NOP53_HUMAN
p60
Homo
<M><A><A><G><G><S><G><V><G><G><K><R><S><S><K><S><D><A><D><S><G><F><L><G><L><R><P><T><S><V><D><P><A><L><R><R><R><R><R><G><P><R><N><K><K><R><G><W><R><R><L><A><Q><E><P><L><G><L><E><V><D><Q><F><L><E><D><V><R><L><Q><E><R><T><S><G><G><L><L><S><E><A><P><N><E><K><L><F><F><V><D><T><G><S><K><E><K><G><L><T><K><K><R><T><K><V><Q><K><K><S><L><L><L><K><K><P><L><R><V><D><L><I><L><E><N><T><S><K><V><P><A><P><K><D><V><L><A><H><Q><V><P><N><A><K><K><L><R><R><K><E><Q><L><W><E><K><L><A><K><Q><G><E><L><P><R><E><V><R><R><A><Q><A><R><L><L><N><P><S><A><T><R><A><K><P><G><P><Q><D><T><V><E><R><P><F><Y><D><L><W><A><S><D><N><P><L><D><R><P><L><V><G><Q><D><E><F><F><L><E><Q><T><K><K><K><G><V><K><R><P><A><R><L><H><T><K><P><S><Q><A><P><A><V><E><V><A><P><A><G><A><S><Y><N><P><S><F><E><D><H><Q><T><L><L><S><A><A><H><E><V><E><L><Q><R><Q><K><E><A><E><K><L><E><R><Q><L><A><L><P><A><T><E><Q><A><A><T><Q><E><S><T><F><Q><E><L><C><E><G><L><L><E><E><S><D><G><E><G><E><P><G><Q><G><E><G><P><E><A><G><D><A><E><V><C><P><T><P><A><R><L><A><T><T><E><K><K><T><E><Q><Q><R><R><R><E><K><A><V><H><R><L><R><V><Q><Q><A><A><L><R><A><A><R><L><R><H><Q><E><L><F><R><L><R><G><I><K><A><Q><V><A><L><R><L><A><E><L><A><R><R><Q><R><R><R><Q><A><R><R><E><A><E><A><D><K><P><R><R><L><G><R><L><K><Y><Q><A><P><D><I><D><V><Q><L><S><S><E><L><T><D><S><L><R><T><L><K><P><E><G><N><I><L><R><D><R><F><K><S><F><Q><R><R><N><M><I><E><P><R><E><R><A><K><F><K><R><K><Y><K><V><K><L><V><E><K><R><A><F><R><E><I><Q><L>
Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis . In ribosome biogenesis, may also play a role in rRNA transcription . Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions . DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation . It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation . Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway . May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 . May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation .
Q9NZM5
Q9NQF3
SERHL_HUMAN
Serine hydrolase-like protein
Homo
<M><A><E><N><A><A><P><G><L><I><S><E><L><K><L><A><V><P><W><G><H><I><A><A><K><A><W><G><S><L><Q><G><P><P><V><L><C><L><H><G><W><L><D><N><A><S><S><F><D><R><L><I><P><L><L><P><Q><D><F><Y><Y><V><A><M><D><F><G><G><H><G><L><S><S><H><Y><S><P><G><V><P><Y><Y><L><Q><T><F><V><S><E><I><R><R><V><V><A><A><L><K><W><N><R><F><S><I><L><G><H><S><F><G><G><V><V><G><G><M><F><F><C><T><F><P><E><M><V><D><K><L><I><L><L><D><T><P><L><F><L><L><E><S><D><E><M><E><N><L><L><T><Y><K><R><R><A><I><E><H><V><L><Q><V><E><A><S><Q><E><P><S><H><V><F><S><L><K><Q><L><L><Q><R><Q><R><T><A><L><T><S><S><A><G><S><C><V><R><I><P><S><G><S><C><R><P><M><S><C>
Putative serine hydrolase.<BOP>
Q9NQF3
P15509
CSF2R_HUMAN
CDw116
Homo
<M><L><L><L><V><T><S><L><L><L><C><E><L><P><H><P><A><F><L><L><I><P><E><K><S><D><L><R><T><V><A><P><A><S><S><L><N><V><R><F><D><S><R><T><M><N><L><S><W><D><C><Q><E><N><T><T><F><S><K><C><F><L><T><D><K><K><N><R><V><V><E><P><R><L><S><N><N><E><C><S><C><T><F><R><E><I><C><L><H><E><G><V><T><F><E><V><H><V><N><T><S><Q><R><G><F><Q><Q><K><L><L><Y><P><N><S><G><R><E><G><T><A><A><Q><N><F><S><C><F><I><Y><N><A><D><L><M><N><C><T><W><A><R><G><P><T><A><P><R><D><V><Q><Y><F><L><Y><I><R><N><S><K><R><R><R><E><I><R><C><P><Y><Y><I><Q><D><S><G><T><H><V><G><C><H><L><D><N><L><S><G><L><T><S><R><N><Y><F><L><V><N><G><T><S><R><E><I><G><I><Q><F><F><D><S><L><L><D><T><K><K><I><E><R><F><N><P><P><S><N><V><T><V><R><C><N><T><T><H><C><L><V><R><W><K><Q><P><R><T><Y><Q><K><L><S><Y><L><D><F><Q><Y><Q><L><D><V><H><R><K><N><T><Q><P><G><T><E><N><L><L><I><N><V><S><G><D><L><E><N><R><Y><N><F><P><S><S><E><P><R><A><K><H><S><V><K><I><R><A><A><D><V><R><I><L><N><W><S><S><W><S><E><A><I><E><F><G><S><D><D><G><N><L><G><S><V><Y><I><Y><V><L><L><I><V><G><T><L><V><C><G><I><V><L><G><F><L><F><K><R><F><L><R><I><Q><R><L><F><P><P><V><P><Q><I><K><D><K><L><N><D><N><H><E><V><E><D><E><I><I><W><E><E><F><T><P><E><E><G><K><G><Y><R><E><E><V><L><T><V><K><E><I><T>
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.<BOP>
P15509
Q8WUH1
CHUR_HUMAN
Protein Churchill
Homo
<M><C><G><D><C><V><E><K><E><Y><P><N><R><G><N><T><C><L><E><N><G><S><F><L><L><N><F><T><G><C><A><V><C><S><K><R><D><F><M><L><I><T><N><K><S><L><K><E><E><D><G><E><E><I><V><T><Y><D><H><L><C><K><N><C><H><H><V><I><A><R><H><E><Y><T><F><S><I><M><D><E><F><Q><E><Y><T><M><L><C><L><L><C><G><K><A><E><D><T><I><S><I><L><P><D><D><P><R><Q><M><T><L><L><F>
Does not bind DNA by itself.<BOP>
Q8WUH1
Q3LHN2
KR192_HUMAN
Keratin-associated protein 19-2
Homo
<M><C><Y><G><Y><G><C><G><C><G><S><F><C><R><L><G><Y><G><C><G><Y><E><G><C><R><Y><G><C><G><H><R><G><C><G><D><G><C><C><C><P><S><C><Y><R><R><Y><R><F><T><G><F><Y>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q3LHN2
Q9UBE8
NLK_HUMAN
Protein LAK1
Homo
<M><S><L><C><G><A><R><A><N><A><K><M><M><A><A><Y><N><G><G><T><S><A><A><A><A><G><H><H><H><H><H><H><H><H><L><P><H><L><P><P><P><H><L><H><H><H><H><H><P><Q><H><H><L><H><P><G><S><A><A><A><V><H><P><V><Q><Q><H><T><S><S><A><A><A><A><A><A><A><A><A><A><A><A><A><M><L><N><P><G><Q><Q><Q><P><Y><F><P><S><P><A><P><G><Q><A><P><G><P><A><A><A><A><P><A><Q><V><Q><A><A><A><A><A><T><V><K><A><H><H><H><Q><H><S><H><H><P><Q><Q><Q><L><D><I><E><P><D><R><P><I><G><Y><G><A><F><G><V><V><W><S><V><T><D><P><R><D><G><K><R><V><A><L><K><K><M><P><N><V><F><Q><N><L><V><S><C><K><R><V><F><R><E><L><K><M><L><C><F><F><K><H><D><N><V><L><S><A><L><D><I><L><Q><P><P><H><I><D><Y><F><E><E><I><Y><V><V><T><E><L><M><Q><S><D><L><H><K><I><I><V><S><P><Q><P><L><S><S><D><H><V><K><V><F><L><Y><Q><I><L><R><G><L><K><Y><L><H><S><A><G><I><L><H><R><D><I><K><P><G><N><L><L><V><N><S><N><C><V><L><K><I><C><D><F><G><L><A><R><V><E><E><L><D><E><S><R><H><M><T><Q><E><V><V><T><Q><Y><Y><R><A><P><E><I><L><M><G><S><R><H><Y><S><N><A><I><D><I><W><S><V><G><C><I><F><A><E><L><L><G><R><R><I><L><F><Q><A><Q><S><P><I><Q><Q><L><D><L><I><T><D><L><L><G><T><P><S><L><E><A><M><R><T><A><C><E><G><A><K><A><H><I><L><R><G><P><H><K><Q><P><S><L><P><V><L><Y><T><L><S><S><Q><A><T><H><E><A><V><H><L><L><C><R><M><L><V><F><D><P><S><K><R><I><S><A><K><D><A><L><A><H><P><Y><L><D><E><G><R><L><R><Y><H><T><C><M><C><K><C><C><F><S><T><S><T><G><R><V><Y><T><S><D><F><E><P><V><T><N><P><K><F><D><D><T><F><E><K><N><L><S><S><V><R><Q><V><K><E><I><I><H><Q><F><I><L><E><Q><Q><K><G><N><R><V><P><L><C><I><N><P><Q><S><A><A><F><K><S><F><I><S><S><T><V><A><Q><P><S><E><M><P><P><S><P><L><V><W><E>
Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be
Q9UBE8
Q6ZVX9
PAQR9_HUMAN
Progestin and adipoQ receptor family member IX
Homo
<M><P><R><R><L><Q><P><R><G><A><G><T><K><G><P><P><A><P><A><P><A><A><S><G><A><A><R><N><S><H><S><A><A><S><R><D><P><P><A><S><A><K><P><L><L><R><W><D><E><V><P><D><D><F><V><E><C><F><I><L><S><G><Y><R><R><L><P><C><T><A><Q><E><C><L><A><S><V><L><K><P><T><N><E><T><L><N><F><W><T><H><F><I><P><L><L><L><F><L><S><K><F><C><R><L><F><F><L><S><G><G><D><V><P><F><H><H><P><W><L><L><P><L><W><C><Y><A><S><G><V><L><L><T><F><A><M><S><C><T><A><H><V><F><S><C><L><S><L><R><L><R><A><A><F><F><Y><L><D><Y><A><S><I><S><Y><Y><G><F><G><S><T><V><A><Y><Y><Y><Y><L><L><P><G><L><S><L><L><D><A><R><V><M><T><P><Y><L><Q><Q><R><L><G><W><H><V><D><C><T><R><L><I><A><A><Y><R><A><L><V><L><P><V><A><F><V><L><A><V><A><C><T><V><A><C><C><K><S><R><T><D><W><C><T><Y><P><F><A><L><R><T><F><V><F><V><M><P><L><S><M><A><C><P><I><M><L><E><S><W><L><F><D><L><R><G><E><N><P><T><L><F><V><H><F><Y><R><R><Y><F><W><L><V><V><A><A><F><F><N><V><S><K><I><P><E><R><I><Q><P><G><L><F><D><I><I><G><H><S><H><Q><L><F><H><I><F><T><F><L><S><I><Y><D><Q><V><Y><Y><V><E><E><G><L><R><Q><F><L><Q><A><P><P><A><A><P><T><F><S><G><T><V><G><Y><M><L><L><L><V><V><C><L><G><L><V><I><R><K><F><L><N><S><S><E><F><C><S><K><K>
Plasma membrane progesterone (P4) receptor coupled to G proteins . Seems to act through a G(s) mediated pathway . May be involved in regulating rapid P4 signaling in the nervous system . Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone .<BOP>
Q6ZVX9
P26371
KRA59_HUMAN
Ultrahigh sulfur keratin-associated protein 5.9
Homo
<M><G><C><C><G><C><S><G><G><C><G><S><S><C><G><G><C><D><S><S><C><G><S><C><G><S><G><C><R><G><C><G><P><S><C><C><A><P><V><Y><C><C><K><P><V><C><C><C><V><P><A><C><S><C><S><S><C><G><K><R><G><C><G><S><C><G><G><S><K><G><G><C><G><S><C><G><C><S><Q><C><S><C><C><K><P><C><C><C><S><S><G><C><G><S><S><C><C><Q><C><S><C><C><K><P><Y><C><S><Q><C><S><C><C><K><P><C><C><S><S><S><G><R><G><S><S><C><C><Q><S><S><C><C><K><P><C><C><S><S><S><G><C><G><S><S><C><C><Q><S><S><C><C><K><P><C><C><S><Q><S><R><C><C><V><P><V><C><Y><Q><C><K><I>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
P26371
P50150
GBG4_HUMAN
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Homo
<M><K><E><G><M><S><N><N><S><T><T><S><I><S><Q><A><R><K><A><V><E><Q><L><K><M><E><A><C><M><D><R><V><K><V><S><Q><A><A><A><D><L><L><A><Y><C><E><A><H><V><R><E><D><P><L><I><I><P><V><P><A><S><E><N><P><F><R><E><K><K><F><F><C><T><I><L>
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<BOP>
P50150
Q8WVD3
RN138_HUMAN
RING-type E3 ubiquitin transferase RNF138
Homo
<M><A><E><D><L><S><A><A><T><S><Y><T><E><D><D><F><Y><C><P><V><C><Q><E><V><L><K><T><P><V><R><T><T><A><C><Q><H><V><F><C><R><K><C><F><L><T><A><M><R><E><S><G><A><H><C><P><L><C><R><G><N><V><T><R><R><E><R><A><C><P><E><R><A><L><D><L><E><N><I><M><R><K><F><S><G><S><C><R><C><C><A><K><Q><I><K><F><Y><R><M><R><H><H><Y><K><S><C><K><K><Y><Q><D><E><Y><G><V><S><S><I><I><P><N><F><Q><I><S><Q><D><S><V><G><N><S><N><R><S><E><T><S><T><S><D><N><T><E><T><Y><Q><E><N><T><S><S><S><G><H><P><T><F><K><C><P><L><C><Q><E><S><N><F><T><R><Q><R><L><L><D><H><C><N><S><N><H><L><F><Q><I><V><P><V><T><C><P><I><C><V><S><L><P><W><G><D><P><S><Q><I><T><R><N><F><V><S><H><L><N><Q><R><H><Q><F><D><Y><G><E><F><V><N><L><Q><L><D><E><E><T><Q><Y><Q><T><A><V><E><E><S><F><Q><V><N><I>
E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination . Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination . Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination . According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP . Together with NLK, involved in the ubiquitination and degradation of TCF/LEF . Also exhibits auto-ubiquitination activity in combination with UBE2K . May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway .<BOP>
Q8WVD3
M5A8F1
SUPYN_HUMAN
endogenous retrovirus group Fb member 1
Homo
<M><A><C><I><Y><P><T><T><F><Y><T><S><L><P><T><K><S><L><N><M><G><I><S><L><T><T><I><L><I><L><S><V><A><V><L><L><S><T><A><A><P><P><S><C><R><E><C><Y><Q><S><L><H><Y><R><G><E><M><Q><Q><Y><F><T><Y><H><T><H><I><E><R><S><C><Y><G><N><L><I><E><E><C><V><E><S><G><K><S><Y><Y><K><V><K><N><L><G><V><C><G><S><R><N><G><A><I><C><P><R><G><K><Q><W><L><C><F><T><K><I><G><Q><W><G><V><N><T><Q><V><L><E><D><I><K><R><E><Q><I><I><A><K><A><K><A><S><K><P><T><T><P><P><E><N><R><P><R><H><F><H><S><F><I><Q><K><L>
May play a role in trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development. May negatively regulate cell-cell fusion by interacting with SLC1A5, the probable receptor on the cell surface of the fusogenic syncytin-1/ERVW-1.<BOP>
M5A8F1
Q8NGX3
O10T2_HUMAN
Olfactory receptor OR1-3
Homo
<M><R><G><F><N><K><T><T><V><V><T><Q><F><I><L><V><G><F><S><S><L><G><E><L><Q><L><L><L><F><V><I><F><L><L><L><Y><L><T><I><L><V><A><N><V><T><I><M><A><V><I><R><F><S><W><T><L><H><T><P><M><Y><G><F><L><F><I><L><S><F><S><E><S><C><Y><T><F><V><I><I><P><Q><L><L><V><H><L><L><S><D><T><K><T><I><S><F><M><A><C><A><T><Q><L><F><F><F><L><G><F><A><C><T><N><C><L><L><I><A><V><M><G><Y><D><R><Y><V><A><I><C><H><P><L><R><Y><T><L><I><I><N><K><R><L><G><L><E><L><I><S><L><S><G><A><T><G><F><F><I><A><L><V><A><T><N><L><I><C><D><M><R><F><C><G><P><N><R><V><N><H><Y><F><C><D><M><A><P><V><I><K><L><A><C><T><D><T><H><V><K><E><L><A><L><F><S><L><S><I><L><V><I><M><V><P><F><L><L><I><L><I><S><Y><G><F><I><V><N><T><I><L><K><I><P><S><A><E><G><K><K><A><F><V><T><C><A><S><H><L><T><V><V><F><V><H><Y><G><C><A><S><I><I><Y><L><R><P><K><S><K><S><A><S><D><K><D><Q><L><V><A><V><T><Y><T><V><V><T><P><L><L><N><P><L><V><Y><S><L><R><N><K><E><V><K><T><A><L><K><R><V><L><G><M><P><V><A><T><K><M><S>
Odorant receptor.<BOP>
Q8NGX3
Q8IYA7
MKX_HUMAN
Homeobox protein Mohawk
Homo
<M><N><T><I><V><F><N><K><L><S><G><A><V><L><F><E><D><G><G><A><S><E><R><E><R><G><G><R><P><Y><S><G><V><L><D><S><P><H><A><R><P><E><V><G><I><P><D><G><P><P><L><K><D><N><L><G><L><R><H><R><R><T><G><A><R><Q><N><G><G><K><V><R><H><K><R><Q><A><L><Q><D><M><A><R><P><L><K><Q><W><L><Y><K><H><R><D><N><P><Y><P><T><K><T><E><K><I><L><L><A><L><G><S><Q><M><T><L><V><Q><V><S><N><W><F><A><N><A><R><R><R><L><K><N><T><V><R><Q><P><D><L><S><W><A><L><R><I><K><L><Y><N><K><Y><V><Q><G><N><A><E><R><L><S><V><S><S><D><D><S><C><S><E><D><G><E><N><P><P><R><T><H><M><N><E><G><G><Y><N><T><P><V><H><H><P><V><I><K><S><E><N><S><V><I><K><A><G><V><R><P><E><S><R><A><S><E><D><Y><V><A><P><P><K><Y><K><S><S><L><L><N><R><Y><L><N><D><S><L><R><H><V><M><A><T><N><T><T><M><M><G><K><T><R><Q><R><N><H><S><G><S><F><S><S><N><E><F><E><E><E><L><V><S><P><S><S><S><E><T><E><G><N><F><V><Y><R><T><D><T><L><E><N><G><S><N><K><G><E><S><A><A><N><R><K><G><P><S><K><D><D><T><Y><W><K><E><I><N><A><A><M><A><L><T><N><L><A><Q><G><K><D><K><L><Q><G><T><T><S><C><I><I><Q><K><S><S><H><I><A><E><V><K><T><V><K><V><P><L><V><Q><Q><F>
May act as a morphogenetic regulator of cell adhesion.<BOP>
Q8IYA7
Q3LI61
KR202_HUMAN
Keratin-associated protein 20-2
Homo
<M><C><Y><Y><S><N><Y><Y><G><G><L><R><Y><G><Y><G><V><L><G><G><G><Y><G><C><G><C><G><Y><G><H><G><Y><G><G><L><G><C><G><Y><G><R><G><Y><G><G><Y><G><Y><G><C><C><R><P><S><C><Y><G><R><Y><W><S><C><G><F><Y>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q3LI61
Q12870
TCF15_HUMAN
Protein bHLH-EC2
Homo
<M><A><F><A><L><L><R><P><V><G><A><H><V><L><Y><P><D><V><R><L><L><S><E><D><E><E><N><R><S><E><S><D><A><S><D><Q><S><F><G><C><C><E><G><P><E><A><A><R><R><G><P><G><P><G><G><G><R><R><A><G><G><G><G><G><A><G><P><V><V><V><V><R><Q><R><Q><A><A><N><A><R><E><R><D><R><T><Q><S><V><N><T><A><F><T><A><L><R><T><L><I><P><T><E><P><V><D><R><K><L><S><K><I><E><T><V><R><L><A><S><S><Y><I><A><H><L><A><N><V><L><L><L><G><D><S><A><D><D><G><Q><P><C><F><R><A><A><G><S><A><K><G><A><V><P><A><A><A><D><G><G><R><Q><P><R><S><I><C><T><F><C><L><S><N><Q><R><K><G><G><G><R><R><D><L><G><G><S><C><L><K><V><R><G><V><A><P><L><R><G><P><R><R>
Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency. Essential for the mesenchymal to epithelial transition associated with somite formation. Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles. Required for proper localization of somite epithelium markers during the mesenchymal to epithelial transition. Also plays a key role in regulation of stem cell pluripotency. Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation. Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long-term self-renewal. Together with MEOX2, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells. Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, such as TCF3/E12, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes.<BOP>
Q12870
Q8WZA6
OR1E3_HUMAN
Olfactory receptor OR17-7
Homo
<M><M><K><K><N><Q><T><M><I><S><E><F><L><L><L><G><L><P><I><Q><P><E><Q><Q><N><L><F><Y><A><L><F><L><A><V><Y><L><T><T><L><L><G><N><L><L><V><I><V><L><I><R><L><D><S><H><L><H><M><P><M><Y><L><C><L><S><N><L><S><F><S><D><L><C><F><S><S><V><T><M><P><K><L><L><Q><N><M><Q><S><Q><N><P><S><I><P><F><A><D><C><L><A><Q><M><Y><F><H><L><F><Y><G><V><L><E><S><F><L><L><V><V><M><A><Y><H><C><Y><V><A><I><C><F><P><L><H><Y><T><T><I><M><S><P><K><C><C><L><G><L><L><T><L><S><W><L><L><T><T><A><H><A><T><L><H><T><L><L><M><A><R><L><S><F><C><A><E><N><V><I><P><H><F><F><C><D><T><S><T><L><L><K><L><A><C><S><N><T><Q><V><N><G><W><V><M><F><F><M><G><G><L><I><L><V><I><P><F><L><L><L><I><M><S><C><A><R><I><V><S><T><I><L><R><V><P><S><T><G><G><I><Q><K><A><F><S><T><C><G><P><H><L><S><V><V><S><L><F><Y><G><T><I><I><G><L><Y><L><C><P><L><T><N><H><N><T><V><K><D><T><V><M><A><V><M><Y><T><G><V><T><H><M><L><N><P><F><I><Y><S><L><R><N><R><D><M><R><G><N><P><G><Q><S><L><Q><H><K><E><N><F><F><V><F><K><I><V><I><V><G><I><L><P><L><L><N><L><V><G><V><V><K><L><I><M><K><Y><H><S><K><S><V><A>
Odorant receptor.<BOP>
Q8WZA6
Q6NXR4
TTI2_HUMAN
TELO2-interacting protein 2
Homo
<M><E><L><D><S><A><L><E><A><P><S><Q><E><D><S><N><L><S><E><E><L><S><H><S><A><F><G><Q><A><F><S><K><I><L><H><C><L><A><R><P><E><A><R><R><G><N><V><K><D><A><V><L><K><D><L><G><D><L><I><E><A><T><E><F><D><R><L><F><E><G><T><G><A><R><L><R><G><M><P><E><T><L><G><Q><V><A><K><A><L><E><K><Y><A><A><P><S><K><E><E><E><G><G><G><D><G><H><S><E><A><A><E><K><A><A><Q><V><G><L><L><F><L><K><L><L><G><K><V><E><T><A><K><N><S><L><V><G><P><A><W><Q><T><G><L><H><H><L><A><G><P><V><Y><I><F><A><I><T><H><S><L><E><Q><P><W><T><T><P><R><S><R><E><V><A><R><E><V><L><T><S><L><L><Q><V><T><E><C><G><S><V><A><G><F><L><H><G><E><N><E><D><E><K><G><R><L><S><V><I><L><G><L><L><K><P><D><L><Y><K><E><S><W><K><N><N><P><A><I><K><H><V><F><S><W><T><L><Q><Q><V><T><R><P><W><L><S><Q><H><L><E><R><V><L><P><A><S><L><V><I><S><D><D><Y><Q><T><E><N><K><I><L><G><V><H><C><L><H><H><I><V><L><N><V><P><A><A><D><L><L><Q><Y><N><R><A><Q><V><L><Y><H><A><I><S><N><H><L><Y><T><P><E><H><H><L><I><Q><A><V><L><L><C><L><L><D><L><F><P><I><L><E><K><T><L><H><W><K><G><D><G><A><R><P><T><T><H><C><D><E><V><L><R><L><I><L><T><H><M><E><P><E><H><R><L><L><L><R><R><T><Y><A><R><N><L><P><A><F><V><N><R><L><G><I><L><T><V><R><H><L><K><R><L><E><R><V><I><I><G><Y><L><E><V><Y><D><G><P><E><E><E><A><R><L><K><I><L><E><T><L><K><L><L><M><Q><H><T><W><P><R><V><S><C><R><L><V><V><L><L><K><A><L><L><K><L><I><C><D><V><A><R><D><P><N><L><T><P><E><S><V><K><S><A><L><L><Q><E><A><T><D><C><L><I><L><L><D><R><C><S><Q><G><R><V><K><G><L><L><A><K><I><P><Q><S><C><E><D><R><K><V><V><N><Y><I><R><K><V><Q><Q><V><S><E><G><A><P><Y><N><G><T>
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs.<BOP>
Q6NXR4
O00116
ADAS_HUMAN
Alkylglycerone-phosphate synthase
Homo
<M><A><E><A><A><A><A><A><G><G><T><G><L><G><A><G><A><S><Y><G><S><A><A><D><R><D><R><D><P><D><P><D><R><A><G><R><R><L><R><V><L><S><G><H><L><L><G><R><P><R><E><A><L><S><T><N><E><C><K><A><R><R><A><A><S><A><A><T><A><A><P><T><A><T><P><A><A><Q><E><S><G><T><I><P><K><K><R><Q><E><V><M><K><W><N><G><W><G><Y><N><D><S><K><F><I><F><N><K><K><G><Q><I><E><L><T><G><K><R><Y><P><L><S><G><M><G><L><P><T><F><K><E><W><I><Q><N><T><L><G><V><N><V><E><H><K><T><T><S><K><A><S><L><N><P><S><D><T><P><P><S><V><V><N><E><D><F><L><H><D><L><K><E><T><N><I><S><Y><S><Q><E><A><D><D><R><V><F><R><A><H><G><H><C><L><H><E><I><F><L><L><R><E><G><M><F><E><R><I><P><D><I><V><L><W><P><T><C><H><D><D><V><V><K><I><V><N><L><A><C><K><Y><N><L><C><I><I><P><I><G><G><G><T><S><V><S><Y><G><L><M><C><P><A><D><E><T><R><T><I><I><S><L><D><T><S><Q><M><N><R><I><L><W><V><D><E><N><N><L><T><A><H><V><E><A><G><I><T><G><Q><E><L><E><R><Q><L><K><E><S><G><Y><C><T><G><H><E><P><D><S><L><E><F><S><T><V><G><G><W><V><S><T><R><A><S><G><M><K><K><N><I><Y><G><N><I><E><D><L><V><V><H><I><K><M><V><T><P><R><G><I><I><E><K><S><C><Q><G><P><R><M><S><T><G><P><D><I><H><H><F><I><M><G><S><E><G><T><L><G><V><I><T><E><A><T><I><K><I><R><P><V><P><E><Y><Q><K><Y><G><S><V><A><F><P><N><F><E><Q><G><V><A><C><L><R><E><I><A><K><Q><R><C><A><P><A><S><I><R><L><M><D><N><K><Q><F><Q><F><G><H><A><L><K><P><Q><V><S><S><I><F><T><S><F><L><D><G><L><K><K><F><Y><I><T><K><F><K><G><F><D><P><N><Q><L><S><V><A><T><L><L><F><E><G><D><R><E><K><V><L><Q><H><E><K><Q><V><Y><D><I><A><A><K><F><G><G><L><A><A><G><E><D><N><G><Q><R><G><Y><L><L><T><Y><V><I><A><Y><I><R><D><L><A><L><E><Y><Y><V><L><G><E><S><F><E><T><S><A><P><W><D><R><V><V><D><L><C><R><N><V><K><E><R><I><T><R><E><C><K><E><K><G><V><Q><F><A><P><F><S><T><C><R><V><T><Q><T><Y><D><A><G><A><C><I><Y><F><Y><F><A><F><N><Y><R><G><I><S><D><P><L><T><V><F><E><Q><T><E><A><A><A><R><E><E><I><L><A><N><G><G><S><L><S><H><H><H><G><V><G><K><L><R><K><Q><W><L><K><E><S><I><S><D><V><G><F><G><M><L><K><S><V><K><E><Y><V><D><P><N><N><I><F><G><N><R><N><L><L>
Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis.<BOP>
O00116
Q9NZB8
MOCS1_HUMAN
Molybdenum cofactor biosynthesis protein C
Homo
<M><A><A><R><P><L><S><R><M><L><R><R><L><L><R><S><S><A><R><S><C><S><S><G><A><P><V><T><Q><P><C><P><G><E><S><A><R><A><A><S><E><E><V><S><R><R><R><Q><F><L><R><E><H><A><A><P><F><S><A><F><L><T><D><S><F><G><R><Q><H><S><Y><L><R><I><S><L><T><E><K><C><N><L><R><C><Q><Y><C><M><P><E><E><G><V><P><L><T><P><K><A><N><L><L><T><T><E><E><I><L><T><L><A><R><L><F><V><K><E><G><I><D><K><I><R><L><T><G><G><E><P><L><I><R><P><D><V><V><D><I><V><A><Q><L><Q><R><L><E><G><L><R><T><I><G><V><T><T><N><G><I><N><L><A><R><L><L><P><Q><L><Q><K><A><G><L><S><A><I><N><I><S><L><D><T><L><V><P><A><K><F><E><F><I><V><R><R><K><G><F><H><K><V><M><E><G><I><H><K><A><I><E><L><G><Y><N><P><V><K><V><N><C><V><V><M><R><G><L><N><E><D><E><L><L><D><F><A><A><L><T><E><G><L><P><L><D><V><R><F><I><E><Y><M><P><F><D><G><N><K><W><N><F><K><K><M><V><S><Y><K><E><M><L><D><T><V><R><Q><Q><W><P><E><L><E><K><V><P><E><E><E><S><S><T><A><K><A><F><K><I><P><G><F><Q><G><Q><I><S><F><I><T><S><M><S><E><H><F><C><G><T><C><N><R><L><R><I><T><A><D><G><N><L><K><V><C><L><F><G><N><S><E><V><S><L><R><D><H><L><R><A><G><A><S><E><Q><E><L><L><R><I><I><G><A><A><V><G><R><K><K><R><Q><H><A><G><M><F><S><I><S><Q><M><K><N><R><P><M><I><L><I><E><L><F><L><M><F><P><N><S><P><P><A><N><P><S><I><F><S><W><D><P><L><H><V><Q><G><L><R><P><R><M><S><F><S><S><Q><V><A><T><L><W><K><G><C><R><V><P><Q><T><P><P><L><A><Q><Q><R><L><G><S><G><S><F><Q><R><H><Y><T><S><R><A><D><S><D><A><N><S><K><C><L><S><P><G><S><W><A><S><A><A><P><S><G><P><Q><L><T><S><E><Q><L><T><H><V><D><S><E><G><R><A><A><M><V><D><V><G><R><K><P><D><T><E><R><V><A><V><A><S><A><V><V><L><L><G><P><V><A><F><K><L><V><Q><Q><N><Q><L><K><K><G><D><A><L><V><V><A><Q><L><A><G><V><Q><A><A><K><V><T><S><Q><L><I><P><L><C><H><H><V><A><L><S><H><I><Q><V><Q><L><E><L><D><S><T><R><H><A><V><K><I><Q><A><S><C><R><A><R><G><P><T><G><V><E><M><E><A><L><T><S><A><A><V><A><A><L><T><L><Y><D><M><C><K><A><V><S><R><D><I><V><L><E><E><I><K><L><I><S><K><T><G><G><Q><R><G><D><F><H><R><A>
Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.<BOP>
Q9NZB8
Q14653
IRF3_HUMAN
Interferon regulatory factor 3
Homo
<M><G><T><P><K><P><R><I><L><P><W><L><V><S><Q><L><D><L><G><Q><L><E><G><V><A><W><V><N><K><S><R><T><R><F><R><I><P><W><K><H><G><L><R><Q><D><A><Q><Q><E><D><F><G><I><F><Q><A><W><A><E><A><T><G><A><Y><V><P><G><R><D><K><P><D><L><P><T><W><K><R><N><F><R><S><A><L><N><R><K><E><G><L><R><L><A><E><D><R><S><K><D><P><H><D><P><H><K><I><Y><E><F><V><N><S><G><V><G><D><F><S><Q><P><D><T><S><P><D><T><N><G><G><G><S><T><S><D><T><Q><E><D><I><L><D><E><L><L><G><N><M><V><L><A><P><L><P><D><P><G><P><P><S><L><A><V><A><P><E><P><C><P><Q><P><L><R><S><P><S><L><D><N><P><T><P><F><P><N><L><G><P><S><E><N><P><L><K><R><L><L><V><P><G><E><E><W><E><F><E><V><T><A><F><Y><R><G><R><Q><V><F><Q><Q><T><I><S><C><P><E><G><L><R><L><V><G><S><E><V><G><D><R><T><L><P><G><W><P><V><T><L><P><D><P><G><M><S><L><T><D><R><G><V><M><S><Y><V><R><H><V><L><S><C><L><G><G><G><L><A><L><W><R><A><G><Q><W><L><W><A><Q><R><L><G><H><C><H><T><Y><W><A><V><S><E><E><L><L><P><N><S><G><H><G><P><D><G><E><V><P><K><D><K><E><G><G><V><F><D><L><G><P><F><I><V><D><L><I><T><F><T><E><G><S><G><R><S><P><R><Y><A><L><W><F><C><V><G><E><S><W><P><Q><D><Q><P><W><T><K><R><L><V><M><V><K><V><V><P><T><C><L><R><A><L><V><E><M><A><R><V><G><G><A><S><S><L><E><N><T><V><D><L><H><I><S><N><S><H><P><L><S><L><T><S><D><Q><Y><K><A><Y><L><Q><D><L><V><E><G><M><D><F><Q><G><P><G><E><S>
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses . Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters . Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction . Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases . This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes . Can activate distinct gene expression programs in macrophages and can induce significant apoptosis
Q14653
Q8NGK5
O52M1_HUMAN
Olfactory receptor OR11-11
Homo
<M><L><T><F><H><N><V><C><S><V><P><S><S><F><W><L><T><G><I><P><G><L><E><S><L><H><V><W><L><S><I><P><F><G><S><M><Y><L><V><A><V><V><G><N><V><T><I><L><A><V><V><K><I><E><R><S><L><H><Q><P><M><Y><F><F><L><C><M><L><A><A><I><D><L><V><L><S><T><S><T><I><P><K><L><L><G><I><F><W><F><G><A><C><D><I><G><L><D><A><C><L><G><Q><M><F><L><I><H><C><F><A><T><V><E><S><G><I><F><L><A><M><A><F><D><R><Y><V><A><I><C><N><P><L><R><H><S><M><V><L><T><Y><T><V><V><G><R><L><G><L><V><S><L><L><R><G><V><L><Y><I><G><P><L><P><L><M><I><R><L><R><L><P><L><Y><K><T><H><V><I><S><H><S><Y><C><E><H><M><A><V><V><A><L><T><C><G><D><S><R><V><N><N><V><Y><G><L><S><I><G><F><L><V><L><I><L><D><S><V><A><I><A><A><S><Y><V><M><I><F><R><A><V><M><G><L><A><T><P><E><A><R><L><K><T><L><G><T><C><A><S><H><L><C><A><I><L><I><F><Y><V><P><I><A><V><S><S><L><I><H><R><F><G><Q><C><V><P><P><P><V><H><T><L><L><A><N><F><Y><L><L><I><P><P><I><L><N><P><I><V><Y><A><V><R><T><K><Q><I><R><E><S><L><L><Q><I><P><R><I><E><M><K><I><R>
Odorant receptor.<BOP>
Q8NGK5
P49685
GPR15_HUMAN
Brother of Bonzo
Homo
<M><D><P><E><E><T><S><V><Y><L><D><Y><Y><Y><A><T><S><P><N><S><D><I><R><E><T><H><S><H><V><P><Y><T><S><V><F><L><P><V><F><Y><T><A><V><F><L><T><G><V><L><G><N><L><V><L><M><G><A><L><H><F><K><P><G><S><R><R><L><I><D><I><F><I><I><N><L><A><A><S><D><F><I><F><L><V><T><L><P><L><W><V><D><K><E><A><S><L><G><L><W><R><T><G><S><F><L><C><K><G><S><S><Y><M><I><S><V><N><M><H><C><S><V><L><L><L><T><C><M><S><V><D><R><Y><L><A><I><V><W><P><V><V><S><R><K><F><R><R><T><D><C><A><Y><V><V><C><A><S><I><W><F><I><S><C><L><L><G><L><P><T><L><L><S><R><E><L><T><L><I><D><D><K><P><Y><C><A><E><K><K><A><T><P><I><K><L><I><W><S><L><V><A><L><I><F><T><F><F><V><P><L><L><S><I><V><T><C><Y><C><C><I><A><R><K><L><C><A><H><Y><Q><Q><S><G><K><H><N><K><K><L><K><K><S><I><K><I><I><F><I><V><V><A><A><F><L><V><S><W><L><P><F><N><T><F><K><F><L><A><I><V><S><G><L><R><Q><E><H><Y><L><P><S><A><I><L><Q><L><G><M><E><V><S><G><P><L><A><F><A><N><S><C><V><N><P><F><I><Y><Y><I><F><D><S><Y><I><R><R><A><I><V><H><C><L><C><P><C><L><K><N><Y><D><F><G><S><S><T><E><T><S><D><S><H><L><T><K><A><L><S><T><F><I><H><A><E><D><F><A><R><R><R><K><R><S><V><S><L>
Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.<BOP>
P49685
P06746
DPOLB_HUMAN
DNA polymerase beta
Homo
<M><S><K><R><K><A><P><Q><E><T><L><N><G><G><I><T><D><M><L><T><E><L><A><N><F><E><K><N><V><S><Q><A><I><H><K><Y><N><A><Y><R><K><A><A><S><V><I><A><K><Y><P><H><K><I><K><S><G><A><E><A><K><K><L><P><G><V><G><T><K><I><A><E><K><I><D><E><F><L><A><T><G><K><L><R><K><L><E><K><I><R><Q><D><D><T><S><S><S><I><N><F><L><T><R><V><S><G><I><G><P><S><A><A><R><K><F><V><D><E><G><I><K><T><L><E><D><L><R><K><N><E><D><K><L><N><H><H><Q><R><I><G><L><K><Y><F><G><D><F><E><K><R><I><P><R><E><E><M><L><Q><M><Q><D><I><V><L><N><E><V><K><K><V><D><S><E><Y><I><A><T><V><C><G><S><F><R><R><G><A><E><S><S><G><D><M><D><V><L><L><T><H><P><S><F><T><S><E><S><T><K><Q><P><K><L><L><H><Q><V><V><E><Q><L><Q><K><V><H><F><I><T><D><T><L><S><K><G><E><T><K><F><M><G><V><C><Q><L><P><S><K><N><D><E><K><E><Y><P><H><R><R><I><D><I><R><L><I><P><K><D><Q><Y><Y><C><G><V><L><Y><F><T><G><S><D><I><F><N><K><N><M><R><A><H><A><L><E><K><G><F><T><I><N><E><Y><T><I><R><P><L><G><V><T><G><V><A><G><E><P><L><P><V><D><S><E><K><D><I><F><D><Y><I><Q><W><K><Y><R><E><P><K><D><R><S><E>
Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<BOP>
P06746
Q9Y305
ACOT9_HUMAN
Acyl-CoA thioester hydrolase 9
Homo
<M><R><R><A><A><L><R><L><C><A><L><G><K><G><Q><L><T><P><G><R><G><L><T><Q><G><P><Q><N><P><K><K><Q><G><I><F><H><I><H><E><V><R><D><K><L><R><E><I><V><G><A><S><T><N><W><R><D><H><V><K><A><M><E><E><R><K><L><L><H><S><F><L><A><K><S><Q><D><G><L><P><P><R><R><M><K><D><S><Y><I><E><V><L><L><P><L><G><S><E><P><E><L><R><E><K><Y><L><T><V><Q><N><T><V><R><F><G><R><I><L><E><D><L><D><S><L><G><V><L><I><C><Y><M><H><N><K><I><H><S><A><K><M><S><P><L><S><I><V><T><A><L><V><D><K><I><D><M><C><K><K><S><L><S><P><E><Q><D><I><K><F><S><G><H><V><S><W><V><G><K><T><S><M><E><V><K><M><Q><M><F><Q><L><H><G><D><E><F><C><P><V><L><D><A><T><F><V><M><V><A><R><D><S><E><N><K><G><P><A><F><V><N><P><L><I><P><E><S><P><E><E><E><E><L><F><R><Q><G><E><L><N><K><G><R><R><I><A><F><S><S><T><S><L><L><K><M><A><P><S><A><E><E><R><T><T><I><H><E><M><F><L><S><T><L><D><P><K><T><I><S><F><R><S><R><V><L><P><S><N><A><V><W><M><E><N><S><K><L><K><S><L><E><I><C><H><P><Q><E><R><N><I><F><N><R><I><F><G><G><F><L><M><R><K><A><Y><E><L><A><W><A><T><A><C><S><F><G><G><S><R><P><F><V><V><A><V><D><D><I><M><F><Q><K><P><V><E><V><G><S><L><L><F><L><S><S><Q><V><C><F><T><Q><N><N><Y><I><Q><V><R><V><H><S><E><V><A><S><L><Q><E><K><Q><H><T><T><T><N><V><F><H><F><T><F><M><S><E><K><E><V><P><L><V><F><P><K><T><Y><G><E><S><M><L><Y><L><D><G><Q><R><H><F><N><S><M><S><G><P><A><T><L><R><K><D><Y><L><V><E><P>
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs.<BOP>
Q9Y305
A8MZ26
EFCB9_HUMAN
EF-hand calcium-binding domain-containing protein 9
Homo
<M><R><L><K><Q><G><S><F><L><W><Y><L><Y><L><D><K><I><Y><C><L><L><S><V><R><N><V><K><A><L><A><E><Y><F><H><I><L><D><V><H><G><K><N><T><L><N><D><V><L><F><Y><H><F><L><H><H><V><T><D><L><K><K><A><Q><I><N><I><V><F><D><M><L><D><W><N><A><V><G><E><I><D><F><E><K><F><Y><M><L><V><C><M><L><L><A><H><Q><N><H><L><E><G><Q><F><M><Y><R><H><S><R><P><V><F><D><L><L><D><L><K><G><D><L><R><I><G><A><K><N><F><E><M><Y><R><F><L><F><N><I><Q><K><Q><E><L><K><D><L><F><R><D><F><D><I><T><G><D><N><R><L><N><Y><Q><E><F><K><L><Y><T><I><I><Y><T><D><K><L><Q><K><R><Q><K><T><E><E><K><E><K><G><E><R><K><R><S><L><Y><S><K><C><H><I><K>
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. pH-dependent Ca(2+) sensor required to activate the CatSper channel. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+). Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel.<BOP>
A8MZ26
Q9UBQ7
GRHPR_HUMAN
Glyoxylate reductase/hydroxypyruvate reductase
Homo
<M><R><P><V><R><L><M><K><V><F><V><T><R><R><I><P><A><E><G><R><V><A><L><A><R><A><A><D><C><E><V><E><Q><W><D><S><D><E><P><I><P><A><K><E><L><E><R><G><V><A><G><A><H><G><L><L><C><L><L><S><D><H><V><D><K><R><I><L><D><A><A><G><A><N><L><K><V><I><S><T><M><S><V><G><I><D><H><L><A><L><D><E><I><K><K><R><G><I><R><V><G><Y><T><P><D><V><L><T><D><T><T><A><E><L><A><V><S><L><L><L><T><T><C><R><R><L><P><E><A><I><E><E><V><K><N><G><G><W><T><S><W><K><P><L><W><L><C><G><Y><G><L><T><Q><S><T><V><G><I><I><G><L><G><R><I><G><Q><A><I><A><R><R><L><K><P><F><G><V><Q><R><F><L><Y><T><G><R><Q><P><R><P><E><E><A><A><E><F><Q><A><E><F><V><S><T><P><E><L><A><A><Q><S><D><F><I><V><V><A><C><S><L><T><P><A><T><E><G><L><C><N><K><D><F><F><Q><K><M><K><E><T><A><V><F><I><N><I><S><R><G><D><V><V><N><Q><D><D><L><Y><Q><A><L><A><S><G><K><I><A><A><A><G><L><D><V><T><S><P><E><P><L><P><T><N><H><P><L><L><T><L><K><N><C><V><I><L><P><H><I><G><S><A><T><H><R><T><R><N><T><M><S><L><L><A><A><N><N><L><L><A><G><L><R><G><E><P><M><P><S><E><L><K><L>
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate, oxidizes D-glycerate to hydroxypyruvate.<BOP>
Q9UBQ7
Q5XG92
EST4A_HUMAN
Carboxylesterase 4A
Homo
<M><R><W><I><L><C><W><S><L><T><L><C><L><M><A><Q><T><A><L><G><A><L><H><T><K><R><P><Q><V><V><T><K><Y><G><T><L><Q><G><K><Q><M><H><V><G><K><T><P><I><Q><V><F><L><G><V><P><F><S><R><P><P><L><G><I><L><R><F><A><P><P><E><P><P><E><P><W><K><G><I><R><D><A><T><T><Y><P><P><G><C><L><Q><E><S><W><G><Q><L><A><S><M><Y><V><S><T><R><E><R><Y><K><W><L><R><F><S><E><D><C><L><Y><L><N><V><Y><A><P><A><R><A><P><G><D><P><Q><L><P><V><M><V><W><F><P><G><G><A><F><I><V><G><A><A><S><S><Y><E><G><S><D><L><A><A><R><E><K><V><V><L><V><F><L><Q><H><R><L><G><I><F><G><F><L><S><T><D><D><S><H><A><R><G><N><W><G><L><L><D><Q><M><A><A><L><R><W><V><Q><E><N><I><A><A><F><G><G><D><P><G><N><V><T><L><F><G><Q><S><A><G><A><M><S><I><S><G><L><M><M><S><P><L><A><S><G><L><F><H><R><A><I><S><Q><S><G><T><A><L><F><R><L><F><I><T><S><N><P><L><K><V><A><K><K><V><A><H><L><A><G><C><N><H><N><S><T><Q><I><L><V><N><C><L><R><A><L><S><G><T><K><V><M><R><V><S><N><K><M><R><F><L><Q><L><N><F><Q><R><D><P><E><E><I><I><W><S><M><S><P><V><V><D><G><V><V><I><P><D><D><P><L><V><L><L><T><Q><G><K><V><S><S><V><P><Y><L><L><G><V><N><N><L><E><F><N><W><L><L><P><Y><I><M><K><F><P><L><N><R><Q><A><M><R><K><E><T><I><T><K><M><L><W><S><T><R><T><L><L><N><I><T><K><E><Q><V><P><L><V><V><E><E><Y><L><D><N><V><N><E><H><D><W><K><M><L><R><N><R><M><M><D><I><V><Q><D><A><T><F><V><Y><A><T><L><Q><T><A><H><Y><H><R><D><A><G><L><P><V><Y><L><Y><E><F><E><H><H><A><R><G><I><I><V><K><P><R><T><D><G><A><D><H><G><D><E><M><Y><F><L><F><G><G><P><F><A><T><G><L><S><M><G><K><E><K><A><L><S><L><Q><M><M><K><Y><W><A><N><F><A><R><T><G><N><P><N><D><G><N><L><P><C><W><P><R><Y><N><K><D><E><K><Y><L><Q><L><D><F><T><T><R><V><G><M><K><L><K><E><K><K><M><A><F><W><M><S><L><Y><Q><S><Q><R><P><E><K><Q><R><Q><F>
Probable carboxylesterase.<BOP>
Q5XG92
P50876
R144A_HUMAN
Ubiquitin-conjugating enzyme 7-interacting protein 4
Homo
<M><T><T><T><R><Y><R><P><T><W><D><L><A><L><D><P><L><V><S><C><K><L><C><L><G><E><Y><P><V><E><Q><M><T><T><I><A><Q><C><Q><C><I><F><C><T><L><C><L><K><Q><Y><V><E><L><L><I><K><E><G><L><E><T><A><I><S><C><P><D><A><A><C><P><K><Q><G><H><L><Q><E><N><E><I><E><C><M><V><A><A><E><I><M><Q><R><Y><K><K><L><Q><F><E><R><E><V><L><F><D><P><C><R><T><W><C><P><A><S><T><C><Q><A><V><C><Q><L><Q><D><V><G><L><Q><T><P><Q><P><V><Q><C><K><A><C><R><M><E><F><C><S><T><C><K><A><S><W><H><P><G><Q><G><C><P><E><T><M><P><I><T><F><L><P><G><E><T><S><A><A><F><K><M><E><E><D><D><A><P><I><K><R><C><P><K><C><K><V><Y><I><E><R><D><E><G><C><A><Q><M><M><C><K><N><C><K><H><A><F><C><W><Y><C><L><E><S><L><D><D><D><F><L><L><I><H><Y><D><K><G><P><C><R><N><K><L><G><H><S><R><A><S><V><I><W><H><R><T><Q><V><V><G><I><F><A><G><F><G><L><L><L><L><V><A><S><P><F><L><L><L><A><T><P><F><V><L><C><C><K><C><K><C><S><K><G><D><D><D><P><L><P><T>
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.<BOP>
P50876
Q16587
ZNF74_HUMAN
hZNF7
Homo
<M><E><I><P><A><P><E><P><E><K><T><A><L><S><S><Q><D><P><A><L><S><L><K><E><N><L><E><D><I><S><G><W><G><L><P><E><A><R><S><K><E><S><V><S><F><K><D><V><A><V><D><F><T><Q><E><E><W><G><Q><L><D><S><P><Q><R><A><L><Y><R><D><V><M><L><E><N><Y><Q><N><L><L><A><L><G><P><P><L><H><K><P><D><V><I><S><H><L><E><R><G><E><E><P><W><S><M><Q><R><E><V><P><R><G><P><C><P><E><W><E><L><K><A><V><P><S><Q><Q><Q><G><I><C><K><E><E><P><A><Q><E><P><I><M><E><R><P><L><G><G><A><Q><A><W><G><R><Q><A><G><A><L><Q><R><S><Q><A><A><P><W><A><P><A><P><A><M><V><W><D><V><P><V><E><E><F><P><L><R><C><P><L><F><A><Q><Q><R><V><P><E><G><G><P><L><L><D><T><R><K><N><V><Q><A><T><E><G><R><T><K><A><P><A><R><L><C><A><G><E><N><A><S><T><P><S><E><P><E><K><F><P><Q><V><R><R><Q><R><G><A><G><A><G><E><G><E><F><V><C><G><E><C><G><K><A><F><R><Q><S><S><S><L><T><L><H><R><R><W><H><S><R><E><K><A><Y><K><C><D><E><C><G><K><A><F><T><W><S><T><N><L><L><E><H><R><R><I><H><T><G><E><K><P><F><F><C><G><E><C><G><K><A><F><S><C><H><S><S><L><N><V><H><Q><R><I><H><T><G><E><R><P><Y><K><C><S><A><C><E><K><A><F><S><C><S><S><L><L><S><M><H><L><R><V><H><T><G><E><K><P><Y><R><C><G><E><C><G><K><A><F><N><Q><R><T><H><L><T><R><H><H><R><I><H><T><G><E><K><P><Y><Q><C><G><S><C><G><K><A><F><T><C><H><S><S><L><T><V><H><E><K><I><H><S><G><D><K><P><F><K><C><S><D><C><E><K><A><F><N><S><R><S><R><L><T><L><H><Q><R><T><H><T><G><E><K><P><F><K><C><A><D><C><G><K><G><F><S><C><H><A><Y><L><L><V><H><R><R><I><H><S><G><E><K><P><F><K><C><N><E><C><G><K><A><F><S><S><H><A><Y><L><I><V><H><R><R><I><H><T><G><E><K><P><F><D><C><S><Q><C><W><K><A><F><S><C><H><S><S><L><I><V><H><Q><R><I><H><T><G><E><K><P><Y><K><C><S><E><C><G><R><A><F><S><Q><N><H><C><L><I><K><H><Q><K><I><H><S><G><E><K><S><F><K><C><E><K><C><G><E><M><F><N><W><S><S><H><L><T><E><H><Q><R><L><H><S><E><G><K><P><L><A><I><Q><F><N><K><H><L><L><S><T><Y><Y><V><P><G><S><L><L><G><A><G><D><A><G><L><R><D><V><D><P><I><D><A><L><D><V><A><K><L><L><C><V><V><P><P><R><A><G><R><N><F><S><L><G><S><K><P><R><N>
May play a role in RNA metabolism.<BOP>
Q16587
Q02078
MEF2A_HUMAN
Serum response factor-like protein 1
Homo
<M><G><R><K><K><I><Q><I><T><R><I><M><D><E><R><N><R><Q><V><T><F><T><K><R><K><F><G><L><M><K><K><A><Y><E><L><S><V><L><C><D><C><E><I><A><L><I><I><F><N><S><S><N><K><L><F><Q><Y><A><S><T><D><M><D><K><V><L><L><K><Y><T><E><Y><N><E><P><H><E><S><R><T><N><S><D><I><V><E><A><L><N><K><K><E><H><R><G><C><D><S><P><D><P><D><T><S><Y><V><L><T><P><H><T><E><E><K><Y><K><K><I><N><E><E><F><D><N><M><M><R><N><H><K><I><A><P><G><L><P><P><Q><N><F><S><M><S><V><T><V><P><V><T><S><P><N><A><L><S><Y><T><N><P><G><S><S><L><V><S><P><S><L><A><A><S><S><T><L><T><D><S><S><M><L><S><P><P><Q><T><T><L><H><R><N><V><S><P><G><A><P><Q><R><P><P><S><T><G><N><A><G><G><M><L><S><T><T><D><L><T><V><P><N><G><A><G><S><S><P><V><G><N><G><F><V><N><S><R><A><S><P><N><L><I><G><A><T><G><A><N><S><L><G><K><V><M><P><T><K><S><P><P><P><P><G><G><G><N><L><G><M><N><S><R><K><P><D><L><R><V><V><I><P><P><S><S><K><G><M><M><P><P><L><S><E><E><E><E><L><E><L><N><T><Q><R><I><S><S><S><Q><A><T><Q><P><L><A><T><P><V><V><S><V><T><T><P><S><L><P><P><Q><G><L><V><Y><S><A><M><P><T><A><Y><N><T><D><Y><S><L><T><S><A><D><L><S><A><L><Q><G><F><N><S><P><G><M><L><S><L><G><Q><V><S><A><W><Q><Q><H><H><L><G><Q><A><A><L><S><S><L><V><A><G><G><Q><L><S><Q><G><S><N><L><S><I><N><T><N><Q><N><I><S><I><K><S><E><P><I><S><P><P><R><D><R><M><T><P><S><G><F><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><P><P><P><P><P><Q><P><Q><P><Q><P><P><Q><P><Q><P><R><Q><E><M><G><R><S><P><V><D><S><L><S><S><S><S><S><S><Y><D><G><S><D><R><E><D><P><R><G><D><F><H><S><P><I><V><L><G><R><P><P><N><T><E><D><R><E><S><P><S><V><K><R><M><R><M><D><A><W><V><T>
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.<BOP>
Q02078
Q3ZCW2
LEGL_HUMAN
Lectin galactoside-binding-like protein
Homo
<M><A><G><S><V><A><D><S><D><A><V><V><K><L><D><D><G><H><L><N><N><S><L><S><S><P><V><Q><A><D><V><Y><F><P><R><L><I><V><P><F><C><G><H><I><K><G><G><M><R><P><G><K><K><V><L><V><M><G><I><V><D><L><N><P><E><S><F><A><I><S><L><T><C><G><D><S><E><D><P><P><A><D><V><A><I><E><L><K><A><V><F><T><D><R><Q><L><L><R><N><S><C><I><S><G><E><R><G><E><E><Q><S><A><I><P><Y><F><P><F><I><P><D><Q><P><F><R><V><E><I><L><C><E><H><P><R><F><R><V><F><V><D><G><H><Q><L><F><D><F><Y><H><R><I><Q><T><L><S><A><I><D><T><I><K><I><N><G><D><L><Q><I><T><K><L><G>
Does not bind lactose, and may not bind carbohydrates.<BOP>
Q3ZCW2
Q9Y5I7
CLD16_HUMAN
Paracellin-1
Homo
<M><R><D><L><L><Q><Y><I><A><C><F><F><A><F><F><S><A><G><F><L><I><V><A><T><W><T><D><C><W><M><V><N><A><D><D><S><L><E><V><S><T><K><C><R><G><L><W><W><E><C><V><T><N><A><F><D><G><I><R><T><C><D><E><Y><D><S><I><L><A><E><H><P><L><K><L><V><V><T><R><A><L><M><I><T><A><D><I><L><A><G><F><G><F><L><T><L><L><L><G><L><D><C><V><K><F><L><P><D><E><P><Y><I><K><V><R><I><C><F><V><A><G><A><T><L><L><I><A><G><T><P><G><I><I><G><S><V><W><Y><A><V><D><V><Y><V><E><R><S><T><L><V><L><H><N><I><F><L><G><I><Q><Y><K><F><G><W><S><C><W><L><G><M><A><G><S><L><G><C><F><L><A><G><A><V><L><T><C><C><L><Y><L><F><K><D><V><G><P><E><R><N><Y><P><Y><S><L><R><K><A><Y><S><A><A><G><V><S><M><A><K><S><Y><S><A><P><R><T><E><T><A><K><M><Y><A><V><D><T><R><V>
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.<BOP>
Q9Y5I7
Q15760
GPR19_HUMAN
GPR-NGA
Homo
<M><V><F><A><H><R><M><D><N><S><K><P><H><L><I><I><P><T><L><L><V><P><L><Q><N><R><S><C><T><E><T><A><T><P><L><P><S><Q><Y><L><M><E><L><S><E><E><H><S><W><M><S><N><Q><T><D><L><H><Y><V><L><K><P><G><E><V><A><T><A><S><I><F><F><G><I><L><W><L><F><S><I><F><G><N><S><L><V><C><L><V><I><H><R><S><R><R><T><Q><S><T><T><N><Y><F><V><V><S><M><A><C><A><D><L><L><I><S><V><A><S><T><P><F><V><L><L><Q><F><T><T><G><R><W><T><L><G><S><A><T><C><K><V><V><R><Y><F><Q><Y><L><T><P><G><V><Q><I><Y><V><L><L><S><I><C><I><D><R><F><Y><T><I><V><Y><P><L><S><F><K><V><S><R><E><K><A><K><K><M><I><A><A><S><W><V><F><D><A><G><F><V><T><P><V><L><F><F><Y><G><S><N><W><D><S><H><C><N><Y><F><L><P><S><S><W><E><G><T><A><Y><T><V><I><H><F><L><V><G><F><V><I><P><S><V><L><I><I><L><F><Y><Q><K><V><I><K><Y><I><W><R><I><G><T><D><G><R><T><V><R><R><T><M><N><I><V><P><R><T><K><V><K><T><I><K><M><F><L><I><L><N><L><L><F><L><L><S><W><L><P><F><H><V><A><Q><L><W><H><P><H><E><Q><D><Y><K><K><S><S><L><V><F><T><A><I><T><W><I><S><F><S><S><S><A><S><K><P><T><L><Y><S><I><Y><N><A><N><F><R><R><G><M><K><E><T><F><C><M><S><S><M><K><C><Y><R><S><N><A><Y><T><I><T><T><S><S><R><M><A><K><K><N><Y><V><G><I><S><E><I><P><S><M><A><K><T><I><T><K><D><S><I><Y><D><S><F><D><R><E><A><K><E><K><K><L><A><W><P><I><N><S><N><P><P><N><T><F><V>
Orphan receptor.<BOP>
Q15760
Q9H2S6
TNMD_HUMAN
Tendin
Homo
<M><A><K><N><P><P><E><N><C><E><D><C><H><I><L><N><A><E><A><F><K><S><K><K><I><C><K><S><L><K><I><C><G><L><V><F><G><I><L><A><L><T><L><I><V><L><F><W><G><S><K><H><F><W><P><E><V><P><K><K><A><Y><D><M><E><H><T><F><Y><S><N><G><E><K><K><K><I><Y><M><E><I><D><P><V><T><R><T><E><I><F><R><S><G><N><G><T><D><E><T><L><E><V><H><D><F><K><N><G><Y><T><G><I><Y><F><V><G><L><Q><K><C><F><I><K><T><Q><I><K><V><I><P><E><F><S><E><P><E><E><E><I><D><E><N><E><E><I><T><T><T><F><F><E><Q><S><V><I><W><V><P><A><E><K><P><I><E><N><R><D><F><L><K><N><S><K><I><L><E><I><C><D><N><V><T><M><Y><W><I><N><P><T><L><I><S><V><S><E><L><Q><D><F><E><E><E><G><E><D><L><H><F><P><A><N><E><K><K><G><I><E><Q><N><E><Q><W><V><V><P><Q><V><K><V><E><K><T><R><H><A><R><Q><A><S><E><E><E><L><P><I><N><D><Y><T><E><N><G><I><E><F><D><P><M><L><D><E><R><G><Y><C><C><I><Y><C><R><R><G><N><R><Y><C><R><R><V><C><E><P><L><L><G><Y><Y><P><Y><P><Y><C><Y><Q><G><G><R><V><I><C><R><V><I><M><P><C><N><W><W><V><A><R><M><L><G><R><V>
May be an angiogenesis inhibitor.<BOP>
Q9H2S6
P01213
PDYN_HUMAN
Dynorphin B-29
Homo
<M><A><W><Q><G><L><V><L><A><A><C><L><L><M><F><P><S><T><T><A><D><C><L><S><R><C><S><L><C><A><V><K><T><Q><D><G><P><K><P><I><N><P><L><I><C><S><L><Q><C><Q><A><A><L><L><P><S><E><E><W><E><R><C><Q><S><F><L><S><F><F><T><P><S><T><L><G><L><N><D><K><E><D><L><G><S><K><S><V><G><E><G><P><Y><S><E><L><A><K><L><S><G><S><F><L><K><E><L><E><K><S><K><F><L><P><S><I><S><T><K><E><N><T><L><S><K><S><L><E><E><K><L><R><G><L><S><D><G><F><R><E><G><A><E><S><E><L><M><R><D><A><Q><L><N><D><G><A><M><E><T><G><T><L><Y><L><A><E><E><D><P><K><E><Q><V><K><R><Y><G><G><F><L><R><K><Y><P><K><R><S><S><E><V><A><G><E><G><D><G><D><S><M><G><H><E><D><L><Y><K><R><Y><G><G><F><L><R><R><I><R><P><K><L><K><W><D><N><Q><K><R><Y><G><G><F><L><R><R><Q><F><K><V><V><T><R><S><Q><E><D><P><N><A><Y><S><G><E><L><F><D><A>
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.<BOP>
P01213
Q9BX82
ZN471_HUMAN
EZFIT-related protein 1
Homo
<M><N><V><E><V><V><K><V><M><P><Q><D><L><V><T><F><K><D><V><A><I><D><F><S><Q><E><E><W><Q><W><M><N><P><A><Q><K><R><L><Y><R><S><M><M><L><E><N><Y><Q><S><L><V><S><L><G><L><C><I><S><K><P><Y><V><I><S><L><L><E><Q><G><R><E><P><W><E><M><T><S><E><M><T><R><S><P><F><S><D><W><E><S><I><Y><V><T><Q><E><L><P><L><K><Q><F><M><Y><D><D><A><C><M><E><G><I><T><S><Y><G><L><E><C><S><T><F><E><E><N><W><K><W><E><D><L><F><E><K><Q><M><G><S><H><E><M><F><S><K><K><E><I><I><T><H><K><E><T><I><T><K><E><T><E><F><K><Y><T><K><F><G><K><C><I><H><L><E><N><I><E><E><S><I><Y><N><H><T><S><D><K><K><S><F><S><K><N><S><M><V><I><K><H><K><K><V><Y><V><G><K><K><L><F><K><C><N><E><C><D><K><T><F><T><H><S><S><S><L><T><V><H><F><R><I><H><T><G><E><K><P><Y><A><C><E><E><C><G><K><A><F><K><Q><R><Q><H><L><A><Q><H><H><R><T><H><T><G><E><K><L><F><E><C><K><E><C><R><K><A><F><K><Q><S><E><H><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><K><E><C><R><K><A><F><R><Q><P><A><H><L><A><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><D><G><S><S><F><A><R><H><Q><R><C><H><T><G><K><R><P><Y><E><C><I><E><C><G><K><A><F><R><Y><N><T><S><F><I><R><H><W><R><S><Y><H><T><G><E><K><P><F><N><C><I><D><C><G><K><A><F><S><V><H><I><G><L><I><L><H><R><R><I><H><T><G><E><K><P><Y><K><C><G><V><C><G><K><T><F><S><S><G><S><S><R><T><V><H><Q><R><I><H><T><G><E><K><P><Y><E><C><D><I><C><G><K><D><F><S><H><H><A><S><L><T><Q><H><Q><R><V><H><S><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><Q><N><V><H><L><V><S><H><L><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><I><S><S><Q><L><A><T><H><Q><R><I><H><T><G><E><K><P><Y><E><C><I><E><C><G><N><A><F><K><Q><R><S><H><L><A><Q><H><Q><K><T><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><S><Q><T><S><N><L><T><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><T><E><C><G><K><A><F><S><D><S><S><S><C><A><Q><H><Q><R><L><H><T><G><Q><R><P><Y><Q><C><F><E><C><G><K><A><F><R><R><K><L><S><L><I><C><H><Q><R><S><H><T><G><E><E><P>
May be involved in transcriptional regulation.<BOP>
Q9BX82
Q96L92
SNX27_HUMAN
Sorting nexin-27
Homo
<M><A><D><E><D><G><E><G><I><H><P><S><A><P><H><R><N><G><G><G><G><G><G><G><G><S><G><L><H><C><A><G><N><G><G><G><G><G><G><G><P><R><V><V><R><I><V><K><S><E><S><G><Y><G><F><N><V><R><G><Q><V><S><E><G><G><Q><L><R><S><I><N><G><E><L><Y><A><P><L><Q><H><V><S><A><V><L><P><G><G><A><A><D><R><A><G><V><R><K><G><D><R><I><L><E><V><N><H><V><N><V><E><G><A><T><H><K><Q><V><V><D><L><I><R><A><G><E><K><E><L><I><L><T><V><L><S><V><P><P><H><E><A><D><N><L><D><P><S><D><D><S><L><G><Q><S><F><Y><D><Y><T><E><K><Q><A><V><P><I><S><V><P><R><Y><K><H><V><E><Q><N><G><E><K><F><V><V><Y><N><V><Y><M><A><G><R><Q><L><C><S><K><R><Y><R><E><F><A><I><L><H><Q><N><L><K><R><E><F><A><N><F><T><F><P><R><L><P><G><K><W><P><F><S><L><S><E><Q><Q><L><D><A><R><R><R><G><L><E><E><Y><L><E><K><V><C><S><I><R><V><I><G><E><S><D><I><M><Q><E><F><L><S><E><S><D><E><N><Y><N><G><V><S><D><V><E><L><R><V><A><L><P><D><G><T><T><V><T><V><R><V><K><K><N><S><T><T><D><Q><V><Y><Q><A><I><A><A><K><V><G><M><D><S><T><T><V><N><Y><F><A><L><F><E><V><I><S><H><S><F><V><R><K><L><A><P><N><E><F><P><H><K><L><Y><I><Q><N><Y><T><S><A><V><P><G><T><C><L><T><I><R><K><W><L><F><T><T><E><E><E><I><L><L><N><D><N><D><L><A><V><T><Y><F><F><H><Q><A><V><D><D><V><K><K><G><Y><I><K><A><E><E><K><S><Y><Q><L><Q><K><L><Y><E><Q><R><K><M><V><M><Y><L><N><M><L><R><T><C><E><G><Y><N><E><I><I><F><P><H><C><A><C><D><S><R><R><K><G><H><V><I><T><A><I><S><I><T><H><F><K><L><H><A><C><T><E><E><G><Q><L><E><N><Q><V><I><A><F><E><W><D><E><M><Q><R><W><D><T><D><E><E><G><M><A><F><C><F><E><Y><A><R><G><E><K><K><P><R><W><V><K><I><F><T><P><Y><F><N><Y><M><H><E><C><F><E><R><V><F><C><E><L><K><W><R><K><E><N><I><F><Q><M><A><R><S><Q><Q><R><D><V><A><T>
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.<BOP>
Q96L92
Q8NA42
ZN383_HUMAN
Zinc finger protein 383
Homo
<M><A><E><G><S><V><M><F><S><D><V><S><I><D><F><S><Q><E><E><W><D><C><L><D><P><V><Q><R><D><L><Y><R><D><V><M><L><E><N><Y><G><N><L><V><S><M><G><L><Y><T><P><K><P><Q><V><I><S><L><L><E><Q><G><K><E><P><W><M><V><G><R><E><L><T><R><G><L><C><S><D><L><E><S><M><C><E><T><K><L><L><S><L><K><K><E><V><Y><E><I><E><L><C><Q><R><E><I><M><G><L><T><K><H><G><L><E><Y><S><S><F><G><D><V><L><E><Y><R><S><H><L><A><K><Q><L><G><Y><P><N><G><H><F><S><Q><E><I><F><T><P><E><Y><M><P><T><F><I><Q><Q><T><F><L><T><L><H><Q><I><I><N><N><E><D><R><P><Y><E><C><K><K><C><G><K><A><F><S><Q><N><S><Q><F><I><Q><H><Q><R><I><H><I><G><E><K><S><Y><E><C><K><E><C><G><K><F><F><S><C><G><S><H><V><T><R><H><L><K><I><H><T><G><E><K><P><F><E><C><K><E><C><G><K><A><F><S><C><S><S><Y><L><S><Q><H><Q><R><I><H><T><G><K><K><P><Y><E><C><K><E><C><G><K><A><F><S><Y><C><S><N><L><I><D><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><V><C><G><K><A><F><T><K><S><S><Q><L><F><Q><H><A><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><T><Q><S><S><K><L><V><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><S><G><S><A><L><T><N><H><Q><R><I><H><T><G><E><K><P><Y><D><C><K><E><C><G><K><A><F><T><Q><S><S><Q><L><R><Q><H><Q><R><I><H><A><G><E><K><P><F><E><C><L><E><C><G><K><A><F><T><Q><N><S><Q><L><F><Q><H><Q><R><I><H><T><D><E><K><P><Y><E><C><N><E><C><G><K><A><F><N><K><C><S><N><L><T><R><H><L><R><I><H><T><G><E><K><P><Y><N><C><K><E><C><G><K><A><F><S><S><G><S><D><L><I><R><H><Q><G><I><H><T><N><K>
May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.<BOP>
Q8NA42
Q8IUB5
WFD13_HUMAN
WAP four-disulfide core domain protein 13
Homo
<M><K><P><V><L><P><L><Q><F><L><V><V><F><C><L><A><L><Q><L><V><P><G><S><P><K><Q><R><V><L><K><Y><I><L><E><P><P><P><C><I><S><A><P><E><N><C><T><H><L><C><T><M><Q><E><D><C><E><K><G><F><Q><C><C><S><S><F><C><G><I><V><C><S><S><E><T><F><Q><K><R><N><R><I><K><H><K><G><S><E><V><I><M><P><A><N>
Putative acid-stable proteinase inhibitor.<BOP>
Q8IUB5
P17050
NAGAB_HUMAN
Alpha-galactosidase B
Homo
<M><L><L><K><T><V><L><L><L><G><H><V><A><Q><V><L><M><L><D><N><G><L><L><Q><T><P><P><M><G><W><L><A><W><E><R><F><R><C><N><I><N><C><D><E><D><P><K><N><C><I><S><E><Q><L><F><M><E><M><A><D><R><M><A><Q><D><G><W><R><D><M><G><Y><T><Y><L><N><I><D><D><C><W><I><G><G><R><D><A><S><G><R><L><M><P><D><P><K><R><F><P><H><G><I><P><F><L><A><D><Y><V><H><S><L><G><L><K><L><G><I><Y><A><D><M><G><N><F><T><C><M><G><Y><P><G><T><T><L><D><K><V><V><Q><D><A><Q><T><F><A><E><W><K><V><D><M><L><K><L><D><G><C><F><S><T><P><E><E><R><A><Q><G><Y><P><K><M><A><A><A><L><N><A><T><G><R><P><I><A><F><S><C><S><W><P><A><Y><E><G><G><L><P><P><R><V><N><Y><S><L><L><A><D><I><C><N><L><W><R><N><Y><D><D><I><Q><D><S><W><W><S><V><L><S><I><L><N><W><F><V><E><H><Q><D><I><L><Q><P><V><A><G><P><G><H><W><N><D><P><D><M><L><L><I><G><N><F><G><L><S><L><E><Q><S><R><A><Q><M><A><L><W><T><V><L><A><A><P><L><L><M><S><T><D><L><R><T><I><S><A><Q><N><M><D><I><L><Q><N><P><L><M><I><K><I><N><Q><D><P><L><G><I><Q><G><R><R><I><H><K><E><K><S><L><I><E><V><Y><M><R><P><L><S><N><K><A><S><A><L><V><F><F><S><C><R><T><D><M><P><Y><R><Y><H><S><S><L><G><Q><L><N><F><T><G><S><V><I><Y><E><A><Q><D><V><Y><S><G><D><I><I><S><G><L><R><D><E><T><N><F><T><V><I><I><N><P><S><G><V><V><M><W><Y><L><Y><P><I><K><N><L><E><M><S><Q><Q>
Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids.<BOP>
P17050
Q99541
PLIN2_HUMAN
Adipose differentiation-related protein
Homo
<M><A><S><V><A><V><D><P><Q><P><S><V><V><T><R><V><V><N><L><P><L><V><S><S><T><Y><D><L><M><S><S><A><Y><L><S><T><K><D><Q><Y><P><Y><L><K><S><V><C><E><M><A><E><N><G><V><K><T><I><T><S><V><A><M><T><S><A><L><P><I><I><Q><K><L><E><P><Q><I><A><V><A><N><T><Y><A><C><K><G><L><D><R><I><E><E><R><L><P><I><L><N><Q><P><S><T><Q><I><V><A><N><A><K><G><A><V><T><G><A><K><D><A><V><T><T><T><V><T><G><A><K><D><S><V><A><S><T><I><T><G><V><M><D><K><T><K><G><A><V><T><G><S><V><E><K><T><K><S><V><V><S><G><S><I><N><T><V><L><G><S><R><M><M><Q><L><V><S><S><G><V><E><N><A><L><T><K><S><E><L><L><V><E><Q><Y><L><P><L><T><E><E><E><L><E><K><E><A><K><K><V><E><G><F><D><L><V><Q><K><P><S><Y><Y><V><R><L><G><S><L><S><T><K><L><H><S><R><A><Y><Q><Q><A><L><S><R><V><K><E><A><K><Q><K><S><Q><Q><T><I><S><Q><L><H><S><T><V><H><L><I><E><F><A><R><K><N><V><Y><S><A><N><Q><K><I><Q><D><A><Q><D><K><L><Y><L><S><W><V><E><W><K><R><S><I><G><Y><D><D><T><D><E><S><H><C><A><E><H><I><E><S><R><T><L><A><I><A><R><N><L><T><Q><Q><L><Q><T><T><C><H><T><L><L><S><N><I><Q><G><V><P><Q><N><I><Q><D><Q><A><K><H><M><G><V><M><A><G><D><I><Y><S><V><F><R><N><A><A><S><F><K><E><V><S><D><S><L><L><T><S><S><K><G><Q><L><Q><K><M><K><E><S><L><D><D><V><M><D><Y><L><V><N><N><T><P><L><N><W><L><V><G><P><F><Y><P><Q><L><T><E><S><Q><N><A><Q><D><Q><G><A><E><M><D><K><S><S><Q><E><T><Q><R><S><E><H><K><T><H>
Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.<BOP>
Q99541
Q14108
SCRB2_HUMAN
Scavenger receptor class B member 2
Homo
<M><G><R><C><C><F><Y><T><A><G><T><L><S><L><L><L><L><V><T><S><V><T><L><L><V><A><R><V><F><Q><K><A><V><D><Q><S><I><E><K><K><I><V><L><R><N><G><T><E><A><F><D><S><W><E><K><P><P><L><P><V><Y><T><Q><F><Y><F><F><N><V><T><N><P><E><E><I><L><R><G><E><T><P><R><V><E><E><V><G><P><Y><T><Y><R><E><L><R><N><K><A><N><I><Q><F><G><D><N><G><T><T><I><S><A><V><S><N><K><A><Y><V><F><E><R><D><Q><S><V><G><D><P><K><I><D><L><I><R><T><L><N><I><P><V><L><T><V><I><E><W><S><Q><V><H><F><L><R><E><I><I><E><A><M><L><K><A><Y><Q><Q><K><L><F><V><T><H><T><V><D><E><L><L><W><G><Y><K><D><E><I><L><S><L><I><H><V><F><R><P><D><I><S><P><Y><F><G><L><F><Y><E><K><N><G><T><N><D><G><D><Y><V><F><L><T><G><E><D><S><Y><L><N><F><T><K><I><V><E><W><N><G><K><T><S><L><D><W><W><I><T><D><K><C><N><M><I><N><G><T><D><G><D><S><F><H><P><L><I><T><K><D><E><V><L><Y><V><F><P><S><D><F><C><R><S><V><Y><I><T><F><S><D><Y><E><S><V><Q><G><L><P><A><F><R><Y><K><V><P><A><E><I><L><A><N><T><S><D><N><A><G><F><C><I><P><E><G><N><C><L><G><S><G><V><L><N><V><S><I><C><K><N><G><A><P><I><I><M><S><F><P><H><F><Y><Q><A><D><E><R><F><V><S><A><I><E><G><M><H><P><N><Q><E><D><H><E><T><F><V><D><I><N><P><L><T><G><I><I><L><K><A><A><K><R><F><Q><I><N><I><Y><V><K><K><L><D><D><F><V><E><T><G><D><I><R><T><M><V><F><P><V><M><Y><L><N><E><S><V><H><I><D><K><E><T><A><S><R><L><K><S><M><I><N><T><T><L><I><I><T><N><I><P><Y><I><I><M><A><L><G><V><F><F><G><L><V><F><T><W><L><A><C><K><G><Q><G><S><M><D><E><G><T><A><D><E><R><A><P><L><I><R><T>
(Microbial infection) Acts as a receptor for enterovirus 71.<BOP>
Q14108
O14793
GDF8_HUMAN
Myostatin
Homo
<M><Q><K><L><Q><L><C><V><Y><I><Y><L><F><M><L><I><V><A><G><P><V><D><L><N><E><N><S><E><Q><K><E><N><V><E><K><E><G><L><C><N><A><C><T><W><R><Q><N><T><K><S><S><R><I><E><A><I><K><I><Q><I><L><S><K><L><R><L><E><T><A><P><N><I><S><K><D><V><I><R><Q><L><L><P><K><A><P><P><L><R><E><L><I><D><Q><Y><D><V><Q><R><D><D><S><S><D><G><S><L><E><D><D><D><Y><H><A><T><T><E><T><I><I><T><M><P><T><E><S><D><F><L><M><Q><V><D><G><K><P><K><C><C><F><F><K><F><S><S><K><I><Q><Y><N><K><V><V><K><A><Q><L><W><I><Y><L><R><P><V><E><T><P><T><T><V><F><V><Q><I><L><R><L><I><K><P><M><K><D><G><T><R><Y><T><G><I><R><S><L><K><L><D><M><N><P><G><T><G><I><W><Q><S><I><D><V><K><T><V><L><Q><N><W><L><K><Q><P><E><S><N><L><G><I><E><I><K><A><L><D><E><N><G><H><D><L><A><V><T><F><P><G><P><G><E><D><G><L><N><P><F><L><E><V><K><V><T><D><T><P><K><R><S><R><R><D><F><G><L><D><C><D><E><H><S><T><E><S><R><C><C><R><Y><P><L><T><V><D><F><E><A><F><G><W><D><W><I><I><A><P><K><R><Y><K><A><N><Y><C><S><G><E><C><E><F><V><F><L><Q><K><Y><P><H><T><H><L><V><H><Q><A><N><P><R><G><S><A><G><P><C><C><T><P><T><K><M><S><P><I><N><M><L><Y><F><N><G><K><E><Q><I><I><Y><G><K><I><P><A><M><V><V><D><R><C><G><C><S>
Acts specifically as a negative regulator of skeletal muscle growth.<BOP>
O14793
Q9UJX0
OSGI1_HUMAN
Pregnancy-induced growth inhibitor OKL38
Homo
<M><S><S><S><R><K><D><H><L><G><A><S><S><S><E><P><L><P><V><I><I><V><G><N><G><P><S><G><I><C><L><S><Y><L><L><S><G><Y><T><P><Y><T><K><P><D><A><I><H><P><H><P><L><L><Q><R><K><L><T><E><A><P><G><V><S><I><L><D><Q><D><L><D><Y><L><S><E><G><L><E><G><R><S><Q><S><P><V><A><L><L><F><D><A><L><L><R><P><D><T><D><F><G><G><N><M><K><S><V><L><T><W><K><H><R><K><E><H><A><I><P><H><V><V><L><G><R><N><L><P><G><G><A><W><H><S><I><E><G><S><M><V><I><L><S><Q><G><Q><W><M><G><L><P><D><L><E><V><K><D><W><M><Q><K><K><R><R><G><L><R><N><S><R><A><T><A><G><D><I><A><H><Y><Y><R><D><Y><V><V><K><K><G><L><G><H><N><F><V><S><G><A><V><V><T><A><V><E><W><G><T><P><D><P><S><S><C><G><A><Q><D><S><S><P><L><F><Q><V><S><G><F><L><T><R><N><Q><A><Q><Q><P><F><S><L><W><A><R><N><V><V><L><A><T><G><T><F><D><S><P><A><R><L><G><I><P><G><E><A><L><P><F><I><H><H><E><L><S><A><L><E><A><A><T><R><V><G><A><V><T><P><A><S><D><P><V><L><I><I><G><A><G><L><S><A><A><D><A><V><L><Y><A><R><H><Y><N><I><P><V><I><H><A><F><R><R><A><V><D><D><P><G><L><V><F><N><Q><L><P><K><M><L><Y><P><E><Y><H><K><V><H><Q><M><M><R><E><Q><S><I><L><S><P><S><P><Y><E><G><Y><R><S><L><P><R><H><Q><L><L><C><F><K><E><D><C><Q><A><V><F><Q><D><L><E><G><V><E><K><V><F><G><V><S><L><V><L><V><L><I><G><S><H><P><D><L><S><F><L><P><G><A><G><A><D><F><A><V><D><P><D><Q><P><L><S><A><K><R><N><P><I><D><V><D><P><F><T><Y><Q><S><T><R><Q><E><G><L><Y><A><M><G><P><L><A><G><D><N><F><V><R><F><V><Q><G><G><A><L><A><V><A><S><S><L><L><R><K><E><T><R><K><P><P>
Regulates the differentiation and proliferation through the regulation of cell death.<BOP>
Q9UJX0
Q6UX65
DRAM2_HUMAN
Transmembrane protein 77
Homo
<M><W><W><F><Q><Q><G><L><S><F><L><P><S><A><L><V><I><W><T><S><A><A><F><I><F><S><Y><I><T><A><V><T><L><H><H><I><D><P><A><L><P><Y><I><S><D><T><G><T><V><A><P><E><K><C><L><F><G><A><M><L><N><I><A><A><V><L><C><I><A><T><I><Y><V><R><Y><K><Q><V><H><A><L><S><P><E><E><N><V><I><I><K><L><N><K><A><G><L><V><L><G><I><L><S><C><L><G><L><S><I><V><A><N><F><Q><K><T><T><L><F><A><A><H><V><S><G><A><V><L><T><F><G><M><G><S><L><Y><M><F><V><Q><T><I><L><S><Y><Q><M><Q><P><K><I><H><G><K><Q><V><F><W><I><R><L><L><L><V><I><W><C><G><V><S><A><L><S><M><L><T><C><S><S><V><L><H><S><G><N><F><G><T><D><L><E><Q><K><L><H><W><N><P><E><D><K><G><Y><V><L><H><M><I><T><T><A><A><E><W><S><M><S><F><S><F><F><G><F><F><L><T><Y><I><R><D><F><Q><K><I><S><L><R><V><E><A><N><L><H><G><L><T><L><Y><D><T><A><P><C><P><I><N><N><E><R><T><R><L><L><S><R><D><I>
Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.<BOP>
Q6UX65
Q13352
CENPR_HUMAN
Nuclear receptor-interacting factor 3
Homo
<M><P><V><K><R><S><L><K><L><D><G><L><L><E><E><N><S><F><D><P><S><K><I><T><R><K><K><S><V><I><T><Y><S><P><T><T><G><T><C><Q><M><S><L><F><A><S><P><T><S><S><E><E><Q><K><H><R><N><G><L><S><N><E><K><R><K><K><L><N><H><P><S><L><T><E><S><K><E><S><T><T><K><D><N><D><E><F><M><M><L><L><S><K><V><E><K><L><S><E><E><I><M><E><I><M><Q><N><L><S><S><I><Q><A><L><E><G><S><R><E><L><E><N><L><I><G><I><S><C><A><S><H><F><L><K><R><E><M><Q><K><T><K><E><L><M><T><K><V><N><K><Q><K><L><F><E><K><S><T><G><L><P><H><K><A><S><R><H><L><D><S><Y><E><F><L><K><A><I><L><N>
Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with
Q13352
Q5T1C6
THEM4_HUMAN
Thioesterase superfamily member 4
Homo
<M><L><R><S><C><A><A><R><L><R><T><L><G><A><L><C><L><P><P><V><G><R><R><L><P><G><S><E><P><R><P><E><L><R><S><F><S><S><E><E><V><I><L><K><D><C><S><V><P><N><P><S><W><N><K><D><L><R><L><L><F><D><Q><F><M><K><K><C><E><D><G><S><W><K><R><L><P><S><Y><K><R><T><P><T><E><W><I><Q><D><F><K><T><H><F><L><D><P><K><L><M><K><E><E><Q><M><S><Q><A><Q><L><F><T><R><S><F><D><D><G><L><G><F><E><Y><V><M><F><Y><N><D><I><E><K><R><M><V><C><L><F><Q><G><G><P><Y><L><E><G><P><P><G><F><I><H><G><G><A><I><A><T><M><I><D><A><T><V><G><M><C><A><M><M><A><G><G><I><V><M><T><A><N><L><N><I><N><Y><K><R><P><I><P><L><C><S><V><V><M><I><N><S><Q><L><D><K><V><E><G><R><K><F><F><V><S><C><N><V><Q><S><V><D><E><K><T><L><Y><S><E><A><T><S><L><F><I><K><L><N><P><A><K><S><L><T>
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.<BOP>
Q5T1C6
Q96LL3
FIMP_HUMAN
Fertilization-influencing membrane protein
Homo
<M><G><A><G><V><G><V><A><G><C><T><R><G><H><R><N><W><V><P><S><Q><L><P><P><R><E><I><K><A><G><V><S><L><A><V><V><T><E><F><A><W><V><L><A><P><R><P><K><R><A><T><A><S><A><L><G><T><E><S><P><R><F><L><D><R><P><D><F><F><D><Y><P><D><S><D><Q><A><R><L><L><A><V><A><Q><F><I><G><E><K><P><I><V><F><I><N><S><G><S><S><P><G><L><F><H><H><I><L><V><G><L><L><V><V><A><F><F><F><L><L><F><Q><F><C><T><H><I><N><F><Q><K><G><A>
May play a role in sperm-oocyte fusion during fertilization.<BOP>
Q96LL3
P0C7M3
SFTA3_HUMAN
Surfactant-associated protein H
Homo
<M><R><A><G><F><S><D><F><Q><L><I><R><D><Q><V><L><F><L><Q><D><Q><A><Q><R><L><T><E><W><L><Q><L><S><G><F><E><N><P><V><S><E><S><T><T><L><C><L><R><E><R><E><K><R><I><P><T><C><V><A><V><C><V><P><S><P><G><T><V><H><T><A><L><L><H><P><T><T><L><S><Q><S><R><S><S><S><E><A><K><M><L><I><I><H><T><A>
Putative surfactant protein. May be involved in wound healing and in the reduction of the surface tension at the ocular surface.<BOP>
P0C7M3
A6NK75
ZNF98_HUMAN
Zinc finger protein F7175
Homo
<M><P><G><P><L><G><S><L><E><M><G><V><L><T><F><R><D><V><A><L><E><F><S><L><E><E><W><Q><C><L><D><T><A><Q><Q><N><L><Y><R><N><V><M><L><E><N><Y><R><N><L><V><F><V><G><I><A><A><S><K><P><D><L><I><T><C><L><E><Q><G><K><E><P><W><N><V><K><R><H><E><M><V><T><E><P><P><V><V><Y><S><Y><F><A><Q><D><L><W><P><K><Q><G><K><K><N><Y><F><Q><K><V><I><L><R><T><Y><K><K><C><G><R><E><N><L><Q><L><R><K><Y><C><K><S><M><D><E><C><K><V><H><K><E><C><Y><N><G><L><N><Q><C><L><T><T><T><Q><N><K><I><F><Q><Y><D><K><Y><V><K><V><F><H><K><F><S><N><S><N><R><H><K><I><G><H><T><G><K><K><S><F><K><C><K><E><C><E><K><S><F><C><M><L><S><H><L><A><Q><H><K><R><I><H><S><G><E><K><P><Y><K><C><K><E><C><G><K><A><Y><N><E><A><S><N><L><S><T><H><K><R><I><H><T><G><K><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><L><S><H><L><T><T><H><K><I><I><H><T><G><K><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><A><N><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><R><A><F><S><Q><S><S><T><L><T><A><H><K><I><I><H><A><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><S><Q><S><S><T><L><T><T><H><K><I><I><H><T><G><E><K><F><Y><K><C><E><E><C><G><K><A><F><S><R><L><S><H><L><T><T><H><K><R><I><H><S><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><Q><S><S><T><L><T><T><H><K><R><I><H><A><G><E><K><F><Y><K><C><E><V><C><S><K><A><F><S><R><F><S><H><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><L><S><S><Q><L><T><T><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><S><T><L><S><K><H><K><V><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><S><H><L><T><T><H><K><M><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><N><S><S><I><L><N><R><H><K><M><I><H><T><G><E><K><L><Y><K><P><E><S><C><N><N><A><C><D><N><I><A><K><I><S><K><Y><K><R><N><C><A><G><E><K>
May be involved in transcriptional regulation.<BOP>
A6NK75
Q8NGF1
O52R1_HUMAN
Olfactory receptor OR11-22
Homo
<M><V><L><A><S><G><N><S><S><S><H><P><V><S><F><I><L><L><G><I><P><G><L><E><S><F><Q><L><W><I><A><F><P><F><C><A><T><Y><A><V><A><V><V><G><N><I><T><L><L><H><V><I><R><I><D><H><T><L><H><E><P><M><Y><L><F><L><A><M><L><A><I><T><D><L><V><L><S><S><S><T><Q><P><K><M><L><A><I><F><W><F><H><A><H><E><I><Q><Y><H><A><C><L><I><Q><V><F><F><I><H><A><F><S><S><V><E><S><G><V><L><M><A><M><A><L><D><C><Y><V><A><I><C><F><P><L><R><H><S><S><I><L><T><P><S><V><V><I><K><L><G><T><I><V><M><L><R><G><L><L><W><V><S><P><F><C><F><M><V><S><R><M><P><F><C><Q><H><Q><A><I><P><Q><S><Y><C><E><H><M><A><V><L><K><L><V><C><A><D><T><S><I><S><R><G><N><G><L><F><V><A><F><S><V><A><G><F><D><M><I><V><I><G><M><S><Y><V><M><I><L><R><A><V><L><Q><L><P><S><G><E><A><R><L><K><A><F><S><T><R><S><S><H><I><C><V><I><L><A><L><Y><I><P><A><L><F><S><F><L><T><Y><R><F><G><H><D><V><P><R><V><V><H><I><L><F><A><N><L><Y><L><L><I><P><P><M><L><N><P><I><I><Y><G><V><R><T><K><Q><I><G><D><R><V><I><Q><G><C><C><G><N><I><P>
Odorant receptor.<BOP>
Q8NGF1
P30048
PRDX3_HUMAN
Thioredoxin-dependent peroxiredoxin 3
Homo
<M><A><A><A><V><G><R><L><L><R><A><S><V><A><R><H><V><S><A><I><P><W><G><I><S><A><T><A><A><L><R><P><A><A><C><G><R><T><S><L><T><N><L><L><C><S><G><S><S><Q><A><K><L><F><S><T><S><S><S><C><H><A><P><A><V><T><Q><H><A><P><Y><F><K><G><T><A><V><V><N><G><E><F><K><D><L><S><L><D><D><F><K><G><K><Y><L><V><L><F><F><Y><P><L><D><F><T><F><V><C><P><T><E><I><V><A><F><S><D><K><A><N><E><F><H><D><V><N><C><E><V><V><A><V><S><V><D><S><H><F><S><H><L><A><W><I><N><T><P><R><K><N><G><G><L><G><H><M><N><I><A><L><L><S><D><L><T><K><Q><I><S><R><D><Y><G><V><L><L><E><G><S><G><L><A><L><R><G><L><F><I><I><D><P><N><G><V><I><K><H><L><S><V><N><D><L><P><V><G><R><S><V><E><E><T><L><R><L><V><K><A><F><Q><Y><V><E><T><H><G><E><V><C><P><A><N><W><T><P><D><S><P><T><I><K><P><S><P><A><A><S><K><E><Y><F><Q><K><V><N><Q>
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides . Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol .<BOP>
P30048
Q9NRA2
S17A5_HUMAN
Vesicular H(+)/Aspartate-glutamate cotransporter
Homo
<M><R><S><P><V><R><D><L><A><R><N><D><G><E><E><S><T><D><R><T><P><L><L><P><G><A><P><R><A><E><A><A><P><V><C><C><S><A><R><Y><N><L><A><I><L><A><F><F><G><F><F><I><V><Y><A><L><R><V><N><L><S><V><A><L><V><D><M><V><D><S><N><T><T><L><E><D><N><R><T><S><K><A><C><P><E><H><S><A><P><I><K><V><H><H><N><Q><T><G><K><K><Y><Q><W><D><A><E><T><Q><G><W><I><L><G><S><F><F><Y><G><Y><I><I><T><Q><I><P><G><G><Y><V><A><S><K><I><G><G><K><M><L><L><G><F><G><I><L><G><T><A><V><L><T><L><F><T><P><I><A><A><D><L><G><V><G><P><L><I><V><L><R><A><L><E><G><L><G><E><G><V><T><F><P><A><M><H><A><M><W><S><S><W><A><P><P><L><E><R><S><K><L><L><S><I><S><Y><A><G><A><Q><L><G><T><V><I><S><L><P><L><S><G><I><I><C><Y><Y><M><N><W><T><Y><V><F><Y><F><F><G><T><I><G><I><F><W><F><L><L><W><I><W><L><V><S><D><T><P><Q><K><H><K><R><I><S><H><Y><E><K><E><Y><I><L><S><S><L><R><N><Q><L><S><S><Q><K><S><V><P><W><V><P><I><L><K><S><L><P><L><W><A><I><V><V><A><H><F><S><Y><N><W><T><F><Y><T><L><L><T><L><L><P><T><Y><M><K><E><I><L><R><F><N><V><Q><E><N><G><F><L><S><S><L><P><Y><L><G><S><W><L><C><M><I><L><S><G><Q><A><A><D><N><L><R><A><K><W><N><F><S><T><L><C><V><R><R><I><F><S><L><I><G><M><I><G><P><A><V><F><L><V><A><A><G><F><I><G><C><D><Y><S><L><A><V><A><F><L><T><I><S><T><T><L><G><G><F><C><S><S><G><F><S><I><N><H><L><D><I><A><P><S><Y><A><G><I><L><L><G><I><T><N><T><F><A><T><I><P><G><M><V><G><P><V><I><A><K><S><L><T><P><D><N><T><V><G><E><W><Q><T><V><F><Y><I><A><A><A><I><N><V><F><G><A><I><F><F><T><L><F><A><K><G><E><V><Q><N><W><A><L><N><D><H><H><G><H><R><H>
Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.<BOP>
Q9NRA2
P01008
ANT3_HUMAN
Serpin C1
Homo
<M><Y><S><N><V><I><G><T><V><T><S><G><K><R><K><V><Y><L><L><S><L><L><L><I><G><F><W><D><C><V><T><C><H><G><S><P><V><D><I><C><T><A><K><P><R><D><I><P><M><N><P><M><C><I><Y><R><S><P><E><K><K><A><T><E><D><E><G><S><E><Q><K><I><P><E><A><T><N><R><R><V><W><E><L><S><K><A><N><S><R><F><A><T><T><F><Y><Q><H><L><A><D><S><K><N><D><N><D><N><I><F><L><S><P><L><S><I><S><T><A><F><A><M><T><K><L><G><A><C><N><D><T><L><Q><Q><L><M><E><V><F><K><F><D><T><I><S><E><K><T><S><D><Q><I><H><F><F><F><A><K><L><N><C><R><L><Y><R><K><A><N><K><S><S><K><L><V><S><A><N><R><L><F><G><D><K><S><L><T><F><N><E><T><Y><Q><D><I><S><E><L><V><Y><G><A><K><L><Q><P><L><D><F><K><E><N><A><E><Q><S><R><A><A><I><N><K><W><V><S><N><K><T><E><G><R><I><T><D><V><I><P><S><E><A><I><N><E><L><T><V><L><V><L><V><N><T><I><Y><F><K><G><L><W><K><S><K><F><S><P><E><N><T><R><K><E><L><F><Y><K><A><D><G><E><S><C><S><A><S><M><M><Y><Q><E><G><K><F><R><Y><R><R><V><A><E><G><T><Q><V><L><E><L><P><F><K><G><D><D><I><T><M><V><L><I><L><P><K><P><E><K><S><L><A><K><V><E><K><E><L><T><P><E><V><L><Q><E><W><L><D><E><L><E><E><M><M><L><V><V><H><M><P><R><F><R><I><E><D><G><F><S><L><K><E><Q><L><Q><D><M><G><L><V><D><L><F><S><P><E><K><S><K><L><P><G><I><V><A><E><G><R><D><D><L><Y><V><S><D><A><F><H><K><A><F><L><E><V><N><E><E><G><S><E><A><A><A><S><T><A><V><V><I><A><G><R><S><L><N><P><N><R><V><T><F><K><A><N><R><P><F><L><V><F><I><R><E><V><P><L><N><T><I><I><F><M><G><R><V><A><N><P><C><V><K>
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade . AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa . Its inhibitory activity is greatly enhanced in the presence of heparin.<BOP>
P01008
P43378
PTN9_HUMAN
Protein-tyrosine phosphatase MEG2
Homo
<M><E><P><A><T><A><P><R><P><D><M><A><P><E><L><T><P><E><E><E><Q><A><T><K><Q><F><L><E><E><I><N><K><W><T><V><Q><Y><N><V><S><P><L><S><W><N><V><A><V><K><F><L><M><A><R><K><F><D><V><L><R><A><I><E><L><F><H><S><Y><R><E><T><R><R><K><E><G><I><V><K><L><K><P><H><E><E><P><L><R><S><E><I><L><S><G><K><F><T><I><L><N><V><R><D><P><T><G><A><S><I><A><L><F><T><A><R><L><H><H><P><H><K><S><V><Q><H><V><V><L><Q><A><L><F><Y><L><L><D><R><A><V><D><S><F><E><T><Q><R><N><G><L><V><F><I><Y><D><M><C><G><S><N><Y><A><N><F><E><L><D><L><G><K><K><V><L><N><L><L><K><G><A><F><P><A><R><L><K><K><V><L><I><V><G><A><P><I><W><F><R><V><P><Y><S><I><I><S><L><L><L><K><D><K><V><R><E><R><I><Q><I><L><K><T><S><E><V><T><Q><H><L><P><R><E><C><L><P><E><N><L><G><G><Y><V><K><I><D><L><A><T><W><N><F><Q><F><L><P><Q><V><N><G><H><P><D><P><F><D><E><I><I><L><F><S><L><P><P><A><L><D><W><D><S><V><H><V><P><G><P><H><A><M><T><I><Q><E><L><V><D><Y><V><N><A><R><Q><K><Q><G><I><Y><E><E><Y><E><D><I><R><R><E><N><P><V><G><T><F><H><C><S><M><S><P><G><N><L><E><K><N><R><Y><G><D><V><P><C><L><D><Q><T><R><V><K><L><T><K><R><S><G><H><T><Q><T><D><Y><I><N><A><S><F><M><D><G><Y><K><Q><K><N><A><Y><I><G><T><Q><G><P><L><E><N><T><Y><R><D><F><W><L><M><V><W><E><Q><K><V><L><V><I><V><M><T><T><R><F><E><E><G><G><R><R><K><C><G><Q><Y><W><P><L><E><K><D><S><R><I><R><F><G><F><L><T><V><T><N><L><G><V><E><N><M><N><H><Y><K><K><T><T><L><E><I><H><N><T><E><E><R><Q><K><R><Q><V><T><H><F><Q><F><L><S><W><P><D><Y><G><V><P><S><S><A><A><S><L><I><D><F><L><R><V><V><R><N><Q><Q><S><L><A><V><S><N><M><G><A><R><S><K><G><Q><C><P><E><P><P><I><V><V><H><C><S><A><G><I><G><R><T><G><T><F><C><S><L><D><I><C><L><A><Q><L><E><E><L><G><T><L><N><V><F><Q><T><V><S><R><M><R><T><Q><R><A><F><S><I><Q><T><P><E><Q><Y><Y><F><C><Y><K><A><I><L><E><F><A><E><K><E><G><M><V><S><S><G><Q><N><L><L><A><V><E><S><Q>
Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.<BOP>
P43378
O60729
CC14B_HUMAN
CDC14 cell division cycle 14 homolog B
Homo
<M><K><R><K><S><E><R><R><S><S><W><A><A><A><P><P><C><S><R><R><C><S><S><T><S><P><G><V><K><K><I><R><S><S><T><Q><Q><D><P><R><R><R><D><P><Q><D><D><V><Y><L><D><I><T><D><R><L><C><F><A><I><L><Y><S><R><P><K><S><A><S><N><V><H><Y><F><S><I><D><N><E><L><E><Y><E><N><F><Y><A><D><F><G><P><L><N><L><A><M><V><Y><R><Y><C><C><K><I><N><K><K><L><K><S><I><T><M><L><R><K><K><I><V><H><F><T><G><S><D><Q><R><K><Q><A><N><A><A><F><L><V><G><C><Y><M><V><I><Y><L><G><R><T><P><E><E><A><Y><R><I><L><I><F><G><E><T><S><Y><I><P><F><R><D><A><A><Y><G><S><C><N><F><Y><I><T><L><L><D><C><F><H><A><V><K><K><A><M><Q><Y><G><F><L><N><F><N><S><F><N><L><D><E><Y><E><H><Y><E><K><A><E><N><G><D><L><N><W><I><I><P><D><R><F><I><A><F><C><G><P><H><S><R><A><R><L><E><S><G><Y><H><Q><H><S><P><E><T><Y><I><Q><Y><F><K><N><H><N><V><T><T><I><I><R><L><N><K><R><M><Y><D><A><K><R><F><T><D><A><G><F><D><H><H><D><L><F><F><A><D><G><S><T><P><T><D><A><I><V><K><E><F><L><D><I><C><E><N><A><E><G><A><I><A><V><H><C><K><A><G><L><G><R><T><G><T><L><I><A><C><Y><I><M><K><H><Y><R><M><T><A><A><E><T><I><A><W><V><R><I><C><R><P><G><S><V><I><G><P><Q><Q><Q><F><L><V><M><K><Q><T><N><L><W><L><E><G><D><Y><F><R><Q><K><L><K><G><Q><E><N><G><Q><H><R><A><A><F><S><K><L><L><S><G><V><D><D><I><S><I><N><G><V><E><N><Q><D><Q><Q><E><P><E><P><Y><S><D><D><D><E><I><N><G><V><T><Q><G><D><R><L><R><A><L><K><S><R><R><Q><S><K><T><N><A><I><P><L><T><V><I><L><Q><S><S><V><Q><S><C><K><T><S><E><P><N><I><S><G><S><A><G><I><T><K><R><T><T><R><S><A><S><R><K><S><S><V><K><S><L><S><I><S><R><T><K><T><V><L><R>
Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.<BOP>
O60729
Q99661
KIF2C_HUMAN
Mitotic centromere-associated kinesin
Homo
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In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells . Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis . Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment .<BOP>
Q99661
Q9UII6
DS13B_HUMAN
Testis- and skeletal-muscle-specific DSP
Homo
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Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro . Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro .<BOP>
Q9UII6