Datasets:
yangzhang33
/
Prot2Text-Diff-HUMAN-func256-seq768

Dataset card Data Studio Files
xet
Community
1
accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
⌀
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q6AW86
Z324B_HUMAN
Zinc finger protein 324B
Homo
<M><T><F><E><D><V><A><V><Y><F><S><Q><E><E><W><G><L><L><D><T><A><Q><R><A><L><Y><R><H><V><M><L><E><N><F><T><L><V><T><S><L><G><L><S><T><S><R><P><R><V><V><I><Q><L><E><R><G><E><E><P><W><V><P><S><G><K><D><M><T><L><A><R><N><T><Y><G><R><L><N><S><G><S><W><S><L><T><E><D><R><D><V><S><G><E><W><P><R><A><F><P><D><T><P><P><G><M><T><T><S><V><F><P><V><A><D><A><C><H><S><V><K><S><L><Q><R><Q><P><G><A><S><P><S><Q><E><R><K><P><T><G><V><S><V><I><Y><W><E><R><L><L><L><G><S><R><S><D><Q><A><S><I><S><L><R><L><T><S><P><L><R><P><P><K><S><S><R><P><R><E><K><T><F><T><E><Y><R><V><P><G><R><Q><P><R><T><P><E><R><Q><K><P><C><A><Q><E><V><P><G><R><A><F><G><N><A><S><D><L><K><A><A><S><G><G><R><D><R><R><M><G><A><A><W><Q><E><P><H><R><L><L><G><G><Q><E><P><S><T><W><D><E><L><G><E><A><L><H><A><G><E><K><S><F><E><C><R><A><C><S><K><V><F><V><K><S><S><D><L><L><K><H><L><R><T><H><T><G><E><R><P><Y><E><C><T><Q><C><G><K><A><F><S><Q><T><S><H><L><T><Q><H><Q><R><I><H><S><G><E><T><P><Y><A><C><P><V><C><G><K><A><F><R><H><S><S><S><L><V><R><H><Q><R><I><H><T><A><E><K><S><F><R><C><S><E><C><G><K><A><F><S><H><G><S><N><L><S><Q><H><R><K><I><H><A><G><G><R><P><Y><A><C><A><Q><C><G><R><R><F><C><R><N><S><H><L><I><Q><H><E><R><T><H><T><G><E><K><P><F><V><C><A><L><C><G><A><A><F><S><Q><G><S><S><L><F><L><H><Q><R><V><H><T><G><E><K><P><F><A><C><A><Q><C><G><R><S><F><S><R><S><S><N><L><T><Q><H><Q><L><L><H><T><G><E><R><P><F><R><C><V><D><C><G><K><G><F><A><K><G><A><V><L><L><S><H><R><R><I><H><T><G><E><K><P><F><V><C><T><Q><C><G><R><A><F><R><E><R><P><A><L><L><H><H><Q><R><I><H><T><T><E><K><T><N><A><A><A><P><D><C><T><P><G><P><G><F><L><Q><G><H><H><R><K><V><R><R><G><G><K><P><S><P><V><L><K><P><A><K><V>
May be involved in transcriptional regulation.<BOP>
Q6AW86
Q14206
RCAN2_HUMAN
Thyroid hormone-responsive protein ZAKI-4
Homo
<M><P><A><P><S><M><D><C><D><V><S><T><L><V><A><C><V><V><D><V><E><V><F><T><N><Q><E><V><K><E><K><F><E><G><L><F><R><T><Y><D><D><C><V><T><F><Q><L><F><K><S><F><R><R><V><R><I><N><F><S><N><P><K><S><A><A><R><A><R><I><E><L><H><E><T><Q><F><R><G><K><K><L><K><L><Y><F><A><Q><V><Q><T><P><E><T><D><G><D><K><L><H><L><A><P><P><Q><P><A><K><Q><F><L><I><S><P><P><S><S><P><P><V><G><W><Q><P><I><N><D><A><T><P><V><L><N><Y><D><L><L><Y><A><V><A><K><L><G><P><G><E><K><Y><E><L><H><A><G><T><E><S><T><P><S><V><V><V><H><V><C><D><S><D><I><E><E><E><E><D><P><K><T><S><P><K><P><K><I><I><Q><T><R><R><P><G><L><P><P><S><V><S><N>
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.<BOP>
Q14206
P41586
PACR_HUMAN
Pituitary adenylate cyclase-activating polypeptide type I receptor
Homo
<M><A><G><V><V><H><V><S><L><A><A><L><L><L><L><P><M><A><P><A><M><H><S><D><C><I><F><K><K><E><Q><A><M><C><L><E><K><I><Q><R><A><N><E><L><M><G><F><N><D><S><S><P><G><C><P><G><M><W><D><N><I><T><C><W><K><P><A><H><V><G><E><M><V><L><V><S><C><P><E><L><F><R><I><F><N><P><D><Q><V><W><E><T><E><T><I><G><E><S><D><F><G><D><S><N><S><L><D><L><S><D><M><G><V><V><S><R><N><C><T><E><D><G><W><S><E><P><F><P><H><Y><F><D><A><C><G><F><D><E><Y><E><S><E><T><G><D><Q><D><Y><Y><Y><L><S><V><K><A><L><Y><T><V><G><Y><S><T><S><L><V><T><L><T><T><A><M><V><I><L><C><R><F><R><K><L><H><C><T><R><N><F><I><H><M><N><L><F><V><S><F><M><L><R><A><I><S><V><F><I><K><D><W><I><L><Y><A><E><Q><D><S><N><H><C><F><I><S><T><V><E><C><K><A><V><M><V><F><F><H><Y><C><V><V><S><N><Y><F><W><L><F><I><E><G><L><Y><L><F><T><L><L><V><E><T><F><F><P><E><R><R><Y><F><Y><W><Y><T><I><I><G><W><G><T><P><T><V><C><V><T><V><W><A><T><L><R><L><Y><F><D><D><T><G><C><W><D><M><N><D><S><T><A><L><W><W><V><I><K><G><P><V><V><G><S><I><M><V><N><F><V><L><F><I><G><I><I><V><I><L><V><Q><K><L><Q><S><P><D><M><G><G><N><E><S><S><I><Y><L><R><L><A><R><S><T><L><L><L><I><P><L><F><G><I><H><Y><T><V><F><A><F><S><P><E><N><V><S><K><R><E><R><L><V><F><E><L><G><L><G><S><F><Q><G><F><V><V><A><V><L><Y><C><F><L><N><G><E><V><Q><A><E><I><K><R><K><W><R><S><W><K><V><N><R><Y><F><A><V><D><F><K><H><R><H><P><S><L><A><S><S><G><V><N><G><G><T><Q><L><S><I><L><S><K><S><S><S><Q><I><R><M><S><G><L><P><A><D><N><L><A><T>
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.<BOP>
P41586
P15153
RAC2_HUMAN
p21-Rac2
Homo
<M><Q><A><I><K><C><V><V><V><G><D><G><A><V><G><K><T><C><L><L><I><S><Y><T><T><N><A><F><P><G><E><Y><I><P><T><V><F><D><N><Y><S><A><N><V><M><V><D><S><K><P><V><N><L><G><L><W><D><T><A><G><Q><E><D><Y><D><R><L><R><P><L><S><Y><P><Q><T><D><V><F><L><I><C><F><S><L><V><S><P><A><S><Y><E><N><V><R><A><K><W><F><P><E><V><R><H><H><C><P><S><T><P><I><I><L><V><G><T><K><L><D><L><R><D><D><K><D><T><I><E><K><L><K><E><K><K><L><A><P><I><T><Y><P><Q><G><L><A><L><A><K><E><I><D><S><V><K><Y><L><E><C><S><A><L><T><Q><R><G><L><K><T><V><F><D><E><A><I><R><A><V><L><C><P><Q><P><T><R><Q><Q><K><R><A><C><S><L><L>
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.<BOP>
P15153
Q8WYN0
ATG4A_HUMAN
Autophagy-related protein 4 homolog A
Homo
<M><E><S><V><L><S><K><Y><E><D><Q><I><T><I><F><T><D><Y><L><E><E><Y><P><D><T><D><E><L><V><W><I><L><G><K><Q><H><L><L><K><T><E><K><S><K><L><L><S><D><I><S><A><R><L><W><F><T><Y><R><R><K><F><S><P><I><G><G><T><G><P><S><S><D><A><G><W><G><C><M><L><R><C><G><Q><M><M><L><A><Q><A><L><I><C><R><H><L><G><R><D><W><S><W><E><K><Q><K><E><Q><P><K><E><Y><Q><R><I><L><Q><C><F><L><D><R><K><D><C><C><Y><S><I><H><Q><M><A><Q><M><G><V><G><E><G><K><S><I><G><E><W><F><G><P><N><T><V><A><Q><V><L><K><K><L><A><L><F><D><E><W><N><S><L><A><V><Y><V><S><M><D><N><T><V><V><I><E><D><I><K><K><M><C><R><V><L><P><L><S><A><D><T><A><G><D><R><P><P><D><S><L><T><A><S><N><Q><S><K><G><T><S><A><Y><C><S><A><W><K><P><L><L><L><I><V><P><L><R><L><G><I><N><Q><I><N><P><V><Y><V><D><A><F><K><E><C><F><K><M><P><Q><S><L><G><A><L><G><G><K><P><N><N><A><Y><Y><F><I><G><F><L><G><D><E><L><I><F><L><D><P><H><T><T><Q><T><F><V><D><T><E><E><N><G><T><V><N><D><Q><T><F><H><C><L><Q><S><P><Q><R><M><N><I><L><N><L><D><P><S><V><A><L><G><F><F><C><K><E><E><K><D><F><D><N><W><C><S><L><V><Q><K><E><I><L><K><E><N><L><R><M><F><E><L><V><Q><K><H><P><S><H><W><P><P><F><V><P><P><A><K><P><E><V><T><T><T><G><A><E><F><I><D><S><T><E><Q><L><E><E><F><D><L><E><E><D><F><E><I><L><S><V>
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins . The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine . Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy . Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP . Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 . In addition to the protease activity, also mediates delipidation of ATG8 family proteins . Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy . Compared to ATG4B, the major protein for proteolytic activation of
Q8WYN0
Q04118
PRB3_HUMAN
Proline-rich protein G1
Homo
<M><L><L><I><L><L><S><V><A><L><L><A><L><S><S><A><Q><S><L><N><E><D><V><S><Q><E><E><S><P><S><V><I><S><G><K><P><E><G><R><R><P><Q><G><G><N><Q><P><Q><R><T><P><P><P><P><G><K><P><E><G><R><P><P><Q><G><G><N><Q><S><Q><G><P><P><P><R><P><G><K><P><E><G><P><P><P><Q><G><G><N><Q><S><Q><G><P><P><P><R><P><G><K><P><E><G><Q><P><P><Q><G><G><N><Q><S><Q><G><P><P><P><R><P><G><K><P><E><G><P><P><P><Q><G><G><N><Q><S><Q><G><P><P><P><R><P><G><K><P><E><G><P><P><P><Q><G><G><N><Q><S><Q><G><P><P><P><H><P><G><K><P><E><G><P><P><P><Q><G><G><N><Q><S><Q><G><P><P><P><R><P><G><K><P><E><G><P><P><P><Q><G><G><N><Q><S><Q><G><P><P><P><R><P><G><K><P><E><G><P><P><P><Q><G><G><N><Q><S><Q><G><P><P><P><R><P><G><K><P><E><G><S><P><S><Q><G><G><N><K><P><Q><G><P><P><P><H><P><G><K><P><Q><G><P><P><P><Q><E><G><N><K><P><Q><R><P><P><P><P><G><R><P><Q><G><P><P><P><P><G><G><N><P><Q><Q><P><L><P><P><P><A><G><K><P><Q><G><P><P><P><P><P><Q><G><G><R><P><H><R><P><P><Q><G><Q><P><P><Q>
Acts as a receptor for the Gram-negative bacterium F.nucleatum.<BOP>
Q04118
Q32MQ0
ZN750_HUMAN
Zinc finger protein 750
Homo
<M><S><L><L><K><E><R><K><P><K><K><P><H><Y><I><P><R><P><P><G><K><P><F><K><Y><K><C><F><Q><C><P><F><T><C><N><E><K><S><H><L><F><N><H><M><K><Y><G><L><C><K><N><S><I><T><L><V><S><E><Q><D><R><V><P><K><C><P><K><S><N><S><L><D><P><K><Q><T><N><Q><P><D><A><T><A><K><P><A><S><S><K><S><V><A><N><G><L><S><A><F><D><S><K><L><Q><H><S><S><A><R><E><D><I><K><E><N><L><E><L><Q><A><R><G><T><H><R><C><L><G><Q><K><P><A><L><H><R><A><S><P><C><K><S><P><A><P><E><A><A><L><G><A><Q><P><A><L><E><G><A><A><R><P><S><A><F><V><P><V><G><E><H><R><L><K><G><P><D><N><A><E><A><P><E><T><L><A><L><H><N><P><T><A><K><A><V><S><F><H><T><K><S><A><F><H><T><P><G><Y><P><W><K><A><G><S><P><F><L><P><P><E><F><P><H><K><I><S><S><T><K><G><L><G><A><I><S><P><Y><M><H><P><T><I><P><E><Y><P><P><H><F><Y><T><E><H><G><L><A><T><I><Y><S><P><Y><L><L><A><G><S><S><P><E><C><D><A><P><L><L><S><V><Y><G><T><Q><D><P><R><H><F><L><P><H><P><G><P><I><P><K><H><L><A><P><S><P><A><T><Y><D><H><Y><R><F><F><Q><Q><Y><P><S><N><L><P><I><P><Y><G><F><Y><R><P><E><S><A><F><S><S><Y><G><L><R><L><P><P><V><T><G><L><T><R><D><Q><S><S><H><L><L><E><E><A><T><L><V><Y><P><A><S><S><P><S><R><L><N><P><S><D><P><N><R><K><H><V><E><F><E><S><P><I><P><E><A><K><D><S><S><K><A><G><Q><R><D><T><E><G><S><K><M><S><P><R><A><G><S><A><A><T><G><S><P><G><R><P><S><P><T><D><F><M><Q><T><S><Q><T><C><E><G><L><Y><D><L><S><N><K><A><A><S><S><A><L><G><R><L><Y><P><P><E><Q><S><L><T><A><F><R><P><V><K><K><S><T><E><C><L><P><A><Q><A><A><E><T><T><A><E><S><P><V><S><L><N><V><V><N><G><D><P><P><A><P><T><G><S><A><S><L><V><S><E><A><A><P><S><S><P><D><D><S><S><G><M><G><P><L><N><L><S><K><K><S><E><I><N><L><A><A><T><H><E><P><T><Y><Q><G><S><P><Q><A><E><T><A><S><F><S><E><L><Q><D><L><P><L><N><L><S><V><K><D><P><C><N><T><Q><A><P><R><P><A><F><P><G><R><P><R><A><A><E><P><A><A><A><V><P><Q><K><T><G><T><E><G><S><E><D><G><P><S><H><P><E><T><K><P><G><S><L><D><G><D><G><A><P><P><T><G><P><G><E><E><A><P><D><A><C><A><V><D><S><S><E><E><Q><K><Q><T><A><A><V><A><L><C><Q><L><A><A><Y><S><P><R><N><I><R><V><G><D><G><D><A><A><A><P><E><P><A><C><R><Q><D><T><P><T><L><S><S><M><E><S><Q><E><A><Q><C><D><L><R><P><K><G><Q><K><R><T><S><L><R><D><A><G><K><S><Q><Q><G><A><K><K><A><K><L><Q><D><T><A><R><V><F><T><L><R><R><R><A><R><V><S>
Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression.<BOP>
Q32MQ0
Q05084
ICA69_HUMAN
Islet cell autoantigen p69
Homo
<M><S><G><H><K><C><S><Y><P><W><D><L><Q><D><R><Y><A><Q><D><K><S><V><V><N><K><M><Q><Q><K><Y><W><E><T><K><Q><A><F><I><K><A><T><G><K><K><E><D><E><H><V><V><A><S><D><A><D><L><D><A><K><L><E><L><F><H><S><I><Q><R><T><C><L><D><L><S><K><A><I><V><L><Y><Q><K><R><I><C><F><L><S><Q><E><E><N><E><L><G><K><F><L><R><S><Q><G><F><Q><D><K><T><R><A><G><K><M><M><Q><A><T><G><K><A><L><C><F><S><S><Q><Q><R><L><A><L><R><N><P><L><C><R><F><H><Q><E><V><E><T><F><R><H><R><A><I><S><D><T><W><L><T><V><N><R><M><E><Q><C><R><T><E><Y><R><G><A><L><L><W><M><K><D><V><S><Q><E><L><D><P><D><L><Y><K><Q><M><E><K><F><R><K><V><Q><T><Q><V><R><L><A><K><K><N><F><D><K><L><K><M><D><V><C><Q><K><V><D><L><L><G><A><S><R><C><N><L><L><S><H><M><L><A><T><Y><Q><T><T><L><L><H><F><W><E><K><T><S><H><T><M><A><A><I><H><E><S><F><K><G><Y><Q><P><Y><E><F><T><T><L><K><S><L><Q><D><P><M><K><K><L><V><E><K><E><E><K><K><K><I><N><Q><Q><E><S><T><D><A><A><V><Q><E><P><S><Q><L><I><S><L><E><E><E><N><Q><R><K><E><S><S><S><F><K><T><E><D><G><K><S><I><L><S><A><L><D><K><G><S><T><H><T><A><C><S><G><P><I><D><E><L><L><D><M><K><S><E><E><G><A><C><L><G><P><V><A><G><T><P><E><P><E><G><A><D><K><D><D><L><L><L><L><S><E><I><F><N><A><S><S><L><E><E><G><E><F><S><K><E><W><A><A><V><F><G><D><G><Q><V><K><E><P><V><P><T><M><A><L><G><E><P><D><P><K><A><Q><T><G><S><G><F><L><P><S><Q><L><L><D><Q><N><M><K><D><L><Q><A><S><L><Q><E><P><A><K><A><A><S><D><L><T><A><W><F><S><L><F><A><D><L><D><P><L><S><N><P><D><A><V><G><K><T><D><K><E><H><E><L><L><N><A>
May play a role in neurotransmitter secretion.<BOP>
Q05084
P01270
PTHY_HUMAN
Parathyrin
Homo
<M><I><P><A><K><D><M><A><K><V><M><I><V><M><L><A><I><C><F><L><T><K><S><D><G><K><S><V><K><K><R><S><V><S><E><I><Q><L><M><H><N><L><G><K><H><L><N><S><M><E><R><V><E><W><L><R><K><K><L><Q><D><V><H><N><F><V><A><L><G><A><P><L><A><P><R><D><A><G><S><Q><R><P><R><K><K><E><D><N><V><L><V><E><S><H><E><K><S><L><G><E><A><D><K><A><D><V><N><V><L><T><K><A><K><S><Q>
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.<BOP>
P01270
P48307
TFPI2_HUMAN
Placental protein 5
Homo
<M><D><P><A><R><P><L><G><L><S><I><L><L><L><F><L><T><E><A><A><L><G><D><A><A><Q><E><P><T><G><N><N><A><E><I><C><L><L><P><L><D><Y><G><P><C><R><A><L><L><L><R><Y><Y><Y><D><R><Y><T><Q><S><C><R><Q><F><L><Y><G><G><C><E><G><N><A><N><N><F><Y><T><W><E><A><C><D><D><A><C><W><R><I><E><K><V><P><K><V><C><R><L><Q><V><S><V><D><D><Q><C><E><G><S><T><E><K><Y><F><F><N><L><S><S><M><T><C><E><K><F><F><S><G><G><C><H><R><N><R><I><E><N><R><F><P><D><E><A><T><C><M><G><F><C><A><P><K><K><I><P><S><F><C><Y><S><P><K><D><E><G><L><C><S><A><N><V><T><R><Y><Y><F><N><P><R><Y><R><T><C><D><A><F><T><Y><T><G><C><G><G><N><D><N><N><F><V><S><R><E><D><C><K><R><A><C><A><K><A><L><K><K><K><K><K><M><P><K><L><R><F><A><S><R><I><R><K><I><R><K><K><Q><F>
May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.<BOP>
P48307
Q5QGT7
RTP2_HUMAN
3CxxC-type zinc finger protein 2
Homo
<M><C><T><S><L><T><T><C><E><W><K><K><V><F><Y><E><K><M><E><V><A><K><P><A><D><S><W><E><L><I><I><D><P><N><L><K><P><S><E><L><A><P><G><W><K><Q><Y><L><E><Q><H><A><S><G><R><F><H><C><S><W><C><W><H><T><W><Q><S><A><H><V><V><I><L><F><H><M><F><L><D><R><A><Q><R><A><G><S><V><R><M><R><V><F><K><Q><L><C><Y><E><C><G><T><A><R><L><D><E><S><S><M><L><E><E><N><I><E><G><L><V><D><N><L><I><T><S><L><R><E><Q><C><Y><E><E><D><G><G><Q><Y><R><I><H><V><A><S><R><P><D><S><G><P><H><R><A><E><F><C><E><A><C><Q><E><G><I><V><H><W><K><P><S><E><K><L><L><E><E><E><V><T><T><Y><T><S><E><A><S><K><P><R><A><Q><A><G><S><G><Y><N><F><L><S><L><R><W><C><L><F><W><A><S><L><C><L><L><V><V><Y><L><Q><F><S><F><L><S><P><A><F><F>
Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.<BOP>
Q5QGT7
Q8N9W5
DAAF3_HUMAN
Dynein axonemal assembly factor 3
Homo
<M><T><T><P><A><G><S><G><S><G><F><G><S><V><S><W><W><G><L><S><P><A><L><D><L><Q><A><E><S><P><P><V><D><P><D><S><Q><A><D><T><V><H><S><N><P><E><L><D><V><L><L><L><G><S><V><D><G><R><H><L><L><R><T><L><S><R><A><K><F><W><P><R><R><R><F><N><F><F><V><L><E><N><N><L><E><A><V><A><R><H><M><L><I><F><S><L><A><L><E><E><P><E><K><M><G><L><Q><E><R><S><E><T><F><L><E><V><W><G><N><A><L><L><R><P><P><V><A><A><F><V><R><A><Q><A><D><L><L><A><H><L><V><P><E><P><D><R><L><E><E><Q><L><P><W><L><S><L><R><A><L><K><F><R><E><R><D><A><L><E><A><V><F><R><F><W><A><G><G><E><K><G><P><Q><A><F><P><M><S><R><L><W><D><S><R><L><R><H><Y><L><G><S><R><Y><D><A><R><R><G><V><S><D><W><D><L><R><M><K><L><H><D><R><G><A><Q><V><I><H><P><Q><E><F><R><R><W><R><D><T><G><V><A><F><E><L><R><D><S><S><A><Y><H><V><P><N><R><T><L><A><S><G><R><L><L><S><Y><R><G><E><R><V><A><A><R><G><Y><W><G><D><I><A><T><G><P><F><V><A><F><G><I><E><A><D><D><E><S><L><L><R><T><S><N><G><Q><P><V><K><T><A><G><E><I><T><Q><H><N><V><T><E><L><L><R><D><V><A><A><W><G><R><A><R><A><T><G><G><D><L><E><E><Q><Q><H><A><E><G><S><P><E><P><G><T><P><A><A><P><T><P><E><S><F><T><V><H><F><L><P><L><N><S><A><Q><T><L><H><H><K><S><C><Y><N><G><R><F><Q><L><L><Y><V><A><C><G><M><V><H><L><L><I><P><E><L><G><A><C><V><A><P><G><G><N><L><I><V><E><L><A><R><Y><L><V><D><V><R><Q><E><Q><L><Q><G><F><N><T><R><V><R><E><L><A><Q><A><A><G><F><A><P><Q><T><G><A><R><P><S><E><T><F><A><R><F><C><K><S><Q><E><S><A><L><G><N><T><V><P><A><V><E><P><G><T><P><P><L><D><I><L><A><Q><P><L><E><A><S><N><P><A><L><E><G><L><T><Q><P><L><Q><G><G><T><P><H><C><E><P><C><Q><L><P><S><E><S><P><G><S><L><S><E><V><L><A><Q><P><Q><G><A><L><A><P><P><N><C><E><S><D><S><K><T><G><V>
Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.<BOP>
Q8N9W5
Q9Y575
ASB3_HUMAN
Ankyrin repeat and SOCS box protein 3
Homo
<M><D><F><T><E><A><Y><A><D><T><C><S><T><V><G><L><A><A><R><E><G><N><V><K><V><L><R><K><L><L><K><K><G><R><S><V><D><V><A><D><N><R><G><W><M><P><I><H><E><A><A><Y><H><N><S><V><E><C><L><Q><M><L><I><N><A><D><S><S><E><N><Y><I><K><M><K><T><F><E><G><F><C><A><L><H><L><A><A><S><Q><G><H><W><K><I><V><Q><I><L><L><E><A><G><A><D><P><N><A><T><T><L><E><E><T><T><P><L><F><L><A><V><E><N><G><Q><I><D><V><L><R><L><L><L><Q><H><G><A><N><V><N><G><S><H><S><M><C><G><W><N><S><L><H><Q><A><S><F><Q><E><N><A><E><I><I><K><L><L><L><R><K><G><A><N><K><E><C><Q><D><D><F><G><I><T><P><L><F><V><A><A><Q><Y><G><K><L><E><S><L><S><I><L><I><S><S><G><A><N><V><N><C><Q><A><L><D><K><A><T><P><L><F><I><A><A><Q><E><G><H><T><K><C><V><E><L><L><L><S><S><G><A><D><P><D><L><Y><C><N><E><D><S><W><Q><L><P><I><H><A><A><A><Q><M><G><H><T><K><I><L><D><L><L><I><P><L><T><N><R><A><C><D><T><G><L><N><K><V><S><P><V><Y><S><A><V><F><G><G><H><E><D><C><L><E><I><L><L><R><N><G><Y><S><P><D><A><Q><A><C><L><V><F><G><F><S><S><P><V><C><M><A><F><Q><K><D><C><E><F><F><G><I><V><N><I><L><L><K><Y><G><A><Q><I><N><E><L><H><L><A><Y><C><L><K><Y><E><K><F><S><I><F><R><Y><F><L><R><K><G><C><S><L><G><P><W><N><H><I><Y><E><F><V><N><H><A><I><K><A><Q><A><K><Y><K><E><W><L><P><H><L><L><V><A><G><F><D><P><L><I><L><L><C><N><S><W><I><D><S><V><S><I><D><T><L><I><F><T><L><E><F><T><N><W><K><T><L><A><P><A><V><E><R><M><L><S><A><R><A><S><N><A><W><I><L><Q><Q><H><I><A><T><V><P><S><L><T><H><L><C><R><L><E><I><R><S><S><L><K><S><E><R><L><R><S><D><S><Y><I><S><Q><L><P><L><P><R><S><L><H><N><Y><L><L><Y><E><D><V><L><R><M><Y><E><V><P><E><L><A><A><I><Q><D><G>
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.<BOP>
Q9Y575
Q15554
TERF2_HUMAN
Telomeric DNA-binding protein
Homo
<M><A><A><G><A><G><T><A><G><P><A><S><G><P><G><V><V><R><D><P><A><A><S><Q><P><R><K><R><P><G><R><E><G><G><E><G><A><R><R><S><D><T><M><A><G><G><G><G><S><S><D><G><S><G><R><A><A><G><R><R><A><S><R><S><S><G><R><A><R><R><G><R><H><E><P><G><L><G><G><P><A><E><R><G><A><G><E><A><R><L><E><E><A><V><N><R><W><V><L><K><F><Y><F><H><E><A><L><R><A><F><R><G><S><R><Y><G><D><F><R><Q><I><R><D><I><M><Q><A><L><L><V><R><P><L><G><K><E><H><T><V><S><R><L><L><R><V><M><Q><C><L><S><R><I><E><E><G><E><N><L><D><C><S><F><D><M><E><A><E><L><T><P><L><E><S><A><I><N><V><L><E><M><I><K><T><E><F><T><L><T><E><A><V><V><E><S><S><R><K><L><V><K><E><A><A><V><I><I><C><I><K><N><K><E><F><E><K><A><S><K><I><L><K><K><H><M><S><K><D><P><T><T><Q><K><L><R><N><D><L><L><N><I><I><R><E><K><N><L><A><H><P><V><I><Q><N><F><S><Y><E><T><F><Q><Q><K><M><L><R><F><L><E><S><H><L><D><D><A><E><P><Y><L><L><T><M><A><K><K><A><L><K><S><E><S><A><A><S><S><T><G><K><E><D><K><Q><P><A><P><G><P><V><E><K><P><P><R><E><P><A><R><Q><L><R><N><P><P><T><T><I><G><M><M><T><L><K><A><A><F><K><T><L><S><G><A><Q><D><S><E><A><A><F><A><K><L><D><Q><K><D><L><V><L><P><T><Q><A><L><P><A><S><P><A><L><K><N><K><R><P><R><K><D><E><N><E><S><S><A><P><A><D><G><E><G><G><S><E><L><Q><P><K><N><K><R><M><T><I><S><R><L><V><L><E><E><D><S><Q><S><T><E><P><S><A><G><L><N><S><S><Q><E><A><A><S><A><P><P><S><K><P><T><V><L><N><Q><P><L><P><G><E><K><N><P><K><V><P><K><G><K><W><N><S><S><N><G><V><E><E><K><E><T><W><V><E><E><D><E><L><F><Q><V><Q><A><A><P><D><E><D><S><T><T><N><I><T><K><K><Q><K><W><T><V><E><E><S><E><W><V><K><A><G><V><Q><K><Y><G><E><G><N><W><A><A><I><S><K><N><Y><P><F><V><N><R><T><A><V><M><I><K><D><R><W><R><T><M><K><R><L><G><M><N>
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/A
Q15554
P08246
ELNE_HUMAN
PMN elastase
Homo
<M><T><L><G><R><R><L><A><C><L><F><L><A><C><V><L><P><A><L><L><L><G><G><T><A><L><A><S><E><I><V><G><G><R><R><A><R><P><H><A><W><P><F><M><V><S><L><Q><L><R><G><G><H><F><C><G><A><T><L><I><A><P><N><F><V><M><S><A><A><H><C><V><A><N><V><N><V><R><A><V><R><V><V><L><G><A><H><N><L><S><R><R><E><P><T><R><Q><V><F><A><V><Q><R><I><F><E><N><G><Y><D><P><V><N><L><L><N><D><I><V><I><L><Q><L><N><G><S><A><T><I><N><A><N><V><Q><V><A><Q><L><P><A><Q><G><R><R><L><G><N><G><V><Q><C><L><A><M><G><W><G><L><L><G><R><N><R><G><I><A><S><V><L><Q><E><L><N><V><T><V><V><T><S><L><C><R><R><S><N><V><C><T><L><V><R><G><R><Q><A><G><V><C><F><G><D><S><G><S><P><L><V><C><N><G><L><I><H><G><I><A><S><F><V><R><G><G><C><A><S><G><L><Y><P><D><A><F><A><P><V><A><Q><F><V><N><W><I><D><S><I><I><Q><R><S><E><D><N><P><C><P><H><P><R><D><P><D><P><A><S><R><T><H>
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis . Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae .<BOP>
P08246
Q5T9C2
F102A_HUMAN
Early estrogen-induced gene 1 protein
Homo
<M><A><F><L><M><K><K><K><K><F><K><F><Q><T><T><F><T><L><E><E><L><T><A><V><P><F><V><N><G><V><L><F><C><K><V><R><L><L><D><G><G><D><F><V><S><L><S><S><R><E><E><V><Q><E><N><C><V><R><W><R><K><R><F><T><F><V><C><K><M><S><A><N><P><A><T><G><L><L><D><P><C><V><F><R><V><S><V><R><K><E><L><K><G><G><K><A><Y><S><K><L><G><F><A><D><L><N><L><A><E><F><A><G><S><G><S><T><V><R><C><C><L><L><E><G><Y><D><T><K><N><T><R><Q><D><N><S><I><L><K><V><T><I><G><M><F><L><L><S><G><D><P><C><F><K><T><P><P><S><T><A><K><S><I><S><I><P><G><Q><D><S><S><L><Q><L><T><C><K><G><G><G><T><S><S><G><G><S><S><T><N><S><L><T><G><S><R><P><P><K><A><R><P><T><I><L><S><S><G><L><P><E><E><P><D><Q><N><L><S><S><P><E><E><V><F><H><S><G><H><S><R><N><S><S><Y><A><S><Q><Q><S><K><I><S><G><Y><S><T><E><H><S><R><S><S><S><L><S><D><L><T><H><R><R><N><T><S><T><S><S><S><A><S><G><G><L><G><M><T><V><E><G><P><E><G><S><E><R><E><H><R><P><P><E><K><P><P><R><P><P><R><P><L><H><L><S><D><R><S><F><R><R><K><K><D><S><V><E><S><H><P><T><W><V><D><D><T><R><I><D><A><D><A><I><V><E><K><I><V><Q><S><Q><D><F><T><D><G><S><N><T><E><D><S><N><L><R><L><F><V><S><R><D><G><S><A><T><L><S><G><I><Q><L><A><T><R><V><S><S><G><V><Y><E><P><V><V><I><E><S><H>
May play a role in estrogen action.<BOP>
Q5T9C2
B2RN74
O11HC_HUMAN
Olfactory receptor 11H12
Homo
<M><C><P><L><T><L><Q><V><T><G><L><M><N><V><S><E><P><N><S><S><F><A><F><V><N><E><F><I><L><Q><G><F><T><C><E><W><T><I><Q><I><F><L><F><S><L><F><T><T><T><Y><A><L><T><I><T><G><N><G><A><I><A><F><V><L><W><C><D><W><R><L><H><T><P><M><Y><M><F><L><G><N><F><S><F><L><E><I><W><Y><V><S><S><T><V><P><K><M><L><V><N><F><L><S><E><K><K><N><I><S><F><A><G><C><F><L><Q><F><Y><F><F><F><S><L><G><T><S><E><C><L><L><L><T><V><M><A><F><D><Q><Y><L><A><I><C><R><P><L><L><Y><P><N><I><M><T><G><H><L><C><A><K><L><V><I><L><C><W><V><C><G><F><L><W><F><L><I><P><I><V><L><I><S><Q><M><P><F><C><G><P><N><I><I><D><H><V><V><C><D><P><G><P><R><F><A><L><D><C><V><S><A><P><R><I><Q><L><F><C><Y><T><L><S><S><L><V><I><F><G><N><F><L><F><I><I><G><S><Y><T><L><V><L><K><A><V><L><G><M><P><S><S><T><G><R><H><K><A><F><S><T><C><G><S><H><L><A><V><V><S><L><C><Y><S><S><L><M><V><M><Y><V><S><P><G><L><G><H><S><T><G><M><Q><K><I><E><T><L><F><Y><A><M><V><T><P><L><F><N><P><L><I><Y><S><L><Q><N><K><E><I><K><A><A><L><R><K><V><L><G><S><S><N><I><I>
Odorant receptor.<BOP>
B2RN74
Q92733
PRCC_HUMAN
Papillary renal cell carcinoma translocation-associated gene protein
Homo
<M><S><L><V><A><Y><A><S><S><D><E><S><E><P><D><E><A><E><P><E><P><E><E><E><E><A><V><A><P><T><S><G><P><A><L><G><G><L><F><A><S><L><P><A><P><K><G><P><A><L><L><P><P><P><P><Q><M><L><A><P><A><F><P><P><P><L><L><L><P><P><P><T><G><D><P><R><L><Q><P><P><P><P><L><P><F><G><L><G><G><F><P><P><P><P><G><V><S><P><A><E><A><A><G><V><G><E><G><L><G><L><G><L><P><S><P><R><G><P><G><L><N><L><P><P><P><I><G><G><A><G><P><P><L><G><L><P><K><P><K><K><R><K><E><P><V><K><I><A><A><P><E><L><H><K><G><D><S><D><S><E><E><D><E><P><T><K><K><K><T><I><L><Q><G><S><S><E><G><T><G><L><S><A><L><L><P><Q><P><K><N><L><T><V><K><E><T><N><R><L><L><L><P><H><A><F><S><R><K><P><S><D><G><S><P><D><T><K><P><S><R><L><A><S><K><T><K><T><S><S><L><A><P><V><V><G><T><T><T><T><T><P><S><P><S><A><I><K><A><A><A><K><S><A><A><L><Q><V><T><K><Q><I><T><Q><E><E><D><D><S><D><E><E><V><A><P><E><N><F><F><S><L><P><E><K><A><E><P><P><G><V><E><P><Y><P><Y><P><I><P><T><V><P><E><E><L><P><P><G><T><E><P><E><P><A><F><Q><D><D><A><A><N><A><P><L><E><F><K><M><A><A><G><S><S><G><A><P><W><M><P><K><P><G><D><D><Y><S><Y><N><Q><F><S><T><Y><G><D><A><N><A><A><G><A><Y><Y><Q><D><Y><Y><S><G><G><Y><Y><P><A><Q><D><P><A><L><V><P><P><Q><E><I><A><P><D><A><S><F><I><D><D><E><A><F><K><R><L><Q><G><K><R><N><R><G><R><E><E><I><N><F><V><E><I><K><G><D><D><Q><L><S><G><A><Q><Q><W><M><T><K><S><L><T><E><E><K><T><M><K><S><F><S><K><K><K><G><E><Q><P><T><G><Q><Q><R><R><K><H><Q><I><T><Y><L><I><H><Q><A><K><E><R><E><L><E><L><K><N><T><W><S><E><N><K><L><S><R><R><Q><T><Q><A><K><Y><G><F>
May regulate cell cycle progression through interaction with MAD2L2.<BOP>
Q92733
Q8N6H7
ARFG2_HUMAN
Zinc finger protein 289
Homo
<M><A><A><E><P><N><K><T><E><I><Q><T><L><F><K><R><L><R><A><V><P><T><N><K><A><C><F><D><C><G><A><K><N><P><S><W><A><S><I><T><Y><G><V><F><L><C><I><D><C><S><G><V><H><R><S><L><G><V><H><L><S><F><I><R><S><T><E><L><D><S><N><W><N><W><F><Q><L><R><C><M><Q><V><G><G><N><A><N><A><T><A><F><F><R><Q><H><G><C><T><A><N><D><A><N><T><K><Y><N><S><R><A><A><Q><M><Y><R><E><K><I><R><Q><L><G><S><A><A><L><A><R><H><G><T><D><L><W><I><D><N><M><S><S><A><V><P><N><H><S><P><E><K><K><D><S><D><F><F><T><E><H><T><Q><P><P><A><W><D><A><P><A><T><E><P><S><G><T><Q><Q><P><A><P><S><T><E><S><S><G><L><A><Q><P><E><H><G><P><N><T><D><L><L><G><T><S><P><K><A><S><L><E><L><K><S><S><I><I><G><K><K><K><P><A><A><A><K><K><G><L><G><A><K><K><G><L><G><A><Q><K><V><S><S><Q><S><F><S><E><I><E><R><Q><A><Q><V><A><E><K><L><R><E><Q><Q><A><A><D><A><K><K><Q><A><E><E><S><M><V><A><S><M><R><L><A><Y><Q><E><L><Q><I><D><R><K><K><E><E><K><K><L><Q><N><L><E><G><K><K><R><E><Q><A><E><R><L><G><M><G><L><V><S><R><S><S><V><S><H><S><V><L><S><E><M><Q><V><I><E><Q><E><T><P><V><S><A><K><S><S><R><S><Q><L><D><L><F><D><D><V><G><T><F><A><S><G><P><P><K><Y><K><D><N><P><F><S><L><G><E><S><F><G><S><R><W><D><T><D><A><A><W><G><M><D><R><V><E><E><K><E><P><E><V><T><I><S><S><I><R><P><I><S><E><R><A><T><N><R><R><E><V><E><S><R><S><S><G><L><E><S><S><E><A><R><Q><K><F><A><G><A><K><A><I><S><S><D><M><F><F><G><R><E><V><D><A><E><Y><E><A><R><S><R><L><Q><Q><L><S><G><S><S><A><I><S><S><S><D><L><F><G><D><M><D><G><A><H><G><A><G><S><V><S><L><G><N><V><L><P><T><A><D><I><A><Q><F><K><Q><G><V><K><S><V><A><G><K><M><A><V><L><A><N><G><V><M><N><S><L><Q><D><R><Y><G><S><Y>
GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.<BOP>
Q8N6H7
A0A1B0GX78
TVBL5_HUMAN
T cell receptor beta variable 12-5
Homo
<M><A><T><R><L><L><C><C><V><V><L><C><L><L><G><E><E><L><I><D><A><R><V><T><Q><T><P><R><H><K><V><T><E><M><G><Q><E><V><T><M><R><C><Q><P><I><L><G><H><N><T><V><F><W><Y><R><Q><T><M><M><Q><G><L><E><L><L><A><Y><F><R><N><R><A><P><L><D><D><S><G><M><P><K><D><R><F><S><A><E><M><P><D><A><T><L><A><T><L><K><I><Q><P><S><E><P><R><D><S><A><V><Y><F><C><A><S><G><L>
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A1B0GX78
P21291
CSRP1_HUMAN
Epididymis luminal protein 141
Homo
<M><P><N><W><G><G><G><K><K><C><G><V><C><Q><K><T><V><Y><F><A><E><E><V><Q><C><E><G><N><S><F><H><K><S><C><F><L><C><M><V><C><K><K><N><L><D><S><T><T><V><A><V><H><G><E><E><I><Y><C><K><S><C><Y><G><K><K><Y><G><P><K><G><Y><G><Y><G><Q><G><A><G><T><L><S><T><D><K><G><E><S><L><G><I><K><H><E><E><A><P><G><H><R><P><T><T><N><P><N><A><S><K><F><A><Q><K><I><G><G><S><E><R><C><P><R><C><S><Q><A><V><Y><A><A><E><K><V><I><G><A><G><K><S><W><H><K><A><C><F><R><C><A><K><C><G><K><G><L><E><S><T><T><L><A><D><K><D><G><E><I><Y><C><K><G><C><Y><A><K><N><F><G><P><K><G><F><G><F><G><Q><G><A><G><A><L><V><H><S><E>
Could play a role in neuronal development.<BOP>
P21291
O60760
HPGDS_HUMAN
Prostaglandin-H2 D-isomerase
Homo
<M><P><N><Y><K><L><T><Y><F><N><M><R><G><R><A><E><I><I><R><Y><I><F><A><Y><L><D><I><Q><Y><E><D><H><R><I><E><Q><A><D><W><P><E><I><K><S><T><L><P><F><G><K><I><P><I><L><E><V><D><G><L><T><L><H><Q><S><L><A><I><A><R><Y><L><T><K><N><T><D><L><A><G><N><T><E><M><E><Q><C><H><V><D><A><I><V><D><T><L><D><D><F><M><S><C><F><P><W><A><E><K><K><Q><D><V><K><E><Q><M><F><N><E><L><L><T><Y><N><A><P><H><L><M><Q><D><L><D><T><Y><L><G><G><R><E><W><L><I><G><N><S><V><T><W><A><D><F><Y><W><E><I><C><S><T><T><L><L><V><F><K><P><D><L><L><D><N><H><P><R><L><V><T><L><R><K><K><V><Q><A><I><P><A><V><A><N><W><I><K><R><R><P><Q><T><K><L>
Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<BOP>
O60760
Q96E39
RMXL1_HUMAN
Heterogeneous nuclear ribonucleoprotein G-like 1
Homo
<M><V><E><A><D><R><P><G><K><L><F><I><G><G><L><N><T><E><T><N><E><K><A><L><E><T><V><F><G><K><Y><G><R><I><V><E><V><L><L><I><K><D><R><E><T><N><K><S><R><G><F><A><F><V><T><F><E><S><P><A><D><A><K><D><A><A><R><D><M><N><G><K><S><L><D><G><K><A><I><K><V><E><Q><A><T><K><P><S><F><E><R><G><R><H><G><P><P><P><P><P><R><S><R><G><P><P><R><G><F><G><A><G><R><G><G><S><G><G><T><R><G><P><P><S><R><G><G><H><M><D><D><G><G><Y><S><M><N><F><N><M><S><S><S><R><G><P><L><P><V><K><R><G><P><P><P><R><S><G><G><P><S><P><K><R><S><A><P><S><G><L><V><R><S><S><S><G><M><G><G><R><A><P><L><S><R><G><R><D><S><Y><G><G><P><P><R><R><E><P><L><P><S><R><R><D><V><Y><L><S><P><R><D><D><G><Y><S><T><K><D><S><Y><S><S><R><D><Y><P><S><S><R><D><T><R><D><Y><A><P><P><P><R><D><Y><T><Y><R><D><Y><G><H><S><S><S><R><D><D><Y><P><S><R><G><Y><G><D><R><D><G><Y><G><R><D><R><D><Y><S><D><H><P><S><G><G><S><Y><R><D><S><Y><E><S><Y><G><N><S><R><S><A><P><L><T><R><G><P><P><P><S><Y><G><G><S><S><R><Y><D><D><Y><S><S><S><R><D><G><Y><G><G><S><R><D><S><Y><S><S><S><R><S><D><L><Y><S><S><C><D><R><V><G><R><Q><E><R><G><L><P><P><S><V><E><R><G><Y><P><S><S><R><D><S><Y><S><S><S><S><R><G><A><P><R><G><A><G><P><G><G><S><R><S><D><R><G><G><G><R><S><R><Y>
RNA-binding protein which may be involved in pre-mRNA splicing.<BOP>
Q96E39
Q68DK7
MSL1_HUMAN
Male-specific lethal-1 homolog 1
Homo
<M><T><M><R><S><A><V><F><K><A><A><A><A><P><A><G><G><N><P><E><Q><R><L><D><Y><E><R><A><A><A><L><G><G><P><E><D><E><P><G><A><A><E><A><H><F><L><P><R><H><R><K><L><K><E><P><G><P><P><L><A><S><S><Q><G><G><S><P><A><P><S><P><A><G><C><G><G><K><G><R><G><L><L><L><P><A><G><A><A><P><G><Q><Q><E><E><S><W><G><G><S><V><P><L><P><C><P><P><P><A><T><K><Q><A><G><I><G><G><E><P><A><A><A><G><A><G><C><S><P><R><P><K><Y><Q><A><V><L><P><I><Q><T><G><S><L><V><A><A><A><K><E><P><T><P><W><A><G><D><K><G><G><A><A><S><P><A><A><T><A><S><D><P><A><G><P><P><P><L><P><L><P><G><P><P><P><L><A><P><T><A><T><A><G><T><L><A><A><S><E><G><R><W><K><S><M><R><K><S><P><L><G><G><G><G><G><S><G><A><S><S><Q><A><A><C><L><K><Q><I><L><L><L><Q><L><D><L><I><E><Q><Q><Q><Q><Q><L><Q><A><K><E><K><E><I><E><E><L><K><S><E><R><D><T><L><L><A><R><I><E><R><M><E><R><R><M><Q><L><V><K><K><D><N><E><K><E><R><H><K><L><F><Q><G><Y><E><T><E><E><R><E><E><T><E><L><S><E><K><I><K><L><E><C><Q><P><E><L><S><E><T><S><Q><T><L><P><P><K><P><F><S><C><G><R><S><G><K><G><H><K><R><K><S><P><F><G><S><T><E><R><K><T><P><V><K><K><L><A><P><E><F><S><K><V><K><T><K><T><P><K><H><S><P><I><K><E><E><P><C><G><S><L><S><E><T><V><C><K><R><E><L><R><S><Q><E><T><P><E><K><P><R><S><S><V><D><T><P><P><R><L><S><T><P><Q><K><G><P><S><T><H><P><K><E><K><A><F><S><S><E><I><E><D><L><P><Y><L><S><T><T><E><M><Y><L><C><R><W><H><Q><P><P><P><S><P><L><P><L><R><E><S><S><P><K><K><E><E><T><V><A><R><C><L><M><P><S><S><V><A><G><E><T><S><V><L><A><V><P><S><W><R><D><H><S><V><E><P><L><R><D><P><N><P><S><D><L><L><E><N><L><D><D><S><V><F><S><K><R><H><A><K><L><E><L><D><E><K><R><R><K><R><W><D><I><Q><R><I><R><E><Q><R><I><L><Q><R><L><Q><L><R><M><Y><K><K><K><G><I><Q><E><S><E><P><E><V><T><S><F><F><P><E><P><D><D><V><E><S><L><M><I><T><P><F><L><P><V><V><A><F><G><R><P><L><P><K><L><T><P><Q><N><F><E><L><P><W><L><D><E><R><S><R><C><R><L><E><I><Q><K><K><Q><T><P><H><R><T><C><R><K>
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure . Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) . This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 . In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation .<BOP>
Q68DK7
A6NF83
NUPR2_HUMAN
Nuclear transcriptional regulator protein 2
Homo
<M><E><A><P><A><E><R><A><L><P><R><L><Q><A><L><A><R><P><P><P><P><I><S><Y><E><E><E><L><Y><D><C><L><D><Y><Y><Y><L><R><D><F><P><A><C><G><A><G><R><S><K><G><R><T><R><R><E><Q><A><L><R><T><N><W><P><A><P><G><G><H><E><R><K><V><A><Q><K><L><L><N><G><Q><R><K><R><R><Q><R><Q><L><H><P><K><M><R><T><R><L><T>
Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells . Involved in the G1 cell cycle arrest, and in a decrease in cell viability and cell proliferation . Plays a role as a negative regulator of the protumoral factor NUPR1 .<BOP>
A6NF83
Q11130
FUT7_HUMAN
Selectin ligand synthase
Homo
<M><N><N><A><G><H><G><P><T><R><R><L><R><G><L><G><V><L><A><G><V><A><L><L><A><A><L><W><L><L><W><L><L><G><S><A><P><R><G><T><P><A><P><Q><P><T><I><T><I><L><V><W><H><W><P><F><T><D><Q><P><P><E><L><P><S><D><T><C><T><R><Y><G><I><A><R><C><H><L><S><A><N><R><S><L><L><A><S><A><D><A><V><V><F><H><H><R><E><L><Q><T><R><R><S><H><L><P><L><A><Q><R><P><R><G><Q><P><W><V><W><A><S><M><E><S><P><S><H><T><H><G><L><S><H><L><R><G><I><F><N><W><V><L><S><Y><R><R><D><S><D><I><F><V><P><Y><G><R><L><E><P><H><W><G><P><S><P><P><L><P><A><K><S><R><V><A><A><W><V><V><S><N><F><Q><E><R><Q><L><R><A><R><L><Y><R><Q><L><A><P><H><L><R><V><D><V><F><G><R><A><N><G><R><P><L><C><A><S><C><L><V><P><T><V><A><Q><Y><R><F><Y><L><S><F><E><N><S><Q><H><R><D><Y><I><T><E><K><F><W><R><N><A><L><V><A><G><T><V><P><V><V><L><G><P><P><R><A><T><Y><E><A><F><V><P><A><D><A><F><V><H><V><D><D><F><G><S><A><R><E><L><A><A><F><L><T><G><M><N><E><S><R><Y><Q><R><F><F><A><W><R><D><R><L><R><V><R><L><F><T><D><W><R><E><R><F><C><A><I><C><D><R><Y><P><H><L><P><R><S><Q><V><Y><E><D><L><E><G><W><F><Q><A>
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein or a glycolipid-linked sialopolylactosamines chain through an alpha-1,3 glycosidic linkage and participates in the final fucosylation step in the biosynthesis of the sialyl Lewis X (sLe(x)), a carbohydrate involved in cell and matrix adhesion during leukocyte trafficking and fertilization . In vitro, also synthesizes sialyl-dimeric-Lex structures, from VIM-2 structures and both di-fucosylated and trifucosylated structures from mono-fucosylated precursors . However does not catalyze alpha 1-3 fucosylation when an internal alpha 1-3 fucosylation is present in polylactosamine chain and the fucosylation rate of the internal GlcNAc residues is reduced once fucose has been added to the distal GlcNAc . Also catalyzes the transfer of a fucose from GDP
Q11130
Q8NGS8
O13C5_HUMAN
Olfactory receptor OR9-11
Homo
<M><E><W><E><N><H><T><I><L><V><E><F><F><L><K><G><L><S><G><H><P><R><L><E><L><L><F><F><V><L><I><F><I><M><Y><V><V><I><L><L><G><N><G><T><L><I><L><I><S><I><L><D><P><H><L><H><T><P><M><Y><F><F><L><G><N><L><S><F><L><D><I><C><Y><T><T><T><S><I><P><S><T><L><V><S><F><L><S><E><R><K><T><I><S><L><S><G><C><A><V><Q><M><F><L><S><L><A><M><G><T><T><E><C><V><L><L><G><V><M><A><F><D><R><Y><V><A><I><C><N><P><L><R><Y><P><I><I><M><S><K><D><A><Y><V><P><M><A><A><G><S><W><I><I><G><A><V><N><S><A><V><Q><T><V><F><V><V><Q><L><P><F><C><R><N><N><I><I><N><H><F><T><C><E><I><L><A><V><M><K><L><A><C><A><D><I><S><G><N><E><F><I><L><L><V><T><T><T><L><F><L><L><T><P><L><L><L><I><I><V><S><Y><T><L><I><I><L><S><I><F><K><I><S><S><S><E><G><R><S><K><P><S><S><T><C><S><A><R><L><T><V><V><I><T><F><C><G><T><I><F><L><M><Y><M><K><P><K><S><Q><E><T><L><N><S><D><D><L><D><A><T><D><K><L><I><F><I><F><Y><R><V><M><T><P><M><M><N><P><L><I><Y><S><L><R><N><K><D><V><K><E><A><V><K><H><L><L><R><R><K><N><F><N><K>
Odorant receptor.<BOP>
Q8NGS8
Q13115
DUS4_HUMAN
Mitogen-activated protein kinase phosphatase 2
Homo
<M><V><T><M><E><E><L><R><E><M><D><C><S><V><L><K><R><L><M><N><R><D><E><N><G><G><G><A><G><G><S><G><S><H><G><T><L><G><L><P><S><G><G><K><C><L><L><L><D><C><R><P><F><L><A><H><S><A><G><Y><I><L><G><S><V><N><V><R><C><N><T><I><V><R><R><R><A><K><G><S><V><S><L><E><Q><I><L><P><A><E><E><E><V><R><A><R><L><R><S><G><L><Y><S><A><V><I><V><Y><D><E><R><S><P><R><A><E><S><L><R><E><D><S><T><V><S><L><V><V><Q><A><L><R><R><N><A><E><R><T><D><I><C><L><L><K><G><G><Y><E><R><F><S><S><E><Y><P><E><F><C><S><K><T><K><A><L><A><A><I><P><P><P><V><P><P><S><A><T><E><P><L><D><L><G><C><S><S><C><G><T><P><L><H><D><Q><G><G><P><V><E><I><L><P><F><L><Y><L><G><S><A><Y><H><A><A><R><R><D><M><L><D><A><L><G><I><T><A><L><L><N><V><S><S><D><C><P><N><H><F><E><G><H><Y><Q><Y><K><C><I><P><V><E><D><N><H><K><A><D><I><S><S><W><F><M><E><A><I><E><Y><I><D><A><V><K><D><C><R><G><R><V><L><V><H><C><Q><A><G><I><S><R><S><A><T><I><C><L><A><Y><L><M><M><K><K><R><V><R><L><E><E><A><F><E><F><V><K><Q><R><R><S><I><I><S><P><N><F><S><F><M><G><Q><L><L><Q><F><E><S><Q><V><L><A><T><S><C><A><A><E><A><A><S><P><S><G><P><L><R><E><R><G><K><T><P><A><T><P><T><S><Q><F><V><F><S><F><P><V><S><V><G><V><H><S><A><P><S><S><L><P><Y><L><H><S><P><I><T><T><S><P><S><C>
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.<BOP>
Q13115
P10747
CD28_HUMAN
TP44
Homo
<M><L><R><L><L><L><A><L><N><L><F><P><S><I><Q><V><T><G><N><K><I><L><V><K><Q><S><P><M><L><V><A><Y><D><N><A><V><N><L><S><C><K><Y><S><Y><N><L><F><S><R><E><F><R><A><S><L><H><K><G><L><D><S><A><V><E><V><C><V><V><Y><G><N><Y><S><Q><Q><L><Q><V><Y><S><K><T><G><F><N><C><D><G><K><L><G><N><E><S><V><T><F><Y><L><Q><N><L><Y><V><N><Q><T><D><I><Y><F><C><K><I><E><V><M><Y><P><P><P><Y><L><D><N><E><K><S><N><G><T><I><I><H><V><K><G><K><H><L><C><P><S><P><L><F><P><G><P><S><K><P><F><W><V><L><V><V><V><G><G><V><L><A><C><Y><S><L><L><V><T><V><A><F><I><I><F><W><V><R><S><K><R><S><R><L><L><H><S><D><Y><M><N><M><T><P><R><R><P><G><P><T><R><K><H><Y><Q><P><Y><A><P><P><R><D><F><A><A><Y><R><S>
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation . Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells .<BOP>
P10747
Q9H2X8
I27L2_HUMAN
pIFI27-like protein
Homo
<M><M><K><R><A><A><A><A><A><V><G><G><A><L><A><V><G><A><V><P><V><V><L><S><A><M><G><F><T><G><A><G><I><A><A><S><S><I><A><A><K><M><M><S><A><A><A><I><A><N><G><G><G><V><S><A><G><S><L><V><A><T><L><Q><S><V><G><A><A><G><L><S><T><S><S><N><I><L><L><A><S><V><G><S><V><L><G><A><C><L><G><N><S><P><S><S><S><L><P><A><E><P><E><A><K><E><D><E><A><R><E><N><V><P><Q><G><E><P><P><K><P><P><L><K><S><E><K><H><E><E>
Plays a role in the apoptotic process and has a pro-apoptotic activity.<BOP>
Q9H2X8
Q02086
SP2_HUMAN
Transcription factor Sp2
Homo
<M><S><D><P><Q><T><S><M><A><A><T><A><A><V><S><P><S><D><Y><L><Q><P><A><A><S><T><T><Q><D><S><Q><P><S><P><L><A><L><L><A><A><T><C><S><K><I><G><P><P><A><V><E><A><A><V><T><P><P><A><P><P><Q><P><T><P><R><K><L><V><P><I><K><P><A><P><L><P><L><S><P><G><K><N><S><F><G><I><L><S><S><K><G><N><I><L><Q><I><Q><G><S><Q><L><S><A><S><Y><P><G><G><Q><L><V><F><A><I><Q><N><P><T><M><I><N><K><G><T><R><S><N><A><N><I><Q><Y><Q><A><V><P><Q><I><Q><A><S><N><S><Q><T><I><Q><V><Q><P><N><L><T><N><Q><I><Q><I><I><P><G><T><N><Q><A><I><I><T><P><S><P><S><S><H><K><P><V><P><I><K><P><A><P><I><Q><K><S><S><T><T><T><T><P><V><Q><S><G><A><N><V><V><K><L><T><G><G><G><G><N><V><T><L><T><L><P><V><N><N><L><V><N><A><S><D><T><G><A><P><T><Q><L><L><T><E><S><P><P><T><P><L><S><K><T><N><K><K><A><R><K><K><S><L><P><A><S><Q><P><P><V><A><V><A><E><Q><V><E><T><V><L><I><E><T><T><A><D><N><I><I><Q><A><G><N><N><L><L><I><V><Q><S><P><G><G><G><Q><P><A><V><V><Q><Q><V><Q><V><V><P><P><K><A><E><Q><Q><Q><V><V><Q><I><P><Q><Q><A><L><R><V><V><Q><A><A><S><A><T><L><P><T><V><P><Q><K><P><S><Q><N><F><Q><I><Q><A><A><E><P><T><P><T><Q><V><Y><I><R><T><P><S><G><E><V><Q><T><V><L><V><Q><D><S><P><P><A><T><A><A><A><T><S><N><T><T><C><S><S><P><A><S><R><A><P><H><L><S><G><T><S><K><K><H><S><A><A><I><L><R><K><E><R><P><L><P><K><I><A><P><A><G><S><I><I><S><L><N><A><A><Q><L><A><A><A><A><Q><A><M><Q><T><I><N><I><N><G><V><Q><V><Q><G><V><P><V><T><I><T><N><T><G><G><Q><Q><Q><L><T><V><Q><N><V><S><G><N><N><L><T><I><S><G><L><S><P><T><Q><I><Q><L><Q><M><E><Q><A><L><A><G><E><T><Q><P><G><E><K><R><R><R><M><A><C><T><C><P><N><C><K><D><G><E><K><R><S><G><E><Q><G><K><K><K><H><V><C><H><I><P><D><C><G><K><T><F><R><K><T><S><L><L><R><A><H><V><R><L><H><T><G><E><R><P><F><V><C><N><W><F><F><C><G><K><R><F><T><R><S><D><E><L><Q><R><H><A><R><T><H><T><G><D><K><R><F><E><C><A><Q><C><Q><K><R><F><M><R><S><D><H><L><T><K><H><Y><K><T><H><L><V><T><K><N><L>
Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.<BOP>
Q02086
A6NHA9
O4C46_HUMAN
Olfactory receptor 4C46
Homo
<M><E><N><R><N><N><M><T><E><F><V><L><L><G><L><T><E><N><P><K><M><Q><K><I><I><F><V><V><F><F><V><I><Y><I><I><T><V><V><G><Y><V><L><I><V><V><T><I><T><A><S><P><S><L><G><S><P><M><Y><L><S><L><A><Y><L><S><F><I><D><A><C><Y><S><S><V><N><T><P><N><L><I><T><H><S><L><Y><G><K><K><A><I><L><F><N><G><C><M><T><Q><V><F><G><E><H><F><F><G><G><A><E><G><I><L><L><T><V><M><A><Y><D><H><Y><V><A><I><C><K><P><L><H><Y><M><T><I><M><N><Q><C><V><C><A><L><L><M><G><V><V><W><M><G><G><F><L><H><A><T><I><Q><I><L><F><I><F><Q><L><P><F><C><G><P><N><V><I><D><H><F><M><C><D><L><N><P><L><L><N><L><A><C><T><D><T><H><M><L><E><L><F><I><A><A><N><S><G><F><I><C><L><L><N><F><A><L><L><L><V><S><Y><V><V><I><L><C><S><L><R><T><H><S><L><E><A><R><H><K><A><L><S><T><C><V><S><H><I><T><V><V><I><L><F><F><V><P><C><I><F><V><Y><M><R><P><A><A><T><L><P><I><D><K><A><V><A><I><F><Y><T><M><I><T><P><M><L><N><P><L><I><Y><T><L><K><N><A><Q><M><K><N><A><I><R><K><L><C><S><R><K><D><I><S><G><D><K>
Odorant receptor.<BOP>
A6NHA9
P17481
HXB8_HUMAN
Homeobox protein Hox-2D
Homo
<M><S><S><Y><F><V><N><S><L><F><S><K><Y><K><T><G><E><S><L><R><P><N><Y><Y><D><C><G><F><A><Q><D><L><G><G><R><P><T><V><V><Y><G><P><S><S><G><G><S><F><Q><H><P><S><Q><I><Q><E><F><Y><H><G><P><S><S><L><S><T><A><P><Y><Q><Q><N><P><C><A><V><A><C><H><G><D><P><G><N><F><Y><G><Y><D><P><L><Q><R><Q><S><L><F><G><A><Q><D><P><D><L><V><Q><Y><A><D><C><K><L><A><A><A><S><G><L><G><E><E><A><E><G><S><E><Q><S><P><S><P><T><Q><L><F><P><W><M><R><P><Q><A><A><A><G><R><R><R><G><R><Q><T><Y><S><R><Y><Q><T><L><E><L><E><K><E><F><L><F><N><P><Y><L><T><R><K><R><R><I><E><V><S><H><A><L><G><L><T><E><R><Q><V><K><I><W><F><Q><N><R><R><M><K><W><K><K><E><N><N><K><D><K><F><P><S><S><K><C><E><Q><E><E><L><E><K><Q><K><L><E><R><A><P><E><A><A><D><E><G><D><A><Q><K><G><D><K><K>
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP>
P17481
Q86VN1
VPS36_HUMAN
ESCRT-II complex subunit VPS36
Homo
<M><D><R><F><V><W><T><S><G><L><L><E><I><N><E><T><L><V><I><Q><Q><R><G><V><R><I><Y><D><G><E><E><K><I><K><F><D><A><G><T><L><L><L><S><T><H><R><L><I><W><R><D><Q><K><N><H><E><C><C><M><A><I><L><L><S><Q><I><V><F><I><E><E><Q><A><A><G><I><G><K><S><A><K><I><V><V><H><L><H><P><A><P><P><N><K><E><P><G><P><F><Q><S><S><K><N><S><Y><I><K><L><S><F><K><E><H><G><Q><I><E><F><Y><R><R><L><S><E><E><M><T><Q><R><R><W><E><N><M><P><V><S><Q><S><L><Q><T><N><R><G><P><Q><P><G><R><I><R><A><V><G><I><V><G><I><E><R><K><L><E><E><K><R><K><E><T><D><K><N><I><S><E><A><F><E><D><L><S><K><L><M><I><K><A><K><E><M><V><E><L><S><K><S><I><A><N><K><I><K><D><K><Q><G><D><I><T><E><D><E><T><I><R><F><K><S><Y><L><L><S><M><G><I><A><N><P><V><T><R><E><T><Y><G><S><G><T><Q><Y><H><M><Q><L><A><K><Q><L><A><G><I><L><Q><V><P><L><E><E><R><G><G><I><M><S><L><T><E><V><Y><C><L><V><N><R><A><R><G><M><E><L><L><S><P><E><D><L><V><N><A><C><K><M><L><E><A><L><K><L><P><L><R><L><R><V><F><D><S><G><V><M><V><I><E><L><Q><S><H><K><E><E><E><M><V><A><S><A><L><E><T><V><S><E><K><G><S><L><T><S><E><E><F><A><K><L><V><G><M><S><V><L><L><A><K><E><R><L><L><L><A><E><K><M><G><H><L><C><R><D><D><S><V><E><G><L><R><F><Y><P><N><L><F><M><T><Q><S>
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.<BOP>
Q86VN1
Q5T4B2
GT253_HUMAN
Cerebral endothelial cell adhesion molecule
Homo
<M><R><A><A><R><A><A><P><L><L><Q><L><L><L><L><L><G><P><W><L><E><A><A><G><V><A><E><S><P><L><P><A><V><V><L><A><I><L><A><R><N><A><E><H><S><L><P><H><Y><L><G><A><L><E><R><L><D><Y><P><R><A><R><M><A><L><W><C><A><T><D><H><N><V><D><N><T><T><E><M><L><Q><E><W><L><A><A><V><G><D><D><Y><A><A><V><V><W><R><P><E><G><E><P><R><F><Y><P><D><E><E><G><P><K><H><W><T><K><E><R><H><Q><F><L><M><E><L><K><Q><E><A><L><T><F><A><R><N><W><G><A><D><Y><I><L><F><A><D><T><D><N><I><L><T><N><N><Q><T><L><R><L><L><M><G><Q><G><L><P><V><V><A><P><M><L><D><S><Q><T><Y><Y><S><N><F><W><C><G><I><T><P><Q><G><Y><Y><R><R><T><A><E><Y><F><P><T><K><N><R><Q><R><R><G><C><F><R><V><P><M><V><H><S><T><F><L><A><S><L><R><A><E><G><A><D><Q><L><A><F><Y><P><P><H><P><N><Y><T><W><P><F><D><D><I><I><V><F><A><Y><A><C><Q><A><A><G><V><S><V><H><V><C><N><E><H><R><Y><G><Y><M><N><V><P><V><K><S><H><Q><G><L><E><D><E><R><V><N><F><I><H><L><I><L><E><A><L><V><D><G><P><R><M><Q><A><S><A><H><V><T><R><P><S><K><R><P><S><K><I><G><F><D><E><V><F><V><I><S><L><A><R><R><P><D><R><R><E><R><M><L><A><S><L><W><E><M><E><I><S><G><R><V><V><D><A><V><D><G><W><M><L><N><S><S><A><I><R><N><L><G><V><D><L><L><P><G><Y><Q><D><P><Y><S><G><R><T><L><T><K><G><E><V><G><C><F><L><S><H><Y><S><I><W><E><E><V><V><A><R><G><L><A><R><V><L><V><F><E><D><D><V><R><F><E><S><N><F><R><G><R><L><E><R><L><M><E><D><V><E><A><E><K><L><S><W><D><L><I><Y><L><G><R><K><Q><V><N><P><E><K><E><T><A><V><E><G><L><P><G><L><V><V><A><G><Y><S><Y><W><T><L><A><Y><A><L><R><L><A><G><A><R><K><L><L><A><S><Q><P><L><R><R><M><L><P><V><D><E><F><L><P><I><M><F><D><Q><H><P><N><E><Q><Y><K><A><H><F><W><P><R><D><L><V><A><F><S><A><Q><P><L><L><A><A><P><T><H><Y><A><G><D><A><E><W><L><S><D><T><E><T><S><S><P><W><D><D><D><S><G><R><L><I><S><W><S><G><S><Q><K><T><L><R><S><P><R><L><D><L><T><G><S><S><G><H><S><L><Q><P><Q><P><R><D><E><L>
Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro.<BOP>
Q5T4B2
Q8N1S5
S39AB_HUMAN
Zrt- and Irt-like protein 11
Homo
<M><L><Q><G><H><S><S><V><F><Q><A><L><L><G><T><F><F><T><W><G><M><T><A><A><G><A><A><L><V><F><V><F><S><S><G><Q><R><R><I><L><D><G><S><L><G><F><A><A><G><V><M><L><A><A><S><Y><W><S><L><L><A><P><A><V><E><M><A><T><S><S><G><G><F><G><A><F><A><F><F><P><V><A><V><G><F><T><L><G><A><A><F><V><Y><L><A><D><L><L><M><P><H><L><G><A><A><E><D><P><Q><T><T><L><A><L><N><F><G><S><T><L><M><K><K><K><S><D><P><E><G><P><A><L><L><F><P><E><S><E><L><S><I><R><I><G><R><A><G><L><L><S><D><K><S><E><N><G><E><A><Y><Q><R><K><K><A><A><A><T><G><L><P><E><G><P><A><V><P><V><P><S><R><G><N><L><A><Q><P><G><G><S><S><W><R><R><I><A><L><L><I><L><A><I><T><I><H><N><V><P><E><G><L><A><V><G><V><G><F><G><A><I><E><K><T><A><S><A><T><F><E><S><A><R><N><L><A><I><G><I><G><I><Q><N><F><P><E><G><L><A><V><S><L><P><L><R><G><A><G><F><S><T><W><R><A><F><W><Y><G><Q><L><S><G><M><V><E><P><L><A><G><V><F><G><A><F><A><V><V><L><A><E><P><I><L><P><Y><A><L><A><F><A><A><G><A><M><V><Y><V><V><M><D><D><I><I><P><E><A><Q><I><S><G><N><G><K><L><A><S><W><A><S><I><L><G><F><V><V><M><M><S><L><D><V><G><L><G>
Functions as a cellular zinc transporter.<BOP>
Q8N1S5
Q15612
OR1Q1_HUMAN
Olfactory receptor TPCR106
Homo
<M><D><N><S><N><W><T><S><V><S><H><F><V><L><L><G><I><S><T><H><P><E><E><Q><I><P><L><F><L><V><F><S><L><M><Y><A><I><N><I><S><G><N><L><A><I><I><T><L><I><L><S><A><P><R><L><H><I><P><M><Y><I><F><L><S><N><L><A><L><T><D><I><C><F><T><S><T><T><V><P><K><M><L><Q><I><I><F><S><P><T><K><V><I><S><Y><T><G><C><L><A><Q><T><Y><F><F><I><C><F><A><V><M><E><N><F><I><L><A><V><M><A><Y><D><R><Y><I><A><I><C><H><P><F><H><Y><T><M><I><L><T><R><M><L><C><V><K><M><V><V><M><C><H><A><L><S><H><L><H><A><M><L><H><T><F><L><I><G><Q><L><I><F><C><A><D><N><R><I><P><H><F><F><C><D><L><Y><A><L><M><K><I><S><C><T><S><T><Y><L><N><T><L><M><I><H><T><E><G><A><V><V><I><S><G><A><L><A><F><I><T><A><S><Y><A><C><I><I><L><V><V><L><R><I><P><S><A><K><G><R><W><K><T><F><S><T><C><G><S><H><L><T><V><V><A><I><F><Y><G><T><L><S><W><V><Y><F><R><P><L><S><S><Y><S><V><T><K><G><R><I><I><T><V><V><Y><T><V><V><T><P><M><L><N><P><F><I><Y><S><L><R><N><G><D><V><K><G><G><F><M><K><W><M><S><R><M><Q><T><F><F><F><R>
Odorant receptor.<BOP>
Q15612
Q68D85
NR3L1_HUMAN
B7 homolog 6
Homo
<M><T><W><R><A><A><A><S><T><C><A><A><L><L><I><L><L><W><A><L><T><T><E><G><D><L><K><V><E><M><M><A><G><G><T><Q><I><T><P><L><N><D><N><V><T><I><F><C><N><I><F><Y><S><Q><P><L><N><I><T><S><M><G><I><T><W><F><W><K><S><L><T><F><D><K><E><V><K><V><F><E><F><F><G><D><H><Q><E><A><F><R><P><G><A><I><V><S><P><W><R><L><K><S><G><D><A><S><L><R><L><P><G><I><Q><L><E><E><A><G><E><Y><R><C><E><V><V><V><T><P><L><K><A><Q><G><T><V><Q><L><E><V><V><A><S><P><A><S><R><L><L><L><D><Q><V><G><M><K><E><N><E><D><K><Y><M><C><E><S><S><G><F><Y><P><E><A><I><N><I><T><W><E><K><Q><T><Q><K><F><P><H><P><I><E><I><S><E><D><V><I><T><G><P><T><I><K><N><M><D><G><T><F><N><V><T><S><C><L><K><L><N><S><S><Q><E><D><P><G><T><V><Y><Q><C><V><V><R><H><A><S><L><H><T><P><L><R><S><N><F><T><L><T><A><A><R><H><S><L><S><E><T><E><K><T><D><N><F><S><I><H><W><W><P><I><S><F><I><G><V><G><L><V><L><L><I><V><L><I><P><W><K><K><I><C><N><K><S><S><S><A><Y><T><P><L><K><C><I><L><K><H><W><N><S><F><D><T><Q><T><L><K><K><E><H><L><I><F><F><C><T><R><A><W><P><S><Y><Q><L><Q><D><G><E><A><W><P><P><E><G><S><V><N><I><N><T><I><Q><Q><L><D><V><F><C><R><Q><E><G><K><W><S><E><V><P><Y><V><Q><A><F><F><A><L><R><D><N><P><D><L><C><Q><C><C><R><I><D><P><A><L><L><T><V><T><S><G><K><S><I><D><D><N><S><T><K><S><E><K><Q><T><P><R><E><H><S><D><A><V><P><D><A><P><I><L><P><V><S><P><I><W><E><P><P><P><A><T><T><S><T><T><P><V><L><S><S><Q><P><P><T><L><L><L><P><L><Q>
Triggers NCR3-dependent natural killer cell activation.<BOP>
Q68D85
Q96LC9
BMF_HUMAN
Bcl-2-modifying factor
Homo
<M><E><P><S><Q><C><V><E><E><L><E><D><D><V><F><Q><P><E><D><G><E><P><V><T><Q><P><G><S><L><L><S><A><D><L><F><A><Q><S><L><L><D><C><P><L><S><R><L><Q><L><F><P><L><T><H><C><C><G><P><G><L><R><P><T><S><Q><E><D><K><A><T><Q><T><L><S><P><A><S><P><S><Q><G><V><M><L><P><C><G><V><T><E><E><P><Q><R><L><F><Y><G><N><A><G><Y><R><L><P><L><P><A><S><F><P><A><V><L><P><I><G><E><Q><P><P><E><G><Q><W><Q><H><Q><A><E><V><Q><I><A><R><K><L><Q><C><I><A><D><Q><F><H><R><L><H><V><Q><Q><H><Q><Q><N><Q><N><R><V><W><W><Q><I><L><L><F><L><H><N><L><A><L><N><G><E><E><N><R><N><G><A><G><P><R>
May play a role in apoptosis. Isoform 1 seems to be the main initiator.<BOP>
Q96LC9
Q08AI6
S38AB_HUMAN
Solute carrier family 38 member 11
Homo
<M><K><Q><A><G><F><P><L><G><I><L><L><L><F><W><V><S><Y><V><T><D><F><S><L><V><L><L><I><K><G><G><A><L><S><G><T><D><T><Y><Q><S><L><V><N><K><T><F><G><F><P><G><Y><L><L><L><S><V><L><Q><F><L><Y><P><F><I><A><M><I><S><Y><N><I><I><A><G><D><T><L><S><K><V><F><Q><R><I><P><G><V><D><P><E><N><V><F><I><G><R><H><F><I><I><G><L><S><T><V><T><F><T><L><P><L><S><L><Y><R><N><I><A><K><L><G><K><V><S><L><I><S><T><G><L><T><T><L><I><L><G><I><V><M><A><R><A><I><S><L><G><P><H><I><P><K><T><E><D><A><W><V><F><A><K><P><N><A><I><Q><A><V><G><V><M><S><F><A><F><I><C><H><H><N><S><F><L><V><Y><S><S><L><E><E><P><T><V><A><K><W><S><R><L><I><H><M><S><I><V><I><S><V><F><I><C><I><F><F><A><T><C><G><Y><L><T><F><T><G><F><T><Q><G><D><L><F><E><N><Y><C><R><N><D><D><L><V><T><F><G><R><F><C><Y><G><V><T><V><I><L><T><Y><P><M><E><C><F><V><T><R><E><V><I><A><N><V><F><F><G><G><N><L><S><S><V><F><H><I><V><V><T><V><M><V><I><T><V><A><T><L><V><S><L><L><I><D><C><L><G><I><V><L><E><L><N><G><V><L><C><A><T><P><L><I><F><I><I><P><S><A><C><Y><L><K><L><S><E><E><P><R><T><H><S><D><K><I><M><S><C><V><M><L><P><I><G><A><V><V><M><V><F><G><F><V><M><A><I><T><N><T><Q><D><C><T><H><G><Q><E><M><F><Y><C><F><P><D><N><F><S><L><T><N><T><S><E><S><H><V><Q><Q><T><T><Q><L><S><T><L><N><I><S><I><F><Q>
Putative sodium-dependent amino acid/proton antiporter.<BOP>
Q08AI6
O75629
CREG1_HUMAN
Cellular repressor of E1A-stimulated genes 1
Homo
<M><A><G><L><S><R><G><S><A><R><A><L><L><A><A><L><L><A><S><T><L><L><A><L><L><V><S><P><A><R><G><R><G><G><R><D><H><G><D><W><D><E><A><S><R><L><P><P><L><P><P><R><E><D><A><A><R><V><A><R><F><V><T><H><V><S><D><W><G><A><L><A><T><I><S><T><L><E><A><V><R><G><R><P><F><A><D><V><L><S><L><S><D><G><P><P><G><A><G><S><G><V><P><Y><F><Y><L><S><P><L><Q><L><S><V><S><N><L><Q><E><N><P><Y><A><T><L><T><M><T><L><A><Q><T><N><F><C><K><K><H><G><F><D><P><Q><S><P><L><C><V><H><I><M><L><S><G><T><V><T><K><V><N><E><T><E><M><D><I><A><K><H><S><L><F><I><R><H><P><E><M><K><T><W><P><S><S><H><N><W><F><F><A><K><L><N><I><T><N><I><W><V><L><D><Y><F><G><G><P><K><I><V><T><P><E><E><Y><Y><N><V><T><V><Q>
May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.<BOP>
O75629
O75381
PEX14_HUMAN
Peroxisomal membrane anchor protein PEX14
Homo
<M><A><S><S><E><Q><A><E><Q><P><S><Q><P><S><S><T><P><G><S><E><N><V><L><P><R><E><P><L><I><A><T><A><V><K><F><L><Q><N><S><R><V><R><Q><S><P><L><A><T><R><R><A><F><L><K><K><K><G><L><T><D><E><E><I><D><M><A><F><Q><Q><S><G><T><A><A><D><E><P><S><S><L><G><P><A><T><Q><V><V><P><V><Q><P><P><H><L><I><S><Q><P><Y><S><P><A><G><S><R><W><R><D><Y><G><A><L><A><I><I><M><A><G><I><A><F><G><F><H><Q><L><Y><K><K><Y><L><L><P><L><I><L><G><G><R><E><D><R><K><Q><L><E><R><M><E><A><G><L><S><E><L><S><G><S><V><A><Q><T><V><T><Q><L><Q><T><T><L><A><S><V><Q><E><L><L><I><Q><Q><Q><Q><K><I><Q><E><L><A><H><E><L><A><A><A><K><A><T><T><S><T><N><W><I><L><E><S><Q><N><I><N><E><L><K><S><E><I><N><S><L><K><G><L><L><L><N><R><R><Q><F><P><P><S><P><S><A><P><K><I><P><S><W><Q><I><P><V><K><S><P><S><P><S><S><P><A><A><V><N><H><H><S><S><S><D><I><S><P><V><S><N><E><S><T><S><S><S><P><G><K><E><G><H><S><P><E><G><S><T><V><T><Y><H><L><L><G><P><Q><E><E><G><E><G><V><V><D><V><K><G><Q><V><R><M><E><V><Q><G><E><E><E><K><R><E><D><K><E><D><E><E><D><E><E><D><D><D><V><S><H><V><D><E><E><D><C><L><G><V><Q><R><E><D><R><R><G><G><D><G><Q><I><N><E><Q><V><E><K><L><R><R><P><E><G><A><S><N><E><S><E><R><D>
Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.<BOP>
O75381
P07438
MT1B_HUMAN
Metallothionein-IB
Homo
<M><D><P><N><C><S><C><T><T><G><G><S><C><A><C><A><G><S><C><K><C><K><E><C><K><C><T><S><C><K><K><C><C><C><S><C><C><P><V><G><C><A><K><C><A><Q><G><C><V><C><K><G><S><S><E><K><C><R><C><C><A>
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.<BOP>
P07438
O15321
TM9S1_HUMAN
MP70 protein family member
Homo
<M><T><V><V><G><N><P><R><S><W><S><C><Q><W><L><P><I><L><I><L><L><L><G><T><G><H><G><P><G><V><E><G><V><T><H><Y><K><A><G><D><P><V><I><L><Y><V><N><K><V><G><P><Y><H><N><P><Q><E><T><Y><H><Y><Y><Q><L><P><V><C><C><P><E><K><I><R><H><K><S><L><S><L><G><E><V><L><D><G><D><R><M><A><E><S><L><Y><E><I><R><F><R><E><N><V><E><K><R><I><L><C><H><M><Q><L><S><S><A><Q><V><E><Q><L><R><Q><A><I><E><E><L><Y><Y><F><E><F><V><V><D><D><L><P><I><R><G><F><V><G><Y><M><E><E><S><G><F><L><P><H><S><H><K><I><G><L><W><T><H><L><D><F><H><L><E><F><H><G><D><R><I><I><F><A><N><V><S><V><R><D><V><K><P><H><S><L><D><G><L><R><P><D><E><F><L><G><L><T><H><T><Y><S><V><R><W><S><E><T><S><V><E><R><R><S><D><R><R><R><G><D><D><G><G><F><F><P><R><T><L><E><I><H><W><L><S><I><I><N><S><M><V><L><V><F><L><L><V><G><F><V><A><V><I><L><M><R><V><L><R><N><D><L><A><R><Y><N><L><D><E><E><T><T><S><A><G><S><G><D><D><F><D><Q><G><D><N><G><W><K><I><I><H><T><D><V><F><R><F><P><P><Y><R><G><L><L><C><A><V><L><G><V><G><A><Q><F><L><A><L><G><T><G><I><I><V><M><A><L><L><G><M><F><N><V><H><R><H><G><A><I><N><S><A><A><I><L><L><Y><A><L><T><C><C><I><S><G><Y><V><S><S><H><F><Y><R><Q><I><G><G><E><R><W><V><W><N><I><I><L><T><T><S><L><F><S><V><P><F><F><L><T><W><S><V><V><N><S><V><H><W><A><N><G><S><T><Q><A><L><P><A><T><T><I><L><L><L><L><T><V><W><L><L><V><G><F><P><L><T><V><I><G><G><I><F><G><K><N><N><A><S><P><F><D><A><P><C><R><T><K><N><I><A><R><E><I><P><P><Q><P><W><Y><K><S><T><V><I><H><M><T><V><G><G><F><L><P><F><S><A><I><S><V><E><L><Y><Y><I><F><A><T><V><W><G><R><E><Q><Y><T><L><Y><G><I><L><F><F><V><F><A><I><L><L><S><V><G><A><C><I><S><I><A><L><T><Y><F><Q><L><S><G><E><D><Y><R><W><W><W><R><S><V><L><S><V><G><S><T><G><L><F><I><F><L><Y><S><V><F><Y><Y><A><R><R><S><N><M><S><G><A><V><Q><T><V><E><F><F><G><Y><S><L><L><T><G><Y><V><F><F><L><M><L><G><T><I><S><F><F><S><S><L><K><F><I><R><Y><I><Y><V><N><L><K><M><D>
Plays an essential role in autophagy.<BOP>
O15321
Q9H9S5
FKRP_HUMAN
Ribitol-5-phosphate transferase
Homo
<M><R><L><T><R><C><Q><A><A><L><A><A><A><I><T><L><N><L><L><V><L><F><Y><V><S><W><L><Q><H><Q><P><R><N><S><R><A><R><G><P><R><R><A><S><A><A><G><P><R><V><T><V><L><V><R><E><F><E><A><F><D><N><A><V><P><E><L><V><D><S><F><L><Q><Q><D><P><A><Q><P><V><V><V><A><A><D><T><L><P><Y><P><P><L><A><L><P><R><I><P><N><V><R><L><A><L><L><Q><P><A><L><D><R><P><A><A><A><S><R><P><E><T><Y><V><A><T><E><F><V><A><L><V><P><D><G><A><R><A><E><A><P><G><L><L><E><R><M><V><E><A><L><R><A><G><S><A><R><L><V><A><A><P><V><A><T><A><N><P><A><R><C><L><A><L><N><V><S><L><R><E><W><T><A><R><Y><G><A><A><P><A><A><P><R><C><D><A><L><D><G><D><A><V><V><L><L><R><A><R><D><L><F><N><L><S><A><P><L><A><R><P><V><G><T><S><L><F><L><Q><T><A><L><R><G><W><A><V><Q><L><L><D><L><T><F><A><A><A><R><Q><P><P><L><A><T><A><H><A><R><W><K><A><E><R><E><G><R><A><R><R><A><A><L><L><R><A><L><G><I><R><L><V><S><W><E><G><G><R><L><E><W><F><G><C><N><K><E><T><T><R><C><F><G><T><V><V><G><D><T><P><A><Y><L><Y><E><E><R><W><T><P><P><C><C><L><R><A><L><R><E><T><A><R><Y><V><V><G><V><L><E><A><A><G><V><R><Y><W><L><E><G><G><S><L><L><G><A><A><R><H><G><D><I><I><P><W><D><Y><D><V><D><L><G><I><Y><L><E><D><V><G><N><C><E><Q><L><R><G><A><E><A><G><S><V><V><D><E><R><G><F><V><W><E><K><A><V><E><G><D><F><F><R><V><Q><Y><S><E><S><N><H><L><H><V><D><L><W><P><F><Y><P><R><N><G><V><M><T><K><D><T><W><L><D><H><R><Q><D><V><E><F><P><E><H><F><L><Q><P><L><V><P><L><P><F><A><G><F><V><A><Q><A><P><N><N><Y><R><R><F><L><E><L><K><F><G><P><G><V><I><E><N><P><Q><Y><P><N><P><A><L><L><S><L><T><G><S><G>
Catalyzes the transfer of a ribitol 5-phosphate from CDP-L-ribitol to the ribitol 5-phosphate previously attached by FKTN/fukutin to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) . This constitutes the second step in the formation of the ribose 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 .<BOP>
Q9H9S5
Q6PIZ9
TRAT1_HUMAN
pp29/30
Homo
<M><S><G><I><S><G><C><P><F><F><L><W><G><L><L><A><L><L><G><L><A><L><V><I><S><L><I><F><N><I><S><H><Y><V><E><K><Q><R><Q><D><K><M><Y><S><Y><S><S><D><H><T><R><V><D><E><Y><Y><I><E><D><T><P><I><Y><G><N><L><D><D><M><I><S><E><P><M><D><E><N><C><Y><E><Q><M><K><A><R><P><E><K><S><V><N><K><M><Q><E><A><T><P><S><A><Q><A><T><N><E><T><Q><M><C><Y><A><S><L><D><H><S><V><K><G><K><R><R><K><P><R><K><Q><N><T><H><F><S><D><K><D><G><D><E><Q><L><H><A><I><D><A><S><V><S><K><T><T><L><V><D><S><F><S><P><E><S><Q><A><V><E><E><N><I><H><D><D><P><I><R><L><F><G><L><I><R><A><K><R><E><P><I><N>
Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.<BOP>
Q6PIZ9
Q8NGP2
OR8J1_HUMAN
Olfactory receptor OR11-183
Homo
<M><A><P><E><N><F><T><R><V><T><E><F><I><L><T><G><V><S><S><C><P><E><L><Q><I><P><L><F><L><V><F><L><V><L><Y><G><L><T><M><A><G><N><L><G><I><I><T><L><T><S><V><D><S><R><L><Q><T><P><M><Y><F><F><L><Q><H><L><A><L><I><N><L><G><N><S><T><V><I><A><P><K><M><L><I><N><F><L><V><K><K><K><T><T><S><F><Y><E><C><A><T><Q><L><G><G><F><L><F><F><I><V><S><E><V><I><M><L><A><L><M><A><Y><D><R><Y><V><A><I><C><N><P><L><L><Y><M><V><V><V><S><R><R><L><C><L><L><L><V><S><L><T><Y><L><Y><G><F><S><T><A><I><V><V><S><S><Y><V><F><S><V><S><Y><C><S><S><N><I><I><N><H><F><Y><C><D><N><V><P><L><L><A><L><S><C><S><D><T><Y><L><P><E><T><V><V><F><I><S><A><A><T><N><V><V><G><S><L><I><I><V><L><V><S><Y><F><N><I><V><L><S><I><L><K><I><C><S><S><E><G><R><K><K><A><F><S><T><C><A><S><H><M><M><A><V><T><I><F><Y><G><T><L><L><F><M><Y><V><Q><P><R><S><N><H><S><L><D><T><D><D><K><M><A><S><V><F><Y><T><L><V><I><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><K><T><A><L><Q><R><F><M><T><N><L><C><Y><S><F><K><T><M>
Odorant receptor.<BOP>
Q8NGP2
Q96JW4
S41A2_HUMAN
Solute carrier family 41 member 2
Homo
<M><T><N><S><K><G><R><S><I><T><D><K><T><S><G><G><P><S><S><G><G><G><F><V><D><W><T><L><R><L><N><T><I><Q><S><D><K><F><L><N><L><L><L><S><M><V><P><V><I><Y><Q><K><N><Q><E><D><R><H><K><K><A><N><G><I><W><Q><D><G><L><S><T><A><V><Q><T><F><S><N><R><S><E><Q><H><M><E><Y><H><S><F><S><E><Q><S><F><H><A><N><N><G><H><A><S><S><S><C><S><Q><K><Y><D><D><Y><A><N><Y><N><Y><C><D><G><R><E><T><S><E><T><T><A><M><L><Q><D><E><D><I><S><S><D><G><D><E><D><A><I><V><E><V><T><P><K><L><P><K><E><S><S><G><I><M><A><L><Q><I><L><V><P><F><L><L><A><G><F><G><T><V><S><A><G><M><V><L><D><I><V><Q><H><W><E><V><F><R><K><V><T><E><V><F><I><L><V><P><A><L><L><G><L><K><G><N><L><E><M><T><L><A><S><R><L><S><T><A><V><N><I><G><K><M><D><S><P><I><E><K><W><N><L><I><I><G><N><L><A><L><K><Q><V><Q><A><T><V><V><G><F><L><A><A><V><A><A><I><I><L><G><W><I><P><E><G><K><Y><Y><L><D><H><S><I><L><L><C><S><S><S><V><A><T><A><F><I><A><S><L><L><Q><G><I><I><M><V><G><V><I><V><G><S><K><K><T><G><I><N><P><D><N><V><A><T><P><I><A><A><S><F><G><D><L><I><T><L><A><I><L><A><W><I><S><Q><G><L><Y><S><C><L><E><T><Y><Y><Y><I><S><P><L><V><G><V><F><F><L><A><L><T><P><I><W><I><I><I><A><A><K><H><P><A><T><R><T><V><L><H><S><G><W><E><P><V><I><T><A><M><V><I><S><S><I><G><G><L><I><L><D><T><T><V><S><D><P><N><L><V><G><I><V><V><Y><T><P><V><I><N><G><I><G><G><N><L><V><A><I><Q><A><S><R><I><S><T><Y><L><H><L><H><S><I><P><G><E><L><P><D><E><P><K><G><C><Y><Y><P><F><R><T><F><F><G><P><G><V><N><N><K><S><A><Q><V><L><L><L><L><V><I><P><G><H><L><I><F><L><Y><T><I><H><L><M><K><S><G><H><T><S><L><T><I><I><F><I><V><V><Y><L><F><G><A><V><L><Q><V><F><T><L><L><W><I><A><D><W><M><V><H><H><F><W><R><K><G><K><D><P><D><S><F><S><I><P><Y><L><T><A><L><G><D><L><L><G><T><A><L><L><A><L><S><F><H><F><L><W><L><I><G><D><R><D><G><D><V><G><D>
Acts as a plasma-membrane magnesium transporter.<BOP>
Q96JW4
Q96BT7
ALKB8_HUMAN
tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8
Homo
<M><D><S><N><H><Q><S><N><Y><K><L><S><K><T><E><K><K><F><L><R><K><Q><I><K><A><K><H><T><L><L><R><H><E><G><I><E><T><V><S><Y><A><T><Q><S><L><V><V><A><N><G><G><L><G><N><G><V><S><R><N><Q><L><L><P><V><L><E><K><C><G><L><V><D><A><L><L><M><P><P><N><K><P><Y><S><F><A><R><Y><R><T><T><E><E><S><K><R><A><Y><V><T><L><N><G><K><E><V><V><D><D><L><G><Q><K><I><T><L><Y><L><N><F><V><E><K><V><Q><W><K><E><L><R><P><Q><A><L><P><P><G><L><M><V><V><E><E><I><I><S><S><E><E><E><K><M><L><L><E><S><V><D><W><T><E><D><T><D><N><Q><N><S><Q><K><S><L><K><H><R><R><V><K><H><F><G><Y><E><F><H><Y><E><N><N><N><V><D><K><D><K><P><L><S><G><G><L><P><D><I><C><E><S><F><L><E><K><W><L><R><K><G><Y><I><K><H><K><P><D><Q><M><T><I><N><Q><Y><E><P><G><Q><G><I><P><A><H><I><D><T><H><S><A><F><E><D><E><I><V><S><L><S><L><G><S><E><I><V><M><D><F><K><H><P><D><G><I><A><V><P><V><M><L><P><R><R><S><L><L><V><M><T><G><E><S><R><Y><L><W><T><H><G><I><T><C><R><K><F><D><T><V><Q><A><S><E><S><L><K><S><G><I><I><T><S><D><V><G><D><L><T><L><S><K><R><G><L><R><T><S><F><T><F><R><K><V><R><Q><T><P><C><N><C><S><Y><P><L><V><C><D><S><Q><R><K><E><T><P><P><S><F><P><E><S><D><K><E><A><S><R><L><E><Q><E><Y><V><H><Q><V><Y><E><E><I><A><G><H><F><S><S><T><R><H><T><P><W><P><H><I><V><E><F><L><K><A><L><P><S><G><S><I><V><A><D><I><G><C><G><N><G><K><Y><L><G><I><N><K><E><L><Y><M><I><G><C><D><R><S><Q><N><L><V><D><I><C><R><E><R><Q><F><Q><A><F><V><C><D><A><L><A><V><P><V><R><S><G><S><C><D><A><C><I><S><I><A><V><I><H><H><F><A><T><A><E><R><R><V><A><A><L><Q><E><I><V><R><L><L><R><P><G><G><K><A><L><I><Y><V><W><A><M><E><Q><E><Y><N><K><Q><K><S><K><Y><L><R><G><N><R><N><S><Q><G><K><K><E><E><M><N><S><D><T><S><V><Q><R><S><L><V><E><Q><M><R><D><M><G><S><R><D><S><A><S><S><V><P><R><I><N><D><S><Q><E><G><G><C><N><S><R><Q><V><S><N><S><K><L><P><V><H><V><N><R><T><S><F><Y><S><Q><D><V><L><V><P><W><H><L><K><G><N><P><D><K><G><K><P><V><E><P><F><G><P><I><G><S><Q><D><P><S><P><V><F><H><R><Y><Y><H><V><F><R><E><G><E><L><E><G><A><C><R><T><V><S><D><V><R><I><L><Q><S><Y><Y><D><Q><G><N><W><C><V><I><L><Q><K><A>
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain . Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA . Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) . Required for normal survival after DNA damage . May inhibit apoptosis and promote cell survival and angiogenesis .<BOP>
Q96BT7
P28347
TEAD1_HUMAN
Transcription factor 13
Homo
<M><E><P><S><S><W><S><G><S><E><S><P><A><E><N><M><E><R><M><S><D><S><A><D><K><P><I><D><N><D><A><E><G><V><W><S><P><D><I><E><Q><S><F><Q><E><A><L><A><I><Y><P><P><C><G><R><R><K><I><I><L><S><D><E><G><K><M><Y><G><R><N><E><L><I><A><R><Y><I><K><L><R><T><G><K><T><R><T><R><K><Q><V><S><S><H><I><Q><V><L><A><R><R><K><S><R><D><F><H><S><K><L><K><D><Q><T><A><K><D><K><A><L><Q><H><M><A><A><M><S><S><A><Q><I><V><S><A><T><A><I><H><N><K><L><G><L><P><G><I><P><R><P><T><F><P><G><A><P><G><F><W><P><G><M><I><Q><T><G><Q><P><G><S><S><Q><D><V><K><P><F><V><Q><Q><A><Y><P><I><Q><P><A><V><T><A><P><I><P><G><F><E><P><A><S><A><P><A><P><S><V><P><A><W><Q><G><R><S><I><G><T><T><K><L><R><L><V><E><F><S><A><F><L><E><Q><Q><R><D><P><D><S><Y><N><K><H><L><F><V><H><I><G><H><A><N><H><S><Y><S><D><P><L><L><E><S><V><D><I><R><Q><I><Y><D><K><F><P><E><K><K><G><G><L><K><E><L><F><G><K><G><P><Q><N><A><F><F><L><V><K><F><W><A><D><L><N><C><N><I><Q><D><D><A><G><A><F><Y><G><V><T><S><Q><Y><E><S><S><E><N><M><T><V><T><C><S><T><K><V><C><S><F><G><K><Q><V><V><E><K><V><E><T><E><Y><A><R><F><E><N><G><R><F><V><Y><R><I><N><R><S><P><M><C><E><Y><M><I><N><F><I><H><K><L><K><H><L><P><E><K><Y><M><M><N><S><V><L><E><N><F><T><I><L><L><V><V><T><N><R><D><T><Q><E><T><L><L><C><M><A><C><V><F><E><V><S><N><S><E><H><G><A><Q><H><H><I><Y><R><L><V><K><D>
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.<BOP>
P28347
Q14512
FGFP1_HUMAN
17 kDa heparin-binding growth factor-binding protein
Homo
<M><K><I><C><S><L><T><L><L><S><F><L><L><L><A><A><Q><V><L><L><V><E><G><K><K><K><V><K><N><G><L><H><S><K><V><V><S><E><Q><K><D><T><L><G><N><T><Q><I><K><Q><K><S><R><P><G><N><K><G><K><F><V><T><K><D><Q><A><N><C><R><W><A><A><T><E><Q><E><E><G><I><S><L><K><V><E><C><T><Q><L><D><H><E><F><S><C><V><F><A><G><N><P><T><S><C><L><K><L><K><D><E><R><V><Y><W><K><Q><V><A><R><N><L><R><S><Q><K><D><I><C><R><Y><S><K><T><A><V><K><T><R><V><C><R><K><D><F><P><E><S><S><L><K><L><V><S><S><T><L><F><G><N><T><K><P><R><K><E><K><T><E><M><S><P><R><E><H><I><K><G><K><E><T><T><P><S><S><L><A><V><T><Q><T><M><A><T><K><A><P><E><C><V><E><D><P><D><M><A><N><Q><R><K><T><A><L><E><F><C><G><E><T><W><S><S><L><C><T><F><F><L><S><I><V><Q><D><T><S><C>
Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.<BOP>
Q14512
P31785
IL2RG_HUMAN
p64
Homo
<M><L><K><P><S><L><P><F><T><S><L><L><F><L><Q><L><P><L><L><G><V><G><L><N><T><T><I><L><T><P><N><G><N><E><D><T><T><A><D><F><F><L><T><T><M><P><T><D><S><L><S><V><S><T><L><P><L><P><E><V><Q><C><F><V><F><N><V><E><Y><M><N><C><T><W><N><S><S><S><E><P><Q><P><T><N><L><T><L><H><Y><W><Y><K><N><S><D><N><D><K><V><Q><K><C><S><H><Y><L><F><S><E><E><I><T><S><G><C><Q><L><Q><K><K><E><I><H><L><Y><Q><T><F><V><V><Q><L><Q><D><P><R><E><P><R><R><Q><A><T><Q><M><L><K><L><Q><N><L><V><I><P><W><A><P><E><N><L><T><L><H><K><L><S><E><S><Q><L><E><L><N><W><N><N><R><F><L><N><H><C><L><E><H><L><V><Q><Y><R><T><D><W><D><H><S><W><T><E><Q><S><V><D><Y><R><H><K><F><S><L><P><S><V><D><G><Q><K><R><Y><T><F><R><V><R><S><R><F><N><P><L><C><G><S><A><Q><H><W><S><E><W><S><H><P><I><H><W><G><S><N><T><S><K><E><N><P><F><L><F><A><L><E><A><V><V><I><S><V><G><S><M><G><L><I><I><S><L><L><C><V><Y><F><W><L><E><R><T><M><P><R><I><P><T><L><K><N><L><E><D><L><V><T><E><Y><H><G><N><F><S><A><W><S><G><V><S><K><G><L><A><E><S><L><Q><P><D><Y><S><E><R><L><C><L><V><S><E><I><P><P><K><G><G><A><L><G><E><G><P><G><A><S><P><C><N><Q><H><S><P><Y><W><A><P><P><C><Y><T><L><K><P><E><T>
Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 .<BOP>
P31785
Q86T90
K1328_HUMAN
Protein hinderin
Homo
<M><A><D><V><A><G><P><S><R><P><S><A><A><A><F><W><S><R><D><F><S><D><E><E><Q><S><V><V><Y><V><P><G><I><S><A><E><G><N><V><R><S><R><H><K><L><M><S><P><K><A><D><V><K><L><K><T><S><R><V><T><D><A><S><I><S><M><E><S><L><K><G><T><G><D><S><V><D><E><Q><N><S><C><R><G><E><I><K><S><A><S><L><K><D><L><C><L><E><D><K><R><R><I><A><N><L><I><K><E><L><A><R><V><S><E><E><K><E><V><T><E><E><R><L><K><A><E><Q><E><S><F><E><K><K><I><R><Q><L><E><E><Q><N><E><L><I><I><K><E><R><E><A><L><Q><L><Q><Y><R><E><C><Q><E><L><L><S><L><Y><Q><K><Y><L><S><E><Q><Q><E><K><L><T><M><S><L><S><E><L><G><A><A><R><M><Q><E><Q><Q><V><S><S><R><K><S><T><L><Q><C><S><S><V><E><L><D><G><S><Y><L><S><I><A><R><P><Q><T><Y><Y><Q><T><K><Q><R><P><K><S><A><V><Q><D><S><A><S><E><S><L><I><A><F><R><N><N><S><L><K><P><V><T><L><H><H><P><K><D><D><L><D><K><I><P><S><E><T><T><T><C><N><C><E><S><P><G><R><K><P><A><V><P><T><E><K><M><P><Q><E><E><L><H><M><K><E><C><P><H><L><K><P><T><P><S><Q><C><C><G><H><R><L><A><A><D><R><V><H><D><S><H><P><T><N><M><T><P><Q><H><P><K><T><H><P><E><S><C><S><Y><C><R><L><S><W><A><S><L><V><H><G><G><G><A><L><Q><P><I><E><T><L><K><K><Q><I><S><E><D><R><K><Q><Q><L><M><L><Q><K><M><E><L><E><I><E><K><E><R><L><Q><H><L><L><A><Q><Q><E><T><K><L><L><L><K><Q><Q><Q><L><H><Q><S><R><L><D><Y><N><C><L><L><K><S><N><C><D><G><W><L><L><G><T><S><S><S><I><K><K><H><Q><D><P><P><N><S><G><E><N><R><K><E><R><K><T><V><G><F><H><S><H><M><K><D><D><A><Q><W><S><C><Q><K><K><D><T><C><R><P><Q><R><G><T><V><T><G><V><R><K><D><A><S><T><S><P><M><P><T><G><S><L><K><D><F><V><T><T><A><S><P><S><L><Q><H><T><T><S><R><Y><E><T><S><L><L><D><L><V><Q><S><L><S><P><N><S><A><P><K><P><Q><R><Y><P><S><R><E><A><G><A><W><N><H><G><T><F><R><L><S><P><L><K><S><T><R><K><K><M><G><M><H><R><T><P><E><E><L><E><E><N><Q><I><L><E><D><I><F><F><I>
Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes.<BOP>
Q86T90
Q99518
FMO2_HUMAN
Pulmonary flavin-containing monooxygenase 2
Homo
<M><A><K><K><V><A><V><I><G><A><G><V><S><G><L><I><S><L><K><C><C><V><D><E><G><L><E><P><T><C><F><E><R><T><E><D><I><G><G><V><W><R><F><K><E><N><V><E><D><G><R><A><S><I><Y><Q><S><V><V><T><N><T><S><K><E><M><S><C><F><S><D><F><P><M><P><E><D><F><P><N><F><L><H><N><S><K><L><L><E><Y><F><R><I><F><A><K><K><F><D><L><L><K><Y><I><Q><F><Q><T><T><V><L><S><V><R><K><C><P><D><F><S><S><S><G><Q><W><K><V><V><T><Q><S><N><G><K><E><Q><S><A><V><F><D><A><V><M><V><C><S><G><H><H><I><L><P><H><I><P><L><K><S><F><P><G><M><E><R><F><K><G><Q><Y><F><H><S><R><Q><Y><K><H><P><D><G><F><E><G><K><R><I><L><V><I><G><M><G><N><S><G><S><D><I><A><V><E><L><S><K><N><A><A><Q><V><F><I><S><T><R><H><G><T><W><V><M><S><R><I><S><E><D><G><Y><P><W><D><S><V><F><H><T><R><F><R><S><M><L><R><N><V><L><P><R><T><A><V><K><W><M><I><E><Q><Q><M><N><R><W><F><N><H><E><N><Y><G><L><E><P><Q><N><K><Y><I><M><K><E><P><V><L><N><D><D><V><P><S><R><L><L><C><G><A><I><K><V><K><S><T><V><K><E><L><T><E><T><S><A><I><F><E><D><G><T><V><E><E><N><I><D><V><I><I><F><A><T><G><Y><S><F><S><F><P><F><L><E><D><S><L><V><K><V><E><N><N><M><V><S><L><Y><K><Y><I><F><P><A><H><L><D><K><S><T><L><A><C><I><G><L><I><Q><P><L><G><S><I><F><P><T><A><E><L><Q><A><R><W><V><T><R><V><F><K><G><L><C><S><L><P><S><E><R><T><M><M><M><D><I><I><K><R><N><E><K><R><I><D><L><F><G><E><S><Q><S><Q><T><L><Q><T><N><Y><V><D><Y><L><D><E><L><A><L><E><I><G><A><K><P><D><F><C><S><L><L><F><K><D><P><K><L><A><V><R><L><Y><F><G><P><C><N><S><Y><Q><Y><R><L><V><G><P><G><Q><W><E><G><A><R><N><A><I><F><T><Q><K><Q><R><I><L><K><P><L><K><T><R><A><L><K><D><S><S><N><F><S><V><S><F><L><L><K><I><L><G><L><L><A><V><V><V><A><F><F><C><Q><L><Q><W><S>
Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation . Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid . In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate . Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton .<BOP>
Q99518
O95571
ETHE1_HUMAN
Sulfur dioxygenase ETHE1
Homo
<M><A><E><A><V><L><R><V><A><R><R><Q><L><S><Q><R><G><G><S><G><A><P><I><L><L><R><Q><M><F><E><P><V><S><C><T><F><T><Y><L><L><G><D><R><E><S><R><E><A><V><L><I><D><P><V><L><E><T><A><P><R><D><A><Q><L><I><K><E><L><G><L><R><L><L><Y><A><V><N><T><H><C><H><A><D><H><I><T><G><S><G><L><L><R><S><L><L><P><G><C><Q><S><V><I><S><R><L><S><G><A><Q><A><D><L><H><I><E><D><G><D><S><I><R><F><G><R><F><A><L><E><T><R><A><S><P><G><H><T><P><G><C><V><T><F><V><L><N><D><H><S><M><A><F><T><G><D><A><L><L><I><R><G><C><G><R><T><D><F><Q><Q><G><C><A><K><T><L><Y><H><S><V><H><E><K><I><F><T><L><P><G><D><C><L><I><Y><P><A><H><D><Y><H><G><F><T><V><S><T><V><E><E><E><R><T><L><N><P><R><L><T><L><S><C><E><E><F><V><K><I><M><G><N><L><N><L><P><K><P><Q><Q><I><D><F><A><V><P><A><N><M><R><C><G><V><Q><T><P><T><A>
Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus .<BOP>
O95571
Q9Y6M0
TEST_HUMAN
Serine protease 21
Homo
<M><G><A><R><G><A><L><L><L><A><L><L><L><A><R><A><G><L><R><K><P><E><S><Q><E><A><A><P><L><S><G><P><C><G><R><R><V><I><T><S><R><I><V><G><G><E><D><A><E><L><G><R><W><P><W><Q><G><S><L><R><L><W><D><S><H><V><C><G><V><S><L><L><S><H><R><W><A><L><T><A><A><H><C><F><E><T><Y><S><D><L><S><D><P><S><G><W><M><V><Q><F><G><Q><L><T><S><M><P><S><F><W><S><L><Q><A><Y><Y><T><R><Y><F><V><S><N><I><Y><L><S><P><R><Y><L><G><N><S><P><Y><D><I><A><L><V><K><L><S><A><P><V><T><Y><T><K><H><I><Q><P><I><C><L><Q><A><S><T><F><E><F><E><N><R><T><D><C><W><V><T><G><W><G><Y><I><K><E><D><E><A><L><P><S><P><H><T><L><Q><E><V><Q><V><A><I><I><N><N><S><M><C><N><H><L><F><L><K><Y><S><F><R><K><D><I><F><G><D><M><V><C><A><G><N><A><Q><G><G><K><D><A><C><F><G><D><S><G><G><P><L><A><C><N><K><N><G><L><W><Y><Q><I><G><V><V><S><W><G><V><G><C><G><R><P><N><R><P><G><V><Y><T><N><I><S><H><H><F><E><W><I><Q><K><L><M><A><Q><S><G><M><S><Q><P><D><P><S><W><P><L><L><F><F><P><L><L><W><A><L><P><L><L><G><P><V>
Could regulate proteolytic events associated with testicular germ cell maturation.<BOP>
Q9Y6M0
Q9H081
MIS12_HUMAN
Protein MIS12 homolog
Homo
<M><S><V><D><P><M><T><Y><E><A><Q><F><F><G><F><T><P><Q><T><C><M><L><R><I><Y><I><A><F><Q><D><Y><L><F><E><V><M><Q><A><V><E><Q><V><I><L><K><K><L><D><G><I><P><D><C><D><I><S><P><V><Q><I><R><K><C><T><E><K><F><L><C><F><M><K><G><H><F><D><N><L><F><S><K><M><E><Q><L><F><L><Q><L><I><L><R><I><P><S><N><I><L><L><P><E><D><K><C><K><E><T><P><Y><S><E><E><D><F><Q><H><L><Q><K><E><I><E><Q><L><Q><E><K><Y><K><T><E><L><C><T><K><Q><A><L><L><A><E><L><E><E><Q><K><I><V><Q><A><K><L><K><Q><T><L><T><F><F><D><E><L><H><N><V><G><R><D><H><G><T><S><D><F><R><E><S><L><V><S><L><V><Q><N><S><R><K><L><Q><N><I><R><D><N><V><E><K><E><S><K><R><L><K><I><S>
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis . Essential for proper kinetochore microtubule attachments .<BOP>
Q9H081
Q8N8Q8
COX18_HUMAN
Cytochrome c oxidase assembly protein 18
Homo
<M><L><C><R><L><G><G><R><W><L><R><P><L><P><A><L><Q><L><W><A><R><D><L><P><L><A><P><V><P><T><S><G><A><K><R><P><T><L><P><V><W><A><V><A><P><V><S><A><V><H><A><N><G><W><Y><E><A><L><A><A><S><S><P><V><R><V><A><E><E><V><L><L><G><V><H><A><A><T><G><L><P><W><W><G><S><I><L><L><S><T><V><A><L><R><G><A><V><T><L><P><L><A><A><Y><Q><H><Y><I><L><A><K><V><E><N><L><Q><P><E><I><K><T><I><A><R><H><L><N><Q><E><V><A><V><R><A><N><Q><L><G><W><S><K><R><D><A><R><L><T><Y><L><K><N><M><R><R><L><I><S><E><L><Y><V><R><D><N><C><H><P><F><K><A><T><V><L><V><W><I><Q><L><P><M><W><I><F><M><S><F><A><L><R><N><L><S><T><G><A><A><H><S><E><G><F><S><V><Q><E><Q><L><A><T><G><G><I><L><W><F><P><D><L><T><A><P><D><S><T><W><I><L><P><I><S><V><G><V><I><N><L><L><I><V><E><I><C><A><L><Q><K><I><G><M><S><R><F><Q><T><Y><I><T><Y><F><V><R><A><M><S><V><L><M><I><P><I><A><A><T><V><P><S><S><I><V><L><Y><W><L><C><S><S><F><V><G><L><S><Q><N><L><L><L><R><S><P><G><F><R><Q><L><C><R><I><P><S><T><K><S><D><S><E><T><P><Y><K><D><I><F><A><A><F><N><T><K><F><I><S><R><K>
Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase).<BOP>
Q8N8Q8
O14763
TR10B_HUMAN
TNF-related apoptosis-inducing ligand receptor 2
Homo
<M><E><Q><R><G><Q><N><A><P><A><A><S><G><A><R><K><R><H><G><P><G><P><R><E><A><R><G><A><R><P><G><P><R><V><P><K><T><L><V><L><V><V><A><A><V><L><L><L><V><S><A><E><S><A><L><I><T><Q><Q><D><L><A><P><Q><Q><R><A><A><P><Q><Q><K><R><S><S><P><S><E><G><L><C><P><P><G><H><H><I><S><E><D><G><R><D><C><I><S><C><K><Y><G><Q><D><Y><S><T><H><W><N><D><L><L><F><C><L><R><C><T><R><C><D><S><G><E><V><E><L><S><P><C><T><T><T><R><N><T><V><C><Q><C><E><E><G><T><F><R><E><E><D><S><P><E><M><C><R><K><C><R><T><G><C><P><R><G><M><V><K><V><G><D><C><T><P><W><S><D><I><E><C><V><H><K><E><S><G><T><K><H><S><G><E><V><P><A><V><E><E><T><V><T><S><S><P><G><T><P><A><S><P><C><S><L><S><G><I><I><I><G><V><T><V><A><A><V><V><L><I><V><A><V><F><V><C><K><S><L><L><W><K><K><V><L><P><Y><L><K><G><I><C><S><G><G><G><G><D><P><E><R><V><D><R><S><S><Q><R><P><G><A><E><D><N><V><L><N><E><I><V><S><I><L><Q><P><T><Q><V><P><E><Q><E><M><E><V><Q><E><P><A><E><P><T><G><V><N><M><L><S><P><G><E><S><E><H><L><L><E><P><A><E><A><E><R><S><Q><R><R><R><L><L><V><P><A><N><E><G><D><P><T><E><T><L><R><Q><C><F><D><D><F><A><D><L><V><P><F><D><S><W><E><P><L><M><R><K><L><G><L><M><D><N><E><I><K><V><A><K><A><E><A><A><G><H><R><D><T><L><Y><T><M><L><I><K><W><V><N><K><T><G><R><D><A><S><V><H><T><L><L><D><A><L><E><T><L><G><E><R><L><A><K><Q><K><I><E><D><H><L><L><S><S><G><K><F><M><Y><L><E><G><N><A><D><S><A><M><S>
Receptor for the cytotoxic ligand TNFSF10/TRAIL . The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.<BOP>
O14763
O00501
CLD5_HUMAN
Transmembrane protein deleted in VCFS
Homo
<M><G><S><A><A><L><E><I><L><G><L><V><L><C><L><V><G><W><G><G><L><I><L><A><C><G><L><P><M><W><Q><V><T><A><F><L><D><H><N><I><V><T><A><Q><T><T><W><K><G><L><W><M><S><C><V><V><Q><S><T><G><H><M><Q><C><K><V><Y><D><S><V><L><A><L><S><T><E><V><Q><A><A><R><A><L><T><V><S><A><V><L><L><A><F><V><A><L><F><V><T><L><A><G><A><Q><C><T><T><C><V><A><P><G><P><A><K><A><R><V><A><L><T><G><G><V><L><Y><L><F><C><G><L><L><A><L><V><P><L><C><W><F><A><N><I><V><V><R><E><F><Y><D><P><S><V><P><V><S><Q><K><Y><E><L><G><A><A><L><Y><I><G><W><A><A><T><A><L><L><M><V><G><G><C><L><L><C><C><G><A><W><V><C><T><G><R><P><D><L><S><F><P><V><K><Y><S><A><P><R><R><P><T><A><T><G><D><Y><D><K><K><N><Y><V>
Plays a major role in tight junction-specific obliteration of the intercellular space.<BOP>
O00501
Q96EF6
FBX17_HUMAN
F-box only protein 26
Homo
<M><G><A><R><L><S><R><R><R><L><P><A><D><P><S><L><A><L><D><A><L><P><P><E><L><L><V><Q><V><L><S><H><V><P><P><R><S><L><V><T><R><C><R><P><V><C><R><A><W><R><D><I><V><D><G><P><T><V><W><L><L><Q><L><A><R><D><R><S><A><E><G><R><A><L><Y><A><V><A><Q><R><C><L><P><S><N><E><D><K><E><E><F><P><L><C><A><L><A><R><Y><C><L><R><A><P><F><G><R><N><L><I><F><N><S><C><G><E><Q><G><F><R><G><W><E><V><E><H><G><G><N><G><W><A><I><E><K><N><L><T><P><V><P><G><A><P><S><Q><T><C><F><V><T><S><F><E><W><C><S><K><R><Q><L><V><D><L><V><M><E><G><V><W><Q><E><L><L><D><S><A><Q><I><E><I><C><V><A><D><W><W><G><A><R><E><N><C><G><C><V><Y><Q><L><R><V><R><L><L><D><V><Y><E><K><E><V><V><K><F><S><A><S><P><D><P><V><L><Q><W><T><E><R><G><C><R><Q><V><S><H><V><F><T><N><F><G><K><G><I><R><Y><V><S><F><E><Q><Y><G><R><D><V><S><S><W><V><G><H><Y><G><A><L><V><T><H><S><S><V><R><V><R><I><R><L><S>
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.<BOP>
Q96EF6
Q9H1K6
TLRN1_HUMAN
Mesoderm development candidate 1
Homo
<M><A><S><G><S><A><G><K><P><T><G><E><A><A><S><P><A><P><A><S><A><I><G><G><A><S><S><Q><P><R><K><R><L><V><S><V><C><D><H><C><K><G><K><M><Q><L><V><A><D><L><L><L><L><S><S><E><A><R><P><V><L><F><E><G><P><A><S><S><G><A><G><A><E><S><F><E><Q><C><R><D><T><I><I><A><R><T><K><G><L><S><I><L><T><H><D><V><Q><S><Q><L><N><M><G><R><F><G><E><A><G><D><S><L><V><E><L><G><D><L><V><V><S><L><T><E><C><S><A><H><A><A><Y><L><A><A><V><A><T><P><G><A><Q><P><A><Q><P><G><L><V><D><R><Y><R><V><T><R><C><R><H><E><V><E><Q><G><C><A><V><L><R><A><T><P><L><A><D><M><T><P><Q><L><L><L><E><V><S><Q><G><L><S><R><N><L><K><F><L><T><D><A><C><A><L><A><S><D><K><S><R><D><R><F><S><R><E><Q><F><K><L><G><V><K><C><M><S><T><S><A><S><A><L><L><A><C><V><R><E><V><K><V><A><P><S><E><L><A><R><S><R><C><A><L><F><S><G><P><L><V><Q><A><V><S><A><L><V><G><F><A><T><E><P><Q><F><L><G><R><A><A><A><V><S><A><E><G><K><A><V><Q><T><A><I><L><G><G><A><M><S><V><V><S><A><C><V><L><L><T><Q><C><L><R><D><L><A><Q><H><P><D><G><G><A><K><M><S><D><H><R><E><R><L><R><N><S><A><C><A><V><S><E><G><C><T><L><L><S><Q><A><L><R><E><R><S><S><P><R><T><L><P><P><V><N><S><N><S><V><N>
Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.<BOP>
Q9H1K6
Q9Y585
OR1A2_HUMAN
Olfactory receptor OR17-10
Homo
<M><K><K><E><N><Q><S><F><N><L><D><F><I><L><L><G><V><T><S><Q><Q><E><Q><N><N><V><F><F><V><I><F><L><C><I><Y><P><I><T><L><T><G><N><L><L><I><I><L><A><I><C><A><D><I><R><L><H><N><P><M><Y><F><L><L><A><N><L><S><L><V><D><I><I><F><S><S><V><T><I><P><K><V><L><A><N><H><L><L><G><S><K><F><I><S><F><G><G><C><L><M><Q><M><Y><F><M><I><A><L><A><K><A><D><S><Y><T><L><A><A><M><A><Y><D><R><A><V><A><I><S><C><P><L><H><Y><T><T><I><M><S><P><R><S><C><I><L><L><I><A><G><S><W><V><I><G><N><T><S><A><L><P><H><T><L><L><T><A><S><L><S><F><C><G><N><Q><E><V><A><N><F><Y><C><D><I><M><P><L><L><K><L><S><C><S><D><V><H><F><N><V><K><M><M><Y><L><G><V><G><V><F><S><L><P><L><L><C><I><I><V><S><Y><V><Q><V><F><S><T><V><F><Q><V><P><S><T><K><S><L><F><K><A><F><C><T><C><G><S><H><L><T><V><V><F><L><Y><Y><G><T><T><M><G><M><Y><F><R><P><L><T><S><Y><S><P><K><D><A><V><I><T><V><M><Y><V><A><V><T><P><A><L><N><P><F><I><Y><S><L><R><N><W><D><M><K><A><A><L><Q><K><L><F><S><K><R><I><S><S>
Odorant receptor.<BOP>
Q9Y585
Q14CN4
K2C72_HUMAN
Type-II keratin Kb35
Homo
<M><S><R><Q><L><T><H><F><P><R><G><E><R><L><G><F><S><G><C><S><A><V><L><S><G><G><I><G><S><S><S><A><S><F><R><A><R><V><K><G><S><A><S><F><G><S><K><S><L><S><C><L><G><G><S><R><S><L><A><L><S><A><A><A><R><R><G><G><G><R><L><G><G><F><V><G><T><A><F><G><S><A><G><L><G><P><K><C><P><S><V><C><P><P><G><G><I><P><Q><V><T><V><N><K><S><L><L><A><P><L><N><V><E><M><D><P><E><I><Q><R><V><R><A><Q><E><R><E><Q><I><K><A><L><N><N><K><F><A><S><F><I><D><K><V><R><F><L><E><Q><Q><N><Q><V><L><E><T><K><W><N><L><L><Q><Q><L><D><L><N><N><C><R><K><N><L><E><P><I><Y><E><G><Y><I><S><N><L><Q><K><Q><L><E><M><L><S><G><D><G><V><R><L><D><S><E><L><R><N><M><Q><D><L><V><E><D><Y><K><K><R><Y><E><V><E><I><N><R><R><T><A><A><E><N><E><F><V><V><L><K><K><D><V><D><A><A><Y><M><N><K><V><E><L><Q><A><K><V><D><S><L><T><D><E><I><K><F><F><K><C><L><Y><E><G><E><I><T><Q><I><Q><S><H><I><S><D><T><S><I><V><L><S><M><D><N><N><R><D><L><D><L><D><S><I><I><A><E><V><R><A><Q><Y><E><E><I><A><L><K><S><K><A><E><A><E><T><L><Y><Q><T><K><I><Q><E><L><Q><V><T><A><G><Q><H><G><D><D><L><K><L><T><K><A><E><I><S><E><L><N><R><L><I><Q><R><I><R><S><E><I><G><N><V><K><K><Q><C><A><D><L><E><T><A><I><A><D><A><E><Q><R><G><D><C><A><L><K><D><A><R><A><K><L><D><E><L><E><G><A><L><H><Q><A><K><E><E><L><A><R><M><L><R><E><Y><Q><E><L><V><S><L><K><L><A><L><D><M><E><I><A><T><Y><R><K><L><L><E><S><E><E><C><R><M><S><G><E><Y><P><N><S><V><S><I><S><V><I><S><S><T><N><A><G><A><G><G><A><G><F><S><M><G><F><G><A><S><S><S><Y><S><Y><K><T><A><A><A><D><V><K><T><K><G><S><C><G><S><E><L><K><D><P><L><A><K><T><S><G><S><S><C><A><T><K><K><A><S><R>
Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).<BOP>
Q14CN4
O76061
STC2_HUMAN
Stanniocalcin-related protein
Homo
<M><C><A><E><R><L><G><Q><F><M><T><L><A><L><V><L><A><T><F><D><P><A><R><G><T><D><A><T><N><P><P><E><G><P><Q><D><R><S><S><Q><Q><K><G><R><L><S><L><Q><N><T><A><E><I><Q><H><C><L><V><N><A><G><D><V><G><C><G><V><F><E><C><F><E><N><N><S><C><E><I><R><G><L><H><G><I><C><M><T><F><L><H><N><A><G><K><F><D><A><Q><G><K><S><F><I><K><D><A><L><K><C><K><A><H><A><L><R><H><R><F><G><C><I><S><R><K><C><P><A><I><R><E><M><V><S><Q><L><Q><R><E><C><Y><L><K><H><D><L><C><A><A><A><Q><E><N><T><R><V><I><V><E><M><I><H><F><K><D><L><L><L><H><E><P><Y><V><D><L><V><N><L><L><L><T><C><G><E><E><V><K><E><A><I><T><H><S><V><Q><V><Q><C><E><Q><N><W><G><S><L><C><S><I><L><S><F><C><T><S><A><I><Q><K><P><P><T><A><P><P><E><R><Q><P><Q><V><D><R><T><K><L><S><R><A><H><H><G><E><A><G><H><H><L><P><E><P><S><S><R><E><T><G><R><G><A><K><G><E><R><G><S><K><S><H><P><N><A><H><A><R><G><R><V><G><G><L><G><A><Q><G><P><S><G><S><S><E><W><E><D><E><Q><S><E><Y><S><D><I><R><R>
Has an anti-hypocalcemic action on calcium and phosphate homeostasis.<BOP>
O76061
Q96DN0
ERP27_HUMAN
Inactive protein disulfide-isomerase 27
Homo
<M><E><A><A><P><S><R><F><M><F><L><L><F><L><L><T><C><E><L><A><A><E><V><A><A><E><V><E><K><S><S><D><G><P><G><A><A><Q><E><P><T><W><L><T><D><V><P><A><A><M><E><F><I><A><A><T><E><V><A><V><I><G><F><F><Q><D><L><E><I><P><A><V><P><I><L><H><S><M><V><Q><K><F><P><G><V><S><F><G><I><S><T><D><S><E><V><L><T><H><Y><N><I><T><G><N><T><I><C><L><F><R><L><V><D><N><E><Q><L><N><L><E><D><E><D><I><E><S><I><D><A><T><K><L><S><R><F><I><E><I><N><S><L><H><M><V><T><E><Y><N><P><V><T><V><I><G><L><F><N><S><V><I><Q><I><H><L><L><L><I><M><N><K><A><S><P><E><Y><E><E><N><M><H><R><Y><Q><K><A><A><K><L><F><Q><G><K><I><L><F><I><L><V><D><S><G><M><K><E><N><G><K><V><I><S><F><F><K><L><K><E><S><Q><L><P><A><L><A><I><Y><Q><T><L><D><D><E><W><D><T><L><P><T><A><E><V><S><V><E><H><V><Q><N><F><C><D><G><F><L><S><G><K><L><L><K><E><N><R><E><S><E><G><K><T><P><K><V><E><L>
Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates . Binds protein substrates via a hydrophobic pocket in the C-terminal domain . May play a role in the unfolded stress response .<BOP>
Q96DN0
Q99677
LPAR4_HUMAN
Purinergic receptor 9
Homo
<M><G><D><R><R><F><I><D><F><Q><F><Q><D><S><N><S><S><L><R><P><R><L><G><N><A><T><A><N><N><T><C><I><V><D><D><S><F><K><Y><N><L><N><G><A><V><Y><S><V><V><F><I><L><G><L><I><T><N><S><V><S><L><F><V><F><C><F><R><M><K><M><R><S><E><T><A><I><F><I><T><N><L><A><V><S><D><L><L><F><V><C><T><L><P><F><K><I><F><Y><N><F><N><R><H><W><P><F><G><D><T><L><C><K><I><S><G><T><A><F><L><T><N><I><Y><G><S><M><L><F><L><T><C><I><S><V><D><R><F><L><A><I><V><Y><P><F><R><S><R><T><I><R><T><R><R><N><S><A><I><V><C><A><G><V><W><I><L><V><L><S><G><G><I><S><A><S><L><F><S><T><T><N><V><N><N><A><T><T><T><C><F><E><G><F><S><K><R><V><W><K><T><Y><L><S><K><I><T><I><F><I><E><V><V><G><F><I><I><P><L><I><L><N><V><S><C><S><S><V><V><L><R><T><L><R><K><P><A><T><L><S><Q><I><G><T><N><K><K><K><V><L><K><M><I><T><V><H><M><A><V><F><V><V><C><F><V><P><Y><N><S><V><L><F><L><Y><A><L><V><R><S><Q><A><I><T><N><C><F><L><E><R><F><A><K><I><M><Y><P><I><T><L><C><L><A><T><L><N><C><C><F><D><P><F><I><Y><Y><F><T><L><E><S><F><Q><K><S><F><Y><I><N><A><H><I><R><M><E><S><L><F><K><T><E><T><P><L><T><T><K><P><S><L><P><A><I><Q><E><E><V><S><D><Q><T><T><N><N><G><G><E><L><M><L><E><S><T><F>
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.<BOP>
Q99677
Q96F85
CNRP1_HUMAN
CB1 cannabinoid receptor-interacting protein 1
Homo
<M><G><D><L><P><G><L><V><R><L><S><I><A><L><R><I><Q><P><N><D><G><P><V><F><Y><K><V><D><G><Q><R><F><G><Q><N><R><T><I><K><L><L><T><G><S><S><Y><K><V><E><V><K><I><K><P><S><T><L><Q><V><E><N><I><S><I><G><G><V><L><V><P><L><E><L><K><S><K><E><P><D><G><D><R><V><V><Y><T><G><T><Y><D><T><E><G><V><T><P><T><K><S><G><E><R><Q><P><I><Q><I><T><M><P><F><T><D><I><G><T><F><E><T><V><W><Q><V><K><F><Y><N><Y><H><K><R><D><H><C><Q><W><G><S><P><F><S><V><I><E><Y><E><C><K><P><N><E><T><R><S><L><M><W><V><N><K><E><S><F><L>
Does not suppress cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.<BOP>
Q96F85
O60739
EIF1B_HUMAN
Protein translation factor SUI1 homolog GC20
Homo
<M><S><T><I><Q><N><L><Q><S><F><D><P><F><A><D><A><T><K><G><D><D><L><L><P><A><G><T><E><D><Y><I><H><I><R><I><Q><Q><R><N><G><R><K><T><L><T><T><V><Q><G><I><A><D><D><Y><D><K><K><K><L><V><K><A><F><K><K><K><F><A><C><N><G><T><V><I><E><H><P><E><Y><G><E><V><I><Q><L><Q><G><D><Q><R><K><N><I><C><Q><F><L><L><E><V><G><I><V><K><E><E><Q><L><K><V><H><G><F>
Probably involved in translation.<BOP>
O60739
Q15124
PGM5_HUMAN
Phosphoglucomutase-related protein
Homo
<M><E><G><S><P><I><P><V><L><T><V><P><T><A><P><Y><E><D><Q><R><P><A><G><G><G><G><L><R><R><P><T><G><L><F><E><G><Q><R><N><Y><L><P><N><F><I><Q><S><V><L><S><S><I><D><L><R><D><R><Q><G><C><T><M><V><V><G><S><D><G><R><Y><F><S><R><T><A><I><E><I><V><V><Q><M><A><A><A><N><G><I><G><R><L><I><I><G><Q><N><G><I><L><S><T><P><A><V><S><C><I><I><R><K><I><K><A><A><G><G><I><I><L><T><A><S><H><C><P><G><G><P><G><G><E><F><G><V><K><F><N><V><A><N><G><G><P><A><P><D><V><V><S><D><K><I><Y><Q><I><S><K><T><I><E><E><Y><A><I><C><P><D><L><R><I><D><L><S><R><L><G><R><Q><E><F><D><L><E><N><K><F><K><P><F><R><V><E><I><V><D><P><V><D><I><Y><L><N><L><L><R><T><I><F><D><F><H><A><I><K><G><L><L><T><G><P><S><Q><L><K><I><R><I><D><A><M><H><G><V><M><G><P><Y><V><R><K><V><L><C><D><E><L><G><A><P><A><N><S><A><I><N><C><V><P><L><E><D><F><G><G><Q><H><P><D><P><N><L><T><Y><A><T><T><L><L><E><A><M><K><G><G><E><Y><G><F><G><A><A><F><D><A><D><G><D><R><Y><M><I><L><G><Q><N><G><F><F><V><S><P><S><D><S><L><A><I><I><A><A><N><L><S><C><I><P><Y><F><R><Q><M><G><V><R><G><F><G><R><S><M><P><T><S><M><A><L><D><R><V><A><K><S><M><K><V><P><V><Y><E><T><P><A><G><W><R><F><F><S><N><L><M><D><S><G><R><C><N><L><C><G><E><E><S><F><G><T><G><S><D><H><L><R><E><K><D><G><L><W><A><V><L><V><W><L><S><I><I><A><A><R><K><Q><S><V><E><E><I><V><R><D><H><W><A><K><F><G><R><H><Y><Y><C><R><F><D><Y><E><G><L><D><P><K><T><T><Y><Y><I><M><R><D><L><E><A><L><V><T><D><K><S><F><I><G><Q><Q><F><A><V><G><S><H><V><Y><S><V><A><K><T><D><S><F><E><Y><V><D><P><V><D><G><T><V><T><K><K><Q><G><L><R><I><I><F><S><D><A><S><R><L><I><F><R><L><S><S><S><S><G><V><R><A><T><L><R><L><Y><A><E><S><Y><E><R><D><P><S><G><H><D><Q><E><P><Q><A><V><L><S><P><L><I><A><I><A><L><K><I><S><Q><I><H><E><R><T><G><R><R><G><P><T><V><I><T>
Component of adherens-type cell-cell and cell-matrix junctions . Has no phosphoglucomutase activity in vitro .<BOP>
Q15124
Q9BTV7
CABL2_HUMAN
Interactor with CDK3 2
Homo
<M><A><A><A><A><A><G><G><A><P><G><P><A><P><G><P><A><G><P><P><P><P><A><A><P><T><S><A><A><R><A><P><P><Q><A><L><R><R><R><G><D><S><R><R><R><Q><A><A><L><F><F><L><N><N><I><S><L><D><G><R><P><P><S><L><G><P><G><G><E><K><P><P><P><P><P><A><E><A><R><E><P><P><A><P><P><P><P><E><P><P><T><G><L><P><A><R><T><P><A><P><Q><G><L><L><S><P><T><Q><V><P><T><G><L><G><L><D><G><Q><R><Q><R><K><R><V><T><S><Q><R><C><S><L><E><F><L><E><D><A><V><G><C><A><P><A><Q><R><T><K><H><T><S><G><S><P><R><H><K><G><L><K><K><T><H><F><I><K><N><M><R><Q><Y><D><T><R><N><S><R><I><V><L><I><C><A><K><R><S><L><C><A><A><F><S><V><L><P><Y><G><E><G><L><R><I><S><D><L><R><V><D><S><Q><K><Q><R><H><P><S><G><G><V><S><V><S><S><E><M><V><F><E><L><E><G><V><E><L><G><A><D><G><K><V><V><S><Y><A><K><F><L><Y><P><T><N><A><L><V><T><H><K><S><D><S><H><G><L><L><P><T><P><R><P><S><V><P><R><T><L><P><G><S><R><H><K><P><A><P><T><K><S><A><P><A><S><T><E><L><G><S><D><V><G><D><T><L><E><Y><N><P><N><L><L><D><D><P><Q><W><P><C><G><K><H><K><R><V><L><I><F><A><S><Y><M><T><T><V><I><E><Y><V><K><P><S><D><L><K><K><D><M><N><E><T><F><R><E><K><F><P><H><V><K><L><T><L><S><K><I><R><S><L><K><R><E><M><R><S><L><S><E><E><C><S><L><E><P><V><T><V><A><M><A><Y><V><Y><F><E><K><L><V><L><Q><G><K><L><S><K><Q><N><R><K><L><C><A><G><A><C><V><L><L><A><A><K><I><S><S><D><L><R><K><S><G><V><T><Q><L><I><D><K><L><E><E><R><F><R><F><N><R><R><D><L><I><G><F><E><F><T><V><L><V><A><L><E><L><A><L><Y><L><P><E><N><Q><V><L><P><H><Y><R><R><L><T><Q><Q><F>
Unknown. Probably involved in G1-S cell cycle transition.<BOP>
Q9BTV7
Q9Y5Y0
FLVC1_HUMAN
Feline leukemia virus subgroup C receptor-related protein 1
Homo
<M><A><R><P><D><D><E><E><G><A><A><V><A><P><G><H><P><L><A><K><G><Y><L><P><L><P><R><G><A><P><V><G><K><E><S><V><E><L><Q><N><G><P><K><A><G><T><F><P><V><N><G><A><P><R><D><S><L><A><A><A><S><G><V><L><G><G><P><Q><T><P><L><A><P><E><E><E><T><Q><A><R><L><L><P><A><G><A><G><A><E><T><P><G><A><E><S><S><P><L><P><L><T><A><L><S><P><R><R><F><V><V><L><L><I><F><S><L><Y><S><L><V><N><A><F><Q><W><I><Q><Y><S><I><I><S><N><V><F><E><G><F><Y><G><V><T><L><L><H><I><D><W><L><S><M><V><Y><M><L><A><Y><V><P><L><I><F><P><A><T><W><L><L><D><T><R><G><L><R><L><T><A><L><L><G><S><G><L><N><C><L><G><A><W><I><K><C><G><S><V><Q><Q><H><L><F><W><V><T><M><L><G><Q><C><L><C><S><V><A><Q><V><F><I><L><G><L><P><S><R><I><A><S><V><W><F><G><P><K><E><V><S><T><A><C><A><T><A><V><L><G><N><Q><L><G><T><A><V><G><F><L><L><P><P><V><L><V><P><N><T><Q><N><D><T><N><L><L><A><C><N><I><S><T><M><F><Y><G><T><S><A><V><A><T><L><L><F><I><L><T><A><I><A><F><K><E><K><P><R><Y><P><P><S><Q><A><Q><A><A><L><Q><D><S><P><P><E><E><Y><S><Y><K><K><S><I><R><N><L><F><K><N><I><P><F><V><L><L><L><I><T><Y><G><I><M><T><G><A><F><Y><S><V><S><T><L><L><N><Q><M><I><L><T><Y><Y><E><G><E><E><V><N><A><G><R><I><G><L><T><L><V><V><A><G><M><V><G><S><I><L><C><G><L><W><L><D><Y><T><K><T><Y><K><Q><T><T><L><I><V><Y><I><L><S><F><I><G><M><V><I><F><T><F><T><L><D><L><R><Y><I><I><I><V><F><V><T><G><G><V><L><G><F><F><M><T><G><Y><L><P><L><G><F><E><F><A><V><E><I><T><Y><P><E><S><E><G><T><S><S><G><L><L><N><A><S><A><Q><I><F><G><I><L><F><T><L><A><Q><G><K><L><T><S><D><Y><G><P><K><A><G><N><I><F><L><C><V><W><M><F><I><G><I><I><L><T><A><L><I><K><S><D><L><R><R><H><N><I><N><I><G><I><T><N><V><D><V><K><A><I><P><A><D><S><P><T><D><Q><E><P><K><T><V><M><L><S><K><Q><S><E><S><A><I>
Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation.<BOP>
Q9Y5Y0
O15228
GNPAT_HUMAN
Glycerone-phosphate O-acyltransferase
Homo
<M><E><S><S><S><S><S><N><S><Y><F><S><V><G><P><T><S><P><S><A><V><V><L><L><Y><S><K><E><L><K><K><W><D><E><F><E><D><I><L><E><E><R><R><H><V><S><D><L><K><F><A><M><K><C><Y><T><P><L><V><Y><K><G><I><T><P><C><K><P><I><D><I><K><C><S><V><L><N><S><E><E><I><H><Y><V><I><K><Q><L><S><K><E><S><L><Q><S><V><D><V><L><R><E><E><V><S><E><I><L><D><E><M><S><H><K><L><R><L><G><A><I><R><F><C><A><F><T><L><S><K><V><F><K><Q><I><F><S><K><V><C><V><N><E><E><G><I><Q><K><L><Q><R><A><I><Q><E><H><P><V><V><L><L><P><S><H><R><S><Y><I><D><F><L><M><L><S><F><L><L><Y><N><Y><D><L><P><V><P><V><I><A><A><G><M><D><F><L><G><M><K><M><V><G><E><L><L><R><M><S><G><A><F><F><M><R><R><T><F><G><G><N><K><L><Y><W><A><V><F><S><E><Y><V><K><T><M><L><R><N><G><Y><A><P><V><E><F><F><L><E><G><T><R><S><R><S><A><K><T><L><T><P><K><F><G><L><L><N><I><V><M><E><P><F><F><K><R><E><V><F><D><T><Y><L><V><P><I><S><I><S><Y><D><K><I><L><E><E><T><L><Y><V><Y><E><L><L><G><V><P><K><P><K><E><S><T><T><G><L><L><K><A><R><K><I><L><S><E><N><F><G><S><I><H><V><Y><F><G><D><P><V><S><L><R><S><L><A><A><G><R><M><S><R><S><S><Y><N><L><V><P><R><Y><I><P><Q><K><Q><S><E><D><M><H><A><F><V><T><E><V><A><Y><K><M><E><L><L><Q><I><E><N><M><V><L><S><P><W><T><L><I><V><A><V><L><L><Q><N><R><P><S><M><D><F><D><A><L><V><E><K><T><L><W><L><K><G><L><T><Q><A><F><G><G><F><L><I><W><P><D><N><K><P><A><E><E><V><V><P><A><S><I><L><L><H><S><N><I><A><S><L><V><K><D><Q><V><I><L><K><V><D><S><G><D><S><E><V><V><D><G><L><M><L><Q><H><I><T><L><L><M><C><S><A><Y><R><N><Q><L><L><N><I><F><V><R><P><S><L><V><A><V><A><L><Q><M><T><P><G><F><R><K><E><D><V><Y><S><C><F><R><F><L><R><D><V><F><A><D><E><F><I><F><L><P><G><N><T><L><K><D><F><E><E><G><C><Y><L><L><C><K><S><E><A><I><Q><V><T><T><K><D><I><L><V><T><E><K><G><N><T><V><L><E><F><L><V><G><L><F><K><P><F><V><E><S><Y><Q><I><I><C><K><Y><L><L><S><E><E><E><D><H><F><S><E><E><Q><Y><L><A><A><V><R><K><F><T><S><Q><L><L><D><Q><G><T><S><Q><C><Y><D><V><L><S><S><D><V><Q><K><N><A><L><A><A><C><V><R><L><G><V><V><E><K><K><K><I><N><N><N><C><I><F><N><V><N><E><P><A><T><T><K><L><E><E><M><L><G><C><K><T><P><I><G><K><P><A><T><A><K><L>
Dihydroxyacetonephosphate acyltransferase involved in plasmalogen biosynthesis.<BOP>
O15228
Q8WXG1
RSAD2_HUMAN
Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Homo
<M><W><V><L><T><P><A><A><F><A><G><K><L><L><S><V><F><R><Q><P><L><S><S><L><W><R><S><L><V><P><L><F><C><W><L><R><A><T><F><W><L><L><A><T><K><R><R><K><Q><Q><L><V><L><R><G><P><D><E><T><K><E><E><E><E><D><P><P><L><P><T><T><P><T><S><V><N><Y><H><F><T><R><Q><C><N><Y><K><C><G><F><C><F><H><T><A><K><T><S><F><V><L><P><L><E><E><A><K><R><G><L><L><L><L><K><E><A><G><M><E><K><I><N><F><S><G><G><E><P><F><L><Q><D><R><G><E><Y><L><G><K><L><V><R><F><C><K><V><E><L><R><L><P><S><V><S><I><V><S><N><G><S><L><I><R><E><R><W><F><Q><N><Y><G><E><Y><L><D><I><L><A><I><S><C><D><S><F><D><E><E><V><N><V><L><I><G><R><G><Q><G><K><K><N><H><V><E><N><L><Q><K><L><R><R><W><C><R><D><Y><R><V><A><F><K><I><N><S><V><I><N><R><F><N><V><E><E><D><M><T><E><Q><I><K><A><L><N><P><V><R><W><K><V><F><Q><C><L><L><I><E><G><E><N><C><G><E><D><A><L><R><E><A><E><R><F><V><I><G><D><E><E><F><E><R><F><L><E><R><H><K><E><V><S><C><L><V><P><E><S><N><Q><K><M><K><D><S><Y><L><I><L><D><E><Y><M><R><F><L><N><C><R><K><G><R><K><D><P><S><K><S><I><L><D><V><G><V><E><E><A><I><K><F><S><G><F><D><E><K><M><F><L><K><R><G><G><K><Y><I><W><S><K><A><D><L><K><L><D><W>
Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon . Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism . In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication . Therefore, inhibits a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), zika virus, and human immunodeficiency virus (HIV-1) . Promotes also TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6 . Plays a role in CD4+ T-cells activation and differentiation.
Q8WXG1
Q9NUV7
SPTC3_HUMAN
Serine-palmitoyl-CoA transferase 3
Homo
<M><A><N><P><G><G><G><A><V><C><N><G><K><L><H><N><H><K><K><Q><S><N><G><S><Q><S><R><N><C><T><K><N><G><I><V><K><E><A><Q><Q><N><G><K><P><H><F><Y><D><K><L><I><V><E><S><F><E><E><A><P><L><H><V><M><V><F><T><Y><M><G><Y><G><I><G><T><L><F><G><Y><L><R><D><F><L><R><N><W><G><I><E><K><C><N><A><A><V><E><R><K><E><Q><K><D><F><V><P><L><Y><Q><D><F><E><N><F><Y><T><R><N><L><Y><M><R><I><R><D><N><W><N><R><P><I><C><S><A><P><G><P><L><F><D><L><M><E><R><V><S><D><D><Y><N><W><T><F><R><F><T><G><R><V><I><K><D><V><I><N><M><G><S><Y><N><F><L><G><L><A><A><K><Y><D><E><S><M><R><T><I><K><D><V><L><E><V><Y><G><T><G><V><A><S><T><R><H><E><M><G><T><L><D><K><H><K><E><L><E><D><L><V><A><K><F><L><N><V><E><A><A><M><V><F><G><M><G><F><A><T><N><S><M><N><I><P><A><L><V><G><K><G><C><L><I><L><S><D><E><L><N><H><T><S><L><V><L><G><A><R><L><S><G><A><T><I><R><I><F><K><H><N><N><T><Q><S><L><E><K><L><L><R><D><A><V><I><Y><G><Q><P><R><T><R><R><A><W><K><K><I><L><I><L><V><E><G><V><Y><S><M><E><G><S><I><V><H><L><P><Q><I><I><A><L><K><K><K><Y><K><A><Y><L><Y><I><D><E><A><H><S><I><G><A><V><G><P><T><G><R><G><V><T><E><F><F><G><L><D><P><H><E><V><D><V><L><M><G><T><F><T><K><S><F><G><A><S><G><G><Y><I><A><G><R><K><D><L><V><D><Y><L><R><V><H><S><H><S><A><V><Y><A><S><S><M><S><P><P><I><A><E><Q><I><I><R><S><L><K><L><I><M><G><L><D><G><T><T><Q><G><L><Q><R><V><Q><Q><L><A><K><N><T><R><Y><F><R><Q><R><L><Q><E><M><G><F><I><I><Y><G><N><E><N><A><S><V><V><P><L><L><L><Y><M><P><G><K><V><A><A><F><A><R><H><M><L><E><K><K><I><G><V><V><V><V><G><F><P><A><T><P><L><A><E><A><R><A><R><F><C><V><S><A><A><H><T><R><E><M><L><D><T><V><L><E><A><L><D><E><M><G><D><L><L><Q><L><K><Y><S><R><H><K><K><S><A><R><P><E><L><Y><D><E><T><S><F><E><L><E><D>
Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. SPT complexes containing SPTLC3 generate shorter chain sphingoid bases compared to complexes containing SPTLC2. The SPTLC1-SPTLC3-SPTSSA isozyme uses C12-CoA, C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. On the other hand, the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference.<BOP>
Q9NUV7
Q155Q3
DIXC1_HUMAN
DIX domain-containing protein 1
Homo
<M><L><A><C><L><T><R><G><N><L><L><D><V><L><Q><E><G><F><N><E><Q><Q><L><Q><A><Y><V><A><W><V><N><A><Q><L><K><K><R><P><A><V><K><P><V><Q><D><L><R><Q><D><L><R><D><G><V><I><L><A><Y><L><I><E><I><V><A><G><E><K><L><S><G><V><Q><L><S><P><G><N><Q><Q><E><M><K><N><N><V><E><K><V><L><Q><F><V><A><S><K><K><I><R><M><H><Q><T><S><A><K><D><I><V><D><G><N><L><K><S><I><M><R><L><V><L><A><L><A><A><H><F><K><P><G><S><S><R><T><V><N><Q><G><R><D><S><R><A><P><L><Q><S><H><R><P><H><C><A><T><A><V><A><Q><G><A><A><A><A><L><A><D><V><C><H><D><M><S><R><S><G><R><D><V><F><R><Y><R><Q><R><N><S><S><M><D><E><E><I><E><N><P><Y><W><S><V><R><A><L><V><Q><Q><Y><E><G><Q><Q><R><S><P><S><E><S><S><C><S><S><L><T><S><P><S><P><I><H><S><A><K><S><E><S><I><I><T><Q><S><E><E><K><A><D><F><V><I><I><P><A><E><G><I><E><N><R><T><E><G><T><D><S><P><L><S><R><D><W><R><P><G><S><P><G><T><Y><L><E><T><S><W><E><E><Q><L><L><E><Q><Q><E><Y><L><E><K><E><M><E><E><A><K><K><M><I><S><G><L><Q><A><L><L><L><N><G><S><L><P><E><D><E><Q><E><R><P><L><A><L><C><E><P><G><V><N><P><E><E><Q><L><I><I><I><Q><S><R><L><D><Q><S><M><E><E><N><Q><D><L><K><K><E><L><L><K><C><K><Q><E><A><R><N><L><Q><G><I><K><D><A><L><Q><Q><R><L><T><Q><Q><D><T><S><V><L><Q><L><K><Q><E><L><L><R><A><N><M><D><K><D><E><L><H><N><Q><N><V><D><L><Q><R><K><L><D><E><R><N><R><L><L><G><E><Y><K><K><E><L><G><Q><K><D><R><L><L><Q><Q><H><Q><A><K><L><E><E><A><L><R><K><L><S><D><V><S><Y><H><Q><V><D><L><E><R><E><L><E><H><K><D><V><L><L><A><H><C><M><K><R><E><A><D><E><A><T><N><Y><N><S><H><N><S><Q><S><N><G><F><L><L><P><T><A><G><K><G><A><T><S><V><S><N><R><G><T><S><D><L><Q><L><V><R><D><A><L><R><S><L><R><N><S><F><S><G><H><D><P><Q><H><H><T><I><D><S><L><E><Q><G><I><S><S><L><M><E><R><L><H><V><M><E><T><Q><K><K><Q><E><R><K><V><R><V><K><S><P><R><T><Q><V><G><S><E><Y><R><E><S><W><P><P><N><S><K><L><P><H><S><Q><S><S><P><T><V><S><S><T><C><T><K><V><L><Y><F><T><D><R><S><L><T><P><F><M><V><N><I><P><K><R><L><E><E><V><T><L><K><D><F><K><A><A><I><D><R><E><G><N><H><R><Y><H><F><K><A><L><D><P><E><F><G><T><V><K><E><E><I><F><H><D><D><D><A><I><P><G><W><E><G><K><I><V><A><W><V><E><E><D><H><G><E><N>
Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.<BOP>
Q155Q3
Q86YD1
PTOV1_HUMAN
Activator interaction domain-containing protein 2
Homo
<M><V><R><P><R><R><A><P><Y><R><S><G><A><G><G><P><L><G><G><R><G><R><P><P><R><P><L><V><V><R><A><V><R><S><R><S><W><P><A><S><P><R><G><P><Q><P><P><R><I><R><A><R><S><A><P><P><M><E><G><A><R><V><F><G><A><L><G><P><I><G><P><S><S><P><G><L><T><L><G><G><L><A><V><S><E><H><R><L><S><N><K><L><L><A><W><S><G><V><L><E><W><Q><E><K><R><R><P><Y><S><D><S><T><A><K><L><K><R><T><L><P><C><Q><A><Y><V><N><Q><G><E><N><L><E><T><D><Q><W><P><Q><K><L><I><M><Q><L><I><P><Q><Q><L><L><T><T><L><G><P><L><F><R><N><S><Q><L><A><Q><F><H><F><T><N><R><D><C><D><S><L><K><G><L><C><R><I><M><G><N><G><F><A><G><C><M><L><F><P><H><I><S><P><C><E><V><R><V><L><M><L><L><Y><S><S><K><K><K><I><F><M><G><L><I><P><Y><D><Q><S><G><F><V><S><A><I><R><Q><V><I><T><T><R><K><Q><A><V><G><P><G><G><V><N><S><G><P><V><Q><I><V><N><N><K><F><L><A><W><S><G><V><M><E><W><Q><E><P><R><P><E><P><N><S><R><S><K><R><W><L><P><S><H><V><Y><V><N><Q><G><E><I><L><R><T><E><Q><W><P><R><K><L><Y><M><Q><L><I><P><Q><Q><L><L><T><T><L><V><P><L><F><R><N><S><R><L><V><Q><F><H><F><T><K><D><L><E><T><L><K><S><L><C><R><I><M><D><N><G><F><A><G><C><V><H><F><S><Y><K><A><S><C><E><I><R><V><L><M><L><L><Y><S><S><E><K><K><I><F><I><G><L><I><P><H><D><Q><G><N><F><V><N><G><I><R><R><V><I><A><N><Q><Q><Q><V><L><Q><R><N><L><E><Q><E><Q><Q><Q><R><G><M><G><G>
May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.<BOP>
Q86YD1
O43614
OX2R_HUMAN
Hypocretin receptor type 2
Homo
<M><S><G><T><K><L><E><D><S><P><P><C><R><N><W><S><S><A><S><E><L><N><E><T><Q><E><P><F><L><N><P><T><D><Y><D><D><E><E><F><L><R><Y><L><W><R><E><Y><L><H><P><K><E><Y><E><W><V><L><I><A><G><Y><I><I><V><F><V><V><A><L><I><G><N><V><L><V><C><V><A><V><W><K><N><H><H><M><R><T><V><T><N><Y><F><I><V><N><L><S><L><A><D><V><L><V><T><I><T><C><L><P><A><T><L><V><V><D><I><T><E><T><W><F><F><G><Q><S><L><C><K><V><I><P><Y><L><Q><T><V><S><V><S><V><S><V><L><T><L><S><C><I><A><L><D><R><W><Y><A><I><C><H><P><L><M><F><K><S><T><A><K><R><A><R><N><S><I><V><I><I><W><I><V><S><C><I><I><M><I><P><Q><A><I><V><M><E><C><S><T><V><F><P><G><L><A><N><K><T><T><L><F><T><V><C><D><E><R><W><G><G><E><I><Y><P><K><M><Y><H><I><C><F><F><L><V><T><Y><M><A><P><L><C><L><M><V><L><A><Y><L><Q><I><F><R><K><L><W><C><R><Q><I><P><G><T><S><S><V><V><Q><R><K><W><K><P><L><Q><P><V><S><Q><P><R><G><P><G><Q><P><T><K><S><R><M><S><A><V><A><A><E><I><K><Q><I><R><A><R><R><K><T><A><R><M><L><M><I><V><L><L><V><F><A><I><C><Y><L><P><I><S><I><L><N><V><L><K><R><V><F><G><M><F><A><H><T><E><D><R><E><T><V><Y><A><W><F><T><F><S><H><W><L><V><Y><A><N><S><A><A><N><P><I><I><Y><N><F><L><S><G><K><F><R><E><E><F><K><A><A><F><S><C><C><C><L><G><V><H><H><R><Q><E><D><R><L><T><R><G><R><T><S><T><E><S><R><K><S><L><T><T><Q><I><S><N><F><D><N><I><S><K><L><S><E><Q><V><V><L><T><S><I><S><T><L><P><A><A><N><G><A><G><P><L><Q><N><W>
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides . Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding .<BOP>
O43614
P23219
PGH1_HUMAN
Prostaglandin-endoperoxide synthase 1
Homo
<M><S><R><S><L><L><L><W><F><L><L><F><L><L><L><L><P><P><L><P><V><L><L><A><D><P><G><A><P><T><P><V><N><P><C><C><Y><Y><P><C><Q><H><Q><G><I><C><V><R><F><G><L><D><R><Y><Q><C><D><C><T><R><T><G><Y><S><G><P><N><C><T><I><P><G><L><W><T><W><L><R><N><S><L><R><P><S><P><S><F><T><H><F><L><L><T><H><G><R><W><F><W><E><F><V><N><A><T><F><I><R><E><M><L><M><R><L><V><L><T><V><R><S><N><L><I><P><S><P><P><T><Y><N><S><A><H><D><Y><I><S><W><E><S><F><S><N><V><S><Y><Y><T><R><I><L><P><S><V><P><K><D><C><P><T><P><M><G><T><K><G><K><K><Q><L><P><D><A><Q><L><L><A><R><R><F><L><L><R><R><K><F><I><P><D><P><Q><G><T><N><L><M><F><A><F><F><A><Q><H><F><T><H><Q><F><F><K><T><S><G><K><M><G><P><G><F><T><K><A><L><G><H><G><V><D><L><G><H><I><Y><G><D><N><L><E><R><Q><Y><Q><L><R><L><F><K><D><G><K><L><K><Y><Q><V><L><D><G><E><M><Y><P><P><S><V><E><E><A><P><V><L><M><H><Y><P><R><G><I><P><P><Q><S><Q><M><A><V><G><Q><E><V><F><G><L><L><P><G><L><M><L><Y><A><T><L><W><L><R><E><H><N><R><V><C><D><L><L><K><A><E><H><P><T><W><G><D><E><Q><L><F><Q><T><T><R><L><I><L><I><G><E><T><I><K><I><V><I><E><E><Y><V><Q><Q><L><S><G><Y><F><L><Q><L><K><F><D><P><E><L><L><F><G><V><Q><F><Q><Y><R><N><R><I><A><M><E><F><N><H><L><Y><H><W><H><P><L><M><P><D><S><F><K><V><G><S><Q><E><Y><S><Y><E><Q><F><L><F><N><T><S><M><L><V><D><Y><G><V><E><A><L><V><D><A><F><S><R><Q><I><A><G><R><I><G><G><G><R><N><M><D><H><H><I><L><H><V><A><V><D><V><I><R><E><S><R><E><M><R><L><Q><P><F><N><E><Y><R><K><R><F><G><M><K><P><Y><T><S><F><Q><E><L><V><G><E><K><E><M><A><A><E><L><E><E><L><Y><G><D><I><D><A><L><E><F><Y><P><G><L><L><L><E><K><C><H><P><N><S><I><F><G><E><S><M><I><E><I><G><A><P><F><S><L><K><G><L><L><G><N><P><I><C><S><P><E><Y><W><K><P><S><T><F><G><G><E><V><G><F><N><I><V><K><T><A><T><L><K><K><L><V><C><L><N><T><K><T><C><P><Y><V><S><F><R><V><P><D><A><S><Q><D><D><G><P><A><V><E><R><P><S><T><E><L>
Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons . Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins
P23219
O75112
LDB3_HUMAN
Z-band alternatively spliced PDZ-motif protein
Homo
<M><S><Y><S><V><T><L><T><G><P><G><P><W><G><F><R><L><Q><G><G><K><D><F><N><M><P><L><T><I><S><R><I><T><P><G><S><K><A><A><Q><S><Q><L><S><Q><G><D><L><V><V><A><I><D><G><V><N><T><D><T><M><T><H><L><E><A><Q><N><K><I><K><S><A><S><Y><N><L><S><L><T><L><Q><K><S><K><R><P><I><P><I><S><T><T><A><P><P><V><Q><T><P><L><P><V><I><P><H><Q><K><D><P><A><L><D><T><N><G><S><L><V><A><P><S><P><S><P><E><A><R><A><S><P><G><T><P><G><T><P><E><L><R><P><T><F><S><P><A><F><S><R><P><S><A><F><S><S><L><A><E><A><S><D><P><G><P><P><R><A><S><L><R><A><K><T><S><P><E><G><A><R><D><L><L><G><P><K><A><L><P><G><S><S><Q><P><R><Q><Y><N><N><P><I><G><L><Y><S><A><E><T><L><R><E><M><A><Q><M><Y><Q><M><S><L><R><G><K><A><S><G><V><G><L><P><G><G><S><L><P><I><K><D><L><A><V><D><S><A><S><P><V><Y><Q><A><V><I><K><S><Q><N><K><P><E><D><E><A><D><E><W><A><R><R><S><S><N><L><Q><S><R><S><F><R><I><L><A><Q><M><T><G><T><E><F><M><Q><D><P><D><E><E><A><L><R><R><S><S><T><P><I><E><H><A><P><V><C><T><S><Q><A><T><T><P><L><L><P><A><S><A><Q><P><P><A><A><A><S><P><S><A><A><S><P><P><L><A><T><A><A><A><H><T><A><I><A><S><A><S><T><T><A><P><A><S><S><P><A><D><S><P><R><P><Q><A><S><S><Y><S><P><A><V><A><A><S><S><A><P><A><T><H><T><S><Y><S><E><G><P><A><A><P><A><P><K><P><R><V><V><T><T><A><S><I><R><P><S><V><Y><Q><P><V><P><A><S><T><Y><S><P><S><P><G><A><N><Y><S><P><T><P><Y><T><P><S><P><A><P><A><Y><T><P><S><P><A><P><A><Y><T><P><S><P><V><P><T><Y><T><P><S><P><A><P><A><Y><T><P><S><P><A><P><N><Y><N><P><A><P><S><V><A><Y><S><G><G><P><A><E><P><A><S><R><P><P><W><V><T><D><D><S><F><S><Q><K><F><A><P><G><K><S><T><T><S><I><S><K><Q><T><L><P><R><G><G><P><A><Y><T><P><A><G><P><Q><V><P><P><L><A><R><G><T><V><Q><R><A><E><R><F><P><A><S><S><R><T><P><L><C><G><H><C><N><N><V><I><R><G><P><F><L><V><A><M><G><R><S><W><H><P><E><E><F><T><C><A><Y><C><K><T><S><L><A><D><V><C><F><V><E><E><Q><N><N><V><Y><C><E><R><C><Y><E><Q><F><F><A><P><L><C><A><K><C><N><T><K><I><M><G><E><V><M><H><A><L><R><Q><T><W><H><T><T><C><F><V><C><A><A><C><K><K><P><F><G><N><S><L><F><H><M><E><D><G><E><P><Y><C><E><K><D><Y><I><N><L><F><S><T><K><C><H><G><C><D><F><P><V><E><A><G><D><K><F><I><E><A><L><G><H><T><W><H><D><T><C><F><I><C><A><V><C><H><V><N><L><E><G><Q><P><F><Y><S><K><K><D><R><P><L><C><K><K><H><A><H><T><I><N><L>
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.<BOP>
O75112
Q6ZMD2
SPNS3_HUMAN
Protein spinster homolog 3
Homo
<M><A><G><G><M><S><A><E><C><P><E><P><G><P><G><G><L><Q><G><Q><S><P><G><P><G><R><Q><C><P><P><P><I><T><P><T><S><W><S><L><P><P><W><R><A><Y><V><A><A><A><V><L><C><Y><I><N><L><L><N><Y><M><N><W><F><I><I><A><G><V><L><L><D><I><Q><E><V><F><Q><I><S><D><N><H><A><G><L><L><Q><T><V><F><V><S><C><L><L><L><S><A><P><V><F><G><Y><L><G><D><R><H><S><R><K><A><T><M><S><F><G><I><L><L><W><S><G><A><G><L><S><S><S><F><I><S><P><R><Y><S><W><L><F><F><L><S><R><G><I><V><G><T><G><S><A><S><Y><S><T><I><A><P><T><V><L><G><D><L><F><V><R><D><Q><R><T><R><V><L><A><V><F><Y><I><F><I><P><V><G><S><G><L><G><Y><V><L><G><S><A><V><T><M><L><T><G><N><W><R><W><A><L><R><V><M><P><C><L><E><A><V><A><L><I><L><L><I><L><L><V><P><D><P><P><R><G><A><A><E><T><Q><G><E><G><A><V><G><G><F><R><S><S><W><C><E><D><V><R><Y><L><G><K><N><W><S><F><V><W><S><T><L><G><V><T><A><M><A><F><V><T><G><A><L><G><F><W><A><P><K><F><L><L><E><A><R><V><V><H><G><L><Q><P><P><C><F><Q><E><P><C><S><N><P><D><S><L><I><F><G><A><L><T><I><M><T><G><V><I><G><V><I><L><G><A><E><A><A><R><R><Y><K><K><V><I><P><G><A><E><P><L><I><C><A><S><S><L><L><A><T><A><P><C><L><Y><L><A><L><V><L><A><P><T><T><L><L><A><S><Y><V><F><L><G><L><G><E><L><L><L><S><C><N><W><A><V><V><A><D><I><L><L><S><V><V><V><P><R><C><R><G><T><A><E><A><L><Q><I><T><V><G><H><I><L><G><D><A><G><S><P><Y><L><T><G><L><I><S><S><V><L><R><A><R><R><P><D><S><Y><L><Q><R><F><R><S><L><Q><Q><S><F><L><C><C><A><F><V><I><A><L><G><G><G><C><F><L><L><T><A><L><Y><L><E><R><D><E><T><R><A><W><Q><P><V><T><G><T><P><D><S><N><D><V><D><S><N><D><L><E><R><Q><G><L><L><S><G><A><G><A><S><T><E><E><P>
Sphingolipid transporter.<BOP>
Q6ZMD2
P41597
CCR2_HUMAN
Monocyte chemoattractant protein 1 receptor
Homo
<M><L><S><T><S><R><S><R><F><I><R><N><T><N><E><S><G><E><E><V><T><T><F><F><D><Y><D><Y><G><A><P><C><H><K><F><D><V><K><Q><I><G><A><Q><L><L><P><P><L><Y><S><L><V><F><I><F><G><F><V><G><N><M><L><V><V><L><I><L><I><N><C><K><K><L><K><C><L><T><D><I><Y><L><L><N><L><A><I><S><D><L><L><F><L><I><T><L><P><L><W><A><H><S><A><A><N><E><W><V><F><G><N><A><M><C><K><L><F><T><G><L><Y><H><I><G><Y><F><G><G><I><F><F><I><I><L><L><T><I><D><R><Y><L><A><I><V><H><A><V><F><A><L><K><A><R><T><V><T><F><G><V><V><T><S><V><I><T><W><L><V><A><V><F><A><S><V><P><G><I><I><F><T><K><C><Q><K><E><D><S><V><Y><V><C><G><P><Y><F><P><R><G><W><N><N><F><H><T><I><M><R><N><I><L><G><L><V><L><P><L><L><I><M><V><I><C><Y><S><G><I><L><K><T><L><L><R><C><R><N><E><K><K><R><H><R><A><V><R><V><I><F><T><I><M><I><V><Y><F><L><F><W><T><P><Y><N><I><V><I><L><L><N><T><F><Q><E><F><F><G><L><S><N><C><E><S><T><S><Q><L><D><Q><A><T><Q><V><T><E><T><L><G><M><T><H><C><C><I><N><P><I><I><Y><A><F><V><G><E><K><F><R><S><L><F><H><I><A><L><G><C><R><I><A><P><L><Q><K><P><V><C><G><G><P><G><V><R><P><G><K><N><V><K><V><T><T><Q><G><L><L><D><G><R><G><K><G><K><S><I><G><R><A><P><E><A><S><L><Q><D><K><E><G><A>
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.<BOP>
P41597
O95059
RPP14_HUMAN
Ribonuclease P protein subunit p14
Homo
<M><P><A><P><A><A><T><Y><E><R><V><V><Y><K><N><P><S><E><Y><H><Y><M><K><V><C><L><E><F><Q><D><C><G><V><G><L><N><A><A><Q><F><K><Q><L><L><I><S><A><V><K><D><L><F><G><E><V><D><A><A><L><P><L><D><I><L><T><Y><E><E><K><T><L><S><A><I><L><R><I><C><S><S><G><L><V><K><L><W><S><S><L><T><L><L><G><S><Y><K><G><K><K><C><A><F><R><V><I><Q><V><S><P><F><L><L><A><L><S><G><N><S><R><E><L><V><L><D>
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.<BOP>
O95059
Q15049
MLC1_HUMAN
Membrane protein MLC1
Homo
<M><T><Q><E><P><F><R><E><E><L><A><Y><D><R><M><P><T><L><E><R><G><R><Q><D><P><A><S><Y><A><P><D><A><K><P><S><D><L><Q><L><S><K><R><L><P><P><C><F><S><H><K><T><W><V><F><S><V><L><M><G><S><C><L><L><V><T><S><G><F><S><L><Y><L><G><N><V><F><P><A><E><M><D><Y><L><R><C><A><A><G><S><C><I><P><S><A><I><V><S><F><T><V><S><R><R><N><A><N><V><I><P><N><F><Q><I><L><F><V><S><T><F><A><V><T><T><T><C><L><I><W><F><G><C><K><L><V><L><N><P><S><A><I><N><I><N><F><N><L><I><L><L><L><L><L><E><L><L><M><A><A><T><V><I><I><A><A><R><S><S><E><E><D><C><K><K><K><K><G><S><M><S><D><S><A><N><I><L><D><E><V><P><F><P><A><R><V><L><K><S><Y><S><V><V><E><V><I><A><G><I><S><A><V><L><G><G><I><I><A><L><N><V><D><D><S><V><S><G><P><H><L><S><V><T><F><F><W><I><L><V><A><C><F><P><S><A><I><A><S><H><V><A><A><E><C><P><S><K><C><L><V><E><V><L><I><A><I><S><S><L><T><S><P><L><L><F><T><A><S><G><Y><L><S><F><S><I><M><R><I><V><E><M><F><K><D><Y><P><P><A><I><K><P><S><Y><D><V><L><L><L><L><L><L><L><V><L><L><L><Q><A><G><L><N><T><G><T><A><I><Q><C><V><R><F><K><V><S><A><R><L><Q><G><A><S><W><D><T><Q><N><G><P><Q><E><R><L><A><G><E><V><A><R><S><P><L><K><E><F><D><K><E><K><A><W><R><A><V><V><V><Q><M><A><Q>
Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.<BOP>
Q15049
Q6NVV9
ADAM5_HUMAN
Putative transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II
Homo
<M><Q><T><S><I><L><I><K><S><S><C><R><P><Q><F><Q><R><R><F><H><H><R><M><Q><K><Q><I><Q><N><I><I><S><I><L><S><S><A><S><V><I><N><S><Y><D><E><N><D><I><R><H><S><K><P><L><L><V><Q><M><D><C><N><Y><N><G><Y><V><A><G><I><P><N><S><L><V><T><L><S><V><C><S><G><L><R><G><T><M><Q><L><K><N><I><S><Y><G><I><E><P><M><E><A><V><S><G><F><I><H><K><I><Y><E><E><K><Y><A><D><T><N><I><L><L><E><E><N><D><T><Y><T><W><F><N><S><E><Y><Q><V><R><K><S><S><E><K><T><D><F><I><K><L><F><P><R><Y><I><E><M><H><I><V><V><D><K><N><L><F><K><P><A><N><M><I><C><R><K><S><V><G><K><E><C><D><F><T><E><Y><C><N><G><D><L><P><Y><C><L><P><D><T><Y><V><R><D><G><E><Y><C><D><S><G><G><A><F><C><F><Q><G><K><C><R><T><F><D><K><Q><C><D><D><L><I><G><R><G><S><R><G><A><P><V><F><C><Y><D><E><I><N><T><R><G><D><N><F><G><N><C><G><T><A><H><C><L><F><Q><H><I><L><C><G><K><L><V><C><T><W><E><H><R><D><L><I><S><R><P><N><L><S><V><I><Y><A><H><V><R><D><Q><T><C><V><S><T><Y><L><P><R><R><T><P><P><P><V><N><S><P><I><S><I><T><S><Y><Y><S><A><E><D><R><D><E><T><F><V><Q><D><G><S><M><C><G><P><D><M><Y><C><F><E><M><H><C><K><H><V><R><F><L><M><N><L><K><L><C><D><A><S><N><H><C><D><R><H><G><V><C><N><N><F><N><H><C><H><C><E><K><G><Y><N><P><P><Y><C><Q><P><K><Q><G><A><F><G><S><I><D><D><G><H><L><V><P><P><T><E><R><S><Y><M><E><E><G><R>
This is a non catalytic metalloprotease-like protein.<BOP>
Q6NVV9
O00233
PSMD9_HUMAN
26S proteasome regulatory subunit p27
Homo
<M><S><D><E><E><A><R><Q><S><G><G><S><S><Q><A><G><V><V><T><V><S><D><V><Q><E><L><M><R><R><K><E><E><I><E><A><Q><I><K><A><N><Y><D><V><L><E><S><Q><K><G><I><G><M><N><E><P><L><V><D><C><E><G><Y><P><R><S><D><V><D><L><Y><Q><V><R><T><A><R><H><N><I><I><C><L><Q><N><D><H><K><A><V><M><K><Q><V><E><E><A><L><H><Q><L><H><A><R><D><K><E><K><Q><A><R><D><M><A><E><A><H><K><E><A><M><S><R><K><L><G><Q><S><E><S><Q><G><P><P><R><A><F><A><K><V><N><S><I><S><P><G><S><P><A><S><I><A><G><L><Q><V><D><D><E><I><V><E><F><G><S><V><N><T><Q><N><F><Q><S><L><H><N><I><G><S><V><V><Q><H><S><E><G><K><P><L><N><V><T><V><I><R><R><G><E><K><H><Q><L><R><L><V><P><T><R><W><A><G><K><G><L><L><G><C><N><I><I><P><L><Q><R>
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.<BOP>
O00233
P78562
PHEX_HUMAN
X-linked hypophosphatemia protein
Homo
<M><E><A><E><T><G><S><S><V><E><T><G><K><K><A><N><R><G><T><R><I><A><L><V><V><F><V><G><G><T><L><V><L><G><T><I><L><F><L><V><S><Q><G><L><L><S><L><Q><A><K><Q><E><Y><C><L><K><P><E><C><I><E><A><A><A><A><I><L><S><K><V><N><L><S><V><D><P><C><D><N><F><F><R><F><A><C><D><G><W><I><S><N><N><P><I><P><E><D><M><P><S><Y><G><V><Y><P><W><L><R><H><N><V><D><L><K><L><K><E><L><L><E><K><S><I><S><R><R><R><D><T><E><A><I><Q><K><A><K><I><L><Y><S><S><C><M><N><E><K><A><I><E><K><A><D><A><K><P><L><L><H><I><L><R><H><S><P><F><R><W><P><V><L><E><S><N><I><G><P><E><G><V><W><S><E><R><K><F><S><L><L><Q><T><L><A><T><F><R><G><Q><Y><S><N><S><V><F><I><R><L><Y><V><S><P><D><D><K><A><S><N><E><H><I><L><K><L><D><Q><A><T><L><S><L><A><V><R><E><D><Y><L><D><N><S><T><E><A><K><S><Y><R><D><A><L><Y><K><F><M><V><D><T><A><V><L><L><G><A><N><S><S><R><A><E><H><D><M><K><S><V><L><R><L><E><I><K><I><A><E><I><M><I><P><H><E><N><R><T><S><E><A><M><Y><N><K><M><N><I><S><E><L><S><A><M><I><P><Q><F><D><W><L><G><Y><I><K><K><V><I><D><T><R><L><Y><P><H><L><K><D><I><S><P><S><E><N><V><V><V><R><V><P><Q><Y><F><K><D><L><F><R><I><L><G><S><E><R><K><K><T><I><A><N><Y><L><V><W><R><M><V><Y><S><R><I><P><N><L><S><R><R><F><Q><Y><R><W><L><E><F><S><R><V><I><Q><G><T><T><T><L><L><P><Q><W><D><K><C><V><N><F><I><E><S><A><L><P><Y><V><V><G><K><M><F><V><D><V><Y><F><Q><E><D><K><K><E><M><M><E><E><L><V><E><G><V><R><W><A><F><I><D><M><L><E><K><E><N><E><W><M><D><A><G><T><K><R><K><A><K><E><K><A><R><A><V><L><A><K><V><G><Y><P><E><F><I><M><N><D><T><H><V><N><E><D><L><K><A><I><K><F><S><E><A><D><Y><F><G><N><V><L><Q><T><R><K><Y><L><A><Q><S><D><F><F><W><L><R><K><A><V><P><K><T><E><W><F><T><N><P><T><T><V><N><A><F><Y><S><A><S><T><N><Q><I><R><F><P><A><G><E><L><Q><K><P><F><F><W><G><T><E><Y><P><R><S><L><S><Y><G><A><I><G><V><I><V><G><H><E><F><T><H><G><F><D><N><N><G><R><K><Y><D><K><N><G><N><L><D><P><W><W><S><T><E><S><E><E><K><F><K><E><K><T><K><C><M><I><N><Q><Y><S><N><Y><Y><W><K><K><A><G><L><N><V><K><G><K><R><T><L><G><E><N><I><A><D><N><G><G><L><R><E><A><F><R><A><Y><R><K><W><I><N><D><R><R><Q><G><L><E><E><P><L><L><P><G><I><T><F><T><N><N><Q><L><F><F><L><S><Y><A><H><V><R><C><N><S><Y><R><P><E><A><A><R><E><Q><V><Q><I><G><A><H><S><P><P><Q><F><R><V><N><G><A><I><S><N><F><E><E><F><Q><K><A><F><N><C><P><P><N><S><T><M><N><R><G><M><D><S><C><R><L><W>
Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity . Cleaves ASARM peptides between Ser and Glu or Asp residues . Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide . Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides . Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation .<BOP>
P78562
Q96CS7
PKHB2_HUMAN
Evectin-2
Homo
<M><A><F><V><K><S><G><W><L><L><R><Q><S><T><I><L><K><R><W><K><K><N><W><F><D><L><W><S><D><G><H><L><I><Y><Y><D><D><Q><T><R><Q><N><I><E><D><K><V><H><M><P><M><D><C><I><N><I><R><T><G><Q><E><C><R><D><T><Q><P><P><D><G><K><S><K><D><C><M><L><Q><I><V><C><R><D><G><K><T><I><S><L><C><A><E><S><T><D><D><C><L><A><W><K><F><T><L><Q><D><S><R><T><N><T><A><Y><V><G><S><A><V><M><T><D><E><T><S><V><V><S><S><P><P><P><Y><T><A><Y><A><A><P><A><P><E><Q><A><Y><G><Y><G><P><Y><G><G><A><Y><P><P><G><T><Q><V><V><Y><A><A><N><G><Q><A><Y><A><V><P><Y><Q><Y><P><Y><A><G><L><Y><G><Q><Q><P><A><N><Q><V><I><I><R><E><R><Y><R><D><N><D><S><D><L><A><L><G><M><L><A><G><A><A><T><G><M><A><L><G><S><L><F><W><V><F>
Involved in retrograde transport of recycling endosomes.<BOP>
Q96CS7
P48059
LIMS1_HUMAN
Renal carcinoma antigen NY-REN-48
Homo
<M><A><N><A><L><A><S><A><T><C><E><R><C><K><G><G><F><A><P><A><E><K><I><V><N><S><N><G><E><L><Y><H><E><Q><C><F><V><C><A><Q><C><F><Q><Q><F><P><E><G><L><F><Y><E><F><E><G><R><K><Y><C><E><H><D><F><Q><M><L><F><A><P><C><C><H><Q><C><G><E><F><I><I><G><R><V><I><K><A><M><N><N><S><W><H><P><E><C><F><R><C><D><L><C><Q><E><V><L><A><D><I><G><F><V><K><N><A><G><R><H><L><C><R><P><C><H><N><R><E><K><A><R><G><L><G><K><Y><I><C><Q><K><C><H><A><I><I><D><E><Q><P><L><I><F><K><N><D><P><Y><H><P><D><H><F><N><C><A><N><C><G><K><E><L><T><A><D><A><R><E><L><K><G><E><L><Y><C><L><P><C><H><D><K><M><G><V><P><I><C><G><A><C><R><R><P><I><E><G><R><V><V><N><A><M><G><K><Q><W><H><V><E><H><F><V><C><A><K><C><E><K><P><F><L><G><H><R><H><Y><E><R><K><G><L><A><Y><C><E><T><H><Y><N><Q><L><F><G><D><V><C><F><H><C><N><R><V><I><E><G><D><V><V><S><A><L><N><K><A><W><C><V><N><C><F><A><C><S><T><C><N><T><K><L><T><L><K><N><K><F><V><E><F><D><M><K><P><V><C><K><K><C><Y><E><K><F><P><L><E><L><K><K><R><L><K><K><L><A><E><T><L><G><R><K>
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.<BOP>
P48059
Q8N8G2
VGLL2_HUMAN
Protein VITO1
Homo
<M><S><C><L><D><V><M><Y><Q><V><Y><G><P><P><Q><P><Y><F><A><A><A><Y><T><P><Y><H><Q><K><L><A><Y><Y><S><K><M><Q><E><A><Q><E><C><N><A><S><P><S><S><S><G><S><G><S><S><S><F><S><S><Q><T><P><A><S><I><K><E><E><E><G><S><P><E><K><E><R><P><P><E><A><E><Y><I><N><S><R><C><V><L><F><T><Y><F><Q><G><D><I><S><S><V><V><D><E><H><F><S><R><A><L><S><Q><P><S><S><Y><S><P><S><C><T><S><S><K><A><P><R><S><S><G><P><W><R><D><C><S><F><P><M><S><Q><R><S><F><P><A><S><F><W><N><S><A><Y><Q><A><P><V><P><P><P><L><G><S><P><L><A><T><A><H><S><E><L><P><F><A><A><A><D><P><Y><S><P><A><A><L><H><G><H><L><H><Q><G><A><T><E><P><W><H><H><A><H><P><H><H><A><H><P><H><H><P><Y><A><L><G><G><A><L><G><A><Q><A><A><P><Y><P><R><P><A><A><V><H><E><V><Y><A><P><H><F><D><P><R><Y><G><P><L><L><M><P><A><A><S><G><R><P><A><R><L><A><T><A><P><A><P><A><P><G><S><P><P><C><E><L><S><G><K><G><E><P><A><G><A><A><W><A><G><P><G><G><P><F><A><S><P><S><G><D><V><A><Q><G><L><G><L><S><V><D><S><A><R><R><Y><S><L><C><G><A><S><L><L><S>
May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles.<BOP>
Q8N8G2
Q86V88
MGDP1_HUMAN
Magnesium-dependent phosphatase 1
Homo
<M><A><R><L><P><K><L><A><V><F><D><L><D><Y><T><L><W><P><F><W><V><D><T><H><V><D><P><P><F><H><K><S><S><D><G><T><V><R><D><R><R><G><Q><D><V><R><L><Y><P><E><V><P><E><V><L><K><R><L><Q><S><L><G><V><P><G><A><A><A><S><R><T><S><E><I><E><G><A><N><Q><L><L><E><L><F><D><L><F><R><Y><F><V><H><R><E><I><Y><P><G><S><K><I><T><H><F><E><R><L><Q><Q><K><T><G><I><P><F><S><Q><M><I><F><F><D><D><E><R><R><N><I><V><D><V><S><K><L><G><V><T><C><I><H><I><Q><N><G><M><N><L><Q><T><L><S><Q><G><L><E><T><F><A><K><A><Q><T><G><P><L><R><S><S><L><E><E><S><P><F><E><A>
Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.<BOP>
Q86V88
A0A0A0MRZ9
LV552_HUMAN
Immunoglobulin lambda variable 5-52
Homo
<M><A><W><T><L><L><L><L><V><L><L><S><H><C><T><G><S><L><S><Q><P><V><L><T><Q><P><S><S><H><S><A><S><S><G><A><S><V><R><L><T><C><M><L><S><S><G><F><S><V><G><D><F><W><I><R><W><Y><Q><Q><K><P><G><N><P><P><R><Y><L><L><Y><Y><H><S><D><S><N><K><G><Q><G><S><G><V><P><S><R><F><S><G><S><N><D><A><S><A><N><A><G><I><L><R><I><S><G><L><Q><P><E><D><E><A><D><Y><Y><C><G><T><W><H><S><N><S><K><T>
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0A0A0MRZ9
O00764
PDXK_HUMAN
Pyridoxine kinase
Homo
<M><E><E><E><C><R><V><L><S><I><Q><S><H><V><I><R><G><Y><V><G><N><R><A><A><T><F><P><L><Q><V><L><G><F><E><I><D><A><V><N><S><V><Q><F><S><N><H><T><G><Y><A><H><W><K><G><Q><V><L><N><S><D><E><L><Q><E><L><Y><E><G><L><R><L><N><N><M><N><K><Y><D><Y><V><L><T><G><Y><T><R><D><K><S><F><L><A><M><V><V><D><I><V><Q><E><L><K><Q><Q><N><P><R><L><V><Y><V><C><D><P><V><L><G><D><K><W><D><G><E><G><S><M><Y><V><P><E><D><L><L><P><V><Y><K><E><K><V><V><P><L><A><D><I><I><T><P><N><Q><F><E><A><E><L><L><S><G><R><K><I><H><S><Q><E><E><A><L><R><V><M><D><M><L><H><S><M><G><P><D><T><V><V><I><T><S><S><D><L><P><S><P><Q><G><S><N><Y><L><I><V><L><G><S><Q><R><R><R><N><P><A><G><S><V><V><M><E><R><I><R><M><D><I><R><K><V><D><A><V><F><V><G><T><G><D><L><F><A><A><M><L><L><A><W><T><H><K><H><P><N><N><L><K><V><A><C><E><K><T><V><S><T><L><H><H><V><L><Q><R><T><I><Q><C><A><K><A><Q><A><G><E><G><V><R><P><S><P><M><Q><L><E><L><R><M><V><Q><S><K><R><D><I><E><D><P><E><I><V><V><Q><A><T><V><L>
Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions.<BOP>
O00764
Q9ULW5
RAB26_HUMAN
Ras-related protein Rab-26
Homo
<M><S><R><K><K><T><P><K><S><K><G><A><S><T><P><A><A><S><T><L><P><T><A><N><G><A><R><P><A><R><S><G><T><A><L><S><G><P><D><A><P><P><N><G><P><L><Q><P><G><R><P><S><L><G><G><G><V><D><F><Y><D><V><A><F><K><V><M><L><V><G><D><S><G><V><G><K><T><C><L><L><V><R><F><K><D><G><A><F><L><A><G><T><F><I><S><T><V><G><I><D><F><R><N><K><V><L><D><V><D><G><V><K><V><K><L><Q><M><W><D><T><A><G><Q><E><R><F><R><S><V><T><H><A><Y><Y><R><D><A><H><A><L><L><L><L><Y><D><V><T><N><K><A><S><F><D><N><I><Q><A><W><L><T><E><I><H><E><Y><A><Q><H><D><V><A><L><M><L><L><G><N><K><V><D><S><A><H><E><R><V><V><K><R><E><D><G><E><K><L><A><K><E><Y><G><L><P><F><M><E><T><S><A><K><T><G><L><N><V><D><L><A><F><T><A><I><A><K><E><L><K><Q><R><S><M><K><A><P><S><E><P><R><F><R><L><H><D><Y><V><K><R><E><G><R><G><A><S><C><C><R><P>
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.<BOP>
Q9ULW5
Q13098
CSN1_HUMAN
Protein MFH
Homo
<M><P><L><P><V><Q><V><F><N><L><Q><G><A><V><E><P><M><Q><I><D><V><D><P><Q><E><D><P><Q><N><A><P><D><V><N><Y><V><V><E><N><P><S><L><D><L><E><Q><Y><A><A><S><Y><S><G><L><M><R><I><E><R><L><Q><F><I><A><D><H><C><P><T><L><R><V><E><A><L><K><M><A><L><S><F><V><Q><R><T><F><N><V><D><M><Y><E><E><I><H><R><K><L><S><E><A><T><R><S><S><L><R><E><L><Q><N><A><P><D><A><I><P><E><S><G><V><E><P><P><A><L><D><T><A><W><V><E><A><T><R><K><K><A><L><L><K><L><E><K><L><D><T><D><L><K><N><Y><K><G><N><S><I><K><E><S><I><R><R><G><H><D><D><L><G><D><H><Y><L><D><C><G><D><L><S><N><A><L><K><C><Y><S><R><A><R><D><Y><C><T><S><A><K><H><V><I><N><M><C><L><N><V><I><K><V><S><V><Y><L><Q><N><W><S><H><V><L><S><Y><V><S><K><A><E><S><T><P><E><I><A><E><Q><R><G><E><R><D><S><Q><T><Q><A><I><L><T><K><L><K><C><A><A><G><L><A><E><L><A><A><R><K><Y><K><Q><A><A><K><C><L><L><L><A><S><F><D><H><C><D><F><P><E><L><L><S><P><S><N><V><A><I><Y><G><G><L><C><A><L><A><T><F><D><R><Q><E><L><Q><R><N><V><I><S><S><S><S><F><K><L><F><L><E><L><E><P><Q><V><R><D><I><I><F><K><F><Y><E><S><K><Y><A><S><C><L><K><M><L><D><E><M><K><D><N><L><L><L><D><M><Y><L><A><P><H><V><R><T><L><Y><T><Q><I><R><N><R><A><L><I><Q><Y><F><S><P><Y><V><S><A><D><M><H><R><M><A><A><A><F><N><T><T><V><A><A><L><E><D><E><L><T><Q><L><I><L><E><G><L><I><S><A><R><V><D><S><H><S><K><I><L><Y><A><R><D><V><D><Q><R><S><T><T><F><E><K><S><L><L><M><G><K><E><F><Q><R><R><A><K><A><M><M><L><R><A><A><V><L><R><N><Q><I><H><V><K><S><P><P><R><E><G><S><Q><G><E><L><T><P><A><N><S><Q><S><R><M><S><T><N><M>
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.<BOP>
Q13098
P84085
ARF5_HUMAN
ADP-ribosylation factor 5
Homo
<M><G><L><T><V><S><A><L><F><S><R><I><F><G><K><K><Q><M><R><I><L><M><V><G><L><D><A><A><G><K><T><T><I><L><Y><K><L><K><L><G><E><I><V><T><T><I><P><T><I><G><F><N><V><E><T><V><E><Y><K><N><I><C><F><T><V><W><D><V><G><G><Q><D><K><I><R><P><L><W><R><H><Y><F><Q><N><T><Q><G><L><I><F><V><V><D><S><N><D><R><E><R><V><Q><E><S><A><D><E><L><Q><K><M><L><Q><E><D><E><L><R><D><A><V><L><L><V><F><A><N><K><Q><D><M><P><N><A><M><P><V><S><E><L><T><D><K><L><G><L><Q><H><L><R><S><R><T><W><Y><V><Q><A><T><C><A><T><Q><G><T><G><L><Y><D><G><L><D><W><L><S><H><E><L><S><K><R>
(Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.<BOP>
P84085
C9JJH3
U17LA_HUMAN
Ubiquitin carboxyl-terminal hydrolase 17-like protein 10
Homo
<M><E><D><D><S><L><Y><L><G><G><E><W><Q><F><N><H><F><S><K><L><T><S><S><R><P><D><A><A><F><A><E><I><Q><R><T><S><L><P><E><K><S><P><L><S><C><E><T><R><V><D><L><C><D><D><L><A><P><V><A><R><Q><L><A><P><R><E><K><P><P><L><S><S><R><R><P><A><A><V><G><A><G><L><Q><N><M><G><N><T><C><Y><V><N><A><S><L><Q><C><L><T><Y><K><P><P><L><A><N><Y><M><L><F><R><E><H><S><Q><T><C><H><R><H><K><G><C><M><L><C><T><M><Q><A><H><I><T><R><A><L><H><I><P><G><H><V><I><Q><P><S><Q><A><L><A><A><G><F><H><R><G><K><Q><E><D><A><H><E><F><L><M><F><T><V><D><A><M><R><K><A><C><L><P><G><H><K><Q><V><D><R><H><S><K><D><T><T><L><I><H><Q><I><F><G><G><Y><W><R><S><Q><I><K><C><L><H><C><H><G><I><S><D><T><F><D><P><Y><L><D><I><A><L><D><I><Q><A><A><Q><S><V><Q><Q><A><L><E><Q><L><V><K><P><E><E><L><N><G><E><N><A><Y><H><C><G><V><C><L><Q><R><A><P><A><S><K><T><L><T><L><H><N><S><A><K><V><L><I><L><V><L><K><R><F><P><D><V><T><G><N><K><I><A><K><N><V><Q><Y><P><E><C><L><D><M><Q><P><Y><M><S><Q><Q><N><T><G><P><L><V><Y><V><L><Y><A><V><L><V><H><A><G><W><S><C><H><N><G><H><Y><S><S><Y><V><K><A><Q><E><G><Q><W><Y><K><M><D><D><A><E><V><T><A><S><S><I><T><S><V><L><S><Q><Q><A><Y><V><L><F><Y><I><Q><K><S><E><W><E><R><H><S><E><S><V><S><R><G><R><E><P><R><A><L><G><V><E><D><T><D><R><R><A><T><Q><G><E><L><K><R><D><H><P><C><L><Q><A><P><E><L><D><E><H><L><V><E><R><A><T><Q><E><S><T><L><D><H><W><K><F><L><Q><E><Q><N><K><T><K><P><E><F><N><V><R><R><V><E><G><T><V><P><P><D><V><L><V><I><H><Q><S><K><Y><K><C><R><M><K><N><H><H><P><E><Q><Q><S><S><L><L><N><L><S><S><T><T><P><T><D><Q><E><S><M><N><T><G><T><L><A><S><L><R><G><R><T><R><R><S><K><G><K><N><K><H><S><K><R><A><L><L><V><C><Q>
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.<BOP>
C9JJH3
Q8NDF8
PAPD5_HUMAN
Topoisomerase-related function protein 4-2
Homo
<M><Y><R><S><G><E><R><L><L><G><S><H><A><L><P><A><E><Q><R><D><F><L><P><L><E><T><T><N><N><N><N><N><H><H><Q><P><G><A><W><A><R><R><A><G><S><S><A><S><S><P><P><S><A><S><S><S><P><H><P><S><A><A><V><P><A><A><D><P><A><D><S><A><S><G><S><S><N><K><R><K><R><D><N><K><A><S><G><G><R><A><A><G><G><G><R><A><D><G><G><G><V><V><Y><S><G><T><P><W><K><R><R><N><Y><N><Q><G><V><V><G><L><H><E><E><I><S><D><F><Y><E><Y><M><S><P><R><P><E><E><E><K><M><R><M><E><V><V><N><R><I><E><S><V><I><K><E><L><W><P><S><A><D><V><Q><I><F><G><S><F><K><T><G><L><Y><L><P><T><S><D><I><D><L><V><V><F><G><K><W><E><N><L><P><L><W><T><L><E><E><A><L><R><K><H><K><V><A><D><E><D><S><V><K><V><L><D><K><A><T><V><P><I><I><K><L><T><D><S><F><T><E><V><K><V><D><I><S><F><N><V><Q><N><G><V><R><A><A><D><L><I><K><D><F><T><K><K><Y><P><V><L><P><Y><L><V><L><V><L><K><Q><F><L><L><Q><R><D><L><N><E><V><F><T><G><G><I><G><S><Y><S><L><F><L><M><A><V><S><F><L><Q><L><H><P><R><E><D><A><C><I><P><N><T><N><Y><G><V><L><L><I><E><F><F><E><L><Y><G><R><H><F><N><Y><L><K><T><G><I><R><I><K><D><G><G><S><Y><V><A><K><D><E><V><Q><K><N><M><L><D><G><Y><R><P><S><M><L><Y><I><E><D><P><L><Q><P><G><N><D><V><G><R><S><S><Y><G><A><M><Q><V><K><Q><A><F><D><Y><A><Y><V><V><L><S><H><A><V><S><P><I><A><K><Y><Y><P><N><N><E><T><E><S><I><L><G><R><I><I><R><V><T><D><E><V><A><T><Y><R><D><W><I><S><K><Q><W><G><L><K><N><R><P><E><P><S><C><N><G><P><V><S><S><S><S><A><T><Q><S><S><S><S><D><V><D><S><D><A><T><P><C><K><T><P><K><Q><L><L><C><R><P><S><T><G><N><R><V><G><S><Q><D><V><S><L><E><S><S><Q><A><V><G><K><M><Q><S><T><Q><T><T><N><T><S><N><S><T><N><K><S><Q><H><G><S><A><R><L><F><R><S><S><S><K><G><F><Q><G><T><T><Q><T><S><H><G><S><L><M><T><N><K><Q><H><Q><G><K><S><N><N><Q><Y><Y><H><G><K><K><R><K><H><K><R><D><A><P><L><S><D><L><C><R>
Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation . Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) . Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 . Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion . Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation . Mediates 3' adenylation
Q8NDF8
Q9H0N0
RAB6C_HUMAN
Rab6-like protein WTH3
Homo
<M><S><A><G><G><D><F><G><N><P><L><R><K><F><K><L><V><F><L><G><E><Q><S><V><A><K><T><S><L><I><T><R><F><R><Y><D><S><F><D><N><T><Y><Q><A><I><I><G><I><D><F><L><S><K><T><M><Y><L><E><D><G><T><I><G><L><R><L><W><D><T><A><G><Q><E><R><L><R><S><L><I><P><R><Y><I><R><D><S><A><A><A><V><V><V><Y><D><I><T><N><V><N><S><F><Q><Q><T><T><K><W><I><D><D><V><R><T><E><R><G><S><D><V><I><I><T><L><V><G><N><R><T><D><L><A><D><K><R><Q><V><S><V><E><E><G><E><R><K><A><K><G><L><N><V><T><F><I><E><T><R><A><K><A><G><Y><N><V><K><Q><L><F><R><R><V><A><A><A><L><P><G><M><E><S><T><Q><D><G><S><R><E><D><M><S><D><I><K><L><E><K><P><Q><E><Q><T><V><S><E><G><G><C><S><C><Y><S><P><M><S><S><S><T><L><P><Q><K><P><P><Y><S><F><I><D><C><S><V><N><I><G><L><N><L><F><P><S><L><I><T><F><C><N><S><S><L><L><P><V><S><W><R>
May be involved in the regulation of centrosome duplication and cell cycle progression.<BOP>
Q9H0N0
Q96AQ7
CIDEC_HUMAN
Fat-specific protein FSP27 homolog
Homo
<M><E><Y><A><M><K><S><L><S><L><L><Y><P><K><S><L><S><R><H><V><S><V><R><T><S><V><V><T><Q><Q><L><L><S><E><P><S><P><K><A><P><R><A><R><P><C><R><V><S><T><A><D><R><S><V><R><K><G><I><M><A><Y><S><L><E><D><L><L><L><K><V><R><D><T><L><M><L><A><D><K><P><F><F><L><V><L><E><E><D><G><T><T><V><E><T><E><E><Y><F><Q><A><L><A><G><D><T><V><F><M><V><L><Q><K><G><Q><K><W><Q><P><P><S><E><Q><G><T><R><H><P><L><S><L><S><H><K><P><A><K><K><I><D><V><A><R><V><T><F><D><L><Y><K><L><N><P><Q><D><F><I><G><C><L><N><V><K><A><T><F><Y><D><T><Y><S><L><S><Y><D><L><H><C><C><G><A><K><R><I><M><K><E><A><F><R><W><A><L><F><S><M><Q><A><T><G><H><V><L><L><G><T><S><C><Y><L><Q><Q><L><L><D><A><T><E><E><G><Q><P><P><K><G><K><A><S><S><L><I><P><T><C><L><K><I><L><Q>
Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.<BOP>
Q96AQ7