accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q02790 | FKBP4_HUMAN | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed | Homo | <M><T><A><E><E><M><K><A><T><E><S><G><A><Q><S><A><P><L><P><M><E><G><V><D><I><S><P><K><Q><D><E><G><V><L><K><V><I><K><R><E><G><T><G><T><E><M><P><M><I><G><D><R><V><F><V><H><Y><T><G><W><L><L><D><G><T><K><F><D><S><S><L><D><R><K><D><K><F><S><F><D><L><G><K><G><E><V><I><K><A><W><D><I><A><I><A><T><M><K><V><G><E><V><C><H><I><T><C><K><P><E><Y><A><Y><G><S><A><G><S><P><P><K><I><P><P><N><A><T><L><V><F><E><V><E><L><F><E><F><K><G><E><D><L><T><E><E><E><D><G><G><I><I><R><R><I><Q><T><R><G><E><G><Y><A><K><P><N><E><G><A><I><V><E><V><A><L><E><G><Y><Y><K><D><K><L><F><D><Q><R><E><L><R><F><E><I><G><E><G><E><N><L><D><L><P><Y><G><L><E><R><A><I><Q><R><M><E><K><G><E><H><S><I><V><Y><L><K><P><S><Y><A><F><G><S><V><G><K><E><K><F><Q><I><P><P><N><A><E><L><K><Y><E><L><H><L><K><S><F><E><K><A><K><E><S><W><E><M><N><S><E><E><K><L><E><Q><S><T><I><V><K><E><R><G><T><V><Y><F><K><E><G><K><Y><K><Q><A><L><L><Q><Y><K><K><I><V><S><W><L><E><Y><E><S><S><F><S><N><E><E><A><Q><K><A><Q><A><L><R><L><A><S><H><L><N><L><A><M><C><H><L><K><L><Q><A><F><S><A><A><I><E><S><C><N><K><A><L><E><L><D><S><N><N><E><K><G><L><F><R><R><G><E><A><H><L><A><V><N><D><F><E><L><A><R><A><D><F><Q><K><V><L><Q><L><Y><P><N><N><K><A><A><K><T><Q><L><A><V><C><Q><Q><R><I><R><R><Q><L><A><R><E><K><K><L><Y><A><N><M><F><E><R><L><A><E><E><E><N><K><A><K><A><E><A><S><S><G><D><H><P><T><D><T><E><M><K><E><E><Q><K><S><N><T><A><G><S><Q><S><Q><V><E><T><E><A> | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.<BOP> | Q02790 |
O75915 | PRAF3_HUMAN | Putative MAPK-activating protein PM27 | Homo | <M><D><V><N><I><A><P><L><R><A><W><D><D><F><F><P><G><S><D><R><F><A><R><P><D><F><R><D><I><S><K><W><N><N><R><V><V><S><N><L><L><Y><Y><Q><T><N><Y><L><V><V><A><A><M><M><I><S><I><V><G><F><L><S><P><F><N><M><I><L><G><G><I><V><V><V><L><V><F><T><G><F><V><W><A><A><H><N><K><D><V><L><R><R><M><K><K><R><Y><P><T><T><F><V><M><V><V><M><L><A><S><Y><F><L><I><S><M><F><G><G><V><M><V><F><V><F><G><I><T><F><P><L><L><L><M><F><I><H><A><S><L><R><L><R><N><L><K><N><K><L><E><N><K><M><E><G><I><G><L><K><R><T><P><M><G><I><V><L><D><A><L><E><Q><Q><E><E><G><I><N><R><L><T><D><Y><I><S><K><V><K><E> | Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum.<BOP> | O75915 |
P47893 | OR3A2_HUMAN | Olfactory receptor OR17-14 | Homo | <M><S><L><Q><K><L><M><E><P><E><A><G><T><N><R><T><A><V><A><E><F><I><L><L><G><L><V><Q><T><E><E><M><Q><P><V><V><F><V><L><L><L><F><A><Y><L><V><T><T><G><G><N><L><S><I><L><A><A><V><L><V><E><P><K><L><H><A><P><M><Y><F><F><L><G><N><L><S><V><L><D><V><G><C><I><T><V><T><V><P><A><M><L><G><R><L><L><S><H><K><S><T><I><S><Y><D><A><C><L><S><Q><L><F><F><F><H><L><L><A><G><M><D><C><F><L><L><T><A><M><A><Y><D><R><L><L><A><I><C><Q><P><L><T><Y><S><T><R><M><S><Q><T><V><Q><R><M><L><V><A><A><S><L><A><C><A><F><T><N><A><L><T><H><T><V><A><M><S><T><L><N><F><C><G><P><N><E><V><N><H><F><Y><C><D><L><P><Q><L><F><Q><L><S><C><S><S><T><Q><L><N><E><L><L><L><F><A><V><G><F><I><M><A><G><T><P><L><V><L><I><I><T><A><Y><S><H><V><A><A><A><V><L><R><I><R><S><V><E><G><R><K><K><A><F><S><T><C><G><S><H><L><T><V><V><C><L><F><F><G><R><G><I><F><N><Y><M><R><L><G><S><E><E><A><S><D><K><D><K><G><V><G><V><F><N><T><V><I><N><P><M><L><N><P><L><I><Y><S><L><R><N><P><D><V><Q><G><A><L><W><Q><I><F><L><G><R><R><S><L><T> | Odorant receptor.<BOP> | P47893 |
Q8N9R8 | SCAI_HUMAN | Suppressor of cancer cell invasion protein | Homo | <M><V><R><G><A><R><Q><P><Q><Q><P><R><S><R><L><A><P><R><L><T><G><T><V><E><K><P><P><R><K><R><R><S><R><T><E><F><A><L><K><E><I><M><S><S><G><G><A><E><D><D><I><P><Q><G><E><R><K><T><V><T><D><F><C><Y><L><L><D><K><S><K><Q><L><F><N><G><L><R><D><L><P><Q><Y><G><Q><K><Q><W><Q><S><Y><F><G><R><T><F><D><V><Y><T><K><L><W><K><F><Q><Q><Q><H><R><Q><V><L><D><N><R><Y><G><L><K><R><W><Q><I><G><E><I><A><S><K><I><G><Q><L><Y><Y><H><Y><Y><L><R><T><S><E><T><S><Y><L><N><E><A><F><S><F><Y><S><A><I><R><Q><R><S><Y><Y><S><Q><V><N><K><E><D><R><P><E><L><V><V><K><K><L><R><Y><Y><A><R><F><I><V><V><C><L><L><L><N><K><M><D><V><V><K><D><L><V><K><E><L><S><D><E><I><E><D><Y><T><H><R><F><N><T><E><D><Q><V><E><W><N><L><V><L><Q><E><V><A><A><F><I><E><A><D><P><V><M><V><L><N><D><D><N><T><I><V><I><T><S><N><R><L><A><E><T><G><A><P><L><L><E><Q><G><M><I><V><G><Q><L><S><L><A><D><A><L><I><I><G><N><C><N><N><Q><V><K><F><S><E><L><T><V><D><M><F><R><M><L><Q><A><L><E><R><E><P><M><N><L><A><S><Q><M><N><K><P><G><M><Q><E><S><A><D><K><P><T><R><R><E><N><P><H><K><Y><L><L><Y><K><P><T><F><S><Q><L><Y><T><F><L><A><A><S><F><K><E><L><P><A><N><S><V><L><L><I><Y><L><S><A><T><G><V><F><P><T><G><R><S><D><S><E><G><P><Y><D><F><G><G><V><L><T><N><S><N><R><D><I><I><N><G><D><A><I><H><K><R><N><Q><S><H><K><E><M><H><C><L><H><P><G><D><L><Y><P><F><T><R><K><P><L><F><I><I><V><D><S><S><N><S><V><A><Y><K><N><F><T><N><L><F><G><Q><P><L><V><C><L><L><S><P><T><A><Y><P><K><A><L><Q><D><Q><S><Q><R><G><S><L><F><T><L><F><L><N><N><P><L><M><A><F><L><F><V><S><G><L><S><S><M><R><R><G><L><W><E><K><C><Q><E><Y><L><R><K><I><N><R><D><I><A><Q><L><L><T><H><S><R><S><I><D><Q><A><F><L><Q><F><F><G><D><E><F><L><R><L><L><L><T><R><F><I><F><C><S><A><T><M><R><M><H><K><I><F><R><E><T><R><N><Y><P><E><S><Y><P><Q><L><P><R><D><E><T><V><E><N><P><H><L><Q><K><H><I><L><E><L><A><S><I><L><D><V><R><N><V><F><F><E><N><T><I><D><D><Y> | Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.<BOP> | Q8N9R8 |
Q04446 | GLGB_HUMAN | Glycogen-branching enzyme | Homo | <M><A><A><P><M><T><P><A><A><R><P><E><D><Y><E><A><A><L><N><A><A><L><A><D><V><P><E><L><A><R><L><L><E><I><D><P><Y><L><K><P><Y><A><V><D><F><Q><R><R><Y><K><Q><F><S><Q><I><L><K><N><I><G><E><N><E><G><G><I><D><K><F><S><R><G><Y><E><S><F><G><V><H><R><C><A><D><G><G><L><Y><C><K><E><W><A><P><G><A><E><G><V><F><L><T><G><D><F><N><G><W><N><P><F><S><Y><P><Y><K><K><L><D><Y><G><K><W><E><L><Y><I><P><P><K><Q><N><K><S><V><L><V><P><H><G><S><K><L><K><V><V><I><T><S><K><S><G><E><I><L><Y><R><I><S><P><W><A><K><Y><V><V><R><E><G><D><N><V><N><Y><D><W><I><H><W><D><P><E><H><S><Y><E><F><K><H><S><R><P><K><K><P><R><S><L><R><I><Y><E><S><H><V><G><I><S><S><H><E><G><K><V><A><S><Y><K><H><F><T><C><N><V><L><P><R><I><K><G><L><G><Y><N><C><I><Q><L><M><A><I><M><E><H><A><Y><Y><A><S><F><G><Y><Q><I><T><S><F><F><A><A><S><S><R><Y><G><T><P><E><E><L><Q><E><L><V><D><T><A><H><S><M><G><I><I><V><L><L><D><V><V><H><S><H><A><S><K><N><S><A><D><G><L><N><M><F><D><G><T><D><S><C><Y><F><H><S><G><P><R><G><T><H><D><L><W><D><S><R><L><F><A><Y><S><S><W><E><I><L><R><F><L><L><S><N><I><R><W><W><L><E><E><Y><R><F><D><G><F><R><F><D><G><V><T><S><M><L><Y><H><H><H><G><V><G><Q><G><F><S><G><D><Y><S><E><Y><F><G><L><Q><V><D><E><D><A><L><T><Y><L><M><L><A><N><H><L><V><H><T><L><C><P><D><S><I><T><I><A><E><D><V><S><G><M><P><A><L><C><S><P><I><S><Q><G><G><G><G><F><D><Y><R><L><A><M><A><I><P><D><K><W><I><Q><L><L><K><E><F><K><D><E><D><W><N><M><G><D><I><V><Y><T><L><T><N><R><R><Y><L><E><K><C><I><A><Y><A><E><S><H><D><Q><A><L><V><G><D><K><S><L><A><F><W><L><M><D><A><E><M><Y><T><N><M><S><V><L><T><P><F><T><P><V><I><D><R><G><I><Q><L><H><K><M><I><R><L><I><T><H><G><L><G><G><E><G><Y><L><N><F><M><G><N><E><F><G><H><P><E><W><L><D><F><P><R><K><G><N><N><E><S><Y><H><Y><A><R><R><Q><F><H><L><T><D><D><D><L><L><R><Y><K><F><L><N><N><F><D><R><D><M><N><R><L><E><E><R><Y><G><W><L><A><A><P><Q><A><Y><V><S><E><K><H><E><G><N><K><I><I><A><F><E><R><A><G><L><L><F><I><F><N><F><H><P><S><K><S><Y><T><D><Y><R><V><G><T><A><L><P><G><K><F><K><I><V><L><D><S><D><A><A><E><Y><G><G><H><Q><R><L><D><H><S><T><D><F><F><S><E><A><F><E><H><N><G><R><P><Y><S><L><L><V><Y><I><P><S><R><V><A><L><I><L><Q><N><V><D><L><P><N> | Required for normal glycogen accumulation . The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule (Probable).<BOP> | Q04446 |
P24462 | CP3A7_HUMAN | P450HLp2 | Homo | <M><D><L><I><P><N><L><A><V><E><T><W><L><L><L><A><V><S><L><I><L><L><Y><L><Y><G><T><R><T><H><G><L><F><K><K><L><G><I><P><G><P><T><P><L><P><F><L><G><N><A><L><S><F><R><K><G><Y><W><T><F><D><M><E><C><Y><K><K><Y><R><K><V><W><G><I><Y><D><C><Q><Q><P><M><L><A><I><T><D><P><D><M><I><K><T><V><L><V><K><E><C><Y><S><V><F><T><N><R><R><P><F><G><P><V><G><F><M><K><N><A><I><S><I><A><E><D><E><E><W><K><R><I><R><S><L><L><S><P><T><F><T><S><G><K><L><K><E><M><V><P><I><I><A><Q><Y><G><D><V><L><V><R><N><L><R><R><E><A><E><T><G><K><P><V><T><L><K><H><V><F><G><A><Y><S><M><D><V><I><T><S><T><S><F><G><V><S><I><D><S><L><N><N><P><Q><D><P><F><V><E><N><T><K><K><L><L><R><F><N><P><L><D><P><F><V><L><S><I><K><V><F><P><F><L><T><P><I><L><E><A><L><N><I><T><V><F><P><R><K><V><I><S><F><L><T><K><S><V><K><Q><I><K><E><G><R><L><K><E><T><Q><K><H><R><V><D><F><L><Q><L><M><I><D><S><Q><N><S><K><D><S><E><T><H><K><A><L><S><D><L><E><L><M><A><Q><S><I><I><F><I><F><A><G><Y><E><T><T><S><S><V><L><S><F><I><I><Y><E><L><A><T><H><P><D><V><Q><Q><K><V><Q><K><E><I><D><T><V><L><P><N><K><A><P><P><T><Y><D><T><V><L><Q><L><E><Y><L><D><M><V><V><N><E><T><L><R><L><F><P><V><A><M><R><L><E><R><V><C><K><K><D><V><E><I><N><G><M><F><I><P><K><G><V><V><V><M><I><P><S><Y><V><L><H><H><D><P><K><Y><W><T><E><P><E><K><F><L><P><E><R><F><S><K><K><N><K><D><N><I><D><P><Y><I><Y><T><P><F><G><S><G><P><R><N><C><I><G><M><R><F><A><L><V><N><M><K><L><A><L><V><R><V><L><Q><N><F><S><F><K><P><C><K><E><T><Q><I><P><L><K><L><R><F><G><G><L><L><L><T><E><K><P><I><V><L><K><A><E><S><R><D><E><T><V><S><G><A> | A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones . Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position . Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development . Also involved in the oxidative metabolism of xenobiotics including anticonvulsants .<BOP> | P24462 |
Q16831 | UPP1_HUMAN | Uridine phosphorylase 1 | Homo | <M><A><A><T><G><A><N><A><E><K><A><E><S><H><N><D><C><P><V><R><L><L><N><P><N><I><A><K><M><K><E><D><I><L><Y><H><F><N><L><T><T><S><R><H><N><F><P><A><L><F><G><D><V><K><F><V><C><V><G><G><S><P><S><R><M><K><A><F><I><R><C><V><G><A><E><L><G><L><D><C><P><G><R><D><Y><P><N><I><C><A><G><T><D><R><Y><A><M><Y><K><V><G><P><V><L><S><V><S><H><G><M><G><I><P><S><I><S><I><M><L><H><E><L><I><K><L><L><Y><Y><A><R><C><S><N><V><T><I><I><R><I><G><T><S><G><G><I><G><L><E><P><G><T><V><V><I><T><E><Q><A><V><D><T><C><F><K><A><E><F><E><Q><I><V><L><G><K><R><V><I><R><K><T><D><L><N><K><K><L><V><Q><E><L><L><L><C><S><A><E><L><S><E><F><T><T><V><V><G><N><T><M><C><T><L><D><F><Y><E><G><Q><G><R><L><D><G><A><L><C><S><Y><T><E><K><D><K><Q><A><Y><L><E><A><A><Y><A><A><G><V><R><N><I><E><M><E><S><S><V><F><A><A><M><C><S><A><C><G><L><Q><A><A><V><V><C><V><T><L><L><N><R><L><E><G><D><Q><I><S><S><P><R><N><V><L><S><E><Y><Q><Q><R><P><Q><R><L><V><S><Y><F><I><K><K><K><L><S><K><A> | Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate . The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.<BOP> | Q16831 |
O00483 | NDUA4_HUMAN | NADH-ubiquinone oxidoreductase MLRQ subunit | Homo | <M><L><R><Q><I><I><G><Q><A><K><K><H><P><S><L><I><P><L><F><V><F><I><G><T><G><A><T><G><A><T><L><Y><L><L><R><L><A><L><F><N><P><D><V><C><W><D><R><N><N><P><E><P><W><N><K><L><G><P><N><D><Q><Y><K><F><Y><S><V><N><V><D><Y><S><K><L><K><K><E><R><P><D><F> | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons | O00483 |
P35998 | PRS7_HUMAN | Proteasome 26S subunit ATPase 2 | Homo | <M><P><D><Y><L><G><A><D><Q><R><K><T><K><E><D><E><K><D><D><K><P><I><R><A><L><D><E><G><D><I><A><L><L><K><T><Y><G><Q><S><T><Y><S><R><Q><I><K><Q><V><E><D><D><I><Q><Q><L><L><K><K><I><N><E><L><T><G><I><K><E><S><D><T><G><L><A><P><P><A><L><W><D><L><A><A><D><K><Q><T><L><Q><S><E><Q><P><L><Q><V><A><R><C><T><K><I><I><N><A><D><S><E><D><P><K><Y><I><I><N><V><K><Q><F><A><K><F><V><V><D><L><S><D><Q><V><A><P><T><D><I><E><E><G><M><R><V><G><V><D><R><N><K><Y><Q><I><H><I><P><L><P><P><K><I><D><P><T><V><T><M><M><Q><V><E><E><K><P><D><V><T><Y><S><D><V><G><G><C><K><E><Q><I><E><K><L><R><E><V><V><E><T><P><L><L><H><P><E><R><F><V><N><L><G><I><E><P><P><K><G><V><L><L><F><G><P><P><G><T><G><K><T><L><C><A><R><A><V><A><N><R><T><D><A><C><F><I><R><V><I><G><S><E><L><V><Q><K><Y><V><G><E><G><A><R><M><V><R><E><L><F><E><M><A><R><T><K><K><A><C><L><I><F><F><D><E><I><D><A><I><G><G><A><R><F><D><D><G><A><G><G><D><N><E><V><Q><R><T><M><L><E><L><I><N><Q><L><D><G><F><D><P><R><G><N><I><K><V><L><M><A><T><N><R><P><D><T><L><D><P><A><L><M><R><P><G><R><L><D><R><K><I><E><F><S><L><P><D><L><E><G><R><T><H><I><F><K><I><H><A><R><S><M><S><V><E><R><D><I><R><F><E><L><L><A><R><L><C><P><N><S><T><G><A><E><I><R><S><V><C><T><E><A><G><M><F><A><I><R><A><R><R><K><I><A><T><E><K><D><F><L><E><A><V><N><K><V><I><K><S><Y><A><K><F><S><A><T><P><R><Y><M><T><Y><N> | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.<BOP> | P35998 |
P09430 | STP1_HUMAN | Spermatid nuclear transition protein 1 | Homo | <M><S><T><S><R><K><L><K><S><H><G><M><R><R><S><K><S><R><S><P><H><K><G><V><K><R><G><G><S><K><R><K><Y><R><K><G><N><L><K><S><R><K><R><G><D><D><A><N><R><N><Y><R><S><H><L> | Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.<BOP> | P09430 |
Q9BRA0 | LSMD1_HUMAN | Phosphonoformate immuno-associated protein 2 | Homo | <M><A><G><A><G><P><T><M><L><L><R><E><E><N><G><C><C><S><R><R><Q><S><S><S><S><A><G><D><S><D><G><E><R><E><D><S><A><A><E><R><A><R><Q><Q><L><E><A><L><L><N><K><T><M><R><I><R><M><T><D><G><R><T><L><V><G><C><F><L><C><T><D><R><D><C><N><V><I><L><G><S><A><Q><E><F><L><K><P><S><D><S><F><S><A><G><E><P><R><V><L><G><L><A><M><V><P><G><H><H><I><V><S><I><E><V><Q><R><E><S><L><T><G><P><P><Y><L> | Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.<BOP> | Q9BRA0 |
A0A0A0MS06 | TVB23_HUMAN | Probable non-functional T cell receptor beta variable 23-1 | Homo | <M><G><T><R><L><L><G><C><A><A><L><C><L><L><A><A><D><S><F><H><A><K><V><T><Q><T><P><G><H><L><V><K><G><K><G><Q><K><T><K><M><D><C><T><P><E><K><G><H><T><F><V><Y><W><Y><Q><Q><N><Q><N><K><E><F><M><L><L><I><S><F><Q><N><E><Q><V><L><Q><E><T><E><M><H><K><K><R><F><S><S><Q><C><P><K><N><A><P><C><S><L><A><I><L><S><S><E><P><G><D><T><A><L><Y><L><C><A><S><S><Q> | Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain . Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK | A0A0A0MS06 |
Q8NHC7 | O14CZ_HUMAN | Olfactory receptor OR1-59 | Homo | <M><P><N><S><T><T><V><M><E><F><L><L><M><R><F><S><D><V><W><T><L><Q><I><L><H><S><A><S><F><F><M><L><Y><L><V><T><L><M><G><N><I><L><I><V><T><V><T><T><C><D><S><S><L><H><M><P><M><Y><F><F><L><R><N><L><S><I><L><D><A><C><Y><I><S><V><T><V><P><T><S><C><V><N><S><L><L><D><S><T><T><I><S><K><A><G><C><V><A><Q><V><F><L><V><V><F><F><V><Y><V><E><L><L><F><L><T><I><M><A><H><D><R><Y><V><A><V><C><Q><P><L><H><Y><P><V><I><V><N><S><R><I><C><I><Q><M><T><L><A><S><L><L><S><G><L><V><Y><A><G><M><H><T><G><S><T><F><Q><L><P><F><C><R><S><N><V><I><H><Q><F><F><C><D><I><P><S><L><L><K><L><S><C><S><D><T><F><S><N><E><V><M><I><V><V><S><A><L><G><V><G><G><G><C><F><I><F><I><I><R><S><Y><I><H><I><F><S><T><V><L><G><F><P><R><G><A><D><R><T><K><A><F><S><T><C><I><P><H><I><L><V><V><S><V><F><L><S><S><C><S><S><V><Y><L><R><P><P><A><I><P><A><A><T><Q><D><L><I><L><S><G><F><Y><S><I><M><P><P><L><F><N><P><I><I><Y><S><L><R><N><K><Q><I><K><V><A><I><K><K><I><M><K><R><I><F><Y><S><E><N><V> | Odorant receptor.<BOP> | Q8NHC7 |
Q8NCW6 | GLT11_HUMAN | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11 | Homo | <M><G><S><V><T><V><R><Y><F><C><Y><G><C><L><F><T><S><A><T><W><T><V><L><L><F><V><Y><F><N><F><S><E><V><T><Q><P><L><K><N><V><P><V><K><G><S><G><P><H><G><P><S><P><K><K><F><Y><P><R><F><T><R><G><P><S><R><V><L><E><P><Q><F><K><A><N><K><I><D><D><V><I><D><S><R><V><E><D><P><E><E><G><H><L><K><F><S><S><E><L><G><M><I><F><N><E><R><D><Q><E><L><R><D><L><G><Y><Q><K><H><A><F><N><M><L><I><S><D><R><L><G><Y><H><R><D><V><P><D><T><R><N><A><A><C><K><E><K><F><Y><P><P><D><L><P><A><A><S><V><V><I><C><F><Y><N><E><A><F><S><A><L><L><R><T><V><H><S><V><I><D><R><T><P><A><H><L><L><H><E><I><I><L><V><D><D><D><S><D><F><D><D><L><K><G><E><L><D><E><Y><V><Q><K><Y><L><P><G><K><I><K><V><I><R><N><T><K><R><E><G><L><I><R><G><R><M><I><G><A><A><H><A><T><G><E><V><L><V><F><L><D><S><H><C><E><V><N><V><M><W><L><Q><P><L><L><A><A><I><R><E><D><R><H><T><V><V><C><P><V><I><D><I><I><S><A><D><T><L><A><Y><S><S><S><P><V><V><R><G><G><F><N><W><G><L><H><F><K><W><D><L><V><P><L><S><E><L><G><R><A><E><G><A><T><A><P><I><K><S><P><T><M><A><G><G><L><F><A><M><N><R><Q><Y><F><H><E><L><G><Q><Y><D><S><G><M><D><I><W><G><G><E><N><L><E><I><S><F><R><I><W><M><C><G><G><K><L><F><I><I><P><C><S><R><V><G><H><I><F><R><K><R><R><P><Y><G><S><P><E><G><Q><D><T><M><T><H><N><S><L><R><L><A><H><V><W><L><D><E><Y><K><E><Q><Y><F><S><L><R><P><D><L><K><T><K><S><Y><G><N><I><S><E><R><V><E><L><R><K><K><L><G><C><K><S><F><K><W><Y><L><D><N><V><Y><P><E><M><Q><I><S><G><S><H><A><K><P><Q><Q><P><I><F><V><N><R><G><P><K><R><P><K><V><L><Q><R><G><R><L><Y><H><L><Q><T><N><K><C><L><V><A><Q><G><R><P><S><Q><K><G><G><L><V><V><L><K><A><C><D><Y><S><D><P><N><Q><I><W><I><Y><N><E><E><H><E><L><V><L><N><S><L><L><C><L><D><M><S><E><T><R><S><S><D><P><P><R><L><M><K><C><H><G><S><G><G><S><Q><Q><W><T><F><G><K><N><N><R><L><Y><Q><V><S><V><G><Q><C><L><R><A><V><D><P><L><G><Q><K><G><S><V><A><M><A><I><C><D><G><S><S><S><Q><Q><W><H><L><E><G> | Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO).<BOP> | Q8NCW6 |
Q7Z6J6 | FRMD5_HUMAN | FERM domain-containing protein 5 | Homo | <M><L><S><R><L><M><S><G><S><S><R><S><L><E><R><E><Y><S><C><T><V><R><L><L><D><D><S><E><Y><T><C><T><I><Q><R><D><A><K><G><Q><Y><L><F><D><L><L><C><H><H><L><N><L><L><E><K><D><Y><F><G><I><R><F><V><D><P><D><K><Q><R><H><W><L><E><F><T><K><S><V><V><K><Q><L><R><S><Q><P><P><F><T><M><C><F><R><V><K><F><Y><P><A><D><P><A><A><L><K><E><E><I><T><R><Y><L><V><F><L><Q><I><K><R><D><L><Y><H><G><R><L><L><C><K><T><S><D><A><A><L><L><A><A><Y><I><L><Q><A><E><I><G><D><Y><D><S><G><K><H><P><E><G><Y><S><S><K><F><Q><F><F><P><K><H><S><E><K><L><E><R><K><I><A><E><I><H><K><T><E><L><S><G><Q><T><P><A><T><S><E><L><N><F><L><R><K><A><Q><T><L><E><T><Y><G><V><D><P><H><P><C><K><D><V><S><G><N><A><A><F><L><A><F><T><P><F><G><F><V><V><L><Q><G><N><K><R><V><H><F><I><K><W><N><E><V><T><K><L><K><F><E><G><K><T><F><Y><L><Y><V><S><Q><K><E><E><K><K><I><I><L><T><Y><F><A><P><T><P><E><A><C><K><H><L><W><K><C><G><I><E><N><Q><A><F><Y><K><L><E><K><S><S><Q><V><R><T><V><S><S><S><N><L><F><F><K><G><S><R><F><R><Y><S><G><R><V><A><K><E><V><M><E><S><S><A><K><I><K><R><E><P><P><E><I><H><R><A><G><M><V><P><S><R><S><C><P><S><I><T><H><G><P><R><L><S><S><V><P><R><T><R><R><R><A><V><H><I><S><I><M><E><G><L><E><S><L><R><D><S><A><H><S><T><P><V><R><S><T><S><H><G><D><T><F><L><P><H><V><R><S><S><R><T><D><S><N><E><R><V><A><V><I><A><D><E><A><Y><S><P><A><D><S><V><L><P><T><P><V><A><E><H><S><L><E><L><M><L><L><S><R><Q><I><N><G><A><T><C><S><I><E><E><E><K><E><S><E><A><S><T><P><T><A><T><E><V><E><A><L><G><G><E><L><R><A><L><C><Q><G><H><S><G><P><E><E><E><Q><V><N><K><F><V><L><S><V><L><R><L><L><L><V><T><M><G><L><L><F><V><L><L><L><L><L><I><I><L><T><E><S><D><L><D><I><A><F><F><R><D><I><R><Q><T><P><E><F><E><Q><F><H><Y><Q><Y><F><C><P><L><R><R><W><F><A><C><K><I><R><S><V><V><S><L><L><I><D><T> | May be involved in regulation of cell migration . May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation .<BOP> | Q7Z6J6 |
Q6UXB8 | PI16_HUMAN | PSP94-binding protein | Homo | <M><H><G><S><C><S><F><L><M><L><L><L><P><L><L><L><L><L><V><A><T><T><G><P><V><G><A><L><T><D><E><E><K><R><L><M><V><E><L><H><N><L><Y><R><A><Q><V><S><P><T><A><S><D><M><L><H><M><R><W><D><E><E><L><A><A><F><A><K><A><Y><A><R><Q><C><V><W><G><H><N><K><E><R><G><R><R><G><E><N><L><F><A><I><T><D><E><G><M><D><V><P><L><A><M><E><E><W><H><H><E><R><E><H><Y><N><L><S><A><A><T><C><S><P><G><Q><M><C><G><H><Y><T><Q><V><V><W><A><K><T><E><R><I><G><C><G><S><H><F><C><E><K><L><Q><G><V><E><E><T><N><I><E><L><L><V><C><N><Y><E><P><P><G><N><V><K><G><K><R><P><Y><Q><E><G><T><P><C><S><Q><C><P><S><G><Y><H><C><K><N><S><L><C><E><P><I><G><S><P><E><D><A><Q><D><L><P><Y><L><V><T><E><A><P><S><F><R><A><T><E><A><S><D><S><R><K><M><G><T><P><S><S><L><A><T><G><I><P><A><F><L><V><T><E><V><S><G><S><L><A><T><K><A><L><P><A><V><E><T><Q><A><P><T><S><L><A><T><K><D><P><P><S><M><A><T><E><A><P><P><C><V><T><T><E><V><P><S><I><L><A><A><H><S><L><P><S><L><D><E><E><P><V><T><F><P><K><S><T><H><V><P><I><P><K><S><A><D><K><V><T><D><K><T><K><V><P><S><R><S><P><E><N><S><L><D><P><K><M><S><L><T><G><A><R><E><L><L><P><H><A><Q><E><E><A><E><A><E><A><E><L><P><P><S><S><E><V><L><A><S><V><F><P><A><Q><D><K><P><G><E><L><Q><A><T><L><D><H><T><G><H><T><S><S><K><S><L><P><N><F><P><N><T><S><A><T><A><N><A><T><G><G><R><A><L><A><L><Q><S><S><L><P><G><A><E><G><P><D><K><P><S><V><V><S><G><L><N><S><G><P><G><H><V><W><G><P><L><L><G><L><L><L><L><P><P><L><V><L><A><G><I><F> | May inhibit cardiomyocyte growth.<BOP> | Q6UXB8 |
D3W0D1 | KLRF2_HUMAN | Activating coreceptor NKp65 | Homo | <M><E><N><E><D><G><Y><M><T><L><S><F><K><N><R><C><K><S><K><Q><K><S><K><D><F><S><L><Y><P><Q><Y><Y><C><L><L><L><I><F><G><C><I><V><I><L><I><F><I><M><T><G><I><D><L><K><F><W><H><K><K><M><D><F><S><Q><N><V><N><V><S><S><L><S><G><H><N><Y><L><C><P><N><D><W><L><L><N><E><G><K><C><Y><W><F><S><T><S><F><K><T><W><K><E><S><Q><R><D><C><T><Q><L><Q><A><H><L><L><V><I><Q><N><L><D><E><L><E><F><I><Q><N><S><L><K><P><G><H><F><G><W><I><G><L><Y><V><T><F><Q><G><N><L><W><M><W><I><D><E><H><F><L><V><P><E><L><F><S><V><I><G><P><T><D><D><R><S><C><A><V><I><T><G><N><W><V><Y><S><E><D><C><S><S><T><F><K><G><I><C><Q><R><D><A><I><L><T><H><N><G><T><S><G><V> | C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.<BOP> | D3W0D1 |
Q9NPR9 | GP108_HUMAN | Lung seven transmembrane receptor 2 | Homo | <M><A><V><S><E><R><R><G><L><G><R><G><S><P><A><E><W><G><Q><R><L><L><L><V><L><L><L><G><G><C><S><G><R><I><H><Q><L><A><L><T><G><E><K><R><A><D><I><Q><L><N><S><F><G><F><Y><T><N><G><S><L><E><V><E><L><S><V><L><R><L><G><L><R><E><A><E><E><K><S><L><L><V><G><F><S><L><S><R><V><R><S><G><R><V><R><S><Y><S><T><R><D><F><Q><D><C><P><L><Q><K><N><S><S><S><F><L><V><L><F><L><I><N><T><K><D><L><Q><V><Q><V><R><K><Y><G><E><Q><K><T><L><F><I><F><P><G><L><L><P><E><A><P><S><K><P><G><L><P><K><P><Q><A><T><V><P><R><K><V><D><G><G><G><T><S><A><A><S><K><P><K><S><T><P><A><V><I><Q><G><P><S><G><K><D><K><D><L><V><L><G><L><S><H><L><N><N><S><Y><N><F><S><F><H><V><V><I><G><S><Q><A><E><E><G><Q><Y><S><L><N><F><H><N><C><N><N><S><V><P><G><K><E><H><P><F><D><I><T><V><M><I><R><E><K><N><P><D><G><F><L><S><A><A><E><M><P><L><F><K><L><Y><M><V><M><S><A><C><F><L><A><A><G><I><F><W><V><S><I><L><C><R><N><T><Y><S><V><F><K><I><H><W><L><M><A><A><L><A><F><T><K><S><I><S><L><L><F><H><S><I><N><Y><Y><F><I><N><S><Q><G><H><P><I><E><G><L><A><V><M><Y><Y><I><A><H><L><L><K><G><A><L><L><F><I><T><I><A><L><I><G><S><G><W><A><F><I><K><Y><V><L><S><D><K><E><K><K><V><F><G><I><V><I><P><M><Q><V><L><A><N><V><A><Y><I><I><I><E><S><R><E><E><G><A><S><D><Y><V><L><W><K><E><I><L><F><L><V><D><L><I><C><C><G><A><I><L><F><P><V><V><W><S><I><R><H><L><Q><D><A><S><G><T><D><G><K><V><A><V><N><L><A><K><L><K><L><F><R><H><Y><Y><V><M><V><I><C><Y><V><Y><F><T><R><I><I><A><I><L><L><Q><V><A><V><P><F><Q><W><Q><W><L><Y><Q><L><L><V><E><G><S><T><L><A><F><F><V><L><T><G><Y><K><F><Q><P><T><G><N><N><P><Y><L><Q><L><P><Q><E><D><E><E><D><V><Q><M><E><Q><V><M><T><D><S><G><F><R><E><G><L><S><K><V><N><K><T><A><S><G><R><E><L><L> | (Microbial infection) Plays an essential function in adeno-associated virus (AAV) transduction across multiple serotypes except AAV5. May play a critical role in mediating the endosomal virus escape or in the AAV virions trafficking from endosomes to the nucleus.<BOP> | Q9NPR9 |
P25208 | NFYB_HUMAN | Nuclear transcription factor Y subunit B | Homo | <M><T><M><D><G><D><S><S><T><T><D><A><S><Q><L><G><I><S><A><D><Y><I><G><G><S><H><Y><V><I><Q><P><H><D><D><T><E><D><S><M><N><D><H><E><D><T><N><G><S><K><E><S><F><R><E><Q><D><I><Y><L><P><I><A><N><V><A><R><I><M><K><N><A><I><P><Q><T><G><K><I><A><K><D><A><K><E><C><V><Q><E><C><V><S><E><F><I><S><F><I><T><S><E><A><S><E><R><C><H><Q><E><K><R><K><T><I><N><G><E><D><I><L><F><A><M><S><T><L><G><F><D><S><Y><V><E><P><L><K><L><Y><L><Q><K><F><R><E><A><M><K><G><E><K><G><I><G><G><A><V><T><A><T><D><G><L><S><E><E><L><T><E><E><A><F><T><N><Q><L><P><A><G><L><I><T><T><D><G><Q><Q><Q><N><V><M><V><Y><T><T><S><Y><Q><Q><I><S><G><V><Q><Q><I><Q><F><S> | Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.<BOP> | P25208 |
P60372 | KR104_HUMAN | Keratin-associated protein 18.4 | Homo | <M><S><V><C><S><S><D><L><S><Y><S><S><R><V><C><L><P><G><S><C><D><S><C><S><D><S><W><Q><V><D><D><C><P><E><S><C><C><E><P><P><C><C><A><P><S><C><C><A><P><A><P><C><L><S><L><V><C><T><P><V><S><R><V><S><S><P><C><C><P><V><T><C><E><P><S><P><C><Q><S><G><C><T><S><S><C><T><P><S><C><C><Q><Q><S><S><C><Q><L><A><C><C><A><S><S><P><C><Q><Q><A><C><C><V><P><V><C><C><K><T><V><C><C><K><P><V><C><C><V><P><V><C><C><G><D><S><S><C><C><Q><Q><S><S><C><Q><S><A><C><C><T><S><S><P><C><Q><Q><A><C><C><V><P><I><C><C><K><P><V><C><S><G><I><S><S><S><C><C><Q><Q><S><S><C><V><S><C><V><S><S><P><C><C><Q><A><V><C><E><P><S><P><C><Q><S><G><C><I><S><S><C><T><P><S><C><C><Q><Q><S><S><C><Q><P><A><C><C><T><S><S><S><C><Q><Q><A><C><C><V><P><V><C><C><K><T><V><C><C><K><P><V><C><S><E><D><S><S><S><C><C><Q><Q><S><S><C><Q><P><A><C><C><T><S><S><P><C><Q><Q><A><C><C><V><P><V><C><C><K><P><V><C><C><K><P><V><G><S><V><P><I><C><S><G><A><S><S><L><C><C><Q><Q><S><S><C><Q><P><A><C><C><T><S><S><Q><S><Q><Q><G><C><C><V><P><V><C><C><K><P><V><S><C><V><P><V><C><S><G><A><S><S><S><C><C><Q><Q><S><S><C><Q><P><A><C><C><T><T><S><C><C><R><P><S><S><S><V><S><L><L><C><R><P><V><C><R><P><A><C><C><V><P><V><P><S><C><C><A><P><T><S><S><C><Q><P><S><C><C><R><P><A><S><C><V><S><L><L> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | P60372 |
Q9NPC2 | KCNK9_HUMAN | Two pore potassium channel KT3.2 | Homo | <M><K><R><Q><N><V><R><T><L><S><L><I><V><C><T><F><T><Y><L><L><V><G><A><A><V><F><D><A><L><E><S><D><H><E><M><R><E><E><E><K><L><K><A><E><E><I><R><I><K><G><K><Y><N><I><S><S><E><D><Y><R><Q><L><E><L><V><I><L><Q><S><E><P><H><R><A><G><V><Q><W><K><F><A><G><S><F><Y><F><A><I><T><V><I><T><T><I><G><Y><G><H><A><A><P><G><T><D><A><G><K><A><F><C><M><F><Y><A><V><L><G><I><P><L><T><L><V><M><F><Q><S><L><G><E><R><M><N><T><F><V><R><Y><L><L><K><R><I><K><K><C><C><G><M><R><N><T><D><V><S><M><E><N><M><V><T><V><G><F><F><S><C><M><G><T><L><C><I><G><A><A><A><F><S><Q><C><E><E><W><S><F><F><H><A><Y><Y><Y><C><F><I><T><L><T><T><I><G><F><G><D><Y><V><A><L><Q><T><K><G><A><L><Q><K><K><P><L><Y><V><A><F><S><F><M><Y><I><L><V><G><L><T><V><I><G><A><F><L><N><L><V><V><L><R><F><L><T><M><N><S><E><D><E><R><R><D><A><E><E><R><A><S><L><A><G><N><R><N><S><M><V><I><H><I><P><E><E><P><R><P><S><R><P><R><Y><K><A><D><V><P><D><L><Q><S><V><C><S><C><T><C><Y><R><S><Q><D><Y><G><G><R><S><V><A><P><Q><N><S><F><S><A><K><L><A><P><H><Y><F><H><S><I><S><Y><K><I><E><E><I><S><P><S><T><L><K><N><S><L><F><P><S><P><I><S><S><I><S><P><G><L><H><S><F><T><D><H><Q><R><L><M><K><R><R><K><S><V> | pH-dependent, voltage-insensitive, background potassium channel protein.<BOP> | Q9NPC2 |
Q9NPF7 | IL23A_HUMAN | Interleukin-23 subunit p19 | Homo | <M><L><G><S><R><A><V><M><L><L><L><L><L><P><W><T><A><Q><G><R><A><V><P><G><G><S><S><P><A><W><T><Q><C><Q><Q><L><S><Q><K><L><C><T><L><A><W><S><A><H><P><L><V><G><H><M><D><L><R><E><E><G><D><E><E><T><T><N><D><V><P><H><I><Q><C><G><D><G><C><D><P><Q><G><L><R><D><N><S><Q><F><C><L><Q><R><I><H><Q><G><L><I><F><Y><E><K><L><L><G><S><D><I><F><T><G><E><P><S><L><L><P><D><S><P><V><G><Q><L><H><A><S><L><L><G><L><S><Q><L><L><Q><P><E><G><H><H><W><E><T><Q><Q><I><P><S><L><S><P><S><Q><P><W><Q><R><L><L><L><R><F><K><I><L><R><S><L><Q><A><F><V><A><V><A><A><R><V><F><A><H><G><A><A><T><L><S><P> | Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity . Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 . This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A . In turn, participates in the early and effective intracellular bacterial clearance . Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells .<BOP> | Q9NPF7 |
Q8NE18 | NSUN7_HUMAN | NOL1/NOP2/Sun domain family member 7 | Homo | <M><L><N><S><T><G><E><L><E><F><S><N><E><E><D><P><E><I><I><S><Q><L><T><S><L><P><L><S><G><G><K><S><S><A><G><V><P><E><K><T><G><Y><P><D><S><V><Y><V><M><A><A><N><I><F><Q><G><I><R><I><E><K><S><A><Q><K><V><L><I><K><Y><G><N><E><P><L><R><S><L><S><E><S><E><D><Q><S><F><Q><R><L><S><Y><E><L><A><F><S><A><L><K><Y><Q><D><I><L><E><T><I><L><I><D><S><C><I><F><P><S><T><T><I><P><D><H><L><S><S><L><I><I><V><M><L><Y><D><F><Q><D><R><K><F><Q><T><R><V><L><S><D><N><E><E><P><I><S><E><V><Q><E><V><E><N><L><L><N><S><F><K><I><K><L><A><A><A><L><A><R><C><R><I><K><H><D><A><L><S><I><Y><H><I><L><P><E><T><V><R><K><Q><E><L><R><A><S><T><L><P><L><Y><A><W><I><N><T><C><K><I><S><P><E><E><V><Y><N><N><L><K><R><R><G><Y><N><K><V><K><S><V><L><H><I><D><D><K><V><F><A><V><D><Q><H><C><Y><D><V><L><I><F><P><S><H><L><K><N><D><L><I><N><I><D><L><F><K><D><Y><K><L><I><F><Q><D><K><S><R><S><L><A><V><H><S><V><K><A><L><L><N><M><D><D><D><V><L><M><V><N><T><G><S><W><Y><T><V><S><H><M><S><I><L><T><N><N><N><T><S><K><V><F><V><C><G><V><Q><S><Q><A><K><D><P><D><L><K><T><L><F><T><K><I><G><C><K><N><I><E><I><L><H><E><K><F><I><N><I><E><S><K><D><H><R><L><Q><K><V><K><V><I><L><L><L><P><R><C><S><G><L><G><V><S><N><P><V><E><F><I><L><N><E><H><E><D><T><E><F><L><K><D><H><S><Q><G><G><I><S><V><D><K><L><H><V><L><A><Q><Q><Q><Y><E><Q><L><T><H><A><M><K><F><T><K><A><Q><A><V><V><Y><C><T><C><S><V><F><P><E><E><N><E><A><V><V><K><K><A><L><E><F><Q><D><L><G><N><K><G><Q><P><Y><R><L><S><P><P><V><L><P><L><C><S><L><K><E><I><Q><L><S><T><D><K><F><F><R><M><E><P><S><E><I><T><N><G><C><F><L><S><I><L><T><R><E><R><D><P><S><E><T><V><S><V><N><D><V><L><A><R><A><A><A><K><G><L><L><D><G><I><E><L><G><K><S><S><K><R><E><K><K><K><K><K><S><K><T><S><L><T><K><G><A><T><T><D><N><G><I><Q><M><K><I><A><E><F><L><N><R><E><T><K><A><S><A><N><L><S><E><T><V><T><K><P><P><L><P><Q><K><N><T><A><Q><V><G><A><S><S><Q><T><R><K><P><N><K><L><A><P><H><P><A><V><P><A><F><V><K><N><T><C><P><S><R><P><R><E><R><Q><T><H><F><L><R><P><R><P><E><D><R><M><V><A><L><K><P><I><K><I><V><L><P><P><V><F><M><P><F><S><S><P><Q><G><I><R><S><R><M><P><T><Q><H><L><Y><C><R><W><V><A><P><K><A><L><V><P><T><C><L><P><T><H><S><L><S><R><K><E><E><K><P><K><D><D><T><P><S><S><L><L><R><P><P><R><R><W><L> | May have S-adenosyl-L-methionine-dependent methyl-transferase activity.<BOP> | Q8NE18 |
O43895 | XPP2_HUMAN | X-Pro aminopeptidase 2 | Homo | <M><A><R><A><H><W><G><C><C><P><W><L><V><L><L><C><A><C><A><W><G><H><T><K><P><V><D><L><G><G><Q><D><V><R><N><C><S><T><N><P><P><Y><L><P><V><T><V><V><N><T><T><M><S><L><T><A><L><R><Q><Q><M><Q><T><Q><N><L><S><A><Y><I><I><P><G><T><D><A><H><M><N><E><Y><I><G><Q><H><D><E><R><R><A><W><I><T><G><F><T><G><S><A><G><T><A><V><V><T><M><K><K><A><A><V><W><T><D><S><R><Y><W><T><Q><A><E><R><Q><M><D><C><N><W><E><L><H><K><E><V><G><T><T><P><I><V><T><W><L><L><T><E><I><P><A><G><G><R><V><G><F><D><P><F><L><L><S><I><D><T><W><E><S><Y><D><L><A><L><Q><G><S><N><R><Q><L><V><S><I><T><T><N><L><V><D><L><V><W><G><S><E><R><P><P><V><P><N><Q><P><I><Y><A><L><Q><E><A><F><T><G><S><T><W><Q><E><K><V><S><G><V><R><S><Q><M><Q><K><H><Q><K><V><P><T><A><V><L><L><S><A><L><E><E><T><A><W><L><F><N><L><R><A><S><D><I><P><Y><N><P><F><F><Y><S><Y><T><L><L><T><D><S><S><I><R><L><F><A><N><K><S><R><F><S><S><E><T><L><S><Y><L><N><S><S><C><T><G><P><M><C><V><Q><I><E><D><Y><S><Q><V><R><D><S><I><Q><A><Y><S><L><G><D><V><R><I><W><I><G><T><S><Y><T><M><Y><G><I><Y><E><M><I><P><K><E><K><L><V><T><D><T><Y><S><P><V><M><M><T><K><A><V><K><N><S><K><E><Q><A><L><L><K><A><S><H><V><R><D><A><V><A><V><I><R><Y><L><V><W><L><E><K><N><V><P><K><G><T><V><D><E><F><S><G><A><E><I><V><D><K><F><R><G><E><E><Q><F><S><S><G><P><S><F><E><T><I><S><A><S><G><L><N><A><A><L><A><H><Y><S><P><T><K><E><L><N><R><K><L><S><S><D><E><M><Y><L><L><D><S><G><G><Q><Y><W><D><G><T><T><D><I><T><R><T><V><H><W><G><T><P><S><A><F><Q><K><E><A><Y><T><R><V><L><I><G><N><I><D><L><S><R><L><I><F><P><A><A><T><S><G><R><M><V><E><A><F><A><R><R><A><L><W><D><A><G><L><N><Y><G><H><G><T><G><H><G><I><G><N><F><L><C><V><H><E><W><P><V><G><F><Q><S><N><N><I><A><M><A><K><G><M><F><T><S><I><E><P><G><Y><Y><K><D><G><E><F><G><I><R><L><E><D><V><A><L><V><V><E><A><K><T><K><Y><P><G><S><Y><L><T><F><E><V><V><S><F><V><P><Y><D><R><N><L><I><D><V><S><L><L><S><P><E><H><L><Q><Y><L><N><R><Y><Y><Q><T><I><R><E><K><V><G><P><E><L><Q><R><R><Q><L><L><E><E><F><E><W><L><Q><Q><H><T><E><P><L><A><A><R><A><P><D><T><A><S><W><A><S><V><L><V><V><S><T><L><A><I><L><G><W><S><V> | Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin.<BOP> | O43895 |
Q8NDN9 | RCBT1_HUMAN | Regulator of chromosome condensation and BTB domain-containing protein 1 | Homo | <M><V><D><V><G><K><W><P><I><F><T><L><L><S><P><Q><E><I><A><S><I><R><K><A><C><V><F><G><T><S><A><S><E><A><L><Y><V><T><D><N><D><E><V><F><V><F><G><L><N><Y><S><N><C><L><G><T><G><D><N><Q><S><T><L><V><P><K><K><L><E><G><L><C><G><K><K><I><K><S><L><S><Y><G><S><G><P><H><V><L><L><S><T><E><D><G><V><V><Y><A><W><G><H><N><G><Y><S><Q><L><G><N><G><T><T><N><Q><G><I><A><P><V><Q><V><C><T><N><L><L><I><K><Q><V><V><E><V><A><C><G><S><H><H><S><M><A><L><A><A><D><G><E><V><F><A><W><G><Y><N><N><C><G><Q><V><G><S><G><S><T><A><N><Q><P><T><P><R><K><V><T><N><C><L><H><I><K><R><V><V><G><I><A><C><G><Q><T><S><S><M><A><V><L><D><N><G><E><V><Y><G><W><G><Y><N><G><N><G><Q><L><G><L><G><N><N><G><N><Q><L><T><P><V><R><V><A><A><L><H><S><V><C><V><N><Q><I><V><C><G><Y><A><H><T><L><A><L><T><D><E><G><L><L><Y><A><W><G><A><N><T><Y><G><Q><L><G><T><G><N><K><N><N><L><L><S><P><A><H><I><M><V><E><K><E><R><V><V><E><I><A><A><C><H><S><A><H><T><S><A><A><K><T><Q><G><G><H><V><Y><M><W><G><Q><C><R><G><Q><S><V><I><L><P><H><L><T><H><F><S><C><T><D><D><V><F><A><C><F><A><T><P><A><V><S><W><R><L><L><S><V><E><H><E><D><F><L><T><V><A><E><S><L><K><K><E><F><D><S><P><E><T><A><D><L><K><F><R><I><D><G><K><Y><I><H><V><H><K><A><V><L><K><I><R><C><E><H><F><R><S><M><F><Q><S><Y><W><N><E><D><M><K><E><V><I><E><I><D><Q><F><S><Y><P><V><Y><R><A><F><L><Q><Y><L><Y><T><D><T><V><D><L><P><P><E><D><A><I><G><L><L><D><L><A><T><S><Y><C><E><N><R><L><K><K><L><C><Q><H><I><I><K><R><G><I><T><V><E><N><A><F><S><L><F><S><A><A><V><R><Y><D><A><E><D><L><E><E><F><C><F><K><F><C><I><N><H><L><T><E><V><T><Q><T><A><A><F><W><Q><M><D><G><P><L><L><K><E><F><I><A><K><A><S><K><C><G><A><F><K><N> | May be involved in cell cycle regulation by chromatin remodeling.<BOP> | Q8NDN9 |
Q8NGA1 | OR1M1_HUMAN | Olfactory receptor OR19-5 | Homo | <M><E><P><R><N><Q><T><S><A><S><Q><F><I><L><L><G><L><S><E><K><P><E><Q><E><T><L><L><F><S><L><F><F><C><M><Y><L><V><M><V><V><G><N><L><L><I><I><L><A><I><S><I><D><S><H><L><H><T><P><M><Y><F><F><L><A><N><L><S><L><V><D><F><C><L><A><T><N><T><I><P><K><M><L><V><S><L><Q><T><G><S><K><A><I><S><Y><P><C><C><L><I><Q><M><Y><F><F><H><F><F><G><I><V><D><S><V><I><I><A><M><M><A><Y><D><R><F><V><A><I><C><H><P><L><H><Y><A><K><I><M><S><L><R><L><C><R><L><L><V><G><A><L><W><A><F><S><C><F><I><S><L><T><H><I><L><L><M><A><R><L><V><F><C><G><S><H><E><V><P><H><Y><F><C><D><L><T><P><I><L><R><L><S><C><T><D><T><S><V><N><R><I><F><I><L><I><V><A><G><M><V><I><A><T><P><F><V><C><I><L><A><S><Y><A><R><I><L><V><A><I><M><K><V><P><S><A><G><G><R><K><K><A><F><S><T><C><S><S><H><L><S><V><V><A><L><F><Y><G><T><T><I><G><V><Y><L><C><P><S><S><V><L><T><T><V><K><E><K><A><S><A><V><M><Y><T><A><V><T><P><M><L><N><P><F><I><Y><S><L><R><N><R><D><L><K><G><A><L><R><K><L><V><N><R><K><I><T><S><S><S> | Odorant receptor.<BOP> | Q8NGA1 |
O75223 | GGCT_HUMAN | Cytochrome c-releasing factor 21 | Homo | <M><A><N><S><G><C><K><D><V><T><G><P><D><E><E><S><F><L><Y><F><A><Y><G><S><N><L><L><T><E><R><I><H><L><R><N><P><S><A><A><F><F><C><V><A><R><L><Q><D><F><K><L><D><F><G><N><S><Q><G><K><T><S><Q><T><W><H><G><G><I><A><T><I><F><Q><S><P><G><D><E><V><W><G><V><V><W><K><M><N><K><S><N><L><N><S><L><D><E><Q><E><G><V><K><S><G><M><Y><V><V><I><E><V><K><V><A><T><Q><E><G><K><E><I><T><C><R><S><Y><L><M><T><N><Y><E><S><A><P><P><S><P><Q><Y><K><K><I><I><C><M><G><A><K><E><N><G><L><P><L><E><Y><Q><E><K><L><K><A><I><E><P><N><D><Y><T><G><K><V><S><E><E><I><E><D><I><I><K><K><G><E><T><Q><T><L> | Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis . Induces release of cytochrome c from mitochondria with resultant induction of apoptosis .<BOP> | O75223 |
Q5TA31 | RN187_HUMAN | RING-type E3 ubiquitin transferase RNF187 | Homo | <M><A><L><P><A><G><P><A><E><A><A><C><A><L><C><Q><R><A><P><R><E><P><V><R><A><D><C><G><H><R><F><C><R><A><C><V><V><R><F><W><A><E><E><D><G><P><F><P><C><P><E><C><A><D><D><C><W><Q><R><A><V><E><P><G><R><P><P><L><S><R><R><L><L><A><L><E><E><A><A><A><A><P><A><R><D><G><P><A><S><E><A><A><L><Q><L><L><C><R><A><D><A><G><P><L><C><A><A><C><R><M><A><A><G><P><E><P><P><E><W><E><P><R><W><R><K><A><L><R><G><K><E><N><K><G><S><V><E><I><M><R><K><D><L><N><D><A><R><D><L><H><G><Q><A><E><S><A><A><A><V><W><K><G><H><V><M><D><R><R><K><K><A><L><T><D><Y><K><K><L><R><A><F><F><V><E><E><E><E><H><F><L><Q><E><A><E><K><E><E><G><L><P><E><D><E><L><A><D><P><T><E><R><F><R><S><L><L><Q><A><V><S><E><L><E><K><K><H><R><N><L><G><L><S><M><L><L><Q> | E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.<BOP> | Q5TA31 |
Q9NRX4 | PHP14_HUMAN | Protein janus-A homolog | Homo | <M><A><V><A><D><L><A><L><I><P><D><V><D><I><D><S><D><G><V><F><K><Y><V><L><I><R><V><H><S><A><P><R><S><G><A><P><A><A><E><S><K><E><I><V><R><G><Y><K><W><A><E><Y><H><A><D><I><Y><D><K><V><S><G><D><M><Q><K><Q><G><C><D><C><E><C><L><G><G><G><R><I><S><H><Q><S><Q><D><K><K><I><H><V><Y><G><Y><S><M><A><Y><G><P><A><Q><H><A><I><S><T><E><K><I><K><A><K><Y><P><D><Y><E><V><T><W><A><N><D><G><Y> | Exhibits phosphohistidine phosphatase activity.<BOP> | Q9NRX4 |
O60609 | GFRA3_HUMAN | GDNF family receptor alpha-3 | Homo | <M><V><R><P><L><N><P><R><P><L><P><P><V><V><L><M><L><L><L><L><L><P><P><S><P><L><P><L><A><A><G><D><P><L><P><T><E><S><R><L><M><N><S><C><L><Q><A><R><R><K><C><Q><A><D><P><T><C><S><A><A><Y><H><H><L><D><S><C><T><S><S><I><S><T><P><L><P><S><E><E><P><S><V><P><A><D><C><L><E><A><A><Q><Q><L><R><N><S><S><L><I><G><C><M><C><H><R><R><M><K><N><Q><V><A><C><L><D><I><Y><W><T><V><H><R><A><R><S><L><G><N><Y><E><L><D><V><S><P><Y><E><D><T><V><T><S><K><P><W><K><M><N><L><S><K><L><N><M><L><K><P><D><S><D><L><C><L><K><F><A><M><L><C><T><L><N><D><K><C><D><R><L><R><K><A><Y><G><E><A><C><S><G><P><H><C><Q><R><H><V><C><L><R><Q><L><L><T><F><F><E><K><A><A><E><P><H><A><Q><G><L><L><L><C><P><C><A><P><N><D><R><G><C><G><E><R><R><R><N><T><I><A><P><N><C><A><L><P><P><V><A><P><N><C><L><E><L><R><R><L><C><F><S><D><P><L><C><R><S><R><L><V><D><F><Q><T><H><C><H><P><M><D><I><L><G><T><C><A><T><E><Q><S><R><C><L><R><A><Y><L><G><L><I><G><T><A><M><T><P><N><F><V><S><N><V><N><T><S><V><A><L><S><C><T><C><R><G><S><G><N><L><Q><E><E><C><E><M><L><E><G><F><F><S><H><N><P><C><L><T><E><A><I><A><A><K><M><R><F><H><S><Q><L><F><S><Q><D><W><P><H><P><T><F><A><V><M><A><H><Q><N><E><N><P><A><V><R><P><Q><P><W><V><P><S><L><F><S><C><T><L><P><L><I><L><L><L><S><L><W> | Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.<BOP> | O60609 |
P01591 | IGJ_HUMAN | Joining chain of multimeric IgA and IgM | Homo | <M><K><N><H><L><L><F><W><G><V><L><A><V><F><I><K><A><V><H><V><K><A><Q><E><D><E><R><I><V><L><V><D><N><K><C><K><C><A><R><I><T><S><R><I><I><R><S><S><E><D><P><N><E><D><I><V><E><R><N><I><R><I><I><V><P><L><N><N><R><E><N><I><S><D><P><T><S><P><L><R><T><R><F><V><Y><H><L><S><D><L><C><K><K><C><D><P><T><E><V><E><L><D><N><Q><I><V><T><A><T><Q><S><N><I><C><D><E><D><S><A><T><E><T><C><Y><T><Y><D><R><N><K><C><Y><T><A><V><V><P><L><V><Y><G><G><E><T><K><M><V><E><T><A><L><T><P><D><A><C><Y><P><D> | Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component.<BOP> | P01591 |
Q9Y646 | CBPQ_HUMAN | Plasma glutamate carboxypeptidase | Homo | <M><K><F><L><I><F><A><F><F><G><G><V><H><L><L><S><L><C><S><G><K><A><I><C><K><N><G><I><S><K><R><T><F><E><E><I><K><E><E><I><A><S><C><G><D><V><A><K><A><I><I><N><L><A><V><Y><G><K><A><Q><N><R><S><Y><E><R><L><A><L><L><V><D><T><V><G><P><R><L><S><G><S><K><N><L><E><K><A><I><Q><I><M><Y><Q><N><L><Q><Q><D><G><L><E><K><V><H><L><E><P><V><R><I><P><H><W><E><R><G><E><E><S><A><V><M><L><E><P><R><I><H><K><I><A><I><L><G><L><G><S><S><I><G><T><P><P><E><G><I><T><A><E><V><L><V><V><T><S><F><D><E><L><Q><R><R><A><S><E><A><R><G><K><I><V><V><Y><N><Q><P><Y><I><N><Y><S><R><T><V><Q><Y><R><T><Q><G><A><V><E><A><A><K><V><G><A><L><A><S><L><I><R><S><V><A><S><F><S><I><Y><S><P><H><T><G><I><Q><E><Y><Q><D><G><V><P><K><I><P><T><A><C><I><T><V><E><D><A><E><M><M><S><R><M><A><S><H><G><I><K><I><V><I><Q><L><K><M><G><A><K><T><Y><P><D><T><D><S><F><N><T><V><A><E><I><T><G><S><K><Y><P><E><Q><V><V><L><V><S><G><H><L><D><S><W><D><V><G><Q><G><A><M><D><D><G><G><G><A><F><I><S><W><E><A><L><S><L><I><K><D><L><G><L><R><P><K><R><T><L><R><L><V><L><W><T><A><E><E><Q><G><G><V><G><A><F><Q><Y><Y><Q><L><H><K><V><N><I><S><N><Y><S><L><V><M><E><S><D><A><G><T><F><L><P><T><G><L><Q><F><T><G><S><E><K><A><R><A><I><M><E><E><V><M><S><L><L><Q><P><L><N><I><T><Q><V><L><S><H><G><E><G><T><D><I><N><F><W><I><Q><A><G><V><P><G><A><S><L><L><D><D><L><Y><K><Y><F><F><F><H><H><S><H><G><D><T><M><T><V><M><D><P><K><Q><M><N><V><A><A><A><V><W><A><V><V><S><Y><V><V><A><D><M><E><E><M><L><P><R><S> | Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.<BOP> | Q9Y646 |
Q99965 | ADAM2_HUMAN | PH30-beta | Homo | <M><W><R><V><L><F><L><L><S><G><L><G><G><L><R><M><D><S><N><F><D><S><L><P><V><Q><I><T><V><P><E><K><I><R><S><I><I><K><E><G><I><E><S><Q><A><S><Y><K><I><V><I><E><G><K><P><Y><T><V><N><L><M><Q><K><N><F><L><P><H><N><F><R><V><Y><S><Y><S><G><T><G><I><M><K><P><L><D><Q><D><F><Q><N><F><C><H><Y><Q><G><Y><I><E><G><Y><P><K><S><V><V><M><V><S><T><C><T><G><L><R><G><V><L><Q><F><E><N><V><S><Y><G><I><E><P><L><E><S><S><V><G><F><E><H><V><I><Y><Q><V><K><H><K><K><A><D><V><S><L><Y><N><E><K><D><I><E><S><R><D><L><S><F><K><L><Q><S><V><E><P><Q><Q><D><F><A><K><Y><I><E><M><H><V><I><V><E><K><Q><L><Y><N><H><M><G><S><D><T><T><V><V><A><Q><K><V><F><Q><L><I><G><L><T><N><A><I><F><V><S><F><N><I><T><I><I><L><S><S><L><E><L><W><I><D><E><N><K><I><A><T><T><G><E><A><N><E><L><L><H><T><F><L><R><W><K><T><S><Y><L><V><L><R><P><H><D><V><A><F><L><L><V><Y><R><E><K><S><N><Y><V><G><A><T><F><Q><G><K><M><C><D><A><N><Y><A><G><G><V><V><L><H><P><R><T><I><S><L><E><S><L><A><V><I><L><A><Q><L><L><S><L><S><M><G><I><T><Y><D><D><I><N><K><C><Q><C><S><G><A><V><C><I><M><N><P><E><A><I><H><F><S><G><V><K><I><F><S><N><C><S><F><E><D><F><A><H><F><I><S><K><Q><K><S><Q><C><L><H><N><Q><P><R><L><D><P><F><F><K><Q><Q><A><V><C><G><N><A><K><L><E><A><G><E><E><C><D><C><G><T><E><Q><D><C><A><L><I><G><E><T><C><C><D><I><A><T><C><R><F><K><A><G><S><N><C><A><E><G><P><C><C><E><N><C><L><F><M><S><K><E><R><M><C><R><P><S><F><E><E><C><D><L><P><E><Y><C><N><G><S><S><A><S><C><P><E><N><H><Y><V><Q><T><G><H><P><C><G><L><N><Q><W><I><C><I><D><G><V><C><M><S><G><D><K><Q><C><T><D><T><F><G><K><E><V><E><F><G><P><S><E><C><Y><S><H><L><N><S><K><T><D><V><S><G><N><C><G><I><S><D><S><G><Y><T><Q><C><E><A><D><N><L><Q><C><G><K><L><I><C><K><Y><V><G><K><F><L><L><Q><I><P><R><A><T><I><I><Y><A><N><I><S><G><H><L><C><I><A><V><E><F><A><S><D><H><A><D><S><Q><K><M><W><I><K><D><G><T><S><C><G><S><N><K><V><C><R><N><Q><R><C><V><S><S><S><Y><L><G><Y><D><C><T><T><D><K><C><N><D><R><G><V><C><N><N><K><K><H><C><H><C><S><A><S><Y><L><P><P><D><C><S><V><Q><S><D><L><W><P><G><G><S><I><D><S><G><N><F><P><P><V><A><I><P><A><R><L><P><E><R><R><Y><I><E><N><I><Y><H><S><K><P><M><R><W><P><F><F><L><F><I><P><F><F><I><I><F><C><V><L><I><A><I><M><V><K><V><N><F><Q><R><K><K><W><R><T><E><D><Y><S><S><D><E><Q><P><E><S><E><S><E><P><K><G> | Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.<BOP> | Q99965 |
P07315 | CRGC_HUMAN | Gamma-crystallin 3 | Homo | <M><G><K><I><T><F><Y><E><D><R><A><F><Q><G><R><S><Y><E><T><T><T><D><C><P><N><L><Q><P><Y><F><S><R><C><N><S><I><R><V><E><S><G><C><W><M><L><Y><E><R><P><N><Y><Q><G><Q><Q><Y><L><L><R><R><G><E><Y><P><D><Y><Q><Q><W><M><G><L><S><D><S><I><R><S><C><C><L><I><P><Q><T><V><S><H><R><L><R><L><Y><E><R><E><D><H><K><G><L><M><M><E><L><S><E><D><C><P><S><I><Q><D><R><F><H><L><S><E><I><R><S><L><H><V><L><E><G><C><W><V><L><Y><E><L><P><N><Y><R><G><R><Q><Y><L><L><R><P><Q><E><Y><R><R><C><Q><D><W><G><A><M><D><A><K><A><G><S><L><R><R><V><V><D><L><Y> | Crystallins are the dominant structural components of the vertebrate eye lens.<BOP> | P07315 |
Q9H7C9 | AAMDC_HUMAN | Adipogenesis associated Mth938 domain-containing protein | Homo | <M><T><S><P><E><I><A><S><L><S><W><G><Q><M><K><V><K><G><S><N><T><T><Y><K><D><C><K><V><W><P><G><G><S><R><T><W><D><W><R><E><T><G><T><E><H><S><P><G><V><Q><P><A><D><V><K><E><V><V><E><K><G><V><Q><T><L><V><I><G><R><G><M><S><E><A><L><K><V><P><S><S><T><V><E><Y><L><K><K><H><G><I><D><V><R><V><L><Q><T><E><Q><A><V><K><E><Y><N><A><L><V><A><Q><G><V><R><V><G><G><V><F><H><S><T><C> | May play a role in preadipocyte differentiation and adipogenesis.<BOP> | Q9H7C9 |
O43296 | ZN264_HUMAN | Zinc finger protein 264 | Homo | <M><A><A><A><V><L><T><D><R><A><Q><V><S><V><T><F><D><D><V><A><V><T><F><T><K><E><E><W><G><Q><L><D><L><A><Q><R><T><L><Y><Q><E><V><M><L><E><N><C><G><L><L><V><S><L><G><C><P><V><P><K><A><E><L><I><C><H><L><E><H><G><Q><E><P><W><T><R><K><E><D><L><S><Q><D><T><C><P><G><D><K><G><K><P><K><T><T><E><P><T><T><C><E><P><A><L><S><E><G><I><S><L><Q><G><Q><V><T><Q><G><N><S><V><D><S><Q><L><G><Q><A><E><D><Q><D><G><L><S><E><M><Q><E><G><H><F><R><P><G><I><D><P><Q><E><K><S><P><G><K><M><S><P><E><C><D><G><L><G><T><A><D><G><V><C><S><R><I><G><Q><E><Q><V><S><P><G><D><R><V><R><S><H><N><S><C><E><S><G><K><D><P><M><I><Q><E><E><E><N><N><F><K><C><S><E><C><G><K><V><F><N><K><K><H><L><L><A><G><H><E><K><I><H><S><G><V><K><P><Y><E><C><T><E><C><G><K><T><F><I><K><S><T><H><L><L><Q><H><H><M><I><H><T><G><E><R><P><Y><E><C><M><E><C><G><K><A><F><N><R><K><S><Y><L><T><Q><H><Q><R><I><H><S><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><T><H><R><S><N><F><V><L><H><N><R><R><H><T><G><E><K><S><F><V><C><T><E><C><G><Q><V><F><R><H><R><P><G><F><L><R><H><Y><V><V><H><S><G><E><N><P><Y><E><C><L><E><C><G><K><V><F><K><H><R><S><Y><L><M><W><H><Q><Q><T><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><V><F><L><E><S><A><A><L><I><H><H><Y><V><I><H><T><G><E><K><P><F><E><C><L><E><C><G><K><A><F><N><H><R><S><Y><L><K><R><H><Q><R><I><H><T><G><E><K><P><F><V><C><S><E><C><G><K><A><F><T><H><C><S><T><F><I><L><H><K><R><A><H><T><G><E><K><P><F><E><C><K><E><C><G><K><A><F><S><N><R><K><D><L><I><R><H><F><S><I><H><T><G><E><K><P><Y><E><C><V><E><C><G><K><A><F><T><R><M><S><G><L><T><R><H><K><R><I><H><S><G><E><K><P><Y><E><C><V><E><C><G><K><S><F><C><W><S><T><N><L><I><R><H><A><I><I><H><T><G><E><K><P><Y><K><C><S><E><C><G><K><A><F><S><R><S><S><S><L><T><Q><H><Q><R><M><H><T><G><K><N><P><I><S><V><T><D><V><G><R><P><F><T><S><G><Q><T><S><V><T><L><R><E><L><L><L><G><K><D><F><L><N><V><T><T><E><A><N><I><L><P><E><E><T><S><S><S><A><S><D><Q><P><Y><Q><R><E><T><P><Q><V><S><S><L> | May be involved in transcriptional regulation.<BOP> | O43296 |
P0DMW2 | PYDC4_HUMAN | Pyrin-only protein 4 | Homo | <M><V><S><S><A><Q><L><D><F><N><L><Q><A><L><L><G><Q><L><S><Q><D><D><L><C><K><F><K><S><L><I><R><T><V><S><L><G><N><E><L><Q><K><I><P><Q><T> | May function as a negative regulator of NF-kappa-B by preventing RELA/p65 phosphorylation at 'Ser-536', thereby inhibiting its transcriptional activity. Through NF-kappa-B regulation may control cytokine release upon Toll-like receptors activation and therefore play a role in modulation of innate immunity. May also play a role in cell cycle progression and apoptotic process.<BOP> | P0DMW2 |
Q8WY22 | BRI3B_HUMAN | HCCRBP-1 | Homo | <M><G><A><R><A><S><G><G><P><L><A><R><A><G><L><L><L><L><L><L><L><L><L><L><L><G><L><L><A><P><G><A><Q><G><A><R><G><R><G><G><A><E><K><N><S><Y><R><R><T><V><N><T><F><S><Q><S><V><S><S><L><F><G><E><D><N><V><R><A><A><Q><K><F><L><A><R><L><T><E><R><F><V><L><G><V><D><M><F><V><E><T><L><W><K><V><W><T><E><L><L><D><V><L><G><L><D><V><S><N><L><S><Q><Y><F><S><P><A><S><V><S><S><S><P><A><R><A><L><L><L><V><G><V><V><L><L><A><Y><W><F><L><S><L><T><L><G><F><T><F><S><V><L><H><V><V><F><G><R><F><F><W><I><V><R><V><V><L><F><S><M><S><C><V><Y><I><L><H><K><Y><E><G><E><P><E><N><A><V><L><P><L><C><F><V><V><A><V><Y><F><M><T><G><P><M><G><F><Y><W><R><S><S><P><S><G><P><S><N><P><S><N><P><S><V><E><E><K><L><E><H><L><E><K><Q><V><R><L><L><N><I><R><L><N><R><V><L><E><S><L><D><R><S><K><D><K> | Involved in tumorigenesis and may function by stabilizing p53/TP53.<BOP> | Q8WY22 |
P13747 | HLAE_HUMAN | Soluble HLA class I histocompatibility antigen, alpha chain E | Homo | <M><V><D><G><T><L><L><L><L><L><S><E><A><L><A><L><T><Q><T><W><A><G><S><H><S><L><K><Y><F><H><T><S><V><S><R><P><G><R><G><E><P><R><F><I><S><V><G><Y><V><D><D><T><Q><F><V><R><F><D><N><D><A><A><S><P><R><M><V><P><R><A><P><W><M><E><Q><E><G><S><E><Y><W><D><R><E><T><R><S><A><R><D><T><A><Q><I><F><R><V><N><L><R><T><L><R><G><Y><Y><N><Q><S><E><A><G><S><H><T><L><Q><W><M><H><G><C><E><L><G><P><D><G><R><F><L><R><G><Y><E><Q><F><A><Y><D><G><K><D><Y><L><T><L><N><E><D><L><R><S><W><T><A><V><D><T><A><A><Q><I><S><E><Q><K><S><N><D><A><S><E><A><E><H><Q><R><A><Y><L><E><D><T><C><V><E><W><L><H><K><Y><L><E><K><G><K><E><T><L><L><H><L><E><P><P><K><T><H><V><T><H><H><P><I><S><D><H><E><A><T><L><R><C><W><A><L><G><F><Y><P><A><E><I><T><L><T><W><Q><Q><D><G><E><G><H><T><Q><D><T><E><L><V><E><T><R><P><A><G><D><G><T><F><Q><K><W><A><A><V><V><V><P><S><G><E><E><Q><R><Y><T><C><H><V><Q><H><E><G><L><P><E><P><V><T><L><R><W><K><P><A><S><Q><P><T><I><P><I><V><G><I><I><A><G><L><V><L><L><G><S><V><V><S><G><A><V><V><A><A><V><I><W><R><K><K><S><S><G><G><K><G><G><S><Y><S><K><A><E><W><S><D><S><A><Q><G><S><E><S><H><S><L> | (Microbial infection) Upon SARS-CoV-2 infection, may contribute to functional exhaustion of cytotoxic NK cells and CD8-positive T cells . Binds SARS-CoV-2 S/Spike protein S1-derived peptide (LQPRTFLL) expressed on the surface of lung epithelial cells, inducing NK cell exhaustion and dampening antiviral immune surveillance .<BOP> | P13747 |
Q9Y225 | RNF24_HUMAN | RING finger protein 24 | Homo | <M><S><S><D><F><P><H><Y><N><F><R><M><P><N><I><G><F><Q><N><L><P><L><N><I><Y><I><V><V><F><G><T><A><I><F><V><F><I><L><S><L><L><F><C><C><Y><L><I><R><L><R><H><Q><A><H><K><E><F><Y><A><Y><K><Q><V><I><L><K><E><K><V><K><E><L><N><L><H><E><L><C><A><V><C><L><E><D><F><K><P><R><D><E><L><G><I><C><P><C><K><H><A><F><H><R><K><C><L><I><K><W><L><E><V><R><K><V><C><P><L><C><N><M><P><V><L><Q><L><A><Q><L><H><S><K><Q><D><R><G><P><P><Q><G><P><L><P><G><A><E><N><I><V> | May play a role in TRPCs intracellular trafficking.<BOP> | Q9Y225 |
Q9NX76 | CKLF6_HUMAN | Chemokine-like factor superfamily member 6 | Homo | <M><E><N><G><A><V><Y><S><P><T><T><E><E><D><P><G><P><A><R><G><P><R><S><G><L><A><A><Y><F><F><M><G><R><L><P><L><L><R><R><V><L><K><G><L><Q><L><L><L><S><L><L><A><F><I><C><E><E><V><V><S><Q><C><T><L><C><G><G><L><Y><F><F><E><F><V><S><C><S><A><F><L><L><S><L><L><I><L><I><V><Y><C><T><P><F><Y><E><R><V><D><T><T><K><V><K><S><S><D><F><Y><I><T><L><G><T><G><C><V><F><L><L><A><S><I><I><F><V><S><T><H><D><R><T><S><A><E><I><A><A><I><V><F><G><F><I><A><S><F><M><F><L><L><D><F><I><T><M><L><Y><E><K><R><Q><E><S><Q><L><R><K><P><E><N><T><T><R><A><E><A><L><T><E><P><L><N><A> | Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.<BOP> | Q9NX76 |
P78410 | BT3A2_HUMAN | Butyrophilin subfamily 3 member A2 | Homo | <M><K><M><A><S><S><L><A><F><L><L><L><N><F><H><V><S><L><L><L><V><Q><L><L><T><P><C><S><A><Q><F><S><V><L><G><P><S><G><P><I><L><A><M><V><G><E><D><A><D><L><P><C><H><L><F><P><T><M><S><A><E><T><M><E><L><K><W><V><S><S><S><L><R><Q><V><V><N><V><Y><A><D><G><K><E><V><E><D><R><Q><S><A><P><Y><R><G><R><T><S><I><L><R><D><G><I><T><A><G><K><A><A><L><R><I><H><N><V><T><A><S><D><S><G><K><Y><L><C><Y><F><Q><D><G><D><F><Y><E><K><A><L><V><E><L><K><V><A><A><L><G><S><N><L><H><V><E><V><K><G><Y><E><D><G><G><I><H><L><E><C><R><S><T><G><W><Y><P><Q><P><Q><I><Q><W><S><N><A><K><G><E><N><I><P><A><V><E><A><P><V><V><A><D><G><V><G><L><Y><E><V><A><A><S><V><I><M><R><G><G><S><G><E><G><V><S><C><I><I><R><N><S><L><L><G><L><E><K><T><A><S><I><S><I><A><D><P><F><F><R><S><A><Q><P><W><I><A><A><L><A><G><T><L><P><I><L><L><L><L><L><A><G><A><S><Y><F><L><W><R><Q><Q><K><E><I><T><A><L><S><S><E><I><E><S><E><Q><E><M><K><E><M><G><Y><A><A><T><E><R><E><I><S><L><R><E><S><L><Q><E><E><L><K><R><K><K><I><Q><Y><L><T><R><G><E><E><S><S><S><D><T><N><K><S><A> | Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.<BOP> | P78410 |
Q8TF74 | WIPF2_HUMAN | WIP-related protein | Homo | <M><P><I><P><P><P><P><P><P><P><P><G><P><P><P><P><P><T><F><H><Q><A><N><T><E><Q><P><K><L><S><R><D><E><Q><R><G><R><G><A><L><L><Q><D><I><C><K><G><T><K><L><K><K><V><T><N><I><N><D><R><S><A><P><I><L><E><K><P><K><G><S><S><G><G><Y><G><S><G><G><A><A><L><Q><P><K><G><G><L><F><Q><G><G><V><L><K><L><R><P><V><G><A><K><D><G><S><E><N><L><A><G><K><P><A><L><Q><I><P><S><S><R><A><A><A><P><R><P><P><V><S><A><A><S><G><R><P><Q><D><D><T><D><S><S><R><A><S><L><P><E><L><P><R><M><Q><R><P><S><L><P><D><L><S><R><P><N><T><T><S><S><T><G><M><K><H><S><S><S><A><P><P><P><P><P><P><G><R><R><A><N><A><P><P><T><P><L><P><M><H><S><S><K><A><P><A><Y><N><R><E><K><P><L><P><P><T><P><G><Q><R><L><H><P><G><R><E><G><P><P><A><P><P><P><V><K><P><P><P><S><P><V><N><I><R><T><G><P><S><G><Q><S><L><A><P><P><P><P><P><Y><R><Q><P><P><G><V><P><N><G><P><S><S><P><T><N><E><S><A><P><E><L><P><Q><R><H><N><S><L><H><R><K><T><P><G><P><V><R><G><L><A><P><P><P><P><T><S><A><S><P><S><L><L><S><N><R><P><P><P><P><A><R><D><P><P><S><R><G><A><A><P><P><P><P><P><P><V><I><R><N><G><A><R><D><A><P><P><P><P><P><P><Y><R><M><H><G><S><E><P><P><S><R><G><K><P><P><P><P><P><S><R><T><P><A><G><P><P><P><P><P><P><P><P><L><R><N><G><H><R><D><S><I><T><T><V><R><S><F><L><D><D><F><E><S><K><Y><S><F><H><P><V><E><D><F><P><A><P><E><E><Y><K><H><F><Q><R><I><Y><P><S><K><T><N><R><A><A><R><G><A><P><P><L><P><P><I><L><R> | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.<BOP> | Q8TF74 |
Q9UBX7 | KLK11_HUMAN | Kallikrein-11 inactive chain 2 | Homo | <M><Q><R><L><R><W><L><R><D><W><K><S><S><G><R><G><L><T><A><A><K><E><P><G><A><R><S><S><P><L><Q><A><M><R><I><L><Q><L><I><L><L><A><L><A><T><G><L><V><G><G><E><T><R><I><I><K><G><F><E><C><K><P><H><S><Q><P><W><Q><A><A><L><F><E><K><T><R><L><L><C><G><A><T><L><I><A><P><R><W><L><L><T><A><A><H><C><L><K><P><R><Y><I><V><H><L><G><Q><H><N><L><Q><K><E><E><G><C><E><Q><T><R><T><A><T><E><S><F><P><H><P><G><F><N><N><S><L><P><N><K><D><H><R><N><D><I><M><L><V><K><M><A><S><P><V><S><I><T><W><A><V><R><P><L><T><L><S><S><R><C><V><T><A><G><T><S><C><L><I><S><G><W><G><S><T><S><S><P><Q><L><R><L><P><H><T><L><R><C><A><N><I><T><I><I><E><H><Q><K><C><E><N><A><Y><P><G><N><I><T><D><T><M><V><C><A><S><V><Q><E><G><G><K><D><S><C><Q><G><D><S><G><G><P><L><V><C><N><Q><S><L><Q><G><I><I><S><W><G><Q><D><P><C><A><I><T><R><K><P><G><V><Y><T><K><V><C><K><Y><V><D><W><I><Q><E><T><M><K><N><N> | Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.<BOP> | Q9UBX7 |
O43613 | OX1R_HUMAN | Orexin receptor type 1 | Homo | <M><E><P><S><A><T><P><G><A><Q><M><G><V><P><P><G><S><R><E><P><S><P><V><P><P><D><Y><E><D><E><F><L><R><Y><L><W><R><D><Y><L><Y><P><K><Q><Y><E><W><V><L><I><A><A><Y><V><A><V><F><V><V><A><L><V><G><N><T><L><V><C><L><A><V><W><R><N><H><H><M><R><T><V><T><N><Y><F><I><V><N><L><S><L><A><D><V><L><V><T><A><I><C><L><P><A><S><L><L><V><D><I><T><E><S><W><L><F><G><H><A><L><C><K><V><I><P><Y><L><Q><A><V><S><V><S><V><A><V><L><T><L><S><F><I><A><L><D><R><W><Y><A><I><C><H><P><L><L><F><K><S><T><A><R><R><A><R><G><S><I><L><G><I><W><A><V><S><L><A><I><M><V><P><Q><A><A><V><M><E><C><S><S><V><L><P><E><L><A><N><R><T><R><L><F><S><V><C><D><E><R><W><A><D><D><L><Y><P><K><I><Y><H><S><C><F><F><I><V><T><Y><L><A><P><L><G><L><M><A><M><A><Y><F><Q><I><F><R><K><L><W><G><R><Q><I><P><G><T><T><S><A><L><V><R><N><W><K><R><P><S><D><Q><L><G><D><L><E><Q><G><L><S><G><E><P><Q><P><R><A><R><A><F><L><A><E><V><K><Q><M><R><A><R><R><K><T><A><K><M><L><M><V><V><L><L><V><F><A><L><C><Y><L><P><I><S><V><L><N><V><L><K><R><V><F><G><M><F><R><Q><A><S><D><R><E><A><V><Y><A><C><F><T><F><S><H><W><L><V><Y><A><N><S><A><A><N><P><I><I><Y><N><F><L><S><G><K><F><R><E><Q><F><K><A><A><F><S><C><C><L><P><G><L><G><P><C><G><S><L><K><A><P><S><P><R><S><S><A><S><H><K><S><L><S><L><Q><S><R><C><S><I><S><K><I><S><E><H><V><V><L><T><S><V><T><T><V><L><P> | Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide . Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding .<BOP> | O43613 |
Q96A98 | TIP39_HUMAN | Parathyroid hormone 2 | Homo | <M><E><T><R><Q><V><S><R><S><P><R><V><R><L><L><L><L><L><L><L><L><L><V><V><P><W><G><V><R><T><A><S><G><V><A><L><P><P><V><G><V><L><S><L><R><P><P><G><R><A><W><A><D><P><A><T><P><R><P><R><R><S><L><A><L><A><D><D><A><A><F><R><E><R><A><R><L><L><A><A><L><E><R><R><H><W><L><N><S><Y><M><H><K><L><L><V><L><D><A><P> | Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.<BOP> | Q96A98 |
P31323 | KAP3_HUMAN | cAMP-dependent protein kinase type II-beta regulatory subunit | Homo | <M><S><I><E><I><P><A><G><L><T><E><L><L><Q><G><F><T><V><E><V><L><R><H><Q><P><A><D><L><L><E><F><A><L><Q><H><F><T><R><L><Q><Q><E><N><E><R><K><G><T><A><R><F><G><H><E><G><R><T><W><G><D><L><G><A><A><A><G><G><G><T><P><S><K><G><V><N><F><A><E><E><P><M><Q><S><D><S><E><D><G><E><E><E><E><A><A><P><A><D><A><G><A><F><N><A><P><V><I><N><R><F><T><R><R><A><S><V><C><A><E><A><Y><N><P><D><E><E><E><D><D><A><E><S><R><I><I><H><P><K><T><D><D><Q><R><N><R><L><Q><E><A><C><K><D><I><L><L><F><K><N><L><D><P><E><Q><M><S><Q><V><L><D><A><M><F><E><K><L><V><K><D><G><E><H><V><I><D><Q><G><D><D><G><D><N><F><Y><V><I><D><R><G><T><F><D><I><Y><V><K><C><D><G><V><G><R><C><V><G><N><Y><D><N><R><G><S><F><G><E><L><A><L><M><Y><N><T><P><R><A><A><T><I><T><A><T><S><P><G><A><L><W><G><L><D><R><V><T><F><R><R><I><I><V><K><N><N><A><K><K><R><K><M><Y><E><S><F><I><E><S><L><P><F><L><K><S><L><E><F><S><E><R><L><K><V><V><D><V><I><G><T><K><V><Y><N><D><G><E><Q><I><I><A><Q><G><D><S><A><D><S><F><F><I><V><E><S><G><E><V><K><I><T><M><K><R><K><G><K><S><E><V><E><E><N><G><A><V><E><I><A><R><C><S><R><G><Q><Y><F><G><E><L><A><L><V><T><N><K><P><R><A><A><S><A><H><A><I><G><T><V><K><C><L><A><M><D><V><Q><A><F><E><R><L><L><G><P><C><M><E><I><M><K><R><N><I><A><T><Y><E><E><Q><L><V><A><L><F><G><T><N><M><D><I><V><E><P><T><A> | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.<BOP> | P31323 |
Q96J01 | THOC3_HUMAN | hTREX45 | Homo | <M><A><V><P><A><A><A><M><G><P><S><A><L><G><Q><S><G><P><G><S><M><A><P><W><C><S><V><S><S><G><P><S><R><Y><V><L><G><M><Q><E><L><F><R><G><H><S><K><T><R><E><F><L><A><H><S><A><K><V><H><S><V><A><W><S><C><D><G><R><R><L><A><S><G><S><F><D><K><T><A><S><V><F><L><L><E><K><D><R><L><V><K><E><N><N><Y><R><G><H><G><D><S><V><D><Q><L><C><W><H><P><S><N><P><D><L><F><V><T><A><S><G><D><K><T><I><R><I><W><D><V><R><T><T><K><C><I><A><T><V><N><T><K><G><E><N><I><N><I><C><W><S><P><D><G><Q><T><I><A><V><G><N><K><D><D><V><V><T><F><I><D><A><K><T><H><R><S><K><A><E><E><Q><F><K><F><E><V><N><E><I><S><W><N><N><D><N><N><M><F><F><L><T><N><G><N><G><C><I><N><I><L><S><Y><P><E><L><K><P><V><Q><S><I><N><A><H><P><S><N><C><I><C><I><K><F><D><P><M><G><K><Y><F><A><T><G><S><A><D><A><L><V><S><L><W><D><V><D><E><L><V><C><V><R><C><F><S><R><L><D><W><P><V><R><T><L><S><F><S><H><D><G><K><M><L><A><S><A><S><E><D><H><F><I><D><I><A><E><V><E><T><G><D><K><L><W><E><V><Q><C><E><S><P><T><F><T><V><A><W><H><P><K><R><P><L><L><A><F><A><C><D><D><K><D><G><K><Y><D><S><S><R><E><A><G><T><V><K><L><F><G><L><P><N><D><S> | Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.<BOP> | Q96J01 |
A0A0B4J273 | TVA34_HUMAN | T cell receptor alpha variable 34 | Homo | <M><E><T><V><L><Q><V><L><L><G><I><L><G><F><Q><A><A><W><V><S><S><Q><E><L><E><Q><S><P><Q><S><L><I><V><Q><E><G><K><N><L><T><I><N><C><T><S><S><K><T><L><Y><G><L><Y><W><Y><K><Q><K><Y><G><E><G><L><I><F><L><M><M><L><Q><K><G><G><E><E><K><S><H><E><K><I><T><A><K><L><D><E><K><K><Q><Q><S><S><L><H><I><T><A><S><Q><P><S><H><A><G><I><Y><L><C><G><A><D> | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0B4J273 |
P27986 | P85A_HUMAN | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha | Homo | <M><S><A><E><G><Y><Q><Y><R><A><L><Y><D><Y><K><K><E><R><E><E><D><I><D><L><H><L><G><D><I><L><T><V><N><K><G><S><L><V><A><L><G><F><S><D><G><Q><E><A><R><P><E><E><I><G><W><L><N><G><Y><N><E><T><T><G><E><R><G><D><F><P><G><T><Y><V><E><Y><I><G><R><K><K><I><S><P><P><T><P><K><P><R><P><P><R><P><L><P><V><A><P><G><S><S><K><T><E><A><D><V><E><Q><Q><A><L><T><L><P><D><L><A><E><Q><F><A><P><P><D><I><A><P><P><L><L><I><K><L><V><E><A><I><E><K><K><G><L><E><C><S><T><L><Y><R><T><Q><S><S><S><N><L><A><E><L><R><Q><L><L><D><C><D><T><P><S><V><D><L><E><M><I><D><V><H><V><L><A><D><A><F><K><R><Y><L><L><D><L><P><N><P><V><I><P><A><A><V><Y><S><E><M><I><S><L><A><P><E><V><Q><S><S><E><E><Y><I><Q><L><L><K><K><L><I><R><S><P><S><I><P><H><Q><Y><W><L><T><L><Q><Y><L><L><K><H><F><F><K><L><S><Q><T><S><S><K><N><L><L><N><A><R><V><L><S><E><I><F><S><P><M><L><F><R><F><S><A><A><S><S><D><N><T><E><N><L><I><K><V><I><E><I><L><I><S><T><E><W><N><E><R><Q><P><A><P><A><L><P><P><K><P><P><K><P><T><T><V><A><N><N><G><M><N><N><N><M><S><L><Q><D><A><E><W><Y><W><G><D><I><S><R><E><E><V><N><E><K><L><R><D><T><A><D><G><T><F><L><V><R><D><A><S><T><K><M><H><G><D><Y><T><L><T><L><R><K><G><G><N><N><K><L><I><K><I><F><H><R><D><G><K><Y><G><F><S><D><P><L><T><F><S><S><V><V><E><L><I><N><H><Y><R><N><E><S><L><A><Q><Y><N><P><K><L><D><V><K><L><L><Y><P><V><S><K><Y><Q><Q><D><Q><V><V><K><E><D><N><I><E><A><V><G><K><K><L><H><E><Y><N><T><Q><F><Q><E><K><S><R><E><Y><D><R><L><Y><E><E><Y><T><R><T><S><Q><E><I><Q><M><K><R><T><A><I><E><A><F><N><E><T><I><K><I><F><E><E><Q><C><Q><T><Q><E><R><Y><S><K><E><Y><I><E><K><F><K><R><E><G><N><E><K><E><I><Q><R><I><M><H><N><Y><D><K><L><K><S><R><I><S><E><I><I><D><S><R><R><R><L><E><E><D><L><K><K><Q><A><A><E><Y><R><E><I><D><K><R><M><N><S><I><K><P><D><L><I><Q><L><R><K><T><R><D><Q><Y><L><M><W><L><T><Q><K><G><V><R><Q><K><K><L><N><E><W><L><G><N><E><N><T><E><D><Q><Y><S><L><V><E><D><D><E><D><L><P><H><H><D><E><K><T><W><N><V><G><S><S><N><R><N><K><A><E><N><L><L><R><G><K><R><D><G><T><F><L><V><R><E><S><S><K><Q><G><C><Y><A><C><S><V><V><V><D><G><E><V><K><H><C><V><I><N><K><T><A><T><G><Y><G><F><A><E><P><Y><N><L><Y><S><S><L><K><E><L><V><L><H><Y><Q><H><T><S><L><V><Q><H><N><D><S><L><N><V><T><L><A><Y><P><V><Y><A><Q><Q><R><R> | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling . Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement .<BOP> | P27986 |
Q3B726 | RPA43_HUMAN | Twist neighbor protein | Homo | <M><A><A><G><C><S><E><A><P><R><P><A><A><A><S><D><G><S><L><V><G><Q><A><G><V><L><P><C><L><E><L><P><T><Y><A><A><A><C><A><L><V><N><S><R><Y><S><C><L><V><A><G><P><H><Q><R><H><I><A><L><S><P><R><Y><L><N><R><K><R><T><G><I><R><E><Q><L><D><A><E><L><L><R><Y><S><E><S><L><L><G><V><P><I><A><Y><D><N><I><K><V><V><G><E><L><G><D><I><Y><D><D><Q><G><H><I><H><L><N><I><E><A><D><F><V><I><F><C><P><E><P><G><Q><K><L><M><G><I><V><N><K><V><S><S><S><H><I><G><C><L><V><H><G><C><F><N><A><S><I><P><K><P><E><Q><L><S><A><E><Q><W><Q><T><M><E><I><N><M><G><D><E><L><E><F><E><V><F><R><L><D><S><D><A><A><G><V><F><C><I><R><G><K><L><N><I><T><S><L><Q><F><K><R><S><E><V><S><E><E><V><T><E><N><G><T><E><E><A><A><K><K><P><K><K><K><K><K><K><K><D><P><E><T><Y><E><V><D><S><G><T><T><K><L><A><D><D><A><D><D><T><P><M><E><E><S><A><L><Q><N><T><N><N><A><N><G><I><W><E><E><E><P><K><K><K><K><K><K><K><K><H><Q><E><V><Q><D><Q><D><P><V><F><Q><G><S><D><S><S><G><Y><Q><S><D><H><K><K><K><K><K><K><R><K><H><S><E><E><A><E><F><T><P><P><L><K><C><S><P><K><R><K><G><K><S><N><F><L> | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.<BOP> | Q3B726 |
Q9Y5S1 | TRPV2_HUMAN | Vanilloid receptor-like protein 1 | Homo | <M><T><S><P><S><S><S><P><V><F><R><L><E><T><L><D><G><G><Q><E><D><G><S><E><A><D><R><G><K><L><D><F><G><S><G><L><P><P><M><E><S><Q><F><Q><G><E><D><R><K><F><A><P><Q><I><R><V><N><L><N><Y><R><K><G><T><G><A><S><Q><P><D><P><N><R><F><D><R><D><R><L><F><N><A><V><S><R><G><V><P><E><D><L><A><G><L><P><E><Y><L><S><K><T><S><K><Y><L><T><D><S><E><Y><T><E><G><S><T><G><K><T><C><L><M><K><A><V><L><N><L><K><D><G><V><N><A><C><I><L><P><L><L><Q><I><D><R><D><S><G><N><P><Q><P><L><V><N><A><Q><C><T><D><D><Y><Y><R><G><H><S><A><L><H><I><A><I><E><K><R><S><L><Q><C><V><K><L><L><V><E><N><G><A><N><V><H><A><R><A><C><G><R><F><F><Q><K><G><Q><G><T><C><F><Y><F><G><E><L><P><L><S><L><A><A><C><T><K><Q><W><D><V><V><S><Y><L><L><E><N><P><H><Q><P><A><S><L><Q><A><T><D><S><Q><G><N><T><V><L><H><A><L><V><M><I><S><D><N><S><A><E><N><I><A><L><V><T><S><M><Y><D><G><L><L><Q><A><G><A><R><L><C><P><T><V><Q><L><E><D><I><R><N><L><Q><D><L><T><P><L><K><L><A><A><K><E><G><K><I><E><I><F><R><H><I><L><Q><R><E><F><S><G><L><S><H><L><S><R><K><F><T><E><W><C><Y><G><P><V><R><V><S><L><Y><D><L><A><S><V><D><S><C><E><E><N><S><V><L><E><I><I><A><F><H><C><K><S><P><H><R><H><R><M><V><V><L><E><P><L><N><K><L><L><Q><A><K><W><D><L><L><I><P><K><F><F><L><N><F><L><C><N><L><I><Y><M><F><I><F><T><A><V><A><Y><H><Q><P><T><L><K><K><Q><A><A><P><H><L><K><A><E><V><G><N><S><M><L><L><T><G><H><I><L><I><L><L><G><G><I><Y><L><L><V><G><Q><L><W><Y><F><W><R><R><H><V><F><I><W><I><S><F><I><D><S><Y><F><E><I><L><F><L><F><Q><A><L><L><T><V><V><S><Q><V><L><C><F><L><A><I><E><W><Y><L><P><L><L><V><S><A><L><V><L><G><W><L><N><L><L><Y><Y><T><R><G><F><Q><H><T><G><I><Y><S><V><M><I><Q><K><V><I><L><R><D><L><L><R><F><L><L><I><Y><L><V><F><L><F><G><F><A><V><A><L><V><S><L><S><Q><E><A><W><R><P><E><A><P><T><G><P><N><A><T><E><S><V><Q><P><M><E><G><Q><E><D><E><G><N><G><A><Q><Y><R><G><I><L><E><A><S><L><E><L><F><K><F><T><I><G><M><G><E><L><A><F><Q><E><Q><L><H><F><R><G><M><V><L><L><L><L><L><A><Y><V><L><L><T><Y><I><L><L><L><N><M><L><I><A><L><M><S><E><T><V><N><S><V><A><T><D><S><W><S><I><W><K><L><Q><K><A><I><S><V><L><E><M><E><N><G><Y><W><W><C><R><K><K><Q><R><A><G><V><M><L><T><V><G><T><K><P><D><G><S><P><D><E><R><W><C><F><R><V><E><E><V><N><W><A><S><W><E><Q><T><L><P><T><L><C><E><D><P><S><G><A><G><V><P><R><T><L><E><N><P><V><L><A><S><P><P><K><E><D><E><D><G><A><S><E><E><N><Y><V><P><V><Q><L><L><Q><S><N> | Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.<BOP> | Q9Y5S1 |
P29622 | KAIN_HUMAN | Serpin A4 | Homo | <M><H><L><I><D><Y><L><L><L><L><L><V><G><L><L><A><L><S><H><G><Q><L><H><V><E><H><D><G><E><S><C><S><N><S><S><H><Q><Q><I><L><E><T><G><E><G><S><P><S><L><K><I><A><P><A><N><A><D><F><A><F><R><F><Y><Y><L><I><A><S><E><T><P><G><K><N><I><F><F><S><P><L><S><I><S><A><A><Y><A><M><L><S><L><G><A><C><S><H><S><R><S><Q><I><L><E><G><L><G><F><N><L><T><E><L><S><E><S><D><V><H><R><G><F><Q><H><L><L><H><T><L><N><L><P><G><H><G><L><E><T><R><V><G><S><A><L><F><L><S><H><N><L><K><F><L><A><K><F><L><N><D><T><M><A><V><Y><E><A><K><L><F><H><T><N><F><Y><D><T><V><G><T><I><Q><L><I><N><D><H><V><K><K><E><T><R><G><K><I><V><D><L><V><S><E><L><K><K><D><V><L><M><V><L><V><N><Y><I><Y><F><K><A><L><W><E><K><P><F><I><S><S><R><T><T><P><K><D><F><Y><V><D><E><N><T><T><V><R><V><P><M><M><L><Q><D><Q><E><H><H><W><Y><L><H><D><R><Y><L><P><C><S><V><L><R><M><D><Y><K><G><D><A><T><V><F><F><I><L><P><N><Q><G><K><M><R><E><I><E><E><V><L><T><P><E><M><L><M><R><W><N><N><L><L><R><K><R><N><F><Y><K><K><L><E><L><H><L><P><K><F><S><I><S><G><S><Y><V><L><D><Q><I><L><P><R><L><G><F><T><D><L><F><S><K><W><A><D><L><S><G><I><T><K><Q><Q><K><L><E><A><S><K><S><F><H><K><A><T><L><D><V><D><E><A><G><T><E><A><A><A><A><T><S><F><A><I><K><F><F><S><A><Q><T><N><R><H><I><L><R><F><N><R><P><F><L><V><V><I><F><S><T><S><T><Q><S><V><L><F><L><G><K><V><V><D><P><T><K><P> | Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.<BOP> | P29622 |
P43629 | KI3L1_HUMAN | p70 natural killer cell receptor clones CL-2/CL-11 | Homo | <M><S><L><M><V><V><S><M><A><C><V><G><L><F><L><V><Q><R><A><G><P><H><M><G><G><Q><D><K><P><F><L><S><A><W><P><S><A><V><V><P><R><G><G><H><V><T><L><R><C><H><Y><R><H><R><F><N><N><F><M><L><Y><K><E><D><R><I><H><I><P><I><F><H><G><R><I><F><Q><E><S><F><N><M><S><P><V><T><T><A><H><A><G><N><Y><T><C><R><G><S><H><P><H><S><P><T><G><W><S><A><P><S><N><P><V><V><I><M><V><T><G><N><H><R><K><P><S><L><L><A><H><P><G><P><L><V><K><S><G><E><R><V><I><L><Q><C><W><S><D><I><M><F><E><H><F><F><L><H><K><E><G><I><S><K><D><P><S><R><L><V><G><Q><I><H><D><G><V><S><K><A><N><F><S><I><G><P><M><M><L><A><L><A><G><T><Y><R><C><Y><G><S><V><T><H><T><P><Y><Q><L><S><A><P><S><D><P><L><D><I><V><V><T><G><P><Y><E><K><P><S><L><S><A><Q><P><G><P><K><V><Q><A><G><E><S><V><T><L><S><C><S><S><R><S><S><Y><D><M><Y><H><L><S><R><E><G><G><A><H><E><R><R><L><P><A><V><R><K><V><N><R><T><F><Q><A><D><F><P><L><G><P><A><T><H><G><G><T><Y><R><C><F><G><S><F><R><H><S><P><Y><E><W><S><D><P><S><D><P><L><L><V><S><V><T><G><N><P><S><S><S><W><P><S><P><T><E><P><S><S><K><S><G><N><P><R><H><L><H><I><L><I><G><T><S><V><V><I><I><L><F><I><L><L><L><F><F><L><L><H><L><W><C><S><N><K><K><N><A><A><V><M><D><Q><E><P><A><G><N><R><T><A><N><S><E><D><S><D><E><Q><D><P><E><E><V><T><Y><A><Q><L><D><H><C><V><F><T><Q><R><K><I><T><R><P><S><Q><R><P><K><T><P><P><T><D><T><I><L><Y><T><E><L><P><N><A><K><P><R><S><K><V><V><S><C><P> | Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.<BOP> | P43629 |
Q9Y232 | CDYL_HUMAN | Crotonyl-CoA hydratase | Homo | <M><T><F><Q><A><S><H><R><S><A><W><G><K><S><R><K><K><N><W><Q><Y><E><G><P><T><Q><K><L><F><L><K><R><N><N><V><S><A><P><D><G><P><S><D><P><S><I><S><V><S><S><E><Q><S><G><A><Q><Q><P><P><A><L><Q><V><E><R><I><V><D><K><R><K><N><K><K><G><K><T><E><Y><L><V><R><W><K><G><Y><D><S><E><D><D><T><W><E><P><E><Q><H><L><V><N><C><E><E><Y><I><H><D><F><N><R><R><H><T><E><K><Q><K><E><S><T><L><T><R><T><N><R><T><S><P><N><N><A><R><K><Q><I><S><R><S><T><N><S><N><F><S><K><T><S><P><K><A><L><V><I><G><K><D><H><E><S><K><N><S><Q><L><F><A><A><S><Q><K><F><R><K><N><T><A><P><S><L><S><S><R><K><N><M><D><L><A><K><S><G><I><K><I><L><V><P><K><S><P><V><K><S><R><T><A><V><D><G><F><Q><S><E><S><P><E><K><L><D><P><V><E><Q><G><Q><E><D><T><V><A><P><E><V><A><A><E><K><P><V><G><A><L><L><G><P><G><A><E><R><A><R><M><G><S><R><P><R><I><H><P><L><V><P><Q><V><P><G><P><V><T><A><A><M><A><T><G><L><A><V><N><G><K><G><T><S><P><F><M><D><A><L><T><A><N><G><T><T><N><I><Q><T><S><V><T><G><V><T><A><S><K><R><K><F><I><D><D><R><R><D><Q><P><F><D><K><R><L><R><F><S><V><R><Q><T><E><S><A><Y><R><Y><R><D><I><V><V><R><K><Q><D><G><F><T><H><I><L><L><S><T><K><S><S><E><N><N><S><L><N><P><E><V><M><R><E><V><Q><S><A><L><S><T><A><A><A><D><D><S><K><L><V><L><L><S><A><V><G><S><V><F><C><C><G><L><D><F><I><Y><F><I><R><R><L><T><D><D><R><K><R><E><S><T><K><M><A><E><A><I><R><N><F><V><N><T><F><I><Q><F><K><K><P><I><I><V><A><V><N><G><P><A><I><G><L><G><A><S><I><L><P><L><C><D><V><V><W><A><N><E><K><A><W><F><Q><T><P><Y><T><T><F><G><Q><S><P><D><G><C><S><T><V><M><F><P><K><I><M><G><G><A><S><A><N><E><M><L><L><S><G><R><K><L><T><A><Q><E><A><C><G><K><G><L><V><S><Q><V><F><W><P><G><T><F><T><Q><E><V><M><V><R><I><K><E><L><A><S><C><N><P><V><V><L><E><E><S><K><A><L><V><R><C><N><M><K><M><E><L><E><Q><A><N><E><R><E><C><E><V><L><K><K><I><W><G><S><A><Q><G><M><D><S><M><L><K><Y><L><Q><R><K><I><D><E><F> | Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain . Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin.<BOP> | Q9Y232 |
Q8IYM2 | SLN12_HUMAN | Schlafen family member 12 | Homo | <M><N><I><S><V><D><L><E><T><N><Y><A><E><L><V><L><D><V><G><R><V><T><L><G><E><N><S><R><K><K><M><K><D><C><K><L><R><K><K><Q><N><E><S><V><S><R><A><M><C><A><L><L><N><S><G><G><G><V><I><K><A><E><I><E><N><E><D><Y><S><Y><T><K><D><G><I><G><L><D><L><E><N><S><F><S><N><I><L><L><F><V><P><E><Y><L><D><F><M><Q><N><G><N><Y><F><L><I><F><V><K><S><W><S><L><N><T><S><G><L><R><I><T><T><L><S><S><N><L><Y><K><R><D><I><T><S><A><K><V><M><N><A><T><A><A><L><E><F><L><K><D><M><K><K><T><R><G><R><L><Y><L><R><P><E><L><L><A><K><R><P><C><V><D><I><Q><E><E><N><N><M><K><A><L><A><G><V><F><F><D><R><T><E><L><D><R><K><E><K><L><T><F><T><E><S><T><H><V><E><I><K><N><F><S><T><E><K><L><L><Q><R><I><K><E><I><L><P><Q><Y><V><S><A><F><A><N><T><D><G><G><Y><L><F><I><G><L><N><E><D><K><E><I><I><G><F><K><A><E><M><S><D><L><D><D><L><E><R><E><I><E><K><S><I><R><K><M><P><V><H><H><F><C><M><E><K><K><K><I><N><Y><S><C><K><F><L><G><V><Y><D><K><G><S><L><C><G><Y><V><C><A><L><R><V><E><R><F><C><C><A><V><F><A><K><E><P><D><S><W><H><V><K><D><N><R><V><M><Q><L><T><R><K><E><W><I><Q><F><M><V><E><A><E><P><K><F><S><S><S><Y><E><E><V><I><S><Q><I><N><T><S><L><P><A><P><H><S><W><P><L><L><E><W><Q><R><Q><R><H><H><C><P><G><L><S><G><R><I><T><Y><T><P><E><N><L><C><R><K><L><F><L><Q><H><E><G><L><K><Q><L><I><C><E><E><M><D><S><V><R><K><G><S><L><I><F><S><R><S><W><S><V><D><L><G><L><Q><E><N><H><K><V><L><C><D><A><L><L><I><S><Q><D><S><P><P><V><L><Y><T><F><H><M><V><Q><D><E><E><F><K><G><Y><S><T><Q><T><A><L><T><L><K><Q><K><L><A><K><I><G><G><Y><T><K><K><V><C><V><M><T><K><I><F><Y><L><S><P><E><G><M><T><S><C><Q><Y><D><L><R><S><Q><V><I><Y><P><E><S><Y><Y><F><T><R><R><K><Y><L><L><K><A><L><F><K><A><L><K><R><L><K><S><L><R><D><Q><F><S><F><A><E><N><L><Y><Q><I><I><G><I><D><C><F><Q><K><N><D><K><K><M><F><K><S><C><R><R><L><T> | Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling . May play a role in cell differentiation .<BOP> | Q8IYM2 |
P58180 | OR4D2_HUMAN | Olfactory receptor OR17-24 | Homo | <M><E><T><G><N><L><T><W><V><S><D><F><V><F><L><G><L><S><Q><T><R><E><L><Q><R><F><L><F><L><M><F><L><F><V><Y><I><T><T><V><M><G><N><I><L><I><I><I><T><V><T><S><D><S><Q><L><H><T><P><M><Y><F><L><L><R><N><L><A><V><L><D><L><C><F><S><S><V><T><A><P><K><M><L><V><D><L><L><S><E><K><K><T><I><S><Y><Q><G><C><M><G><Q><I><F><F><F><H><F><L><G><G><A><M><V><F><F><L><S><V><M><A><F><D><R><L><I><A><I><S><R><P><L><R><Y><V><T><V><M><N><T><Q><L><W><V><G><L><V><V><A><T><W><V><G><G><F><V><H><S><I><V><Q><L><A><L><M><L><P><L><P><F><C><G><P><N><I><L><D><N><F><Y><C><D><V><P><Q><V><L><R><L><A><C><T><D><T><S><L><L><E><F><L><K><I><S><N><S><G><L><L><D><V><V><W><F><F><L><L><L><M><S><Y><L><F><I><L><V><M><L><R><S><H><P><G><E><A><R><R><K><A><A><S><T><C><T><T><H><I><I><V><V><S><M><I><F><V><P><S><I><Y><L><Y><A><R><P><F><T><P><F><P><M><D><K><L><V><S><I><G><H><T><V><M><T><P><M><L><N><P><M><I><Y><T><L><R><N><Q><D><M><Q><A><A><V><R><R><L><G><R><H><R><L><V> | Odorant receptor.<BOP> | P58180 |
Q9NVT9 | ARMC1_HUMAN | Armadillo repeat-containing protein 1 | Homo | <M><N><S><S><T><S><T><M><S><E><E><P><D><A><L><S><V><V><N><Q><L><R><D><L><A><A><D><P><L><N><R><R><A><I><V><Q><D><Q><G><C><L><P><G><L><I><L><F><M><D><H><P><N><P><P><V><V><H><S><A><L><L><A><L><R><Y><L><A><E><C><R><A><N><R><E><K><M><K><G><E><L><G><M><M><L><S><L><Q><N><V><I><Q><K><T><T><T><P><G><E><T><K><L><L><A><S><E><I><Y><D><I><L><Q><S><S><N><M><A><D><G><D><S><F><N><E><M><N><S><R><R><R><K><A><Q><F><F><L><G><T><T><N><K><R><A><K><T><V><V><L><H><I><D><G><L><D><D><T><S><R><R><N><L><C><E><E><A><L><L><K><I><K><G><V><I><S><F><T><F><Q><M><A><V><Q><R><C><V><V><R><I><R><S><D><L><K><A><E><A><L><A><S><A><I><A><S><T><K><V><M><K><A><Q><Q><V><V><K><S><E><S><G><E><E><M><L><V><P><F><Q><D><T><P><V><E><V><E><Q><N><T><E><L><P><D><Y><L><P><E><D><E><S><P><T><K><E><Q><D><K><A><V><S><R><V><G><S><H><P><E><G><G><A><S><W><L><S><T><A><A><N><F><L><S><R><S><F><Y><W> | In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.<BOP> | Q9NVT9 |
O95361 | TRI16_HUMAN | Estrogen-responsive B box protein | Homo | <M><A><E><L><D><L><M><A><P><G><P><L><P><R><A><T><A><Q><P><P><A><P><L><S><P><D><S><G><S><P><S><P><D><S><G><S><A><S><P><V><E><E><E><D><V><G><S><S><E><K><L><G><R><E><T><E><E><Q><D><S><D><S><A><E><Q><G><D><P><A><G><E><G><K><E><V><L><C><D><F><C><L><D><D><T><R><R><V><K><A><V><K><S><C><L><T><C><M><V><N><Y><C><E><E><H><L><Q><P><H><Q><V><N><I><K><L><Q><S><H><L><L><T><E><P><V><K><D><H><N><W><R><Y><C><P><A><H><H><S><P><L><S><A><F><C><C><P><D><Q><Q><C><I><C><Q><D><C><C><Q><E><H><S><G><H><T><I><V><S><L><D><A><A><R><R><D><K><E><A><E><L><Q><C><T><Q><L><D><L><E><R><K><L><K><L><N><E><N><A><I><S><R><L><Q><A><N><Q><K><S><V><L><V><S><V><S><E><V><K><A><V><A><E><M><Q><F><G><E><L><L><A><A><V><R><K><A><Q><A><N><V><M><L><F><L><E><E><K><E><Q><A><A><L><S><Q><A><N><G><I><K><A><H><L><E><Y><R><S><A><E><M><E><K><S><K><Q><E><L><E><R><M><A><A><I><S><N><T><V><Q><F><L><E><E><Y><C><K><F><K><N><T><E><D><I><T><F><P><S><V><Y><V><G><L><K><D><K><L><S><G><I><R><K><V><I><T><E><S><T><V><H><L><I><Q><L><L><E><N><Y><K><K><K><L><Q><E><F><S><K><E><E><E><Y><D><I><R><T><Q><V><S><A><V><V><Q><R><K><Y><W><T><S><K><P><E><P><S><T><R><E><Q><F><L><Q><Y><A><Y><D><I><T><F><D><P><D><T><A><H><K><Y><L><R><L><Q><E><E><N><R><K><V><T><N><T><T><P><W><E><H><P><Y><P><D><L><P><S><R><F><L><H><W><R><Q><V><L><S><Q><Q><S><L><Y><L><H><R><Y><Y><F><E><V><E><I><F><G><A><G><T><Y><V><G><L><T><C><K><G><I><D><R><K><G><E><E><R><N><S><C><I><S><G><N><N><F><S><W><S><L><Q><W><N><G><K><E><F><T><A><W><Y><S><D><M><E><T><P><L><K><A><G><P><F><R><R><L><G><V><Y><I><D><F><P><G><G><I><L><S><F><Y><G><V><E><Y><D><T><M><T><L><V><H><K><F><A><C><K><F><S><E><P><V><Y><A><A><F><W><L><S><K><K><E><N><A><I><R><I><V><D><L><G><E><E><P><E><K><P><A><P><S><L><V><G><T><A><P> | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.<BOP> | O95361 |
Q9BWC9 | CC106_HUMAN | Coiled-coil domain-containing protein 106 | Homo | <M><N><D><R><S><S><R><R><R><T><M><K><D><D><E><T><F><E><I><S><I><P><F><D><E><A><P><H><L><D><P><Q><I><F><Y><S><L><S><P><S><R><R><N><F><E><E><P><P><E><A><A><S><S><A><L><A><L><M><N><S><V><K><T><Q><L><H><M><A><L><E><R><N><S><W><L><Q><K><R><I><E><D><L><E><E><E><R><D><F><L><R><C><Q><L><D><K><F><I><S><S><A><R><M><E><A><E><D><H><C><R><M><K><P><G><P><R><R><M><E><G><D><S><R><G><G><A><G><G><E><A><S><D><P><E><S><A><A><S><S><L><S><G><A><S><E><E><G><S><A><S><E><R><R><R><Q><K><Q><K><G><G><A><S><R><R><R><F><G><K><P><K><A><R><E><R><Q><R><V><K><D><A><D><G><V><L><C><R><Y><K><K><I><L><G><T><F><Q><K><L><K><S><M><S><R><A><F><E><H><H><R><V><D><R><N><T><V><A><L><T><T><P><I><A><E><L><L><I><V><A><P><E><K><L><A><E><V><G><E><F><D><P><S><K><E><R><L><L><E><Y><S><R><R><C><F><L><A><L><D><D><E><T><L><K><K><V><Q><A><L><K><K><S><K><L><L><L><P><I><T><Y><R><F><K><R> | Promotes the degradation of p53/TP53 protein and inhibits its transactivity.<BOP> | Q9BWC9 |
Q86UY5 | FA83A_HUMAN | Tumor-specific gene expressed in prostate protein | Homo | <M><S><R><S><R><H><L><G><K><I><R><K><R><L><E><D><V><K><S><Q><W><V><R><P><A><R><A><D><F><S><D><N><E><S><A><R><L><A><T><D><A><L><L><D><G><G><S><E><A><Y><W><R><V><L><S><Q><E><G><E><V><D><F><L><S><S><V><E><A><Q><Y><I><Q><A><Q><A><R><E><P><P><C><P><P><D><T><L><G><G><A><E><A><G><P><K><G><L><D><S><S><S><L><Q><S><G><T><Y><F><P><V><A><S><E><G><S><E><P><A><L><L><H><S><W><A><S><A><E><K><P><Y><L><K><E><K><S><S><A><T><V><Y><F><Q><T><V><K><H><N><N><I><R><D><L><V><R><R><C><I><T><R><T><S><Q><V><L><V><I><L><M><D><V><F><T><D><V><E><I><F><C><D><I><L><E><A><A><N><K><R><G><V><F><V><C><V><L><L><D><Q><G><G><V><K><L><F><Q><E><M><C><D><K><V><Q><I><S><D><S><H><L><K><N><I><S><I><R><S><V><E><G><E><I><Y><C><A><K><S><G><R><K><F><A><G><Q><I><R><E><K><F><I><I><S><D><W><R><F><V><L><S><G><S><Y><S><F><T><W><L><C><G><H><V><H><R><N><I><L><S><K><F><T><G><Q><A><V><E><L><F><D><E><E><F><R><H><L><Y><A><S><S><K><P><V><M><G><L><K><S><P><R><L><V><A><P><V><P><P><G><A><A><P><A><N><G><R><L><S><S><S><S><G><S><A><S><D><R><T><S><S><N><P><F><S><G><R><S><A><G><S><H><P><G><T><R><S><V><S><A><S><S><G><P><C><S><P><A><A><P><H><P><P><P><P><P><R><F><Q><P><H><Q><G><P><W><G><A><P><S><P><Q><A><H><L><S><P><R><P><H><D><G><P><P><A><A><V><Y><S><N><L><G><A><Y><R><P><T><R><L><Q><L><E><Q><L><G><L><V><P><R><L><T><P><T><W><R><P><F><L><Q><A><S><P><H><F> | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation.<BOP> | Q86UY5 |
Q15428 | SF3A2_HUMAN | Spliceosome-associated protein 62 | Homo | <M><D><F><Q><H><R><P><G><G><K><T><G><S><G><G><V><A><S><S><S><E><S><N><R><D><R><R><E><R><L><R><Q><L><A><L><E><T><I><D><I><N><K><D><P><Y><F><M><K><N><H><L><G><S><Y><E><C><K><L><C><L><T><L><H><N><N><E><G><S><Y><L><A><H><T><Q><G><K><K><H><Q><T><N><L><A><R><R><A><A><K><E><A><K><E><A><P><A><Q><P><A><P><E><K><V><K><V><E><V><K><K><F><V><K><I><G><R><P><G><Y><K><V><T><K><Q><R><D><S><E><M><G><Q><Q><S><L><L><F><Q><I><D><Y><P><E><I><A><E><G><I><M><P><R><H><R><F><M><S><A><Y><E><Q><R><I><E><P><P><D><R><R><W><Q><Y><L><L><M><A><A><E><P><Y><E><T><I><A><F><K><V><P><S><R><E><I><D><K><A><E><G><K><F><W><T><H><W><N><R><E><T><K><Q><F><F><L><Q><F><H><F><K><M><E><K><P><P><A><P><P><S><L><P><A><G><P><P><G><V><K><R><P><P><P><P><L><M><N><G><L><P><P><R><P><P><L><P><E><S><L><P><P><P><P><P><G><G><L><P><L><P><P><M><P><P><T><G><P><A><P><S><G><P><P><G><P><P><Q><L><P><P><P><A><P><G><V><H><P><P><A><P><V><V><H><P><P><A><S><G><V><H><P><P><A><P><G><V><H><P><P><A><P><G><V><H><P><P><A><P><G><V><H><P><P><T><S><G><V><H><P><P><A><P><G><V><H><P><P><A><P><G><V><H><P><P><A><P><G><V><H><P><P><A><P><G><V><H><P><P><A><P><G><V><H><P><P><P><S><A><G><V><H><P><Q><A><P><G><V><H><P><A><A><P><A><V><H><P><Q><A><P><G><V><H><P><P><A><P><G><M><H><P><Q><A><P><G><V><H><P><Q><P><P><G><V><H><P><S><A><P><G><V><H><P><Q><P><P><G><V><H><P><S><N><P><G><V><H><P><P><T><P><M><P><P><M><L><R><P><P><L><P><S><E><G><P><G><N><I><P><P><P><P><P><T><N> | Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex . Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex . Interacts directly with the duplex formed by U2 snRNA and the intron .<BOP> | Q15428 |
Q96SK3 | ZN607_HUMAN | Zinc finger protein 607 | Homo | <M><S><Y><G><S><I><T><F><G><D><V><A><I><D><F><S><H><Q><E><W><E><Y><L><S><L><V><Q><K><T><L><Y><Q><E><V><M><M><E><N><Y><D><N><L><V><S><L><A><G><H><S><V><S><K><P><D><L><I><T><L><L><E><Q><G><K><E><P><W><M><I><V><R><E><E><T><R><G><E><C><T><D><L><D><S><R><C><E><I><I><S><D><G><K><M><Q><L><Y><R><K><H><S><C><V><T><L><H><Q><R><I><H><N><G><Q><K><P><Y><E><C><K><Q><C><Q><K><S><F><S><H><L><T><E><L><M><V><H><Q><T><I><H><T><S><E><E><P><D><Q><C><E><K><F><R><K><A><F><S><H><L><T><D><L><R><K><H><Q><K><I><N><A><R><E><K><P><Y><E><C><E><E><C><G><K><V><F><S><Y><P><A><N><L><A><Q><H><G><K><V><H><V><E><K><P><Y><E><C><K><E><C><G><E><A><F><R><T><S><R><Q><L><T><V><H><H><R><F><H><Y><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><V><Y><G><R><L><S><R><H><Q><S><I><H><T><G><E><K><P><F><E><C><N><K><C><G><K><S><F><R><L><K><A><G><L><K><V><H><Q><S><I><H><T><G><E><K><P><H><E><C><K><E><C><G><K><A><F><R><Q><F><S><H><L><V><G><H><K><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><G><F><T><C><R><Y><Q><L><T><M><H><Q><R><I><Y><S><G><E><K><H><Y><E><C><K><E><N><G><E><A><F><S><S><G><H><Q><L><T><A><P><H><T><F><E><S><V><E><K><P><Y><K><C><E><E><C><G><K><A><F><S><V><H><G><R><L><T><R><H><Q><G><I><H><S><G><K><K><P><Y><E><C><N><K><C><G><K><S><F><R><L><N><S><S><L><K><I><H><Q><N><I><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><S><Q><R><A><H><L><A><H><H><N><R><I><H><T><G><Y><K><P><F><E><C><K><E><C><G><K><S><F><R><C><A><S><Y><L><V><I><H><E><R><I><H><T><G><E><K><P><Y><V><C><Q><E><C><G><K><G><F><S><Y><S><H><K><L><T><I><H><R><R><V><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><V><S><G><Q><L><T><Q><H><L><S><I><H><S><G><K><K><P><F><E><C><N><K><C><G><K><S><F><R><F><I><S><V><L><K><A><H><Q><N><I><H><S><A><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><H><A><T><S><L><I><Y><H><D><R><T><H><A><G><E><K><S><Y><E><C><K><E><C><G><E><T><F><S><H><A><S><H><L><I><I><H><E><R><I><H><T><S><D><K><P><Y><E><C><K><R><C><G><K><A><F><H><C><A><S><Y><L><V><R><H><E><S><V><H><A><D><G><N><P><Y><M><C><E><E><C><G><K><A><F><N><S><S><H><E><L><S><I><H><H><R><V><H><T><G><E><K><P><F><K><C><N><K><C><R><R><S><F><R><L><R><S><I><L><E><V><H><Q><R><I><H><I> | May be involved in transcriptional regulation.<BOP> | Q96SK3 |
O14730 | RIOK3_HUMAN | sudD homolog | Homo | <M><D><L><V><G><V><A><S><P><E><P><G><T><A><A><A><W><G><P><S><K><C><P><W><A><I><P><Q><N><T><I><S><C><S><L><A><D><V><M><S><E><Q><L><A><K><E><L><Q><L><E><E><E><A><A><V><F><P><E><V><A><V><A><E><G><P><F><I><T><G><E><N><I><D><T><S><S><D><L><M><L><A><Q><M><L><Q><M><E><Y><D><R><E><Y><D><A><Q><L><R><R><E><E><K><K><F><N><G><D><S><K><V><S><I><S><F><E><N><Y><R><K><V><H><P><Y><E><D><S><D><S><S><E><D><E><V><D><W><Q><D><T><R><D><D><P><Y><R><P><A><K><P><V><P><T><P><K><K><G><F><I><G><K><G><K><D><I><T><T><K><H><D><E><V><V><C><G><R><K><N><T><A><R><M><E><N><F><A><P><E><F><Q><V><G><D><G><I><G><M><D><L><K><L><S><N><H><V><F><N><A><L><K><Q><H><A><Y><S><E><E><R><R><S><A><R><L><H><E><K><K><E><H><S><T><A><E><K><A><V><D><P><K><T><R><L><L><M><Y><K><M><V><N><S><G><M><L><E><T><I><T><G><C><I><S><T><G><K><E><S><V><V><F><H><A><Y><G><G><S><M><E><D><E><K><E><D><S><K><V><I><P><T><E><C><A><I><K><V><F><K><T><T><L><N><E><F><K><N><R><D><K><Y><I><K><D><D><F><R><F><K><D><R><F><S><K><L><N><P><R><K><I><I><R><M><W><A><E><K><E><M><H><N><L><A><R><M><Q><R><A><G><I><P><C><P><T><V><V><L><L><K><K><H><I><L><V><M><S><F><I><G><H><D><Q><V><P><A><P><K><L><K><E><V><K><L><N><S><E><E><M><K><E><A><Y><Y><Q><T><L><H><L><M><R><Q><L><Y><H><E><C><T><L><V><H><A><D><L><S><E><Y><N><M><L><W><H><A><G><K><V><W><L><I><D><V><S><Q><S><V><E><P><T><H><P><H><G><L><E><F><L><F><R><D><C><R><N><V><S><Q><F><F><Q><K><G><G><V><K><E><A><L><S><E><R><E><L><F><N><A><V><S><G><L><N><I><T><A><D><N><E><A><D><F><L><A><E><I><E><A><L><E><K><M><N><E><D><H><V><Q><K><N><G><R><K><A><A><S><F><L><K><D><D><G><D><P><P><L><L><Y><D><E> | Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 . Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling . Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway . May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA .<BOP> | O14730 |
Q8TDN6 | BRX1_HUMAN | Brix domain-containing protein 2 | Homo | <M><A><A><T><K><R><K><R><R><G><G><F><A><V><Q><A><K><K><P><K><R><N><E><I><D><A><E><P><P><A><K><R><H><A><T><A><E><E><V><E><E><E><E><R><D><R><I><P><G><P><V><C><K><G><K><W><K><N><K><E><R><I><L><I><F><S><S><R><G><I><N><F><R><T><R><H><L><M><Q><D><L><R><M><L><M><P><H><S><K><A><D><T><K><M><D><R><K><D><K><L><F><V><I><N><E><V><C><E><M><K><N><C><N><K><C><I><Y><F><E><A><K><K><K><Q><D><L><Y><M><W><L><S><N><S><P><H><G><P><S><A><K><F><L><V><Q><N><I><H><T><L><A><E><L><K><M><T><G><N><C><L><K><G><S><R><P><L><L><S><F><D><P><A><F><D><E><L><P><H><Y><A><L><L><K><E><L><L><I><Q><I><F><S><T><P><R><Y><H><P><K><S><Q><P><F><V><D><H><V><F><T><F><T><I><L><D><N><R><I><W><F><R><N><F><Q><I><I><E><E><D><A><A><L><V><E><I><G><P><R><F><V><L><N><L><I><K><I><F><Q><G><S><F><G><G><P><T><L><Y><E><N><P><H><Y><Q><S><P><N><M><H><R><R><V><I><R><S><I><T><A><A><K><Y><R><E><K><Q><Q><V><K><D><V><Q><K><L><R><K><K><E><P><K><T><L><L><P><H><D><P><T><A><D><V><F><V><T><P><A><E><E><K><P><I><E><I><Q><W><V><K><P><E><P><K><V><D><L><K><A><R><K><K><R><I><Y><K><R><Q><R><K><M><K><Q><R><M><D><S><G><K><T><K> | Required for biogenesis of the 60S ribosomal subunit.<BOP> | Q8TDN6 |
Q96RI1 | NR1H4_HUMAN | Retinoid X receptor-interacting protein 14 | Homo | <M><V><M><Q><F><Q><G><L><E><N><P><I><Q><I><S><P><H><C><S><C><T><P><S><G><F><F><M><E><M><M><S><M><K><P><A><K><G><V><L><T><E><Q><V><A><G><P><L><G><Q><N><L><E><V><E><P><Y><S><Q><Y><S><N><V><Q><F><P><Q><V><Q><P><Q><I><S><S><S><S><Y><Y><S><N><L><G><F><Y><P><Q><Q><P><E><E><W><Y><S><P><G><I><Y><E><L><R><R><M><P><A><E><T><L><Y><Q><G><E><T><E><V><A><E><M><P><V><T><K><K><P><R><M><G><A><S><A><G><R><I><K><G><D><E><L><C><V><V><C><G><D><R><A><S><G><Y><H><Y><N><A><L><T><C><E><G><C><K><G><F><F><R><R><S><I><T><K><N><A><V><Y><K><C><K><N><G><G><N><C><V><M><D><M><Y><M><R><R><K><C><Q><E><C><R><L><R><K><C><K><E><M><G><M><L><A><E><C><M><Y><T><G><L><L><T><E><I><Q><C><K><S><K><R><L><R><K><N><V><K><Q><H><A><D><Q><T><V><N><E><D><S><E><G><R><D><L><R><Q><V><T><S><T><T><K><S><C><R><E><K><T><E><L><T><P><D><Q><Q><T><L><L><H><F><I><M><D><S><Y><N><K><Q><R><M><P><Q><E><I><T><N><K><I><L><K><E><E><F><S><A><E><E><N><F><L><I><L><T><E><M><A><T><N><H><V><Q><V><L><V><E><F><T><K><K><L><P><G><F><Q><T><L><D><H><E><D><Q><I><A><L><L><K><G><S><A><V><E><A><M><F><L><R><S><A><E><I><F><N><K><K><L><P><S><G><H><S><D><L><L><E><E><R><I><R><N><S><G><I><S><D><E><Y><I><T><P><M><F><S><F><Y><K><S><I><G><E><L><K><M><T><Q><E><E><Y><A><L><L><T><A><I><V><I><L><S><P><D><R><Q><Y><I><K><D><R><E><A><V><E><K><L><Q><E><P><L><L><D><V><L><Q><K><L><C><K><I><H><Q><P><E><N><P><Q><H><F><A><C><L><L><G><R><L><T><E><L><R><T><F><N><H><H><H><A><E><M><L><M><S><W><R><V><N><D><H><K><F><T><P><L><L><C><E><I><W><D><V><Q> | Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA.<BOP> | Q96RI1 |
Q8WY07 | CTR3_HUMAN | Solute carrier family 7 member 3 | Homo | <M><P><W><Q><A><F><R><R><F><G><Q><K><L><V><R><R><R><T><L><E><S><G><M><A><E><T><R><L><A><R><C><L><S><T><L><D><L><V><A><L><G><V><G><S><T><L><G><A><G><V><Y><V><L><A><G><E><V><A><K><D><K><A><G><P><S><I><V><I><C><F><L><V><A><A><L><S><S><V><L><A><G><L><C><Y><A><E><F><G><A><R><V><P><R><S><G><S><A><Y><L><Y><S><Y><V><T><V><G><E><L><W><A><F><T><T><G><W><N><L><I><L><S><Y><V><I><G><T><A><S><V><A><R><A><W><S><S><A><F><D><N><L><I><G><N><H><I><S><K><T><L><Q><G><S><I><A><L><H><V><P><H><V><L><A><E><Y><P><D><F><F><A><L><G><L><V><L><L><L><T><G><L><L><A><L><G><A><S><E><S><A><L><V><T><K><V><F><T><G><V><N><L><L><V><L><G><F><V><M><I><S><G><F><V><K><G><D><V><H><N><W><K><L><T><E><E><D><Y><E><L><A><M><A><E><L><N><D><T><Y><S><L><G><P><L><G><S><G><G><F><V><P><F><G><F><E><G><I><L><R><G><A><A><T><C><F><Y><A><F><V><G><F><D><C><I><A><T><T><G><E><E><A><Q><N><P><Q><R><S><I><P><M><G><I><V><I><S><L><S><V><C><F><L><A><Y><F><A><V><S><S><A><L><T><L><M><M><P><Y><Y><Q><L><Q><P><E><S><P><L><P><E><A><F><L><Y><I><G><W><A><P><A><R><Y><V><V><A><V><G><S><L><C><A><L><S><T><S><L><L><G><S><M><F><P><M><P><R><V><I><Y><A><M><A><E><D><G><L><L><F><R><V><L><A><R><I><H><T><G><T><R><T><P><I><I><A><T><V><V><S><G><I><I><A><A><F><M><A><F><L><F><K><L><T><D><L><V><D><L><M><S><I><G><T><L><L><A><Y><S><L><V><S><I><C><V><L><I><L><R><Y><Q><P><D><Q><E><T><K><T><G><E><E><V><E><L><Q><E><E><A><I><T><T><E><S><E><K><L><T><L><W><G><L><F><F><P><L><N><S><I><P><T><P><L><S><G><Q><I><V><Y><V><C><S><S><L><L><A><V><L><L><T><A><L><C><L><V><L><A><Q><W><S><V><P><L><L><S><G><D><L><L><W><T><A><V><V><V><L><L><L><L><L><I><I><G><I><I><V><V><I><W><R><Q><P><Q><S><S><T><P><L><H><F><K><V><P><A><L><P><L><L><P><L><M><S><I><F><V><N><I><Y><L><M><M><Q><M><T><A><G><T><W><A><R><F><G><V><W><M><L><I><G><F><A><I><Y><F><G><Y><G><I><Q><H><S><L><E><E><I><K><S><N><Q><P><S><R><K><S><R><A><K><T><V><D><L><D><P><G><T><L><Y><V><H><S><V> | Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.<BOP> | Q8WY07 |
Q9H0H3 | KLH25_HUMAN | Ectoderm-neural cortex protein 2 | Homo | <M><S><V><S><V><H><E><T><R><K><S><R><S><S><T><G><S><M><N><V><T><L><F><H><K><A><S><H><P><D><C><V><L><A><H><L><N><T><L><R><K><H><C><M><F><T><D><V><T><L><W><A><G><D><R><A><F><P><C><H><R><A><V><L><A><A><S><S><R><Y><F><E><A><M><F><S><H><G><L><R><E><S><R><D><D><T><V><N><F><Q><D><N><L><H><P><E><V><L><E><L><L><L><D><F><A><Y><S><S><R><I><A><I><N><E><E><N><A><E><S><L><L><E><A><G><D><M><L><Q><F><H><D><V><R><D><A><A><A><E><F><L><E><K><N><L><F><P><S><N><C><L><G><M><M><L><L><S><D><A><H><Q><C><R><R><L><Y><E><F><S><W><R><M><C><L><V><H><F><E><T><V><R><Q><S><E><D><F><N><S><L><S><K><D><T><L><L><D><L><I><S><S><D><E><L><E><T><E><D><E><R><V><V><F><E><A><I><L><Q><W><V><K><H><D><L><E><P><R><K><V><H><L><P><E><L><L><R><S><V><R><L><A><L><L><P><S><D><C><L><Q><E><A><V><S><S><E><A><L><L><M><A><D><E><R><T><K><L><I><M><D><E><A><L><R><C><K><T><R><I><L><Q><N><D><G><V><V><T><S><P><C><A><R><P><R><K><A><G><H><T><L><L><I><L><G><G><Q><T><F><M><C><D><K><I><Y><Q><V><D><H><K><A><K><E><I><I><P><K><A><D><L><P><S><P><R><K><E><F><S><A><S><A><I><G><C><K><V><Y><V><T><G><G><R><G><S><E><N><G><V><S><K><D><V><W><V><Y><D><T><V><H><E><E><W><S><K><A><A><P><M><L><I><A><R><F><G><H><G><S><A><E><L><E><N><C><L><Y><V><V><G><G><H><T><S><L><A><G><V><F><P><A><S><P><S><V><S><L><K><Q><V><E><K><Y><D><P><G><A><N><K><W><M><M><V><A><P><L><R><D><G><V><S><N><A><A><V><V><S><A><K><L><K><L><F><V><F><G><G><T><S><I><H><R><D><M><V><S><K><V><Q><C><Y><D><P><S><E><N><R><W><T><I><K><A><E><C><P><Q><P><W><R><Y><T><A><A><A><V><L><G><S><Q><I><F><I><M><G><G><D><T><E><F><T><A><A><S><A><Y><R><F><D><C><E><T><N><Q><W><T><R><I><G><D><M><T><A><K><R><M><S><C><H><A><L><A><S><G><N><K><L><Y><V><V><G><G><Y><F><G><T><Q><R><C><K><T><L><D><C><Y><D><P><T><S><D><T><W><N><C><I><T><T><V><P><Y><S><L><I><P><T><A><F><V><S><T><W><K><H><L><P><A> | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis . The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low . The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E . The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis . BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells .<BOP> | Q9H0H3 |
A8MZH6 | OOSP1_HUMAN | Putative oocyte-secreted protein 1 homolog | Homo | <M><K><T><I><L><G><F><K><G><L><F><Y><L><H><S><L><I><W><T><C><A><G><D><W><S><A><I><Q><V><H><C><T><Q><F><W><F><F><A><R><I><K><P><T><I><F><Y><N><L><Y><V><N><P><D><E><V><F><L><G><D><G><C><H><V><T><H><V><L><P><N><V><Y><Y><E><F><F><Y><H><P><H><D><C><G><I><V><T><Q><P><L><Q><E><V><L><L><L><K><T><K><I><R><Y><I><S><R><D><S><T><V><R><S><E><M><P><L><S><C><V><V><H><K><Q><K><C><Q> | May be involved in cell differentiation.<BOP> | A8MZH6 |
Q16270 | IBP7_HUMAN | Tumor-derived adhesion factor | Homo | <M><E><R><P><S><L><R><A><L><L><L><G><A><A><G><L><L><L><L><L><L><P><L><S><S><S><S><S><S><D><T><C><G><P><C><E><P><A><S><C><P><P><L><P><P><L><G><C><L><L><G><E><T><R><D><A><C><G><C><C><P><M><C><A><R><G><E><G><E><P><C><G><G><G><G><A><G><R><G><Y><C><A><P><G><M><E><C><V><K><S><R><K><R><R><K><G><K><A><G><A><A><A><G><G><P><G><V><S><G><V><C><V><C><K><S><R><Y><P><V><C><G><S><D><G><T><T><Y><P><S><G><C><Q><L><R><A><A><S><Q><R><A><E><S><R><G><E><K><A><I><T><Q><V><S><K><G><T><C><E><Q><G><P><S><I><V><T><P><P><K><D><I><W><N><V><T><G><A><Q><V><Y><L><S><C><E><V><I><G><I><P><T><P><V><L><I><W><N><K><V><K><R><G><H><Y><G><V><Q><R><T><E><L><L><P><G><D><R><D><N><L><A><I><Q><T><R><G><G><P><E><K><H><E><V><T><G><W><V><L><V><S><P><L><S><K><E><D><A><G><E><Y><E><C><H><A><S><N><S><Q><G><Q><A><S><A><S><A><K><I><T><V><V><D><A><L><H><E><I><P><V><K><K><G><E><G><A><E><L> | Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.<BOP> | Q16270 |
Q53FT3 | HIKES_HUMAN | Protein Hikeshi | Homo | <M><F><G><C><L><V><A><G><R><L><V><Q><T><A><A><Q><Q><V><A><E><D><K><F><V><F><D><L><P><D><Y><E><S><I><N><H><V><V><V><F><M><L><G><T><I><P><F><P><E><G><M><G><G><S><V><Y><F><S><Y><P><D><S><N><G><M><P><V><W><Q><L><L><G><F><V><T><N><G><K><P><S><A><I><F><K><I><S><G><L><K><S><G><E><G><S><Q><H><P><F><G><A><M><N><I><V><R><T><P><S><V><A><Q><I><G><I><S><V><E><L><L><D><S><M><A><Q><Q><T><P><V><G><N><A><A><V><S><S><V><D><S><F><T><Q><F><T><Q><K><M><L><D><N><F><Y><N><F><A><S><S><F><A><V><S><Q><A><Q><M><T><P><S><P><S><E><M><F><I><P><A><N><V><V><L><K><W><Y><E><N><F><Q><R><R><L><A><Q><N><P><L><F><W><K><T> | Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.<BOP> | Q53FT3 |
O95340 | PAPS2_HUMAN | Adenylylsulfate 3'-phosphotransferase | Homo | <M><S><G><I><K><K><Q><K><T><E><N><Q><Q><K><S><T><N><V><V><Y><Q><A><H><H><V><S><R><N><K><R><G><Q><V><V><G><T><R><G><G><F><R><G><C><T><V><W><L><T><G><L><S><G><A><G><K><T><T><I><S><F><A><L><E><E><Y><L><V><S><H><A><I><P><C><Y><S><L><D><G><D><N><V><R><H><G><L><N><R><N><L><G><F><S><P><G><D><R><E><E><N><I><R><R><I><A><E><V><A><K><L><F><A><D><A><G><L><V><C><I><T><S><F><I><S><P><F><A><K><D><R><E><N><A><R><K><I><H><E><S><A><G><L><P><F><F><E><I><F><V><D><A><P><L><N><I><C><E><S><R><D><V><K><G><L><Y><K><R><A><R><A><G><E><I><K><G><F><T><G><I><D><S><D><Y><E><K><P><E><T><P><E><R><V><L><K><T><N><L><S><T><V><S><D><C><V><H><Q><V><V><E><L><L><Q><E><Q><N><I><V><P><Y><T><I><I><K><D><I><H><E><L><F><V><P><E><N><K><L><D><H><V><R><A><E><A><E><T><L><P><S><L><S><I><T><K><L><D><L><Q><W><V><Q><V><L><S><E><G><W><A><T><P><L><K><G><F><M><R><E><K><E><Y><L><Q><V><M><H><F><D><T><L><L><D><D><G><V><I><N><M><S><I><P><I><V><L><P><V><S><A><E><D><K><T><R><L><E><G><C><S><K><F><V><L><A><H><G><G><R><R><V><A><I><L><R><D><A><E><F><Y><E><H><R><K><E><E><R><C><S><R><V><W><G><T><T><C><T><K><H><P><H><I><K><M><V><M><E><S><G><D><W><L><V><G><G><D><L><Q><V><L><E><K><I><R><W><N><D><G><L><D><Q><Y><R><L><T><P><L><E><L><K><Q><K><C><K><E><M><N><A><D><A><V><F><A><F><Q><L><R><N><P><V><H><N><G><H><A><L><L><M><Q><D><T><R><R><R><L><L><E><R><G><Y><K><H><P><V><L><L><L><H><P><L><G><G><W><T><K><D><D><D><V><P><L><D><W><R><M><K><Q><H><A><A><V><L><E><E><G><V><L><D><P><K><S><T><I><V><A><I><F><P><S><P><M><L><Y><A><G><P><T><E><V><Q><W><H><C><R><S><R><M><I><A><G><A><N><F><Y><I><V><G><R><D><P><A><G><M><P><H><P><E><T><K><K><D><L><Y><E><P><T><H><G><G><K><V><L><S><M><A><P><G><L><T><S><V><E><I><I><P><F><R><V><A><A><Y><N><K><A><K><K><A><M><D><F><Y><D><P><A><R><H><N><E><F><D><F><I><S><G><T><R><M><R><K><L><A><R><E><G><E><N><P><P><D><G><F><M><A><P><K><A><W><K><V><L><T><D><Y><Y><R><S><L><E><K><N> | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases . In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway . Plays indirectly an important role in skeletogenesis during postnatal growth .<BOP> | O95340 |
Q96P15 | SPB11_HUMAN | Serpin B11 | Homo | <M><G><S><L><S><T><A><N><V><E><F><C><L><D><V><F><K><E><L><N><S><N><N><I><G><D><N><I><F><F><S><S><L><S><L><L><Y><A><L><S><M><V><L><L><G><A><R><G><E><T><A><E><Q><L><E><K><V><L><H><F><S><H><T><V><D><S><L><K><P><G><F><K><D><S><P><K><C><S><Q><A><G><R><I><H><S><E><F><G><V><E><F><S><Q><I><N><Q><P><D><S><N><C><T><L><S><I><A><N><R><L><Y><G><T><K><T><M><A><F><H><Q><Q><Y><L><S><C><S><E><K><W><Y><Q><A><R><L><Q><T><V><D><F><E><Q><S><T><E><E><T><R><K><M><I><N><A><W><V><E><N><K><T><N><G><K><V><A><N><L><F><G><K><S><T><I><D><P><S><S><V><M><V><L><V><N><I><I><Y><F><K><G><Q><R><Q><N><K><F><Q><V><R><E><T><V><K><S><P><F><Q><L><S><E><G><K><N><V><T><V><E><M><M><Y><Q><I><G><T><F><K><L><A><F><V><K><E><P><Q><M><Q><V><L><E><L><P><Y><V><N><N><K><L><S><M><I><I><L><L><P><V><G><I><A><N><L><K><Q><I><E><K><Q><L><N><S><G><T><F><H><E><W><T><S><S><S><N><M><M><E><R><E><V><E><V><H><L><P><R><F><K><L><E><I><K><Y><E><L><N><S><L><L><K><P><L><G><V><T><D><L><F><N><Q><V><K><A><D><L><S><G><M><S><P><T><K><G><L><Y><L><S><K><A><I><H><K><S><Y><L><D><V><S><E><E><G><T><E><A><A><A><A><T><G><D><S><I><A><V><K><S><L><P><M><R><A><Q><F><K><A><N><H><P><F><L><F><F><I><R><H><T><H><T><N><T><I><L><F><C><G><K><L><A><S><P> | Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change.<BOP> | Q96P15 |
A1A519 | F170A_HUMAN | Zinc finger protein ZNFD | Homo | <M><K><R><R><Q><K><R><K><H><L><E><N><E><E><S><Q><E><T><A><E><K><G><G><G><M><S><K><S><Q><E><D><A><L><Q><P><G><S><T><R><V><A><K><G><W><S><Q><G><V><G><E><V><T><S><T><S><E><Y><C><S><C><V><S><S><S><R><K><L><I><H><S><G><I><Q><R><I><H><R><D><S><P><Q><P><Q><S><P><L><A><Q><V><Q><E><R><G><E><T><P><P><R><S><Q><H><V><S><L><S><S><Y><S><S><Y><K><T><C><V><S><S><L><C><V><N><K><E><E><R><G><M><K><I><Y><Y><M><Q><V><Q><M><N><K><G><V><A><V><S><W><E><T><E><E><T><L><E><S><L><E><K><Q><P><R><M><E><E><V><T><L><S><E><V><V><R><V><G><T><P><P><S><D><V><S><T><R><N><L><L><S><D><S><E><P><S><G><E><E><K><E><H><E><E><R><T><E><S><D><S><L><P><G><S><P><T><V><E><D><T><P><R><A><K><T><P><D><W><L><V><T><M><E><N><G><F><R><C><M><A><C><C><R><V><F><T><T><M><E><A><L><Q><E><H><V><Q><F><G><I><R><E><G><F><S><C><H><V><F><H><L><T><M><A><Q><L><T><G><N><M><E><S><E><S><T><Q><D><E><Q><E><E><E><N><G><N><E><K><E><E><E><E><K><P><E><A><K><E><E><E><G><Q><P><T><E><E><D><L><G><L><R><R><S><W><S><Q><C><P><G><C><V><F><H><S><P><K><D><R><N><S> | Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE).<BOP> | A1A519 |
P47900 | P2RY1_HUMAN | Purinergic receptor | Homo | <M><T><E><V><L><W><P><A><V><P><N><G><T><D><A><A><F><L><A><G><P><G><S><S><W><G><N><S><T><V><A><S><T><A><A><V><S><S><S><F><K><C><A><L><T><K><T><G><F><Q><F><Y><Y><L><P><A><V><Y><I><L><V><F><I><I><G><F><L><G><N><S><V><A><I><W><M><F><V><F><H><M><K><P><W><S><G><I><S><V><Y><M><F><N><L><A><L><A><D><F><L><Y><V><L><T><L><P><A><L><I><F><Y><Y><F><N><K><T><D><W><I><F><G><D><A><M><C><K><L><Q><R><F><I><F><H><V><N><L><Y><G><S><I><L><F><L><T><C><I><S><A><H><R><Y><S><G><V><V><Y><P><L><K><S><L><G><R><L><K><K><K><N><A><I><C><I><S><V><L><V><W><L><I><V><V><V><A><I><S><P><I><L><F><Y><S><G><T><G><V><R><K><N><K><T><I><T><C><Y><D><T><T><S><D><E><Y><L><R><S><Y><F><I><Y><S><M><C><T><T><V><A><M><F><C><V><P><L><V><L><I><L><G><C><Y><G><L><I><V><R><A><L><I><Y><K><D><L><D><N><S><P><L><R><R><K><S><I><Y><L><V><I><I><V><L><T><V><F><A><V><S><Y><I><P><F><H><V><M><K><T><M><N><L><R><A><R><L><D><F><Q><T><P><A><M><C><A><F><N><D><R><V><Y><A><T><Y><Q><V><T><R><G><L><A><S><L><N><S><C><V><D><P><I><L><Y><F><L><A><G><D><T><F><R><R><R><L><S><R><A><T><R><K><A><S><R><R><S><E><A><N><L><Q><S><K><S><E><D><M><T><L><N><I><L><P><E><F><K><Q><N><G><D><T><S><L> | Receptor for extracellular adenine nucleotides such as ADP . In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation .<BOP> | P47900 |
Q13868 | EXOS2_HUMAN | Ribosomal RNA-processing protein 4 | Homo | <M><A><M><E><M><R><L><P><V><A><R><K><P><L><S><E><R><L><G><R><D><T><K><K><H><L><V><V><P><G><D><T><I><T><T><D><T><G><F><M><R><G><H><G><T><Y><M><G><E><E><K><L><I><A><S><V><A><G><S><V><E><R><V><N><K><L><I><C><V><K><A><L><K><T><R><Y><I><G><E><V><G><D><I><V><V><G><R><I><T><E><V><Q><Q><K><R><W><K><V><E><T><N><S><R><L><D><S><V><L><L><L><S><S><M><N><L><P><G><G><E><L><R><R><R><S><A><E><D><E><L><A><M><R><G><F><L><Q><E><G><D><L><I><S><A><E><V><Q><A><V><F><S><D><G><A><V><S><L><H><T><R><S><L><K><Y><G><K><L><G><Q><G><V><L><V><Q><V><S><P><S><L><V><K><R><Q><K><T><H><F><H><D><L><P><C><G><A><S><V><I><L><G><N><N><G><F><I><W><I><Y><P><T><P><E><H><K><E><E><E><A><G><G><F><I><A><N><L><E><P><V><S><L><A><D><R><E><V><I><S><R><L><R><N><C><I><I><S><L><V><T><Q><R><M><M><L><Y><D><T><S><I><L><Y><C><Y><E><A><S><L><P><H><Q><I><K><D><I><L><K><P><E><I><M><E><E><I><V><M><E><T><R><Q><R><L><L><E><Q><E><G> | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Ex | Q13868 |
Q9BR84 | ZN559_HUMAN | Zinc finger protein 559 | Homo | <M><V><A><G><W><L><T><N><Y><S><Q><D><S><V><T><F><E><D><V><A><V><D><F><T><Q><E><E><W><T><L><L><D><Q><T><Q><R><N><L><Y><R><D><V><M><L><E><N><Y><K><N><L><V><A><V><D><W><E><S><H><I><N><T><K><W><S><A><P><Q><Q><N><F><L><Q><G><K><T><S><S><V><V><E><M><E><R><N><H><F><G><E><E><L><F><D><F><N><Q><C><E><K><A><L><S><E><H><S><C><L><K><T><H><R><R><T><Y><F><R><K><K><T><C><E><C><N><Q><C><E><K><A><F><R><K><P><S><I><F><T><L><H><K><K><T><D><I><G><E><E><L><P><N><C><N><Q><C><E><T><A><F><S><Q><H><L><H><L><V><C><K><K><T><S><Q><N><L><H><L><V><C><K><K><T><H><T><Q><E><K><P><Y><K><C><S><D><C><E><K><G><L><P><S><S><S><H><L><R><E><C><V><R><I><Y><G><G><E><R><P><Y><T><H><K><E><Y><V><E><T><F><S><H><S><T><A><L><F><V><H><M><Q><T><Q><D><G><E><K><F><Y><E><C><K><A><C><G><K><P><F><T><E><S><S><Y><L><T><Q><H><L><R><T><H><S><R><V><L><P><I><E><H><K><K><F><G><K><A><F><A><F><S><P><D><L><A><K><H><I><R><L><R><T><R><G><K><H><Y><V><C><N><E><C><G><K><E><F><T><C><F><S><K><L><N><I><H><I><R><V><H><T><G><E><K><P><Y><E><C><N><K><C><G><K><A><F><T><D><S><S><G><L><I><K><H><R><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><A><N><S><S><H><L><T><V><H><M><R><T><H><T><G><E><K><P><Y><Q><C><K><E><C><G><K><A><F><I><N><S><S><S><F><K><S><H><M><Q><T><H><P><G><V><K><P><Y><D><C><Q><Q><C><G><K><A><F><I><R><S><S><F><L><I><R><H><L><R><S><H><S><A><E><R><P><F><E><C><E><E><C><G><K><A><F><R><Y><S><S><H><L><S><Q><H><K><R><I><H><T><G><E><R><P><Y><K><C><Q><K><C><G><Q><A><F><S><I><S><S><G><L><T><V><H><M><R><T><H><T><G><E><R><P><F><E><C><Q><E><C><G><K><A><F><T><R><S><T><Y><L><I><R><H><L><R><S><H><S><V><E><K><P><Y><K><E><C><G><Q><T><F><S><N><S><S><C><L><T><E><C><V> | May be involved in transcriptional regulation.<BOP> | Q9BR84 |
A0A1B0GTH6 | CS2IP_HUMAN | Casein kinase II subunit alpha'-interacting protein | Homo | <M><V><P><L><A><Y><Y><G><Q><H><F><V><P><L><D><Y><F><Y><Q><L><S><S><A><N><T><L><T><H><Q><H><T><G><E><K><L><N><Q><F><N><N><Q><P><M><A><K><V><Q><S><H><S><N><H><F><A><V><P><P><L><G><S><N><K><K><V><Q><R><C><S><V><L><P><S><P><K><S><Q><D><K><I><S><Q><S><F><C><D><R><F><L><N><S><P><L><F><H><A><K><H><Q><N><T><P><S><I><G><L><H><W><R><S><S><L><W><P><A><Q><R><A><L><N><S><H><L><L><H><S><K><A><Q><T><T><S><S><S><D><L><N><M><T><S><S><L><E><L><N><Q><A><A><L><S><L><Q><L><P><F><C><K><P><Q><T><T><S><S><S><L><D><V><C><W><R><S><L><S><L><K><S><H><Q><R><V><S><S><S><S><L><F><R><L><Q><N><Q><E><I><P><S><I><N><I><I><W><T><S><S><S><L><G><P><K><R><K><A><L><S><S><T><L><L><Q><S><K><P><Q><K><T><S><S><L><D><Y><L><W><T><S><S><L><Q><R><N><Q><R><S><L><S><S><P><S><L><N><T><K><L><Q><T><S><D><L><F><W><T><S><P><S><F><K><P><N><Q><I><A><L><T><S><P><L><L><D><S><R><L><Q><K><T><P><I><L><N><S><N><P><T><I><G><G><L><P><V><S><H><S><K><A><R><Q><S><A><S><S><Y><F><V><H><P><S><E><N><L><P><L><F><Q><L><N><S><Q><S><M><F><M><L><D><C><N><F><Q><T><T><N><S><P><V><C><H><S><K><F><Q><N><T><T><S><P><N><G><K><H><R><V><T><H><L><P><S><P><H><P><K><T><N><I><S><G><Q><L><L><S><S><S><K><H><C><T><R><N><T><A><A><S><T><L><G><F><R><L><Q><S><K><S><S><F><Q><F><S><P><K><T><E><S><N><K><E><I><P><W><T><L><K><Y><S><Q><P><C><I><V><K><G><G><T><V><P><D><D><V><V><N><K><I><V><N><S><I><S><N><T><R><I><Q><R><D><L><C><R><Q><I><L><F><R><R><M><R><G><R><P><N><P><H><P><G><P><R><L><S><S><N><Y><V><V><C><L><A><C><A><S><C><L><K><S><P><C><N><H><L><R><G><K><K><N><P><H><C><A><T><L><S><V><I><P><T><P><E><A><N><S><E><G><K><I><E><V><K><L><V><L><I><L><S><L><P><E><T><F><S><S><C><L><P><F><P><M><K><E><N><Q><P><N><E><V><P><E><D><N><L><E><G><V><E><K><I><Q><Q><F><F><P><T><S><E><R><D><I><Q><G><L><N><M><K><Q><I><W><W><A><V><A><P><E><N><K><V><I><G><Q><Q><P><Q><A><I><D><W><L><F><Y><V><K><K><N><N><S><Q><P><Q><S><L><L><P><S><T><S><S><S><T><S><S><S><S><T><T><S><S><S><S><S><V><A><S><A><S><S><D><S><S><S><S><S><S><S><S><S><S><F><S><I><S><S><S><S><S><P><S><K><E><F><M><T><L><T><L><S><R><P><V><F><R><K><V><L><S><Y><H><R><L><P><A><G><V><S><W><L><E><F><I><Y><S><K><D><Y><Q><L><H><P><R><K><P><N><R><S><Q><S><S><S><L><K><T><K><P><V><R><N><N><N><T><V><K><W><R><K><G><A><N><T><L><F><K><F><F><R><T><K> | May play a role in chromatin regulation of male germ cells.<BOP> | A0A1B0GTH6 |
P46779 | RL28_HUMAN | Large ribosomal subunit protein eL28 | Homo | <M><S><A><H><L><Q><W><M><V><V><R><N><C><S><S><F><L><I><K><R><N><K><Q><T><Y><S><T><E><P><N><N><L><K><A><R><N><S><F><R><Y><N><G><L><I><H><R><K><T><V><G><V><E><P><A><A><D><G><K><G><V><V><V><V><I><K><R><R><S><G><Q><R><K><P><A><T><S><Y><V><R><T><T><I><N><K><N><A><R><A><T><L><S><S><I><R><H><M><I><R><K><N><K><Y><R><P><D><L><R><M><A><A><I><R><R><A><S><A><I><L><R><S><Q><K><P><V><M><V><K><R><K><R><T><R><P><T><K><S><S> | Component of the large ribosomal subunit . The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell .<BOP> | P46779 |
O94905 | ERLN2_HUMAN | Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 | Homo | <M><A><Q><L><G><A><V><V><A><V><A><S><S><F><F><C><A><S><L><F><S><A><V><H><K><I><E><E><G><H><I><G><V><Y><Y><R><G><G><A><L><L><T><S><T><S><G><P><G><F><H><L><M><L><P><F><I><T><S><Y><K><S><V><Q><T><T><L><Q><T><D><E><V><K><N><V><P><C><G><T><S><G><G><V><M><I><Y><F><D><R><I><E><V><V><N><F><L><V><P><N><A><V><Y><D><I><V><K><N><Y><T><A><D><Y><D><K><A><L><I><F><N><K><I><H><H><E><L><N><Q><F><C><S><V><H><T><L><Q><E><V><Y><I><E><L><F><D><Q><I><D><E><N><L><K><L><A><L><Q><Q><D><L><T><S><M><A><P><G><L><V><I><Q><A><V><R><V><T><K><P><N><I><P><E><A><I><R><R><N><Y><E><L><M><E><S><E><K><T><K><L><L><I><A><A><Q><K><Q><K><V><V><E><K><E><A><E><T><E><R><K><K><A><L><I><E><A><E><K><V><A><Q><V><A><E><I><T><Y><G><Q><K><V><M><E><K><E><T><E><K><K><I><S><E><I><E><D><A><A><F><L><A><R><E><K><A><K><A><D><A><E><C><Y><T><A><M><K><I><A><E><A><N><K><L><K><L><T><P><E><Y><L><Q><L><M><K><Y><K><A><I><A><S><N><S><K><I><Y><F><G><K><D><I><P><N><M><F><M><D><S><A><G><S><V><S><K><Q><F><E><G><L><A><D><K><L><S><F><G><L><E><D><E><P><L><E><T><A><T><K><E><N> | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 . Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex . Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex .<BOP> | O94905 |
P12694 | ODBA_HUMAN | Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain | Homo | <M><A><V><A><I><A><A><A><R><V><W><R><L><N><R><G><L><S><Q><A><A><L><L><L><L><R><Q><P><G><A><R><G><L><A><R><S><H><P><P><R><Q><Q><Q><Q><F><S><S><L><D><D><K><P><Q><F><P><G><A><S><A><E><F><I><D><K><L><E><F><I><Q><P><N><V><I><S><G><I><P><I><Y><R><V><M><D><R><Q><G><Q><I><I><N><P><S><E><D><P><H><L><P><K><E><K><V><L><K><L><Y><K><S><M><T><L><L><N><T><M><D><R><I><L><Y><E><S><Q><R><Q><G><R><I><S><F><Y><M><T><N><Y><G><E><E><G><T><H><V><G><S><A><A><A><L><D><N><T><D><L><V><F><G><Q><Y><R><E><A><G><V><L><M><Y><R><D><Y><P><L><E><L><F><M><A><Q><C><Y><G><N><I><S><D><L><G><K><G><R><Q><M><P><V><H><Y><G><C><K><E><R><H><F><V><T><I><S><S><P><L><A><T><Q><I><P><Q><A><V><G><A><A><Y><A><A><K><R><A><N><A><N><R><V><V><I><C><Y><F><G><E><G><A><A><S><E><G><D><A><H><A><G><F><N><F><A><A><T><L><E><C><P><I><I><F><F><C><R><N><N><G><Y><A><I><S><T><P><T><S><E><Q><Y><R><G><D><G><I><A><A><R><G><P><G><Y><G><I><M><S><I><R><V><D><G><N><D><V><F><A><V><Y><N><A><T><K><E><A><R><R><R><A><V><A><E><N><Q><P><F><L><I><E><A><M><T><Y><R><I><G><H><H><S><T><S><D><D><S><S><A><Y><R><S><V><D><E><V><N><Y><W><D><K><Q><D><H><P><I><S><R><L><R><H><Y><L><L><S><Q><G><W><W><D><E><E><Q><E><K><A><W><R><K><Q><S><R><R><K><V><M><E><A><F><E><Q><A><E><R><K><P><K><P><N><P><N><L><L><F><S><D><V><Y><Q><E><M><P><A><Q><L><R><K><Q><Q><E><S><L><A><R><H><L><Q><T><Y><G><E><H><Y><P><L><D><H><F><D><K> | E1 subunit of the branched-chain alpha-keto dehydrogenase complex that catalyzes both the decarboxylation of the alpha-ketoacid and the subsequent reductive acylation of the lipoyl moiety (another catalytic cofactor) that is covalently bound to E2 . The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).<BOP> | P12694 |
Q9P2N7 | KLH13_HUMAN | BTB and kelch domain-containing protein 2 | Homo | <M><P><L><K><W><K><T><S><S><P><A><I><W><K><F><P><V><P><V><L><K><T><S><R><S><T><P><L><S><P><A><Y><I><S><L><V><E><E><E><D><Q><H><M><K><L><S><L><G><G><S><E><M><G><L><S><S><H><L><Q><S><S><K><A><G><P><T><R><I><F><T><S><N><T><H><S><S><V><V><L><Q><G><F><D><Q><L><R><L><E><G><L><L><C><D><V><T><L><M><P><G><D><T><D><D><A><F><P><V><H><R><V><M><M><A><S><A><S><D><Y><F><K><A><M><F><T><G><G><M><K><E><Q><D><L><M><C><I><K><L><H><G><V><S><K><V><G><L><R><K><I><I><D><F><I><Y><T><A><K><L><S><L><N><M><D><N><L><Q><D><T><L><E><A><A><S><F><L><Q><I><L><P><V><L><D><F><C><K><V><F><L><I><S><G><V><T><L><D><N><C><V><E><V><G><R><I><A><N><T><Y><N><L><T><E><V><D><K><Y><V><N><S><F><V><L><K><N><F><P><A><L><L><S><T><G><E><F><L><K><L><P><F><E><R><L><A><F><V><L><S><S><N><S><L><K><H><C><T><E><L><E><L><F><K><A><T><C><R><W><L><R><L><E><E><P><R><M><D><F><A><A><K><L><M><K><N><I><R><F><P><L><M><T><P><Q><E><L><I><N><Y><V><Q><T><V><D><F><M><R><T><D><N><T><C><V><N><L><L><L><E><A><S><N><Y><Q><M><M><P><Y><M><Q><P><V><M><Q><S><D><R><T><A><I><R><S><D><T><T><H><L><V><T><L><G><G><V><L><R><Q><Q><L><V><V><S><K><E><L><R><M><Y><D><E><K><A><H><E><W><K><S><L><A><P><M><D><A><P><R><Y><Q><H><G><I><A><V><I><G><N><F><L><Y><V><V><G><G><Q><S><N><Y><D><T><K><G><K><T><A><V><D><T><V><F><R><F><D><P><R><Y><N><K><W><M><Q><V><A><S><L><N><E><K><R><T><F><F><H><L><S><A><L><K><G><Y><L><Y><A><V><G><G><R><N><A><A><G><E><L><P><T><V><E><C><Y><N><P><R><T><N><E><W><T><Y><V><A><K><M><S><E><P><H><Y><G><H><A><G><T><V><Y><G><G><V><M><Y><I><S><G><G><I><T><H><D><T><F><Q><K><E><L><M><C><F><D><P><D><T><D><K><W><I><Q><K><A><P><M><T><T><V><R><G><L><H><C><M><C><T><V><G><E><R><L><Y><V><I><G><G><N><H><F><R><G><T><S><D><Y><D><D><V><L><S><C><E><Y><Y><S><P><I><L><D><Q><W><T><P><I><A><A><M><L><R><G><Q><S><D><V><G><V><A><V><F><E><N><K><I><Y><V><V><G><G><Y><S><W><N><N><R><C><M><V><E><I><V><Q><K><Y><D><P><D><K><D><E><W><H><K><V><F><D><L><P><E><S><L><G><G><I><R><A><C><T><L><T><V><F><P><P><E><E><T><T><P><S><P><S><R><E><S><P><L><S><A><P> | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.<BOP> | Q9P2N7 |
Q9Y6A1 | POMT1_HUMAN | Dolichyl-phosphate-mannose--protein mannosyltransferase 1 | Homo | <M><W><G><F><L><K><R><P><V><V><V><T><A><D><I><N><L><S><L><V><A><L><T><G><M><G><L><L><S><R><L><W><R><L><T><Y><P><R><A><V><V><F><D><E><V><Y><Y><G><Q><Y><I><S><F><Y><M><K><Q><I><F><F><L><D><D><S><G><P><P><F><G><H><M><V><L><A><L><G><G><Y><L><G><G><F><D><G><N><F><L><W><N><R><I><G><A><E><Y><S><S><N><V><P><V><W><S><L><R><L><L><P><A><L><A><G><A><L><S><V><P><M><A><Y><Q><I><V><L><E><L><H><F><S><H><C><A><A><M><G><A><A><L><L><M><L><I><E><N><A><L><I><T><Q><S><R><L><M><L><L><E><S><V><L><I><F><F><N><L><L><A><V><L><S><Y><L><K><F><F><N><C><Q><K><H><S><P><F><S><L><S><W><W><F><W><L><T><L><T><G><V><A><C><S><C><A><V><G><I><K><Y><M><G><V><F><T><Y><V><L><V><L><G><V><A><A><V><H><A><W><H><L><L><G><D><Q><T><L><S><N><V><G><A><D><V><Q><C><C><M><R><P><A><C><M><G><Q><M><Q><M><S><Q><G><V><C><V><F><C><H><L><L><A><R><A><V><A><L><L><V><I><P><V><V><L><Y><L><L><F><F><Y><V><H><L><I><L><V><F><R><S><G><P><H><D><Q><I><M><S><S><A><F><Q><A><S><L><E><G><G><L><A><R><I><T><Q><G><Q><P><L><E><V><A><F><G><S><Q><V><T><L><R><N><V><F><G><K><P><V><P><C><W><L><H><S><H><Q><D><T><Y><P><M><I><Y><E><N><G><R><G><S><S><H><Q><Q><Q><V><T><C><Y><P><F><K><D><V><N><N><W><W><I><V><K><D><P><R><R><H><Q><L><V><V><S><S><P><P><R><P><V><R><H><G><D><M><V><Q><L><V><H><G><M><T><T><R><S><L><N><T><H><D><V><A><A><P><L><S><P><H><S><Q><E><V><S><C><Y><I><D><Y><N><I><S><M><P><A><Q><N><L><W><R><L><E><I><V><N><R><G><S><D><T><D><V><W><K><T><I><L><S><E><V><R><F><V><H><V><N><T><S><A><V><L><K><L><S><G><A><H><L><P><D><W><G><Y><R><Q><L><E><I><V><G><E><K><L><S><R><G><Y><H><G><S><T><V><W><N><V><E><E><H><R><Y><G><A><S><Q><E><Q><R><E><R><E><R><E><L><H><S><P><A><Q><V><D><V><S><R><N><L><S><F><M><A><R><F><S><E><L><Q><W><R><M><L><A><L><R><S><D><D><S><E><H><K><Y><S><S><S><P><L><E><W><V><T><L><D><T><N><I><A><Y><W><L><H><P><R><T><S><A><Q><I><H><L><L><G><N><I><V><I><W><V><S><G><S><L><A><L><A><I><Y><A><L><L><S><L><W><Y><L><L><R><R><R><R><N><V><H><D><L><P><Q><D><A><W><L><R><W><V><L><A><G><A><L><C><A><G><G><W><A><V><N><Y><L><P><F><F><L><M><E><K><T><L><F><L><Y><H><Y><L><P><A><L><T><F><Q><I><L><L><L><P><V><V><L><Q><H><I><S><D><H><L><C><R><S><Q><L><Q><R><S><I><F><S><A><L><V><V><A><W><Y><S><S><A><C><H><V><S><N><T><L><R><P><L><T><Y><G><D><K><S><L><S><P><H><E><L><K><A><L><R><W><K><D><S><W><D><I><L><I><R><K><H> | Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient . Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins .<BOP> | Q9Y6A1 |
Q49AM1 | MTEF2_HUMAN | mTERF domain-containing protein 3, mitochondrial | Homo | <M><L><W><K><L><L><L><R><S><Q><S><C><R><L><C><S><F><R><K><M><R><S><P><P><K><Y><R><P><F><L><A><C><F><T><Y><T><T><D><K><Q><S><S><K><E><N><T><R><T><V><E><K><L><Y><K><C><S><V><D><I><R><K><I><R><R><L><K><G><W><V><L><L><E><D><E><T><Y><V><E><E><I><A><N><I><L><Q><E><L><G><A><D><E><T><A><V><A><S><I><L><E><R><C><P><E><A><I><V><C><S><P><T><A><V><N><T><Q><R><K><L><W><Q><L><V><C><K><N><E><E><E><L><I><K><L><I><E><Q><F><P><E><S><F><F><T><I><K><D><Q><E><N><Q><K><L><N><V><Q><F><F><Q><E><L><G><L><K><N><V><V><I><S><R><L><L><T><A><A><P><N><V><F><H><N><P><V><E><K><N><K><Q><M><V><R><I><L><Q><E><S><Y><L><D><V><G><G><S><E><A><N><M><K><V><W><L><L><K><L><L><S><Q><N><P><F><I><L><L><N><S><P><T><A><I><K><E><T><L><E><F><L><Q><E><Q><G><F><T><S><F><E><I><L><Q><L><L><S><K><L><K><G><F><L><F><Q><L><C><P><R><S><I><Q><N><S><I><S><F><S><K><N><A><F><K><C><T><D><H><D><L><K><Q><L><V><L><K><C><P><A><L><L><Y><Y><S><V><P><V><L><E><E><R><M><Q><G><L><L><R><E><G><I><S><I><A><Q><I><R><E><T><P><M><V><L><E><L><T><P><Q><I><V><Q><Y><R><I><R><K><L><N><S><S><G><Y><R><I><K><D><G><H><L><A><N><L><N><G><S><K><K><E><F><E><A><N><F><G><K><I><Q><A><K><K><V><R><P><L><F><N><P><V><A><P><L><N><V><E><E> | Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species.<BOP> | Q49AM1 |
Q5TCH4 | CP4AM_HUMAN | Long-chain fatty acid omega-monooxygenase | Homo | <M><S><V><S><V><L><S><P><S><R><R><L><G><G><V><S><G><I><L><Q><V><T><S><L><L><I><L><L><L><L><L><I><K><A><A><Q><L><Y><L><H><R><Q><W><L><L><K><A><L><Q><Q><F><P><C><P><P><S><H><W><L><F><G><H><I><Q><E><F><Q><H><D><Q><E><L><Q><R><I><Q><E><R><V><K><T><F><P><S><A><C><P><Y><W><I><W><G><G><K><V><R><V><Q><L><Y><D><P><D><Y><M><K><V><I><L><G><R><S><D><P><K><S><H><G><S><Y><K><F><L><A><P><R><I><G><Y><G><L><L><L><L><N><G><Q><T><W><F><Q><H><R><R><M><L><T><P><A><F><H><N><D><I><L><K><P><Y><V><G><L><M><A><D><S><V><R><V><M><L><D><K><W><E><E><L><L><G><Q><D><S><P><L><E><V><F><Q><H><V><S><L><M><T><L><D><T><I><M><K><S><A><F><S><H><Q><G><S><I><Q><V><D><R><N><S><Q><S><Y><I><Q><A><I><S><D><L><N><S><L><V><F><C><C><M><R><N><A><F><H><E><N><D><T><I><Y><S><L><T><S><A><G><R><W><T><H><R><A><C><Q><L><A><H><Q><H><T><D><Q><V><I><Q><L><R><K><A><Q><L><Q><K><E><G><E><L><E><K><I><K><R><K><R><H><L><D><F><L><D><I><L><L><L><A><K><M><E><N><G><S><I><L><S><D><K><D><L><R><A><E><V><D><T><F><M><F><E><G><H><D><T><T><A><S><G><I><S><W><I><L><Y><A><L><A><T><H><P><K><H><Q><E><R><C><R><E><E><I><H><G><L><L><G><D><G><A><S><I><T><W><N><H><L><D><Q><M><P><Y><T><T><M><C><I><K><E><A><L><R><L><Y><P><P><V><P><G><I><G><R><E><L><S><T><P><V><T><F><P><D><G><R><S><L><P><K><G><I><M><V><L><L><S><I><Y><G><L><H><H><N><P><K><V><W><P><N><L><E><V><F><D><P><S><R><F><A><P><G><S><A><Q><H><S><H><A><F><L><P><F><S><G><G><S><R><N><C><I><G><K><Q><F><A><M><N><Q><L><K><V><A><R><A><L><T><L><L><R><F><E><L><L><P><D><P><T><R><I><P><I><P><M><A><R><L><V><L><K><S><K><N><G><I><H><L><R><L><R><R><L><P><N><P><C><E><D><K><D><Q><L> | Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis.<BOP> | Q5TCH4 |
Q8TAE7 | KCNG3_HUMAN | Voltage-gated potassium channel subunit Kv6.3 | Homo | <M><T><F><G><R><S><G><A><A><S><V><V><L><N><V><G><G><A><R><Y><S><L><S><R><E><L><L><K><D><F><P><L><R><R><V><S><R><L><H><G><C><R><S><E><R><D><V><L><E><V><C><D><D><Y><D><R><E><R><N><E><Y><F><F><D><R><H><S><E><A><F><G><F><I><L><L><Y><V><R><G><H><G><K><L><R><F><A><P><R><M><C><E><L><S><F><Y><N><E><M><I><Y><W><G><L><E><G><A><H><L><E><Y><C><C><Q><R><R><L><D><D><R><M><S><D><T><Y><T><F><Y><S><A><D><E><P><G><V><L><G><R><D><E><A><R><P><G><G><A><E><A><A><P><S><R><R><W><L><E><R><M><R><R><T><F><E><E><P><T><S><S><L><A><A><Q><I><L><A><S><V><S><V><V><F><V><I><V><S><M><V><V><L><C><A><S><T><L><P><D><W><R><N><A><A><A><D><N><R><S><L><D><D><R><S><R><Y><S><A><G><P><G><R><E><P><S><G><I><I><E><A><I><C><I><G><W><F><T><A><E><C><I><V><R><F><I><V><S><K><N><K><C><E><F><V><K><R><P><L><N><I><I><D><L><L><A><I><T><P><Y><Y><I><S><V><L><M><T><V><F><T><G><E><N><S><Q><L><Q><R><A><G><V><T><L><R><V><L><R><M><M><R><I><F><W><V><I><K><L><A><R><H><F><I><G><L><Q><T><L><G><L><T><L><K><R><C><Y><R><E><M><V><M><L><L><V><F><I><C><V><A><M><A><I><F><S><A><L><S><Q><L><L><E><H><G><L><D><L><E><T><S><N><K><D><F><T><S><I><P><A><A><C><W><W><V><I><I><S><M><T><T><V><G><Y><G><D><M><Y><P><I><T><V><P><G><R><I><L><G><G><V><C><V><V><S><G><I><V><L><L><A><L><P><I><T><F><I><Y><H><S><F><V><Q><C><Y><H><E><L><K><F><R><S><A><R><Y><S><R><S><L><S><T><E><F><L><N> | Potassium channel subunit that does not form functional channels by itself . Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 .<BOP> | Q8TAE7 |
Q70CQ1 | UBP49_HUMAN | Ubiquitin-specific-processing protease 49 | Homo | <M><D><R><C><K><H><V><G><R><L><R><L><A><Q><D><H><S><I><L><N><P><Q><K><W><C><C><L><E><C><A><T><T><E><S><V><W><A><C><L><K><C><S><H><V><A><C><G><R><Y><I><E><D><H><A><L><K><H><F><E><E><T><G><H><P><L><A><M><E><V><R><D><L><Y><V><F><C><Y><L><C><K><D><Y><V><L><N><D><N><P><E><G><D><L><K><L><L><R><S><S><L><L><A><V><R><G><Q><K><Q><D><T><P><V><R><R><G><R><T><L><R><S><M><A><S><G><E><D><V><V><L><P><Q><R><A><P><Q><G><Q><P><Q><M><L><T><A><L><W><Y><R><R><Q><R><L><L><A><R><T><L><R><L><W><F><E><K><S><S><R><G><Q><A><K><L><E><Q><R><R><Q><E><E><A><L><E><R><K><K><E><E><A><R><R><R><R><R><E><V><K><R><R><L><L><E><E><L><A><S><T><P><P><R><K><S><A><R><L><L><L><H><T><P><R><D><A><G><P><A><A><S><R><P><A><A><L><P><T><S><R><R><V><P><A><A><T><L><K><L><R><R><Q><P><A><M><A><P><G><V><T><G><L><R><N><L><G><N><T><C><Y><M><N><S><I><L><Q><V><L><S><H><L><Q><K><F><R><E><C><F><L><N><L><D><P><S><K><T><E><H><L><F><P><K><A><T><N><G><K><T><Q><L><S><G><K><P><T><N><S><S><A><T><E><L><S><L><R><N><D><R><A><E><A><C><E><R><E><G><F><C><W><N><G><R><A><S><I><S><R><S><L><E><L><I><Q><N><K><E><P><S><S><K><H><I><S><L><C><R><E><L><H><T><L><F><R><V><M><W><S><G><K><W><A><L><V><S><P><F><A><M><L><H><S><V><W><S><L><I><P><A><F><R><G><Y><D><Q><Q><D><A><Q><E><F><L><C><E><L><L><H><K><V><Q><Q><E><L><E><S><E><G><T><T><R><R><I><L><I><P><F><S><Q><R><K><L><T><K><Q><V><L><K><V><V><N><T><I><F><H><G><Q><L><L><S><Q><V><T><C><I><S><C><N><Y><K><S><N><T><I><E><P><F><W><D><L><S><L><E><F><P><E><R><Y><H><C><I><E><K><G><F><V><P><L><N><Q><T><E><C><L><L><T><E><M><L><A><K><F><T><E><T><E><A><L><E><G><R><I><Y><A><C><D><Q><C><N><S><K><R><R><K><S><N><P><K><P><L><V><L><S><E><A><R><K><Q><L><M><I><Y><R><L><P><Q><V><L><R><L><H><L><K><R><F><R><W><S><G><R><N><H><R><E><K><I><G><V><H><V><V><F><D><Q><V><L><T><M><E><P><Y><C><C><R><D><M><L><S><S><L><D><K><E><T><F><A><Y><D><L><S><A><V><V><M><H><H><G><K><G><F><G><S><G><H><Y><T><A><Y><C><Y><N><T><E><G><G><F><W><V><H><C><N><D><S><K><L><N><V><C><S><V><E><E><V><C><K><T><Q><A><Y><I><L><F><Y><T><Q><R><T><V><Q><G><N><A><R><I><S><E><T><H><L><Q><A><Q><V><Q><S><S><N><N><D><E><G><R><P><Q><T><F><S> | Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.<BOP> | Q70CQ1 |
Q8N1Q1 | CAH13_HUMAN | Carbonic anhydrase XIII | Homo | <M><S><R><L><S><W><G><Y><R><E><H><N><G><P><I><H><W><K><E><F><F><P><I><A><D><G><D><Q><Q><S><P><I><E><I><K><T><K><E><V><K><Y><D><S><S><L><R><P><L><S><I><K><Y><D><P><S><S><A><K><I><I><S><N><S><G><H><S><F><N><V><D><F><D><D><T><E><N><K><S><V><L><R><G><G><P><L><T><G><S><Y><R><L><R><Q><V><H><L><H><W><G><S><A><D><D><H><G><S><E><H><I><V><D><G><V><S><Y><A><A><E><L><H><V><V><H><W><N><S><D><K><Y><P><S><F><V><E><A><A><H><E><P><D><G><L><A><V><L><G><V><F><L><Q><I><G><E><P><N><S><Q><L><Q><K><I><T><D><T><L><D><S><I><K><E><K><G><K><Q><T><R><F><T><N><F><D><L><L><S><L><L><P><P><S><W><D><Y><W><T><Y><P><G><S><L><T><V><P><P><L><L><E><S><V><T><W><I><V><L><K><Q><P><I><N><I><S><S><Q><Q><L><A><K><F><R><S><L><L><C><T><A><E><G><E><A><A><A><F><L><V><S><N><H><R><P><P><Q><P><L><K><G><R><K><V><R><A><S><F><H> | Reversible hydration of carbon dioxide.<BOP> | Q8N1Q1 |
P19256 | LFA3_HUMAN | Surface glycoprotein LFA-3 | Homo | <M><V><A><G><S><D><A><G><R><A><L><G><V><L><S><V><V><C><L><L><H><C><F><G><F><I><S><C><F><S><Q><Q><I><Y><G><V><V><Y><G><N><V><T><F><H><V><P><S><N><V><P><L><K><E><V><L><W><K><K><Q><K><D><K><V><A><E><L><E><N><S><E><F><R><A><F><S><S><F><K><N><R><V><Y><L><D><T><V><S><G><S><L><T><I><Y><N><L><T><S><S><D><E><D><E><Y><E><M><E><S><P><N><I><T><D><T><M><K><F><F><L><Y><V><L><E><S><L><P><S><P><T><L><T><C><A><L><T><N><G><S><I><E><V><Q><C><M><I><P><E><H><Y><N><S><H><R><G><L><I><M><Y><S><W><D><C><P><M><E><Q><C><K><R><N><S><T><S><I><Y><F><K><M><E><N><D><L><P><Q><K><I><Q><C><T><L><S><N><P><L><F><N><T><T><S><S><I><I><L><T><T><C><I><P><S><S><G><H><S><R><H><R><Y><A><L><I><P><I><P><L><A><V><I><T><T><C><I><V><L><Y><M><N><G><I><L><K><C><D><R><K><P><D><R><T><N><S><N> | Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.<BOP> | P19256 |
Q86Y37 | CACL1_HUMAN | Cdk-associated cullin 1 | Homo | <M><E><E><S><M><E><E><E><E><G><G><S><Y><E><A><M><M><D><D><Q><N><H><N><N><W><E><A><A><V><D><G><F><R><Q><P><L><P><P><P><P><P><P><S><S><I><P><A><P><A><R><E><P><P><G><G><Q><L><L><A><V><P><A><V><S><V><D><R><K><G><P><K><E><G><L><P><M><G><P><Q><P><P><P><E><A><N><G><V><I><M><M><L><K><S><C><D><A><A><A><A><V><A><K><A><A><P><A><P><T><A><S><S><T><I><N><I><N><T><S><T><S><K><F><L><M><N><V><I><T><I><E><D><Y><K><S><T><Y><W><P><K><L><D><G><A><I><D><Q><L><L><T><Q><S><P><G><D><Y><I><P><I><S><Y><E><Q><I><Y><S><C><V><Y><K><C><V><C><Q><Q><H><S><E><Q><M><Y><S><D><L><I><K><K><I><T><N><H><L><E><R><V><S><K><E><L><Q><A><S><P><P><D><L><Y><I><E><R><F><N><I><A><L><G><Q><Y><M><G><A><L><Q><S><I><V><P><L><F><I><Y><M><N><K><F><Y><I><E><T><K><L><N><R><D><L><K><D><D><L><I><K><L><F><T><E><H><V><A><E><K><H><I><Y><S><L><M><P><L><L><L><E><A><Q><S><T><P><F><Q><V><T><P><S><T><M><A><N><I><V><K><G><L><Y><T><L><R><P><E><W><V><Q><M><A><P><T><L><F><S><K><F><I><P><N><I><L><P><P><A><V><E><S><E><L><S><E><Y><A><A><Q><D><Q><K><F><Q><R><E><L><I><Q><N><G><F><T><R><G><D><Q><S><R><K><R><A><G><D><E><L><A><Y><N><S><S><S><A><C><A><S><S><R><G><Y><R> | Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.<BOP> | Q86Y37 |
Q9H7X7 | IFT22_HUMAN | Rab-like protein 5 | Homo | <M><L><K><A><K><I><L><F><V><G><P><C><E><S><G><K><T><V><L><A><N><F><L><T><E><S><S><D><I><T><E><Y><S><P><T><Q><G><V><R><I><L><E><F><E><N><P><H><V><T><S><N><N><K><G><T><G><C><E><F><E><L><W><D><C><G><G><D><A><K><F><E><S><C><W><P><A><L><M><K><D><A><H><G><V><V><I><V><F><N><A><D><I><P><S><H><R><K><E><M><E><M><W><Y><S><C><F><V><Q><Q><P><S><L><Q><D><T><Q><C><M><L><I><A><H><H><K><P><G><S><G><D><D><K><G><S><L><S><L><S><P><P><L><N><K><L><K><L><V><H><S><N><L><E><D><D><P><E><E><I><R><M><E><F><I><K><Y><L><K><S><I><I><N><S><M><S><E><S><R><D><R><E><E><M><S><I><M><T> | Small GTPase-like component of the intraflagellar transport (IFT) complex B.<BOP> | Q9H7X7 |
Q6AZZ1 | TRI68_HUMAN | Tripartite motif-containing protein 68 | Homo | <M><D><P><T><A><L><V><E><A><I><V><E><E><V><A><C><P><I><C><M><T><F><L><R><E><P><M><S><I><D><C><G><H><S><F><C><H><S><C><L><S><G><L><W><E><I><P><G><E><S><Q><N><W><G><Y><T><C><P><L><C><R><A><P><V><Q><P><R><N><L><R><P><N><W><Q><L><A><N><V><V><E><K><V><R><L><L><R><L><H><P><G><M><G><L><K><G><D><L><C><E><R><H><G><E><K><L><K><M><F><C><K><E><D><V><L><I><M><C><E><A><C><S><Q><S><P><E><H><E><A><H><S><V><V><P><M><E><D><V><A><W><E><Y><K><W><E><L><H><E><A><L><E><H><L><K><K><E><Q><E><E><A><W><K><L><E><V><G><E><R><K><R><T><A><T><W><K><I><Q><V><E><T><R><K><Q><S><I><V><W><E><F><E><K><Y><Q><R><L><L><E><K><K><Q><P><P><H><R><Q><L><G><A><E><V><A><A><A><L><A><S><L><Q><R><E><A><A><E><T><M><Q><K><L><E><L><N><H><S><E><L><I><Q><Q><S><Q><V><L><W><R><M><I><A><E><L><K><E><R><S><Q><R><P><V><R><W><M><L><Q><D><I><Q><E><V><L><N><R><S><K><S><W><S><L><Q><Q><P><E><P><I><S><L><E><L><K><T><D><C><R><V><L><G><L><R><E><I><L><K><T><Y><A><A><D><V><R><L><D><P><D><T><A><Y><S><R><L><I><V><S><E><D><R><K><R><V><H><Y><G><D><T><N><Q><K><L><P><D><N><P><E><R><F><Y><R><Y><N><I><V><L><G><S><Q><C><I><S><S><G><R><H><Y><W><E><V><E><V><G><D><R><S><E><W><G><L><G><V><C><K><Q><N><V><D><R><K><E><V><V><Y><L><S><P><H><Y><G><F><W><V><I><R><L><R><K><G><N><E><Y><R><A><G><T><D><E><Y><P><I><L><S><L><P><V><P><P><R><R><V><G><I><F><V><D><Y><E><A><H><D><I><S><F><Y><N><V><T><D><C><G><S><H><I><F><T><F><P><R><Y><P><F><P><G><R><L><L><P><Y><F><S><P><C><Y><S><I><G><T><N><N><T><A><P><L><A><I><C><S><L><D><G><E><D> | Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.<BOP> | Q6AZZ1 |
O14508 | SOCS2_HUMAN | STAT-induced STAT inhibitor 2 | Homo | <M><T><L><R><C><L><E><P><S><G><N><G><G><E><G><T><R><S><Q><W><G><T><A><G><S><A><E><E><P><S><P><Q><A><A><R><L><A><K><A><L><R><E><L><G><Q><T><G><W><Y><W><G><S><M><T><V><N><E><A><K><E><K><L><K><E><A><P><E><G><T><F><L><I><R><D><S><S><H><S><D><Y><L><L><T><I><S><V><K><T><S><A><G><P><T><N><L><R><I><E><Y><Q><D><G><K><F><R><L><D><S><I><I><C><V><K><S><K><L><K><Q><F><D><S><V><V><H><L><I><D><Y><Y><V><Q><M><C><K><D><K><R><T><G><P><E><A><P><R><N><G><T><V><H><L><Y><L><T><K><P><L><Y><T><S><A><P><S><L><Q><H><L><C><R><L><T><I><N><K><C><T><G><A><I><W><G><L><P><L><P><T><R><L><K><D><Y><L><E><E><Y><K><F><Q><V> | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.<BOP> | O14508 |
Q9H204 | MED28_HUMAN | Tumor angiogenesis marker EG-1 | Homo | <M><A><A><P><L><G><G><M><F><S><G><Q><P><P><G><P><P><Q><A><P><P><G><L><P><G><Q><A><S><L><L><Q><A><A><P><G><A><P><R><P><S><S><S><T><L><V><D><E><L><E><S><S><F><E><A><C><F><A><S><L><V><S><Q><D><Y><V><N><G><T><D><Q><E><E><I><R><T><G><V><D><Q><C><I><Q><K><F><L><D><I><A><R><Q><T><E><C><F><F><L><Q><K><R><L><Q><L><S><V><Q><K><P><E><Q><V><I><K><E><D><V><S><E><L><R><N><E><L><Q><R><K><D><A><L><V><Q><K><H><L><T><K><L><R><H><W><Q><Q><V><L><E><D><I><N><V><Q><H><K><K><P><A><D><I><P><Q><G><S><L><A><Y><L><E><Q><A><S><A><N><I><P><A><P><L><K><P><T> | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.<BOP> | Q9H204 |
A0A286YEV6 | SCGR4_HUMAN | Keratin-associated protein 28-4 | Homo | <M><G><C><C><G><C><G><S><C><G><G><C><G><G><R><C><G><G><G><C><G><G><G><C><S><G><G><C><G><G><G><C><G><G><G><C><G><G><G><C><G><S><C><T><T><C><R><C><Y><R><V><G><C><C><S><S><C><C><P><C><C><R><G><C><C><G><G><C><C><S><T><P><V><I><C><C><C><R><R><T><C><G><S><C><G><C><G><Y><G><K><G><C><C><Q><Q><K><C><C><C><Q><K><Q><C><C><C> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | A0A286YEV6 |
Q9NR90 | DAZ3_HUMAN | Deleted in azoospermia protein 3 | Homo | <M><S><A><A><N><P><E><T><P><N><S><T><I><S><R><E><A><S><T><Q><S><S><S><A><A><A><S><Q><G><W><V><L><P><E><G><K><I><V><P><N><T><V><F><V><G><G><I><D><A><R><M><D><E><T><E><I><G><S><C><F><G><R><Y><G><S><V><K><E><V><K><I><I><T><N><R><T><G><V><S><K><G><Y><G><F><V><S><F><V><N><D><V><D><V><Q><K><I><V><G><S><Q><I><H><F><H><G><K><K><L><K><L><G><P><A><I><R><K><Q><K><L><C><A><R><H><V><Q><P><R><P><L><V><V><N><P><P><P><P><P><Q><F><Q><N><V><W><R><N><P><N><T><E><T><Y><L><Q><P><Q><I><T><P><N><P><V><T><Q><H><V><Q><A><Y><S><A><Y><P><H><S><P><G><Q><V><I><T><G><C><Q><L><L><V><Y><N><Y><Q><E><Y><P><T><Y><P><D><S><A><F><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><P><F><P><A><Y><P><R><S><P><F><Q><V><T><A><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><P><F><Q><V><A><T><G><Y><Q><F><P><V><Y><N><Y><Q><P><F><P><A><Y><P><S><S><P><F><Q><V><T><A><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><P><F><Q><V><A><T><G><Y><Q><F><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><P><V><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><P><F><Q><V><A><T><G><Y><Q><F><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><P><V><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><P><F><Q><V><A><T><G><Y><Q><F><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><P><V><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><A><V><Q><V><T><T><G><Y><Q><F><H><V><Y><N><Y><Q><M><P><P><Q><C><P><V><G><E><Q><R><R><N><L><W><T><E><A><Y><K><W><W><Y><L><V><C><L><I><Q><R><R><D> | RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.<BOP> | Q9NR90 |
Q9UJT1 | TBD_HUMAN | Delta-tubulin | Homo | <M><S><I><V><T><V><Q><L><G><Q><C><G><N><Q><I><G><F><E><V><F><D><A><L><L><S><D><S><H><S><S><Q><G><L><C><S><M><R><E><N><E><A><Y><Q><A><S><C><K><E><R><F><F><S><E><E><E><N><G><V><P><I><A><R><A><V><L><V><D><M><E><P><K><V><I><N><Q><M><L><S><K><A><A><Q><S><G><Q><W><K><Y><G><Q><H><A><C><F><C><Q><K><Q><G><S><G><N><N><W><A><Y><G><Y><S><V><H><G><P><R><H><E><E><S><I><M><N><I><I><R><K><E><V><E><K><C><D><S><F><S><G><F><F><I><I><M><S><M><A><G><G><T><G><S><G><L><G><A><F><V><T><Q><N><L><E><D><Q><Y><S><N><S><L><K><M><N><Q><I><I><W><P><Y><G><T><G><E><V><I><V><Q><N><Y><N><S><I><L><T><L><S><H><L><Y><R><S><S><D><A><L><L><L><H><E><N><D><A><I><H><K><I><C><A><K><L><M><N><I><K><Q><I><S><F><S><D><I><N><Q><V><L><A><H><Q><L><G><S><V><F><Q><P><T><Y><S><A><E><S><S><F><H><Y><R><R><N><P><L><G><D><L><M><E><H><L><V><P><H><P><E><F><K><M><L><S><V><R><N><I><P><H><M><S><E><N><S><L><A><Y><T><T><F><T><W><A><G><L><L><K><H><L><R><Q><M><L><I><S><N><A><K><M><E><E><G><I><D><R><H><V><W><P><P><L><S><G><L><P><P><L><S><K><M><S><L><N><K><D><L><H><F><N><T><S><I><A><N><L><V><I><L><R><G><K><D><V><Q><S><A><D><V><E><G><F><K><D><P><A><L><Y><T><S><W><L><K><P><V><N><A><F><N><V><W><K><T><Q><R><A><F><S><K><Y><E><K><S><A><V><L><V><S><N><S><Q><F><L><V><K><P><L><D><M><I><V><G><K><A><W><N><M><F><A><S><K><A><Y><I><H><Q><Y><T><K><F><G><I><E><E><E><D><F><L><D><S><F><T><S><L><E><Q><V><V><A><S><Y><C><N><L> | Acts as a positive regulator of hedgehog signaling and regulates ciliary function.<BOP> | Q9UJT1 |
Q5VSY0 | GKAP1_HUMAN | cGMP-dependent protein kinase-anchoring protein of 42 kDa | Homo | <M><A><S><A><V><L><S><S><V><P><T><T><A><S><R><F><A><L><L><Q><V><D><S><G><S><G><S><D><S><E><P><G><K><G><K><G><R><N><T><G><K><S><Q><T><L><G><S><K><S><T><T><N><E><K><K><R><E><K><R><R><K><K><K><E><Q><Q><Q><S><E><A><N><E><L><R><N><L><A><F><K><K><I><P><Q><K><S><S><H><A><V><C><N><A><Q><H><D><L><P><L><S><N><P><V><Q><K><D><S><R><E><E><N><W><Q><E><W><R><Q><R><D><E><Q><L><T><S><E><M><F><E><A><D><L><E><K><A><L><L><L><S><K><L><E><Y><E><E><H><K><K><E><Y><E><D><A><E><N><T><S><T><Q><S><K><V><M><N><K><K><D><K><R><K><N><H><Q><G><K><D><R><P><L><T><V><S><L><K><D><F><H><S><E><D><H><I><S><K><K><T><E><E><L><S><S><S><Q><T><L><S><H><D><G><G><F><F><N><R><L><E><D><D><V><H><K><I><L><I><R><E><K><R><R><E><Q><L><T><E><Y><N><G><T><D><N><C><T><A><H><E><H><N><Q><E><V><V><L><K><D><G><R><I><E><R><L><K><L><E><L><E><R><K><D><A><E><I><Q><K><L><K><N><V><I><T><Q><W><E><A><K><Y><K><E><V><K><A><R><N><A><Q><L><L><K><M><L><Q><E><G><E><M><K><D><K><A><E><I><L><L><Q><V><D><E><S><Q><S><I><K><N><E><L><T><I><Q><V><T><S><L><H><A><A><L><E><Q><E><R><S><K><V><K><V><L><Q><A><E><L><A><K><Y><Q><G><G><R><K><G><K><R><N><S><E><S><D><Q><C><R> | Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation.<BOP> | Q5VSY0 |
Q2M5E4 | RGS21_HUMAN | Regulator of G-protein signaling 21 | Homo | <M><P><V><K><C><C><F><Y><R><S><P><T><A><E><T><M><T><W><S><E><N><M><D><T><L><L><A><N><Q><A><G><L><D><A><F><R><I><F><L><K><S><E><F><S><E><E><N><V><E><F><W><L><A><C><E><D><F><K><K><T><K><N><A><D><K><I><A><S><K><A><K><M><I><Y><S><E><F><I><E><A><D><A><P><K><E><I><N><I><D><F><G><T><R><D><L><I><S><K><N><I><A><E><P><T><L><K><C><F><D><E><A><Q><K><L><I><Y><C><L><M><A><K><D><S><F><P><R><F><L><K><S><E><I><Y><K><K><L><V><N><S><Q><Q><V><P><N><H><K><K><W><L><P><F><L> | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.<BOP> | Q2M5E4 |
P18505 | GBRB1_HUMAN | GABA(A) receptor subunit beta-1 | Homo | <M><W><T><V><Q><N><R><E><S><L><G><L><L><S><F><P><V><M><I><T><M><V><C><C><A><H><S><T><N><E><P><S><N><M><S><Y><V><K><E><T><V><D><R><L><L><K><G><Y><D><I><R><L><R><P><D><F><G><G><P><P><V><D><V><G><M><R><I><D><V><A><S><I><D><M><V><S><E><V><N><M><D><Y><T><L><T><M><Y><F><Q><Q><S><W><K><D><K><R><L><S><Y><S><G><I><P><L><N><L><T><L><D><N><R><V><A><D><Q><L><W><V><P><D><T><Y><F><L><N><D><K><K><S><F><V><H><G><V><T><V><K><N><R><M><I><R><L><H><P><D><G><T><V><L><Y><G><L><R><I><T><T><T><A><A><C><M><M><D><L><R><R><Y><P><L><D><E><Q><N><C><T><L><E><I><E><S><Y><G><Y><T><T><D><D><I><E><F><Y><W><N><G><G><E><G><A><V><T><G><V><N><K><I><E><L><P><Q><F><S><I><V><D><Y><K><M><V><S><K><K><V><E><F><T><T><G><A><Y><P><R><L><S><L><S><F><R><L><K><R><N><I><G><Y><F><I><L><Q><T><Y><M><P><S><T><L><I><T><I><L><S><W><V><S><F><W><I><N><Y><D><A><S><A><A><R><V><A><L><G><I><T><T><V><L><T><M><T><T><I><S><T><H><L><R><E><T><L><P><K><I><P><Y><V><K><A><I><D><I><Y><L><M><G><C><F><V><F><V><F><L><A><L><L><E><Y><A><F><V><N><Y><I><F><F><G><K><G><P><Q><K><K><G><A><S><K><Q><D><Q><S><A><N><E><K><N><K><L><E><M><N><K><V><Q><V><D><A><H><G><N><I><L><L><S><T><L><E><I><R><N><E><T><S><G><S><E><V><L><T><S><V><S><D><P><K><A><T><M><Y><S><Y><D><S><A><S><I><Q><Y><R><K><P><L><S><S><R><E><A><Y><G><R><A><L><D><R><H><G><V><P><S><K><G><R><I><R><R><R><A><S><Q><L><K><V><K><I><P><D><L><T><D><V><N><S><I><D><K><W><S><R><M><F><F><P><I><T><F><S><L><F><N><V><V><Y><W><L><Y><Y><V><H> | Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.<BOP> | P18505 |
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