accession
stringlengths 6
10
| name
stringlengths 8
11
| Full Name
stringlengths 2
102
⌀ | taxon
stringclasses 1
value | sequence
stringlengths 48
2.3k
| function
stringlengths 15
1.34k
| AlphaFoldDB
stringlengths 6
10
|
|---|---|---|---|---|---|---|
Q9H9V9
|
JMJD4_HUMAN
|
Lysyl-hydroxylase JMJD4
|
Homo
|
<M><R><A><G><P><E><P><Q><A><L><A><G><Q><K><R><G><A><L><R><L><L><V><P><R><L><V><L><T><V><S><A><P><A><E><V><R><R><R><V><L><R><P><V><L><S><W><M><D><R><E><T><R><A><L><A><D><S><H><F><R><G><L><G><V><D><V><P><G><V><G><Q><A><P><G><R><V><A><F><V><S><E><P><G><A><F><S><Y><A><D><F><V><R><G><F><L><L><P><N><L><P><C><V><F><S><S><A><F><T><Q><G><W><G><S><R><R><R><W><V><T><P><A><G><R><P><D><F><D><H><L><L><R><T><Y><G><D><V><V><V><P><V><A><N><C><G><V><Q><E><Y><N><S><N><P><K><E><H><M><T><L><R><D><Y><I><T><Y><W><K><E><Y><I><Q><A><G><Y><S><S><P><R><G><C><L><Y><L><K><D><W><H><L><C><R><D><F><P><V><E><D><V><F><T><L><P><V><Y><F><S><S><D><W><L><N><E><F><W><D><A><L><D><V><D><D><Y><R><F><V><Y><A><G><P><A><G><S><W><S><P><F><H><A><D><I><F><R><S><F><S><W><S><V><N><V><C><G><R><K><K><W><L><L><F><P><P><G><Q><E><E><A><L><R><D><R><H><G><N><L><P><Y><D><V><T><S><P><A><L><C><D><T><H><L><H><P><R><N><Q><L><A><G><P><P><L><E><I><T><Q><E><A><G><E><M><V><F><V><P><S><G><W><H><H><Q><V><H><N><L><D><D><T><I><S><I><N><H><N><W><V><N><G><F><N><L><A><N><M><W><R><F><L><Q><Q><E><L><C><A><V><Q><E><E><V><S><E><W><R><D><S><M><P><D><W><H><H><H><C><Q><V><I><M><R><S><C><S><G><I><N><F><E><E><F><Y><H><F><L><K><V><I><A><E><K><R><L><L><V><L><R><E><A><A><A><E><D><G><A><G><L><G><F><E><Q><A><A><F><D><V><G><R><I><T><E><V><L><A><S><L><V><A><H><P><D><F><Q><R><V><D><T><S><A><F><S><P><Q><P><K><E><L><L><Q><Q><L><R><E><A><V><D><A><A><A><A><P>
|
Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1.<BOP>
|
Q9H9V9
|
O95751
|
LDOC1_HUMAN
|
Leucine zipper protein down-regulated in cancer cells
|
Homo
|
<M><V><D><E><L><V><L><L><L><H><A><L><L><M><R><H><R><A><L><S><I><E><N><S><Q><L><M><E><Q><L><R><L><L><V><C><E><R><A><S><L><L><R><Q><V><R><P><P><S><C><P><V><P><F><P><E><T><F><N><G><E><S><S><R><L><P><E><F><I><V><Q><T><A><S><Y><M><L><V><N><E><N><R><F><C><N><D><A><M><K><V><A><F><L><I><S><L><L><T><G><E><A><E><E><W><V><V><P><Y><I><E><M><D><S><P><I><L><G><D><Y><R><A><F><L><D><E><M><K><Q><C><F><G><W><D><D><D><E><D><D><D><D><E><E><E><E><D><D><Y>
|
May have an important role in the development and/or progression of some cancers.<BOP>
|
O95751
|
Q96C11
|
FGGY_HUMAN
|
D-ribulokinase FGGY
|
Homo
|
<M><S><G><G><E><Q><K><P><E><R><Y><Y><V><G><V><D><V><G><T><G><S><V><R><A><A><L><V><D><Q><S><G><V><L><L><A><F><A><D><Q><P><I><K><N><W><E><P><Q><F><N><H><H><E><Q><S><S><E><D><I><W><A><A><C><C><V><V><T><K><K><V><V><Q><G><I><D><L><N><Q><I><R><G><L><G><F><D><A><T><C><S><L><V><V><L><D><K><Q><F><H><P><L><P><V><N><Q><E><G><D><S><H><R><N><V><I><M><W><L><D><H><R><A><V><S><Q><V><N><R><I><N><E><T><K><H><S><V><L><Q><Y><V><G><G><V><M><S><V><E><M><Q><A><P><K><L><L><W><L><K><E><N><L><R><E><I><C><W><D><K><A><G><H><F><F><D><L><P><D><F><L><S><W><K><A><T><G><V><T><A><R><S><L><C><S><L><V><C><K><W><T><Y><S><A><E><K><G><W><D><D><S><F><W><K><M><I><G><L><E><D><F><V><A><D><N><Y><S><K><I><G><N><Q><V><L><P><P><G><A><S><L><G><N><G><L><T><P><E><A><A><R><D><L><G><L><L><P><G><I><A><V><A><A><S><L><I><D><A><H><A><G><G><L><G><V><I><G><A><D><V><R><G><H><G><L><I><C><E><G><Q><P><V><T><S><R><L><A><V><I><C><G><T><S><S><C><H><M><G><I><S><K><D><P><I><F><V><P><G><V><W><G><P><Y><F><S><A><M><V><P><G><F><W><L><N><E><G><G><Q><S><V><T><G><K><L><I><D><H><M><V><Q><G><H><A><A><F><P><E><L><Q><V><K><A><T><A><R><C><Q><S><I><Y><A><Y><L><N><S><H><L><D><L><I><K><K><A><Q><P><V><G><F><L><T><V><D><L><H><V><W><P><D><F><H><G><N><R><S><P><L><A><D><L><T><L><K><G><M><V><T><G><L><K><L><S><Q><D><L><D><D><L><A><I><L><Y><L><A><T><V><Q><A><I><A><L><G><T><R><F><I><I><E><A><M><E><A><A><G><H><S><I><S><T><L><F><L><C><G><G><L><S><K><N><P><L><F><V><Q><M><H><A><D><I><T><G><M><P><V><V><L><S><Q><E><V><E><S><V><L><V><G><A><A><V><L><G><A><C><A><S><G><D><F><A><S><V><Q><E><A><M><A><K><M><S><K><V><G><K><V><V><F><P><R><L><Q><D><K><K><Y><Y><D><K><K><Y><Q><V><F><L><K><L><V><E><H><Q><K><E><Y><L><A><I><M><N><D><D>
|
Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to form D-ribulose 5-phosphate. Postulated to function in a metabolite repair mechanism by preventing toxic accumulation of free D-ribulose formed by non-specific phosphatase activities. Alternatively, may play a role in regulating D-ribulose 5-phosphate recycling in the pentose phosphate pathway. Can phosphorylate ribitol with low efficiency.<BOP>
|
Q96C11
|
Q9H6S1
|
AZI2_HUMAN
|
TILP
|
Homo
|
<M><D><A><L><V><E><D><D><I><C><I><L><N><H><E><K><A><H><K><R><D><T><V><T><P><V><S><I><Y><S><G><D><E><S><V><A><S><H><F><A><L><V><T><A><Y><E><D><I><K><K><R><L><K><D><S><E><K><E><N><S><L><L><K><K><R><I><R><F><L><E><E><K><L><I><A><R><F><E><E><E><T><S><S><V><G><R><E><Q><V><N><K><A><Y><H><A><Y><R><E><V><C><I><D><R><D><N><L><K><S><K><L><D><K><M><N><K><D><N><S><E><S><L><K><V><L><N><E><Q><L><Q><S><K><E><V><E><L><L><Q><L><R><T><E><V><E><T><Q><Q><V><M><R><N><L><N><P><P><S><S><N><W><E><V><E><K><L><S><C><D><L><K><I><H><G><L><E><Q><E><L><E><L><M><R><K><E><C><S><D><L><K><I><E><L><Q><K><A><K><Q><T><D><P><Y><Q><E><D><N><L><K><S><R><D><L><Q><K><L><S><I><S><S><D><N><M><Q><H><A><Y><W><E><L><K><R><E><M><S><N><L><H><L><V><T><Q><V><Q><A><E><L><L><R><K><L><K><T><S><T><A><I><K><K><A><C><A><P><V><G><C><S><E><D><L><G><R><D><S><T><K><L><H><L><M><N><F><T><A><T><Y><T><R><H><P><P><L><L><P><N><G><K><A><L><C><H><T><T><S><S><P><L><P><G><D><V><K><V><L><S><E><K><A><I><L><Q><S><W><T><D><N><E><R><S><I><P><N><D><G><T><C><F><Q><E><H><S><S><Y><G><R><N><S><L><E><D><N><S><W><V><F><P><S><P><P><K><S><S><E><T><A><F><G><E><T><K><T><K><T><L><P><L><P><N><L><P><P><L><H><Y><L><D><Q><H><N><Q><N><C><L><Y><K><N>
|
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity . Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization . Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 . Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B . Participates in IFNB promoter activation via TICAM1 .<BOP>
|
Q9H6S1
|
Q96I25
|
SPF45_HUMAN
|
RNA-binding motif protein 17
|
Homo
|
<M><S><L><Y><D><D><L><G><V><E><T><S><D><S><K><T><E><G><W><S><K><N><F><K><L><L><Q><S><Q><L><Q><V><K><K><A><A><L><T><Q><A><K><S><Q><R><T><K><Q><S><T><V><L><A><P><V><I><D><L><K><R><G><G><S><S><D><D><R><Q><I><V><D><T><P><P><H><V><A><A><G><L><K><D><P><V><P><S><G><F><S><A><G><E><V><L><I><P><L><A><D><E><Y><D><P><M><F><P><N><D><Y><E><K><V><V><K><R><Q><R><E><E><R><Q><R><Q><R><E><L><E><R><Q><K><E><I><E><E><R><E><K><R><R><K><D><R><H><E><A><S><G><F><A><R><R><P><D><P><D><S><D><E><D><E><D><Y><E><R><E><R><R><K><R><S><M><G><G><A><A><I><A><P><P><T><S><L><V><E><K><D><K><E><L><P><R><D><F><P><Y><E><E><D><S><R><P><R><S><Q><S><S><K><A><A><I><P><P><P><V><Y><E><E><Q><D><R><P><R><S><P><T><G><P><S><N><S><F><L><A><N><M><G><G><T><V><A><H><K><I><M><Q><K><Y><G><F><R><E><G><Q><G><L><G><K><H><E><Q><G><L><S><T><A><L><S><V><E><K><T><S><K><R><G><G><K><I><I><V><G><D><A><T><E><K><D><A><S><K><K><S><D><S><N><P><L><T><E><I><L><K><C><P><T><K><V><V><L><L><R><N><M><V><G><A><G><E><V><D><E><D><L><E><V><E><T><K><E><E><C><E><K><Y><G><K><V><G><K><C><V><I><F><E><I><P><G><A><P><D><D><E><A><V><R><I><F><L><E><F><E><R><V><E><S><A><I><K><A><V><V><D><L><N><G><R><Y><F><G><G><R><V><V><K><A><C><F><Y><N><L><D><K><F><R><V><L><D><L><A><E><Q><V>
|
Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.<BOP>
|
Q96I25
|
O14879
|
IFIT3_HUMAN
|
Retinoic acid-induced gene G protein
|
Homo
|
<M><S><E><V><T><K><N><S><L><E><K><I><L><P><Q><L><K><C><H><F><T><W><N><L><F><K><E><D><S><V><S><R><D><L><E><D><R><V><C><N><Q><I><E><F><L><N><T><E><F><K><A><T><M><Y><N><L><L><A><Y><I><K><H><L><D><G><N><N><E><A><A><L><E><C><L><R><Q><A><E><E><L><I><Q><Q><E><H><A><D><Q><A><E><I><R><S><L><V><T><W><G><N><Y><A><W><V><Y><Y><H><L><G><R><L><S><D><A><Q><I><Y><V><D><K><V><K><Q><T><C><K><K><F><S><N><P><Y><S><I><E><Y><S><E><L><D><C><E><E><G><W><T><Q><L><K><C><G><R><N><E><R><A><K><V><C><F><E><K><A><L><E><E><K><P><N><N><P><E><F><S><S><G><L><A><I><A><M><Y><H><L><D><N><H><P><E><K><Q><F><S><T><D><V><L><K><Q><A><I><E><L><S><P><D><N><Q><Y><V><K><V><L><L><G><L><K><L><Q><K><M><N><K><E><A><E><G><E><Q><F><V><E><E><A><L><E><K><S><P><C><Q><T><D><V><L><R><S><A><A><K><F><Y><R><R><K><G><D><L><D><K><A><I><E><L><F><Q><R><V><L><E><S><T><P><N><N><G><Y><L><Y><H><Q><I><G><C><C><Y><K><A><K><V><R><Q><M><Q><N><T><G><E><S><E><A><S><G><N><K><E><M><I><E><A><L><K><Q><Y><A><M><D><Y><S><N><K><A><L><E><K><G><L><N><P><L><N><A><Y><S><D><L><A><E><F><L><E><T><E><C><Y><Q><T><P><F><N><K><E><V><P><D><A><E><K><Q><Q><S><H><Q><R><Y><C><N><L><Q><K><Y><N><G><K><S><E><D><T><A><V><Q><H><G><L><E><G><L><S><I><S><K><K><S><T><D><K><E><E><I><K><D><Q><P><Q><N><V><S><E><N><L><L><P><Q><N><A><P><N><Y><W><Y><L><Q><G><L><I><H><K><Q><N><G><D><L><L><Q><A><A><K><C><Y><E><K><E><L><G><R><L><L><R><D><A><P><S><G><I><G><S><I><F><L><S><A><S><E><L><E><D><G><S><E><E><M><G><Q><G><A><V><S><S><S><P><R><E><L><L><S><N><S><E><Q><L><N>
|
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.<BOP>
|
O14879
|
Q2TAK8
|
PWP3A_HUMAN
|
Protein expandere
|
Homo
|
<M><A><D><A><K><Y><V><L><C><R><W><E><K><R><L><W><P><A><K><V><L><A><R><T><A><T><S><T><K><N><K><R><R><K><E><Y><F><L><A><V><Q><I><L><S><L><E><E><K><I><K><V><K><S><T><E><V><E><I><L><E><K><S><Q><I><E><A><I><A><S><S><L><A><S><Q><N><E><V><P><A><A><P><L><E><E><L><A><Y><R><R><S><L><R><V><A><L><D><V><L><S><E><G><S><I><W><S><Q><E><S><S><A><G><T><G><R><A><D><R><S><L><R><G><K><P><M><E><H><V><S><S><P><C><D><S><N><S><S><S><L><P><R><G><D><V><L><G><S><S><R><P><H><R><R><R><P><C><V><Q><Q><S><L><S><S><S><F><T><C><E><K><D><P><E><C><K><V><D><H><K><K><G><L><R><K><S><E><N><P><R><G><P><L><V><L><P><A><G><G><G><A><Q><D><E><S><G><S><R><I><H><H><K><N><W><T><L><A><S><K><R><G><G><N><S><A><Q><K><A><S><L><C><L><N><G><S><S><L><S><E><D><D><T><E><R><D><M><G><S><K><G><G><S><W><A><A><P><S><L><P><S><G><V><R><E><D><D><P><C><A><N><A><E><G><H><D><P><G><L><P><L><G><S><L><T><A><P><P><A><P><E><P><S><A><C><S><E><P><G><E><C><P><A><K><K><R><P><R><L><D><G><S><Q><R><P><P><A><V><Q><L><E><P><M><A><A><G><A><A><P><S><P><G><P><G><P><G><P><R><E><S><V><T><P><R><S><T><A><R><L><G><P><P><P><S><H><A><S><A><D><A><T><R><C><L><P><C><P><D><S><Q><K><L><E><K><E><C><Q><S><S><E><E><S><M><G><S><N><S><M><R><S><I><L><E><E><D><E><E><D><E><E><P><P><R><V><L><L><Y><H><E><P><R><S><F><E><V><G><M><L><V><W><H><K><H><K><K><Y><P><F><W><P><A><V><V><K><S><V><R><Q><R><D><K><K><A><S><V><L><Y><I><E><G><H><M><N><P><K><M><K><G><F><T><V><S><L><K><S><L><K><H><F><D><C><K><E><K><Q><T><L><L><N><Q><A><R><E><D><F><N><Q><D><I><G><W><C><V><S><L><I><T><D><Y><R><V><R><L><G><C><G><S><F><A><G><S><F><L><E><Y><Y><A><A><D><I><S><Y><P><V><R><K><S><I><Q><Q><D><V><L><G><T><K><L><P><Q><L><S><K><G><S><P><E><E><P><V><V><G><C><P><L><G><Q><R><Q><P><C><R><K><M><L><P><D><R><S><R><A><A><R><D><R><A><N><Q><K><L><V><E><Y><I><V><K><A><K><G><A><E><S><H><L><R><A><I><L><K><S><R><K><P><S><R><W><L><Q><T><F><L><S><S><S><Q><Y><V><T><C><V><E><T><Y><L><E><D><E><G><Q><L><D><L><V><V><K><Y><L><Q><G><V><Y><Q><E><V><G><A><K><V><L><Q><R><T><N><G><D><R><I><R><F><I><L><D><V><L><L><P><E><A><I><I><C><A><I><S><A><V><D><E><V><D><Y><K><T><A><E><E><K><Y><I><K><G><P><S><L><S><Y><R><E><K><E><I><F><D><N><Q><L><L><E><E><R><N><R><R><R><R>
|
Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.<BOP>
|
Q2TAK8
|
O14832
|
PAHX_HUMAN
|
Phytanoyl-CoA alpha-hydroxylase
|
Homo
|
<M><E><Q><L><R><A><A><A><R><L><Q><I><V><L><G><H><L><G><R><P><S><A><G><A><V><V><A><H><P><T><S><G><T><I><S><S><A><S><F><H><P><Q><Q><F><Q><Y><T><L><D><N><N><V><L><T><L><E><Q><R><K><F><Y><E><E><N><G><F><L><V><I><K><N><L><V><P><D><A><D><I><Q><R><F><R><N><E><F><E><K><I><C><R><K><E><V><K><P><L><G><L><T><V><M><R><D><V><T><I><S><K><S><E><Y><A><P><S><E><K><M><I><T><K><V><Q><D><F><Q><E><D><K><E><L><F><R><Y><C><T><L><P><E><I><L><K><Y><V><E><C><F><T><G><P><N><I><M><A><M><H><T><M><L><I><N><K><P><P><D><S><G><K><K><T><S><R><H><P><L><H><Q><D><L><H><Y><F><P><F><R><P><S><D><L><I><V><C><A><W><T><A><M><E><H><I><S><R><N><N><G><C><L><V><V><L><P><G><T><H><K><G><S><L><K><P><H><D><Y><P><K><W><E><G><G><V><N><K><M><F><H><G><I><Q><D><Y><E><E><N><K><A><R><V><H><L><V><M><E><K><G><D><T><V><F><F><H><P><L><L><I><H><G><S><G><Q><N><K><T><Q><G><F><R><K><A><I><S><C><H><F><A><S><A><D><C><H><Y><I><D><V><K><G><T><S><Q><E><N><I><E><K><E><V><V><G><I><A><H><K><F><F><G><A><E><N><S><V><N><L><K><D><I><W><M><F><R><A><R><L><V><K><G><E><R><T><N><L>
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Catalyzes the 2-hydroxylation of not only racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA, but also a variety of other mono-branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms) . Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl- and 4-methyl-branched acyl-CoAs .<BOP>
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O14832
|
Q96AA3
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RFT1_HUMAN
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Protein RFT1 homolog
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Homo
|
<M><G><S><Q><E><V><L><G><H><A><A><R><L><A><S><S><G><L><L><L><Q><V><L><F><R><L><I><T><F><V><L><N><A><F><I><L><R><F><L><S><K><E><I><V><G><V><V><N><V><R><L><T><L><L><Y><S><T><T><L><F><L><A><R><E><A><F><R><R><A><C><L><S><G><G><T><Q><R><D><W><S><Q><T><L><N><L><L><W><L><T><V><P><L><G><V><F><W><S><L><F><L><G><W><I><W><L><Q><L><L><E><V><P><D><P><N><V><V><P><H><Y><A><T><G><V><V><L><F><G><L><S><A><V><V><E><L><L><G><E><P><F><W><V><L><A><Q><A><H><M><F><V><K><L><K><V><I><A><E><S><L><S><V><I><L><K><S><V><L><T><A><F><L><V><L><W><L><P><H><W><G><L><Y><I><F><S><L><A><Q><L><F><Y><T><T><V><L><V><L><C><Y><V><I><Y><F><T><K><L><L><G><S><P><E><S><T><K><L><Q><T><L><P><V><S><R><I><T><D><L><L><P><N><I><T><R><N><G><A><F><I><N><W><K><E><A><K><L><T><W><S><F><F><K><Q><S><F><L><K><Q><I><L><T><E><G><E><R><Y><V><M><T><F><L><N><V><L><N><F><G><D><Q><G><V><Y><D><I><V><N><N><L><G><S><L><V><A><R><L><I><F><Q><P><I><E><E><S><F><Y><I><F><F><A><K><V><L><E><R><G><K><D><A><T><L><Q><K><Q><E><D><V><A><V><A><A><A><V><L><E><S><L><L><K><L><A><L><L><A><G><L><T><I><T><V><F><G><F><A><Y><S><Q><L><A><L><D><I><Y><G><G><T><M><L><S><S><G><S><G><P><V><L><L><R><S><Y><C><L><Y><V><L><L><L><A><I><N><G><V><T><E><C><F><T><F><A><A><M><S><K><E><E><V><D><R><Y><N><F><V><M><L><A><L><S><S><S><F><L><V><L><S><Y><L><L><T><R><W><C><G><S><V><G><F><I><L><A><N><C><F><N><M><G><I><R><I><T><Q><S><L><C><F><I><H><R><Y><Y><R><R><S><P><H><R><P><L><A><G><L><H><L><S><P><V><L><L><G><T><F><A><L><S><G><G><V><T><A><V><S><E><V><F><L><C><C><E><Q><G><W><P><A><R><L><A><H><I><A><V><G><A><F><C><L><G><A><T><L><G><T><A><F><L><T><E><T><K><L><I><H><F><L><R><T><Q><L><G><V><P><R><R><T><D><K><M><T>
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May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.<BOP>
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Q96AA3
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Q96N77
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ZN641_HUMAN
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Zinc finger protein 641
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Homo
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<M><Q><A><E><D><R><S><Q><F><G><S><A><A><E><M><L><S><E><Q><T><A><A><L><G><T><G><W><E><S><M><N><V><Q><L><D><G><A><E><P><Q><V><E><R><G><S><Q><E><E><R><P><W><R><T><V><P><G><P><L><E><H><L><C><C><D><L><E><E><E><P><Q><S><L><Q><E><K><A><Q><S><A><P><W><V><P><A><I><P><Q><E><G><N><T><G><D><W><E><M><A><A><A><L><L><A><A><G><S><Q><G><L><V><T><I><K><D><V><S><L><C><F><S><Q><E><E><W><R><S><L><D><P><S><Q><T><D><F><Y><G><E><Y><V><M><Q><E><N><C><G><I><V><V><S><L><R><F><P><I><P><K><L><D><M><L><S><Q><L><E><G><G><E><E><Q><W><V><P><D><P><Q><D><L><E><E><R><D><I><L><R><V><T><Y><T><G><D><G><S><E><H><E><G><D><T><P><E><L><E><A><E><P><P><R><M><L><S><S><V><S><E><D><T><V><L><W><N><P><E><H><D><E><S><W><D><S><M><P><S><S><S><R><G><M><L><L><G><P><P><F><L><Q><E><D><S><F><S><N><L><L><C><S><T><E><M><D><S><L><L><R><P><H><T><C><P><Q><C><G><K><Q><F><V><W><G><S><H><L><A><R><H><Q><Q><T><H><T><G><E><R><P><Y><S><C><L><K><C><E><K><T><F><G><R><R><H><H><L><I><R><H><Q><K><T><H><L><H><D><K><T><S><R><C><S><E><C><G><K><N><F><R><C><N><S><H><L><A><S><H><Q><R><V><H><A><E><G><K><S><C><K><G><Q><E><V><G><E><S><P><G><T><R><K><R><Q><R><A><P><P><V><P><K><C><H><V><C><T><E><C><G><K><S><F><G><R><R><H><H><L><V><R><H><W><L><T><H><T><G><E><K><P><F><Q><C><P><R><C><E><K><S><F><G><R><K><H><H><L><D><R><H><L><L><T><H><Q><G><Q><S><P><R><N><S><W><D><R><G><T><S><V><F>
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Transcriptional activator. Activates transcriptional activities of SRE and AP-1.<BOP>
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Q96N77
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Q8TF45
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ZN418_HUMAN
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Zinc finger protein 418
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Homo
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<M><Q><G><T><V><A><F><E><D><V><A><V><N><F><S><Q><E><E><W><S><L><L><S><E><V><Q><R><C><L><Y><H><D><V><M><L><E><N><W><V><L><I><S><S><L><G><C><W><C><G><S><E><D><E><E><A><P><S><K><K><S><I><S><I><Q><R><V><S><Q><V><S><T><P><G><A><G><V><S><P><K><K><A><H><S><C><E><M><C><G><A><I><L><G><D><I><L><H><L><A><D><H><Q><G><T><H><H><K><Q><K><L><H><R><C><E><A><W><G><N><K><L><Y><D><S><S><N><R><P><H><Q><N><Q><Y><L><G><E><K><P><Y><R><S><S><V><E><E><A><L><F><V><K><R><C><K><F><H><V><S><E><E><S><S><I><F><I><Q><S><G><K><D><F><L><P><S><S><G><L><L><L><Q><E><A><T><H><T><G><E><K><S><N><S><K><P><E><C><E><S><P><F><Q><W><G><D><T><H><Y><S><C><G><E><C><M><K><H><S><S><T><K><H><V><F><V><Q><Q><Q><R><L><P><S><R><E><E><C><Y><C><W><E><C><G><K><S><F><S><K><Y><D><S><V><S><N><H><Q><R><V><H><T><G><K><R><P><Y><E><C><G><E><C><G><K><S><F><S><H><K><G><S><L><V><Q><H><Q><R><V><H><T><G><K><R><P><Y><E><C><G><E><C><G><K><S><F><S><H><K><G><S><L><V><Q><H><Q><R><V><H><T><G><E><R><P><Y><E><C><G><E><C><G><K><S><F><S><Q><N><G><T><L><I><K><H><Q><R><V><H><T><G><E><R><P><Y><E><C><E><E><C><G><K><C><F><T><Q><K><G><N><L><I><Q><H><Q><R><G><H><T><S><E><R><P><Y><E><C><E><E><C><G><K><C><F><S><Q><K><G><T><L><T><E><H><H><R><V><H><T><R><E><R><P><Y><E><C><G><E><C><G><K><S><F><S><R><K><G><H><L><R><N><H><Q><R><G><H><T><G><E><R><P><Y><E><C><G><E><C><G><K><S><F><S><R><K><G><N><L><I><Q><H><Q><R><S><H><T><G><E><R><P><Y><E><C><R><E><C><R><K><L><F><R><G><K><S><H><L><I><E><H><Q><R><V><H><T><G><E><R><P><Y><E><C><N><E><C><G><K><S><F><Q><D><S><S><G><F><R><V><H><Q><R><V><H><T><G><E><K><P><F><E><C><S><E><C><G><K><S><F><P><Q><S><C><S><L><L><R><H><R><R><V><H><T><G><E><R><P><Y><E><C><G><E><C><G><K><S><F><H><Q><S><S><S><L><L><R><H><Q><K><T><H><T><A><E><R><P><Y><E><C><R><E><C><G><K><F><F><S><S><L><L><E><H><R><R><V><H><T><G><E><R><P><Y><E><C><R><E><C><G><K><T><F><T><R><R><S><A><H><F><K><H><Q><R><L><H><T><R><G><K><P><Y><E><C><S><E><C><G><K><S><F><A><E><T><F><S><L><T><E><H><R><R><V><H><T><G><E><R><P><Y><E><C><S><E><C><G><K><S><F><H><R><S><S><S><L><L><R><H><Q><R><V><H><T><E><R><S><P><Y><K>
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Transcriptional repressor.<BOP>
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Q8TF45
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Q6FI13
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H2A2A_HUMAN
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Histone H2A/o
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Homo
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<M><S><G><R><G><K><Q><G><G><K><A><R><A><K><A><K><S><R><S><S><R><A><G><L><Q><F><P><V><G><R><V><H><R><L><L><R><K><G><N><Y><A><E><R><V><G><A><G><A><P><V><Y><M><A><A><V><L><E><Y><L><T><A><E><I><L><E><L><A><G><N><A><A><R><D><N><K><K><T><R><I><I><P><R><H><L><Q><L><A><I><R><N><D><E><E><L><N><K><L><L><G><K><V><T><I><A><Q><G><G><V><L><P><N><I><Q><A><V><L><L><P><K><K><T><E><S><H><H><K><A><K><G><K>
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Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<BOP>
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Q6FI13
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P01225
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FSHB_HUMAN
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Follitropin beta chain
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Homo
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<M><K><T><L><Q><F><F><F><L><F><C><C><W><K><A><I><C><C><N><S><C><E><L><T><N><I><T><I><A><I><E><K><E><E><C><R><F><C><I><S><I><N><T><T><W><C><A><G><Y><C><Y><T><R><D><L><V><Y><K><D><P><A><R><P><K><I><Q><K><T><C><T><F><K><E><L><V><Y><E><T><V><R><V><P><G><C><A><H><H><A><D><S><L><Y><T><Y><P><V><A><T><Q><C><H><C><G><K><C><D><S><D><S><T><D><C><T><V><R><G><L><G><P><S><Y><C><S><F><G><E><M><K><E>
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Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways . Follitropin is involved in follicle development and spermatogenesis in reproductive organs .<BOP>
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P01225
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P41214
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EIF2D_HUMAN
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Ligatin
|
Homo
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<M><F><A><K><A><F><R><V><K><S><N><T><A><I><K><G><S><D><R><R><K><L><R><A><D><V><T><T><A><F><P><T><L><G><T><D><Q><V><S><E><L><V><P><G><K><E><E><L><N><I><V><K><L><Y><A><H><K><G><D><A><V><T><V><Y><V><S><G><G><N><P><I><L><F><E><L><E><K><N><L><Y><P><T><V><Y><T><L><W><S><Y><P><D><L><L><P><T><F><T><T><W><P><L><V><L><E><K><L><V><G><G><A><D><L><M><L><P><G><L><V><M><P><P><A><G><L><P><Q><V><Q><K><G><D><L><C><A><I><S><L><V><G><N><R><A><P><V><A><I><G><V><A><A><M><S><T><A><E><M><L><T><S><G><L><K><G><R><G><F><S><V><L><H><T><Y><Q><D><H><L><W><R><S><G><N><K><S><S><P><P><S><I><A><P><L><A><L><D><S><A><D><L><S><E><E><K><G><S><V><Q><M><D><S><T><L><Q><G><D><M><R><H><M><T><L><E><G><E><E><E><N><G><E><V><H><Q><A><R><E><D><K><S><L><S><E><A><P><E><D><T><S><T><R><G><L><N><Q><D><S><T><D><S><K><T><L><Q><E><Q><M><D><E><L><L><Q><Q><C><F><L><H><A><L><K><C><R><V><K><K><A><D><L><P><L><L><T><S><T><F><L><G><S><H><M><F><S><C><C><P><E><G><R><Q><L><D><I><K><K><S><S><Y><K><K><L><S><K><F><L><Q><Q><M><Q><Q><E><Q><I><I><Q><V><K><E><L><S><K><G><V><E><S><I><V><A><V><D><W><K><H><P><R><I><T><S><F><V><I><P><E><P><S><P><T><S><Q><T><I><Q><E><G><S><R><E><Q><P><Y><H><P><P><D><I><K><P><L><Y><C><V><P><A><S><M><T><L><L><F><Q><E><S><G><H><K><K><G><S><F><L><E><G><S><E><V><R><T><I><V><I><N><Y><A><K><K><N><D><L><V><D><A><D><N><K><N><L><V><R><L><D><P><I><L><C><D><C><I><L><E><K><N><E><Q><H><T><V><M><K><L><P><W><D><S><L><L><T><R><C><L><E><K><L><Q><P><A><Y><Q><V><T><L><P><G><Q><E><P><I><V><K><K><G><R><I><C><P><I><D><I><T><L><A><Q><R><A><S><N><K><K><V><T><V><V><R><N><L><E><A><Y><G><L><D><P><Y><S><V><A><A><I><L><Q><Q><R><C><Q><A><S><T><T><V><N><P><A><P><G><A><K><D><S><L><Q><V><Q><I><Q><G><N><Q><V><H><H><L><G><W><L><L><L><E><E><Y><Q><L><P><R><K><H><I><Q><G><L><E><K><A><L><K><P><G><K><K><K>
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Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.<BOP>
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P41214
|
Q16790
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CAH9_HUMAN
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pMW1
|
Homo
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<M><A><P><L><C><P><S><P><W><L><P><L><L><I><P><A><P><A><P><G><L><T><V><Q><L><L><L><S><L><L><L><L><V><P><V><H><P><Q><R><L><P><R><M><Q><E><D><S><P><L><G><G><G><S><S><G><E><D><D><P><L><G><E><E><D><L><P><S><E><E><D><S><P><R><E><E><D><P><P><G><E><E><D><L><P><G><E><E><D><L><P><G><E><E><D><L><P><E><V><K><P><K><S><E><E><E><G><S><L><K><L><E><D><L><P><T><V><E><A><P><G><D><P><Q><E><P><Q><N><N><A><H><R><D><K><E><G><D><D><Q><S><H><W><R><Y><G><G><D><P><P><W><P><R><V><S><P><A><C><A><G><R><F><Q><S><P><V><D><I><R><P><Q><L><A><A><F><C><P><A><L><R><P><L><E><L><L><G><F><Q><L><P><P><L><P><E><L><R><L><R><N><N><G><H><S><V><Q><L><T><L><P><P><G><L><E><M><A><L><G><P><G><R><E><Y><R><A><L><Q><L><H><L><H><W><G><A><A><G><R><P><G><S><E><H><T><V><E><G><H><R><F><P><A><E><I><H><V><V><H><L><S><T><A><F><A><R><V><D><E><A><L><G><R><P><G><G><L><A><V><L><A><A><F><L><E><E><G><P><E><E><N><S><A><Y><E><Q><L><L><S><R><L><E><E><I><A><E><E><G><S><E><T><Q><V><P><G><L><D><I><S><A><L><L><P><S><D><F><S><R><Y><F><Q><Y><E><G><S><L><T><T><P><P><C><A><Q><G><V><I><W><T><V><F><N><Q><T><V><M><L><S><A><K><Q><L><H><T><L><S><D><T><L><W><G><P><G><D><S><R><L><Q><L><N><F><R><A><T><Q><P><L><N><G><R><V><I><E><A><S><F><P><A><G><V><D><S><S><P><R><A><A><E><P><V><Q><L><N><S><C><L><A><A><G><D><I><L><A><L><V><F><G><L><L><F><A><V><T><S><V><A><F><L><V><Q><M><R><R><Q><H><R><R><G><T><K><G><G><V><S><Y><R><P><A><E><V><A><E><T><G><A>
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Catalyzes the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions).<BOP>
|
Q16790
|
O14682
|
ENC1_HUMAN
|
p53-induced gene 10 protein
|
Homo
|
<M><S><V><S><V><H><E><N><R><K><S><R><A><S><S><G><S><I><N><I><Y><L><F><H><K><S><S><Y><A><D><S><V><L><T><H><L><N><L><L><R><Q><Q><R><L><F><T><D><V><L><L><H><A><G><N><R><T><F><P><C><H><R><A><V><L><A><A><C><S><R><Y><F><E><A><M><F><S><G><G><L><K><E><S><Q><D><S><E><V><N><F><D><N><S><I><H><P><E><V><L><E><L><L><L><D><Y><A><Y><S><S><R><V><I><I><N><E><E><N><A><E><S><L><L><E><A><G><D><M><L><E><F><Q><D><I><R><D><A><C><A><E><F><L><E><K><N><L><H><P><T><N><C><L><G><M><L><L><L><S><D><A><H><Q><C><T><K><L><Y><E><L><S><W><R><M><C><L><S><N><F><Q><T><I><R><K><N><E><D><F><L><Q><L><P><Q><D><M><V><V><Q><L><L><S><S><E><E><L><E><T><E><D><E><R><L><V><Y><E><S><A><I><N><W><I><S><Y><D><L><K><K><R><Y><C><Y><L><P><E><L><L><Q><T><V><R><L><A><L><L><P><A><I><Y><L><M><E><N><V><A><M><E><E><L><I><T><K><Q><R><K><S><K><E><I><V><E><E><A><I><R><C><K><L><K><I><L><Q><N><D><G><V><V><T><S><L><C><A><R><P><R><K><T><G><H><A><L><F><L><L><G><G><Q><T><F><M><C><D><K><L><Y><L><V><D><Q><K><A><K><E><I><I><P><K><A><D><I><P><S><P><R><K><E><F><S><A><C><A><I><G><C><K><V><Y><I><T><G><G><R><G><S><E><N><G><V><S><K><D><V><W><V><Y><D><T><L><H><E><E><W><S><K><A><A><P><M><L><V><A><R><F><G><H><G><S><A><E><L><K><H><C><L><Y><V><V><G><G><H><T><A><A><T><G><C><L><P><A><S><P><S><V><S><L><K><Q><V><E><H><Y><D><P><T><I><N><K><W><T><M><V><A><P><L><R><E><G><V><S><N><A><A><V><V><S><A><K><L><K><L><F><A><F><G><G><T><S><V><S><H><D><K><L><P><K><V><Q><C><Y><D><Q><C><E><N><R><W><T><V><P><A><T><C><P><Q><P><W><R><Y><T><A><A><A><V><L><G><N><Q><I><F><I><M><G><G><D><T><E><F><S><A><C><S><A><Y><K><F><N><S><E><T><Y><Q><W><T><K><V><G><D><V><T><A><K><R><M><S><C><H><A><V><A><S><G><N><K><L><Y><V><V><G><G><Y><F><G><I><Q><R><C><K><T><L><D><C><Y><D><P><T><L><D><V><W><N><S><I><T><T><V><P><Y><S><L><I><P><T><A><F><V><S><T><W><K><H><L><P><S>
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Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.<BOP>
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O14682
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Q6UX52
|
IL40_HUMAN
|
Interleukin-40
|
Homo
|
<M><G><L><P><G><L><F><C><L><A><V><L><A><A><S><S><F><S><K><A><R><E><E><E><I><T><P><V><V><S><I><A><Y><K><V><L><E><V><F><P><K><G><R><W><V><L><I><T><C><C><A><P><Q><P><P><P><P><I><T><Y><S><L><C><G><T><K><N><I><K><V><A><K><K><V><V><K><T><H><E><P><A><S><F><N><L><N><V><T><L><K><S><S><P><D><L><L><T><Y><F><C><W><A><S><S><T><S><G><A><H><V><D><S><A><R><L><Q><M><H><W><E><L><W><S><K><P><V><S><E><L><R><A><N><F><T><L><Q><D><R><G><A><G><P><R><V><E><M><I><C><Q><A><S><S><G><S><P><P><I><T><N><S><L><I><G><K><D><G><Q><V><H><L><Q><Q><R><P><C><H><R><Q><P><A><N><F><S><F><L><P><S><Q><T><S><D><W><F><W><C><Q><A><A><N><N><A><N><V><Q><H><S><A><L><T><V><V><P><P><G><G><D><Q><K><M><E><D><W><Q><G><P><L><E><S><P><I><L><A><L><P><L><Y><R><S><T><R><R><L><S><E><E><E><F><G><G><F><R><I><G><N><G><E><V><R><G><R><K><A><A><A><M>
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Probable B cell-associated cytokine that plays a role in the regulation of humoral immune responses. Involved in lymphocyte B cell development and immunoglobulin/IgA production.<BOP>
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Q6UX52
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Q13451
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FKBP5_HUMAN
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Rotamase
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Homo
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<M><T><T><D><E><G><A><K><N><N><E><E><S><P><T><A><T><V><A><E><Q><G><E><D><I><T><S><K><K><D><R><G><V><L><K><I><V><K><R><V><G><N><G><E><E><T><P><M><I><G><D><K><V><Y><V><H><Y><K><G><K><L><S><N><G><K><K><F><D><S><S><H><D><R><N><E><P><F><V><F><S><L><G><K><G><Q><V><I><K><A><W><D><I><G><V><A><T><M><K><K><G><E><I><C><H><L><L><C><K><P><E><Y><A><Y><G><S><A><G><S><L><P><K><I><P><S><N><A><T><L><F><F><E><I><E><L><L><D><F><K><G><E><D><L><F><E><D><G><G><I><I><R><R><T><K><R><K><G><E><G><Y><S><N><P><N><E><G><A><T><V><E><I><H><L><E><G><R><C><G><G><R><M><F><D><C><R><D><V><A><F><T><V><G><E><G><E><D><H><D><I><P><I><G><I><D><K><A><L><E><K><M><Q><R><E><E><Q><C><I><L><Y><L><G><P><R><Y><G><F><G><E><A><G><K><P><K><F><G><I><E><P><N><A><E><L><I><Y><E><V><T><L><K><S><F><E><K><A><K><E><S><W><E><M><D><T><K><E><K><L><E><Q><A><A><I><V><K><E><K><G><T><V><Y><F><K><G><G><K><Y><M><Q><A><V><I><Q><Y><G><K><I><V><S><W><L><E><M><E><Y><G><L><S><E><K><E><S><K><A><S><E><S><F><L><L><A><A><F><L><N><L><A><M><C><Y><L><K><L><R><E><Y><T><K><A><V><E><C><C><D><K><A><L><G><L><D><S><A><N><E><K><G><L><Y><R><R><G><E><A><Q><L><L><M><N><E><F><E><S><A><K><G><D><F><E><K><V><L><E><V><N><P><Q><N><K><A><A><R><L><Q><I><S><M><C><Q><K><K><A><K><E><H><N><E><R><D><R><R><I><Y><A><N><M><F><K><K><F><A><E><Q><D><A><K><E><E><A><N><K><A><M><G><K><K><T><S><E><G><V><T><N><E><K><G><T><D><S><Q><A><M><E><E><E><K><P><E><G><H><V>
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Immunophilin protein with PPIase and co-chaperone activities . Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded . Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 . Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production .<BOP>
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Q13451
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O43687
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AKA7A_HUMAN
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Protein kinase A-anchoring protein 7 isoforms alpha/beta
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Homo
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<M><G><Q><L><C><C><F><P><F><S><R><D><E><G><K><I><S><E><L><E><S><S><S><S><A><V><L><Q><R><Y><S><K><D><I><P><S><W><S><S><G><E><K><N><G><G><E><P><D><D><A><E><L><V><R><L><S><K><R><L><V><E><N><A><V><L><K><A><V><Q><Q><Y><L><E><E><T><Q><N><K><N><K><P><G><E><G><S><S><V><K><T><E><A><A><D><Q><N><G><N><D><N><E><N><N><R><K>
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Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.<BOP>
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O43687
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O43820
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HYAL3_HUMAN
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Lung carcinoma protein 3
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Homo
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<M><T><T><Q><L><G><P><A><L><V><L><G><V><A><L><C><L><G><C><G><Q><P><L><P><Q><V><P><E><R><P><F><S><V><L><W><N><V><P><S><A><H><C><E><A><R><F><G><V><H><L><P><L><N><A><L><G><I><I><A><N><R><G><Q><H><F><H><G><Q><N><M><T><I><F><Y><K><N><Q><L><G><L><Y><P><Y><F><G><P><R><G><T><A><H><N><G><G><I><P><Q><A><L><P><L><D><R><H><L><A><L><A><A><Y><Q><I><H><H><S><L><R><P><G><F><A><G><P><A><V><L><D><W><E><E><W><C><P><L><W><A><G><N><W><G><R><R><R><A><Y><Q><A><A><S><W><A><W><A><Q><Q><V><F><P><D><L><D><P><Q><E><Q><L><Y><K><A><Y><T><G><F><E><Q><A><A><R><A><L><M><E><D><T><L><R><V><A><Q><A><L><R><P><H><G><L><W><G><F><Y><H><Y><P><A><C><G><N><G><W><H><S><M><A><S><N><Y><T><G><R><C><H><A><A><T><L><A><R><N><T><Q><L><H><W><L><W><A><A><S><S><A><L><F><P><S><I><Y><L><P><P><R><L><P><P><A><H><H><Q><A><F><V><R><H><R><L><E><E><A><F><R><V><A><L><V><G><H><R><H><P><L><P><V><L><A><Y><V><R><L><T><H><R><R><S><G><R><F><L><S><Q><D><D><L><V><Q><S><I><G><V><S><A><A><L><G><A><A><G><V><V><L><W><G><D><L><S><L><S><S><S><E><E><E><C><W><H><L><H><D><Y><L><V><D><T><L><G><P><Y><V><I><N><V><T><R><A><A><M><A><C><S><H><Q><R><C><H><G><H><G><R><C><A><R><R><D><P><G><Q><M><E><A><F><L><H><L><W><P><D><G><S><L><G><D><W><K><S><F><S><C><H><C><Y><W><G><W><A><G><P><T><C><Q><E><P><R><P><G><P><K><E><A><V>
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Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro.<BOP>
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O43820
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P17844
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DDX5_HUMAN
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RNA helicase p68
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Homo
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<M><S><G><Y><S><S><D><R><D><R><G><R><D><R><G><F><G><A><P><R><F><G><G><S><R><A><G><P><L><S><G><K><K><F><G><N><P><G><E><K><L><V><K><K><K><W><N><L><D><E><L><P><K><F><E><K><N><F><Y><Q><E><H><P><D><L><A><R><R><T><A><Q><E><V><E><T><Y><R><R><S><K><E><I><T><V><R><G><H><N><C><P><K><P><V><L><N><F><Y><E><A><N><F><P><A><N><V><M><D><V><I><A><R><Q><N><F><T><E><P><T><A><I><Q><A><Q><G><W><P><V><A><L><S><G><L><D><M><V><G><V><A><Q><T><G><S><G><K><T><L><S><Y><L><L><P><A><I><V><H><I><N><H><Q><P><F><L><E><R><G><D><G><P><I><C><L><V><L><A><P><T><R><E><L><A><Q><Q><V><Q><Q><V><A><A><E><Y><C><R><A><C><R><L><K><S><T><C><I><Y><G><G><A><P><K><G><P><Q><I><R><D><L><E><R><G><V><E><I><C><I><A><T><P><G><R><L><I><D><F><L><E><C><G><K><T><N><L><R><R><T><T><Y><L><V><L><D><E><A><D><R><M><L><D><M><G><F><E><P><Q><I><R><K><I><V><D><Q><I><R><P><D><R><Q><T><L><M><W><S><A><T><W><P><K><E><V><R><Q><L><A><E><D><F><L><K><D><Y><I><H><I><N><I><G><A><L><E><L><S><A><N><H><N><I><L><Q><I><V><D><V><C><H><D><V><E><K><D><E><K><L><I><R><L><M><E><E><I><M><S><E><K><E><N><K><T><I><V><F><V><E><T><K><R><R><C><D><E><L><T><R><K><M><R><R><D><G><W><P><A><M><G><I><H><G><D><K><S><Q><Q><E><R><D><W><V><L><N><E><F><K><H><G><K><A><P><I><L><I><A><T><D><V><A><S><R><G><L><D><V><E><D><V><K><F><V><I><N><Y><D><Y><P><N><S><S><E><D><Y><I><H><R><I><G><R><T><A><R><S><T><K><T><G><T><A><Y><T><F><F><T><P><N><N><I><K><Q><V><S><D><L><I><S><V><L><R><E><A><N><Q><A><I><N><P><K><L><L><Q><L><V><E><D><R><G><S><G><R><S><R><G><R><G><G><M><K><D><D><R><R><D><R><Y><S><A><G><K><R><G><G><F><N><T><F><R><D><R><E><N><Y><D><R><G><Y><S><S><L><L><K><R><D><F><G><A><K><T><Q><N><G><V><Y><S><A><A><N><Y><T><N><G><S><F><G><S><N><F><V><S><A><G><I><Q><T><S><F><R><T><G><N><P><T><G><T><Y><Q><N><G><Y><D><S><T><Q><Q><Y><G><S><N><V><P><N><M><H><N><G><M><N><Q><Q><A><Y><A><Y><P><A><T><A><A><A><P><M><I><G><Y><P><M><P><T><G><Y><S><Q>
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Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes
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P17844
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Q9Y6G5
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COMDA_HUMAN
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COMM domain-containing protein 10
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Homo
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<M><A><V><P><A><A><L><I><L><R><E><S><P><S><M><K><K><A><V><S><L><I><N><A><I><D><T><G><R><F><P><R><L><L><T><R><I><L><Q><K><L><H><L><K><A><E><S><S><F><S><E><E><E><E><E><K><L><Q><A><A><F><S><L><E><K><Q><D><L><H><L><V><L><E><T><I><S><F><I><L><E><Q><A><V><Y><H><N><V><K><P><A><A><L><Q><Q><Q><L><E><N><I><H><L><R><Q><D><K><A><E><A><F><V><N><T><W><S><S><M><G><Q><E><T><V><E><K><F><R><Q><R><I><L><A><P><C><K><L><E><T><V><G><W><Q><L><N><L><Q><M><A><H><S><A><Q><A><K><L><K><S><P><Q><A><V><L><Q><L><G><V><N><N><E><D><S><K><S><L><E><K><V><L><V><E><F><S><H><K><E><L><F><D><F><Y><N><K><L><E><T><I><Q><A><Q><L><D><S><L><T>
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May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes . May down-regulate activation of NF-kappa-B .<BOP>
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Q9Y6G5
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Q9Y6I4
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UBP3_HUMAN
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Ubiquitin-specific-processing protease 3
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Homo
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<M><E><C><P><H><L><S><S><S><V><C><I><A><P><D><S><A><K><F><P><N><G><S><P><S><S><W><C><C><S><V><C><R><S><N><K><S><P><W><V><C><L><T><C><S><S><V><H><C><G><R><Y><V><N><G><H><A><K><K><H><Y><E><D><A><Q><V><P><L><T><N><H><K><K><S><E><K><Q><D><K><V><Q><H><T><V><C><M><D><C><S><S><Y><S><T><Y><C><Y><R><C><D><D><F><V><V><N><D><T><K><L><G><L><V><Q><K><V><R><E><H><L><Q><N><L><E><N><S><A><F><T><A><D><R><H><K><K><R><K><L><L><E><N><S><T><L><N><S><K><L><L><K><V><N><G><S><T><T><A><I><C><A><T><G><L><R><N><L><G><N><T><C><F><M><N><A><I><L><Q><S><L><S><N><I><E><Q><F><C><C><Y><F><K><E><L><P><A><V><E><L><R><N><G><K><T><A><G><R><R><T><Y><H><T><R><S><Q><G><D><N><N><V><S><L><V><E><E><F><R><K><T><L><C><A><L><W><Q><G><S><Q><T><A><F><S><P><E><S><L><F><Y><V><V><W><K><I><M><P><N><F><R><G><Y><Q><Q><Q><D><A><H><E><F><M><R><Y><L><L><D><H><L><H><L><E><L><Q><G><G><F><N><G><V><S><R><S><A><I><L><Q><E><N><S><T><L><S><A><S><N><K><C><C><I><N><G><A><S><T><V><V><T><A><I><F><G><G><I><L><Q><N><E><V><N><C><L><I><C><G><T><E><S><R><K><F><D><P><F><L><D><L><S><L><D><I><P><S><Q><F><R><S><K><R><S><K><N><Q><E><N><G><P><V><C><S><L><R><D><C><L><R><S><F><T><D><L><E><E><L><D><E><T><E><L><Y><M><C><H><K><C><K><K><K><Q><K><S><T><K><K><F><W><I><Q><K><L><P><K><V><L><C><L><H><L><K><R><F><H><W><T><A><Y><L><R><N><K><V><D><T><Y><V><E><F><P><L><R><G><L><D><M><K><C><Y><L><L><E><P><E><N><S><G><P><E><S><C><L><Y><D><L><A><A><V><V><V><H><H><G><S><G><V><G><S><G><H><Y><T><A><Y><A><T><H><E><G><R><W><F><H><F><N><D><S><T><V><T><L><T><D><E><E><T><V><V><K><A><K><A><Y><I><L><F><Y><V><E><H><Q><A><K><A><G><S><D><K><L>
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Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.<BOP>
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Q9Y6I4
|
Q8TDG2
|
ACTT1_HUMAN
|
Actin-related protein T1
|
Homo
|
<M><F><N><P><H><A><L><D><V><P><A><V><I><F><D><N><G><S><G><L><C><K><A><G><L><S><G><E><I><G><P><R><H><V><I><S><S><V><L><G><H><C><K><F><N><V><P><L><A><R><L><N><Q><K><Y><F><V><G><Q><E><A><L><Y><K><Y><E><A><L><H><L><H><Y><P><I><E><R><G><L><V><T><G><W><D><D><M><E><K><L><W><K><H><L><F><E><R><E><L><G><V><K><P><S><Q><Q><P><V><L><M><T><E><P><S><L><N><P><R><E><I><R><E><K><L><A><E><M><M><F><E><T><F><S><V><P><G><F><Y><L><S><N><H><A><V><A><A><L><Y><A><S><A><C><V><T><G><L><V><V><D><S><G><D><G><V><T><C><T><V><P><I><F><E><G><Y><S><L><P><H><A><V><T><K><L><C><M><A><G><R><D><I><T><E><H><L><T><R><L><L><F><A><S><G><F><N><F><P><C><I><L><N><K><A><V><V><N><N><I><K><E><K><L><C><Y><I><A><L><E><P><E><K><E><L><R><K><S><R><G><E><V><L><G><A><Y><R><L><P><D><G><H><V><I><H><F><G><D><E><L><Y><Q><V><P><E><V><L><F><A><P><D><Q><L><G><I><H><S><P><G><L><S><K><M><V><S><S><S><I><M><K><C><D><T><D><I><Q><N><K><L><Y><A><D><I><V><L><S><G><G><T><T><L><L><P><G><L><E><E><R><L><M><K><E><V><E><Q><L><A><S><K><G><T><P><I><K><I><T><A><S><P><D><R><C><F><S><A><W><I><G><A><S><I><M><T><S><M><S><S><F><K><Q><M><W><V><T><S><A><D><F><K><E><Y><G><T><S><V><V><Q><R><R><C><F>
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Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression.<BOP>
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Q8TDG2
|
P60827
|
C1QT8_HUMAN
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C1q/TNF-related protein 8
|
Homo
|
<M><A><A><P><A><L><L><L><L><A><L><L><L><P><V><G><A><W><P><G><L><P><R><R><P><C><V><H><C><C><R><P><A><W><P><P><G><P><Y><A><R><V><S><D><R><D><L><W><R><G><D><L><W><R><G><L><P><R><V><R><P><T><I><D><I><E><I><L><K><G><E><K><G><E><A><G><V><R><G><R><A><G><R><S><G><K><E><G><P><P><G><A><R><G><L><Q><G><R><R><G><Q><K><G><Q><V><G><P><P><G><A><A><C><R><R><A><Y><A><A><F><S><V><G><R><R><E><G><L><H><S><S><D><H><F><Q><A><V><P><F><D><T><E><L><V><N><L><D><G><A><F><D><L><A><A><G><R><F><L><C><T><V><P><G><V><Y><F><L><S><L><N><V><H><T><W><N><Y><K><E><T><Y><L><H><I><M><L><N><R><R><P><A><A><V><L><Y><A><Q><P><S><E><R><S><V><M><Q><A><Q><S><L><M><L><L><L><A><A><G><D><A><V><W><V><R><M><F><Q><R><D><R><D><N><A><I><Y><G><E><H><G><D><L><Y><I><T><F><S><G><H><L><V><K><P><A><A><E><L>
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May play a role as ligand of RXFP1.<BOP>
|
P60827
|
O95551
|
TYDP2_HUMAN
|
VPg unlinkase
|
Homo
|
<M><E><L><G><S><C><L><E><G><G><R><E><A><A><E><E><E><G><E><P><E><V><K><K><R><R><L><L><C><V><E><F><A><S><V><A><S><C><D><A><A><V><A><Q><C><F><L><A><E><N><D><W><E><M><E><R><A><L><N><S><Y><F><E><P><P><V><E><E><S><A><L><E><R><R><P><E><T><I><S><E><P><K><T><Y><V><D><L><T><N><E><E><T><T><D><S><T><T><S><K><I><S><P><S><E><D><T><Q><Q><E><N><G><S><M><F><S><L><I><T><W><N><I><D><G><L><D><L><N><N><L><S><E><R><A><R><G><V><C><S><Y><L><A><L><Y><S><P><D><V><I><F><L><Q><E><V><I><P><P><Y><Y><S><Y><L><K><K><R><S><S><N><Y><E><I><I><T><G><H><E><E><G><Y><F><T><A><I><M><L><K><K><S><R><V><K><L><K><S><Q><E><I><I><P><F><P><S><T><K><M><M><R><N><L><L><C><V><H><V><N><V><S><G><N><E><L><C><L><M><T><S><H><L><E><S><T><R><G><H><A><A><E><R><M><N><Q><L><K><M><V><L><K><K><M><Q><E><A><P><E><S><A><T><V><I><F><A><G><D><T><N><L><R><D><R><E><V><T><R><C><G><G><L><P><N><N><I><V><D><V><W><E><F><L><G><K><P><K><H><C><Q><Y><T><W><D><T><Q><M><N><S><N><L><G><I><T><A><A><C><K><L><R><F><D><R><I><F><F><R><A><A><A><E><E><G><H><I><I><P><R><S><L><D><L><L><G><L><E><K><L><D><C><G><R><F><P><S><D><H><W><G><L><L><C><N><L><D><I><I><L>
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(Microbial infection) Also acts as a 5'-tyrosyl-RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and acts by specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infection, without impairing the integrity of viral RNA.<BOP>
|
O95551
|
O76050
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NEUL1_HUMAN
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RING-type E3 ubiquitin transferase NEURL1
|
Homo
|
<M><G><N><N><F><S><S><I><P><S><L><P><R><G><N><P><S><R><A><P><R><G><H><P><Q><N><L><K><D><S><I><G><G><P><F><P><V><T><S><H><R><C><H><H><K><Q><K><H><C><P><A><V><L><P><S><G><G><L><P><A><T><P><L><L><F><H><P><H><T><K><G><S><Q><I><L><M><D><L><S><H><K><A><V><K><R><Q><A><S><F><C><N><A><I><T><F><S><N><R><P><V><L><I><Y><E><Q><V><R><L><K><I><T><K><K><Q><C><C><W><S><G><A><L><R><L><G><F><T><S><K><D><P><S><R><I><H><P><D><S><L><P><K><Y><A><C><P><D><L><V><S><Q><S><G><F><W><A><K><A><L><P><E><E><F><A><N><E><G><N><I><I><A><F><W><V><D><K><K><G><R><V><F><H><R><I><N><D><S><A><V><M><L><F><F><S><G><V><R><T><A><D><P><L><W><A><L><V><D><V><Y><G><L><T><R><G><V><Q><L><L><D><S><E><L><V><L><P><D><C><L><R><P><R><S><F><T><A><L><R><R><P><S><L><R><R><E><A><D><D><A><R><L><S><V><S><L><C><D><L><N><V><P><G><A><D><G><D><E><A><A><P><A><A><G><C><P><I><P><Q><N><S><L><N><S><Q><H><S><R><A><L><P><A><Q><L><D><G><D><L><R><F><H><A><L><R><A><G><A><H><V><R><I><L><D><E><Q><T><V><A><R><V><E><H><G><R><D><E><R><A><L><V><F><T><S><R><P><V><R><V><A><E><T><I><F><V><K><V><T><R><S><G><G><A><R><P><G><A><L><S><F><G><V><T><T><C><D><P><G><T><L><R><P><A><D><L><P><F><S><P><E><A><L><V><D><R><K><E><F><W><A><V><C><R><V><P><G><P><L><H><S><G><D><I><L><G><L><V><V><N><A><D><G><E><L><H><L><S><H><N><G><A><A><A><G><M><Q><L><C><V><D><A><S><Q><P><L><W><M><L><F><G><L><H><G><T><I><T><Q><I><R><I><L><G><S><T><I><L><A><E><R><G><I><P><S><L><P><C><S><P><A><S><T><P><T><S><P><S><A><L><G><S><R><L><S><D><P><L><L><S><T><C><S><S><G><P><L><G><S><S><A><G><G><T><A><P><N><S><P><V><S><L><P><E><S><P><V><T><P><G><L><G><Q><W><S><D><E><C><T><I><C><Y><E><H><A><V><D><T><V><I><Y><T><C><G><H><M><C><L><C><Y><A><C><G><L><R><L><K><K><A><L><H><A><C><C><P><I><C><R><R><P><I><K><D><I><I><K><T><Y><R><S><S>
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Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.<BOP>
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O76050
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A8MTJ6
|
FOXI3_HUMAN
|
Forkhead box protein I3
|
Homo
|
<M><A><L><Y><C><G><D><N><F><G><V><Y><S><Q><P><G><L><P><P><P><A><A><T><A><A><A><P><G><A><P><P><A><A><R><A><P><Y><G><L><A><D><Y><A><A><P><P><A><A><A><A><N><P><Y><L><W><L><N><G><P><G><V><G><G><P><P><S><A><A><A><A><A><A><A><A><Y><L><G><A><P><P><P><P><P><P><P><G><A><A><A><G><P><F><L><Q><P><P><P><A><A><G><T><F><G><C><S><Q><R><P><F><A><Q><P><A><P><A><A><P><A><S><P><A><A><P><A><G><P><G><E><L><G><W><L><S><M><A><S><R><E><D><L><M><K><M><V><R><P><P><Y><S><Y><S><A><L><I><A><M><A><I><Q><S><A><P><E><R><K><L><T><L><S><H><I><Y><Q><F><V><A><D><S><F><P><F><Y><Q><R><S><K><A><G><W><Q><N><S><I><R><H><N><L><S><L><N><D><C><F><K><K><V><P><R><D><E><D><D><P><G><K><G><N><Y><W><T><L><D><P><N><C><E><K><M><F><D><N><G><N><F><R><R><K><R><K><R><R><S><E><A><S><N><G><S><T><V><A><A><G><T><S><K><S><E><E><G><L><S><S><G><L><G><S><G><V><G><G><K><P><E><E><E><S><P><S><T><L><L><R><P><S><H><S><P><E><P><P><E><G><T><K><S><T><A><S><S><P><G><G><P><M><L><T><S><T><P><C><L><N><T><F><F><S><S><L><S><S><L><S><V><S><S><S><V><S><T><Q><R><A><L><P><G><S><R><H><L><G><I><Q><G><A><Q><L><P><S><S><G><V><F><S><P><T><S><I><S><E><A><S><A><D><T><L><Q><L><S><N><S><T><S><N><S><T><G><Q><R><S><S><Y><Y><S><P><F><P><A><S><T><S><G><G><Q><S><S><P><F><S><S><P><F><H><N><F><S><M><V><N><S><L><I><Y><P><R><E><G><S><E><V>
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Possible transcriptional factor.<BOP>
|
A8MTJ6
|
P20813
|
CP2B6_HUMAN
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Cytochrome P450 IIB1
|
Homo
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<M><E><L><S><V><L><L><F><L><A><L><L><T><G><L><L><L><L><L><V><Q><R><H><P><N><T><H><D><R><L><P><P><G><P><R><P><L><P><L><L><G><N><L><L><Q><M><D><R><R><G><L><L><K><S><F><L><R><F><R><E><K><Y><G><D><V><F><T><V><H><L><G><P><R><P><V><V><M><L><C><G><V><E><A><I><R><E><A><L><V><D><K><A><E><A><F><S><G><R><G><K><I><A><M><V><D><P><F><F><R><G><Y><G><V><I><F><A><N><G><N><R><W><K><V><L><R><R><F><S><V><T><T><M><R><D><F><G><M><G><K><R><S><V><E><E><R><I><Q><E><E><A><Q><C><L><I><E><E><L><R><K><S><K><G><A><L><M><D><P><T><F><L><F><Q><S><I><T><A><N><I><I><C><S><I><V><F><G><K><R><F><H><Y><Q><D><Q><E><F><L><K><M><L><N><L><F><Y><Q><T><F><S><L><I><S><S><V><F><G><Q><L><F><E><L><F><S><G><F><L><K><Y><F><P><G><A><H><R><Q><V><Y><K><N><L><Q><E><I><N><A><Y><I><G><H><S><V><E><K><H><R><E><T><L><D><P><S><A><P><K><D><L><I><D><T><Y><L><L><H><M><E><K><E><K><S><N><A><H><S><E><F><S><H><Q><N><L><N><L><N><T><L><S><L><F><F><A><G><T><E><T><T><S><T><T><L><R><Y><G><F><L><L><M><L><K><Y><P><H><V><A><E><R><V><Y><R><E><I><E><Q><V><I><G><P><H><R><P><P><E><L><H><D><R><A><K><M><P><Y><T><E><A><V><I><Y><E><I><Q><R><F><S><D><L><L><P><M><G><V><P><H><I><V><T><Q><H><T><S><F><R><G><Y><I><I><P><K><D><T><E><V><F><L><I><L><S><T><A><L><H><D><P><H><Y><F><E><K><P><D><A><F><N><P><D><H><F><L><D><A><N><G><A><L><K><K><T><E><A><F><I><P><F><S><L><G><K><R><I><C><L><G><E><G><I><A><R><A><E><L><F><L><F><F><T><T><I><L><Q><N><F><S><M><A><S><P><V><A><P><E><D><I><D><L><T><P><Q><E><C><G><V><G><K><I><P><P><T><Y><Q><I><R><F><L><P><R>
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Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs.<BOP>
|
P20813
|
Q9UBC0
|
HNF6_HUMAN
|
One cut homeobox 1
|
Homo
|
<M><N><A><Q><L><T><M><E><A><I><G><E><L><H><G><V><S><H><E><P><V><P><A><P><A><D><L><L><G><G><S><P><H><A><R><S><S><V><A><H><R><G><S><H><L><P><P><A><H><P><R><S><M><G><M><A><S><L><L><D><G><G><S><G><G><G><D><Y><H><H><H><H><R><A><P><E><H><S><L><A><G><P><L><H><P><T><M><T><M><A><C><E><T><P><P><G><M><S><M><P><T><T><Y><T><T><L><T><P><L><Q><P><L><P><P><I><S><T><V><S><D><K><F><P><H><H><H><H><H><H><H><H><H><H><H><P><H><H><H><Q><R><L><A><G><N><V><S><G><S><F><T><L><M><R><D><E><R><G><L><A><S><M><N><N><L><Y><T><P><Y><H><K><D><V><A><G><M><G><Q><S><L><S><P><L><S><S><S><G><L><G><S><I><H><N><S><Q><Q><G><L><P><H><Y><A><H><P><G><A><A><M><P><T><D><K><M><L><T><P><N><G><F><E><A><H><H><P><A><M><L><G><R><H><G><E><Q><H><L><T><P><T><S><A><G><M><V><P><I><N><G><L><P><P><H><H><P><H><A><H><L><N><A><Q><G><H><G><Q><L><L><G><T><A><R><E><P><N><P><S><V><T><G><A><Q><V><S><N><G><S><N><S><G><Q><M><E><E><I><N><T><K><E><V><A><Q><R><I><T><T><E><L><K><R><Y><S><I><P><Q><A><I><F><A><Q><R><V><L><C><R><S><Q><G><T><L><S><D><L><L><R><N><P><K><P><W><S><K><L><K><S><G><R><E><T><F><R><R><M><W><K><W><L><Q><E><P><E><F><Q><R><M><S><A><L><R><L><A><A><C><K><R><K><E><Q><E><H><G><K><D><R><G><N><T><P><K><K><P><R><L><V><F><T><D><V><Q><R><R><T><L><H><A><I><F><K><E><N><K><R><P><S><K><E><L><Q><I><T><I><S><Q><Q><L><G><L><E><L><S><T><V><S><N><F><F><M><N><A><R><R><R><S><L><D><K><W><Q><D><E><G><S><S><N><S><G><N><S><S><S><S><S><S><T><C><T><K><A>
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Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.<BOP>
|
Q9UBC0
|
O60359
|
CCG3_HUMAN
|
Transmembrane AMPAR regulatory protein gamma-3
|
Homo
|
<M><R><M><C><D><R><G><I><Q><M><L><I><T><T><V><G><A><F><A><A><F><S><L><M><T><I><A><V><G><T><D><Y><W><L><Y><S><R><G><V><C><R><T><K><S><T><S><D><N><E><T><S><R><K><N><E><E><V><M><T><H><S><G><L><W><R><T><C><C><L><E><G><A><F><R><G><V><C><K><K><I><D><H><F><P><E><D><A><D><Y><E><Q><D><T><A><E><Y><L><L><R><A><V><R><A><S><S><V><F><P><I><L><S><V><T><L><L><F><F><G><G><L><C><V><A><A><S><E><F><H><R><S><R><H><N><V><I><L><S><A><G><I><F><F><V><S><A><G><L><S><N><I><I><G><I><I><V><Y><I><S><A><N><A><G><D><P><G><Q><R><D><S><K><K><S><Y><S><Y><G><W><S><F><Y><F><G><A><F><S><F><I><I><A><E><I><V><G><V><V><A><V><H><I><Y><I><E><K><H><Q><Q><L><R><A><K><S><H><S><E><F><L><K><K><S><T><F><A><R><L><P><P><Y><R><Y><R><F><R><R><R><S><S><S><R><S><T><E><P><R><S><R><D><L><S><P><I><S><K><G><F><H><T><I><P><S><T><D><I><S><M><F><T><L><S><R><D><P><S><K><I><T><M><G><T><L><L><N><S><D><R><D><H><A><F><L><Q><F><H><N><S><T><P><K><E><F><K><E><S><L><H><N><N><P><A><N><R><R><T><T><P><V>
|
Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.<BOP>
|
O60359
|
Q9Y2T5
|
GPR52_HUMAN
|
G-protein coupled receptor 52
|
Homo
|
<M><N><E><S><R><W><T><E><W><R><I><L><N><M><S><S><G><I><V><N><V><S><E><R><H><S><C><P><L><G><F><G><H><Y><S><V><V><D><V><C><I><F><E><T><V><V><I><V><L><L><T><F><L><I><I><A><G><N><L><T><V><I><F><V><F><H><C><A><P><L><L><H><H><Y><T><T><S><Y><F><I><Q><T><M><A><Y><A><D><L><F><V><G><V><S><C><L><V><P><T><L><S><L><L><H><Y><S><T><G><V><H><E><S><L><T><C><Q><V><F><G><Y><I><I><S><V><L><K><S><V><S><M><A><C><L><A><C><I><S><V><D><R><Y><L><A><I><T><K><P><L><S><Y><N><Q><L><V><T><P><C><R><L><R><I><C><I><I><L><I><W><I><Y><S><C><L><I><F><L><P><S><F><F><G><W><G><K><P><G><Y><H><G><D><I><F><E><W><C><A><T><S><W><L><T><S><A><Y><F><T><G><F><I><V><C><L><L><Y><A><P><A><A><F><V><V><C><F><T><Y><F><H><I><F><K><I><C><R><Q><H><T><K><E><I><N><D><R><R><A><R><F><P><S><H><E><V><D><S><S><R><E><T><G><H><S><P><D><R><R><Y><A><M><V><L><F><R><I><T><S><V><F><Y><M><L><W><L><P><Y><I><I><Y><F><L><L><E><S><S><R><V><L><D><N><P><T><L><S><F><L><T><T><W><L><A><I><S><N><S><F><C><N><C><V><I><Y><S><L><S><N><S><V><F><R><L><G><L><R><R><L><S><E><T><M><C><T><S><C><M><C><V><K><D><Q><E><A><Q><E><P><K><P><R><K><R><A><N><S><C><S><I>
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Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization . May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum . Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation .<BOP>
|
Q9Y2T5
|
Q8NCD3
|
HJURP_HUMAN
|
Up-regulated in lung cancer 9
|
Homo
|
<M><L><G><T><L><R><A><M><E><G><E><D><V><E><D><D><Q><L><L><Q><K><L><R><A><S><R><R><R><F><Q><R><R><M><Q><R><L><I><E><K><Y><N><Q><P><F><E><D><T><P><V><V><Q><M><A><T><L><T><Y><E><T><P><Q><G><L><R><I><W><G><G><R><L><I><K><E><R><N><E><G><E><I><Q><D><S><S><M><K><P><A><D><R><T><D><G><S><V><Q><A><A><A><W><G><P><E><L><P><S><H><R><T><V><L><G><A><D><S><K><S><G><E><V><D><A><T><S><D><Q><E><E><S><V><A><W><A><L><A><P><A><V><P><Q><S><P><L><K><N><E><L><R><R><K><Y><L><T><Q><V><D><I><L><L><Q><G><A><E><Y><F><E><C><A><G><N><R><A><G><R><D><V><R><V><T><P><L><P><S><L><A><S><P><A><V><P><A><P><G><Y><C><S><R><I><S><R><K><S><P><G><D><P><A><K><P><A><S><S><P><R><E><W><D><P><L><H><P><S><S><T><D><M><A><L><V><P><R><N><D><S><L><S><L><Q><E><T><S><S><S><S><F><L><S><S><Q><P><F><E><D><D><D><I><C><N><V><T><I><S><D><L><Y><A><G><M><L><H><S><M><S><R><L><L><S><T><K><P><S><S><I><I><S><T><K><T><F><I><M><Q><N><W><N><S><R><R><R><H><R><Y><K><S><R><M><N><K><T><Y><C><K><G><A><R><R><S><Q><R><S><S><K><E><N><F><I><P><C><S><E><P><V><K><G><T><G><A><L><R><D><C><K><N><V><L><D><V><S><C><R><K><T><G><L><K><L><E><K><A><F><L><E><V><N><R><P><Q><I><H><K><L><D><P><S><W><K><E><R><K><V><T><P><S><K><Y><S><S><L><I><Y><F><D><S><S><A><T><Y><N><L><D><E><E><N><R><F><R><T><L><K><W><L><I><S><P><V><K><I><V><S><R><P><T><I><R><Q><G><H><G><E><N><R><Q><R><E><I><E><I><R><F><D><Q><L><H><R><E><Y><C><L><S><P><R><N><Q><P><R><R><M><C><L><P><D><S><W><A><M><N><M><Y><R><G><G><P><A><S><P><G><G><L><Q><G><L><E><T><R><R><L><S><L><P><S><S><K><A><K><A><K><S><L><S><E><A><F><E><N><L><G><K><R><S><L><E><A><G><R><C><L><P><K><S><D><S><S><S><S><L><P><K><T><N><P><T><H><S><A><T><R><P><Q><Q><T><S><D><L><H><V><Q><G><N><S><S><G><I><F><R><K><S><V><S><P><S><K><T><L><S><V><P><D><K><E><V><P><G><H><G><R><N><R><Y><D><E><I><K><E><E><F><D><K><L><H><Q><K><Y><C><L><K><S><P><G><Q><M><T><V><P><L><C><I><G><V><S><T><D><K><A><S><M><E><V><R><Y><Q><T><E><G><F><L><G><K><L><N><P><D><P><H><F><Q><G><F><Q><K><L><P><S><S><P><L><G><C><R><K><S><L><L><G><S><T><A><I><E><A><P><S><S><T><C><V><A><R><A><I><T><R><D><G><T><R><D><H><Q><F><P><A><K><R><P><R><L><S><E><P><Q><G><S><G><R><Q><G><N><S><L><G><A><S><D><G><V><D><N><T><V><R><P><G><D><Q><G><S><S><S><Q><P><N><S><E><E><R><G><E><N><T><S><Y><R><M><E><E><K><S><D><F><M><L><E><K><L><E><T><K><S><V>
|
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.<BOP>
|
Q8NCD3
|
Q8N5K1
|
CISD2_HUMAN
|
Nutrient-deprivation autophagy factor-1
|
Homo
|
<M><V><L><E><S><V><A><R><I><V><K><V><Q><L><P><A><Y><L><K><R><L><P><V><P><E><S><I><T><G><F><A><R><L><T><V><S><E><W><L><R><L><L><P><F><L><G><V><L><A><L><L><G><Y><L><A><V><R><P><F><L><P><K><K><K><Q><Q><K><D><S><L><I><N><L><K><I><Q><K><E><N><P><K><V><V><N><E><I><N><I><E><D><L><C><L><T><K><A><A><Y><C><R><C><W><R><S><K><T><F><P><A><C><D><G><S><H><N><K><H><N><E><L><T><G><D><N><V><G><P><L><I><L><K><K><K><E><V>
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Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.<BOP>
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Q8N5K1
|
Q9BYR6
|
KRA33_HUMAN
|
Keratin-associated protein 3.3
|
Homo
|
<M><D><C><C><A><S><R><G><C><S><V><P><T><G><P><A><T><T><I><C><S><S><D><K><S><C><R><C><G><V><C><L><P><S><T><C><P><H><T><V><W><L><L><E><P><T><C><C><D><N><C><P><P><P><C><H><I><P><Q><P><C><V><P><T><C><F><L><L><N><S><C><Q><P><T><P><G><L><E><T><L><N><L><T><T><F><T><Q><P><C><C><E><P><C><L><P><R><G><C>
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In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
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Q9BYR6
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O95243
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MBD4_HUMAN
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Mismatch-specific DNA N-glycosylase
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Homo
|
<M><G><T><T><G><L><E><S><L><S><L><G><D><R><G><A><A><P><T><V><T><S><S><E><R><L><V><P><D><P><P><N><D><L><R><K><E><D><V><A><M><E><L><E><R><V><G><E><D><E><E><Q><M><M><I><K><R><S><S><E><C><N><P><L><L><Q><E><P><I><A><S><A><Q><F><G><A><T><A><G><T><E><C><R><K><S><V><P><C><G><W><E><R><V><V><K><Q><R><L><F><G><K><T><A><G><R><F><D><V><Y><F><I><S><P><Q><G><L><K><F><R><S><K><S><S><L><A><N><Y><L><H><K><N><G><E><T><S><L><K><P><E><D><F><D><F><T><V><L><S><K><R><G><I><K><S><R><Y><K><D><C><S><M><A><A><L><T><S><H><L><Q><N><Q><S><N><N><S><N><W><N><L><R><T><R><S><K><C><K><K><D><V><F><M><P><P><S><S><S><S><E><L><Q><E><S><R><G><L><S><N><F><T><S><T><H><L><L><L><K><E><D><E><G><V><D><D><V><N><F><R><K><V><R><K><P><K><G><K><V><T><I><L><K><G><I><P><I><K><K><T><K><K><G><C><R><K><S><C><S><G><F><V><Q><S><D><S><K><R><E><S><V><C><N><K><A><D><A><E><S><E><P><V><A><Q><K><S><Q><L><D><R><T><V><C><I><S><D><A><G><A><C><G><E><T><L><S><V><T><S><E><E><N><S><L><V><K><K><K><E><R><S><L><S><S><G><S><N><F><C><S><E><Q><K><T><S><G><I><I><N><K><F><C><S><A><K><D><S><E><H><N><E><K><Y><E><D><T><F><L><E><S><E><E><I><G><T><K><V><E><V><V><E><R><K><E><H><L><H><T><D><I><L><K><R><G><S><E><M><D><N><N><C><S><P><T><R><K><D><F><T><G><E><K><I><F><Q><E><D><T><I><P><R><T><Q><I><E><R><R><K><T><S><L><Y><F><S><S><K><Y><N><K><E><A><L><S><P><P><R><R><K><A><F><K><K><W><T><P><P><R><S><P><F><N><L><V><Q><E><T><L><F><H><D><P><W><K><L><L><I><A><T><I><F><L><N><R><T><S><G><K><M><A><I><P><V><L><W><K><F><L><E><K><Y><P><S><A><E><V><A><R><T><A><D><W><R><D><V><S><E><L><L><K><P><L><G><L><Y><D><L><R><A><K><T><I><V><K><F><S><D><E><Y><L><T><K><Q><W><K><Y><P><I><E><L><H><G><I><G><K><Y><G><N><D><S><Y><R><I><F><C><V><N><E><W><K><Q><V><H><P><E><D><H><K><L><N><K><Y><H><D><W><L><W><E><N><H><E><K><L><S><L><S>
|
Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.<BOP>
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O95243
|
Q6ZQW0
|
I23O2_HUMAN
|
Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
|
Homo
|
<M><L><H><F><H><Y><Y><D><T><S><N><K><I><M><E><P><H><R><P><N><V><K><T><A><V><P><L><S><L><E><S><Y><H><I><S><E><E><Y><G><F><L><L><P><D><S><L><K><E><L><P><D><H><Y><R><P><W><M><E><I><A><N><K><L><P><Q><L><I><D><A><H><Q><L><Q><A><H><V><D><K><M><P><L><L><S><C><Q><F><L><K><G><H><R><E><Q><R><L><A><H><L><V><L><S><F><L><T><M><G><Y><V><W><Q><E><G><E><A><Q><P><A><E><V><L><P><R><N><L><A><L><P><F><V><E><V><S><R><N><L><G><L><P><P><I><L><V><H><S><D><L><V><L><T><N><W><T><K><K><D><P><D><G><F><L><E><I><G><N><L><E><T><I><I><S><F><P><G><G><E><S><L><H><G><F><I><L><V><T><A><L><V><E><K><E><A><V><P><G><I><K><A><L><V><Q><A><T><N><A><I><L><Q><P><N><Q><E><A><L><L><Q><A><L><Q><R><L><R><L><S><I><Q><D><I><T><K><T><L><G><Q><M><H><D><Y><V><D><P><D><I><F><Y><A><G><I><R><I><F><L><S><G><W><K><D><N><P><A><M><P><A><G><L><M><Y><E><G><V><S><Q><E><P><L><K><Y><S><G><G><S><A><A><Q><S><T><V><L><H><A><F><D><E><F><L><G><I><R><H><S><K><E><S><G><D><F><L><Y><R><M><R><D><Y><M><P><P><S><H><K><A><F><I><E><D><I><H><S><A><P><S><L><R><D><Y><I><L><S><S><G><Q><D><H><L><L><T><A><Y><N><Q><C><V><Q><A><L><A><E><L><R><S><Y><H><I><T><M><V><T><K><Y><L><I><T><A><A><A><K><A><K><H><G><K><P><N><H><L><P><G><P><P><Q><A><L><K><D><R><G><T><G><G><T><A><V><M><S><F><L><K><S><V><R><D><K><T><L><E><S><I><L><H><P><R><G>
|
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway . Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance .<BOP>
|
Q6ZQW0
|
Q7Z4K8
|
TRI46_HUMAN
|
Tripartite, fibronectin type-III and C-terminal SPRY motif protein
|
Homo
|
<M><A><E><G><E><D><M><Q><T><F><T><S><I><M><D><A><L><V><R><I><S><T><S><M><K><N><M><E><K><E><L><L><C><P><V><C><Q><E><M><Y><K><Q><P><L><V><L><P><C><T><H><N><V><C><Q><A><C><A><R><E><V><L><G><Q><Q><G><Y><I><G><H><G><G><D><P><S><S><E><P><T><S><P><A><S><T><P><S><T><R><S><P><R><L><S><R><R><T><L><P><K><P><D><R><L><D><R><L><L><K><S><G><F><G><T><Y><P><G><R><K><R><G><A><L><H><P><Q><V><I><M><F><P><C><P><A><C><Q><G><D><V><E><L><G><E><R><G><L><A><G><L><F><R><N><L><T><L><E><R><V><V><E><R><Y><R><Q><S><V><S><V><G><G><A><I><L><C><Q><L><C><K><P><P><P><L><E><A><T><K><G><C><T><E><C><R><A><T><F><C><N><E><C><F><K><L><F><H><P><W><G><T><Q><K><A><Q><H><E><P><T><L><P><T><L><S><F><R><P><K><G><L><M><C><P><D><H><K><E><E><V><T><H><Y><C><K><T><C><Q><R><L><V><C><Q><L><C><R><V><R><R><T><H><S><G><H><K><I><T><P><V><L><S><A><Y><Q><A><L><K><D><K><L><T><K><S><L><T><Y><I><L><G><N><Q><D><T><V><Q><T><Q><I><C><E><L><E><E><A><V><R><H><T><E><V><S><G><Q><Q><A><K><E><E><V><S><Q><L><V><R><G><L><G><A><V><L><E><E><K><R><A><S><L><L><Q><A><I><E><E><C><Q><Q><E><R><L><A><R><L><S><A><Q><I><Q><E><H><R><S><L><L><D><G><S><G><L><V><G><Y><A><Q><E><V><L><K><E><T><D><Q><P><C><F><V><Q><A><A><K><Q><L><H><N><R><I><A><R><A><T><E><A><L><Q><T><F><R><P><A><A><S><S><S><F><R><H><C><Q><L><D><V><G><R><E><M><K><L><L><T><E><L><N><F><L><R><V><P><E><A><P><V><I><D><T><Q><R><T><F><A><Y><D><Q><I><F><L><C><W><R><L><P><P><H><S><P><P><A><W><H><Y><T><V><E><F><R><R><T><D><V><P><A><Q><P><G><P><T><R><W><Q><R><R><E><E><V><R><G><T><S><A><L><L><E><N><P><D><T><G><S><V><Y><V><L><R><V><R><G><C><N><K><A><G><Y><G><E><Y><S><E><D><V><H><L><H><T><P><P><A><P><V><L><H><F><F><L><D><S><R><W><G><A><S><R><E><R><L><A><I><S><K><D><Q><R><A><V><R><S><V><P><G><L><P><L><L><L><A><A><D><R><L><L><T><G><C><H><L><S><V><D><V><V><L><G><D><V><A><V><T><Q><G><R><S><Y><W><A><C><A><V><D><P><A><S><Y><L><V><K><V><G><V><G><L><E><S><K><L><Q><E><S><F><Q><G><A><P><D><V><I><S><P><R><Y><D><P><D><S><G><H><D><S><G><A><E><D><A><T><V><E><A><S><P><P><F><A><F><L><T><I><G><M><G><K><I><L><L><G><S><G><A><S><S><N><A><G><L><T><G><R><D><G><P><T><A><G><C><T><V><P><L><P><P><R><L><G><I><C><L><D><Y><E><R><G><R><V><S><F><L><D><A><V><S><F><R><G><L><L><E><C><P><L><D><C><S><G><P><V><C><P><A><F><C><F><I><G><G><G><A><V><Q><L><Q><E><P><V><G><T><K><P><E><R><K><V><T><I><G><G><F><A><K><L><D>
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Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.<BOP>
|
Q7Z4K8
|
Q9BY44
|
EIF2A_HUMAN
|
Eukaryotic translation initiation factor 2A, N-terminally processed
|
Homo
|
<M><A><P><S><T><P><L><L><T><V><R><G><S><E><G><L><Y><M><V><N><G><P><P><H><F><T><E><S><T><V><F><P><R><E><S><G><K><N><C><K><V><C><I><F><S><K><D><G><T><L><F><A><W><G><N><G><E><K><V><N><I><I><S><V><T><N><K><G><L><L><H><S><F><D><L><L><K><A><V><C><L><E><F><S><P><K><N><T><V><L><A><T><W><Q><P><Y><T><T><S><K><D><G><T><A><G><I><P><N><L><Q><L><Y><D><V><K><T><G><T><C><L><K><S><F><I><Q><K><K><M><Q><N><W><C><P><S><W><S><E><D><E><T><L><C><A><R><N><V><N><N><E><V><H><F><F><E><N><N><N><F><N><T><I><A><N><K><L><H><L><Q><K><I><N><D><F><V><L><S><P><G><P><Q><P><Y><K><V><A><V><Y><V><P><G><S><K><G><A><P><S><F><V><R><L><Y><Q><Y><P><N><F><A><G><P><H><A><A><L><A><N><K><S><F><F><K><A><D><K><V><T><M><L><W><N><K><K><A><T><A><V><L><V><I><A><S><T><D><V><D><K><T><G><A><S><Y><Y><G><E><Q><T><L><H><Y><I><A><T><N><G><E><S><A><V><V><Q><L><P><K><N><G><P><I><Y><D><V><V><W><N><S><S><S><T><E><F><C><A><V><Y><G><F><M><P><A><K><A><T><I><F><N><L><K><C><D><P><V><F><D><F><G><T><G><P><R><N><A><A><Y><Y><S><P><H><G><H><I><L><V><L><A><G><F><G><N><L><R><G><Q><M><E><V><W><D><V><K><N><Y><K><L><I><S><K><P><V><A><S><D><S><T><Y><F><A><W><C><P><D><G><E><H><I><L><T><A><T><C><A><P><R><L><R><V><N><N><G><Y><K><I><W><H><Y><T><G><S><I><L><H><K><Y><D><V><P><S><N><A><E><L><W><Q><V><S><W><Q><P><F><L><D><G><I><F><P><A><K><T><I><T><Y><Q><A><V><P><S><E><V><P><N><E><E><P><K><V><A><T><A><Y><R><P><P><A><L><R><N><K><P><I><T><N><S><K><L><H><E><E><E><P><P><Q><N><M><K><P><Q><S><G><N><D><K><P><L><S><K><T><A><L><K><N><Q><R><K><H><E><A><K><K><A><A><K><Q><E><A><R><S><D><K><S><P><D><L><A><P><T><P><A><P><Q><S><T><P><R><N><T><V><S><Q><S><I><S><G><D><P><E><I><D><K><K><I><K><N><L><K><K><K><L><K><A><I><E><Q><L><K><E><Q><A><A><T><G><K><Q><L><E><K><N><Q><L><E><K><I><Q><K><E><T><A><L><L><Q><E><L><E><D><L><E><L><G><I>
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Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.<BOP>
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Q9BY44
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Q96I15
|
SCLY_HUMAN
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Selenocysteine lyase
|
Homo
|
<M><E><A><A><V><A><P><G><R><D><A><P><A><P><A><A><S><Q><P><S><G><C><G><K><H><N><S><P><E><R><K><V><Y><M><D><Y><N><A><T><T><P><L><E><P><E><V><I><Q><A><M><T><K><A><M><W><E><A><W><G><N><P><S><S><P><Y><S><A><G><R><K><A><K><D><I><I><N><A><A><R><E><S><L><A><K><M><I><G><G><K><P><Q><D><I><I><F><T><S><G><G><T><E><S><N><N><L><V><I><H><S><V><V><K><H><F><H><A><N><Q><T><S><K><G><H><T><G><G><H><H><S><P><V><K><G><A><K><P><H><F><I><T><S><S><V><E><H><D><S><I><R><L><P><L><E><H><L><V><E><E><Q><V><A><A><V><T><F><V><P><V><S><K><V><S><G><Q><A><E><V><D><D><I><L><A><A><V><R><P><T><T><R><L><V><T><I><M><L><A><N><N><E><T><G><I><V><M><P><V><P><E><I><S><Q><R><I><K><A><L><N><Q><E><R><V><A><A><G><L><P><P><I><L><V><H><T><D><A><A><Q><A><L><G><K><Q><R><V><D><V><E><D><L><G><V><D><F><L><T><I><V><G><H><K><F><Y><G><P><R><I><G><A><L><Y><I><R><G><L><G><E><F><T><P><L><Y><P><M><L><F><G><G><G><Q><E><R><N><F><R><P><G><T><E><N><T><P><M><I><A><G><L><G><K><A><A><E><L><V><T><Q><N><C><E><A><Y><E><A><H><M><R><D><V><R><D><Y><L><E><E><R><L><E><A><E><F><G><Q><K><R><I><H><L><N><S><Q><F><P><G><T><Q><R><L><P><N><T><C><N><F><S><I><R><G><P><R><L><Q><G><H><V><V><L><A><Q><C><R><V><L><M><A><S><V><G><A><A><C><H><S><D><H><G><D><Q><P><S><P><V><L><L><S><Y><G><V><P><F><D><V><A><R><N><A><L><R><L><S><V><G><R><S><T><T><R><A><E><V><D><L><V><V><Q><D><L><K><Q><A><V><A><Q><L><E><D><Q><A>
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Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.<BOP>
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Q96I15
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P22083
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FUT4_HUMAN
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Galactoside 3-L-fucosyltransferase
|
Homo
|
<M><R><R><L><W><G><A><A><R><K><P><S><G><A><G><W><E><K><E><W><A><E><A><P><Q><E><A><P><G><A><W><S><G><R><L><G><P><G><R><S><G><R><K><G><R><A><V><P><G><W><A><S><W><P><A><H><L><A><L><A><A><R><P><A><R><H><L><G><G><A><G><Q><G><P><R><P><L><H><S><G><T><A><P><F><H><S><R><A><S><G><E><R><Q><R><R><L><E><P><Q><L><Q><H><E><S><R><C><R><S><S><T><P><A><D><A><W><R><A><E><A><A><L><P><V><R><A><M><G><A><P><W><G><S><P><T><A><A><A><G><G><R><R><G><W><R><R><G><R><G><L><P><W><T><V><C><V><L><A><A><A><G><L><T><C><T><A><L><I><T><Y><A><C><W><G><Q><L><P><P><L><P><W><A><S><P><T><P><S><R><P><V><G><V><L><L><W><W><E><P><F><G><G><R><D><S><A><P><R><P><P><P><D><C><R><L><R><F><N><I><S><G><C><R><L><L><T><D><R><A><S><Y><G><E><A><Q><A><V><L><F><H><H><R><D><L><V><K><G><P><P><D><W><P><P><P><W><G><I><Q><A><H><T><A><E><E><V><D><L><R><V><L><D><Y><E><E><A><A><A><A><A><E><A><L><A><T><S><S><P><R><P><P><G><Q><R><W><V><W><M><N><F><E><S><P><S><H><S><P><G><L><R><S><L><A><S><N><L><F><N><W><T><L><S><Y><R><A><D><S><D><V><F><V><P><Y><G><Y><L><Y><P><R><S><H><P><G><D><P><P><S><G><L><A><P><P><L><S><R><K><Q><G><L><V><A><W><V><V><S><H><W><D><E><R><Q><A><R><V><R><Y><Y><H><Q><L><S><Q><H><V><T><V><D><V><F><G><R><G><G><P><G><Q><P><V><P><E><I><G><L><L><H><T><V><A><R><Y><K><F><Y><L><A><F><E><N><S><Q><H><L><D><Y><I><T><E><K><L><W><R><N><A><L><L><A><G><A><V><P><V><V><L><G><P><D><R><A><N><Y><E><R><F><V><P><R><G><A><F><I><H><V><D><D><F><P><S><A><S><S><L><A><S><Y><L><L><F><L><D><R><N><P><A><V><Y><R><R><Y><F><H><W><R><R><S><Y><A><V><H><I><T><S><F><W><D><E><P><W><C><R><V><C><Q><A><V><Q><R><A><G><D><R><P><K><S><I><R><N><L><A><S><W><F><E><R>
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Does not generate Lewis X antigens.<BOP>
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P22083
|
Q9H8W4
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PKHF2_HUMAN
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Zinc finger FYVE domain-containing protein 18
|
Homo
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<M><V><D><R><L><A><N><S><E><A><N><T><R><R><I><S><I><V><E><N><C><F><G><A><A><G><Q><P><L><T><I><P><G><R><V><L><I><G><E><G><V><L><T><K><L><C><R><K><K><P><K><A><R><Q><F><F><L><F><N><D><I><L><V><Y><G><N><I><V><I><Q><K><K><K><Y><N><K><Q><H><I><I><P><L><E><N><V><T><I><D><S><I><K><D><E><G><D><L><R><N><G><W><L><I><K><T><P><T><K><S><F><A><V><Y><A><A><T><A><T><E><K><S><E><W><M><N><H><I><N><K><C><V><T><D><L><L><S><K><S><G><K><T><P><S><N><E><H><A><A><V><W><V><P><D><S><E><A><T><V><C><M><R><C><Q><K><A><K><F><T><P><V><N><R><R><H><H><C><R><K><C><G><F><V><V><C><G><P><C><S><E><K><R><F><L><L><P><S><Q><S><S><K><P><V><R><I><C><D><F><C><Y><D><L><L><S><A><G><D><M><A><T><C><Q><P><A><R><S><D><S><Y><S><Q><S><L><K><S><P><L><N><D><M><S><D><D><D><D><D><D><D><S><S><D>
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May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis .<BOP>
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Q9H8W4
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O14933
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UB2L6_HUMAN
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Ubiquitin-protein ligase L6
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Homo
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<M><M><A><S><M><R><V><V><K><E><L><E><D><L><Q><K><K><P><P><P><Y><L><R><N><L><S><S><D><D><A><N><V><L><V><W><H><A><L><L><L><P><D><Q><P><P><Y><H><L><K><A><F><N><L><R><I><S><F><P><P><E><Y><P><F><K><P><P><M><I><K><F><T><T><K><I><Y><H><P><N><V><D><E><N><G><Q><I><C><L><P><I><I><S><S><E><N><W><K><P><C><T><K><T><C><Q><V><L><E><A><L><N><V><L><V><N><R><P><N><I><R><E><P><L><R><M><D><L><A><D><L><L><T><Q><N><P><E><L><F><R><K><N><A><E><E><F><T><L><R><F><G><V><D><R><P><S>
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Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.<BOP>
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O14933
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O14829
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PPE1_HUMAN
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Serine/threonine-protein phosphatase 7
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Homo
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<M><G><C><S><S><S><S><T><K><T><R><R><S><D><T><S><L><R><A><A><L><I><I><Q><N><W><Y><R><G><Y><K><A><R><L><K><A><R><Q><H><Y><A><L><T><I><F><Q><S><I><E><Y><A><D><E><Q><G><Q><M><Q><L><S><T><F><F><S><F><M><L><E><N><Y><T><H><I><H><K><E><E><L><E><L><R><N><Q><S><L><E><S><E><Q><D><M><R><D><R><W><D><Y><V><D><S><I><D><V><P><D><S><Y><N><G><P><R><L><Q><F><P><L><T><C><T><D><I><D><L><L><L><E><A><F><K><E><Q><Q><I><L><H><A><H><Y><V><L><E><V><L><F><E><T><K><K><V><L><K><Q><M><P><N><F><T><H><I><Q><T><S><P><S><K><E><V><T><I><C><G><D><L><H><G><K><L><D><D><L><F><L><I><F><Y><K><N><G><L><P><S><E><R><N><P><Y><V><F><N><G><D><F><V><D><R><G><K><N><S><I><E><I><L><M><I><L><C><V><S><F><L><V><Y><P><N><D><L><H><L><N><R><G><N><H><E><D><F><M><M><N><L><R><Y><G><F><T><K><E><I><L><H><K><Y><K><L><H><G><K><R><I><L><Q><I><L><E><E><F><Y><A><W><L><P><I><G><T><I><V><D><N><E><I><L><V><I><H><G><G><I><S><E><T><T><D><L><N><L><L><H><R><V><E><R><N><K><M><K><S><V><L><I><P><P><T><E><T><N><R><D><H><D><T><D><S><K><H><N><K><V><G><V><T><F><N><A><H><G><R><I><K><T><N><G><S><P><T><E><H><L><T><E><H><E><W><E><Q><I><I><D><I><L><W><S><D><P><R><G><K><N><G><C><F><P><N><T><C><R><G><G><G><C><Y><F><G><P><D><V><T><S><K><I><L><N><K><Y><Q><L><K><M><L><I><R><S><H><E><C><K><P><E><G><Y><E><I><C><H><D><G><K><V><V><T><I><F><S><A><S><N><Y><Y><E><E><G><S><N><R><G><A><Y><I><K><L><C><S><G><T><T><P><R><F><F><Q><Y><Q><V><T><K><A><T><C><F><Q><P><L><R><Q><R><V><D><T><M><E><N><S><A><I><K><I><L><R><E><R><V><I><S><R><K><S><D><L><T><R><A><F><Q><L><Q><D><H><R><K><S><G><K><L><S><V><S><Q><W><A><F><C><M><E><N><I><L><G><L><N><L><P><W><R><S><L><S><S><N><L><V><N><I><D><Q><N><G><N><V><E><Y><M><S><S><F><Q><N><I><R><I><E><K><P><V><Q><E><A><H><S><T><L><V><E><T><L><Y><R><Y><R><S><D><L><E><I><I><F><N><A><I><D><T><D><H><S><G><L><I><S><V><E><E><F><R><A><M><W><K><L><F><S><S><H><Y><N><V><H><I><D><D><S><Q><V><N><K><L><A><N><I><M><D><L><N><K><D><G><S><I><D><F><N><E><F><L><K><A><F><Y><V><V><H><R><Y><E><D><L><M><K><P><D><V><T><N><L><G>
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May have a role in the recovery or adaptation response of photoreceptors. May have a role in development.<BOP>
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O14829
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A1IGU5
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ARH37_HUMAN
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Rho guanine nucleotide exchange factor 37
|
Homo
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<M><A><K><H><G><A><D><E><P><S><S><R><S><G><S><P><D><R><E><G><R><A><S><E><D><R><S><L><L><H><Q><R><L><A><V><R><E><L><I><D><T><E><V><S><Y><L><H><M><L><Q><L><C><A><S><D><I><R><S><R><L><Q><Q><L><P><Q><G><D><L><D><V><L><F><S><N><I><D><D><I><I><K><V><N><S><R><F><L><H><D><L><Q><E><T><A><S><K><E><E><E><Q><V><Q><L><V><G><N><I><F><L><E><F><Q><E><E><L><E><Q><V><Y><K><V><Y><C><A><S><Y><D><Q><A><L><L><L><V><D><T><Y><R><K><E><P><E><L><Q><R><H><I><Q><G><I><V><E><A><V><V><P><Q><A><G><S><S><G><L><S><F><L><L><V><I><P><L><Q><R><I><T><R><Y><P><L><L><L><Q><K><I><L><E><N><T><V><P><D><A><S><A><Y><P><V><L><Q><R><A><V><S><A><L><Q><D><V><N><T><N><I><N><E><Y><K><M><R><K><E><V><A><S><K><Y><T><K><V><E><Q><L><T><L><R><E><R><L><A><R><I><N><T><H><T><L><S><K><K><T><T><R><L><S><Q><L><L><K><Q><E><A><G><L><I><P><R><T><E><D><K><E><F><D><D><L><E><E><R><F><Q><W><V><S><L><C><V><T><E><L><K><N><N><V><A><A><Y><L><D><N><L><Q><A><F><L><Y><F><R><P><H><E><Y><N><L><D><I><P><E><G><P><A><V><Q><Y><C><N><L><A><R><D><L><H><L><E><A><F><L><K><F><K><Q><R><L><E><G><L><V><W><Q><P><L><C><S><L><A><K><A><L><L><G><P><Q><N><L><I><K><K><R><L><D><K><L><L><D><F><E><R><V><E><E><K><L><L><E><V><G><S><V><T><Y><Q><E><E><A><A><R><H><T><Y><Q><A><L><N><S><L><L><V><A><E><L><P><Q><F><N><Q><L><V><M><Q><W><L><G><Q><I><M><C><T><F><V><T><L><Q><R><D><L><A><K><Q><V><L><Q><R><A><E><G><S><M><A><Q><L><P><H><H><H><V><P><E><P><A><F><R><K><L><V><E><D><A><L><G><R><T><S><N><Q><L><R><S><F><Q><E><T><F><E><K><V><Q><P><P><P><T><T><Q><P><L><L><P><G><S><E><R><Q><V><Q><A><L><L><S><R><Y><G><P><G><K><L><Y><Q><V><T><S><N><I><S><G><T><G><T><L><D><L><T><L><P><R><G><Q><I><V><A><I><L><Q><N><K><D><T><K><G><N><S><G><R><W><L><V><D><T><G><G><H><R><G><Y><V><P><A><G><K><L><Q><L><Y><H><V><V><P><S><A><E><E><L><R><R><Q><A><G><L><N><K><D><P><R><C><L><T><P><E><P><S><P><A><L><V><P><S><I><P><T><M><N><Q><V><I><A><A><Y><P><F><V><A><R><S><S><H><E><V><S><L><Q><A><G><Q><P><V><T><I><L><E><A><Q><D><K><K><G><N><P><E><W><S><L><V><E><V><N><G><Q><R><G><Y><V><P><S><G><F><L><A><R><A><R><S><P><V><L><W><G><W><S><L><P><S>
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May act as a guanine nucleotide exchange factor (GEF).<BOP>
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A1IGU5
|
Q9Y2C5
|
S17A4_HUMAN
|
Solute carrier family 17 member 4
|
Homo
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<M><S><T><G><P><D><V><K><A><T><V><G><D><I><S><S><D><G><N><L><N><V><A><Q><E><E><C><S><R><K><G><F><C><S><V><R><H><G><L><A><L><I><L><Q><L><C><N><F><S><I><Y><T><Q><Q><M><N><L><S><I><A><I><P><A><M><V><N><N><T><A><P><P><S><Q><P><N><A><S><T><E><R><P><S><T><D><S><Q><G><Y><W><N><E><T><L><K><E><F><K><A><M><A><P><A><Y><D><W><S><P><E><I><Q><G><I><I><L><S><S><L><N><Y><G><S><F><L><A><P><I><P><S><G><Y><V><A><G><I><F><G><A><K><Y><V><V><G><A><G><L><F><I><S><S><F><L><T><L><F><I><P><L><A><A><N><A><G><V><A><L><L><I><V><L><R><I><V><Q><G><I><A><Q><V><M><V><L><T><G><Q><Y><S><I><W><V><K><W><A><P><P><L><E><R><S><Q><L><T><T><I><A><G><S><G><S><M><L><G><S><F><I><V><L><L><A><G><G><L><L><C><Q><T><I><G><W><P><Y><V><F><Y><I><F><G><G><I><G><C><A><C><C><P><L><W><F><P><L><I><Y><D><D><P><V><N><H><P><F><I><S><A><G><E><K><R><Y><I><V><C><S><L><A><Q><Q><D><C><S><P><G><W><S><L><P><I><R><A><M><I><K><S><L><P><L><W><A><I><L><V><S><Y><F><C><E><Y><W><L><F><Y><T><I><M><A><Y><T><P><T><Y><I><S><S><V><L><Q><A><N><L><R><D><S><G><I><L><S><A><L><P><F><V><V><G><C><I><C><I><I><L><G><G><L><L><A><D><F><L><L><S><R><K><I><L><R><L><I><T><I><R><K><L><F><T><A><I><G><V><L><F><P><S><V><I><L><V><S><L><P><W><V><R><S><S><H><S><M><T><M><T><F><L><V><L><S><S><A><I><S><S><F><C><E><S><G><A><L><V><N><F><L><D><I><A><P><R><Y><T><G><F><L><K><G><L><L><Q><V><F><A><H><I><A><G><A><I><S><P><T><A><A><G><F><F><I><S><Q><D><S><E><F><G><W><R><N><V><F><L><L><S><A><A><V><N><I><S><G><L><V><F><Y><L><I><F><G><R><A><D><V><Q><D><W><A><K><E><Q><T><F><T><H><L>
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Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro).<BOP>
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Q9Y2C5
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A0A075B6I4
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LVX54_HUMAN
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Immunoglobulin lambda variable 10-54
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Homo
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<M><P><W><A><L><L><L><L><T><L><L><T><H><S><A><V><S><V><V><Q><A><G><L><T><Q><P><P><S><V><S><K><G><L><R><Q><T><A><T><L><T><C><T><G><N><S><N><I><V><G><N><Q><G><A><A><W><L><Q><Q><H><Q><G><H><P><P><K><L><L><S><Y><R><N><N><N><R><P><S><G><I><S><E><R><F><S><A><S><R><S><G><N><T><A><S><L><T><I><T><G><L><Q><P><E><D><E><A><D><Y><Y><C><S><A><L><D><S><S><L><S><A>
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V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
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A0A075B6I4
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P23193
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TCEA1_HUMAN
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Transcription elongation factor TFIIS.o
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Homo
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<M><E><D><E><V><V><R><F><A><K><K><M><D><K><M><V><Q><K><K><N><A><A><G><A><L><D><L><L><K><E><L><K><N><I><P><M><T><L><E><L><L><Q><S><T><R><I><G><M><S><V><N><A><I><R><K><Q><S><T><D><E><E><V><T><S><L><A><K><S><L><I><K><S><W><K><K><L><L><D><G><P><S><T><E><K><D><L><D><E><K><K><K><E><P><A><I><T><S><Q><N><S><P><E><A><R><E><E><S><T><S><S><G><N><V><S><N><R><K><D><E><T><N><A><R><D><T><Y><V><S><S><F><P><R><A><P><S><T><S><D><S><V><R><L><K><C><R><E><M><L><A><A><A><L><R><T><G><D><D><Y><I><A><I><G><A><D><E><E><E><L><G><S><Q><I><E><E><A><I><Y><Q><E><I><R><N><T><D><M><K><Y><K><N><R><V><R><S><R><I><S><N><L><K><D><A><K><N><P><N><L><R><K><N><V><L><C><G><N><I><P><P><D><L><F><A><R><M><T><A><E><E><M><A><S><D><E><L><K><E><M><R><K><N><L><T><K><E><A><I><R><E><H><Q><M><A><K><T><G><G><T><Q><T><D><L><F><T><C><G><K><C><K><K><K><N><C><T><Y><T><Q><V><Q><T><R><S><A><D><E><P><M><T><T><F><V><V><C><N><E><C><G><N><R><W><K><F><C>
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Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.<BOP>
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P23193
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Q14626
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I11RA_HUMAN
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Soluble interleukin-11 receptor subunit alpha
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Homo
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<M><S><S><S><C><S><G><L><S><R><V><L><V><A><V><A><T><A><L><V><S><A><S><S><P><C><P><Q><A><W><G><P><P><G><V><Q><Y><G><Q><P><G><R><S><V><K><L><C><C><P><G><V><T><A><G><D><P><V><S><W><F><R><D><G><E><P><K><L><L><Q><G><P><D><S><G><L><G><H><E><L><V><L><A><Q><A><D><S><T><D><E><G><T><Y><I><C><Q><T><L><D><G><A><L><G><G><T><V><T><L><Q><L><G><Y><P><P><A><R><P><V><V><S><C><Q><A><A><D><Y><E><N><F><S><C><T><W><S><P><S><Q><I><S><G><L><P><T><R><Y><L><T><S><Y><R><K><K><T><V><L><G><A><D><S><Q><R><R><S><P><S><T><G><P><W><P><C><P><Q><D><P><L><G><A><A><R><C><V><V><H><G><A><E><F><W><S><Q><Y><R><I><N><V><T><E><V><N><P><L><G><A><S><T><R><L><L><D><V><S><L><Q><S><I><L><R><P><D><P><P><Q><G><L><R><V><E><S><V><P><G><Y><P><R><R><L><R><A><S><W><T><Y><P><A><S><W><P><C><Q><P><H><F><L><L><K><F><R><L><Q><Y><R><P><A><Q><H><P><A><W><S><T><V><E><P><A><G><L><E><E><V><I><T><D><A><V><A><G><L><P><H><A><V><R><V><S><A><R><D><F><L><D><A><G><T><W><S><T><W><S><P><E><A><W><G><T><P><S><T><G><T><I><P><K><E><I><P><A><W><G><Q><L><H><T><Q><P><E><V><E><P><Q><V><D><S><P><A><P><P><R><P><S><L><Q><P><H><P><R><L><L><D><H><R><D><S><V><E><Q><V><A><V><L><A><S><L><G><I><L><S><F><L><G><L><V><A><G><A><L><A><L><G><L><W><L><R><L><R><R><G><G><K><D><G><S><P><K><P><G><F><L><A><S><V><I><P><V><D><R><R><P><G><A><P><N><L>
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Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity . The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling .<BOP>
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Q14626
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Q9UM01
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YLAT1_HUMAN
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y(+)L-type amino acid transporter 1
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Homo
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<M><V><D><S><T><E><Y><E><V><A><S><Q><P><E><V><E><T><S><P><L><G><D><G><A><S><P><G><P><E><Q><V><K><L><K><K><E><I><S><L><L><N><G><V><C><L><I><V><G><N><M><I><G><S><G><I><F><V><S><P><K><G><V><L><I><Y><S><A><S><F><G><L><S><L><V><I><W><A><V><G><G><L><F><S><V><F><G><A><L><C><Y><A><E><L><G><T><T><I><K><K><S><G><A><S><Y><A><Y><I><L><E><A><F><G><G><F><L><A><F><I><R><L><W><T><S><L><L><I><I><E><P><T><S><Q><A><I><I><A><I><T><F><A><N><Y><M><V><Q><P><L><F><P><S><C><F><A><P><Y><A><A><S><R><L><L><A><A><A><C><I><C><L><L><T><F><I><N><C><A><Y><V><K><W><G><T><L><V><Q><D><I><F><T><Y><A><K><V><L><A><L><I><A><V><I><V><A><G><I><V><R><L><G><Q><G><A><S><T><H><F><E><N><S><F><E><G><S><S><F><A><V><G><D><I><A><L><A><L><Y><S><A><L><F><S><Y><S><G><W><D><T><L><N><Y><V><T><E><E><I><K><N><P><E><R><N><L><P><L><S><I><G><I><S><M><P><I><V><T><I><I><Y><I><L><T><N><V><A><Y><Y><T><V><L><D><M><R><D><I><L><A><S><D><A><V><A><V><T><F><A><D><Q><I><F><G><I><F><N><W><I><I><P><L><S><V><A><L><S><C><F><G><G><L><N><A><S><I><V><A><A><S><R><L><F><F><V><G><S><R><E><G><H><L><P><D><A><I><C><M><I><H><V><E><R><F><T><P><V><P><S><L><L><F><N><G><I><M><A><L><I><Y><L><C><V><E><D><I><F><Q><L><I><N><Y><Y><S><F><S><Y><W><F><F><V><G><L><S><I><V><G><Q><L><Y><L><R><W><K><E><P><D><R><P><R><P><L><K><L><S><V><F><F><P><I><V><F><C><L><C><T><I><F><L><V><A><V><P><L><Y><S><D><T><I><N><S><L><I><G><I><A><I><A><L><S><G><L><P><F><Y><F><L><I><I><R><V><P><E><H><K><R><P><L><Y><L><R><R><I><V><G><S><A><T><R><Y><L><Q><V><L><C><M><S><V><A><A><E><M><D><L><E><D><G><G><E><M><P><K><Q><R><D><P><K><S><N>
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Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.<BOP>
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Q9UM01
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Q8WY41
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NANO1_HUMAN
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EC_Rep1a
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Homo
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<M><E><A><F><P><W><A><P><R><S><P><R><R><G><R><A><P><P><P><M><A><L><V><P><S><A><R><Y><V><S><A><P><G><P><A><H><P><Q><P><F><S><S><W><N><D><Y><L><G><L><A><T><L><I><T><K><A><V><D><G><E><P><R><F><G><C><A><R><G><G><N><G><G><G><G><S><P><P><S><S><S><S><S><S><C><C><S><P><H><T><G><A><G><P><G><A><L><G><P><A><L><G><P><P><D><Y><D><E><D><D><D><D><D><S><D><E><P><G><S><R><G><R><Y><L><G><S><A><L><E><L><R><A><L><E><L><C><A><G><P><A><E><A><G><L><L><E><E><R><F><A><E><L><S><P><F><A><G><R><A><A><A><V><L><L><G><C><A><P><A><A><A><A><A><A><T><T><T><S><E><A><T><P><R><E><E><R><A><P><A><W><A><A><E><P><R><L><H><A><A><S><G><A><A><A><A><R><L><L><K><P><E><L><Q><V><C><V><F><C><R><N><N><K><E><A><M><A><L><Y><T><T><H><I><L><K><G><P><D><G><R><V><L><C><P><V><L><R><R><Y><T><C><P><L><C><G><A><S><G><D><N><A><H><T><I><K><Y><C><P><L><S><K><V><P><P><P><P><A><R><P><P><P><R><S><A><R><D><G><P><P><G><K><K><L><R>
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May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.<BOP>
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Q8WY41
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Q13765
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NACA_HUMAN
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Alpha-NAC
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Homo
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<M><P><G><E><A><T><E><T><V><P><A><T><E><Q><E><L><P><Q><P><Q><A><E><T><G><S><G><T><E><S><D><S><D><E><S><V><P><E><L><E><E><Q><D><S><T><Q><A><T><T><Q><Q><A><Q><L><A><A><A><A><E><I><D><E><E><P><V><S><K><A><K><Q><S><R><S><E><K><K><A><R><K><A><M><S><K><L><G><L><R><Q><V><T><G><V><T><R><V><T><I><R><K><S><K><N><I><L><F><V><I><T><K><P><D><V><Y><K><S><P><A><S><D><T><Y><I><V><F><G><E><A><K><I><E><D><L><S><Q><Q><A><Q><L><A><A><A><E><K><F><K><V><Q><G><E><A><V><S><N><I><Q><E><N><T><Q><T><P><T><V><Q><E><E><S><E><E><E><E><V><D><E><T><G><V><E><V><K><D><I><E><L><V><M><S><Q><A><N><V><S><R><A><K><A><V><R><A><L><K><N><N><S><N><D><I><V><N><A><I><M><E><L><T><M>
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Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.<BOP>
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Q13765
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Q5VTQ0
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TT39B_HUMAN
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Tetratricopeptide repeat protein 39B
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Homo
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<M><D><A><V><L><A><C><R><L><R><G><R><G><N><R><V><A><A><L><R><P><R><P><R><P><G><G><S><A><G><P><S><P><F><A><L><L><C><A><G><L><S><P><E><P><R><A><G><V><G><S><E><F><P><A><W><F><L><G><G><S><S><Q><R><R><N><M><A><L><L><G><S><R><A><E><L><E><A><D><E><D><V><F><E><D><A><L><E><T><I><S><I><S><S><H><S><D><M><A><T><S><S><L><H><F><A><S><C><D><T><Q><Q><A><P><R><Q><R><G><A><S><T><V><S><S><S><S><S><T><K><V><D><L><K><S><G><L><E><E><C><A><V><A><L><N><L><F><L><S><N><K><F><T><D><A><L><E><L><L><R><P><W><A><K><E><S><M><Y><H><A><L><G><Y><S><T><I><V><V><L><Q><A><V><L><T><F><E><Q><Q><D><I><Q><N><G><I><S><A><M><K><D><A><L><Q><T><C><Q><K><Y><R><K><K><Y><T><V><V><E><S><F><S><S><L><L><S><R><G><S><L><E><Q><L><S><E><E><E><M><H><A><E><I><C><Y><A><E><C><L><L><Q><K><A><A><L><T><F><V><Q><D><E><N><M><I><N><F><I><K><G><G><L><K><I><R><T><S><Y><Q><I><Y><K><E><C><L><S><I><L><H><E><I><Q><K><N><K><L><Q><Q><E><F><F><Y><E><F><E><G><G><V><K><L><G><S><G><A><F><N><L><M><L><S><L><L><P><A><R><I><I><R><L><L><E><F><I><G><F><S><G><N><R><E><L><G><L><L><Q><L><R><E><G><A><S><G><R><S><M><R><S><A><L><C><C><L><T><I><L><A><F><H><T><Y><I><S><L><I><L><G><T><G><E><V><N><V><A><E><A><E><R><L><L><A><P><F><L><Q><Q><F><P><N><G><S><L><V><L><F><Y><H><A><R><I><E><L><L><K><G><N><L><E><E><A><Q><E><V><F><Q><K><C><I><S><V><Q><E><E><W><K><Q><F><H><H><L><C><Y><W><E><L><M><W><I><N><V><F><Q><Q><N><W><M><Q><A><Y><Y><Y><S><D><L><L><C><K><E><S><K><W><S><K><A><T><Y><V><F><L><K><A><A><I><L><S><M><L><P><E><E><D><V><V><A><T><N><E><N><V><V><T><L><F><R><Q><V><D><S><L><K><Q><R><I><A><G><K><S><I><P><T><E><K><F><A><V><R><K><A><R><R><Y><S><A><S><L><P><A><P><V><K><L><I><L><P><A><L><E><M><M><Y><V><W><N><G><F><S><I><V><S><K><R><K><D><L><S><E><N><L><L><V><T><V><E><K><A><E><A><A><L><Q><S><Q><N><F><N><S><F><S><V><D><D><E><C><L><V><K><L><L><K><G><C><C><L><K><N><L><Q><R><P><L><Q><A><E><L><C><Y><N><H><V><V><E><S><E><K><L><L><K><Y><D><H><Y><L><V><P><F><T><L><F><E><L><A><S><L><Y><K><S><Q><G><E><I><D><K><A><I><K><F><L><E><T><A><R><N><N><Y><K><D><Y><S><L><E><S><R><L><H><F><R><I><Q><A><A><L><H><L><W><R><K><P><S><S><D>
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Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3).<BOP>
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Q5VTQ0
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P20138
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CD33_HUMAN
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gp67
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Homo
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<M><P><L><L><L><L><L><P><L><L><W><A><G><A><L><A><M><D><P><N><F><W><L><Q><V><Q><E><S><V><T><V><Q><E><G><L><C><V><L><V><P><C><T><F><F><H><P><I><P><Y><Y><D><K><N><S><P><V><H><G><Y><W><F><R><E><G><A><I><I><S><R><D><S><P><V><A><T><N><K><L><D><Q><E><V><Q><E><E><T><Q><G><R><F><R><L><L><G><D><P><S><R><N><N><C><S><L><S><I><V><D><A><R><R><R><D><N><G><S><Y><F><F><R><M><E><R><G><S><T><K><Y><S><Y><K><S><P><Q><L><S><V><H><V><T><D><L><T><H><R><P><K><I><L><I><P><G><T><L><E><P><G><H><S><K><N><L><T><C><S><V><S><W><A><C><E><Q><G><T><P><P><I><F><S><W><L><S><A><A><P><T><S><L><G><P><R><T><T><H><S><S><V><L><I><I><T><P><R><P><Q><D><H><G><T><N><L><T><C><Q><V><K><F><A><G><A><G><V><T><T><E><R><T><I><Q><L><N><V><T><Y><V><P><Q><N><P><T><T><G><I><F><P><G><D><G><S><G><K><Q><E><T><R><A><G><V><V><H><G><A><I><G><G><A><G><V><T><A><L><L><A><L><C><L><C><L><I><F><F><I><V><K><T><H><R><R><K><A><A><R><T><A><V><G><R><N><D><T><H><P><T><T><G><S><A><S><P><K><H><Q><K><K><S><K><L><H><G><P><T><E><T><S><S><C><S><G><A><A><P><T><V><E><M><D><E><E><L><H><Y><A><S><L><N><F><H><G><M><N><P><S><K><D><T><S><T><E><Y><S><E><V><R><T><Q>
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Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state . Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans . Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK . These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 . In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules . One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K .<BOP>
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P20138
|
Q9Y653
|
AGRG1_HUMAN
|
GPR56 subunit beta
|
Homo
|
<M><T><P><Q><S><L><L><Q><T><T><L><F><L><L><S><L><L><F><L><V><Q><G><A><H><G><R><G><H><R><E><D><F><R><F><C><S><Q><R><N><Q><T><H><R><S><S><L><H><Y><K><P><T><P><D><L><R><I><S><I><E><N><S><E><E><A><L><T><V><H><A><P><F><P><A><A><H><P><A><S><R><S><F><P><D><P><R><G><L><Y><H><F><C><L><Y><W><N><R><H><A><G><R><L><H><L><L><Y><G><K><R><D><F><L><L><S><D><K><A><S><S><L><L><C><F><Q><H><Q><E><E><S><L><A><Q><G><P><P><L><L><A><T><S><V><T><S><W><W><S><P><Q><N><I><S><L><P><S><A><A><S><F><T><F><S><F><H><S><P><P><H><T><A><A><H><N><A><S><V><D><M><C><E><L><K><R><D><L><Q><L><L><S><Q><F><L><K><H><P><Q><K><A><S><R><R><P><S><A><A><P><A><S><Q><Q><L><Q><S><L><E><S><K><L><T><S><V><R><F><M><G><D><M><V><S><F><E><E><D><R><I><N><A><T><V><W><K><L><Q><P><T><A><G><L><Q><D><L><H><I><H><S><R><Q><E><E><E><Q><S><E><I><M><E><Y><S><V><L><L><P><R><T><L><F><Q><R><T><K><G><R><S><G><E><A><E><K><R><L><L><L><V><D><F><S><S><Q><A><L><F><Q><D><K><N><S><S><Q><V><L><G><E><K><V><L><G><I><V><V><Q><N><T><K><V><A><N><L><T><E><P><V><V><L><T><F><Q><H><Q><L><Q><P><K><N><V><T><L><Q><C><V><F><W><V><E><D><P><T><L><S><S><P><G><H><W><S><S><A><G><C><E><T><V><R><R><E><T><Q><T><S><C><F><C><N><H><L><T><Y><F><A><V><L><M><V><S><S><V><E><V><D><A><V><H><K><H><Y><L><S><L><L><S><Y><V><G><C><V><V><S><A><L><A><C><L><V><T><I><A><A><Y><L><C><S><R><V><P><L><P><C><R><R><K><P><R><D><Y><T><I><K><V><H><M><N><L><L><L><A><V><F><L><L><D><T><S><F><L><L><S><E><P><V><A><L><T><G><S><E><A><G><C><R><A><S><A><I><F><L><H><F><S><L><L><T><C><L><S><W><M><G><L><E><G><Y><N><L><Y><R><L><V><V><E><V><F><G><T><Y><V><P><G><Y><L><L><K><L><S><A><M><G><W><G><F><P><I><F><L><V><T><L><V><A><L><V><D><V><D><N><Y><G><P><I><I><L><A><V><H><R><T><P><E><G><V><I><Y><P><S><M><C><W><I><R><D><S><L><V><S><Y><I><T><N><L><G><L><F><S><L><V><F><L><F><N><M><A><M><L><A><T><M><V><V><Q><I><L><R><L><R><P><H><T><Q><K><W><S><H><V><L><T><L><L><G><L><S><L><V><L><G><L><P><W><A><L><I><F><F><S><F><A><S><G><T><F><Q><L><V><V><L><Y><L><F><S><I><I><T><S><F><Q><G><F><L><I><F><I><W><Y><W><S><M><R><L><Q><A><R><G><G><P><S><P><L><K><S><N><S><D><S><A><R><L><P><I><S><S><G><S><T><S><S><S><R><I>
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Plays a critical role in cancer progression by activating VEGFA production and angiogenesis through a signaling pathway mediated by PRKCA .<BOP>
|
Q9Y653
|
Q96M53
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TBATA_HUMAN
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Thymus, brain and testes-associated protein
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Homo
|
<M><A><T><D><V><Q><L><A><D><Y><P><L><M><S><P><K><A><E><L><K><L><E><K><K><S><G><R><K><P><R><S><P><R><D><S><G><P><Q><K><E><L><V><I><P><G><I><V><D><F><E><R><I><R><R><A><L><R><T><P><K><P><Q><T><P><G><T><Y><C><F><G><R><L><S><H><H><S><F><F><S><R><H><H><P><H><P><Q><H><V><T><H><I><Q><D><L><T><G><K><P><V><C><V><V><R><D><F><P><A><P><L><P><E><S><T><V><F><S><G><C><Q><M><G><I><P><T><I><S><V><P><I><G><D><P><Q><S><N><R><N><P><Q><L><S><S><E><A><W><K><K><E><L><K><E><L><A><S><R><V><A><F><L><T><K><E><D><E><L><K><K><K><E><K><E><Q><K><E><E><P><L><R><E><Q><G><A><K><Y><S><A><E><T><G><R><L><I><P><A><S><T><R><A><V><G><R><R><R><S><H><Q><G><Q><Q><S><Q><S><S><S><R><H><E><G><V><Q><A><F><L><L><Q><D><Q><E><L><L><V><L><E><L><L><C><R><I><L><E><T><D><L><L><S><A><I><Q><F><W><L><L><Y><A><P><P><K><E><K><D><L><A><L><G><L><L><Q><T><A><V><A><Q><L><L><P><Q><P><L><V><S><I><P><T><E><K><L><L><S><Q><L><P><E><V><H><E><P><P><Q><E><K><Q><E><P><P><C><S><Q><S><P><K><K><T><K><I><S><P><F><T><K><S><E><K><P><E><Y><I><G><E><A><Q><V><L><Q><M><H><S><S><Q><N><T><E><K><K><T><S><K><P><R><A><E><S>
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May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function.<BOP>
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Q96M53
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Q6IPT2
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GAR5A_HUMAN
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Golgi-associated RAB2 interactor protein 5A
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Homo
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<M><G><P><P><L><W><P><D><L><Q><E><P><P><P><P><G><T><S><S><Q><I><R><S><P><L><L><C><D><V><I><K><P><A><P><H><H><D><V><T><V><R><V><V><P><P><P><R><F><L><P><L><L><L><R><P><L><P><S><D><G><D><I><A><M><R><R><D><R><G><P><K><P><A><L><G><G><A><G><E><V><E><P><G><G><M><A><A><S><P><T><G><R><P><R><R><L><Q><R><Y><L><Q><S><G><E><F><D><Q><F><R><D><F><P><I><F><E><S><N><F><V><Q><F><C><P><D><I><Y><P><A><P><T><S><D><L><W><P><Q><V><T><R><L><G><E><V><A><N><E><V><T><M><G><V><A><A><S><S><P><A><L><E><L><P><D><L><L><L><L><A><G><P><A><K><E><N><G><H><L><Q><L><F><G><L><F><P><L><K><F><V><Q><L><F><V><H><D><K><S><R><C><Q><L><E><V><K><L><N><T><S><R><T><F><Y><L><Q><L><R><A><P><L><K><T><R><D><R><E><F><G><Q><W><V><R><L><L><Y><R><L><R><F><L><S><A><S><A><V><P><F><T><Q><E>
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RAB2B effector protein which promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis.<BOP>
|
Q6IPT2
|
Q9H410
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DSN1_HUMAN
|
Kinetochore-associated protein DSN1 homolog
|
Homo
|
<M><T><S><V><T><R><S><E><I><I><D><E><K><G><P><V><M><S><K><T><H><D><H><Q><L><E><S><S><L><S><P><V><E><V><F><A><K><T><S><A><S><L><E><M><N><Q><G><V><S><E><E><R><I><H><L><G><S><S><P><K><K><G><G><N><C><D><L><S><H><Q><E><R><L><Q><S><K><S><L><H><L><S><P><Q><E><Q><S><A><S><Y><Q><D><R><R><Q><S><W><R><R><A><S><M><K><E><T><N><R><R><K><S><L><H><P><I><H><Q><G><I><T><E><L><S><R><S><I><S><V><D><L><A><E><S><K><R><L><G><C><L><L><L><S><S><F><Q><F><S><I><Q><K><L><E><P><F><L><R><D><T><K><G><F><S><L><E><S><F><R><A><K><A><S><S><L><S><E><E><L><K><H><F><A><D><G><L><E><T><D><G><T><L><Q><K><C><F><E><D><S><N><G><K><A><S><D><F><S><L><E><A><S><V><A><E><M><K><E><Y><I><T><K><F><S><L><E><R><Q><T><W><D><Q><L><L><L><H><Y><Q><Q><E><A><K><E><I><L><S><R><G><S><T><E><A><K><I><T><E><V><K><V><E><P><M><T><Y><L><G><S><S><Q><N><E><V><L><N><T><K><P><D><Y><Q><K><I><L><Q><N><Q><S><K><V><F><D><C><M><E><L><V><M><D><E><L><Q><G><S><V><K><Q><L><Q><A><F><M><D><E><S><T><Q><C><F><Q><K><V><S><V><Q><L><G><K><R><S><M><Q><Q><L><D><P><S><P><A><R><K><L><L><K><L><Q><L><Q><N><P><P><A><I><H><G><S><G><S><G><S><C><Q>
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Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.<BOP>
|
Q9H410
|
Q13011
|
ECH1_HUMAN
|
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
|
Homo
|
<M><A><A><G><I><V><A><S><R><R><L><R><D><L><L><T><R><R><L><T><G><S><N><Y><P><G><L><S><I><S><L><R><L><T><G><S><S><A><Q><E><E><A><S><G><V><A><L><G><E><A><P><D><H><S><Y><E><S><L><R><V><T><S><A><Q><K><H><V><L><H><V><Q><L><N><R><P><N><K><R><N><A><M><N><K><V><F><W><R><E><M><V><E><C><F><N><K><I><S><R><D><A><D><C><R><A><V><V><I><S><G><A><G><K><M><F><T><A><G><I><D><L><M><D><M><A><S><D><I><L><Q><P><K><G><D><D><V><A><R><I><S><W><Y><L><R><D><I><I><T><R><Y><Q><E><T><F><N><V><I><E><R><C><P><K><P><V><I><A><A><V><H><G><G><C><I><G><G><G><V><D><L><V><T><A><C><D><I><R><Y><C><A><Q><D><A><F><F><Q><V><K><E><V><D><V><G><L><A><A><D><V><G><T><L><Q><R><L><P><K><V><I><G><N><Q><S><L><V><N><E><L><A><F><T><A><R><K><M><M><A><D><E><A><L><G><S><G><L><V><S><R><V><F><P><D><K><E><V><M><L><D><A><A><L><A><L><A><A><E><I><S><S><K><S><P><V><A><V><Q><S><T><K><V><N><L><L><Y><S><R><D><H><S><V><A><E><S><L><N><Y><V><A><S><W><N><M><S><M><L><Q><T><Q><D><L><V><K><S><V><Q><A><T><T><E><N><K><E><L><K><T><V><T><F><S><K><L>
|
Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA.<BOP>
|
Q13011
|
P25101
|
EDNRA_HUMAN
|
Endothelin receptor type A
|
Homo
|
<M><E><T><L><C><L><R><A><S><F><W><L><A><L><V><G><C><V><I><S><D><N><P><E><R><Y><S><T><N><L><S><N><H><V><D><D><F><T><T><F><R><G><T><E><L><S><F><L><V><T><T><H><Q><P><T><N><L><V><L><P><S><N><G><S><M><H><N><Y><C><P><Q><Q><T><K><I><T><S><A><F><K><Y><I><N><T><V><I><S><C><T><I><F><I><V><G><M><V><G><N><A><T><L><L><R><I><I><Y><Q><N><K><C><M><R><N><G><P><N><A><L><I><A><S><L><A><L><G><D><L><I><Y><V><V><I><D><L><P><I><N><V><F><K><L><L><A><G><R><W><P><F><D><H><N><D><F><G><V><F><L><C><K><L><F><P><F><L><Q><K><S><S><V><G><I><T><V><L><N><L><C><A><L><S><V><D><R><Y><R><A><V><A><S><W><S><R><V><Q><G><I><G><I><P><L><V><T><A><I><E><I><V><S><I><W><I><L><S><F><I><L><A><I><P><E><A><I><G><F><V><M><V><P><F><E><Y><R><G><E><Q><H><K><T><C><M><L><N><A><T><S><K><F><M><E><F><Y><Q><D><V><K><D><W><W><L><F><G><F><Y><F><C><M><P><L><V><C><T><A><I><F><Y><T><L><M><T><C><E><M><L><N><R><R><N><G><S><L><R><I><A><L><S><E><H><L><K><Q><R><R><E><V><A><K><T><V><F><C><L><V><V><I><F><A><L><C><W><F><P><L><H><L><S><R><I><L><K><K><T><V><Y><N><E><M><D><K><N><R><C><E><L><L><S><F><L><L><L><M><D><Y><I><G><I><N><L><A><T><M><N><S><C><I><N><P><I><A><L><Y><F><V><S><K><K><F><K><N><C><F><Q><S><C><L><C><C><C><C><Y><Q><S><K><S><L><M><T><S><V><P><M><N><G><T><S><I><Q><W><K><N><H><D><Q><N><N><H><N><T><D><R><S><S><H><K><D><S><M><N>
|
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.<BOP>
|
P25101
|
Q9BTE0
|
NAT9_HUMAN
|
Embryo brain-specific protein
|
Homo
|
<M><R><L><N><Q><N><T><L><L><L><G><K><K><V><V><L><V><P><Y><T><S><E><H><V><P><S><R><Y><H><E><W><M><K><S><E><E><L><Q><R><L><T><A><S><E><P><L><T><L><E><Q><E><Y><A><M><Q><C><S><W><Q><E><D><A><D><K><C><T><F><I><V><L><D><A><E><K><W><Q><A><Q><P><G><A><T><E><E><S><C><M><V><G><D><V><N><L><F><L><T><D><L><E><D><L><T><L><G><E><I><E><V><M><I><A><E><P><S><C><R><G><K><G><L><G><T><E><A><V><L><A><M><L><S><Y><G><V><T><T><L><G><L><T><K><F><E><A><K><I><G><Q><G><N><E><P><S><I><R><M><F><Q><K><L><H><F><E><Q><V><A><T><S><S><V><F><Q><E><V><T><L><R><L><T><V><S><E><S><E><H><Q><W><L><L><E><Q><T><S><H><V><E><E><K><P><Y><R><D><G><S><A><E><P><C>
|
N-acetyltransferase that mediates the acetylation of the N-terminal residues of alpha- and beta-tubulin.<BOP>
|
Q9BTE0
|
Q99676
|
ZN184_HUMAN
|
Zinc finger protein 184
|
Homo
|
<M><E><D><L><S><S><P><D><S><T><L><L><Q><G><G><H><N><L><L><S><S><A><S><F><Q><E><A><V><T><F><K><D><V><I><V><D><F><T><Q><E><E><W><K><Q><L><D><P><G><Q><R><D><L><F><R><D><V><T><L><E><N><Y><T><H><L><V><S><I><G><L><Q><V><S><K><P><D><V><I><S><Q><L><E><Q><G><T><E><P><W><I><M><E><P><S><I><P><V><G><T><C><A><D><W><E><T><R><L><E><N><S><V><S><A><P><E><P><D><I><S><E><E><E><L><S><P><E><V><I><V><E><K><H><K><R><D><D><S><W><S><S><N><L><L><E><S><W><E><Y><E><G><S><L><E><R><Q><Q><A><N><Q><Q><T><L><P><K><E><I><K><V><T><E><K><T><I><P><S><W><E><K><G><P><V><N><N><E><F><G><K><S><V><N><V><S><S><N><L><V><T><Q><E><P><S><P><E><E><T><S><T><K><R><S><I><K><Q><N><S><N><P><V><K><K><E><K><S><C><K><C><N><E><C><G><K><A><F><S><Y><C><S><A><L><I><R><H><Q><R><T><H><T><G><E><K><P><Y><K><C><N><E><C><E><K><A><F><S><R><S><E><N><L><I><N><H><Q><R><I><H><T><G><D><K><P><Y><K><C><D><Q><C><G><K><G><F><I><E><G><P><S><L><T><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><D><E><C><G><K><A><F><S><Q><R><T><H><L><V><Q><H><Q><R><I><H><T><G><E><K><P><Y><T><C><N><E><C><G><K><A><F><S><Q><R><G><H><F><M><E><H><Q><K><I><H><T><G><E><K><P><F><K><C><D><E><C><D><K><T><F><T><R><S><T><H><L><T><Q><H><Q><K><I><H><T><G><E><K><T><Y><K><C><N><E><C><G><K><A><F><N><G><P><S><T><F><I><R><H><H><M><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><S><Q><H><S><N><L><T><Q><H><Q><K><T><H><T><G><E><K><P><Y><D><C><A><E><C><G><K><S><F><S><Y><W><S><S><L><A><Q><H><L><K><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><S><Y><C><S><S><L><T><Q><H><R><R><I><H><T><R><E><K><P><F><E><C><S><E><C><G><K><A><F><S><Y><L><S><N><L><N><Q><H><Q><K><T><H><T><Q><E><K><A><Y><E><C><K><E><C><G><K><A><F><I><R><S><S><S><L><A><K><H><E><R><I><H><T><G><E><K><P><Y><Q><C><H><E><C><G><K><T><F><S><Y><G><S><S><L><I><Q><H><R><K><I><H><T><G><E><R><P><Y><K><C><N><E><C><G><R><A><F><N><Q><N><I><H><L><T><Q><H><K><R><I><H><T><G><A><K><P><Y><E><C><A><E><C><G><K><A><F><R><H><C><S><S><L><A><Q><H><Q><K><T><H><T><E><E><K><P><Y><Q><C><N><K><C><E><K><T><F><S><Q><S><S><H><L><T><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><D><K><A><F><S><R><S><T><H><L><T><E><H><Q><N><T><H><T><G><E><K><P><Y><N><C><N><E><C><R><K><T><F><S><Q><S><T><Y><L><I><Q><H><Q><R><I><H><S><G><E><K><P><F><G><C><N><D><C><G><K><S><F><R><Y><R><S><A><L><N><K><H><Q><R><L><H><P><G><I>
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May be involved in transcriptional regulation.<BOP>
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Q99676
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P54845
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NRL_HUMAN
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Neural retina-specific leucine zipper protein
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Homo
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<M><A><L><P><P><S><P><L><A><M><E><Y><V><N><D><F><D><L><M><K><F><E><V><K><R><E><P><S><E><G><R><P><G><P><P><T><A><S><L><G><S><T><P><Y><S><S><V><P><P><S><P><T><F><S><E><P><G><M><V><G><A><T><E><G><T><R><P><G><L><E><E><L><Y><W><L><A><T><L><Q><Q><Q><L><G><A><G><E><A><L><G><L><S><P><E><E><A><M><E><L><L><Q><G><Q><G><P><V><P><V><D><G><P><H><G><Y><Y><P><G><S><P><E><E><T><G><A><Q><H><V><Q><L><A><E><R><F><S><D><A><A><L><V><S><M><S><V><R><E><L><N><R><Q><L><R><G><C><G><R><D><E><A><L><R><L><K><Q><R><R><R><T><L><K><N><R><G><Y><A><Q><A><C><R><S><K><R><L><Q><Q><R><R><G><L><E><A><E><R><A><R><L><A><A><Q><L><D><A><L><R><A><E><V><A><R><L><A><R><E><R><D><L><Y><K><A><R><C><D><R><L><T><S><S><G><P><G><S><G><D><P><S><H><L><F><L>
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Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B . Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 . Binds in a sequence-specific manner to the rhodopsin promoter .<BOP>
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P54845
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Q2TAA8
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TXIP1_HUMAN
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Translin-associated factor X-interacting protein 1
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Homo
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<M><G><G><H><L><S><P><W><P><T><Y><T><S><G><Q><T><I><L><Q><N><R><K><P><C><S><D><D><Y><R><K><R><V><G><S><C><Q><Q><H><P><F><R><T><A><K><P><Q><Y><L><E><E><L><E><N><Y><L><R><K><E><L><L><L><L><D><L><G><T><D><S><T><Q><E><L><R><L><Q><P><Y><R><E><I><F><E><F><F><I><E><D><F><K><T><Y><K><P><L><L><S><S><I><K><N><A><Y><E><G><M><L><A><H><Q><R><E><K><I><R><A><L><E><P><L><K><A><K><L><V><T><V><N><E><D><C><N><E><R><I><L><A><M><R><A><E><E><K><Y><E><I><S><L><L><K><K><E><K><M><N><L><L><K><L><I><D><K><K><N><E><E><K><I><S><L><Q><S><E><V><T><K><L><R><K><N><L><A><E><E><Y><L><H><Y><L><S><E><R><D><A><C><K><I><L><I><A><D><L><N><E><L><R><Y><Q><R><E><D><M><S><L><A><Q><S><P><G><I><W><G><E><D><P><V><K><L><T><L><A><L><K><M><T><R><Q><D><L><T><R><T><Q><M><E><L><N><N><M><K><A><N><F><G><D><V><V><P><R><R><D><F><E><M><Q><E><K><T><N><K><D><L><Q><E><Q><L><D><T><L><R><A><S><Y><E><E><V><R><K><E><H><E><I><L><M><Q><L><H><M><S><T><L><K><E><R><D><Q><F><F><S><E><L><Q><E><I><Q><R><T><S><T><P><R><P><D><W><T><K><C><K><D><V><V><A><G><G><P><E><R><W><Q><M><L><A><E><G><K><N><S><D><Q><L><V><D><V><L><L><E><E><I><G><S><G><L><L><R><E><K><D><F><F><P><G><L><G><Y><G><E><A><I><P><A><F><L><R><F><D><G><L><V><E><N><K><K><P><S><K><K><D><V><V><N><L><L><K><D><A><W><K><E><R><L><A><E><E><Q><K><E><T><F><P><D><F><F><F><N><F><L><E><H><R><F><G><P><S><D><A><M><A><W><A><Y><T><I><F><E><N><I><K><I><F><H><S><N><E><V><M><S><Q><F><Y><A><V><L><M><G><K><R><S><E><N><V><Y><V><T><Q><K><E><T><V><A><Q><L><L><K><E><M><T><N><A><D><S><Q><N><E><G><L><L><T><M><E><Q><F><N><T><V><L><K><S><T><F><P><L><K><T><E><E><Q><I><Q><E><L><M><E><A><G><G><W><H><P><S><S><S><N><A><D><L><L><N><Y><R><S><L><F><M><E><D><E><E><G><Q><S><E><P><F><V><Q><K><L><W><E><Q><Y><M><D><E><K><D><E><Y><L><Q><Q><L><K><Q><E><L><G><I><E><L><H><E><E><V><T><L><P><K><L><R><G><G><L><M><T><I><D><P><S><L><D><K><Q><T><V><N><T><Y><M><S><Q><A><F><Q><L><P><E><S><E><M><P><E><E><G><D><E><K><E><E><A><V><V><E><I><L><Q><T><A><L><E><R><L><Q><V><I><D><I><R><R><V><G><P><R><E><P><E><P><A><S>
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Possible role in spermatogenesis.<BOP>
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Q2TAA8
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P55084
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ECHB_HUMAN
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Beta-ketothiolase
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Homo
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<M><T><I><L><T><Y><P><F><K><N><L><P><T><A><S><K><W><A><L><R><F><S><I><R><P><L><S><C><S><S><Q><L><R><A><A><P><A><V><Q><T><K><T><K><K><T><L><A><K><P><N><I><R><N><V><V><V><V><D><G><V><R><T><P><F><L><L><S><G><T><S><Y><K><D><L><M><P><H><D><L><A><R><A><A><L><T><G><L><L><H><R><T><S><V><P><K><E><V><V><D><Y><I><I><F><G><T><V><I><Q><E><V><K><T><S><N><V><A><R><E><A><A><L><G><A><G><F><S><D><K><T><P><A><H><T><V><T><M><A><C><I><S><A><N><Q><A><M><T><T><G><V><G><L><I><A><S><G><Q><C><D><V><I><V><A><G><G><V><E><L><M><S><D><V><P><I><R><H><S><R><K><M><R><K><L><M><L><D><L><N><K><A><K><S><M><G><Q><R><L><S><L><I><S><K><F><R><F><N><F><L><A><P><E><L><P><A><V><S><E><F><S><T><S><E><T><M><G><H><S><A><D><R><L><A><A><A><F><A><V><S><R><L><E><Q><D><E><Y><A><L><R><S><H><S><L><A><K><K><A><Q><D><E><G><L><L><S><D><V><V><P><F><K><V><P><G><K><D><T><V><T><K><D><N><G><I><R><P><S><S><L><E><Q><M><A><K><L><K><P><A><F><I><K><P><Y><G><T><V><T><A><A><N><S><S><F><L><T><D><G><A><S><A><M><L><I><M><A><E><E><K><A><L><A><M><G><Y><K><P><K><A><Y><L><R><D><F><M><Y><V><S><Q><D><P><K><D><Q><L><L><L><G><P><T><Y><A><T><P><K><V><L><E><K><A><G><L><T><M><N><D><I><D><A><F><E><F><H><E><A><F><S><G><Q><I><L><A><N><F><K><A><M><D><S><D><W><F><A><E><N><Y><M><G><R><K><T><K><V><G><L><P><P><L><E><K><F><N><N><W><G><G><S><L><S><L><G><H><P><F><G><A><T><G><C><R><L><V><M><A><A><A><N><R><L><R><K><E><G><G><Q><Y><G><L><V><A><A><C><A><A><G><G><Q><G><H><A><M><I><V><E><A><Y><P><K>
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Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway . The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA . Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids . Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity .<BOP>
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P55084
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P21266
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GSTM3_HUMAN
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GSTM3-3
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Homo
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<M><S><C><E><S><S><M><V><L><G><Y><W><D><I><R><G><L><A><H><A><I><R><L><L><L><E><F><T><D><T><S><Y><E><E><K><R><Y><T><C><G><E><A><P><D><Y><D><R><S><Q><W><L><D><V><K><F><K><L><D><L><D><F><P><N><L><P><Y><L><L><D><G><K><N><K><I><T><Q><S><N><A><I><L><R><Y><I><A><R><K><H><N><M><C><G><E><T><E><E><E><K><I><R><V><D><I><I><E><N><Q><V><M><D><F><R><T><Q><L><I><R><L><C><Y><S><S><D><H><E><K><L><K><P><Q><Y><L><E><E><L><P><G><Q><L><K><Q><F><S><M><F><L><G><K><F><S><W><F><A><G><E><K><L><T><F><V><D><F><L><T><Y><D><I><L><D><Q><N><R><I><F><D><P><K><C><L><D><E><F><P><N><L><K><A><F><M><C><R><F><E><A><L><E><K><I><A><A><Y><L><Q><S><D><Q><F><C><K><M><P><I><N><N><K><M><A><Q><W><G><N><K><P><V><C>
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Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.<BOP>
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P21266
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Q68D91
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MBLC2_HUMAN
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Palmitoyl-coenzyme A thioesterase MBLAC2
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Homo
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<M><S><A><L><E><W><Y><A><H><K><S><L><G><D><G><I><F><W><I><Q><E><R><F><Y><E><S><G><N><R><A><N><I><W><L><V><R><G><S><E><Q><D><V><V><I><D><T><G><L><G><L><R><S><L><P><E><Y><L><Y><S><S><G><L><L><Q><D><R><E><A><K><E><D><A><A><R><R><P><L><L><A><V><A><T><H><V><H><F><D><H><S><G><G><L><Y><Q><F><D><R><V><A><V><H><H><A><E><A><E><A><L><A><R><G><D><N><F><E><T><V><T><W><L><S><D><S><E><V><V><R><T><P><S><P><G><W><R><A><R><Q><F><R><V><Q><A><V><Q><P><T><L><I><L><Q><D><G><D><V><I><N><L><G><D><R><Q><L><T><V><M><H><M><P><G><H><S><R><G><S><I><C><L><H><D><K><D><R><K><I><L><F><S><G><D><V><V><Y><D><G><S><L><I><D><W><L><P><Y><S><R><I><S><D><Y><V><G><T><C><E><R><L><I><E><L><V><D><R><G><L><V><E><K><V><L><P><G><H><F><N><T><F><G><A><E><R><L><F><R><L><A><S><N><Y><I><S><K><A><G><I><C><H><K><V><S><T><F><A><M><R><S><L><A><S><L><A><L><R><V><T><N><S><R><T><S><P>
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Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH . Has an acyl-CoA thioesterase activity towards the long chain fatty acyl-CoA thioester palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) . Displays a substrate preference for fatty acyl-CoAs with chain-lengths C12-C18 . Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin . Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) .<BOP>
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Q68D91
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P53778
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MK12_HUMAN
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Stress-activated protein kinase 3
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Homo
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<M><S><S><P><P><P><A><R><S><G><F><Y><R><Q><E><V><T><K><T><A><W><E><V><R><A><V><Y><R><D><L><Q><P><V><G><S><G><A><Y><G><A><V><C><S><A><V><D><G><R><T><G><A><K><V><A><I><K><K><L><Y><R><P><F><Q><S><E><L><F><A><K><R><A><Y><R><E><L><R><L><L><K><H><M><R><H><E><N><V><I><G><L><L><D><V><F><T><P><D><E><T><L><D><D><F><T><D><F><Y><L><V><M><P><F><M><G><T><D><L><G><K><L><M><K><H><E><K><L><G><E><D><R><I><Q><F><L><V><Y><Q><M><L><K><G><L><R><Y><I><H><A><A><G><I><I><H><R><D><L><K><P><G><N><L><A><V><N><E><D><C><E><L><K><I><L><D><F><G><L><A><R><Q><A><D><S><E><M><T><G><Y><V><V><T><R><W><Y><R><A><P><E><V><I><L><N><W><M><R><Y><T><Q><T><V><D><I><W><S><V><G><C><I><M><A><E><M><I><T><G><K><T><L><F><K><G><S><D><H><L><D><Q><L><K><E><I><M><K><V><T><G><T><P><P><A><E><F><V><Q><R><L><Q><S><D><E><A><K><N><Y><M><K><G><L><P><E><L><E><K><K><D><F><A><S><I><L><T><N><A><S><P><L><A><V><N><L><L><E><K><M><L><V><L><D><A><E><Q><R><V><T><A><G><E><A><L><A><H><P><Y><F><E><S><L><H><D><T><E><D><E><P><Q><V><Q><K><Y><D><D><S><F><D><D><V><D><R><T><L><D><E><W><K><R><V><T><Y><K><E><V><L><S><F><K><P><P><R><Q><L><G><A><R><V><S><K><E><T><P><L>
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Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to os
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P53778
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Q5SWA1
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PR15B_HUMAN
| null |
Homo
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<M><E><P><G><T><G><G><S><R><K><R><L><G><P><R><A><G><F><R><F><W><P><P><F><F><P><R><R><S><Q><A><G><S><S><K><F><P><T><P><L><G><P><E><N><S><G><N><P><T><L><L><S><S><A><Q><P><E><T><R><V><S><Y><W><T><K><L><L><S><Q><L><L><A><P><L><P><G><L><L><Q><K><V><L><I><W><S><Q><L><F><G><G><M><F><P><T><R><W><L><D><F><A><G><V><Y><S><A><L><R><A><L><K><G><R><E><K><P><A><A><P><T><A><Q><K><S><L><S><S><L><Q><L><D><S><S><D><P><S><V><T><S><P><L><D><W><L><E><E><G><I><H><W><Q><Y><S><P><P><D><L><K><L><E><L><K><A><K><G><S><A><L><D><P><A><A><Q><A><F><L><L><E><Q><Q><L><W><G><V><E><L><L><P><S><S><L><Q><S><R><L><Y><S><N><R><E><L><G><S><S><P><S><G><P><L><N><I><Q><R><I><D><N><F><S><V><V><S><Y><L><L><N><P><S><Y><L><D><C><F><P><R><L><E><V><S><Y><Q><N><S><D><G><N><S><E><V><V><G><F><Q><T><L><T><P><E><S><S><C><L><R><E><D><H><C><H><P><Q><P><L><S><A><E><L><I><P><A><S><W><Q><G><C><P><P><L><S><T><E><G><L><P><E><I><H><H><L><R><M><K><R><L><E><F><L><Q><Q><A><N><K><G><Q><D><L><P><T><P><D><Q><D><N><G><Y><H><S><L><E><E><E><H><S><L><L><R><M><D><P><K><H><C><R><D><N><P><T><Q><F><V><P><A><A><G><D><I><P><G><N><T><Q><E><S><T><E><E><K><I><E><L><L><T><T><E><V><P><L><A><L><E><E><E><S><P><S><E><G><C><P><S><S><E><I><P><M><E><K><E><P><G><E><G><R><I><S><V><V><D><Y><S><Y><L><E><G><D><L><P><I><S><A><R><P><A><C><S><N><K><L><I><D><Y><I><L><G><G><A><S><S><D><L><E><T><S><S><D><P><E><G><E><D><W><D><E><E><A><E><D><D><G><F><D><S><D><S><S><L><S><D><S><D><L><E><Q><D><P><E><G><L><H><L><W><N><S><F><C><S><V><D><P><Y><N><P><Q><N><F><T><A><T><I><Q><T><A><A><R><I><V><P><E><E><P><S><D><S><E><K><D><L><S><G><K><S><D><L><E><N><S><S><Q><S><G><S><L><P><E><T><P><E><H><S><S><G><E><E><D><D><W><E><S><S><A><D><E><A><E><S><L><K><L><W><N><S><F><C><N><S><D><D><P><Y><N><P><L><N><F><K><A><P><F><Q><T><S><G><E><N><E><K><G><C><R><D><S><K><T><P><S><E><S><I><V><A><I><S><E><C><H><T><L><L><S><C><K><V><Q><L><L><G><S><Q><E><S><E><C><P><D><S><V><Q><R><D><V><L><S><G><G><R><H><T><H><V><K><R><K><K><V><T><F><L><E><E><V><T><E><Y><Y><I><S><G><D><E><D><R><K><G><P><W><E><E><F><A><R><D><G><C><R><F><Q><K><R><I><Q><E><T><E><D><A><I><G><Y><C><L><T><F><E><H><R><E><R><M><F><N><R><L><Q><G><T><C><F><K><G><L><N><V><L><K><Q><C>
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Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.<BOP>
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Q5SWA1
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Q12905
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ILF2_HUMAN
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Nuclear factor of activated T-cells 45 kDa
|
Homo
|
<M><R><G><D><R><G><R><G><R><G><G><R><F><G><S><R><G><G><P><G><G><G><F><R><P><F><V><P><H><I><P><F><D><F><Y><L><C><E><M><A><F><P><R><V><K><P><A><P><D><E><T><S><F><S><E><A><L><L><K><R><N><Q><D><L><A><P><N><S><A><E><Q><A><S><I><L><S><L><V><T><K><I><N><N><V><I><D><N><L><I><V><A><P><G><T><F><E><V><Q><I><E><E><V><R><Q><V><G><S><Y><K><K><G><T><M><T><T><G><H><N><V><A><D><L><V><V><I><L><K><I><L><P><T><L><E><A><V><A><A><L><G><N><K><V><V><E><S><L><R><A><Q><D><P><S><E><V><L><T><M><L><T><N><E><T><G><F><E><I><S><S><S><D><A><T><V><K><I><L><I><T><T><V><P><P><N><L><R><K><L><D><P><E><L><H><L><D><I><K><V><L><Q><S><A><L><A><A><I><R><H><A><R><W><F><E><E><N><A><S><Q><S><T><V><K><V><L><I><R><L><L><K><D><L><R><I><R><F><P><G><F><E><P><L><T><P><W><I><L><D><L><L><G><H><Y><A><V><M><N><N><P><T><R><Q><P><L><A><L><N><V><A><Y><R><R><C><L><Q><I><L><A><A><G><L><F><L><P><G><S><V><G><I><T><D><P><C><E><S><G><N><F><R><V><H><T><V><M><T><L><E><Q><Q><D><M><V><C><Y><T><A><Q><T><L><V><R><I><L><S><H><G><G><F><R><K><I><L><G><Q><E><G><D><A><S><Y><L><A><S><E><I><S><T><W><D><G><V><I><V><T><P><S><E><K><A><Y><E><K><P><P><E><K><K><E><G><E><E><E><E><E><N><T><E><E><P><P><Q><G><E><E><E><E><S><M><E><T><Q><E>
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(Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3.<BOP>
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Q12905
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P43897
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EFTS_HUMAN
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Elongation factor Ts, mitochondrial
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Homo
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<M><S><L><L><R><S><L><R><V><F><L><V><A><R><T><G><S><Y><P><A><G><S><L><L><R><Q><S><P><Q><P><R><H><T><F><Y><A><G><P><R><L><S><A><S><A><S><S><K><E><L><L><M><K><L><R><R><K><T><G><Y><S><F><V><N><C><K><K><A><L><E><T><C><G><G><D><L><K><Q><A><E><I><W><L><H><K><E><A><Q><K><E><G><W><S><K><A><A><K><L><Q><G><R><K><T><K><E><G><L><I><G><L><L><Q><E><G><N><T><T><V><L><V><E><V><N><C><E><T><D><F><V><S><R><N><L><K><F><Q><L><L><V><Q><Q><V><A><L><G><T><M><M><H><C><Q><T><L><K><D><Q><P><S><A><Y><S><K><G><F><L><N><S><S><E><L><S><G><L><P><A><G><P><D><R><E><G><S><L><K><D><Q><L><A><L><A><I><G><K><L><G><E><N><M><I><L><K><R><A><A><W><V><K><V><P><S><G><F><Y><V><G><S><Y><V><H><G><A><M><Q><S><P><S><L><H><K><L><V><L><G><K><Y><G><A><L><V><I><C><E><T><S><E><Q><K><T><N><L><E><D><V><G><R><R><L><G><Q><H><V><V><G><M><A><P><L><S><V><G><S><L><D><D><E><P><G><G><E><A><E><T><K><M><L><S><Q><P><Y><L><L><D><P><S><I><T><L><G><Q><Y><V><Q><P><Q><G><V><S><V><V><D><F><V><R><F><E><C><G><E><G><E><E><A><A><E><T><E>
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Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.<BOP>
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P43897
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O75123
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ZN623_HUMAN
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Zinc finger protein 623
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Homo
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<M><I><L><L><S><F><V><S><D><S><N><V><G><T><G><E><K><K><V><T><E><A><W><I><S><E><D><E><N><S><H><R><T><T><S><D><R><L><T><V><M><E><L><P><S><P><E><S><E><E><V><H><E><P><R><L><G><E><L><L><G><N><P><E><G><Q><S><L><G><S><S><P><S><Q><D><R><G><C><K><Q><V><T><V><T><H><W><K><I><Q><T><G><E><T><A><Q><V><C><T><K><S><G><R><N><H><I><L><N><S><D><L><L><L><L><Q><R><E><L><I><E><G><E><A><N><P><C><D><I><C><G><K><T><F><T><F><N><S><D><L><V><R><H><R><I><S><H><A><G><E><K><P><Y><T><C><D><Q><C><G><K><G><F><G><Q><S><S><H><L><M><E><H><Q><R><I><H><T><G><E><R><L><Y><V><C><N><V><C><G><K><D><F><I><H><Y><S><G><L><I><E><H><Q><R><V><H><S><G><E><K><P><F><K><C><A><Q><C><G><K><A><F><C><H><S><S><D><L><I><R><H><Q><R><V><H><T><R><E><R><P><F><E><C><K><E><C><G><K><G><F><S><Q><S><S><L><L><I><R><H><Q><R><I><H><T><G><E><R><P><Y><E><C><N><E><C><G><K><S><F><I><R><S><S><S><L><I><R><H><Y><Q><I><H><T><E><V><K><Q><Y><E><C><K><E><C><G><K><A><F><R><H><R><S><D><L><I><E><H><Q><R><I><H><T><G><E><R><P><F><E><C><N><E><C><G><K><A><F><I><R><S><S><K><L><I><Q><H><Q><R><I><H><T><G><E><R><P><Y><V><C><N><E><C><G><K><R><F><S><Q><T><S><N><F><T><Q><H><Q><R><I><H><T><G><E><K><L><Y><E><C><N><E><C><G><K><A><F><F><L><S><S><Y><L><I><R><H><Q><K><I><H><T><G><E><R><V><Y><E><C><K><E><C><G><K><A><F><L><Q><K><A><H><L><T><E><H><Q><K><I><H><S><G><D><R><P><F><E><C><K><D><C><G><K><A><F><I><Q><S><S><K><L><L><L><H><Q><I><I><H><T><G><E><K><P><Y><V><C><S><Y><C><G><K><G><F><I><Q><R><S><N><F><L><Q><H><Q><K><I><H><T><E><E><K><L><Y><E><C><S><Q><Y><G><R><D><F><N><S><T><T><N><V><K><N><N><Q><R><V><H><Q><E><G><L><S><L><S><K><A><P><I><H><L><G><E><R><S><V><D><K><G><E><H><T><G><N><L>
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May be involved in transcriptional regulation.<BOP>
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O75123
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Q15620
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OR8B8_HUMAN
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Olfactory-like receptor JCG8
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Homo
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<M><A><A><E><N><S><S><F><V><T><Q><F><I><L><A><G><L><T><D><Q><P><G><V><Q><I><P><L><F><F><L><F><L><G><F><Y><V><V><T><V><V><G><N><L><G><L><I><T><L><I><R><L><N><S><H><L><H><T><P><M><Y><F><F><L><Y><N><L><S><F><I><D><F><C><Y><S><S><V><I><T><P><K><M><L><M><S><F><V><L><K><K><N><S><I><S><Y><A><G><C><M><T><Q><L><F><F><F><L><F><F><V><V><S><E><S><F><I><L><S><A><M><A><Y><D><R><Y><V><A><I><C><N><P><L><L><Y><M><V><T><M><S><P><Q><V><C><F><L><L><L><L><G><V><Y><G><M><G><F><A><G><A><M><A><H><T><A><C><M><M><G><V><T><F><C><A><N><N><L><V><N><H><Y><M><C><D><I><L><P><L><L><E><C><A><C><T><S><T><Y><V><N><E><L><V><V><F><V><V><V><G><I><D><I><G><V><P><T><V><T><I><F><I><S><Y><A><L><I><L><S><S><I><F><H><I><D><S><T><E><G><R><S><K><A><F><S><T><C><S><S><H><I><I><A><V><S><L><F><F><G><S><G><A><F><M><Y><L><K><P><F><S><L><L><A><M><N><Q><G><K><V><S><S><L><F><Y><T><T><V><V><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><K><V><A><L><K><K><I><L><N><K><N><A><F><S>
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Odorant receptor (Potential). May be involved in taste perception.<BOP>
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Q15620
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Q9Y231
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FUT9_HUMAN
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Galactoside 3-L-fucosyltransferase
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Homo
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<M><T><S><T><S><K><G><I><L><R><P><F><L><I><V><C><I><I><L><G><C><F><M><A><C><L><L><I><Y><I><K><P><T><N><S><W><I><F><S><P><M><E><S><A><S><S><V><L><K><M><K><N><F><F><S><T><K><T><D><Y><F><N><E><T><T><I><L><V><W><V><W><P><F><G><Q><T><F><D><L><T><S><C><Q><A><M><F><N><I><Q><G><C><H><L><T><T><D><R><S><L><Y><N><K><S><H><A><V><L><I><H><H><R><D><I><S><W><D><L><T><N><L><P><Q><Q><A><R><P><P><F><Q><K><W><I><W><M><N><L><E><S><P><T><H><T><P><Q><K><S><G><I><E><H><L><F><N><L><T><L><T><Y><R><R><D><S><D><I><Q><V><P><Y><G><F><L><T><V><S><T><N><P><F><V><F><E><V><P><S><K><E><K><L><V><C><W><V><V><S><N><W><N><P><E><H><A><R><V><K><Y><Y><N><E><L><S><K><S><I><E><I><H><T><Y><G><Q><A><F><G><E><Y><V><N><D><K><N><L><I><P><T><I><S><T><C><K><F><Y><L><S><F><E><N><S><I><H><K><D><Y><I><T><E><K><L><Y><N><A><F><L><A><G><S><V><P><V><V><L><G><P><S><R><E><N><Y><E><N><Y><I><P><A><D><S><F><I><H><V><E><D><Y><N><S><P><S><E><L><A><K><Y><L><K><E><V><D><K><N><N><K><L><Y><L><S><Y><F><N><W><R><K><D><F><T><V><N><L><P><R><F><W><E><S><H><A><C><L><A><C><D><H><V><K><R><H><Q><E><Y><K><S><V><G><N><L><E><K><W><F><W><N>
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Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal lactosamine unit of a glycoprotein or a glycolipid-linked polylactosamine chains through an alpha-1,3 glycosidic linkage and participates in particular to the Lewis x (Lex)/CD15 epitope biosynthesis in neurons which allows cell differentiation, cell adhesion, and initiation of neurite outgrowth . Also fucosylates di-, tri- and tetraantennary N-glycans linked to glycoproteins and the inner lactosamine unit of the alpha2,3-sialylated polylactosamine resulting in sLex (CD15s) epitope synthesis . Furthermore, it is capable of synthesizing Lewis a (Lea), although to a lesser extent than Lex and Lewis y (Ley) and to confer SELE-dependent, but not SELL- and SELP-selectin-dependent, cell rolling and adhesion by enhancing Lex and sLex synthesis . May also fucosylate the internal LacNAc unit of the polylactosamine
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Q9Y231
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Q9NSA1
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FGF21_HUMAN
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Fibroblast growth factor 21
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Homo
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<M><D><S><D><E><T><G><F><E><H><S><G><L><W><V><S><V><L><A><G><L><L><L><G><A><C><Q><A><H><P><I><P><D><S><S><P><L><L><Q><F><G><G><Q><V><R><Q><R><Y><L><Y><T><D><D><A><Q><Q><T><E><A><H><L><E><I><R><E><D><G><T><V><G><G><A><A><D><Q><S><P><E><S><L><L><Q><L><K><A><L><K><P><G><V><I><Q><I><L><G><V><K><T><S><R><F><L><C><Q><R><P><D><G><A><L><Y><G><S><L><H><F><D><P><E><A><C><S><F><R><E><L><L><L><E><D><G><Y><N><V><Y><Q><S><E><A><H><G><L><P><L><H><L><P><G><N><K><S><P><H><R><D><P><A><P><R><G><P><A><R><F><L><P><L><P><G><L><P><P><A><L><P><E><P><P><G><I><L><A><P><Q><P><P><D><V><G><S><S><D><P><L><S><M><V><G><P><S><Q><G><R><S><P><S><Y><A><S>
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Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity.<BOP>
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Q9NSA1
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Q5BJF2
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SGMR2_HUMAN
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Transmembrane protein 97
|
Homo
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<M><G><A><P><A><T><R><R><C><V><E><W><L><L><G><L><Y><F><L><S><H><I><P><I><T><L><F><M><D><L><Q><A><V><L><P><R><E><L><Y><P><V><E><F><R><N><L><L><K><W><Y><A><K><E><F><K><D><P><L><L><Q><E><P><P><A><W><F><K><S><F><L><F><C><E><L><V><F><Q><L><P><F><F><P><I><A><T><Y><A><F><L><K><G><S><C><K><W><I><R><T><P><A><I><I><Y><S><V><H><T><M><T><T><L><I><P><I><L><S><T><F><L><F><E><D><F><S><K><A><S><G><F><K><G><Q><R><P><E><T><L><H><E><R><L><T><L><V><S><V><Y><A><P><Y><L><L><I><P><F><I><L><L><I><F><M><L><R><S><P><Y><Y><K><Y><E><E><K><R><K><K><K>
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Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells . Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation . Under investigation for its potential diagnostic and therapeutic uses . May play a role as a regulator of cellular cholesterol homeostasis . May function as sterol isomerase . May alter the activity of some cytochrome P450 proteins .<BOP>
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Q5BJF2
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A0A0B4J2H0
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HV69D_HUMAN
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Immunoglobulin heavy variable 1-69D
|
Homo
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<M><D><W><T><W><R><F><L><F><V><V><A><A><A><T><G><V><Q><S><Q><V><Q><L><V><Q><S><G><A><E><V><K><K><P><G><S><S><V><K><V><S><C><K><A><S><G><G><T><F><S><S><Y><A><I><S><W><V><R><Q><A><P><G><Q><G><L><E><W><M><G><G><I><I><P><I><F><G><T><A><N><Y><A><Q><K><F><Q><G><R><V><T><I><T><A><D><E><S><T><S><T><A><Y><M><E><L><S><S><L><R><S><E><D><T><A><V><Y><Y><C><A><R>
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V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
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A0A0B4J2H0
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Q99633
|
PRP18_HUMAN
|
PRP18 homolog
|
Homo
|
<M><D><I><L><K><S><E><I><L><R><K><R><Q><L><V><E><D><R><N><L><L><V><E><N><K><K><Y><F><K><R><S><E><L><A><K><K><E><E><E><A><Y><F><E><R><C><G><Y><K><I><Q><P><K><E><E><D><Q><K><P><L><T><S><S><N><P><V><L><E><L><E><L><A><E><E><K><L><P><M><T><L><S><R><Q><E><V><I><R><R><L><R><E><R><G><E><P><I><R><L><F><G><E><T><D><Y><D><A><F><Q><R><L><R><K><I><E><I><L><T><P><E><V><N><K><G><L><R><N><D><L><K><A><A><L><D><K><I><D><Q><Q><Y><L><N><E><I><V><G><G><Q><E><P><G><E><E><D><T><Q><N><D><L><K><V><H><E><E><N><T><T><I><E><E><L><E><A><L><G><E><S><L><G><K><G><D><D><H><K><D><M><D><I><I><T><K><F><L><K><F><L><L><G><V><W><A><K><E><L><N><A><R><E><D><Y><V><K><R><S><V><Q><G><K><L><N><S><A><T><Q><K><Q><T><E><S><Y><L><R><P><L><F><R><K><L><R><K><R><N><L><P><A><D><I><K><E><S><I><T><D><I><I><K><F><M><L><Q><R><E><Y><V><K><A><N><D><A><Y><L><Q><M><A><I><G><N><A><P><W><P><I><G><V><T><M><V><G><I><H><A><R><T><G><R><E><K><I><F><S><K><H><V><A><H><V><L><N><D><E><T><Q><R><K><Y><I><Q><G><L><K><R><L><M><T><I><C><Q><K><H><F><P><T><D><P><S><K><C><V><E><Y><N><A><L>
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Participates in the second step of pre-mRNA splicing.<BOP>
|
Q99633
|
Q9H6K1
|
ILRUN_HUMAN
|
Inflammation and lipid regulator with UBA-like and NBR1-like domains protein
|
Homo
|
<M><E><G><M><D><V><D><L><D><P><E><L><M><Q><K><F><S><C><L><G><T><T><D><K><D><V><L><I><S><E><F><Q><R><L><L><G><F><Q><L><N><P><A><G><C><A><F><F><L><D><M><T><N><W><N><L><Q><A><A><I><G><A><Y><Y><D><F><E><S><P><N><I><S><V><P><S><M><S><F><V><E><D><V><T><I><G><E><G><E><S><I><P><P><D><T><Q><F><V><K><T><W><R><I><Q><N><S><G><A><E><A><W><P><P><G><V><C><L><K><Y><V><G><G><D><Q><F><G><H><V><N><M><V><M><V><R><S><L><E><P><Q><E><I><A><D><V><S><V><Q><M><C><S><P><S><R><A><G><M><Y><Q><G><Q><W><R><M><C><T><A><T><G><L><Y><Y><G><D><V><I><W><V><I><L><S><V><E><V><G><G><L><L><G><V><T><Q><Q><L><S><S><F><E><T><E><F><N><T><Q><P><H><R><K><V><E><G><N><F><N><P><F><A><S><P><Q><K><N><R><Q><S><D><E><N><N><L><K><D><P><G><G><S><E><F><D><S><I><S><K><N><T><W><A><P><A><P><D><T><W><A><P><A><P><D><Q><T><E><Q><D><Q><N><R><L><S><Q><N><S><V><N><L><S><P><S><S><H><A><N><N><L><S><V><V><T><Y><S><K><G><L><H><G><P><Y><P><F><G><Q><S>
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Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF . Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP .<BOP>
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Q9H6K1
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Q96I76
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GPTC3_HUMAN
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G patch domain-containing protein 3
|
Homo
|
<M><A><V><P><G><E><A><E><E><E><A><T><V><Y><L><V><V><S><G><I><P><S><V><L><R><S><A><H><L><R><S><Y><F><S><Q><F><R><E><E><R><G><G><G><F><L><C><F><H><Y><R><H><R><P><E><R><A><P><P><Q><A><A><P><N><S><A><L><I><P><T><D><P><A><A><E><G><Q><L><L><S><Q><T><S><A><T><D><V><R><P><L><S><T><R><D><S><T><P><I><Q><T><R><T><C><C><C><V><I><S><V><R><G><L><A><Q><A><Q><R><L><I><R><M><Y><S><G><R><R><W><L><D><S><H><G><T><W><L><P><G><R><C><L><I><R><R><L><R><L><P><T><E><A><S><G><L><G><S><F><P><F><K><T><R><K><E><L><Q><S><W><K><A><E><N><E><A><F><T><L><A><D><L><K><Q><L><P><E><L><N><P><P><V><L><M><P><R><G><N><V><G><T><P><L><R><V><F><L><E><L><I><R><A><C><R><L><P><P><R><I><I><T><Q><L><Q><L><Q><F><P><K><T><G><S><S><R><R><Y><G><N><V><P><F><E><Y><E><D><S><E><T><V><E><Q><E><E><L><V><Y><T><A><E><G><E><E><I><P><Q><G><T><Y><L><A><D><I><P><A><S><P><C><G><E><P><E><E><E><V><G><K><E><E><E><E><E><S><H><S><D><E><D><D><D><R><G><E><E><W><E><R><H><E><A><L><H><E><D><V><T><G><Q><E><R><T><T><E><Q><L><F><E><E><E><I><E><L><K><W><E><K><G><G><S><G><L><V><F><Y><T><D><A><Q><F><W><Q><E><E><E><G><D><F><D><E><Q><T><A><D><D><W><D><V><D><M><S><V><Y><Y><D><R><D><G><G><D><K><D><A><R><D><S><V><Q><M><R><L><E><Q><R><L><R><D><G><Q><E><D><G><S><V><I><E><R><Q><V><G><T><F><E><R><H><T><K><G><I><G><R><K><V><M><E><R><Q><G><W><A><E><G><Q><G><L><G><C><R><C><S><G><V><P><E><A><L><D><S><D><G><Q><H><P><R><C><K><R><G><L><G><Y><H><G><E><K><L><Q><P><F><G><Q><L><K><R><P><R><R><N><G><L><G><L><I><S><T><I><Y><D><E><P><L><P><Q><D><Q><T><E><S><L><L><R><R><Q><P><P><T><S><M><K><F><R><T><D><M><A><F><V><R><G><S><S><C><A><S><D><S><P><S><L><P><D>
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Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development . Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 .<BOP>
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Q96I76
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A0A0B4J238
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TVA12_HUMAN
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T cell receptor alpha variable 1-2
|
Homo
|
<M><W><G><V><F><L><L><Y><V><S><M><K><M><G><G><T><T><G><Q><N><I><D><Q><P><T><E><M><T><A><T><E><G><A><I><V><Q><I><N><C><T><Y><Q><T><S><G><F><N><G><L><F><W><Y><Q><Q><H><A><G><E><A><P><T><F><L><S><Y><N><V><L><D><G><L><E><E><K><G><R><F><S><S><F><L><S><R><S><K><G><Y><S><Y><L><L><L><K><E><L><Q><M><K><D><S><A><S><Y><L><C><A>
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V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
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A0A0B4J238
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Q9Y287
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ITM2B_HUMAN
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P23 peptide
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Homo
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<M><V><K><V><T><F><N><S><A><L><A><Q><K><E><A><K><K><D><E><P><K><S><G><E><E><A><L><I><I><P><P><D><A><V><A><V><D><C><K><D><P><D><D><V><V><P><V><G><Q><R><R><A><W><C><W><C><M><C><F><G><L><A><F><M><L><A><G><V><I><L><G><G><A><Y><L><Y><K><Y><F><A><L><Q><P><D><D><V><Y><Y><C><G><I><K><Y><I><K><D><D><V><I><L><N><E><P><S><A><D><A><P><A><A><L><Y><Q><T><I><E><E><N><I><K><I><F><E><E><E><E><V><E><F><I><S><V><P><V><P><E><F><A><D><S><D><P><A><N><I><V><H><D><F><N><K><K><L><T><A><Y><L><D><L><N><L><D><K><C><Y><V><I><P><L><N><T><S><I><V><M><P><P><R><N><L><L><E><L><L><I><N><I><K><A><G><T><Y><L><P><Q><S><Y><L><I><H><E><H><M><V><I><T><D><R><I><E><N><I><D><H><L><G><F><F><I><Y><R><L><C><H><D><K><E><T><Y><K><L><Q><R><R><E><T><I><K><G><I><Q><K><R><E><A><S><N><C><F><A><I><R><H><F><E><N><K><F><A><V><E><T><L><I><C><S>
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Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.<BOP>
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Q9Y287
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Q93091
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RNAS6_HUMAN
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Ribonuclease K6
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Homo
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<M><V><L><C><F><P><L><L><L><L><L><L><V><L><W><G><P><V><C><P><L><H><A><W><P><K><R><L><T><K><A><H><W><F><E><I><Q><H><I><Q><P><S><P><L><Q><C><N><R><A><M><S><G><I><N><N><Y><T><Q><H><C><K><H><Q><N><T><F><L><H><D><S><F><Q><N><V><A><A><V><C><D><L><L><S><I><V><C><K><N><R><R><H><N><C><H><Q><S><S><K><P><V><N><M><T><D><C><R><L><T><S><G><K><Y><P><Q><C><R><Y><S><A><A><A><Q><Y><K><F><F><I><V><A><C><D><P><P><Q><K><S><D><P><P><Y><K><L><V><P><V><H><L><D><S><I><L>
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Ribonuclease which shows a preference for the pyrimidines uridine and cytosine . Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli . Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria . Probably contributes to urinary tract sterility . Bactericidal activity is independent of RNase activity .<BOP>
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Q93091
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Q86YQ2
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LATH_HUMAN
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Putative latherin
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Homo
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<M><L><N><V><S><G><L><F><V><L><L><C><G><L><L><V><S><S><S><A><Q><E><V><L><A><G><V><S><S><Q><L><L><N><D><L><T><Q><G><L><L><R><A><D><F><L><P><S><L><Q><T><T><G><L><Q><K><P><L><S><S><A><F><D><G><V><S><G><L><L><D><I><F><G><P><P><L><T><N><E><I><N><T><V><S><I><Q><V><K><N><P><Q><L><L><H><V><S><I><E><S><T><P><Q><R><K><E><A><T><V><Q><V><P><F><T><S><E><L><I><V><Q><L><L><T><M><K><P><F><T><A><N><M><Q><S><D><I><K><V><Q><I><R><L><E><K><N><V><G><G><R><Y><E><L><A><F><G><N><C><R><L><L><P><E><A><I><W><I><Q><T><G><V><Q><L><A><P><A><Q><N><L><L><W><Q><T>
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Major protein in sweat, has surfactant properties.<BOP>
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Q86YQ2
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P29692
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EF1D_HUMAN
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Antigen NY-CO-4
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Homo
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<M><A><T><N><F><L><A><H><E><K><I><W><F><D><K><F><K><Y><D><D><A><E><R><R><F><Y><E><Q><M><N><G><P><V><A><G><A><S><R><Q><E><N><G><A><S><V><I><L><R><D><I><A><R><A><R><E><N><I><Q><K><S><L><A><G><S><S><G><P><G><A><S><S><G><T><S><G><D><H><G><E><L><V><V><R><I><A><S><L><E><V><E><N><Q><S><L><R><G><V><V><Q><E><L><Q><Q><A><I><S><K><L><E><A><R><L><N><V><L><E><K><S><S><P><G><H><R><A><T><A><P><Q><T><Q><H><V><S><P><M><R><Q><V><E><P><P><A><K><K><P><A><T><P><A><E><D><D><E><D><D><D><I><D><L><F><G><S><D><N><E><E><E><D><K><E><A><A><Q><L><R><E><E><R><L><R><Q><Y><A><E><K><K><A><K><K><P><A><L><V><A><K><S><S><I><L><L><D><V><K><P><W><D><D><E><T><D><M><A><Q><L><E><A><C><V><R><S><I><Q><L><D><G><L><V><W><G><A><S><K><L><V><P><V><G><Y><G><I><R><K><L><Q><I><Q><C><V><V><E><D><D><K><V><G><T><D><L><L><E><E><E><I><T><K><F><E><E><H><V><Q><S><V><D><I><A><A><F><N><K><I>
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Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).<BOP>
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P29692
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Q7Z449
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CP2U1_HUMAN
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Long-chain fatty acid omega-monooxygenase
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Homo
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<M><S><S><P><G><P><S><Q><P><P><A><E><D><P><P><W><P><A><R><L><L><R><A><P><L><G><L><L><R><L><D><P><S><G><G><A><L><L><L><C><G><L><V><A><L><L><G><W><S><W><L><R><R><R><R><A><R><G><I><P><P><G><P><T><P><W><P><L><V><G><N><F><G><H><V><L><L><P><P><F><L><R><R><R><S><W><L><S><S><R><T><R><A><A><G><I><D><P><S><V><I><G><P><Q><V><L><L><A><H><L><A><R><V><Y><G><S><I><F><S><F><F><I><G><H><Y><L><V><V><V><L><S><D><F><H><S><V><R><E><A><L><V><Q><Q><A><E><V><F><S><D><R><P><R><V><P><L><I><S><I><V><T><K><E><K><G><V><V><F><A><H><Y><G><P><V><W><R><Q><Q><R><K><F><S><H><S><T><L><R><H><F><G><L><G><K><L><S><L><E><P><K><I><I><E><E><F><K><Y><V><K><A><E><M><Q><K><H><G><E><D><P><F><C><P><F><S><I><I><S><N><A><V><S><N><I><I><C><S><L><C><F><G><Q><R><F><D><Y><T><N><S><E><F><K><K><M><L><G><F><M><S><R><G><L><E><I><C><L><N><S><Q><V><L><L><V><N><I><C><P><W><L><Y><Y><L><P><F><G><P><F><K><E><L><R><Q><I><E><K><D><I><T><S><F><L><K><K><I><I><K><D><H><Q><E><S><L><D><R><E><N><P><Q><D><F><I><D><M><Y><L><L><H><M><E><E><E><R><K><N><N><S><N><S><S><F><D><E><E><Y><L><F><Y><I><I><G><D><L><F><I><A><G><T><D><T><T><T><N><S><L><L><W><C><L><L><Y><M><S><L><N><P><D><V><Q><E><K><V><H><E><E><I><E><R><V><I><G><A><N><R><A><P><S><L><T><D><K><A><Q><M><P><Y><T><E><A><T><I><M><E><V><Q><R><L><T><V><V><V><P><L><A><I><P><H><M><T><S><E><N><T><V><L><Q><G><Y><T><I><P><K><G><T><L><I><L><P><N><L><W><S><V><H><R><D><P><A><I><W><E><K><P><E><D><F><Y><P><N><R><F><L><D><D><Q><G><Q><L><I><K><K><E><T><F><I><P><F><G><I><G><K><R><V><C><M><G><E><Q><L><A><K><M><E><L><F><L><M><F><V><S><L><M><Q><S><F><A><F><A><L><P><E><D><S><K><K><P><L><L><T><G><R><F><G><L><T><L><A><P><H><P><F><N><I><T><I><S><R><R>
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A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes . May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin .<BOP>
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Q7Z449
|
O43193
|
MTLR_HUMAN
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G-protein coupled receptor 38
|
Homo
|
<M><G><S><P><W><N><G><S><D><G><P><E><G><A><R><E><P><P><W><P><A><L><P><P><C><D><E><R><R><C><S><P><F><P><L><G><A><L><V><P><V><T><A><V><C><L><C><L><F><V><V><G><V><S><G><N><V><V><T><V><M><L><I><G><R><Y><R><D><M><R><T><T><T><N><L><Y><L><G><S><M><A><V><S><D><L><L><I><L><L><G><L><P><F><D><L><Y><R><L><W><R><S><R><P><W><V><F><G><P><L><L><C><R><L><S><L><Y><V><G><E><G><C><T><Y><A><T><L><L><H><M><T><A><L><S><V><E><R><Y><L><A><I><C><R><P><L><R><A><R><V><L><V><T><R><R><R><V><R><A><L><I><A><V><L><W><A><V><A><L><L><S><A><G><P><F><L><F><L><V><G><V><E><Q><D><P><G><I><S><V><V><P><G><L><N><G><T><A><R><I><A><S><S><P><L><A><S><S><P><P><L><W><L><S><R><A><P><P><P><S><P><P><S><G><P><E><T><A><E><A><A><A><L><F><S><R><E><C><R><P><S><P><A><Q><L><G><A><L><R><V><M><L><W><V><T><T><A><Y><F><F><L><P><F><L><C><L><S><I><L><Y><G><L><I><G><R><E><L><W><S><S><R><R><P><L><R><G><P><A><A><S><G><R><E><R><G><H><R><Q><T><V><R><V><L><L><V><V><V><L><A><F><I><I><C><W><L><P><F><H><V><G><R><I><I><Y><I><N><T><E><D><S><R><M><M><Y><F><S><Q><Y><F><N><I><V><A><L><Q><L><F><Y><L><S><A><S><I><N><P><I><L><Y><N><L><I><S><K><K><Y><R><A><A><A><F><K><L><L><L><A><R><K><S><R><P><R><G><F><H><R><S><R><D><T><A><G><E><V><A><G><D><T><G><G><D><T><V><G><Y><T><E><T><S><A><N><V><K><T><M><G>
|
Receptor for motilin.<BOP>
|
O43193
|
Q03169
|
TNAP2_HUMAN
|
Primary response gene B94 protein
|
Homo
|
<M><S><E><A><S><S><E><D><L><V><P><P><L><E><A><G><A><A><P><Y><R><E><E><E><E><A><A><K><K><K><K><E><K><K><K><K><S><K><G><L><A><N><V><F><C><V><F><T><K><G><K><K><K><K><G><Q><P><S><S><A><E><P><E><D><A><A><G><S><R><Q><G><L><D><G><P><P><P><T><V><E><E><L><K><A><A><L><E><R><G><Q><L><E><A><A><R><P><L><L><A><L><E><R><E><L><A><A><A><A><A><A><G><G><V><S><E><E><E><L><V><R><R><Q><S><K><V><E><A><L><Y><E><L><L><R><D><Q><V><L><G><V><L><R><R><P><L><E><A><P><P><E><R><L><R><Q><A><L><A><V><V><A><E><Q><E><R><E><D><R><Q><A><A><A><A><G><P><G><T><S><G><L><A><A><T><R><P><R><R><W><L><Q><L><W><R><R><G><V><A><E><A><A><E><E><R><M><G><Q><R><P><A><A><G><A><E><V><P><E><S><V><F><L><H><L><G><R><T><M><K><E><D><L><E><A><V><V><E><R><L><K><P><L><F><P><A><E><F><G><V><V><A><A><Y><A><E><S><Y><H><Q><H><F><A><A><H><L><A><A><V><A><Q><F><E><L><C><E><R><D><T><Y><M><L><L><L><W><V><Q><N><L><Y><P><N><D><I><I><N><S><P><K><L><V><G><E><L><Q><G><M><G><L><G><S><L><L><P><P><R><Q><I><R><L><L><E><A><T><F><L><S><S><E><A><A><N><V><R><E><L><M><D><R><A><L><E><L><E><A><R><R><W><A><E><D><V><P><P><Q><R><L><D><G><H><C><H><S><E><L><A><I><D><I><I><Q><I><T><S><Q><A><Q><A><K><A><E><S><I><T><L><D><L><G><S><Q><I><K><R><V><L><L><V><E><L><P><A><F><L><R><S><Y><Q><R><A><F><N><E><F><L><E><R><G><K><Q><L><T><N><Y><R><A><N><V><I><A><N><I><N><N><C><L><S><F><R><M><S><M><E><Q><N><W><Q><V><P><Q><D><T><L><S><L><L><L><G><P><L><G><E><L><K><S><H><G><F><D><T><L><L><Q><N><L><H><E><D><L><K><P><L><F><K><R><F><T><H><T><R><W><A><A><P><V><E><T><L><E><N><I><I><A><T><V><D><T><R><L><P><E><F><S><E><L><Q><G><C><F><R><E><E><L><M><E><A><L><H><L><H><L><V><K><E><Y><I><I><Q><L><S><K><G><R><L><V><L><K><T><A><E><Q><Q><Q><Q><L><A><G><Y><I><L><A><N><A><D><T><I><Q><H><F><C><T><Q><H><G><S><P><A><T><W><L><Q><P><A><L><P><T><L><A><E><I><I><R><L><Q><D><P><S><A><I><K><I><E><V><A><T><Y><A><T><C><Y><P><D><F><S><K><G><H><L><S><A><I><L><A><I><K><G><N><L><S><N><S><E><V><K><R><I><R><S><I><L><D><V><S><M><G><A><Q><E><P><S><R><P><L><F><S><L><I><K><V><G>
|
May play a role as a mediator of inflammation and angiogenesis.<BOP>
|
Q03169
|
P35504
|
UD15_HUMAN
|
UDP-glucuronosyltransferase 1-E
|
Homo
|
<M><A><T><G><L><Q><V><P><L><P><Q><L><A><T><G><L><L><L><L><L><S><V><Q><P><W><A><E><S><G><K><V><L><V><V><P><T><D><G><S><H><W><L><S><M><R><E><A><L><R><D><L><H><A><R><G><H><Q><V><V><V><L><T><L><E><V><N><M><Y><I><K><E><E><N><F><F><T><L><T><T><Y><A><I><S><W><T><Q><D><E><F><D><R><L><L><L><G><H><T><Q><S><F><F><E><T><E><H><L><L><M><K><F><S><R><R><M><A><I><M><N><N><M><S><L><I><I><H><R><S><C><V><E><L><L><H><N><E><A><L><I><R><H><L><H><A><T><S><F><D><V><V><L><T><D><P><F><H><L><C><A><A><V><L><A><K><Y><L><S><I><P><A><V><F><F><L><R><N><I><P><C><D><L><D><F><K><G><T><Q><C><P><N><P><S><S><Y><I><P><R><L><L><T><T><N><S><D><H><M><T><F><L><Q><R><V><K><N><M><L><Y><P><L><A><L><S><Y><L><C><H><A><V><S><A><P><Y><A><S><L><A><S><E><L><F><Q><R><E><V><S><V><V><D><L><V><S><H><A><S><V><W><L><F><R><G><D><F><V><M><D><Y><P><R><P><I><M><P><N><M><V><F><I><G><G><I><N><C><A><N><G><K><P><L><S><Q><E><F><E><A><Y><I><N><A><S><G><E><H><G><I><V><V><F><S><L><G><S><M><V><S><E><I><P><E><K><K><A><M><A><I><A><D><A><L><G><K><I><P><Q><T><V><L><W><R><Y><T><G><T><R><P><S><N><L><A><N><N><T><I><L><V><K><W><L><P><Q><N><D><L><L><G><H><P><M><T><R><A><F><I><T><H><A><G><S><H><G><V><Y><E><S><I><C><N><G><V><P><M><V><M><M><P><L><F><G><D><Q><M><D><N><A><K><R><M><E><T><K><G><A><G><V><T><L><N><V><L><E><M><T><S><E><D><L><E><N><A><L><K><A><V><I><N><D><K><S><Y><K><E><N><I><M><R><L><S><S><L><H><K><D><R><P><V><E><P><L><D><L><A><V><F><W><V><E><F><V><M><R><H><K><G><A><P><H><L><R><P><A><A><H><D><L><T><W><Y><Q><Y><H><S><L><D><V><I><G><F><L><L><A><V><V><L><T><V><A><F><I><T><F><K><C><C><A><Y><G><Y><R><K><C><L><G><K><K><G><R><V><K><K><A><H><K><S><K><T><H>
|
Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.<BOP>
|
P35504
|
O15266
|
SHOX_HUMAN
|
Short stature homeobox-containing protein
|
Homo
|
<M><E><E><L><T><A><F><V><S><K><S><F><D><Q><K><S><K><D><G><N><G><G><G><G><G><G><G><G><K><K><D><S><I><T><Y><R><E><V><L><E><S><G><L><A><R><S><R><E><L><G><T><S><D><S><S><L><Q><D><I><T><E><G><G><G><H><C><P><V><H><L><F><K><D><H><V><D><N><D><K><E><K><L><K><E><F><G><T><A><R><V><A><E><G><I><Y><E><C><K><E><K><R><E><D><V><K><S><E><D><E><D><G><Q><T><K><L><K><Q><R><R><S><R><T><N><F><T><L><E><Q><L><N><E><L><E><R><L><F><D><E><T><H><Y><P><D><A><F><M><R><E><E><L><S><Q><R><L><G><L><S><E><A><R><V><Q><V><W><F><Q><N><R><R><A><K><C><R><K><Q><E><N><Q><M><H><K><G><V><I><L><G><T><A><N><H><L><D><A><C><R><V><A><P><Y><V><N><M><G><A><L><R><M><P><F><Q><Q><V><Q><A><Q><L><Q><L><E><G><V><A><H><A><H><P><H><L><H><P><H><L><A><A><H><A><P><Y><L><M><F><P><P><P><P><F><G><L><P><I><A><S><L><A><E><S><A><S><A><A><A><V><V><A><A><A><A><K><S><N><S><K><N><S><S><I><A><D><L><R><L><K><A><R><K><H><A><E><A><L><G><L>
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Controls fundamental aspects of growth and development.<BOP>
|
O15266
|
O14931
|
NCTR3_HUMAN
|
Natural killer cell p30-related protein
|
Homo
|
<M><A><W><M><L><L><L><I><L><I><M><V><H><P><G><S><C><A><L><W><V><S><Q><P><P><E><I><R><T><L><E><G><S><S><A><F><L><P><C><S><F><N><A><S><Q><G><R><L><A><I><G><S><V><T><W><F><R><D><E><V><V><P><G><K><E><V><R><N><G><T><P><E><F><R><G><R><L><A><P><L><A><S><S><R><F><L><H><D><H><Q><A><E><L><H><I><R><D><V><R><G><H><D><A><S><I><Y><V><C><R><V><E><V><L><G><L><G><V><G><T><G><N><G><T><R><L><V><V><E><K><E><H><P><Q><L><G><A><G><T><V><L><L><L><R><A><G><F><Y><A><V><S><F><L><S><V><A><V><G><S><T><V><Y><Y><Q><G><K><C><L><T><W><K><G><P><R><R><Q><L><P><A><V><V><P><A><P><L><P><P><P><C><G><S><S><A><H><L><L><P><P><V><P><G><G>
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Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.<BOP>
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O14931
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P42680
|
TEC_HUMAN
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Tyrosine-protein kinase Tec
|
Homo
|
<M><N><F><N><T><I><L><E><E><I><L><I><K><R><S><Q><Q><K><K><K><T><S><P><L><N><Y><K><E><R><L><F><V><L><T><K><S><M><L><T><Y><Y><E><G><R><A><E><K><K><Y><R><K><G><F><I><D><V><S><K><I><K><C><V><E><I><V><K><N><D><D><G><V><I><P><C><Q><N><K><Y><P><F><Q><V><V><H><D><A><N><T><L><Y><I><F><A><P><S><P><Q><S><R><D><L><W><V><K><K><L><K><E><E><I><K><N><N><N><N><I><M><I><K><Y><H><P><K><F><W><T><D><G><S><Y><Q><C><C><R><Q><T><E><K><L><A><P><G><C><E><K><Y><N><L><F><E><S><S><I><R><K><A><L><P><P><A><P><E><T><K><K><R><R><P><P><P><P><I><P><L><E><E><E><D><N><S><E><E><I><V><V><A><M><Y><D><F><Q><A><A><E><G><H><D><L><R><L><E><R><G><Q><E><Y><L><I><L><E><K><N><D><V><H><W><W><R><A><R><D><K><Y><G><N><E><G><Y><I><P><S><N><Y><V><T><G><K><K><S><N><N><L><D><Q><Y><E><W><Y><C><R><N><M><N><R><S><K><A><E><Q><L><L><R><S><E><D><K><E><G><G><F><M><V><R><D><S><S><Q><P><G><L><Y><T><V><S><L><Y><T><K><F><G><G><E><G><S><S><G><F><R><H><Y><H><I><K><E><T><T><T><S><P><K><K><Y><Y><L><A><E><K><H><A><F><G><S><I><P><E><I><I><E><Y><H><K><H><N><A><A><G><L><V><T><R><L><R><Y><P><V><S><V><K><G><K><N><A><P><T><T><A><G><F><S><Y><E><K><W><E><I><N><P><S><E><L><T><F><M><R><E><L><G><S><G><L><F><G><V><V><R><L><G><K><W><R><A><Q><Y><K><V><A><I><K><A><I><R><E><G><A><M><C><E><E><D><F><I><E><E><A><K><V><M><M><K><L><T><H><P><K><L><V><Q><L><Y><G><V><C><T><Q><Q><K><P><I><Y><I><V><T><E><F><M><E><R><G><C><L><L><N><F><L><R><Q><R><Q><G><H><F><S><R><D><V><L><L><S><M><C><Q><D><V><C><E><G><M><E><Y><L><E><R><N><S><F><I><H><R><D><L><A><A><R><N><C><L><V><S><E><A><G><V><V><K><V><S><D><F><G><M><A><R><Y><V><L><D><D><Q><Y><T><S><S><S><G><A><K><F><P><V><K><W><C><P><P><E><V><F><N><Y><S><R><F><S><S><K><S><D><V><W><S><F><G><V><L><M><W><E><V><F><T><E><G><R><M><P><F><E><K><Y><T><N><Y><E><V><V><T><M><V><T><R><G><H><R><L><Y><Q><P><K><L><A><S><N><Y><V><Y><E><V><M><L><R><C><W><Q><E><K><P><E><G><R><P><S><F><E><D><L><L><R><T><I><D><E><L><V><E><C><E><E><T><F><G><R>
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Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB1
|
P42680
|
Q8IWL2
|
SFTA1_HUMAN
|
Collectin-4
|
Homo
|
<M><W><L><C><P><L><A><L><N><L><I><L><M><A><A><S><G><A><V><C><E><V><K><D><V><C><V><G><S><P><G><I><P><G><T><P><G><S><H><G><L><P><G><R><D><G><R><D><G><L><K><G><D><P><G><P><P><G><P><M><G><P><P><G><E><M><P><C><P><P><G><N><D><G><L><P><G><A><P><G><I><P><G><E><C><G><E><K><G><E><P><G><E><R><G><P><P><G><L><P><A><H><L><D><E><E><L><Q><A><T><L><H><D><F><R><H><Q><I><L><Q><T><R><G><A><L><S><L><Q><G><S><I><M><T><V><G><E><K><V><F><S><S><N><G><Q><S><I><T><F><D><A><I><Q><E><A><C><A><R><A><G><G><R><I><A><V><P><R><N><P><E><E><N><E><A><I><A><S><F><V><K><K><Y><N><T><Y><A><Y><V><G><L><T><E><G><P><S><P><G><D><F><R><Y><S><D><G><T><P><V><N><Y><T><N><W><Y><R><G><E><P><A><G><R><G><K><E><Q><C><V><E><M><Y><T><D><G><Q><W><N><D><R><N><C><L><Y><S><R><L><T><I><C><E><F>
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(Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen . When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen .<BOP>
|
Q8IWL2
|
Q9HBT8
|
Z286A_HUMAN
|
Zinc finger protein 286A
|
Homo
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<M><E><T><D><L><A><E><M><P><E><K><G><A><L><S><S><Q><D><S><P><H><F><Q><E><K><S><T><E><E><G><E><V><A><A><L><R><L><T><A><R><S><Q><E><T><V><T><F><K><D><V><A><M><D><F><T><P><E><E><W><G><K><L><D><P><A><Q><R><D><V><M><L><E><N><Y><R><N><L><V><S><L><W><L><P><V><S><K><P><E><S><Y><N><L><E><N><G><K><E><P><L><K><L><E><R><K><A><P><K><S><S><Y><S><D><M><E><T><R><P><Q><S><K><D><S><T><S><V><Q><D><F><S><K><A><E><S><C><K><V><A><I><I><D><R><L><T><R><N><S><V><Y><D><S><N><L><E><A><A><L><E><C><E><N><W><L><E><N><Q><Q><G><N><Q><E><R><H><L><R><E><M><F><T><H><M><N><S><L><S><E><E><T><D><H><K><H><D><V><Y><W><K><S><F><N><Q><K><S><V><L><I><T><E><D><R><V><P><K><G><S><Y><A><F><H><T><L><E><K><S><L><K><Q><K><S><N><L><M><K><K><Q><R><T><Y><K><E><K><K><P><H><K><C><N><D><C><G><E><L><F><T><Y><H><S><V><L><I><R><H><Q><R><V><H><T><G><E><K><P><Y><T><C><N><E><C><G><K><S><F><S><H><R><A><N><L><T><K><H><Q><R><T><H><T><R><I><L><F><E><C><S><E><C><K><K><T><F><T><E><S><S><S><L><A><T><H><Q><R><I><H><V><G><E><R><P><Y><E><C><N><E><C><G><K><G><F><N><R><S><T><H><L><V><Q><H><Q><L><I><H><T><G><V><K><P><Y><E><C><N><E><C><D><K><A><F><I><H><S><S><A><L><I><K><H><Q><R><T><H><T><G><E><K><P><Y><K><C><Q><E><C><G><K><A><F><S><H><C><S><S><L><T><K><H><Q><R><V><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><T><F><S><Q><S><T><H><L><V><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><T><F><S><R><S><S><N><F><A><K><H><Q><R><I><H><I><G><K><K><P><Y><K><C><S><E><C><G><K><A><F><I><H><S><S><A><L><I><Q><H><Q><R><T><H><T><G><E><K><P><F><R><C><N><E><C><G><K><S><F><K><C><S><S><S><L><I><R><H><Q><R><V><H><T><E><E><Q><P>
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May be involved in transcriptional regulation.<BOP>
|
Q9HBT8
|
Q6UWI2
|
PARM1_HUMAN
|
Prostate androgen-regulated mucin-like protein 1
|
Homo
|
<M><V><Y><K><T><L><F><A><L><C><I><L><T><A><G><W><R><V><Q><S><L><P><T><S><A><P><L><S><V><S><L><P><T><N><I><V><P><P><T><T><I><W><T><S><S><P><Q><N><T><D><A><D><T><A><S><P><S><N><G><T><H><N><N><S><V><L><P><V><T><A><S><A><P><T><S><L><L><P><K><N><I><S><I><E><S><R><E><E><E><I><T><S><P><G><S><N><W><E><G><T><N><T><D><P><S><P><S><G><F><S><S><T><S><G><G><V><H><L><T><T><T><L><E><E><H><S><S><G><T><P><E><A><G><V><A><A><T><L><S><Q><S><A><A><E><P><P><T><L><I><S><P><Q><A><P><A><S><S><P><S><S><L><S><T><S><P><P><E><V><F><S><A><S><V><T><T><N><H><S><S><T><V><T><S><T><Q><P><T><G><A><P><T><A><P><E><S><P><T><E><E><S><S><S><D><H><T><P><T><S><H><A><T><A><E><P><V><P><Q><E><K><T><P><P><T><T><V><S><G><K><V><M><C><E><L><I><D><M><E><T><T><T><T><F><P><R><V><I><M><Q><E><V><E><H><A><L><S><S><G><S><I><A><A><I><T><V><T><V><I><A><V><V><L><L><V><F><G><V><A><A><Y><L><K><I><R><H><S><S><Y><G><R><L><L><D><D><H><D><Y><G><S><W><G><N><Y><N><N><P><L><Y><D><D><S>
|
May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis.<BOP>
|
Q6UWI2
|
Q99436
|
PSB7_HUMAN
|
Proteasome subunit Z
|
Homo
|
<M><A><A><V><S><V><Y><A><P><P><V><G><G><F><S><F><D><N><C><R><R><N><A><V><L><E><A><D><F><A><K><R><G><Y><K><L><P><K><V><R><K><T><G><T><T><I><A><G><V><V><Y><K><D><G><I><V><L><G><A><D><T><R><A><T><E><G><M><V><V><A><D><K><N><C><S><K><I><H><F><I><S><P><N><I><Y><C><C><G><A><G><T><A><A><D><T><D><M><T><T><Q><L><I><S><S><N><L><E><L><H><S><L><S><T><G><R><L><P><R><V><V><T><A><N><R><M><L><K><Q><M><L><F><R><Y><Q><G><Y><I><G><A><A><L><V><L><G><G><V><D><V><T><G><P><H><L><Y><S><I><Y><P><H><G><S><T><D><K><L><P><Y><V><T><M><G><S><G><S><L><A><A><M><A><V><F><E><D><K><F><R><P><D><M><E><E><E><E><A><K><N><L><V><S><E><A><I><A><A><G><I><F><N><D><L><G><S><G><S><N><I><D><L><C><V><I><S><K><N><K><L><D><F><L><R><P><Y><T><V><P><N><K><K><G><T><R><L><G><R><Y><R><C><E><K><G><T><T><A><V><L><T><E><K><I><T><P><L><E><I><E><V><L><E><E><T><V><Q><T><M><D><T><S>
|
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.<BOP>
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Q99436
|
Q8IYB1
|
M21D2_HUMAN
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Mab-21 domain-containing protein 2
|
Homo
|
<M><K><M><A><A><P><T><A><N><K><A><A><S><L><G><C><N><N><K><P><A><F><P><E><L><D><F><R><S><G><A><R><V><E><E><L><N><K><L><I><Q><E><F><T><K><H><D><Q><R><E><Y><D><D><Q><R><A><L><E><I><H><T><A><K><D><F><I><F><S><M><L><G><M><V><Q><K><L><D><Q><K><L><P><V><A><N><E><Y><L><L><L><S><G><G><V><R><E><G><V><V><D><L><D><L><D><E><L><N><V><Y><A><R><G><T><D><Y><D><M><D><F><T><L><L><V><P><A><L><K><L><H><D><R><N><Q><P><V><T><L><D><M><R><H><S><A><L><C><H><S><W><L><S><L><R><L><F><D><E><G><T><I><S><K><W><K><D><C><C><T><I><V><D><H><I><N><G><A><T><N><Y><F><F><S><P><T><K><V><A><D><W><F><Y><D><S><I><S><I><V><L><S><E><I><Q><K><K><P><Q><R><G><M><P><K><V><E><K><V><E><K><N><G><T><I><I><S><I><I><L><G><V><G><S><S><R><M><L><Y><D><I><V><P><V><V><S><F><K><G><W><P><A><V><A><Q><S><W><L><M><E><N><H><F><W><D><G><K><I><T><E><E><E><V><I><S><G><F><Y><L><V><P><A><C><S><Y><K><G><K><K><D><N><E><W><R><L><S><F><A><R><S><E><V><Q><L><K><K><C><I><S><S><S><L><M><Q><A><Y><Q><A><C><K><A><I><I><I><K><L><L><S><R><P><K><A><I><S><P><Y><H><L><R><S><M><M><L><W><A><C><D><R><L><P><A><N><Y><L><A><Q><E><D><Y><A><A><H><F><L><L><G><L><I><D><D><L><Q><H><C><L><V><N><K><M><C><P><N><Y><F><I><P><Q><C><N><M><L><E><H><L><S><E><E><T><V><M><L><H><A><R><K><L><S><S><V><R><S><D><P><A><E><H><L><R><T><A><I><E><H><V><K><A><A><N><R><L><T><L><E><L><Q><R><R><G><S><T><T><S><I><P><S><P><Q><S><D><G><G><D><P><N><Q><P><D><D><R><L><A><K><K><L><Q><Q><L><V><T><E><N><P><G><K><S><I><S><V><F><I><N><P><D><D><V><T><R><P><H><F><R><I><D><D><K><F><F>
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Probable nucleotidyltransferase that catalyzes the formation of cyclic dinucleotide second messenger in response to some unknown stimulus.<BOP>
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Q8IYB1
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Q8N0X7
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SPART_HUMAN
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Trans-activated by hepatitis C virus core protein 1
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Homo
|
<M><E><Q><E><P><Q><N><G><E><P><A><E><I><K><I><I><R><E><A><Y><K><K><A><F><L><F><V><N><K><G><L><N><T><D><E><L><G><Q><K><E><E><A><K><N><Y><Y><K><Q><G><I><G><H><L><L><R><G><I><S><I><S><S><K><E><S><E><H><T><G><P><G><W><E><S><A><R><Q><M><Q><Q><K><M><K><E><T><L><Q><N><V><R><T><R><L><E><I><L><E><K><G><L><A><T><S><L><Q><N><D><L><Q><E><V><P><K><L><Y><P><E><F><P><P><K><D><M><C><E><K><L><P><E><P><Q><S><F><S><S><A><P><Q><H><A><E><V><N><G><N><T><S><T><P><S><A><G><A><V><A><A><P><A><S><L><S><L><P><S><Q><S><C><P><A><E><A><P><P><A><Y><T><P><Q><A><A><E><G><H><Y><T><V><S><Y><G><T><D><S><G><E><F><S><S><V><G><E><E><F><Y><R><N><H><S><Q><P><P><P><L><E><T><L><G><L><D><A><D><E><L><I><L><I><P><N><G><V><Q><I><F><F><V><N><P><A><G><E><V><S><A><P><S><Y><P><G><Y><L><R><I><V><R><F><L><D><N><S><L><D><T><V><L><N><R><P><P><G><F><L><Q><V><C><D><W><L><Y><P><L><V><P><D><R><S><P><V><L><K><C><T><A><G><A><Y><M><F><P><D><T><M><L><Q><A><A><G><C><F><V><G><V><V><L><S><S><E><L><P><E><D><D><R><E><L><F><E><D><L><L><R><Q><M><S><D><L><R><L><Q><A><N><W><N><R><A><E><E><E><N><E><F><Q><I><P><G><R><T><R><P><S><S><D><Q><L><K><E><A><S><G><T><D><V><K><Q><L><D><Q><G><N><K><D><V><R><H><K><G><K><R><G><K><R><A><K><D><T><S><S><E><E><V><N><L><S><H><I><V><P><C><E><P><V><P><E><E><K><P><K><E><L><P><E><W><S><E><K><V><A><H><N><I><L><S><G><A><S><W><V><S><W><G><L><V><K><G><A><E><I><T><G><K><A><I><Q><K><G><A><S><K><L><R><E><R><I><Q><P><E><E><K><P><V><E><V><S><P><A><V><T><K><G><L><Y><I><A><K><Q><A><T><G><G><A><A><K><V><S><Q><F><L><V><D><G><V><C><T><V><A><N><C><V><G><K><E><L><A><P><H><V><K><K><H><G><S><K><L><V><P><E><S><L><K><K><D><K><D><G><K><S><P><L><D><G><A><M><V><V><A><A><S><S><V><Q><G><F><S><T><V><W><Q><G><L><E><C><A><A><K><C><I><V><N><N><V><S><A><E><T><V><Q><T><V><R><Y><K><Y><G><Y><N><A><G><E><A><T><H><H><A><V><D><S><A><V><N><V><G><V><T><A><Y><N><I><N><N><I><G><I><K><A><M><V><K><K><T><A><T><Q><T><G><H><T><L><L><E><D><Y><Q><I><V><D><N><S><Q><R><E><N><Q><E><G><A><A><N><V><N><V><R><G><E><K><D><E><Q><T><K><E><V><K><E><A><K><K><K><D><K>
|
May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis .<BOP>
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Q8N0X7
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Q96CA5
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BIRC7_HUMAN
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Baculoviral IAP repeat-containing protein 7 30kDa subunit
|
Homo
|
<M><G><P><K><D><S><A><K><C><L><H><R><G><P><Q><P><S><H><W><A><A><G><D><G><P><T><Q><E><R><C><G><P><R><S><L><G><S><P><V><L><G><L><D><T><C><R><A><W><D><H><V><D><G><Q><I><L><G><Q><L><R><P><L><T><E><E><E><E><E><E><G><A><G><A><T><L><S><R><G><P><A><F><P><G><M><G><S><E><E><L><R><L><A><S><F><Y><D><W><P><L><T><A><E><V><P><P><E><L><L><A><A><A><G><F><F><H><T><G><H><Q><D><K><V><R><C><F><F><C><Y><G><G><L><Q><S><W><K><R><G><D><D><P><W><T><E><H><A><K><W><F><P><S><C><Q><F><L><L><R><S><K><G><R><D><F><V><H><S><V><Q><E><T><H><S><Q><L><L><G><S><W><D><P><W><E><E><P><E><D><A><A><P><V><A><P><S><V><P><A><S><G><Y><P><E><L><P><T><P><R><R><E><V><Q><S><E><S><A><Q><E><P><G><G><V><S><P><A><E><A><Q><R><A><W><W><V><L><E><P><P><G><A><R><D><V><E><A><Q><L><R><R><L><Q><E><E><R><T><C><K><V><C><L><D><R><A><V><S><I><V><F><V><P><C><G><H><L><V><C><A><E><C><A><P><G><L><Q><L><C><P><I><C><R><A><P><V><R><S><R><V><R><T><F><L><S>
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Blocks etoposide-induced apoptosis . Protects against natural killer (NK) cell-mediated killing .<BOP>
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Q96CA5
|
Q92670
|
ZN75C_HUMAN
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Zinc finger protein 75C pseudogene
|
Homo
|
<M><I><M><R><E><L><K><A><D><A><C><L><N><S><H><M><G><A><M><W><E><T><N><R><S><V><K><E><N><S><S><Q><S><K><K><Y><S><T><Q><I><E><C><L><S><P><G><S><A><C><R><H><F><R><S><F><H><Y><H><E><A><T><E><P><L><E><A><I><N><Q><L><Q><K><L><C><H><Q><W><L><R><P><E><I><H><S><K><K><H><I><L><E><M><L><V><L><E><H><F><L><T><I><L><P><K><G><T><Q><N><W><V><Q><K><H><H><P><Q><L><A><K><Q><A><L><V><L><V><E><R><L><Q><R><E><P><G><G><T><K><N><E><V><T><A><H><E><L><G><E><E><A><V><L><L><R><G><T><T><V><A><P><G><F><K><W><K><P><A><E><L><E><P><M><E><R><I><L><E><H><I><Q><I><L><A><L><S><E><H><K><S><T><K><D><W><K><M><A><P><K><L><I><W><P><E><S><Q><S><L><L><T><F><E><D><M><A><V><Y><F><S><E><E><E><W><Q><L><L><G><P><L><E><K><T><L><Y><N><D><V><M><Q><D><I><Y><E><T><A><I><S><L><G><K><Q><R><T><G><K><I><M><G><I><E><M><A><S><S><F><S><K><E><E><K><K><L><T><T><C><K><Q><E><L><P><K><L><M><D><L><H><G><K><G><H><T><G><E><K><P><F><K><C><Q><D><C><G><K><I><F><R><V><S><S><D><L><I><K><H><Q><R><I><H><T><E><E><K><L><Y><K><C><Q><Q><C><D><R><R><F><R><W><S><S><G><L><N><K><H><F><M><T><H><Q><G><I><N><P><Y><R><C><S><W><Y><G><K><S><I><S><Y><D><T><N><L><Q><T><H><Q><R><I><H><T><G><E><K><P><F><K><C><H><E><C><G><K><I><F><I><H><K><S><N><L><I><K><Y><Q><R><T><H><T><G><E><Q><P><Y><T><C><S><I><C><R><R><N><F><S><R><Q><L><S><L><L><R><H><Q><K><L><H>
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May be involved in transcriptional regulation.<BOP>
|
Q92670
|
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