id stringlengths 6 8 | question stringlengths 17 664 | context listlengths 1 12 | response stringlengths 1 3.12k | answer stringclasses 3
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19471574 | Is uterine corpus involvement as well as histologic type an independent predictor of ovarian metastasis in uterine cervical cancer? | [
"This study aimed to investigate the independent risk factors for ovarian metastasis in cervical cancer.",
"Among 1,040 consecutive patients who underwent operation for cervical cancer at our institution from January 1998 to July 2007, a total of 625 patients had both ovaries removed during primary operation were... | Based on our study, uterine involvement of cervical cancer is an independent predictor for ovarian metastasis, except histologic types. Ovarian preservation in cervical cancer may be safely performed only when no involvement of uterine corpus is present. | yes |
27788062 | Does detection of Leishmania infantum and a Novel Phlebovirus ( Balkan Virus ) from Sand fly in Albania? | [
"To organize entomological campaigns to trap sand flies in selected regions of Albania and to test them for the presence of existing or new phleboviruses and for leishmania DNA.",
"Sand flies were collected in 14 locations from May to October 2014 using three different types of traps. Pools with a maximum of 30 i... | Visceral leishmaniasis has been clinically recognized in Albania for at least 80 years; however, this is the first time that L. infantum, detected by molecular means, has been reported in sand flies in Albania. At the outset of this study, only Adria virus (Salehabad species) was recognized in Albania. A novel virus, B... | yes |
16029839 | Does the risk of preeclampsia rise with increasing prepregnancy body mass index? | [
"To explore the dose-dependent relation between prepregnancy body mass index (BMI) and the risk of preeclampsia after adjusting for measured confounders.",
"We studied 1179 primiparous women who enrolled at < 16 weeks' gestation into a prospective cohort study of the pathogenesis of preeclampsia. Multivariable lo... | These results indicate that preeclampsia risk rises through most of the BMI distribution. The dramatic elevation in overweight prevalence in the United States may increase preeclampsia incidence in the future. | yes |
22768815 | Do [ Medical students ' pleasure for participating in peer assessment ]? | [
"to explore the agreement of medical students (MS) with the statement \"I liked participating in my peers' assessment\" and the explanations why.",
"the peer assessment of 411 MS who participated consisted in assessing audiovisual lectures presented by their classmates using rubrics. Then, they classified their g... | knowing the explanations given by the MS to support their agreement with the pleasure for participating in peer assessment allows a more adequate approach to conflicts. | yes |
16198935 | Are young hemodialysis patients exposed to hyperhomocysteinemia? | [
"Homocysteine is one of the cardiovascular risk factors in hemodialysis (HD) patients. Studies were performed to assess the effects of folic acid on pulse wave velocity (PWV) in HD patients.",
"In a cross-sectional study, plasma total homocysteine (tHcy) was measured in 49 patients on maintenance HD. Ten HD patie... | The present findings indicate that young HD patients are exposed to severe hyperhomocysteinemia, and suggest that relatively large doses of folic acid attenuate progressive increases in PWV of young or middle-age HD patients. | yes |
25528444 | Do low levels of lipopolysaccharide modulate mitochondrial oxygen consumption in skeletal muscle? | [
"We have previously demonstrated that activation of toll-like receptor 4 (TLR4) in skeletal muscle results in an increased reliance on glucose as an energy source and a concomitant decrease in fatty acid oxidation under basal conditions. Herein, we examined the effects of lipopolysaccharide (LPS), the primary ligan... | LPS exposure in skeletal muscle alters mitochondrial oxygen consumption and substrate preference, which is absent when antioxidants are present. | yes |
25172602 | Does first outcome result after total knee and hip replacement from the Lithuanian arthroplasty register? | [
"In 2010, the Lithuanian Association of Arhtroplasty was established and on January 1, 2011, initiated a national study of all reoperations after total knee (TKR) and total hip replacement (THR) in Lithuania. The aim of the study was to investigate the revision rates after TKR and THR at two years follow-up.",
"L... | The overall survival after total knee and hip replacements revealed a high treatment quality of this surgery in Lithuania. | yes |
21308889 | Are stressful life events at onset of obsessive-compulsive disorder associated with a distinct clinical pattern? | [
"Environmental stressors are considered to play an important role in the triggering of mental disorders such as obsessive-compulsive disorder (OCD). Although there is extensive literature on traumatic life events, little is known about the role of nontraumatic but nonetheless stressful life events (SLEs) in OCD. Th... | Patients with OCD onset close to an SLE and those without an SLE close to OCD onset show a distinct clinical pattern. | yes |
21649463 | Do knockdown of β-Catenin through shRNA cause a reversal of EMT and metastatic phenotypes induced by HIF-1α? | [
"Wnt/β-catenin signaling pathway regulates pattern formation during embryogenesis as well as tumor progression. Numbers of studies suggest that this signaling pathway may play an important role in Epithelial-Mesenchymal transition (EMT), however, there was no evidence that Wnt/β-catenin signaling pathway directly c... | Overexpression of HIF-1α stimulates the invasion potency of human prostate carcinoma cells through EMT pathway and Wnt/β-catenin signaling pathway played a vital role in this process. Wnt/β-catenin signaling pathway might be a necessary endogenous signal that directly controlled the EMT occurrence induced by HIF-1α. | yes |
18045886 | Does an alcohol oxidase dipstick rapidly detect methanol in the serum of mice? | [
"Patients presenting with ingestions of methanol and ethylene glycol pose a significant challenge to emergency physicians. The decision to initiate antidotal therapy must be made quickly and is currently based on the presence of indirect signs, symptoms, and laboratory tests, because no real-time diagnostic test ex... | A commercially available dipstick that uses an alcohol oxidase colorimetric reaction reliably and rapidly detects very low serum concentrations of methanol but not ethylene glycol in this animal model. This color change is easily detected by most observers. | yes |
9755007 | Is vascular rejection post heart transplantation associated with positive flow cytometric cross-matching? | [
"Use of flow cytometry cross-matching for measurement of donor-specific alloreactivity and monitoring anti-donor antibodies is well established. This study was performed to determine (1) its accuracy as a marker of vascular rejection, (2) its correlation with post-transplant outcome and (3) its ability to monitor h... | Flow cytometry cross-matching provides a valuable marker for the detection of vascular rejection after cardiac transplantation. Quantitative measurements may allow evaluation of the efficacy of treatment modalities employed in the management of vascular rejection in an attempt to improve outcome. | yes |
20884925 | Do aspergillosis of the maxillary sinus associated with a zygomatic implant? | [
"The use of a specially designed implant to be anchored in the zygomatic bone has been proposed in the literature as an alternative to bone grafting in the prosthetic rehabilitation of the severely resorbed maxilla, an option that has few postoperative complications. However, some complications can arise, such as t... | Zygomatic implant placement is a safe surgical procedure. Nevertheless, postoperative maxillary sinus infections by bacteria, virus and fungus can occur and therefore need to be considered in the diagnosis of infection in the vicinity of dental and maxillofacial implants. | yes |
9170003 | Does sodium intake regulate renin gene expression differently in the hypothalamus and kidney of rats? | [
"To elucidate the different effects of sodium intake on renin messenger RNA (mRNA) in the hypothalamus and the kidney and to investigate the role of hypothalamic renin in sodium-induced hypertension.",
"We investigated the expression of the renin gene in the hypothalamus and the kidney of rats with altered sodium... | The expression of the renin gene is regulated differently in the rat hypothalamus from that in the kidney. The constant expression of the renin gene in the hypothalamus during a chronic high sodium load might be related at least in part to the mechanism of the activated brain renin-angiotensin system in sodium-induced ... | yes |
23405158 | Are soluble TNF receptors associated with infarct size and ventricular dysfunction in ST-elevation myocardial infarction? | [
"The aim of the study was to investigate circulating markers of apoptosis in relation to infarct size, left ventricular dysfunction and remodeling in an ST-elevation myocardial infarction (STEMI) population undergoing primary percutaneous coronary intervention (PCI).",
"Immediate re-opening of the acutely occlude... | In STEMI patients, circulating levels of sTNFR1 and sTNFR2 are associated with infarct size and LV dysfunction. This provides further evidence for the role of apoptosis in ischemia-reperfusion injury. | yes |
22367996 | Does loss of junctophilin-3 contribute to Huntington disease-like 2 pathogenesis? | [
"Huntington disease-like 2 (HDL2) is a progressive, late onset autosomal dominant neurodegenerative disorder, with remarkable similarities to Huntington disease (HD). HDL2 is caused by a CTG/CAG repeat expansion. In the CTG orientation, the repeat is located within the alternatively spliced exon 2A of junctophilin-... | Our results suggest that the pathogenic mechanism of HDL2 is multifactorial, involving both a toxic gain of function of JPH3 RNA and a toxic loss of JPH3 expression. | yes |
15221308 | Do partially reversible quadruple sectoranopia caused by vascular steal due to an arteriovenous malformation? | [
"Lateral, homonymous upper and lower field blind sectors sparing a horizontal zone define quadruple sectoranopia. This rare campimetric deficit involves ischemia or infarction of parts of the lateral geniculate body supplied by the distal anterior choroidal artery.",
"A 41-year-old patient presented with a compla... | Quadruple sectoranopia involves ischemia or infarction of parts of the lateral geniculate body supplied by the distal anterior choroidal artery. Following radio-induced angioma thrombosis, blood was no longer shunted away from the right lateral geniculate body, whose viable areas resumed their activity. Accordingly, a ... | yes |
27161025 | Does chronic Stress be Associated with Indicators of Diet Quality in Habitual Breakfast Skippers? | [
"Previous studies suggest skipping breakfast is associated with lower diet quality, but possible reasons underlying this relationship are not clear.",
"Our aim was to determine the relationship between chronic stress and variations in diet quality in the context of breakfast eating or breakfast skipping.",
"Bas... | Breakfast skippers were less likely to meet the Dietary Guidelines for Americans and consumed more empty calories at night. Chronic stress was related to evening eating choices and overall empty calories in the diet of breakfast skippers, whereas breakfast eaters' dietary intake did not appear to be affected by chronic... | yes |
18802019 | Do common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13? | [
"Background- Variation in LDL-cholesterol (LDL-C) among individuals is a complex genetic trait involving multiple genes and gene-environment interactions.",
"In a genome-wide association study (GWAS) to identify genetic variants influencing LDL-C in an isolated population from Kosrae, we observed associations for... | We identified variants in HMGCR that are associated with LDL-C across populations and affect alternative splicing of HMGCR exon13. | yes |
16326102 | Is sAK/PLK4 required for centriole duplication and flagella development? | [
"SAK/PLK4 is a distinct member of the polo-like kinase family. SAK-/- mice die during embryogenesis, whereas SAK+/- mice develop liver and lung tumors and SAK+/- MEFs show mitotic abnormalities. However, the mechanism underlying these phenotypes is still not known.",
"Here, we show that downregulation of SAK in D... | SAK/PLK4 is necessary for centriole duplication both in Drosophila and human cells. Drosophila cells tolerate the lack of centrioles and undertake mitosis but cannot form basal bodies and hence flagella. Human cells depleted of SAK show error-prone mitosis, likely to underlie its tumor-suppressor role. | yes |
11849383 | Does impairment of vascular regeneration precede progressive glomerulosclerosis in anti-Thy 1 glomerulonephritis? | [
"It has been proposed that glomerular hemodynamic changes or glomerular growth response may promote the development of glomerulosclerosis, irrespective of its etiology. Further experimental models are needed to clarify the cellular and molecular mechanisms that lead to progressive glomerulosclerosis with an irrever... | Progressive glomerulosclerosis can be induced in the rat by a one shot injection of anti-Thy 1.1 monoclonal antibody followed by unilateral nephrectomy. This model shows that there is a positive association between impairment of vascular regeneration and the development of glomerulosclerosis. | yes |
21861142 | Is sOX9 expressed in normal stomach , intestinal metaplasia , and gastric carcinoma in humans? | [
"SOX9 is a marker for stem cells in the intestine and overexpression of SOX9 is found in some types of cancer. However, the expression of SOX9 in normal stomach, precancerous intestinal metaplasia, and gastric carcinoma has not yet been clarified. This study aimed to investigate SOX9 expression in the corpus and py... | SOX9 is expressed in intestinal metaplasia and gastric carcinoma in humans. | yes |
9258087 | Does deoxyribonucleic acid ploidy enhance the cytological prediction of recurrent transitional cell carcinoma of the bladder? | [
"We determined whether deoxyribonucleic acid (DNA) ploidy analysis by image analysis cytometry enhances the cytological diagnosis of recurrent transitional cell carcinoma of the bladder.",
"A retrospective study was performed during a 5-year period to evaluate the cytological diagnosis and DNA ploidy analysis of ... | Abnormal DNA ploidy determined by image analysis significantly enhances the detection of bladder tumor recurrence in patients with atypical or dysplastic cytology but not in those with normal cytology or frank carcinoma on cytological findings. | yes |
21552497 | Is a recurrent mutation in CRYGD associated with autosomal dominant congenital coralliform cataract in two unrelated Chinese families? | [
"Congenital cataract is a clinically and genetically heterogeneous lens disorder. The purpose of this study was to identify the mutation responsible for autosomal dominant congenital coralliform cataracts in two Chinese families and to investigate the relationship between virulence genes and lens morphology.",
"P... | Our results indicated that the P24T mutation of CRYGD was responsible for two Chinese pedigrees with congenital coralliform cataracts. CRYGD and coralliform cataracts are highly related, and P24T may be a hot-point mutation for this disorder. | yes |
24499477 | Does low copy number of mitochondrial DNA ( mtDNA ) predict worse prognosis in early-stage laryngeal cancer patients? | [
"Alterations in mitochondrial DNA (mtDNA) copy number have been widely reported in various human cancers, and been considered to be an important hallmark of cancers. However, little is known about the value of copy number variations of mtDNA in the prognostic evaluation of laryngeal cancer.",
"Using real-time qua... | The present study demonstrated that low mtDNA content was strongly correlated with some of clinicopathological characteristics, such as cigarette smoking, tumor invasion and TNM stage. In addition, we found a strong link between low mtDNA content and worse survival of the patients with early-stage tumors. Taken togethe... | yes |
23053888 | Does rapid on-site evaluation increase endoscopic ultrasound-guided fine-needle aspiration adequacy for pancreatic lesions? | [
"Rapid on-site evaluation (ROSE) has the potential to improve adequacy rates and affect other outcomes; however, there have been few comparative studies to assess the impact of ROSE in the setting of ultrasound-guided endoscopic fine-needle aspiration cytology for pancreatic lesions.",
"To determine whether ROSE ... | ROSE is associated with an improvement in adequacy rates when implemented at sites where the per-case adequacy rate without ROSE is low (<90 %). It is unclear whether the type of assessor (pathologist vs. non-pathologist) has a significant impact on the success rate of ROSE. ROSE has no impact on diagnostic yield. Stud... | yes |
9661765 | Is adaptive bone modeling in the middle ear substance-P dependent? | [
"Localized bone modeling in the middle ear is substance-P dependent.",
"Processes of local bone modeling and remodeling in the middle and inner ear lead to destructive processes such as otosclerosis and chronic otitis media. The cellular events associated with these processes are known, but the mechanisms of the ... | It is likely that substance-P is a mediator of localized adaptive bone modeling in vivo. Processes of bone modeling and remodeling in the middle and inner ear may be under neural control. | yes |
27141235 | Does the Salmonella pathogenicity island 13 contribute to pathogenesis in streptomycin pre-treated mice but not in day-old chickens? | [
"Salmonella enterica serovar Enteritidis (S. Enteritidis) is a human and animal pathogen that causes gastroenteritis characterized by inflammatory diarrhea and occasionally an invasive systemic infection. Salmonella pathogenicity islands (SPIs) are horizontally acquired genomic segments known to contribute to Salmo... | The results of this study show that SPI-13 contributes to the pathogenesis of S. Enteritidis in streptomycin pre-treated mice but not in day-old chickens and raises the possibility that SPI-13 may play a role in pathogenesis and the host adaptation/restriction of Salmonella serovars. | yes |
8548290 | Is the chk1 pathway required to prevent mitosis following cell-cycle arrest at 'start '? | [
"The G2-M-phase transition is controlled by cell-cycle checkpoint pathways which inhibit mitosis if previous events are incomplete or if the DNA is damaged. Genetic analyses in yeast have defined two related, but distinct, pathways which prevent mitosis--one which acts when S phase is inhibited, and one which acts ... | Genetic dissection of checkpoints in logarithmically growing fission yeast has identified a pathway that couples mitosis to correct passage through start. This pathway is related to the DNA-structure check-points which ensure that mitosis is dependent on the completion of replication and the integrity of the DNA. We pr... | yes |
20609236 | Do breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition? | [
"Epithelial to mesenchymal transition (EMT), implicated as a mechanism for tumor dissemination, is marked by loss of E-cadherin, disruption of cell adhesion, and induction of cell motility and invasion. In most intraductal breast carcinomas E-cadherin is regulated epigenetically via methylation of the promoter. E-c... | Our clinical observations and experimental data indicate that the secondary organ microenvironment can induce the re-expression of E-cadherin and consequently MErT. This phenotypic change is reflected in altered cell behavior and thus may be a critical step in cell survival at metastatic sites. | yes |
21992195 | Does high-frequency cortical stimulation augment recovery of thalamocortical oscillations from hypoxia in rat brain slices? | [
"Cerebrovascular hypoxia results in severe impairment and electrical dysfunction of cortical and thalamic neuronal networks. Typically cellular electrical activity returns if reoxygenation is established within 5-8 min. Electrical stimulation has been shown to reduce cellular apoptosis following cerebral hypoxia in... | High-frequency cortical stimulation accelerated the recovery of thalamocortical network activity following hypoxia and reperfusion. Insight into the underlying mechanisms of this effect may enhance therapeutic interventions related to hypoxia following ischemic stroke. | yes |
16875106 | Does six Sigma arise from the ashes of TQM with a twist? | [
"This paper sets out to analyse the use of the Six Sigma methodology to improve quality in healthcare. It looks at how Six Sigma grew out of the concept of Total Quality Management (TQM).",
"Six Sigma is a quality improvement methodology that has been widely adopted by companies since the early 1990s and has grow... | On each project, intense study is used to determine root cause analysis; and in the end, a metric known as "sigma level" can be assigned to signify the level of quality. Six Sigma has a "critical to quality" dimension that keeps the quality effort focused on improving only those things that really matter to the custome... | yes |
8053078 | Does ondansetron stimulate prolactin release in breast cancer patients? | [
"Prolactin (PRL) may be a tumor growth factor, mainly for breast cancer. The antidopaminergic drugs commonly used in the treatment of chemotherapy-induced vomiting stimulate PRL release, and this finding could represent a potentially negative biologic event for cancer patients. This study was performed to analyze P... | The study showed that ondansetron, whose efficacy in the treatment of chemotherapy-induced vomiting is well known, does not stimulate the tumor growth factor PRL in cancer patients, in contrast the the action of the most commonly used antidopaminergic drugs. | no |
26010685 | Does glibenclamide improve Survival and Neurologic Outcome After Cardiac Arrest in Rats? | [
"Glibenclamide confers neuroprotection in animal models as well as in retrospective clinical studies. This study determines whether glibenclamide improves outcome after cardiac arrest in rats.",
"Prospective randomized laboratory study.",
"University research laboratory.",
"Male Sprague-Dawley rats (n = 126).... | Glibenclamide treatment substantially improved survival and neurologic outcome throughout a 7-day period after return of spontaneous circulation. The salutary effects of glibenclamide were associated with suppression of neuronal necrosis and apoptosis, as well as inflammation in the brain. | yes |
21204958 | Does nateglinide provide tighter glycaemic control than glyburide in patients with Type 2 diabetes with prevalent postprandial hyperglycaemia? | [
"Postprandial hyperglycaemia in patients with Type 2 diabetes mellitus has been linked to the development of cardiovascular disease. This study compared the effects of mealtime (thrice-daily) nateglinide with once-daily glyburide on postprandial glucose levels in patients with Type 2 diabetes and postprandial hyper... | Nateglinide leads to greater reductions in postprandial glucose excursions and is associated with a lower risk of hypoglycaemia than glyburide in this selected population of patients with Type 2 diabetes. | yes |
22726711 | Does coping among parents of children with special health care need with and without a health care home? | [
"Having a health care home has been shown to be associated with positive health outcomes for children with special health care needs (CSHCN), but its relationship to parental coping has not been established. The purpose of this study was to explore the health care home as a process of care related to parental copin... | Results suggest that the health care home represents a process of care that may help families manage the daily demands of caring for CSHCN through family-centered care, provider-to-provider communication, and provision of care coordination. | yes |
21060890 | Does antioxidant biomarkers from Vanda coerulea stem reduce irradiated HaCaT PGE-2 production as a result of COX-2 inhibition? | [
"In our investigations towards the isolation of potentially biologically active constituents from Orchidaceae, we carried out phytochemical and biological analyses of Vanda species. A preliminary biological screening revealed that Vanda coerulea (Griff. ex. Lindl) crude hydro-alcoholic stem extract displayed the be... | Major antioxidant stilbenoids (1-3) from Vanda coerulea stems displayed an inhibition of UV(B)-induced COX-2 expression. Imbricatin (1) and methoxycoelonin (2) were also able to inhibit COX-2 activity in a concentration-dependent manner thereby reducing PGE-2 production from irradiated HaCaT cells. Our studies suggest ... | yes |
19308751 | Is maternal serum endostatin at gestational weeks 16-20 elevated in subsequent pre-eclampsia but not in intrauterine growth retardation? | [
"Endostatin, an important anti-angiogenic factor produced by endothelial cells, is elevated in established pre-eclampsia. We measured maternal serum endostatin concentrations in early pregnancy associated with later pre-eclampsia and intrauterine growth retardation (IUGR).",
"Retrospective case-control study.",
... | The concentrations of endostatin in maternal serum at 16-20 weeks' of gestation are associated with an increased risk of pre-eclampsia but not IUGR. | yes |
20489098 | Does mRI feature in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas? | [
"The objective of this study was to identify the MRI criteria that best differentiate malignant peripheral nerve sheath tumors from benign neurofibromas.",
"We retrospectively analyzed MR images obtained for 41 histologically diagnosed cases of malignant peripheral nerve sheath tumor and 20 cases of neurofibroma ... | The MR features described in this study are useful for distinguishing malignant peripheral nerve sheath tumors from neurofibromas. If a tumor has two or more of the four statistically significant features, it can be considered to be highly suspicious of malignancy and should be subjected to a biopsy for early diagnosis... | yes |
23709640 | Does ambient fine particulate matter alter cerebral hemodynamics in the elderly? | [
"Short-term elevations in fine particulate matter air pollution (PM2.5) are associated with increased risk of acute cerebrovascular events. Evidence from the peripheral circulation suggests that vascular dysfunction may be a central mechanism. However, the effects of PM2.5 on cerebrovascular function and hemodynami... | In this cohort of community-dwelling seniors, exposure to PM2.5 was associated with higher resting cerebrovascular resistance and lower cerebral blood flow velocity. If replicated, these findings suggest that alterations in cerebrovascular hemodynamics may underlie the increased risk of particle-related acute cerebrova... | yes |
24161555 | Is microcirculatory perfusion preserved during off-pump but not on-pump cardiac surgery? | [
"This study investigated the perioperative course of microcirculatory perfusion in off-pump compared with on-pump surgery. Additionally, the impact of changes in systemic hemodynamics, hematocrit, and body temperature was studied.",
"Prospective, nonrandomized, observational study.",
"Tertiary university hospit... | Microcirculatory perfusion remained unaltered throughout off-pump surgery. In contrast, microvascular perfusion declined after initiation of cardiopulmonary bypass and did not recover in the early postoperative phase. | yes |
25471445 | Is magnetic suppression of perceptual accuracy reduced in episodic migraine without aura? | [
"Altered cortical excitability is thought to be part of migraine pathophysiology. Reduced magnetic suppression of perceptual accuracy (MSPA) has been found in episodic migraine with aura and in chronic migraine, and has been interpreted as reduced inhibition of the occipital cortex in these migraine subtypes. Resul... | The results demonstrate that occipital cortex inhibition as assessed with MSPA is not reduced in episodic migraine without aura. This suggests a larger role of occipital cortex excitability in episodic migraine with aura and in chronic migraine compared to episodic migraine without aura. Test-retest reliability of MSPA... | no |
10656213 | Is increased incidence of anti-cardiolipin antibodies in patients with hepatitis C associated with aetiopathogenetic link to anti-phospholipid syndrome? | [
"Chronic infection with hepatitis C virus (HCV) has been found to be associated with various diseases known as extra-hepatic manifestations of HCV. Recently, HCV has been implicated as a cause of the antiphospholipid syndrome (APLS). We conducted a study in a well-characterized area for epidemiological and prospect... | A significant proportion of HCV patients (37.3%) had detectable anti-CL of low titre. However, this finding was not associated with the development of APLS. On the other hand, none of the APLS patients was positive for HCV. Taken together, our data rather failed to reveal an aetiopathogenetic link between HCV and APLS.... | no |
23988382 | Does progesterone negatively regulate BCRP in progesterone receptor-positive human breast cancer cells? | [
"Breast cancer resistance protein (BCRP) plays a crucial role in multidrug resistance (MDR). Previous studies have shown that steroid hormones, like progesterone (PROG), regulate BCRP expression. The presence of a progesterone response element (PRE) in the BCRP promoter, suggests that PROG may regulate transcriptio... | These results suggest that PROG reverses BCRP-mediated MDR by down-regulating BCRP expression in breast cancer cells by affecting transcription from the PRE-containing BCRP promoter. Our studies suggest that breast cancer patients with BCRP-mediated MDR may be successfully treated with PROG. | yes |
26443972 | Does interval and continuous exercise enhance aerobic capacity and hemodynamic function in CHF rats? | [
"The aim of the present study was to compare the effects of continuous versus interval aerobic exercise training on hemodynamic parameters, cardiac remodeling, and maximal exercise capacity (MEC) in chronic heart failure (CHF) rats.",
"Twenty-four male Wistar rats were subjected to myocardial infarction (MI) surg... | Aerobic training is an important intervention to improve cardiac function and remodeling and physical capacity in CHF rats. Interval training is a potential strategy to maximize the results, but exercise type and intensity are still topics to be explored. | yes |
10593788 | Does current outpatient management of asthma show poor compliance with International Consensus Guidelines? | [
"This study aimed to establish whether the outpatient management of patients presenting with an asthma exacerbation to the emergency department (ED) was in compliance with the 1992 guidelines of the \"International Consensus Report on the Diagnosis and Management of Asthma.\"",
"Prospective, observational study u... | The outpatient management of most asthma patients presenting to the ED did not comply with the consensus guidelines, and asthma knowledge was poor. | yes |
22065308 | Does the chemical compound PTC124 affect cellular electrophysiology of cardiac ventricular myocytes? | [
"Nonsense mutations that create premature termination codons (PTC) leading to disease by a mechanism of haploinsufficiency are relatively common in the SCN5A gene encoding the major sodium channel in heart. PTCs in SCN5A are associated with isolated conduction disease and Brugada syndrome (BrS). Pharmacological the... | PTC124 has no acute or long-term effects on rabbit ventricular action potentials. These experiments form the basis for future studies evaluating the use of this therapy in preventing potentially lethal arrhythmias in patients with BrS and/or conduction disease. | no |
27546592 | Does inorganic polyphosphate promote cyclin D1 synthesis through activation of mTOR/Wnt/β-catenin signaling in endothelial cells? | [
"Essentials Polyphosphate (polyP) activates mTOR but its role in Wnt/β-catenin signaling is not known. PolyP-mediated cyclin D1 expression (β-catenin target gene) was monitored in endothelial cells. PolyP and boiled platelet-releasates induced the expression of cyclin D1 by similar mechanisms. PolyP establishes cro... | Background Inorganic polyphosphate (polyP) elicits intracellular signaling responses in endothelial cells through activation of mTOR complexes 1 and 2. Glycogen synthase kinase 3 (GSK-3) is known to be a negative regulator of mTOR and Wnt/β-catenin signaling pathways. Objective The objective of this study was to invest... | yes |
26797719 | Does pokemon promote the invasiveness of hepatocellular carcinoma by enhancing MEF2D transcription? | [
"Pokemon, a master oncogene crucial for the tumorigenicity and progression of a variety of cancers, has been demonstrated to enhance the proliferation and survival of hepatocellular carcinoma (HCC). However, the contribution of Pokemon to the invasiveness of HCC has not yet been studied.",
"In this study, we empl... | Collectively, Pokemon was found to enhance the migration and invasion of HCC by increasing MEF2D expression. Thus, targeting Pokemon and MEF2D may be an effective strategy to suppress the metastasis of HCC. | yes |
17198874 | Does all-trans retinoic acid induce proliferation of an irradiated stem cell supporting stromal cell line AFT024? | [
"We have previously shown that all-trans retinoic acid (ATRA) enhanced the maintenance of early human hematopoietic progenitor cells (HPCs) in the presence of an irradiated stromal cell line AFT024. In this study, we examined the effects of ATRA on the stromal cell component with particular reference to cellular pr... | We concluded that ATRA induced cellular proliferation of irradiated AFT024 cells and expression of a number of genes whose relevance to HPC homeostasis would have to be further examined. | yes |
27046669 | Do maladaptive trauma appraisals mediate the relation between attachment anxiety and PTSD symptom severity? | [
"In a large sample of community-dwelling older adults with histories of exposure to a broad range of traumatic events, we examined the extent to which appraisals of traumatic events mediate the relations between insecure attachment styles and posttraumatic stress disorder (PTSD) symptom severity.",
"Participants ... | Our findings suggest that attachment anxiety contributes to greater PTSD symptom severity through heightened perceptions of traumatic events as central to identity and severe. (PsycINFO Database Record | yes |
23216529 | Are small Bacillus cereus ATCC 14579 subpopulations responsible for cytotoxin K production? | [
"Bacillus cereus diarrhoeal food poisoning can be caused by several potential enterotoxins, including the nonhaemolytic enterotoxin (Nhe), haemolysin BL (Hbl) and cytotoxin K (CytK). To get more insights into the CytK expression, a fluorescent reporter strain was created for CytK expression.",
"Bacillus cereus AT... | These results suggest that a small subpopulation of B. cereus ATCC 14579 is responsible for CytK production in a homogeneous monoculture. | yes |
25862895 | Does initial incomplete surgery modify prognosis in advanced ovarian cancer regardless of subsequent management? | [
"Prognosis in ovarian cancer is determined by completeness of cytoreduction and proper management by specialized oncological gynecologists. Incomplete initial debulking surgery in non-specialized Centers is, however, a reality and there is ongoing discussion about the best subsequent management of such patients.",
... | Primary biopsy or incomplete cytoreduction reduces survival regardless of the subsequent approach. However, if incomplete cytoreduction has occurred, neoadjuvant chemotherapy followed by IDS is preferable to up-front reoperation. | yes |
24702903 | Is vitamin D receptor polymorphism FokI associated with spontaneous idiopathic preterm birth in an Israeli population? | [
"The active form of vitamin D (1,25[OH]2D3) has been established to have potent anti-proliferative, immuno-modulatory, and anti-microbial action in addition to its effects on bone. The nuclear vitamin D receptor (VDR) is expressed in the placenta-decidua, regulating genes associated with implantation and implantati... | This study may support a future platform for the study of vitamin D during pregnancy and treatment of selective target populations with vitamin D and/or VDR "tissue-specific therapeutic intervention" for prevention of PTB. | yes |
22259058 | Is heart failure a clinically and densitometrically independent risk factor for osteoporotic fractures : population-based cohort study of 45,509 subjects? | [
"The aim of the study was to determine whether heart failure is associated with an increased risk of major osteoporotic fractures that is independent of bone mineral density (BMD).",
"We conducted a population-based cohort study in Manitoba, Canada, by linking a clinical registry of all adults 50 yr of age and ol... | Heart failure is associated with a 30% increase in major fractures that is independent of traditional risk factors and BMD, and it also identifies a high-risk population that may benefit from increased screening and treatment for osteoporosis. | yes |
23429816 | Does antenatal depression strongly predict postnatal depression in primary health care? | [
"To estimate the association between antenatal and postnatal depression and to examine the role of socioeconomic conditions in the risk of postnatal depression.",
"A prospective cohort study, conducted between May 2005 and January 2006, with 831 pregnant women recruited from primary care clinics in the public sec... | Antenatal and postnatal depression are highly prevalent in the primary care setting. | yes |
21320039 | Does neonatal exposure to herbicide acetochlor alter pubertal development in female wistar rats? | [
"The purpose of this study was to evaluate the effects of neonatal exposure to the herbicide acetochlor (ACT) on pubertal development and reproductive functions in female Wistar rats and to investigate capability of ACT to interfere with estradiol binding to rat uterine estrogen receptors (ERs) ex vivo.",
"Acetoc... | These results indicate that acetochlor can act as the endocrine disruptor and that endpoints related to pubertal development and reproductive functions sensitive sites are targeted with this persistent pollutant. | yes |
22884970 | Does ghrelin signaling in the ventral hippocampus stimulate learned and motivational aspects of feeding via PI3K-Akt signaling? | [
"The stomach-derived hormone ghrelin drives higher-order feeding processes related to food reward and food seeking via central nervous system signaling at its receptor (GHSR1A). The specific nuclei mediating these effects are only partially understood. Here, we use a rat model to examine whether ghrelin signaling i... | These findings illuminate novel neuronal and behavioral mechanisms mediating ghrelinergic control of cognitive aspects of feeding control. | yes |
17362257 | Does public data mining show extended linkage disequilibrium around ADAM33? | [
"ADAM33 has been described to be the first positional cloned asthma gene. Consecutive association studies have found inconsistent results. At present no functional relevant variation is being known.",
"Aim of the study was to test if genes in close physical distance could also be responsible for the observed link... | Resequencing of the ADAM33 region including GFRA4, ATRN and SN is expedient. | yes |
22125633 | Does a SELEX-screened aptamer of human hepatitis B virus RNA encapsidation signal suppress viral replication? | [
"The specific interaction between hepatitis B virus (HBV) polymerase (P protein) and the ε RNA stem-loop on pregenomic (pg) RNA is crucial for viral replication. It triggers both pgRNA packaging and reverse transcription and thus represents an attractive antiviral target. RNA decoys mimicking ε in P protein binding... | This study demonstrates the first successful identification of human HBV ε aptamers by an in vitro SELEX approach. Effective suppression of HBV replication by the S9 aptamer provides proof-of-principle for the ability of ε decoy RNAs to interfere with viral P-ε complex formation and suggests that S9-like RNAs may furth... | yes |
15480311 | Does corticotropin-releasing hormone deficiency increase allergen-induced airway inflammation in a mouse model of asthma? | [
"Corticotropin-releasing hormone (CRH) is a major regulator of adrenocorticotropic hormone and the production of glucocorticoids by the adrenal gland. Abnormal regulation of CRH and endogenous glucocorticoids has been implicated in the pathogenesis of asthma.",
"We postulated that CRH deficiency could increase as... | We conclude that CRH deficiency disrupts endogenous glucocorticoid production and enhances allergen-induced airway inflammation and lung mechanical dysfunction in mice. Thus inherited or acquired CRH deficiency could increase asthma severity in human subjects. | yes |
20588237 | Does melatonin restore the basal level of lipid peroxidation in rat tissues exposed to potassium bromate in vitro? | [
"Potassium bromate (KBrO3) is a prooxidant and carcinogen. Melatonin is a highly effective antioxidant. Indole-3-propionic acid (IPA; indole substance) and propylothiouracil (PTU; antithyroid drug) reveal some antioxidative effects. The aim of the study was to evaluate KBrO3-induced lipid peroxidation (LPO) in vitr... | Potassium bromate-induced LPO in the rat lung homogenates suggests that the lung may be the target for this carcinogen. An exposure of organisms to melatonin decreases tissue sensitivity to KBrO3-induced damage, possibly by restoring the oxidative balance. | yes |
22527252 | Are humoral anti-KLH responses in cancer patients treated with dendritic cell-based immunotherapy dictated by different vaccination parameters? | [
"Keyhole limpet hemocyanin (KLH) attracts biomedical interest because of its remarkable immunostimulatory properties. Currently, KLH is used as vaccine adjuvant, carrier protein for haptens and as local treatment for bladder cancer. Since a quantitative human anti-KLH assay is lacking, it has not been possible to m... | We present the first quantitative assay to measure KLH-specific Abs in human serum, which now enables monitoring both the dynamics and absolute concentrations of humoral immune responses in individuals exposed to KLH. This assay may provide a valuable biomarker for the immunogenicity and clinical effectiveness of KLH-c... | yes |
23331966 | Does cryo-electron tomography reveal four-membrane architecture of the Plasmodium apicoplast? | [
"The apicoplast is a plastid organelle derived from a secondary endosymbiosis, containing biosynthetic pathways essential for the survival of apicomplexan parasites. The Toxoplasma apicoplast clearly possesses four membranes but in related Plasmodium spp. the apicoplast has variably been reported to have either thr... | The Plasmodium apicoplast possesses four membranes, as do the apicoplasts of other apicomplexan parasites. This is consistent with a four-membraned secondary endosymbiotic plastid ancestor. | yes |
19356424 | Is impaired coronary vasodilation by magnetic resonance angiography associated with advanced coronary artery calcification? | [
"This study evaluated the hypothesis that impaired nitroglycerin (NTG)-induced coronary vasodilation is associated with advanced coronary atherosclerosis in asymptomatic older patients.",
"Atherosclerosis is associated with both structural and functional abnormalities of the vessel wall. Noninvasive functional me... | Impaired NTG-induced coronary vasodilation by MRA is associated with advanced coronary atherosclerosis in a community-based cohort of older asymptomatic subjects. Coronary MRA may provide a noninvasive functional assessment of subclinical coronary atherosclerosis. | yes |
8988822 | Do interleukin-10 and interleukin-1 receptor antagonists increase during cardiac surgery? | [
"It has been reported that inflammatory cytokines such as interleukin-8 and 6 (IL-8, IL-6) increase during cardiac surgery and caused postoperative cardiac dysfunction. Therefore, it is important to investigate changes of suppressive cytokines such as IL-10, interleukin-4 (IL-4) and interleukin-1 receptor antagonis... | These findings demonstrate that pro- and anti-inflammatory cytokines increase to maintain their balance during cardiac surgery. | yes |
23815766 | Is knowledge insufficient for self-care among heart failure patients with psychological distress? | [
"We conducted a study to identify barriers to, and factors promoting, self-care among heart failure (HF) patients with higher or lower levels of knowledge.",
"Baseline data from 612 patients with HF enrolled in the REMOTE-HF trial were analyzed. Using median splits on the HF Knowledge Scale and the European HF Se... | Screening and treatment of depression and anxiety is important in improving self-care among HF patients. HF management programs need to include strategies for increasing patients' perceived control over their heart disease. | yes |
18957080 | Does the prokineticin receptor agonist Bv8 decrease IL-10 and IL-4 production in mice splenocytes by activating prokineticin receptor-1? | [
"Bv8, prokineticin-1, or endocrine gland-vascular endothelial growth factor, and prokineticin-2 are recently isolated peptide agonists of two G protein-coupled receptors, prokineticin receptor-1 (PROKR 1) and PROKR 2, and have been described as affecting a number of myeloid cell functions. We evaluated the impact o... | These findings indicate that Bv8/prokineticin-1 is a novel modulator of lymphoid functions, and may be a suitable target for new immunopharmacological strategies. | yes |
25048951 | Does cXCL10 play a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis? | [
"Perpetuate liver inflammation is crucial in the pathogenesis of non-alcoholic steatohepatitis (NASH). Expression of CXCL10, a pro-inflammatory cytokine, correlates positively with obesity and type 2 diabetes. Whether CXCL10 plays a role in NASH was unknown. We aimed to investigate the functional and clinical impac... | We demonstrate for the first time that CXCL10 plays a pivotal role in the pathogenesis of experimental steatohepatitis. CXCL10 maybe a potential non-invasive biomarker for NASH patients. | yes |
26142417 | Does cold-Plasma Coagulation on the Surface of the Small Bowel be Safe in Pigs? | [
"Surgical treatment in patients with peritoneal carcinomatosis is often limited by the extent of small bowel involvement. We investigated the results of the application of cold-plasma coagulation on the surface of the small bowel.",
"After permission by the federal government of Schleswig-Holstein, 8 female pigs ... | The application of cold-plasma coagulation on the surface of vital bowel in pigs is safe. We would recommend against the use of the highest energy level of 100 W before more clinical data are available. | yes |
23076781 | Are overweight and obesity associated with improved survival , functional outcome , and stroke recurrence after acute stroke or transient ischaemic attack : observations from the TEMPiS trial? | [
"The aim of the study was to evaluate the association of the body mass index (BMI) with mortality and with non-fatal functional outcome in patients with acute stroke or transient ischaemic attack (TIA). Obesity is an established risk factors in primary cardiovascular disease prevention including stroke. The impact ... | Overweight and obese patients with stroke or TIA have better survival and better combined outcomes of survival and non-fatal functional status than patients with the BMI <25 kg/m(2). | yes |
25651743 | Does prostaglandin F2 alpha plasma concentration predict glycemic control and oxidation status in patients with type 2 diabetes mellitus? | [
"8-iso-PGF2α is a family of PGF2α that could be offered as a non-invasive tool to represent in vivo oxidation status, as a link between oxidative milieus and vascular dysfunction.",
"A total of 45 patients with type 2 diabetes and 45 healthy adults were studied in this cross-sectional analysis. Blood samples were... | Our study provides evidence for the application of serum 8-isoPGF2α in the 25 - 75% quartile ranges to screen for the severity of oxidative reactions and glycemic control in vivo without need for any further in vitro enzymatic reactions, with higher levels, reflecting more severe oxidation and poor glycemic control. | yes |
24201141 | Does feeding on prey increase photosynthetic efficiency in the carnivorous sundew Drosera capensis? | [
"BACKROUND AND AIMS: It has been suggested that the rate of net photosynthesis (AN) of carnivorous plants increases in response to prey capture and nutrient uptake; however, data confirming the benefit from carnivory in terms of increased AN are scarce and unclear. The principal aim of our study was to investigate ... | According to the stoichiometric relationships among different nutrients, the growth of unfed D. capensis plants was P-limited. This P-limitation was markedly alleviated by feeding on fruit flies and resulted in improved plant nutrient status and photosynthetic performance. This study supports the original cost/benefit ... | yes |
16352685 | Is the association of CTLA4 polymorphism with type 1 diabetes concentrated in patients complicated with autoimmune thyroid disease : a multicenter collaborative study in Japan? | [
"Transracial studies are a powerful tool for genetic association studies of multifactorial diseases, such as type 1 diabetes. The low incidence of type 1 diabetes in Asian countries, however, makes it difficult to perform large-scale studies in Asia.",
"To overcome this, we have assembled a multicenter study grou... | Given the high frequency of AITD in patients with type 1 diabetes, these data suggest the possibility that the association of CTLA4 with type 1 diabetes in previous studies may have been secondary to AITD, suggesting the importance of subclassification of type 1 diabetes relative to AITD in genetic studies. | yes |
18073591 | Does early hyperglycemia predict multiple organ failure and mortality but not infection? | [
"Previous studies attempting to characterize the association between early hyperglycemia (EH) and subsequent outcome have been performed without utilization of a strict glycemic control protocol. We sought to characterize the clinical outcomes associated with EH in a cohort of severely injured trauma patients, when... | These results suggest that EH is a marker of severe physiologic insult after injury, and that strict glycemic control may reduce or prevent the infectious complications previously shown to be associated with hyperglycemia early after injury. | yes |
25605664 | Does cardiometabolic Profile Related to Body Adiposity identify Patients Eligible for Bariatric Surgery More Accurately than BMI? | [
"Eligibility criteria for bariatric surgery (BS) are based on BMI and the presence of major comorbidities. Our aim was to analyze the usefulness of body adiposity determination in establishing the indication for BS.",
"In order to analyze the cardiometabolic risk according to eligibility criteria for BS, four gro... | The present study provides evidence for the existence of an adverse cardiometabolic profile in subjects currently considered to be outside traditional NIH guidelines but exhibiting a highly increased adiposity. It is concluded that body composition analysis yields valuable information to be incorporated into indication... | yes |
22718278 | Is a novel germline mutation in HOXB13 associated with prostate cancer risk in Chinese men? | [
"A rare mutation G84E in HOXB13 was recently identified to be associated with prostate cancer (PCa) in Caucasians. The goal of this study is to test association between HOXB13 genetic variants and PCa risk in Chinese men.",
"All study subjects were part of the Chinese Consortium for Prostate Cancer Genetics (Chin... | We identified a novel rare mutation in the HOXB13 gene, G135E, which appears to be a founder mutation. This mutation is associated with increased PCa risk in Chinese men. Consistent with a previous report, our findings provide further evidence that rare mutations in HOXB13 contribute to PCa risk. | yes |
26925879 | Does cognitive Impairment predict The Occurrence Of Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt? | [
"Hepatic encephalopathy (HE) is a major problem in patients treated with TIPS. The aim of the study was to establish whether pre-TIPS covert HE is an independent risk factor for the development of HE after TIPS.",
"Eighty-two consecutive cirrhotic patients submitted to TIPS were included. All patients underwent t... | Psychometric evaluation before TIPS is able to identify most of the patients who will develop HE after a TIPS and can be used to select patients in order to have the lowest incidence of this important complication. | yes |
20440060 | Do schistosoma mansoni soluble egg antigens enhance HCV replication in mammalian cells? | [
"This work demonstrates successful propagation of HCV in HepG2 and human blood cells as well as viral shedding into their culture media. The influence of Schistosoma mansoni crude soluble egg antigens (SEA) on the rate of viral propagation in both mammalian cells was also monitored.",
"HepG2 cells were inoculated... | HepG2 cells as well as whole blood cultures maintain HCV replication. Furthermore, SEA has the potential to enhance HCV propagation. | yes |
24895163 | Does postextrasystolic blood pressure potentiation predict poor outcome of cardiac patients? | [
"Postextrasystolic blood pressure potentiation (PESP), the pulse wave augmentation after an extrasystolic beat, is typically enhanced in heart failure (HF) patients. This study prospectively tested the association of PESP and mortality in cardiac patients.",
"Consecutive patients (n=941; mean age, 61 years; 19% f... | PESP, which likely reflects abnormalities of myocardial calcium cycling, predicts the mortality risk in postinfarction patients. | yes |
22969190 | Does use of butyrate or glutamine in enema solution reduce inflammation and fibrosis in experimental diversion colitis? | [
"To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.",
"Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine, butyrate, or saline. Enemas were administered twice a week in the exc... | The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | yes |
19178984 | Does neuroselective transcutaneous electrical stimulation reveal neuronal sensitization in atopic dermatitis? | [
"The neuroselective transcutaneous electrical stimulator (NTES) can provoke itch and/or pain by the application of a 5-Hz alternating current.",
"We sought to examine whether there is any difference in the perception of the stimulus evoked by the NTES between patients with atopic dermatitis (AD) and healthy contr... | Tests were performed on limited body areas. | yes |
23428589 | Does fasting serum concentration of apolipoprotein B48 represent residual risks in patients with new-onset and chronic coronary artery disease? | [
"To identify new therapeutic targets for coronary artery disease (CAD), we investigated whether fasting serum concentration of apolipoprotein (apo) B48 could be a marker for CAD.",
"Patients with CAD were divided into those with new-onset CAD [i.e., those receiving percutaneous coronary intervention (PCI) for the... | Fasting serum apoB48 concentration could be a marker of new onset as well as chronic CAD, and predict new lesion progression in secondary prevention. | yes |
21745194 | Does cAMP signalling protect proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac? | [
"Nephrotoxicity is the principal dose-limiting factor for cisplatin chemotherapy and is primarily associated with proximal tubular epithelial cells, including disruption of cell adhesions and induction of apoptosis. Cell adhesion and survival is regulated by, amongst other factors, the small GTPase Rap and its acti... | Our study identifies activation of Epac-Rap signalling as a potential strategy for reducing the nephrotoxicity associated with cisplatin treatments and, as a result, broadens the therapeutic window of this chemotherapeutic agent. | yes |
19402860 | Do they just do n't get enough ! Variable intern experience in bedside procedural skills? | [
"Medical school and resident training programmes offer different learning opportunities and outcomes. The aim of the study was to assess medical student and intern experience in common clinical procedures.",
"Interns employed in a metropolitan teaching hospital from 2000 to 2004 completed a survey of experience a... | Interns and students receive variable experience to carry out procedural skills on patients. This makes designing training programmes difficult as training needs vary each year. Both mandatory supervision of key skills and opportunities to supplement limited experience are needed during the intern year to ensure a unif... | yes |
25976932 | Does small heterodimer partner attenuate profibrogenic features of hepatitis C virus-infected cells? | [
"An atypical orphan nuclear receptor small heterodimer partner (SHP) is known to be regulated by AMP-activated protein kinase (AMPK). Both of them inhibit TGF-β and Smad signalling and exhibit antifibrotic activity in the liver. However, little is known about the protective effects of SHP and AMPK against hepatitis... | These results demonstrate that overexpression of SHP and activation of AMPK reverses profibrogenic features of HCV-infected cells by decreasing TGF-β and fibrotic gene expression. These findings provide a rationale for SHP as a possible therapeutic target against HCV-induced hepatic fibrosis. | yes |
24673486 | Does erythropoietin attenuate oxidative stress and apoptosis in Schwann cells isolated from streptozotocin-induced diabetic rats? | [
"High glucose-evoked oxidative stress and apoptosis within Schwann cells (SCs) are mechanisms facilitating the procession of diabetic peripheral neuropathy (DPN). Although erythropoietin (EPO) was demonstrated to have neuroprotective effects in neurodegenerative diseases, the effects of EPO on glucose-evoked oxidat... | The data of this study offered fresh viewpoints for interpreting the pathogenesis of DPN and novel pharmacological principles implicit in the therapeutic effect of EPO. | yes |
19576647 | Does endoglin haploinsufficiency reduce radiation-induced fibrosis and telangiectasia formation in mouse kidneys? | [
"Endoglin is a transforming growth factor beta (TGF-beta) co-receptor mainly expressed in dividing endothelial cells. It regulates cell proliferation and survival and is upregulated at sites of vessel repair. Mutations in endoglin have been linked to the vascular disease hereditary hemorrhagic telangiectasia (HHT).... | Endoglin plays an important role in the development of irradiation-induced normal tissue damage. Future studies will show whether interfering with endoglin functions protects tissues from late radiation toxicity. | yes |
16282333 | Does implementation of a new policy result in a decrease of pressure ulcer frequency? | [
"To determine the effects of a new policy on the efficiency of pressure ulcer care.",
"Series of 1-day pressure ulcer surveys before and after the implementation.",
"A 900-bed University Medical Centre in The Netherlands.",
"On the days of the surveys, 657 patients were included before the implementation, 735... | The number of pressure ulcer patients in hospital can successfully be reduced. General measures such as the introduction of adequate mattresses and guidelines for prevention and treatment are promising tools in this respect. | yes |
22878917 | Do not all side population cells contain cancer stem-like cells in human gastric cancer cell lines? | [
"Side population (SP) cells may play a crucial role in tumorigenesis and the recurrence of cancer. Many kinds of cell lines and tissue have demonstrated presence of SP cells including different gastric cancer cell lines. However, is that true all SP cells contain cancer stem-like cells in gastric cancer cell lines?... | SP cells from MKN-45 possess cancer stem cell properties and proved that they were gastric cancer stem-like cells. SP cells from BGC-823 didn't possess cancer stem cell properties and proved that not all SP cells contain cancer stem-like cells in gastric cancer cell lines. | yes |
24856512 | Are cardiac molecular markers of programmed cell death activated in end-stage heart failure patients supported by left ventricular assist device? | [
"Cardiomyocyte apoptosis increases in heart failure (HF) and is implicated in disease progression. The apoptotic cell is not inevitably committed to death, and appropriate therapy like left ventricular assist device (LVAD) support could offer a rescue of cellular functions. Literature data regarding the modulation ... | LVAD appears to induce an activation of apoptotic mediators, mainly at the mitochondrial level, while the following activation of Casp-3 is reduced by the significant increase of Hsp72, whose enhancement could be an important factor in cardiac remodeling associated with LVAD support. | yes |
22035293 | Does ultrasound microbubble-mediated delivery of the siRNAs targeting MDR1 reduce drug resistance of yolk sac carcinoma L2 cells? | [
"MDR1 gene encoding P-glycoprotein is an ATP-dependent drug efflux transporter and related to drug resistance of yolk sac carcinoma. Ultrasound microbubble-mediated delivery has been used as a novel and effective gene delivery method. We hypothesize that small interfering RNA (siRNA) targeting MDR1 gene (siMDR1) de... | Our results demonstrated that ultrasound microbubble-mediated delivery of MDR1 siRNA was safe and effective in L2-RYC cells. MDR1 silencing led to decreased P-glycoprotein activity and drug resistance of L2-RYC cells, which may be explored as a novel approach of combined gene and chemotherapy for yolk sac carcinoma. | yes |
22941511 | Does complement activation contribute to the injury and outcome of kidney in human anti-glomerular basement membrane disease? | [
"Linear or granular deposition of complement 3 (C3) along glomerular basement membrane (GBM) is generally revealed in kidneys of human anti-GBM disease. However, the mechanism of complement activation and its association with clinical features and outcomes are less clear.",
"We measured the plasma and urinary lev... | Complement cascade goes to the end in human anti-GBM disease and resides mainly in kidney. It plays pathogenic role in renal injury, by the possible proinflammatory effect of C5a and/or cell lysis effect of C5b-9. C5a and C5b-9 may be useful in clinical monitoring and predicting. | yes |
21143371 | Does succinate independently stimulate full platelet activation via cAMP and phosphoinositide 3-kinase-β signaling? | [
"The citric cycle intermediate succinate has recently been identified as a ligand for the G-protein-coupled receptor (GPCR) SUCNR1. We have previously found that this receptor is one of the most highly expressed GPCRs in human platelets.",
"The aim of this study was to investigate the role of SUCNR1 in platelet a... | Our experiments show that succinate induces full aggregation of human platelets via SUCNR1. Succinate-induced platelet aggregation depends on thromboxane A(2) generation, ATP release, and P2Y(12) activation. | yes |
23400250 | Does dextromethorphan inhibit osteoclast differentiation by suppressing RANKL-induced nuclear factor-κB activation? | [
"Dextromethorphan (DXM), a commonly used antitussive, is a dextrorotatory morphinan. Here, we report that DXM inhibits the receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastogenesis and bone resorption by abrogating the activation of NF-κB signalling in vitro. Oral administration of DXM ... | DXM inhibits osteoclast differentiation and activity by affecting NF-κB signaling. Therefore, DXM at suitable doses may have new therapeutic applications for the treatment of diseases associated with excessive osteoclastic activity. | yes |
20498795 | Is cardioprotection by kappa-opioid receptor agonist U50488H mediated by opioidergic regulation but not by calcium current modulation? | [
"Because the kappa-opioid receptor (OR) agonist U50488H stimulates opioidergic regulation and inhibits L-type Ca(2+) channels, this study was aimed at assessing the roles of OR and L-type Ca(2+) channels on U50488H-induced cardioprotection.",
"Langendorff-perfused rat hearts were subjected to 30 min of regional i... | U50488H significantly limits myocardial infarction and stunning in isolated rat hearts after ischemia-reperfusion induction. The infarct size limitation and contractility improvement observed with U50488H treatment during reperfusion are entirely mediated by OR stimulation and not by Ca(2+) channel modulation. | yes |
22121941 | Do mothers report more child-rearing disagreements following early brain injury than do fathers? | [
"To investigate differences between mother's and father's perceptions of marital relationship quality, child rearing disagreements, and family functioning over the initial 18 months following traumatic brain injury (TBI) in early childhood relative to an orthopedic-injury comparison group.",
"Participants include... | Implications for treatment based on differences in mothers' and fathers' perceptions of family and marital functioning, and future directions for research, are discussed. | yes |
15480168 | Is outcome of renal transplantation in South Asian recipients similar to that in non-Asians? | [
"The United Kingdom has a large South Asian population, in which there is a high rate of renal disease and which forms a significant percentage of the renal transplant waiting list. Information about short- and long-term transplant outcomes in this ethnic group is limited, although it has been suggested that graft ... | In this cohort of patients, South Asian ethnic background did not confer a survival disadvantage after renal transplantation. | yes |
25453614 | Does progressive demyelinating neuropathy correlate with clinical severity in Cockayne syndrome? | [
"Cockayne syndrome (CS) is characterized by postnatal growth failure and progressive multi-organ dysfunctions. CSA and CSB gene mutations account for the majority of cases and three degrees of severity are delineated. A peripheral neuropathy is known to be associated with CS but the type, severity and correlation o... | CS is associated with a progressive sensory and motor neuropathy. Signs of segmental demyelination, including conduction blocks, may not be obvious before the age of 2years. CV slowing is correlated with the CS clinical severity. | yes |
15452377 | Is translocation t ( 11 ; 18 ) ( q21 ; q21 ) predictive of response to chemotherapy with 2CdA in patients with gastric MALT lymphoma? | [
"t(11;18)(q21;q21) resulting in the API2-MALT1 fusion transcript is an exclusive finding in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). While it has recently been demonstrated as a negative predictor for gastric MALT lymphoma undergoing eradication of Helicobacter ... | Our findings suggest that the presence of the API2-MALT1 fusion transcript resulting from t(11;18)(q21;q21) does not adversely affect the response of gastric MALT lymphoma to chemotherapy with 2CdA. 2CdA appears to be an attractive agent for treatment of gastric MALT lymphoma unresponsive to H. pylori eradication, incl... | no |
18727829 | Does dorsal turning of motor corticospinal axons at the pyramidal decussation require plexin signaling? | [
"The development of the corticospinal tract (CST) in higher vertebrates relies on a series of axon guidance decisions along its long projection pathway. Several guidance molecules are known to be involved at various decision points to regulate the projection of CST axons. However, previous analyses of the CST guida... | Dorsal turning and midline crossing at the pyramidal decussation is a crucial step to properly direct CST axons into the dorsal spinal cord. We show that the signaling of plexin-A3, plexin-A4, and Sema6A is at least partially required for dorsal turning of the CST axons, while neuropilin-1 is required for proper fascic... | yes |
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