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ccda3255747c397861de7735c0472073 | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | Characterizing and controlling the inflammatory network during influenza A virus infection. To gain insights into the pathogenesis of influenza A virus (IAV) infections, this study focused on characterizing the inflammatory network and identifying key proteins by combining high-throughput data and computational techniq... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | 0y80k5kw | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
c3d7cbe3809a5ea4bfddeaec9f075891 | mteb/scifact | Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway. | Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance. Activating mutations in genes encoding G protein α (Gα) subunits occur in 4-5% of all human cancers, but oncogenic alterations in Gβ subunits have not been defined. Here we demonstrate that recurrent mutations in the Gβ protein... | [
"Gq protein alpha subunits Galphaq and Galpha11 are localized at postsynaptic extra-junctional membrane of cerebellar Purkinje cells and hippocampal pyramidal cells.. Following cell surface receptor activation, the alpha subunit of the Gq subclass of GTP-binding proteins activates the phosphoinositide signalling pa... | 813 | 33387953 | [
"13411519",
"1044552",
"11200685",
"39929509"
] | scientific_claim_retrieval | scientific |
1a7a78a05bbdde2379f268b0eca6367c | mteb/scifact | Medications to treat obesity have unwanted side effects. | Long term pharmacotherapy for obesity and overweight: updated meta-analysis.. OBJECTIVE To summarise the long term efficacy of anti-obesity drugs in reducing weight and improving health status. DESIGN Updated meta-analysis of randomised trials. DATA SOURCES Medline, Embase, the Cochrane controlled trials register, the ... | [
"Adverse drug events: database construction and in silico prediction.. Adverse drug events (ADEs) are the harms associated with uses of given medications at normal dosages, which are crucial for a drug to be approved in clinical use or continue to stay on the market. Many ADEs are not identified in trials until the... | 766 | 7552215 | [
"583260",
"5839365",
"22534357",
"37336085"
] | scientific_claim_retrieval | scientific |
fd05683ccaad4eed72b73029c7eafcb9 | mteb/scifact | Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors. | Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation. DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that duplicate megabase-sized chromosome segments at specific times during S-phase. Cytogenetic studies show that these "replicon clusters" ... | [
"Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.. Induced pluripotent stem cells (iPSCs) can be derived from somatic cells by gene transfer of reprogramming transcription factors. Expression levels of these factors strongly influence the overall efficacy to f... | 1342 | 8148122 | [
"24512417",
"24307695",
"18037805",
"4455466"
] | scientific_claim_retrieval | scientific |
b766b6edb24515d711deb32caa97aaaa | mteb/scifact | IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs. | A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.. The cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to most RNA viruses by detecting viral 5'-triphosphorylated RNA (pppRNA). Although endogenous mRNA is also 5'-triphosphorylated... | [
"MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA. beta-Cell destruction in type 1 diabetes (T1D) is at least in part consequence of a 'dialog' between beta-cells and immune system. This dialog may be affected by the individual's... | 545 | 24221369 | [
"16058322",
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] | scientific_claim_retrieval | scientific |
36c3e47b7c0d023bc9b84d66818a21a0 | mteb/scifact | Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA. | Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune complexes (RNP ... | [
"Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies.. Mitochondria play a pivotal role in energy metabolism, programmed cell death and oxidative stress. Mutated mitochondrial DNA in diseased cells compromises the structure of key enzyme complexes and, therefore, mitoc... | 557 | 1049501 | [
"20456030",
"12641252",
"1522647",
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] | scientific_claim_retrieval | scientific |
80c2281fbb809f8e679c10c8b55f3705 | mteb/scifact | Cognitive behavioral therapy is an ineffective treatment for insomnia | A clinical approach to circadian rhythm sleep disorders.. Circadian rhythm sleep disorders are characterized by complaints of insomnia and excessive sleepiness that are primarily due to alterations in the internal circadian timing system or a misalignment between the timing of sleep and the 24-h social and physical env... | [
"Gene therapy of arthritis with TCR isolated from the inflamed paw.. In recent years, the treatment of autoimmune diseases has been significantly advanced by the use of biological agents. However, some biologics are accompanied with severe side effects, including tuberculosis and other types of infection. There is ... | 267 | 31554917 | [
"14834714",
"16787954",
"27127885",
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] | scientific_claim_retrieval | scientific |
7d9b18363bd295a25a6c690640ef17f1 | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Could Environment Affect the Mutation of H1N1 Influenza Virus?. H1N1 subtype influenza A viruses are the most common type of influenza A virus to infect humans. The two major outbreaks of the virus in 1918 and 2009 had a great impact both on human health and social development. Though data on their complete genome sequ... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | rb8g5llp | [
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] | biomedical_literature_retrieval | scientific |
2701f2a0bf99ad501ee113c18e5565c9 | mteb/scifact | Pro-inflammatory cytokines are up regulated during tumor development. | Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.. Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions bet... | [
"Gene expression during gonadogenesis in the chicken embryo.. Genes implicated in vertebrate sex determination and differentiation were studied in embryonic chicken gonads using reverse transcription and the polymerase chain reaction (RT-PCR). Expression profiles were obtained during gonadal sex differentiation for... | 977 | 14075252 | [
"28390999",
"43619625",
"13231899",
"40343416"
] | scientific_claim_retrieval | scientific |
3866eb5cf7546789eeb177c6e5753848 | mteb/scifact | In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes. | Carvedilol for children and adolescents with heart failure: a randomized controlled trial.. CONTEXT Although beta-blockers improve symptoms and survival in adults with heart failure, little is known about these medications in children and adolescents. OBJECTIVE To prospectively evaluate the effects of carvedilol in chi... | [
"Heart failure admissions in adults with congenital heart disease; risk factors and prognosis.. BACKGROUND Heart failure (HF) is a serious complication and often the cause of death in adults with congenital heart disease (CHD). Therefore, our aims were to determine the frequency of HF-admissions, and to assess risk... | 579 | 34139429 | [
"24408040",
"16511863",
"5993745",
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] | scientific_claim_retrieval | scientific |
073c180db09131ecaf47670033f26147 | mteb/scifact | Monoclonal antibody targeting of N-cadherin encourages castration resistance. | Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance. The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing gene expression in isogenic androgen-dependent and CRPC xe... | [
"Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape. Neutralizing antibodies are likely to play a crucial part in a preventative HIV-1 vaccine. Although efforts to elicit broadly cross-neutralizing (BCN) antibodies by vaccination have been unsuccessful, a minority of in... | 801 | 22180793 | [
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] | scientific_claim_retrieval | scientific |
8edbb05303ee89c30d97266e7eb4c6f9 | mteb/scifact | Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min. | Single-RNA counting reveals alternative modes of gene expression in yeast. Proper execution of transcriptional programs is a key requirement of gene expression regulation, demanding accurate control of timing and amplitude. How precisely the transcription machinery fulfills this task is not known. Using an in situ hybr... | [
"Association of Intracerebral Hemorrhage Among Patients Taking Non–Vitamin K Antagonist vs Vitamin K Antagonist Oral Anticoagulants With In-Hospital Mortality. Importance Although non–vitamin K antagonist oral anticoagulants (NOACs) are increasingly used to prevent thromboembolic disease, there are limited data on ... | 1314 | 16237005 | [
"3898784",
"18537148",
"1495563",
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] | scientific_claim_retrieval | scientific |
600c745ff19674ea64fd1f519dd45f12 | mteb/scifact | 0-dimensional biomaterials lack inductive properties. | New opportunities: the use of nanotechnologies to manipulate and track stem cells.. Nanotechnologies are emerging platforms that could be useful in measuring, understanding, and manipulating stem cells. Examples include magnetic nanoparticles and quantum dots for stem cell labeling and in vivo tracking; nanoparticles, ... | [
"Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.. Extensive evidence implicates activation of the lipid phosphatidylinositide 3-kinase (PI3K) pathway in the genesis and progression of various human cancers. PI3K inhibitors thus have considerable potential as molecula... | 0 | 31715818 | [
"1285713",
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] | scientific_claim_retrieval | scientific |
8c8d54ac5ae9043ee7c7260d53fc1c88 | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | Selectins and Associated Adhesion Proteins in Inflammatory disorders. Inflammation is defined as the normal response of living tissue to injury or infection. It is important to emphasize two components of this definition. First, that inflammation is a normal response and, as such, is expected to occur when tissue is da... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | pt27efu1 | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
b90c3b7efb61c3a14dec4823930e64a3 | mteb/scifact | Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production. | Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation. Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic cancer progression. MDSC regulation is widely variable even among patients harbouring the same type of malignancy, and the mechanisms gov... | [
"Tissue-specific alterations in the glucocorticoid sensitivity of immune cells following repeated social defeat in mice. Endogenous glucocorticoids (GC) play an important role in the termination of the inflammatory response following infection and tissue injury. However, recent findings indicate that stress can imp... | 223 | 2014909 | [
"44562221",
"8764879",
"19510470",
"5774746"
] | scientific_claim_retrieval | scientific |
5a6c8bab56e8f3ff870942f9e5eee23e | mteb/trec-covid | are there serological tests that detect antibodies to coronavirus? | Double-Edged Spike: Are SARS-CoV-2 Serologic Tests Safe Right Now? | [
"Estimating human-to-human transmissibility of hepatitis A virus in an outbreak at an elementary school in China, 2011. Hepatitis A is caused by hepatitis A virus and occurs worldwide. Estimating the transmissibility, which is usually characterized by the basic reproductive number R(0), the mean number of secondary... | 7 | ka1vm9f2 | [
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] | biomedical_literature_retrieval | scientific |
87698aa7752ed9201286254a6f9eb1f4 | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | Ebola Preparedness: On Avoiding Making a Scary Virus Scarier | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | ss8x75fr | [
"gqa526yl",
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6b16cdd48bf440627c97009330445e4a | mteb/scifact | Ribosomopathies have a high degree of cell and tissue specific pathology. | Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning. Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather than regulatory capacity in mRNA translation. Here we identify mutations of the Ribosomal Protein L38 (Rpl38) gene in mice exhibiting surprisi... | [
"Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family.. We have identified and characterized the gene for a novel zinc finger transcription factor which we have termed lung Krüppel-like factor (LKLF). LKLF was isolated th... | 1048 | 12486491 | [
"21108759",
"27686445",
"28230867",
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] | scientific_claim_retrieval | scientific |
b23a7f76639b315c3aaf3e1e02825b90 | mteb/scifact | Amitriptyline is an effective treatment for chronic tension-type headaches. | Management of chronic tension-type headache with tricyclic antidepressant medication, stress management therapy, and their combination: a randomized controlled trial.. CONTEXT Chronic tension-type headaches are characterized by near-daily headaches and often are difficult to manage in primary practice. Behavioral and p... | [
"Development of leukemia in donor cells after allogeneic stem cell transplantation--a survey of the European Group for Blood and Marrow Transplantation (EBMT).. Leukemia in donor cells (donor cell leukemia; DCL) has been reported as a rare but severe complication of allogeneic stem cell transplantation (SCT). Howev... | 108 | 6191684 | [
"11344428",
"3308636",
"44030361",
"24510595"
] | scientific_claim_retrieval | scientific |
6edf6685bc78dc1b9e5d977afb97dbfc | mteb/scifact | LSD1-positive promoters are associated with RNA polymerase II | Histone Methylation-Dependent Mechanisms Impose Ligand Dependency for Gene Activation by Nuclear Receptors. Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actual requirement for specific epigenetic landmarks to impose lig... | [
"Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling.. The yeast histone variant H2AZ (Htz1) is implicated in transcription activation, prevention of the ectopic spread of heterochromatin, and genome integrity. Our genome-wide localiza... | 679 | 13639330 | [
"18694784",
"14380875",
"4411760",
"22623275"
] | scientific_claim_retrieval | scientific |
8582981f2d5b83b83bdc61b922805038 | mteb/scifact | Aged patients are less susceptible to ischaemia/reperfusion injury. | Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Chaperone-mediated autophagy (CMA), a selective mechanism for degradation of cytosolic proteins in lysosomes, contributes to the removal of altered proteins as part of the cellular quality-control systems. We ... | [
"Cancer treatment and survivorship statistics, 2014.. The number of cancer survivors continues to increase due to the aging and growth of the population and improvements in early detection and treatment. In order for the public health community to better serve these survivors, the American Cancer Society and the Na... | 91 | 1084345 | [
"25121903",
"13000926",
"1905095",
"27466734"
] | scientific_claim_retrieval | scientific |
18214cd2df1c5bdd6945c7bb41740757 | mteb/scifact | Expression of oncolytic virus antigens as peptides makes relapse more likely. | Detecting and targeting tumor relapse by its resistance to innate effectors at early recurrence. Tumor recurrence represents a major clinical challenge. Our data show that emergent recurrent tumors acquire a phenotype radically different from that of their originating primary tumors. This phenotype allows them to evade... | [
"Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10.. Virally infected cells degrade intracellular viral proteins proteolytically and present the resulting peptides in association with major histocompatibility complex (MHC) class I molecules to CD8+ cytotoxic T lymphoc... | 403 | 1921218 | [
"18938992",
"25994317",
"85693958",
"26108767"
] | scientific_claim_retrieval | scientific |
cb18ba5c33650cd3697aa18828c74650 | mteb/scifact | Pro-inflammatory cytokines are up regulated during tumor development. | Impact of TNF-alpha and IL-6 levels on development of cachexia in newly diagnosed NSCLC patients.. OBJECTIVES We investigated the role of cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in cachexia development in newly diagnosed nonsmall cell lung cancer (NSCLC) patients. METHODS : We evaluat... | [
"Gene expression during gonadogenesis in the chicken embryo.. Genes implicated in vertebrate sex determination and differentiation were studied in embryonic chicken gonads using reverse transcription and the polymerase chain reaction (RT-PCR). Expression profiles were obtained during gonadal sex differentiation for... | 977 | 39264456 | [
"28390999",
"43619625",
"13231899",
"40343416"
] | scientific_claim_retrieval | scientific |
dfe1bee2fa536722dac5c5b7a0e0454e | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | Protecting Medical Trainees on the Coronavirus Disease 2019 (COVID-19) Frontlines Saves Us All | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | q3mfoiu2 | [
"5bwsb265",
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"jk7cn1p3",
"pyrfgggz"
] | biomedical_literature_retrieval | scientific |
ff5a7771eee95cbcf315c9a9380348a9 | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | Understanding the Impact of Face Mask Usage Through Epidemic Simulation of Large Social Networks. Evidence from the 2003 SARS epidemic and 2009 H1N1 pandemic shows that face masks can be an effective non-pharmaceutical intervention in minimizing the spread of airborne viruses. Recent studies have shown that using face ... | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | 14x4uqq7 | [
"5bwsb265",
"3okytwd8",
"jk7cn1p3",
"pyrfgggz"
] | biomedical_literature_retrieval | scientific |
d313682a83651792e1a0407bfc1a3c7a | mteb/scifact | Men are more susceptible to death due to pneumonia when compared to women. | Gender-dependent differences in outcome after the treatment of infection in hospitalized patients.. CONTEXT While it is established that management strategies and outcomes differ by gender for many diseases, its effect on infection has not been adequately studied. OBJECTIVE To investigate the role of gender among hospi... | [
"Pathology of postprimary tuberculosis in humans and mice: contradiction of long-held beliefs.. Tuberculosis remains one of the world's leading infectious causes of death. Approximately 80% of all disease is due to postprimary (secondary) tuberculosis in the lung. Unfortunately, tissues of developing lesions are se... | 767 | 2488880 | [
"33835579",
"23785605",
"19368793",
"29253460"
] | scientific_claim_retrieval | scientific |
39484237da4223fc6722b0bcb5c92c26 | mteb/scifact | A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population. | Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age. Importance Despite lack of evidence of their utility, biomarkers of ovarian reserve are being promoted as potential markers of reproductive potential. Objective To determine the associations between biomarkers of ov... | [
"Diminished performance on neuropsychological testing in late life depression is correlated with microstructural white matter abnormalities.. BACKGROUND Traditional T2 weighted MR imaging results are non-specific for the extent of underlying white matter structural abnormalities present in late life depression (LLD... | 39 | 13497630 | [
"1412089",
"42150015",
"30919024",
"11415809"
] | scientific_claim_retrieval | scientific |
85fcb08f50a5566a3d38e82be81a9925 | mteb/trec-covid | how long can the coronavirus live outside the body | Factors Involved in Aerosol Transmission of Infection and Control of Ventilation in Healthcare. Experience with the recent viral pandemics has generated a renewed interest in the study of the transmission modes of respiratory pathogens. It not only provides better understanding of the pathogenesis of the disease but al... | [
"The impact of respiratory viruses on lung health after preterm birth. Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased... | 15 | xm4fmqoo | [
"am4mdxok",
"dxdr6oan",
"49it5pha",
"mw7athol"
] | biomedical_literature_retrieval | scientific |
c237e2ce073a55bfac65057f8a45fbf3 | mteb/scifact | Activation of PPM1D enhances p53 function. | Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Improved sequencing technologies offer unprecedented opportunities for investigating the role of rare genetic variation in common disease. However, there are considerable challenges with respect to study design, data analysis and re... | [
"The inflammasome component NLRP3 impairs antitumor vaccine by enhancing the accumulation of tumor-associated myeloid-derived suppressor cells.. The inflammasome is a proteolysis complex that generates the active forms of the proinflammatory cytokines interleukin (IL)-1β and IL-18. Inflammasome activation is mediat... | 69 | 4414547 | [
"15435343",
"23912923",
"21295300",
"23700330"
] | scientific_claim_retrieval | scientific |
922edc8961e60fa0327c67d0224347c7 | mteb/scifact | Bariatric surgery reduces colorectal cancer. | Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.. BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in large... | [
"Brief, four-session group CBT reduces binge eating behaviors among bariatric surgery candidates.. BACKGROUND The objective of this study was to evaluate the effectiveness of a brief, 4-session cognitive behavioral, group psychotherapy for binge eating among bariatric surgery candidates at an academic medical cente... | 168 | 5824985 | [
"7627167",
"24980622",
"8037453",
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] | scientific_claim_retrieval | scientific |
c4d5d9feaaf4fa07091a658a273e8f93 | mteb/scifact | Side effects associated with antidepressants increases risk of stroke. | Antidepressant use and risk of adverse outcomes in older people: population based cohort study. OBJECTIVES To investigate the association between antidepressant treatment and risk of several potential adverse outcomes in older people with depression and to examine risks by class of antidepressant, duration of use, and ... | [
"Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. BACKGROUND The MTHFR 677C→T polymorphism has been associated with raised homocysteine concentration and increased risk of stroke. A pr... | 1084 | 5691302 | [
"8595678",
"5107861",
"28910120",
"37424881"
] | scientific_claim_retrieval | scientific |
75950dda69e58b47f97fbf7b59301a69 | mteb/trec-covid | what kinds of complications related to COVID-19 are associated with hypertension? | Pulmonary Vascular Disease. The pulmonary vasculature is an anatomic compartment that is frequently overlooked in the histologic review of lung biopsy samples, other than those obtained specifically to assess pulmonary vascular disease.1 Though often of a nonspecific nature, the histologic pattern of vascular remodelin... | [
"Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques. The experimental infection of rhesus macaques (rh) with simian immunodeficiency virus (SIV) is an important model for human immunodeficiency virus (HIV) infection of humans. The interferon-induced transmembrane protein 3 (IFIT... | 23 | 159p181f | [
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2ec9c3d72a3ade5f35b231b9f69dfca8 | mteb/scifact | Forkhead 0 (fox0) transcription factors are involved in cellular differentiation. | Cell Stem Cell Review FoxO Transcription Factors and Stem Cell Homeostasis: Insights from the Hematopoietic System. The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism... | [
"Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers.. Transcription factors (TFs) bind specifically to discrete regions of mammalian genomes called cis-regulatory elements. Among those are enhancers, which play key roles in regulation of gene expression during development and diffe... | 428 | 16728949 | [
"2151983",
"4303075",
"13798951",
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] | scientific_claim_retrieval | scientific |
97509d2f5d974af23bd61e110d362480 | mteb/scifact | Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells. | Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells. Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead to synchronization. Here, we estimated the mutual interaction... | [
"Circadian Clocks in Human Red Blood Cells. Circadian (∼24 hour) clocks are fundamentally important for coordinated physiology in organisms as diverse as cyanobacteria and humans. All current models of the molecular circadian clockwork in eukaryotic cells are based on transcription-translation feedback loops. Non-t... | 242 | 2212067 | [
"4385779",
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"23918031"
] | scientific_claim_retrieval | scientific |
793bc7244e7137deac2967d03d1933fc | mteb/scifact | Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels. | Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli. Gram-negative bacteria have an outer membrane (OM) that functions as a barrier to protect the cell from toxic compounds such as antibiotics and detergents. The OM is a highly asymmetric bilayer composed of phospholipi... | [
"A Microtubule Interactome: Complexes with Roles in Cell Cycle and Mitosis. The microtubule (MT) cytoskeleton is required for many aspects of cell function, including the transport of intracellular materials, the maintenance of cell polarity, and the regulation of mitosis. These functions are coordinated by MT-asso... | 1032 | 6836086 | [
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ee016d1122860529b9849516885a12ab | mteb/trec-covid | what type of hand sanitizer is needed to destroy Covid-19? | Viscosity is an important factor of resistance to alcohol-based disinfectants by pathogens present in mucus. Alcohol-based disinfectants play an important role in the prevention of healthcare-acquired infection (HAI). We investigated whether pathogens present in mucus acquire resistance to alcohol-based disinfectants, ... | [
"Airspace-Occupying Diseases. Diseases of the air space of the lung share many common findings and presentation that it makes more sense to be grouped together in a differential diagnosis. The common imaging finding is usually as a lung infiltrate or consolidation of some type of distribution or another. Trying to ... | 19 | xsh5bwcx | [
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bbe991ebb972aac748a88bf5b190ccdf | mteb/scifact | ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR). | Full activation of the T cell receptor requires both clustering and conformational changes at CD3.. T cell receptor (TCR-CD3) triggering involves both receptor clustering and conformational changes at the cytoplasmic tails of the CD3 subunits. The mechanism by which TCRalphabeta ligand binding confers conformational ch... | [
"CD28 Costimulation: From Mechanism to Therapy.. Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell receptor (TCR) ligation for naive T cell activation. Here, we discuss the expression, structure, and biochemistry of CD28 and its ligands. CD28 signals play a key role in many... | 550 | 33499189 | [
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] | scientific_claim_retrieval | scientific |
bc3e9d9b972dc0870dd0ade6361ed4a7 | mteb/scifact | Charcoal is an effective treatment for acute paraquat poisoning. | Effect of activated charcoal hemoperfusion on renal function in patients with paraquat poisoning.. The present study retrospectively analyzed 19 patients diagnosed with paraquat (PQ) poisoning with the aim to investigate the effect of activated charcoal hemoperfusion on renal function and PQ elimination. The results in... | [
"Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial. BACKGROUND The case-fatality for intentional self-poisoning in the rural developing world is 10-50-fold higher than that in industrialised countries, mostly because of the use of highly toxic pesticides and plants. We therefor... | 245 | 3430789 | [
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"19132741",
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"116792"
] | scientific_claim_retrieval | scientific |
49c1e06dbe323adca1d379a45ad4e73e | mteb/scifact | Normal granulomas form in the absence of TNF in Zebrafish. | Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death.. Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immune cel... | [
"Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study. Proteinase-activated receptors (PARs) belong to a family of G protein-coupled receptors. PARs are activated by a serin... | 860 | 16066726 | [
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42b2b7bb62f8aa62909a7746e8068ba6 | mteb/scifact | Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels. | Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli. Gram-negative bacteria have an outer membrane (OM) that functions as a barrier to protect the cell from toxic compounds such as antibiotics and detergents. The OM is a highly asymmetric bilayer composed of phospholipi... | [
"BMI-1 Autoantibody as a New Potential Biomarker for Cervical Carcinoma. BMI-1 is overexpressed in a variety of cancers, which can elicit an immune response leading to the induction of autoantibodies. However, BMI-1 autoantibody as a biomarker has seldom been studied with the exception of nasopharyngeal carcinoma. ... | 1033 | 6836086 | [
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] | scientific_claim_retrieval | scientific |
4d17f19c9f47cf0da0ddad31abb4a5b0 | mteb/scifact | The PDPN gene deactivates the C-type lectin receptor (CLEC-2). | Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2. To initiate adaptive immunity, dendritic cells (DCs) move from parenchymal tissues to lymphoid organs by migrating along stromal scaffolds that display the glycoprotein podoplanin (PDPN). PDPN is express... | [
"Persistence of HIV-1 Receptor-Positive Cells after HSV-2 Reactivation: A Potential Mechanism for Increased HIV-1 Acquisition. To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition, we conducted in situ analysis of the cellular infiltrate from sequential biopsies o... | 1173 | 7370282 | [
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] | scientific_claim_retrieval | scientific |
206805b7a9c0491e475061d847806132 | mteb/scifact | Upregulation of PD1 causes the downmodulation of Satb1. | SATB1 Expression Governs Epigenetic Repression of PD‐1 in Tumor‐Reactive T Cells. &NA; Despite the importance of programmed cell death‐1 (PD‐1) in inhibiting T cell effector activity, the mechanisms regulating its expression remain poorly defined. We found that the chromatin organizer special AT‐rich sequence‐binding p... | [
"Exercise causes a tissue-specific change of NO production in the kidney and lung.. Nitric oxide (NO) is produced in the vascular endothelium and is a potent vasodilator substance that participates in the regulation of local vascular tone. Exercise causes peculiar changes in systemic and regional blood flow, i.e., ... | 1349 | 5377642 | [
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] | scientific_claim_retrieval | scientific |
cdc4423b193382a31d694046c7945a2a | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | Professional and Home-Made Face Masks Reduce Exposure to Respiratory Infections among the General Population. BACKGROUND: Governments are preparing for a potential influenza pandemic. Therefore they need data to assess the possible impact of interventions. Face-masks worn by the general population could be an accessibl... | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | umvrwgaw | [
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fd4ffc60f7352b032693f7ec602dd0b3 | mteb/scifact | It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically. | Life is sweet: candy consumption and longevity.. Our attitude towards candy—“if it tastes that good, it can't be healthy”—betrays society's puritanical stance towards pleasure. Candy has been blamed for various ills, including hyperactivity in children; however, clinical trials have not supported this.1 Candy—sugar con... | [
"Statins in the primary prevention of cardiovascular disease. Statins are widely used in the evidence-based lowering of cardiovascular disease (CVD) risk. The use of these drugs for secondary prevention of CVD is well founded, but their expanding use in primary prevention—in individuals without documented CVD—has r... | 658 | 5293024 | [
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] | scientific_claim_retrieval | scientific |
011e6639a031b76429d0a1f647ceb96f | mteb/scifact | Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization. | Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation. DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that duplicate megabase-sized chromosome segments at specific times during S-phase. Cytogenetic studies show that these "replicon clusters" ... | [
"Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.. Induced pluripotent stem cells (iPSCs) can be derived from somatic cells by gene transfer of reprogramming transcription factors. Expression levels of these factors strongly influence the overall efficacy to f... | 243 | 8148122 | [
"24512417",
"3583084",
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] | scientific_claim_retrieval | scientific |
5ead528972bd36fec4633249d2c723aa | mteb/trec-covid | How much impact do masks have on preventing the spread of the COVID-19? | Professional and Home-Made Face Masks Reduce Exposure to Respiratory Infections among the General Population. BACKGROUND: Governments are preparing for a potential influenza pandemic. Therefore they need data to assess the possible impact of interventions. Face-masks worn by the general population could be an accessibl... | [
"Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques. The experimental infection of rhesus macaques (rh) with simian immunodeficiency virus (SIV) is an important model for human immunodeficiency virus (HIV) infection of humans. The interferon-induced transmembrane protein 3 (IFIT... | 44 | umvrwgaw | [
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] | biomedical_literature_retrieval | scientific |
ef3ce74240d7ca1cf274d6b6c7eacde7 | mteb/scifact | Tonic signaling from the scFv is amplified by MyD88/CD40. | 4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors. Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens. It remains un... | [
"NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.. Phosphatidylinositol-3-kinase (PI3K) pathway deregulation is a common event in human cancer, either through inactivation of the tumor suppressor phosphatase and tensin homologue ... | 1308 | 18231807 | [
"14241418",
"12658073",
"4474874",
"6363093"
] | scientific_claim_retrieval | scientific |
1f65290a9185f1c783c252eb4caf40cd | mteb/scifact | Forkhead 0 (fox0) transcription factors are involved in apoptosis. | Cell Stem Cell Review FoxO Transcription Factors and Stem Cell Homeostasis: Insights from the Hematopoietic System. The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism... | [
"Histone phosphorylation: a chromatin modification involved in diverse nuclear events.. Histone posttranslational modifications are key components of diverse processes that modulate chromatin structure. These marks function as signals during various chromatin-based events, and act as platforms for recruitment, asse... | 426 | 16728949 | [
"20630805",
"39580129",
"23535770",
"28697248"
] | scientific_claim_retrieval | scientific |
7bf86fff2e38ebcda590d9548bda9410 | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | The efficiency of surgical masks of varying design and composition. Five different types of surgical mask of varying design and composition of natural and synthetic fibres were tested for their efficiency in vivo by means of a special test chamber. Contaminated particles escaping through or around the mask during speec... | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | hq0owf31 | [
"5bwsb265",
"3okytwd8",
"jk7cn1p3",
"pyrfgggz"
] | biomedical_literature_retrieval | scientific |
b0443b9043207283a1429f59cd1136ef | mteb/scifact | Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine. | Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.. CONTEXT Hyperhomocysteinemia is caused by genetic and lifestyle influences, including low intakes of folate and vitamin B6. However, prospective data relating intake of these vitamins to risk of coronary heart di... | [
"Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial.. CONTEXT High plasma homocysteine levels are a risk factor for mortality and vascular disease in observational studies of patients with chronic kidney dis... | 645 | 12810152 | [
"33409100",
"21636085",
"37424881",
"36654066"
] | scientific_claim_retrieval | scientific |
855117a644fe8ba61f98a5e1fc488a97 | mteb/scifact | Tirasemtiv has no effect on cardiac muscle. | Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Limited neural input results in muscle weakness in neuromuscular disease because of a reduction in the density of muscle innervation, the rate of neuromuscular junction activation or the efficiency of sy... | [
"Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzyme.. Endothelin-1 (ET-1) is the predominant endothelin isopeptide generated by the vascular wall and therefore appears to be the most important peptide involved in regulation of cardiova... | 1302 | 12631697 | [
"6397191",
"6993046",
"4505748",
"2424794"
] | scientific_claim_retrieval | scientific |
535be317ad17e7d5cf85eb42a14bd721 | mteb/scifact | Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion. | Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial.. IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline and bupropion sustained-release (SR; com... | [
"Topiramate for smoking cessation: a randomized, placebo-controlled pilot study.. INTRODUCTION Topiramate (TOP) blocks glutamate receptors and facilitates GABA (γ-aminobutyric acid) neurotransmission, effects that may facilitate smoking cessation. We compared the effects of behavioral counseling combined with (a) T... | 1360 | 11614737 | [
"8570690",
"5114940",
"12409683",
"5551138"
] | scientific_claim_retrieval | scientific |
3c1909f0ad83d71bb76129ec432514cc | mteb/scifact | In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells. | Radiation and Dual Checkpoint Blockade Activates Non-Redundant Immune Mechanisms in Cancer. Immune checkpoint inhibitors result in impressive clinical responses, but optimal results will require combination with each other and other therapies. This raises fundamental questions about mechanisms of non-redundancy and res... | [
"CD8 Cells of Patients with Diffuse Cutaneous Leishmaniasis Display Functional Exhaustion: The Latter Is Reversed, In Vitro, by TLR2 Agonists. Leishmania mexicana (Lm) causes localized (LCL) and diffuse (DCL) cutaneous leishmaniasis. DCL patients have a poor cellular immune response leading to chronicity. It has be... | 576 | 4468861 | [
"14657344",
"9767444",
"2462673",
"79696454"
] | scientific_claim_retrieval | scientific |
4092b44f5ee28fef86c598a9741a2b73 | mteb/scifact | Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells. | Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines. Live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) remain the most efficacious of all vaccines in nonhuman primate models of HIV and AIDS, yet the basis of their robust protection remains poorly understood. Here we show t... | [
"Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen.. Dendritic cells (DCs) are crucial for mounting allergic airway inflammation, but it is unclear which subset of DCs performs this task. By using CD64 and MAR-1 staining, w... | 694 | 1071991 | [
"40365566",
"8182950",
"20311968",
"23573229"
] | scientific_claim_retrieval | scientific |
c11b208276d06585c9f687884e92b58d | mteb/scifact | Suboptimal nutrition is a leading cause of premature death | The state of US health, 1990-2010: burden of diseases, injuries, and risk factors.. IMPORTANCE Understanding the major health problems in the United States and how they are changing over time is critical for informing national health policy. OBJECTIVES To measure the burden of diseases, injuries, and leading risk facto... | [
"Pharmacological interventions for smoking cessation: an overview and network meta-analysis.. BACKGROUND Smoking is the leading preventable cause of illness and premature death worldwide. Some medications have been proven to help people to quit, with three licensed for this purpose in Europe and the USA: nicotine r... | 1109 | 8582337 | [
"5114940",
"32328114",
"4313478",
"21387297"
] | scientific_claim_retrieval | scientific |
9f7e9d831eba7761df7d1d2af740b714 | mteb/scifact | Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden. | Accuracy of weighed dietary records in studies of diet and health.. OBJECTIVE To provide an independent evaluation of seven day weighed dietary records, which are currently accepted as the most accurate technique for assessing habitual dietary intake in studies investigating the links between diet and health. DESIGN Su... | [
"Reversing the tide — diagnosis and prevention of T2DM in populations of African descent. Abstract | Populations of African descent are at the forefront of the worldwide epidemic of type 2 diabetes mellitus (T2DM). The burden of T2DM is amplified by diagnosis after preventable complications of the disease have occu... | 1375 | 21993510 | [
"12662435",
"8069939",
"16322674",
"41074251"
] | scientific_claim_retrieval | scientific |
f59604bcc40052f99f7405cf222b0623 | mteb/scifact | Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates. | Analyzing mechanisms of alternative pre-mRNA splicing using in vitro splicing assays.. The development of in vitro assays to analyze pre-mRNA splicing resulted in the discovery of many fundamental features characterizing splicing signals and the machinery that completes this process. Because in vitro assays can be mani... | [
"A coactivator of pre-mRNA splicing.. The nuclear matrix antigen recognized by the monoclonal antibody (mAb) B1C8 is a novel serine (S) and arginine (R)-rich protein associated with splicing complexes and is named here SRm160 (SR-related matrix protein of 160 kD). SRm160 contains multiple SR repeats, but unlike pro... | 963 | 29828242 | [
"10423989",
"30543439",
"16167746",
"16929739"
] | scientific_claim_retrieval | scientific |
7de511c96e915f7f0ab9180a5f91ed7c | mteb/scifact | DMS3 protein enables Pol V transcription in vivo. | Noncoding Transcription by RNA Polymerase Pol IVb/Pol V Mediates Transcriptional Silencing of Overlapping and Adjacent Genes. Nuclear transcription is not restricted to genes but occurs throughout the intergenic and noncoding space of eukaryotic genomes. The functional significance of this widespread noncoding transcri... | [
"The Glucocorticoid Receptor Inhibits. Glucocorticoids repress NFkappaB-mediated activation of proinflammatory genes such as interleukin-8 (IL-8) and ICAM-1. Our experiments suggest that the glucocorticoid receptor (GR) confers this effect by associating through protein-protein interactions with NFkappaB bound at e... | 304 | 14797520 | [
"14380875",
"6446747",
"26899920",
"7155555"
] | scientific_claim_retrieval | scientific |
4f44bfeb0a90c5cc1b8deafbbe4c2c52 | mteb/scifact | Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans. | Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.. OBJECTIVE To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN Case-control comparison of prevalence of IgG antibodies to H pylori in blood... | [
"Helicobacter pylori AlpA and AlpB bind host laminin and influence gastric inflammation in gerbils.. Helicobacter pylori persistently colonizes humans, causing gastritis, ulcers, and gastric cancer. Adherence to the gastric epithelium has been shown to enhance inflammation, yet only a few H. pylori adhesins have be... | 447 | 2052720 | [
"26488879",
"24705390",
"39550665",
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] | scientific_claim_retrieval | scientific |
5a618d0dca3dc84b58ed3899d045f372 | mteb/scifact | Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells. | Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors.. Recent studies have demonstrated direct reprogramming of fibroblasts into a range of somatic cell types, but to date stem or progenitor cells have only been reprogrammed for the blood and neuronal lineages. We previously reported generat... | [
"Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells.. Beta-cell replacement is considered to be the most promising approach for treatment of type 1 diabetes. Its application on a large scale is hindered by a shortage of cells for tran... | 624 | 20033112 | [
"37699461",
"5085118",
"14192687",
"3360421"
] | scientific_claim_retrieval | scientific |
93b90c47b3f6fdd1e673b1c29878eec9 | mteb/trec-covid | What are the observed mutations in the SARS-CoV-2 genome and how often do the mutations occur? | Host shifts result in parallel genetic changes when viruses evolve in closely related species. Host shifts, where a pathogen invades and establishes in a new host species, are a major source of emerging infectious diseases. They frequently occur between related host species and often rely on the pathogen evolving adapt... | [
"An evaluation of Comparative Genome Sequencing (CGS) by comparing two previously-sequenced bacterial genomes. BACKGROUND: With the development of new technology, it has recently become practical to resequence the genome of a bacterium after experimental manipulation. It is critical though to know the accuracy of t... | 40 | zlq4hucn | [
"sabz03c0",
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"pr8za61l"
] | biomedical_literature_retrieval | scientific |
affdffb3f2eb3eaec10a127f57af7a7f | mteb/scifact | MafA phosphorylation enhances its ubiquitination. | GSK-3-mediated phosphorylation enhances Maf-transforming activity.. The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 50% of human multiple myelomas. Here, we show that Maf-trans... | [
"Tissue Transglutaminase Is an Integrin-Binding Adhesion Coreceptor for Fibronectin. The protein cross-linking enzyme tissue transglutaminase binds in vitro with high affinity to fibronectin via its 42-kD gelatin-binding domain. Here we report that cell surface transglutaminase mediates adhesion and spreading of ce... | 746 | 11291348 | [
"10669582",
"18810195",
"33068577",
"7878807"
] | scientific_claim_retrieval | scientific |
1a00b262a5b07da770b3ce524ab5c9af | mteb/trec-covid | what are the initial symptoms of Covid-19? | Sudden onset anosmia and dysgeusia in two patients: An early sign of SARS-CoV-2 infection | [
"Impact of Asymptomatic Bacteriuria (ASBU) Overtreatment During a Controlled Trial of Antimicrobial Stewardship (AS). BACKGROUND: What are the clinical profiles, outcomes, and antimicrobial costs attributed to patients admitted with presumed urinary tract infection (UTI) but deemed to have “no infection” (NI) by in... | 26 | f1h2j6jx | [
"s5mcgocf",
"beqvgdjo",
"gwnjl686",
"cz85adrw"
] | biomedical_literature_retrieval | scientific |
48480ea56f2d1fa46353ad87c108793f | mteb/scifact | 4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers. | Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an importan... | [
"Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells.. Orai1 and stromal interaction molecule 1 (STIM1) mediate store-operated Ca(2+) entry (SOCE) in immune cells. STIM1, an endoplasmic reticulum (ER) Ca(2+) sensor, detects store depletion and inter... | 11 | 32587939 | [
"19561411",
"16546131",
"44562221",
"4680262"
] | scientific_claim_retrieval | scientific |
4d8bc474e620251d1b26fe72ff48fd12 | mteb/scifact | Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells. | KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for c... | [
"Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial.. CONTEXT Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic cardiomyopathy (ICM). Both autolog... | 689 | 22080671 | [
"40164383",
"23036207",
"18953920",
"8995263"
] | scientific_claim_retrieval | scientific |
e11f9146bd1456df9f5c5903db21cf29 | mteb/scifact | Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States. | Physician Emigration from Sub-Saharan Africa to the United States: Analysis of the 2011 AMA Physician Masterfile. BACKGROUND The large-scale emigration of physicians from sub-Saharan Africa (SSA) to high-income nations is a serious development concern. Our objective was to determine current emigration trends of SSA phy... | [
"Malaria eradication back on the table.. After a lapse of almost 40 years, malaria eradication is back on the global health agenda. Inspired by the Gates Malaria Forum in October 2007,1,2 key organizations are starting to debate the pros and cons of redefining eradication as an explicit goal of malaria control effo... | 96 | 14500725 | [
"37248570",
"30741007",
"12009265",
"34818263"
] | scientific_claim_retrieval | scientific |
fa5f0fa73dd4a82143a3f84e30802d03 | mteb/scifact | CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis. | CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis.. Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) express CD44v6, which is required f... | [
"PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2. Leukemias and other cancers possess self-renewing stem cells that help to maintain the cancer. Cancer stem cell eradication is thought to be crucial for successful anticancer therapy. Using an acute myeloid leukemi... | 203 | 9558539 | [
"8764879",
"14768471",
"11935250",
"7808055"
] | scientific_claim_retrieval | scientific |
cf702f6e08e826206aa7c7307f7d4fb5 | mteb/trec-covid | how long can the coronavirus live outside the body | Resistance of Enteric Viruses on Fomites. Human enteric viruses are associated with several clinical features, especially gastroenteritis. Large amounts of these viruses can be released in the environment and spread to people. Enteric viruses are nonenveloped viruses and have displayed good survival in the environment.... | [
"The impact of respiratory viruses on lung health after preterm birth. Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased... | 15 | tqqt0hj7 | [
"am4mdxok",
"dxdr6oan",
"49it5pha",
"mw7athol"
] | biomedical_literature_retrieval | scientific |
0b36f153edb82e0a811376a95d610cc1 | mteb/trec-covid | how long can the coronavirus live outside the body | Recommendations for the prevention of transmission of SARS during GI endoscopy | [
"The impact of respiratory viruses on lung health after preterm birth. Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased... | 15 | alo15byi | [
"am4mdxok",
"dxdr6oan",
"49it5pha",
"mw7athol"
] | biomedical_literature_retrieval | scientific |
c0439027d39495597fead360bf8aae99 | mteb/scifact | BCL-2 promotes the apoptotic effects of c-Myc. | Antiapoptotic BCL-2 is required for maintenance of a model leukemia.. Resistance to apoptosis, often achieved by the overexpression of antiapoptotic proteins, is common and perhaps required in the genesis of cancer. However, it remains uncertain whether apoptotic defects are essential for tumor maintenance. To test thi... | [
"The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells.. Isorhamnetin is one member of flavonoid components which has been used in the treatment of heart disease. Recently the in vitro anti-cancer effect of isorhamnetin on human esophageal squamous carcinoma cel... | 156 | 37549932 | [
"10218447",
"35962023",
"11900630",
"6121555"
] | scientific_claim_retrieval | scientific |
386c841300a6d1a52f60f6edc0681831 | mteb/scifact | Natriuretic peptides protect against diabetes. | Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies. BACKGROUND Genetic and epidemiological evidence suggests an inverse association between B-type natriuretic peptide (BNP) levels in blood and risk of type 2 diabetes (T2D), but the pro... | [
"Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes.. In type 1 diabetes (T1D), there is an intense inflammatory response that destroys the β cells in the pancreatic islets of Langerhans, the site where insulin is produced and released. A t... | 841 | 15663829 | [
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"34054472",
"20132778"
] | scientific_claim_retrieval | scientific |
9f391eaec44d6974037624b4ae15475a | mteb/scifact | Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume. | Radioiodine treatment of multinodular non-toxic goitre.. OBJECTIVE To investigate the long term effect of radioactive iodine on thyroid function and size in patients with non-toxic multinodular goitre. DESIGN Consecutive patients with multinodular non-toxic goitre selected for radioactive iodine treatment and followed ... | [
"Magnetic resonance imaging for volume estimation of large multinodular goitres: a comparison with scintigraphy.. As a result of increasing interest in non-surgical treatment for the reduction of goitre size the use of magnetic resonance (MR) imaging for volume estimation of large multinodular goitres was evaluated... | 1011 | 9745001 | [
"26026009",
"37912677",
"6670101",
"4246523"
] | scientific_claim_retrieval | scientific |
72a6ad7f1d9d214929b755b11644d5b2 | mteb/trec-covid | What is the mechanism of cytokine storm syndrome on the COVID-19? | Virus-Induced Immunopathology. Several viruses cause damage to the tissue by immunopathological mechanisms. This chapter presents the principal examples of immunopathogenesis caused by the viruses, accompanied by speculations about its management. The most common mechanism of lesion development in virus induced immunop... | [
"Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion. Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of asymptomatic persistence in recovering survivors is possible, durin... | 39 | 23tjgbhw | [
"32zroj99",
"daycobqe",
"hx6lkuj0",
"ts89jxrz"
] | biomedical_literature_retrieval | scientific |
1086044bb48e1b55623bf7122565d0e6 | mteb/scifact | Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers. | Risk factors at medical school for subsequent professional misconduct: multicentre retrospective case-control study. OBJECTIVE To determine whether there are risk factors in a doctor's time at medical school that are associated with subsequent professional misconduct. DESIGN Matched case-control study. Setting Records ... | [
"Monitoring effectiveness and safety of Tafamidis in transthyretin amyloidosis in Italy: a longitudinal multicenter study in a non-endemic area. Tafamidis is a transthyretin (TTR) stabilizer able to prevent TTR tetramer dissociation. There have been a few encouraging studies on Tafamidis efficacy in early-onset inh... | 1106 | 6710713 | [
"21323758",
"38630735",
"12205576",
"29090823"
] | scientific_claim_retrieval | scientific |
7f35c844e0e0a4604626f111f77a13c4 | mteb/scifact | siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model. | A20 is overexpressed in glioma cells and may serve as a potential therapeutic target.. OBJECTIVE A20 is a TNF-inducible primary response gene, which has been found to have antiapoptotic function in several cancer cells. This study investigates A20 expression in human glioma tissues and four glioma cell lines, and its e... | [
"Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer. The myc oncogene is overexpressed in almost half of all breast and ovarian cancers, but attempts at therapeutic interventions against myc have proven to be challenging. Myc regulates multiple biological p... | 1403 | 38355793 | [
"19358586",
"28334217",
"27647593",
"3545805"
] | scientific_claim_retrieval | scientific |
f80ccf9455f015057e68bd07ffcc74c9 | mteb/scifact | Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians. | Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO). We demonstrate here that metaboli... | [
"Fitting multilevel models in complex survey data with design weights: Recommendations. BACKGROUND Multilevel models (MLM) offer complex survey data analysts a unique approach to understanding individual and contextual determinants of public health. However, little summarized guidance exists with regard to fitting ... | 884 | 14803797 | [
"15040589",
"33684572",
"39187170",
"11181416"
] | scientific_claim_retrieval | scientific |
4840974ef94530acb6adb891f1437841 | mteb/scifact | KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions. | KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for c... | [
"Classification, functions, and clinical relevance of extracellular vesicles.. Both eukaryotic and prokaryotic cells release small, phospholipid-enclosed vesicles into their environment. Why do cells release vesicles? Initial studies showed that eukaryotic vesicles are used to remove obsolete cellular molecules. Al... | 663 | 22080671 | [
"7764903",
"10354110",
"2638387",
"25148216"
] | scientific_claim_retrieval | scientific |
0b6870042aa12c435c81c5064539cc76 | mteb/scifact | VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus. | PAAR-repeat proteins sharpen and diversify the Type VI secretion system spike. The bacterial type VI secretion system (T6SS) is a large multicomponent, dynamic macromolecular machine that has an important role in the ecology of many Gram-negative bacteria. T6SS is responsible for translocation of a wide range of toxic ... | [
"A view to a kill: the bacterial type VI secretion system.. The bacterial type VI secretion system (T6SS) is an organelle that is structurally and mechanistically analogous to an intracellular membrane-attached contractile phage tail. Recent studies determined that a rapid conformational change in the structure of ... | 1366 | 4406819 | [
"27731651",
"4465762",
"34846352",
"37643601"
] | scientific_claim_retrieval | scientific |
8a629b4aae8b4382420033128f9b8c9d | mteb/scifact | Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring. | Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Exuberant fibroproliferation is a common complication after injury for reasons that are not well understood. One key component of wound repair that is often overlooked is mechanical force, which regulates cell-matrix interactions ... | [
"Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCKindependent mechanism. The transition of cell–matrix adhesions from the initial punctate focal complexes into the mature elongated form, known as focal contacts, requires GTPas... | 632 | 5172048 | [
"9507605",
"28195565",
"44640124",
"5321708"
] | scientific_claim_retrieval | scientific |
e1418808b24636ee49c0d200626b95a4 | mteb/scifact | Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion. | Ultrasound imaging for lumbar punctures and epidural catheterisations: systematic review and meta-analysis.. OBJECTIVE To determine whether ultrasound imaging can reduce the risk of failed lumbar punctures or epidural catheterisations, when compared with standard palpation methods, and whether ultrasound imaging can re... | [
"Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial. BACKGROUND Deep vein thrombosis (DVT) and pulmonary embolism are common after stroke. In small trials of patients undergoing surgery, gr... | 1341 | 15482274 | [
"11718220",
"7986878",
"11109043",
"13072112"
] | scientific_claim_retrieval | scientific |
8e2045f3e7f0c0c9dccb6fa5ea215daa | mteb/scifact | Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States. | Physician Emigration from Sub-Saharan Africa to the United States: Analysis of the 2011 AMA Physician Masterfile. BACKGROUND The large-scale emigration of physicians from sub-Saharan Africa (SSA) to high-income nations is a serious development concern. Our objective was to determine current emigration trends of SSA phy... | [
"The financial cost of doctors emigrating from sub-Saharan Africa: human capital analysis. OBJECTIVE To estimate the lost investment of domestically educated doctors migrating from sub-Saharan African countries to Australia, Canada, the United Kingdom, and the United States. DESIGN Human capital cost analysis using... | 848 | 14500725 | [
"3662510",
"20999249",
"34818263",
"30844602"
] | scientific_claim_retrieval | scientific |
eecb8def0c6fd3464324de4244debefe | mteb/trec-covid | how long can the coronavirus live outside the body | Issues Concerning Survival of Viruses on Surfaces. Viruses are the causative agents of an estimated 60% of human infections worldwide. The most common viral illnesses are produced by enteric and respiratory viruses. Transmission of these viruses from an infected person or animal to a new host can occur via several rout... | [
"The impact of respiratory viruses on lung health after preterm birth. Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased... | 15 | 0e1qn4yv | [
"am4mdxok",
"dxdr6oan",
"49it5pha",
"mw7athol"
] | biomedical_literature_retrieval | scientific |
6de587895c078b0fcd344f3616edd98f | mteb/trec-covid | are there serological tests that detect antibodies to coronavirus? | Antibody epitope repertoire analysis enables rapid antigen discovery and multiplex serology. The detection of pathogen-specific antibodies remains a cornerstone of clinical diagnostics. Yet, many test exhibit undesirable performance or are completely lacking. Given this, we developed serum epitope repertoire analysis (... | [
"Estimating human-to-human transmissibility of hepatitis A virus in an outbreak at an elementary school in China, 2011. Hepatitis A is caused by hepatitis A virus and occurs worldwide. Estimating the transmissibility, which is usually characterized by the basic reproductive number R(0), the mean number of secondary... | 7 | equnyib7 | [
"3nk2ipyi",
"yiqdsf9z",
"h32821u0",
"2hchnlwb"
] | biomedical_literature_retrieval | scientific |
4085ee761ca8227e24a74308cbd0e636 | mteb/scifact | Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons. | Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive stranded RNA viruses. Although susceptibility of neurons in the brain to microbial infection is a major determinant of clinical outcome, little is known about the molecular factors governing ... | [
"Beta interferon controls West Nile virus infection and pathogenesis in mice.. Studies with mice lacking the common plasma membrane receptor for type I interferon (IFN-αβR(-)(/)(-)) have revealed that IFN signaling restricts tropism, dissemination, and lethality after infection with West Nile virus (WNV) or several... | 652 | 9433958 | [
"10559501",
"30437264",
"28644298",
"7155555"
] | scientific_claim_retrieval | scientific |
47130d35d10aaf26298ee804b8bbc754 | mteb/scifact | The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes. | Myeloid-specific Krüppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis.. RATIONALE Hemizygous deficiency of the transcription factor Krüppel-like factor 2 (KLF2) has been shown previously to augment atherosclerosis in hypercholesterolemic mice. However, the cell ty... | [
"Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Missense mutations in the CIAS1 gene cause three autoinflammatory disorders: familial cold autoinflammatory syndrome, Muckle–Wells syndrome and neonatal-onset multiple-system inflammatory disease. Cryopyrin (also called Nalp3),... | 1214 | 14407673 | [
"4345315",
"13902570",
"2774906",
"21498497"
] | scientific_claim_retrieval | scientific |
bb26c602eaaa4cd363eb36b10879381a | mteb/scifact | Active caspase-11 participate in regulating phagosome-lysosome fusion. | Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization.. Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once bacterial molecules are sensed wit... | [
"TRP channels of intracellular membranes.. Ion channels are classically understood to regulate the flux of ions across the plasma membrane in response to a variety of environmental and intracellular cues. Ion channels serve a number of functions in intracellular membranes as well. These channels may be temporarily ... | 78 | 5099266 | [
"8246090",
"13958154",
"38793927",
"15414628"
] | scientific_claim_retrieval | scientific |
cedacf939db4039fcde78849449557c8 | mteb/trec-covid | What is the mechanism of cytokine storm syndrome on the COVID-19? | Nuclear factor k B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy | [
"Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion. Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of asymptomatic persistence in recovering survivors is possible, durin... | 39 | 5xw6ceoq | [
"32zroj99",
"daycobqe",
"hx6lkuj0",
"ts89jxrz"
] | biomedical_literature_retrieval | scientific |
123f5f624a6396c1978e3905c41b1f5a | mteb/scifact | Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum. | Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia. BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part of normal adult haemoglobin (Hb). Individuals homozygous for... | [
"Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparum.. Background. Artemisinin-based combination therapy (ACT) reduces microscopically confirmed gametocytemia and mosquito infection. However, molecular techniques have recently revealed high prevalences of submicroscopic... | 928 | 18174210 | [
"10617916",
"9254550",
"13514898",
"24632480"
] | scientific_claim_retrieval | scientific |
38c22f93ca650a720f65b320842fb740 | mteb/scifact | IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active. | High abundance of plasma cells secreting transglutaminase 2–specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions. Celiac disease is an immune-mediated disorder in which mucosal autoantibodies to the enzyme transglutaminase 2 (TG2) are generated in response to the exogenous... | [
"Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis.. BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG autoantibodies. It is not known whether this represents a local mucosal res... | 553 | 1471041 | [
"10675756",
"8995263",
"3828508",
"16252863"
] | scientific_claim_retrieval | scientific |
87f30fa06b11440139be79870048c646 | mteb/scifact | Monoclonal antibody targeting of N-cadherin inhibits castration resistance. | Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance. The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing gene expression in isogenic androgen-dependent and CRPC xe... | [
"Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape. Neutralizing antibodies are likely to play a crucial part in a preventative HIV-1 vaccine. Although efforts to elicit broadly cross-neutralizing (BCN) antibodies by vaccination have been unsuccessful, a minority of in... | 803 | 22180793 | [
"7177329",
"25543207",
"14241418",
"6083952"
] | scientific_claim_retrieval | scientific |
ae7ca95de6e530d9252a3e3b7dff5c48 | mteb/scifact | Charcoal shows no benefit for acute paraquat poisoning. | Systematic review of controlled clinical trials of gastric lavage in acute organophosphorus pesticide poisoning.. BACKGROUND Organophosphorus pesticide (OP) self-poisoning is a major problem in the developing rural world. There is little clinical trial data to guide therapy, hindering the identification of best therapy... | [
"Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial. BACKGROUND The case-fatality for intentional self-poisoning in the rural developing world is 10-50-fold higher than that in industrialised countries, mostly because of the use of highly toxic pesticides and plants. We therefor... | 246 | 8447873 | [
"12209494",
"24097933",
"19132741",
"33203108"
] | scientific_claim_retrieval | scientific |
a1f5221f423011c3b96ffc9cdd25f687 | mteb/scifact | Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos. | A chikungunya fever vaccine utilizing an insect-specific virus platform. Traditionally, vaccine development involves tradeoffs between immunogenicity and safety. Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety when compared to inactivated vaccines. In contrast, the inability ... | [
"Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape. Neutralizing antibodies are likely to play a crucial part in a preventative HIV-1 vaccine. Although efforts to elicit broadly cross-neutralizing (BCN) antibodies by vaccination have been unsuccessful, a minority of in... | 853 | 24922825 | [
"7177329",
"3566945",
"4373433",
"152245"
] | scientific_claim_retrieval | scientific |
0c02c099126664a28e476c9d86fdedb3 | mteb/scifact | Cellular clocks are associated with mitosis timing in NIH 3T3 cells. | Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells. Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead to synchronization. Here, we estimated the mutual interaction... | [
"BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges.. Mutations in BLM cause Bloom's syndrome, a disorder associated with cancer predisposition and chromosomal instability. We investigated whether BLM plays a role in ensuring the faithful chromosom... | 241 | 2212067 | [
"25550665",
"23918031",
"516867",
"52925737"
] | scientific_claim_retrieval | scientific |
ab1aeb91caee698a068850921d5c280f | mteb/scifact | Integrated care is ineffective at tackling multiple comorbidities. | Functional outcomes of multi-condition collaborative care and successful ageing: results of randomised trial. OBJECTIVE To evaluate the effectiveness of integrated care for chronic physical diseases and depression in reducing disability and improving quality of life. DESIGN A randomised controlled trial of multi-condit... | [
"Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus.. CONTEXT Although acute hypoglycemia may be associated with cognitive impairment in children with type 1 diabetes, no studies to date have evaluated whether hypoglycemia is a risk factor for dementia in older patients with ... | 647 | 15041758 | [
"13282296",
"6517267",
"19945096",
"6171953"
] | scientific_claim_retrieval | scientific |
da5881641f3dc07f967564c9706f5064 | mteb/scifact | DUSP4 downregulation deactivates the Ras-ERK pathway | Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance. Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, which c... | [
"Non-canonical PI3K-Cdc42-Pak-Mek-Erk Signaling Promotes Immune-Complex-Induced Apoptosis in Human Neutrophils. Neutrophils are peripheral blood leukocytes that represent the first line of immune cell defense against bacterial and fungal infections but are also crucial players in the generation of the inflammatory ... | 308 | 7821634 | [
"9225850",
"85665741",
"5321708",
"6121555"
] | scientific_claim_retrieval | scientific |
ecb0078c765ace87af85c9af96efbeb2 | mteb/trec-covid | are there serological tests that detect antibodies to coronavirus? | Novel protein chip for the detection of antibodies against infectious bronchitis virus. BACKGROUND: Infectious bronchitis (IB) caused by the IB virus (IBV) can cause acute damage to chickens around the world. Therefore, rapid diagnosis and immune status determination are critical for controlling IBV outbreaks. Enzyme-l... | [
"Estimating human-to-human transmissibility of hepatitis A virus in an outbreak at an elementary school in China, 2011. Hepatitis A is caused by hepatitis A virus and occurs worldwide. Estimating the transmissibility, which is usually characterized by the basic reproductive number R(0), the mean number of secondary... | 7 | lwirkob3 | [
"3nk2ipyi",
"yiqdsf9z",
"h32821u0",
"2hchnlwb"
] | biomedical_literature_retrieval | scientific |
c7c2481ac8395feefa5fa469cd315b06 | mteb/trec-covid | what evidence is there related to COVID-19 super spreaders | Using Modelling to Disentangle the Relative Contributions of Zoonotic and Anthroponotic Transmission: The Case of Lassa Fever. BACKGROUND: Zoonotic infections, which transmit from animals to humans, form the majority of new human pathogens. Following zoonotic transmission, the pathogen may already have, or may acquire,... | [
"Molecular Genetic Insights on Cheetah (Acinonyx jubatus) Ecology and Conservation in Namibia. The extent and geographic patterns of molecular genetic diversity of the largest remaining free-ranging cheetah population were described in a survey of 313 individuals from throughout Namibia. Levels of relatedness, incl... | 14 | q9lfnu6s | [
"xe0xey1n",
"1u44tdrj",
"rjyu8lfl",
"acidfmjc"
] | biomedical_literature_retrieval | scientific |
e0d80cc3afbe3c2b13f4fc763f0d2081 | mteb/scifact | The one-child policy has created a hospitable environment for female infants. | Perinatal mortality in rural China: retrospective cohort study.. OBJECTIVES To explore the use of local civil registration data to assess the perinatal mortality in a typical rural county in a less developed province in China, 1999-2000. DESIGN Retrospective cohort study. Pregnancies in a cohort of women followed from ... | [
"Strategies for optimizing maternal nutrition to promote infant development. BACKGROUND The growing appreciation of the multi-faceted importance of optimal maternal nutrition to the health and development of the infant and young child is tempered by incompletely resolved strategies for combatting challenges. OBJECT... | 1246 | 7662395 | [
"49429882",
"70455704",
"1946610",
"25653703"
] | scientific_claim_retrieval | scientific |
106313e3f324d0d63d948fb67d7a86ad | mteb/trec-covid | How has the COVID-19 pandemic impacted mental health? | Mental health: why it still matters in the midst of a pandemic | [
"What Effect Did the Global Financial Crisis Have Upon Youth Wellbeing? Evidence From Four Australian Cohorts. Recent research has suggested significant negative effects of the Global Financial Crisis (GFC) on mental health and wellbeing. In this article, the authors suggest that the developmental period of late ad... | 45 | x6madqnl | [
"35c6mak0",
"nbjili3v",
"hmh4s3w4",
"cf39dhpo"
] | biomedical_literature_retrieval | scientific |
6c66f1c7abc8f6713766c19c393fc421 | mteb/trec-covid | How much impact do masks have on preventing the spread of the COVID-19? | The role of masks and respirator protection against SARS-CoV-2 | [
"Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques. The experimental infection of rhesus macaques (rh) with simian immunodeficiency virus (SIV) is an important model for human immunodeficiency virus (HIV) infection of humans. The interferon-induced transmembrane protein 3 (IFIT... | 44 | 8w0cquhn | [
"beqvgdjo",
"y09mca1m",
"0quwwawp",
"rdnrbwkq"
] | biomedical_literature_retrieval | scientific |
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