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864d0a303d08adc8dc93786dbb05373b | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | Nuclear factor k B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | 5xw6ceoq | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
d911bec70434ded19e4fb79317d408dd | mteb/scifact | In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common. | Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts. Whereas domestication of livestock, pets, and crops is well documented, it is still unclear to what extent microbes associated with the production of food have also undergone human selection and where the plethora of industrial strains originates fro... | [
"Antagonistic Controls of Autophagy and Glycogen Accumulation by Snf1p, the Yeast Homolog of AMP-Activated Protein Kinase, and the Cyclin-Dependent. In the yeast Saccharomyces cerevisiae, glycogen is accumulated as a carbohydrate reserve when cells are deprived of nutrients. Yeast mutated in SNF1, a gene encoding a... | 573 | 10300888 | [
"7548577",
"25787749",
"13613916",
"365896"
] | scientific_claim_retrieval | scientific |
0353043a0075e752ac23fc86be99260a | mteb/scifact | 76-85% of people with severe mental disorder receive no treatment in low and middle income countries. | Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys.. CONTEXT Little is known about the extent or severity of untreated mental disorders, especially in less-developed countries. OBJECTIVE To estimate prevalence, severity, and treatment of D... | [
"Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study. BACKGROUND Results of the few cohort studies from countries with low incomes or middle incomes suggest a lower incidence of dementia tha... | 22 | 6490571 | [
"14682243",
"21274919",
"35022568",
"25293616"
] | scientific_claim_retrieval | scientific |
87b4700c00e3fab4407b63b08cc15fb6 | mteb/scifact | Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis. | Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study.. OBJECTIVE To examine whether past high sun exposure is associated with a reduced risk of multiple sclerosis. DESIGN Population based case-control study. SETTING Tasmania, latitudes 41-3 degrees S. PARTICIPANTS 136 cases with mult... | [
"British Journal of Nutrition (2003), 89, 295–301 q The Authors 2003 DOI: 10.1079/BJN2002776 Plasma homocysteine concentration is decreased by dietary intervention*. High plasma total homocysteine (tHcy) concentration is reported to be a risk factor for vascular diseases. We investigated the extent to which serum f... | 622 | 17000834 | [
"18557974",
"4442799",
"4515975",
"3034412"
] | scientific_claim_retrieval | scientific |
407e6f3dc7ab33cdb4b8c8cd09332ab0 | mteb/scifact | A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years. | Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene. Background Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increased rate of macrosomia in the offspring of pregnant women with... | [
"Prepregnancy BMI and the risk of gestational diabetes: a systematic review of the literature with meta-analysis.. The objective of this study is to assess and quantify the risk for gestational diabetes mellitus (GDM) according to prepregnancy maternal body mass index (BMI). The design is a systematic review of obs... | 44 | 56893404 | [
"439670",
"31889025",
"2138767",
"8524891"
] | scientific_claim_retrieval | scientific |
bbddbdf4c8ba6829ce3f3f44ffee033b | mteb/trec-covid | How much impact do masks have on preventing the spread of the COVID-19? | Infection prevention and control in paediatric office settings. Transmission of infection in the paediatric office is an issue of increasing concern. This document discusses routes of transmission of infection and the principles of current infection control measures. Prevention includes appropriate office design and ad... | [
"Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques. The experimental infection of rhesus macaques (rh) with simian immunodeficiency virus (SIV) is an important model for human immunodeficiency virus (HIV) infection of humans. The interferon-induced transmembrane protein 3 (IFIT... | 44 | fojzhlzx | [
"beqvgdjo",
"y09mca1m",
"0quwwawp",
"rdnrbwkq"
] | biomedical_literature_retrieval | scientific |
ba309b04b70bc5207bbfdc140f2f6c92 | mteb/scifact | Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2. | Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial.. BACKGROUND Human papillomavirus (HPV) testing is more sensitive for the detection of high-grade cervical lesions than is cytology, but detection of HPV ... | [
"Efficacy of HPV DNA testing with cytology triage and/or repeat HPV DNA testing in primary cervical cancer screening.. BACKGROUND Primary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cervical cells with a Pap test (cytology) has been evaluated in randomized clin... | 972 | 9764256 | [
"6561200",
"16980892",
"76415938",
"46355579"
] | scientific_claim_retrieval | scientific |
c6378321b066398ddbfd40a3997dc406 | mteb/scifact | Klf4 is important for proper myeloid cell differentiation. | The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.. Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify t... | [
"Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling.. Chronic inflammation constitutes an important link between obesity and its pathophysiological sequelae. In contrast to the belief that inflammatory signals exert a fundamentally negative impact on metabolism, we show that pro... | 668 | 6493422 | [
"5106691",
"15983148",
"21932050",
"23460562"
] | scientific_claim_retrieval | scientific |
29bc8d0b9487a0da33a4ba7c59b38e16 | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | Personal respirators for population level control of the COVID19 pandemic | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | k8ko5sfk | [
"gqa526yl",
"4y5ofjgt",
"aqv7xhng",
"yo4arwoi"
] | biomedical_literature_retrieval | scientific |
e7a0b70d7d3ea94d7fb133f3d917ba59 | mteb/scifact | Tirasemtiv targets fast-twitch muscle. | Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Limited neural input results in muscle weakness in neuromuscular disease because of a reduction in the density of muscle innervation, the rate of neuromuscular junction activation or the efficiency of sy... | [
"Altered microRNA expression in bovine skeletal muscle with age.. Age-dependent decline in skeletal muscle function leads to several inherited and acquired muscular disorders in elderly individuals. The levels of microRNAs (miRNAs) could be altered during muscle maintenance and repair. We therefore performed a comp... | 1305 | 12631697 | [
"37438296",
"8002887",
"31001322",
"21366394"
] | scientific_claim_retrieval | scientific |
f298b62b1133b8b45979324ad0c76b30 | mteb/scifact | MICAL redox enzymes regulate actin dynamics in many cell types. | Differential regulation of actin microfilaments by human MICAL proteins.. The Drosophila melanogaster MICAL protein is essential for the neuronal growth cone machinery that functions through plexin- and semaphorin-mediated axonal signaling. Drosophila MICAL is also involved in regulating myofilament organization and sy... | [
"Mical links semaphorins to F-actin disassembly. How instructive cues present on the cell surface have their precise effects on the actin cytoskeleton is poorly understood. Semaphorins are one of the largest families of these instructive cues and are widely studied for their effects on cell movement, navigation, an... | 737 | 6609935 | [
"4417558",
"3506723",
"6784372",
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] | scientific_claim_retrieval | scientific |
5f3a6593f6f65dfc6919cc37bbd9d1ef | mteb/scifact | Deletion of ATM and Rad3 related protein leads to acute tissue loss. | Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.. Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the ATR checkpoint regulator cause developmental defects in mice ... | [
"Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice. Age-related changes in the niche have long been postulated to impair the function of somatic stem cells. Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantially reduce... | 326 | 40349336 | [
"19912367",
"7093809",
"29691654",
"4323449"
] | scientific_claim_retrieval | scientific |
069f02c9cb432ff139ba319aae9d9343 | mteb/scifact | H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells. | Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Infection with Helicobacter pylori (H. pylori) is a risk factor for the development of gastric cancer. Here we show that infection of gastric epithelial cells with 'cag' pathogenicity island (cagPA... | [
"Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia.. BACKGROUND & AIMS Chronic infection with the bacterial pathogen Helicobacter pylori causes gastric disorders, ranging from chronic gastritis to gastric adenocarcinoma. Only a subset of infected persons will develop over... | 483 | 22703082 | [
"39550665",
"20330519",
"7465900",
"4422723"
] | scientific_claim_retrieval | scientific |
e0126f0f0065c9b81cf17ee6b5185f23 | mteb/scifact | Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence. | Anxiety. OBJECTIVES To examine the effect of routinely administered psychiatric questionnaires on the recognition, management, and outcome of psychiatric disorders in non-psychiatric settings. DATA SOURCES Embase, Medline, PsycLIT, Cinahl, Cochrane Controlled Trials Register, and hand searches of key journals. METHODS ... | [
"Clinical use of bone densitometry: scientific review.. CONTEXT Osteoporosis causes substantial morbidity and costs $13.8 billion annually in the United States. Measurement of bone mass by densitometry is a primary part of diagnosing osteoporosis and deciding a preventive treatment course. Bone mineral densitometry... | 762 | 4695046 | [
"16812091",
"19408393",
"44387884",
"21479231"
] | scientific_claim_retrieval | scientific |
2c04fbcb683025095667bbe9d10f4437 | mteb/scifact | Energy balance requires hypothalamic glutamate neurotransmission. | Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes.. Glial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy balance. Leptin, a key regulator of appetite and metabolism, has previously bee... | [
"The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.. BACKGROUND Relapse to cocaine seeking has been linked with low glutamate in the nucleus accumbens core (NAcore) causing potentiation of synaptic glutamate transmission from prefrontal cortex (PFC) afferents. Syste... | 378 | 17150648 | [
"4700428",
"16398827",
"2481032",
"14782049"
] | scientific_claim_retrieval | scientific |
74e749dfaa148f5b0b602d312de8095e | mteb/trec-covid | what is known about an mRNA vaccine for the SARS-CoV-2 virus? | Characterization of RNA in Saliva. Background: We have previously shown that human mRNAs are present in saliva and can be used as biomarkers of oral cancer. In this study, we analyzed the integrity, sources, and stability of salivary RNA. Methods: We measured the integrity of salivary RNA with reverse transcription fol... | [
"Gold nanoparticles for preparation of antibodies and vaccines against infectious diseases. Introduction: Vaccination remains very effective in stimulating protective immune responses against infections. An important task in antibody and vaccine preparation is to choose an optimal carrier that will ensure a high im... | 50 | zn10rnrm | [
"1tn3a4qs",
"299oohbp",
"msmq91d2",
"184kmuiy"
] | biomedical_literature_retrieval | scientific |
51aea3bab6699843ae9f43b90303282a | mteb/scifact | RAD52 is involved in break-induced DNA replication (BIR). | Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes.. Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere maintenance mechanism that occurs in a subset of cancers. By analyzing telomerase-positive cells and their human TERC knock... | [
"Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival. Neutrophil apoptosis is a highly regulated process essential for inflammation resolution, the molecular mechanisms of which are only partially elucidated. In this study, we describe a survival pathway controlle... | 1003 | 4319844 | [
"15248287",
"6144969",
"34198365",
"7468449"
] | scientific_claim_retrieval | scientific |
8fd011cc5a7d2770b35c3f61b2cfc189 | mteb/scifact | Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs. | Microenvironmental regulation of tumor progression and metastasis. Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable and thus represent an attractive th... | [
"miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts.. AIMS Tumor microenvironment is a strong determinant for the acquisition of metastatic potential of cancer cells. We have recently demonstrated that cancer-associated fibroblasts (CAFs) elicit a redox-dependent epithe... | 225 | 6944800 | [
"8702697",
"32742683",
"24974080",
"3727986"
] | scientific_claim_retrieval | scientific |
93ff4eb6205ec96d00875e158433ec37 | mteb/scifact | Aggravated inflammation is dependent on NLRP3 inflammasome activation. | Gout-associated uric acid crystals activate the NALP3 inflammasome. Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tissues.... | [
"Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors. The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs), which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ)–producing T lympho... | 93 | 2692522 | [
"5386514",
"3761017",
"40312663",
"11837657"
] | scientific_claim_retrieval | scientific |
6f807e0a73db69396448a7eb40f3ba87 | mteb/scifact | 5'-nucleotidase metabolizes 6MP. | Relapse specific mutations in NT5C2 in childhood acute lymphoblastic leukemia. Relapsed childhood acute lymphoblastic leukemia (ALL) carries a poor prognosis, despite intensive retreatment, owing to intrinsic drug resistance. The biological pathways that mediate resistance are unknown. Here, we report the transcriptome... | [
"Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL. Acute lymphoblastic leukemia (ALL) is an aggressive hematological tumor resulting from the malignant transformation of lymphoid progenitors. Despite intensive chemotherapy, 20% of pediatric patients and over 50% of a... | 14 | 641786 | [
"6421792",
"393001",
"8327914",
"409280"
] | scientific_claim_retrieval | scientific |
d194b7a2b46dd7b476493b0421787428 | mteb/scifact | Inside the body, falciparum parasites reproduce asexually. | Malaria biology and disease pathogenesis: insights for new treatments. Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan, claims the lives of nearly a million children each year in Africa alone and is a top public health concern. Evidence is accumulating that resistance to artemisinin... | [
"Spatial and temporal heterogeneity of Anopheles mosquitoes and Plasmodium falciparum transmission along the Kenyan coast.. The seasonal dynamics and spatial distributions of Anopheles mosquitoes and Plasmodium falciparum parasites were studied for one year at 30 villages in Malindi, Kilifi, and Kwale Districts alo... | 640 | 6503185 | [
"8373753",
"3770726",
"12409683",
"29381091"
] | scientific_claim_retrieval | scientific |
7c40241c25ca33feba4c77c3315db382 | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | Uncertainty, risk analysis and change for Ebola personal protective equipment guidelines | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | vvsy8qsz | [
"5bwsb265",
"3okytwd8",
"jk7cn1p3",
"pyrfgggz"
] | biomedical_literature_retrieval | scientific |
03cc6d4421fabb3572421b3c4da5f0d9 | mteb/scifact | Walking in traffic areas in London improves lung function in elderly adults. | Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study. BACKGROUND Long-term exposure to pollution can lead to... | [
"High prevalence of asthma in cross country skiers.. OBJECTIVES To study the prevalence of asthma (asthma symptoms and bronchial hyperresponsiveness) in Swedish cross country skiers compared with non-skiers and monitor changes in symptoms and bronchial hyperresponsiveness during the year. DESIGN Cross sectional stu... | 1373 | 21003930 | [
"2891825",
"118568",
"40631095",
"711256"
] | scientific_claim_retrieval | scientific |
5be0b919e20fe592ea56fdb75359e036 | mteb/scifact | The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks. | Using Routine Surveillance Data to Estimate the Epidemic Potential of Emerging Zoonoses: Application to the Emergence of US Swine Origin Influenza A H3N2v Virus. BACKGROUND Prior to emergence in human populations, zoonoses such as SARS cause occasional infections in human populations exposed to reservoir species. The r... | [
"Adapting the WHO package of essential noncommunicable disease interventions, Samoa. Problem Samoa has been struggling to address the burden of noncommunicable diseases at the health system, community and individual levels. Approach The World Health Organization (WHO) package of essential noncommunicable disease in... | 1186 | 7485455 | [
"51972698",
"15670968",
"45218443",
"5710820"
] | scientific_claim_retrieval | scientific |
a1951d859c0e9e4605ede79a225500da | mteb/scifact | Rising temperatures caused by global warming increases risk of dengue fever transmission. | Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages. BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors related to the human host, virus, mosquito vector, and envi... | [
"Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis. BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas. We ... | 1052 | 18816720 | [
"2097256",
"27866735",
"8063697",
"581832"
] | scientific_claim_retrieval | scientific |
ec9bd76178d86302371e8e4ed297a57a | mteb/scifact | Myelin sheaths are lipid-rich cellular structures. | Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy. We report a newly developed technique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and peripheral nerve that requires no fluorescent labeling. This method, based on sp... | [
"GRSF1 Regulates RNA Processing in Mitochondrial RNA Granules. Various specialized domains have been described in the cytosol and the nucleus; however, little is known about compartmentalization within the mitochondrial matrix. GRSF1 (G-rich sequence factor 1) is an RNA binding protein that was previously reported ... | 817 | 17814815 | [
"13931771",
"14328288",
"37727521",
"39174007"
] | scientific_claim_retrieval | scientific |
f9981d0c6bd7b39d34e821cb66bd00b7 | mteb/trec-covid | how has COVID-19 affected Canada | Canada and COVID-19: learning from SARS | [
"Effects of memory on the shapes of simple outbreak trees. Genomic tools, including phylogenetic trees derived from sequence data, are increasingly used to understand outbreaks of infectious diseases. One challenge is to link phylogenetic trees to patterns of transmission. Particularly in bacteria that cause chroni... | 9 | c7cd91pg | [
"mcdfcc8v",
"78395e3t",
"iwu022jh",
"44mvuunh"
] | biomedical_literature_retrieval | scientific |
56b840455a8458ca603d593c4ab88f58 | mteb/scifact | Headaches are correlated with cognitive impairment. | Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing-MRI study. OBJECTIVE To evaluate the association of overall and specific headaches with volume of white matter hyperintensities, brain infarcts, and cognition. DESIGN Population based, cross sectional study. ... | [
"Hyperactive Neuroendocrine Secretion Causes Size, Feeding, and Metabolic Defects of C. elegans Bardet-Biedl Syndrome Mutants. Bardet-Biedl syndrome, BBS, is a rare autosomal recessive disorder with clinical presentations including polydactyly, retinopathy, hyperphagia, obesity, short stature, cognitive impairment,... | 500 | 17930286 | [
"1281769",
"58564850",
"19804204",
"7239105"
] | scientific_claim_retrieval | scientific |
ad82ad08a516d041f437f9a2ba55b81d | mteb/scifact | EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells. | Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors. The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs), which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ)–producing T lymphocytes... | [
"Alkylating agent melphalan augments the efficacy of adoptive immunotherapy using tumor-specific CD4+ T cells.. In recent years, the immune-potentiating effects of some widely used chemotherapeutic agents have been increasingly appreciated. This provides a rationale for combining conventional chemotherapy with immu... | 363 | 5386514 | [
"20610557",
"13231899",
"7343711",
"18237384"
] | scientific_claim_retrieval | scientific |
f6ca96a7b67e46d48b6f44b1f2f21571 | mteb/scifact | The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death. | NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions. Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflammatory bowel diseases (IBD). IEC-... | [
"TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis.. The MAP kinase kinase kinase TGFβ-activated kinase 1 (TAK1) is activated by TLRs, IL-1, TNF, and TGFβ and in turn activates IKK-NF-κB and JNK, which regulate cell survival, growth, tumorigenesis, and metabolism. TAK1 signa... | 1170 | 18956141 | [
"3504761",
"17648235",
"21199527",
"8764879"
] | scientific_claim_retrieval | scientific |
15d89dfc52bab4cd36132762fe72611c | mteb/scifact | Low expression of miR7a does not repress target genes or exert a biological function in ovaries. | Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance.. Recent studies have reported that competitive endogenous RNAs (ceRNAs) can act as sponges for a microRNA (miRNA) through their binding sites and that changes in ceRNA abundances from individual genes can modulate the activity ... | [
"Activated AMPK boosts the Nrf2/HO-1 signaling axis—A role for the unfolded protein response. In light of the emerging interplay between redox and metabolic signaling pathways we investigated the potential cross talk between nuclear factor E2-related factor 2 (Nrf2) and AMP-activated kinase (AMPK), central regulato... | 713 | 18421962 | [
"9752604",
"15635366",
"23938319",
"30908508"
] | scientific_claim_retrieval | scientific |
285e1c8f3dc6a325ec6c928a1aa23b7b | mteb/scifact | Urbanization is an important risk factor related to the transmission of dengue fever. | Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages. BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors related to the human host, virus, mosquito vector, and envi... | [
"Breast cancer and obesity: an update.. Obesity has a complicated relationship to both breast cancer risk and the clinical behavior of the established disease. In postmenopausal women, particularly the elderly, various measures of obesity have been positively associated with risk. However, before menopause increase... | 1353 | 18816720 | [
"25973484",
"5035827",
"36651210",
"23377475"
] | scientific_claim_retrieval | scientific |
d9f5cef0f8fe673660c171069e74cd26 | mteb/scifact | The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin. | Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. The functional heart is comprised of distinct mesoderm-derived lineages including cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse embryo and the mouse embryonic stem cell differenti... | [
"Smooth muscle lineage diversity in the chick embryo. Two types of aortic smooth muscle cell differ in growth and receptor-mediated transcriptional responses to transforming growth factor-beta.. Lineage analysis studies in the avian embryo have identified two types of smooth muscle cells (SMCs) in the tunica media ... | 1239 | 4427392 | [
"32797183",
"6148876",
"4020950",
"51865482"
] | scientific_claim_retrieval | scientific |
de8210e2a8f69b05e1906228a8808fc9 | mteb/trec-covid | what evidence is there for dexamethasone as a treatment for COVID-19? | Successful steroid treatment for acute fibrinous and organizing pneumonia: A case report. BACKGROUND: Since the acute fibrinous and organizing pneumonia (AFOP) was first described by Beasley in 2002, some case reports of patients aged from 38 d to 80 years have been published worldwide, but there is still no standard t... | [
"Soluble immune checkpoints in cancer: production, function and biological significance. Immune checkpoints play important roles in immune regulation, and blocking immune checkpoints on the cell membrane is a promising strategy in the treatment of cancer. Based on this, monoclonal antibodies are having much rapid d... | 46 | tx4acpgq | [
"d3d1n9qa",
"36gbl7tu",
"72s8wpla",
"cpjlzutk"
] | biomedical_literature_retrieval | scientific |
46238f94e87178f5f2c9ca46226febd8 | mteb/trec-covid | what evidence is there related to COVID-19 super spreaders | Criminalizing Health-Related Behaviors Dangerous to Others? Disease Transmission, Transmission-Facilitation, and the Importance of Trust. Statutes criminalizing behavior that risks transmission of HIV/AIDS exemplify use of the criminal law against individuals who are victims of infectious disease. These statutes, despi... | [
"Molecular Genetic Insights on Cheetah (Acinonyx jubatus) Ecology and Conservation in Namibia. The extent and geographic patterns of molecular genetic diversity of the largest remaining free-ranging cheetah population were described in a survey of 313 individuals from throughout Namibia. Levels of relatedness, incl... | 14 | r9bud8ah | [
"xe0xey1n",
"1u44tdrj",
"rjyu8lfl",
"acidfmjc"
] | biomedical_literature_retrieval | scientific |
46c4a80e431a8c86370e0aae4fc51012 | mteb/scifact | NAC destabilizes NO to increase the effect of contrast agents on renal functions. | Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial.. CONTEXT The antioxidant acetylcysteine prevents acute contrast nephrotoxicity in patients with impaired renal function who undergo computed tomography scanning... | [
"Differential Effects of N-Acetylcysteine, Theophylline or Bicarbonate on Contrast-Induced Rat Renal Vasoconstriction. Background: Vasoconstriction and reactive oxygen species (ROS) accumulation following contrast media (CM) injection are the key factors triggering CM-induced nephropathy. We compared the effects of... | 826 | 4678846 | [
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] | scientific_claim_retrieval | scientific |
41a002c79a1b1e6b16a3fd26ab56fbb7 | mteb/scifact | Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals. | Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. The only proven requirement for ascorbic acid (vitamin C) is in preventing scurvy, presumably because it is a cofactor for hydroxylases required for post-translational modifications that stabilize collagen.... | [
"The epithelial inward rectifier channel Kir7.1 displays unusual K+ permeation properties.. Rat and human cDNAs were isolated that both encoded a 360 amino acid polypeptide with a tertiary structure typical of inwardly rectifying K+ channel (Kir) subunits. The new proteins, termed Kir7.1, were <37% identical to oth... | 812 | 19799455 | [
"32250572",
"22901758",
"20868160",
"21878751"
] | scientific_claim_retrieval | scientific |
7cf429032f8e278d19ec62b64c1be0bc | mteb/scifact | The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells. | E2F1-3 Switch from Activators in Progenitor Cells to Repressors in Differentiating Cells. In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions to restrict cells from entering S phase by binding and sequestering E2f activators (E2f1, E2f2 and E2f3), which are invariably por... | [
"Anaphase catastrophe is a target for cancer therapy.. Neoplastic cells are genetically unstable. Strategies that target pathways affecting genome instability can be exploited to disrupt tumor cell growth, potentially with limited consequences to normal cells. Chromosomal instability (CIN) is one type of genome ins... | 1188 | 4394817 | [
"30658796",
"13944805",
"22150633",
"1196631"
] | scientific_claim_retrieval | scientific |
531e5ff35b2d3fbd8b8e7e1147628197 | mteb/scifact | Active H. pylori urease has a polymeric structure consisting of five distinct subunits. | Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori. Half the world's population is chronically infected with Helicobacter pylori, causing gastritis, gastric ulcers and an increased incidence of gastric adenocarcinoma. Its proton-gated inner-membrane urea channel, HpUreI, is essenti... | [
"A minimal Tat system from a gram-positive organism: a bifunctional TatA subunit participates in discrete TatAC and TatA complexes.. The Tat system transports folded proteins across bacterial and thylakoid membranes. In Gram-negative organisms, a TatABC substrate-binding complex and separate TatA complex are believ... | 74 | 4387784 | [
"24706198",
"25657127",
"14155726",
"38805486"
] | scientific_claim_retrieval | scientific |
25ba6e2d33650de509075bb89464a00e | mteb/scifact | Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC) | ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants of AR overexpression in CRPC are poorly defined. Here we s... | [
"Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ. BACKGROUND Colorectal cancer remains one of the most common malignant tumors worldwide. Colorectal cancer initiating cells (CCICs) are a small subpopulation responsible for malignant behaviors of colorectal cancer... | 1043 | 17671145 | [
"3590806",
"37256966",
"14706752",
"17648235"
] | scientific_claim_retrieval | scientific |
84da34ff616b887cc3b3960993333279 | mteb/scifact | Insulin effects appetite via ventral tegmental neurons. | Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis.. Dopaminergic midbrain neurons integrate signals on food palatability and food-associated reward into the complex control of energy homeostasis. To define the role of insulin receptor (IR) signaling in this circuitry, we inactivat... | [
"Metformin—mode of action and clinical implications for diabetes and cancer. Metformin has been the mainstay of therapy for diabetes mellitus for many years; however, the mechanistic aspects of metformin action remained ill-defined. Recent advances revealed that this drug, in addition to its glucose-lowering action... | 643 | 15535511 | [
"13466622",
"36357627",
"14419116",
"9315213"
] | scientific_claim_retrieval | scientific |
db5e7f2df2c9f5a5f90dd9b5e207f786 | mteb/trec-covid | What is the protein structure of the SARS-CoV-2 spike? | Transmission electron microscopy imaging of SARS-CoV-2 | [
"Remdesivir, the antiviral hope against SARS-CoV-2/ Remdesivir, la esperanza antiviral frente al SARS-CoV-2. On December 31, 2019 a pneumonia outbreak caused by a new coronavirus (SARS-CoV-2) was detected in the city of Wuhan (China) Due to the high capacity of diffusion and human infection it has become a new zoon... | 36 | qet66s3d | [
"puc13jf1",
"qi9ex3l5",
"2qiy1glv",
"754nln40"
] | biomedical_literature_retrieval | scientific |
b5abe2387e5bf32ae1779f5332a1f0a8 | mteb/trec-covid | what are the benefits and risks of re-opening schools in the midst of the COVID-19 pandemic? | COVID-19 in the USA: a question of time | [
"On pandemics and the duty to care: whose duty? who cares?. BACKGROUND: As a number of commentators have noted, SARS exposed the vulnerabilities of our health care systems and governance structures. Health care professionals (HCPs) and hospital systems that bore the brunt of the SARS outbreak continue to struggle w... | 48 | khpkpzsj | [
"58czem0j",
"zhw8vh3e",
"upya9ehz",
"3emzk5by"
] | biomedical_literature_retrieval | scientific |
18f9ca234fe4f0efcb12f4be8bcbccbb | mteb/scifact | Specialized functional cell types can be derived from human pluripotent stem cells. | Complex Tissue and Disease Modeling using hiPSCs.. Defined genetic models based on human pluripotent stem cells have opened new avenues for understanding disease mechanisms and drug screening. Many of these models assume cell-autonomous mechanisms of disease but it is possible that disease phenotypes or drug responses ... | [
"Generation of induced pluripotent stem cells from Asian patients with chronic neurodegenerative diseases.. Induced pluripotent stem (iPS) cells derived from disease patients are an invaluable resource for biomedical research and may provide a source for replacement therapies. In this study, we have generated iPS c... | 1096 | 29638116 | [
"35777860",
"4405194",
"4380451",
"37722384"
] | scientific_claim_retrieval | scientific |
172a2de7bd08df3a824a0fac1b80300f | mteb/trec-covid | are cardiac complications likely in patients with COVID-19? | Protein degradation systems in viral myocarditis leading to dilated cardiomyopathy. The primary intracellular protein degradation systems, including the ubiquitin-proteasome and the lysosome pathways, have been emerging as central regulators of viral infectivity, inflammation, and viral pathogenicity. Viral myocarditis... | [
"Demographic profile and outcome analysis of a tertiary level pediatric intensive care unit. Objective : To study the profile and outcome of children admitted to a tertiary level pediatric intensive care unit (PICU) in India.Methods : Prospective study of patient demographics, PRISM III scores, diagnoses, treatment... | 22 | 15c85zi4 | [
"18dxcn41",
"zhw8vh3e",
"1ddfywfa",
"5yt1cgkx"
] | biomedical_literature_retrieval | scientific |
80594a3a33385f45e96aa3b42d270fad | mteb/scifact | Treatment with a protein named FN impairs regenerative abilities of aged muscles. | Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice. Age-related changes in the niche have long been postulated to impair the function of somatic stem cells. Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantially reduced lev... | [
"A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.. Eukaryotes have numerous checkpoint pathways to protect genome fidelity during normal cell division and in response to DNA damage. Through a screen for G2/M checkpoint regulators in zebrafish, we identified ticrr (for TopBP1-interacti... | 1323 | 19912367 | [
"5273056",
"9899292",
"23974474",
"4407385"
] | scientific_claim_retrieval | scientific |
2e59ec5b49537e8cc8f1ce48d3607008 | mteb/trec-covid | which biomarkers predict the severe clinical course of 2019-nCOV infection? | Brain natriuretic peptide to predict successful liberation from mechanical ventilation in critically ill patients: a systematic review and meta-analysis. BACKGROUND: Predicting successful liberation from mechanical ventilation (MV) in critically ill patients is challenging. Brain natriuretic peptide (BNP) has been prop... | [
"Post-ARDS pulmonary fibrosis in patients with H1N1 pneumonia: role of follow-up CT. PURPOSE: Our aim was to evaluate the evolution of 20 patients with H1N1 pneumonia, focusing our attention on patients with severe clinical and radiological findings who developed post-acute respiratory distress syndrome (post-ARDS)... | 25 | vsc50fxx | [
"auqw6l69",
"295i2q8v",
"fn3ehf2a",
"d8sid7gd"
] | biomedical_literature_retrieval | scientific |
4183f757bf132e7bf1e705204c84570a | mteb/scifact | Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding. | Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation. How oncogenic signalling coordinates glycolysis and anabolic biosynthesis in cancer cells remains unclear. We recently reported that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) regulates anabolic... | [
"The non-catalytic function of XPG protein during dual incision in human nucleotide excision repair.. XPG is a member of the FEN-1 structure-specific endonuclease family. It has 3'-junction cutting activity on bubble substrates and makes the 3'-incision in the human dual incision (excision nuclease) repair system. ... | 377 | 18810195 | [
"36855703",
"25942757",
"8570478",
"39389082"
] | scientific_claim_retrieval | scientific |
16589db97b4decb0e00328146ad247cf | mteb/scifact | Recognition of start codons depends on the translation initiation factor IF3. | Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation. In bacterial translational initiation, three initiation factors (IFs 1-3) enable the selection of initiator tRNA and the start codon in the P site of the 30S ribosomal subunit. Here, we report 11 single-particle cryo-electron microscopy (cry... | [
"Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3.. The small ribosomal subunit is responsible for the decoding of genetic information and plays a key role in the initiation of protein synthesis. We analyzed by X-ray crystallography the structures of three different c... | 1023 | 16927286 | [
"23342686",
"23604601",
"41337677",
"30261663"
] | scientific_claim_retrieval | scientific |
4ee899c43b31232e9d3137715418e30c | mteb/scifact | British female students are bullied more than British male students. | Bullying in school: are short pupils at risk? Questionnaire study in a cohort.. Bullying is still prevalent in schools and is clearly stressful for victims. 1 2 It may also have undesirable consequences for bullies, with antisocial behaviour persisting into adulthood. Victims are generally reported to be weaker than th... | [
"Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome. BACKGROUND A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women. We explored the role of the Y chromosome in coronary artery diseas... | 186 | 16855829 | [
"2867345",
"34760396",
"13702924",
"25806385"
] | scientific_claim_retrieval | scientific |
d77d3f0b4866dbf14efd2045902235bb | mteb/scifact | Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods. | Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell. Pluripotent mouse embryonic stem (ES) cells multiply in simple monoculture by symmetrical divisions. In vivo, however, stem cells are generally thought to depend on specialised cellular microenvironments and to undergo predominantly asymmetric ... | [
"Osteoclast nuclei of myeloma patients show chromosome translocations specific for the myeloma cell clone: a new type of cancer-host partnership?. A major clinical manifestation of bone cancers is bone destruction. It is widely accepted that this destruction is not caused by the malignant cells themselves, but by o... | 989 | 9988425 | [
"38793927",
"33955641",
"39532074",
"503050"
] | scientific_claim_retrieval | scientific |
17634f94d8d0551d9bb1caf9e69e6015 | mteb/trec-covid | what type of hand sanitizer is needed to destroy Covid-19? | Inhibitory Effect and Possible Mechanism of Action of Patchouli Alcohol against Influenza A (H2N2) Virus. In the present study, the anti-influenza A (H2N2) virus activity of patchouli alcohol was studied in vitro, in vivo and in silico. The CC(50) of patchouli alcohol was above 20 µM. Patchouli alcohol could inhibit in... | [
"Airspace-Occupying Diseases. Diseases of the air space of the lung share many common findings and presentation that it makes more sense to be grouped together in a differential diagnosis. The common imaging finding is usually as a lung infiltrate or consolidation of some type of distribution or another. Trying to ... | 19 | zhauwxye | [
"1ses23oz",
"vmcy38wt",
"mmd8ru3r",
"aet9nitv"
] | biomedical_literature_retrieval | scientific |
6cd95783db81fd2dc1e7645bbeaabb9f | mteb/scifact | De novo assembly of sequence data has fewer specific contigs than unassembled sequence data. | A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-toxigenic Escherichia coli O104:H4.. IMPORTANCE Identification of the bacterium responsible for an outbreak can aid in disease management. However, traditional culture-based diagnosis can be difficult, particularly i... | [
"Human artificial chromosomes with alpha satellite-based de novo centromeres show increased frequency of nondisjunction and anaphase lag.. Human artificial chromosomes have been used to model requirements for human chromosome segregation and to explore the nature of sequences competent for centromere function. Norm... | 310 | 6173523 | [
"25041967",
"32770503",
"14652521",
"14185503"
] | scientific_claim_retrieval | scientific |
7f10da05e31e4638cbb6a53042b4c2a1 | mteb/scifact | Transcription rates in S. cerevisiae range between 7 and 12 kb/min. | Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo.. A number of proteins and drugs have been implicated in the process of transcriptional elongation by RNA polymerase (Pol) II, but the factors that govern the elongation rate (nucleotide additions per min) and processivit... | [
"Spatial and temporal heterogeneity of Anopheles mosquitoes and Plasmodium falciparum transmission along the Kenyan coast.. The seasonal dynamics and spatial distributions of Anopheles mosquitoes and Plasmodium falciparum parasites were studied for one year at 30 villages in Malindi, Kilifi, and Kwale Districts alo... | 1315 | 13072112 | [
"8373753",
"18537148",
"323335",
"3462075"
] | scientific_claim_retrieval | scientific |
4bc8719927427bf70c5d413c75e2e8d0 | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | The Role of Astrocytes, Microglia, and Endothelial Cells in Coronavirus-Induced Demyelination: Induction of cytokines and other signaling mechanisms. Infection of neurotropic strains of coronaviruses in susceptible animals results in acute encephalomyelitis followed by a chronic demyelinating disease, similar to multip... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | 0urt7axu | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
e488359cd5a3df7cbc75d7b864ff11a1 | mteb/scifact | NR5A2 is important in reverse cholesterol transport in humans. | Liver receptor homolog-1 is essential for pregnancy. Successful pregnancy requires coordination of an array of signals and factors from multiple tissues. One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism and hormone synthesis. It is strongly expressed in granulo... | [
"Apolipoprotein E and atherosclerosis: beyond lipid effect.. In humans, apolipoprotein E (apoE) is a polymorphic multifunctional protein.1 It is coded by three alleles (e2, e3, e4) of a modulator gene (level, variability, and susceptibility gene) at the apoE locus on chromosome 19, determining six apoE genotypes an... | 838 | 15928989 | [
"18852643",
"23286603",
"45166582",
"23460562"
] | scientific_claim_retrieval | scientific |
211ba8b99af11bd5f3af41c1d17b2ffa | mteb/scifact | Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments. | Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis. BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas. We analy... | [
"Rapid DNA methylation changes after exposure to traffic particles.. RATIONALE Exposure to particulate air pollution has been related to increased hospitalization and death, particularly from cardiovascular disease. Lower blood DNA methylation content is found in processes related to cardiovascular outcomes, such a... | 336 | 2097256 | [
"42387637",
"8665891",
"18914652",
"22414304"
] | scientific_claim_retrieval | scientific |
44368098987a0f7abff17eee17970603 | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Interest of a simple on-line screening registry for measuring ICU burden related to an influenza pandemic. INTRODUCTION: The specific burden imposed on Intensive Care Units (ICUs) during the A/H1N1 influenza 2009 pandemic has been poorly explored. An on-line screening registry allowed a daily report of ICU beds occupan... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | l9862er0 | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
1837eda2d36a18d79a3bb2c58b6f20f7 | mteb/scifact | Major vault protein regulates sorting of tumor suppressive miR-193a into EVs. | MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Exosomes are emerging mediators of intercellular communication; whether the release of exosomes has an effect on the exosome donor cells in addition to the recipient cells has not been investigated to any extent. Here, we examine different exo... | [
"Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages. The tumor microenvironment (TME) plays a prominent role in the growth of tumor cells. As the major inflammatory component of the TME, M2d macrophages are educated by the TME such that they adopt an immunosu... | 752 | 19800147 | [
"164985",
"6669242",
"22185730",
"5254463"
] | scientific_claim_retrieval | scientific |
5aea1b130f2abd9078dcb8cddf139968 | mteb/scifact | Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines. | Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.. Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions bet... | [
"Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzyme.. Endothelin-1 (ET-1) is the predominant endothelin isopeptide generated by the vascular wall and therefore appears to be the most important peptide involved in regulation of cardiova... | 1330 | 14075252 | [
"6397191",
"17223891",
"22889972",
"25726838"
] | scientific_claim_retrieval | scientific |
bf728a64ac90dd91407ae4f6767722d7 | mteb/scifact | Pioneer factor OCT3/4 interacts with major chromatin remodeling factors. | Oct4 links multiple epigenetic pathways to the pluripotency network. Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-renewal, pluripotency, and somatic cell reprogramming. However, limited information is available on Oct4-associated protein complexes and their intrinsic protein-... | [
"GEMC1 is a TopBP1 interacting protein required for chromosomal DNA replication. Many of the factors required for chromosomal DNA replication have been identified in unicellular eukaryotes. However, DNA replication is poorly understood in multicellular organisms. Here, we report the identification of GEMC1 (geminin... | 955 | 2078658 | [
"11922370",
"20420780",
"6525844",
"14191255"
] | scientific_claim_retrieval | scientific |
e23ac9a2ddb5f2f122f883b23e1545b9 | mteb/scifact | Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation. | Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial.. CONTEXT Noninvasive ventilation (NIV) has been associated with lower rates of endotracheal intubation in populations of patients with acute respiratory failure. OBJECTIVE To compar... | [
"Acute respiratory failure in patients with severe community-acquired pneumonia: a prospective randomized evaluation of noninvasive ventilation.. In uncontrolled studies, noninvasive positive pressure ventilation (NPPV) was found useful in avoiding endotracheal intubation in patients with acute respiratory failure ... | 855 | 8190282 | [
"40867854",
"43587663",
"13843341",
"24097933"
] | scientific_claim_retrieval | scientific |
3746a757e89e326ee0f7470b806c4659 | mteb/scifact | ART has no effect on the infectiveness of HIV-positive people. | HIV Treatment as Prevention: Systematic Comparison of Mathematical Models of the Potential Impact of Antiretroviral Therapy on HIV Incidence in South Africa. BACKGROUND Many mathematical models have investigated the impact of expanding access to antiretroviral therapy (ART) on new HIV infections. Comparing results and ... | [
"Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model.. BACKGROUND Roughly 3 million people worldwide were receiving antiretroviral therapy (ART) at the end of 2007, but an estimated 6.7 million were still in need of treatment ... | 60 | 13899137 | [
"374902",
"3981244",
"27449472",
"20188586"
] | scientific_claim_retrieval | scientific |
f9baeb6670afe3c1e75e1f05972eb9ef | mteb/scifact | RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells. | The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.. Medullary thymic epithelial cells (mTECs) establish T cell self-tolerance through the expression of autoimmune regulator (Aire) and peripheral tissue-specific self-antigens. Howeve... | [
"Ablation and regeneration of tolerance-inducing medullary thymic epithelial cells after cyclosporine, cyclophosphamide, and dexamethasone treatment.. Immunosuppressive drugs and cytotoxic chemotherapy agents are designed to kill or suppress autoreactive, alloaggressive, or hyperinflammatory T cells, or disseminate... | 1004 | 2734421 | [
"10162553",
"39128592",
"33030946",
"20568364"
] | scientific_claim_retrieval | scientific |
2258e5b5e59096715e5e6cc79509eeaa | mteb/scifact | Charcoal shows no benefit for acute paraquat poisoning. | Effect of activated charcoal hemoperfusion on renal function in patients with paraquat poisoning.. The present study retrospectively analyzed 19 patients diagnosed with paraquat (PQ) poisoning with the aim to investigate the effect of activated charcoal hemoperfusion on renal function and PQ elimination. The results in... | [
"Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial. BACKGROUND The case-fatality for intentional self-poisoning in the rural developing world is 10-50-fold higher than that in industrialised countries, mostly because of the use of highly toxic pesticides and plants. We therefor... | 246 | 3430789 | [
"12209494",
"24097933",
"19132741",
"33203108"
] | scientific_claim_retrieval | scientific |
f6ef000d6fa46a85e135160673135795 | mteb/scifact | Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA. | the Development of Autoimmune Myocarditis in Mice by an. BACKGROUND Interleukin (IL)-12 exerts a potent proinflammatory effect by stimulating T-helper (Th) 1 responses. This effect is believed to be mediated primarily through the activation of STAT4 and subsequent production of interferon (IFN)-gamma. Methods and Resul... | [
"Thyroid Hormone Receptor Repression Linked to Type I Pneumocyte Associated Respiratory Distress Syndrome. Although the lung is a defining feature of air-breathing animals, the pathway controlling the formation of type I pneumocytes, the cells that mediate gas exchange, is poorly understood. In contrast, the glucoc... | 782 | 8246922 | [
"18414462",
"8133180",
"9784254",
"7155555"
] | scientific_claim_retrieval | scientific |
6c2c48d5bb640d22f232474b5e8ce000 | mteb/scifact | Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases. | Sprouty1 Regulates Reversible Quiescence of a Self-Renewing Adult Muscle Stem Cell Pool during Regeneration. Satellite cells are skeletal muscle stem cells capable of self-renewal and differentiation after transplantation, but whether they contribute to endogenous muscle fiber repair has been unclear. The transcription... | [
"Shc coordinates signals from intercellular junctions and integrins to regulate flow-induced inflammation. Atherosclerotic plaques develop in regions of the vasculature associated with chronic inflammation due to disturbed flow patterns. Endothelial phenotype modulation by flow requires the integration of numerous ... | 418 | 16660256 | [
"5821617",
"17188921",
"6717533",
"2593298"
] | scientific_claim_retrieval | scientific |
3b3587252395866825fb6d3f0290da6d | mteb/trec-covid | how does the coronavirus respond to changes in the weather | Evaluating the impact of the weather conditions on the influenza propagation. BACKGROUND: Predicting the details of how an epidemic evolves is highly valuable as health institutions need to better plan towards limiting the infection propagation effects and optimizing their prediction and response capabilities. Simulati... | [
"Network Clustering Revealed the Systemic Alterations of Mitochondrial Protein Expression. The mitochondrial protein repertoire varies depending on the cellular state. Protein component modifications caused by mitochondrial DNA (mtDNA) depletion are related to a wide range of human diseases; however, little is know... | 2 | 4eylgtbc | [
"9egy68c0",
"4cjlolp6",
"7o6htufh",
"upjhmfca"
] | biomedical_literature_retrieval | scientific |
9891c00a70d8cbe8899a05446e31cbf4 | mteb/scifact | Hypothalamic glutamate neurotransmission is unrelated to energy balance. | Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fasting. In the hypothalamic arcuate nucleus (ARC), pro-opiomelanocortin (POMC) neurons inhibit feeding and neuropeptide-Y (NPY) neurons stimulate feeding. We tested whether neurons in the ventromedial hypothalamic nucleus (VMH), a k... | [
"In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus.. The cognitive deficits observed in children with cyanotic congenital heart disease suggest involvement of the developing hippocampus. Chronic postnatal hypoxia present during infancy in these children may play a role... | 541 | 25007443 | [
"14782049",
"4611267",
"4469125",
"46451940"
] | scientific_claim_retrieval | scientific |
6b6ccb39b1c6029c03392c7813d13587 | mteb/scifact | PTEN is a regulator for the transcriptional activity of SRF | Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation. Vascular disease progression is associated with marked changes in vascular smooth muscle cell (SMC) phenotype and function. SMC contractile gene expression and, thus differentiation, is under direct... | [
"Expression of Versican 3′-Untranslated Region Modulates Endogenous MicroRNA Functions. BACKGROUND Mature microRNAs (miRNAs) are single-stranded RNAs that regulate post-transcriptional gene expression. In our previous study, we have shown that versican 3'UTR, a fragment of non-coding transcript, has the ability to ... | 917 | 34071621 | [
"13964633",
"12685434",
"44724517",
"8148304"
] | scientific_claim_retrieval | scientific |
d2db284be1274d280cfd672b10b451e8 | mteb/scifact | CDK6 shows improved binding to loss-of-function variants of p18 INK4C. | Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development. We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18(INK4C) and p16(INK4A) codeletion. Functional reconsti... | [
"Subunit Arrangement and Phenylethanolamine Binding in GluN1/GluN2B NMDA Receptors. Since it was discovered that the anti-hypertensive agent ifenprodil has neuroprotective activity through its effects on NMDA (N-methyl-D-aspartate) receptors, a determined effort has been made to understand the mechanism of action a... | 205 | 7898952 | [
"4425507",
"23698769",
"11557602",
"7717468"
] | scientific_claim_retrieval | scientific |
d8526836e5255f7e92826fd80407c0ea | mteb/scifact | Anthrax spores remain deadly until affected areas are decontaminated. | Secondary aerosolization of viable Bacillus anthracis spores in a contaminated US Senate Office.. CONTEXT Bioterrorist attacks involving letters and mail-handling systems in Washington, DC, resulted in Bacillus anthracis (anthrax) spore contamination in the Hart Senate Office Building and other facilities in the US Cap... | [
"Novel syndromes associated with JC virus infection of neurons and meningeal cells: no longer a gray area.. PURPOSE OF REVIEW The availability of a growing number of immunomodulatory medications over the past few years has been associated with various JC virus (JCV)-associated brain syndromes in patients with autoi... | 116 | 33872649 | [
"13322804",
"30919024",
"46182525",
"11992632"
] | scientific_claim_retrieval | scientific |
4e7ee1a5231685c216f71b192353b4a8 | mteb/scifact | Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling. | Direct sensing of systemic and nutritional signals by hematopoietic progenitors in Drosophila. The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in mammals, proliferate and differentiate into three types of mature cell--plasmatocytes, cr... | [
"TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells.. Human embryonic stem cells (hESCs) self-renew indefinitely and give rise to derivatives of all three primary germ layers, yet little is known about the signaling cascades that govern their pluripotent c... | 346 | 11902109 | [
"26374799",
"25148216",
"43419566",
"21804115"
] | scientific_claim_retrieval | scientific |
163a8c51bfd561754dc1a9bb9705165c | mteb/scifact | Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function. | An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells. Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent cell identity. Whereas the genomic locations of several pluripotency transcription factors have been reported, the spectrum of their interaction partners i... | [
"CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus.. The Insulin-like growth factor 2 (Igf2) and H19 genes are imprinted, resulting in silencing of the maternal and paternal alleles, respectively. This event is dependent upon an imprinted-control region two kilobases upstream of H... | 456 | 30507607 | [
"4421547",
"9159495",
"13958154",
"4418070"
] | scientific_claim_retrieval | scientific |
7c36431750ff3e74bcca6e48d0fe5d78 | mteb/scifact | The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries. | Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. BACKGROUND Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measu... | [
"Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study. BACKGROUND Results of the few cohort studies from countries with low incomes or middle incomes suggest a lower incidence of dementia tha... | 1257 | 581832 | [
"14682243",
"14319754",
"16204011",
"21274919"
] | scientific_claim_retrieval | scientific |
069f9d11900ee2669ded1b0b64ccb844 | mteb/trec-covid | what type of hand sanitizer is needed to destroy Covid-19? | Handwashing with soap and national handwashing projects in Korea: focus on the National Handwashing Survey, 2006-2014. OBJECTIVES: Handwashing is the most fundamental way to prevent the spread of infectious diseases. Correct handwashing can prevent 50 to 70% of water-infections and foodborne-infections. We report the r... | [
"Airspace-Occupying Diseases. Diseases of the air space of the lung share many common findings and presentation that it makes more sense to be grouped together in a differential diagnosis. The common imaging finding is usually as a lung infiltrate or consolidation of some type of distribution or another. Trying to ... | 19 | 5gwnyn8z | [
"1ses23oz",
"vmcy38wt",
"mmd8ru3r",
"aet9nitv"
] | biomedical_literature_retrieval | scientific |
494a6f55f01fd1f48b93a7de1151940b | mteb/scifact | The DESMOND program caused substantial weight loss in most participants. | Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: three year follow-up of a cluster randomised controlled trial in primary care. OBJECTIVE To measure whether the benefits of a single education and self management structured programme ... | [
"Psychological Outcome 4 Years after Restrictive Bariatric Surgery. Extreme obesity is associated with severe psychiatric and somatic comorbidity and impairment of psychosocial functioning. Bariatric surgery is the most effective treatment not only with regard to weight loss but also with obesity-associated illness... | 1156 | 12584053 | [
"43220289",
"34753204",
"7260461",
"4394817"
] | scientific_claim_retrieval | scientific |
89c679d7a7a0053ea8af78edd279e5d8 | mteb/scifact | Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins. | The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins. How individual cells respond to mechanical forces is of considerable interest to biologists as force affects many aspects of cell behaviour. The application of force on integrins triggers cytoskeletal rearrangements and growth of the a... | [
"Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.. Liver X receptors (LXR) are oxysterol-activated nuclear receptors that play a central role in reverse cholesterol transport through up-regulation of ATP-binding cassette transporters (ABCA1 an... | 482 | 10991183 | [
"23286603",
"43880096",
"25606339",
"10530014"
] | scientific_claim_retrieval | scientific |
6f7d2e092db0932167abc94ad582f4bf | mteb/scifact | Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner. | Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation.. Regenerative medicine is predicated on understanding the mechanisms regulating development and applying these conditions to direct stem cell fate. Embryogenesis is guided by cell-cell and cell-matrix interactions, but it is unclear h... | [
"Identification of vitronectin as an extrinsic inducer of cancer stem cell differentiation and tumor formation.. There is mounting evidence that tumors are initiated by a rare subset of cells called cancer stem cells (CSCs). CSCs are generally quiescent, self-renew, form tumors at low numbers, and give rise to the ... | 1102 | 3874000 | [
"13779605",
"21564598",
"2030623",
"5137019"
] | scientific_claim_retrieval | scientific |
e0bcb24f450564f7a2e715d9289c76e7 | mteb/scifact | In the UK, drowning affects boys and girls equally. | Preventing deaths by drowning in children in the United Kingdom: have we made progress in 10 years? Population based incidence study.. Detailed information on drowning in children is not routinely collected by offices of national statistics. Few studies have been carried out in the United Kingdom, and none has been don... | [
"Effect of low doses of ionising radiation in infancy on cognitive function in adulthood: Swedish population based cohort study.. OBJECTIVE To determine whether exposure to low doses of ionising radiation in infancy affects cognitive function in adulthood. DESIGN Population based cohort study. SETTING Sweden. PARTI... | 585 | 42291761 | [
"15678772",
"8428935",
"2575938",
"9167230"
] | scientific_claim_retrieval | scientific |
5d155165a3bc0ea8a50bd84994e6ef72 | mteb/scifact | cSMAC formation represses weak ligand signalling. | The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.. T cell activation is predicated on the interaction between the T cell receptor and peptide-major histocompatibility (pMHC) ligands. The factors that determine the stimulatory potency of a pMHC molecule remain unclea... | [
"Rejuvenation of aged progenitor cells by exposure to a young systemic environment. The decline of tissue regenerative potential is a hallmark of ageing and may be due to age-related changes in tissue-specific stem cells. A decline in skeletal muscle stem cell (satellite cell) activity due to a loss of Notch signal... | 1386 | 306006 | [
"4326318",
"5828251",
"39128592",
"2714623"
] | scientific_claim_retrieval | scientific |
f8fe4f54c91426f8fc268374851a6879 | mteb/scifact | A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo. | HIV–1 Infects Multipotent Progenitor Cells Causing Cell Death and Establishing Latent Cellular Reservoirs. HIV causes a chronic infection characterized by depletion of CD4(+) T lymphocytes and the development of opportunistic infections. Despite drugs that inhibit viral spread, HIV infection has been difficult to cure ... | [
"Persistence of HIV-1 Receptor-Positive Cells after HSV-2 Reactivation: A Potential Mechanism for Increased HIV-1 Acquisition. To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition, we conducted in situ analysis of the cellular infiltrate from sequential biopsies o... | 43 | 7224723 | [
"8563659",
"9988425",
"3173489",
"991139"
] | scientific_claim_retrieval | scientific |
a62aeb282d593d9f6197d4b60cd27fbf | mteb/scifact | A deficiency of vitamin B6 decreases blood levels of homocysteine. | Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering.. BACKGROUND Homocysteine is a risk factor for coronary artery disease (CAD), although a causal relation remains to be proven. The importance of determining direct causality rests in the fact ... | [
"Preventing coronary heart disease: B vitamins and homocysteine.. The list of preventable and reversible risk factors for atherosclerotic cardiovascular disease continues to grow. Cigarette smoking, high blood pressure, physical inactivity, elevated cholesterol, underlying lipoprotein abnormalities, lipoprotein(a),... | 37 | 5152028 | [
"16252863",
"33409100",
"19799455",
"3034412"
] | scientific_claim_retrieval | scientific |
bb34e92977b831823c3b3f93d61f035b | mteb/scifact | Treatment with a protein named FN restores regenerative abilities of aged muscles. | Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice. Age-related changes in the niche have long been postulated to impair the function of somatic stem cells. Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantially reduced lev... | [
"Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains.. Early region 3 (E3) of group C human adenoviruses (Ad) encodes several inhibitors of tumor necrosis factor alpha (TNF-alpha) cytolysis, including an E3 14.... | 1324 | 19912367 | [
"207972",
"4653837",
"1605392",
"39532074"
] | scientific_claim_retrieval | scientific |
a4fa6ca8da68e62b5ba081779c1700e4 | mteb/scifact | Genes involved in pre-mRNA splicing have a significant impact on genome stability. | A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.. Signaling pathways that respond to DNA damage are essential for the maintenance of genome stability and are linked to many diseases, including cancer. Here, a genome-wide siRNA screen was employed to identify addi... | [
"A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication.. Short interfering RNAs (siRNAs) have been used to inhibit HIV-1 replication. The durable inhibition of HIV-1 replication by RNA interference has been impeded, however, by a high mutation ra... | 455 | 12643937 | [
"11784947",
"116075383",
"13771184",
"21373240"
] | scientific_claim_retrieval | scientific |
ff79168a769106888c32df139c352ed7 | mteb/scifact | Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime. | Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study.. CONTEXT The long-term risk for developing hypertension is best described by the lifetime risk statistic. The lifetime risk for hypertension and trends in this risk over time are unknown. OBJECTIVES To estimate ... | [
"The Diabetes Prevention Program: baseline characteristics of the randomized cohort. The Diabetes Prevention Program Research Group.. OBJECTIVE The Diabetes Prevention Program (DPP) is a 27-center randomized clinical trial designed to evaluate the safety and efficacy of interventions that may delay or prevent devel... | 854 | 12206390 | [
"24704139",
"12810152",
"4506414",
"32534305"
] | scientific_claim_retrieval | scientific |
4d3b6f2b7f883bfda80c486adab8d154 | mteb/trec-covid | has social distancing had an impact on slowing the spread of COVID-19? | Can informal social distancing interventions minimize demand for antiviral treatment during a severe pandemic?. BACKGROUND: In the case of a pandemic, individuals may alter their behaviour. A dynamic model incorporating social distancing can provide a mechanism to consider complex scenarios to support decisions regardi... | [
"Practical Considerations When Performing Neurodiagnostic Studies on Patients with COVID-19 and Other Highly Virulent Diseases.. The coronavirus disease 2019, SARS-COV-2 (the cause of COVID-19), has led to a worldwide shortage of personal protective equipment (PPE) and an increased stress on hospital resources, whi... | 10 | 944gun8o | [
"72s8wpla",
"37ojix5j",
"h51zr96k",
"w5fxen70"
] | biomedical_literature_retrieval | scientific |
1a43a55d46970f02a0f353901b6579c9 | mteb/scifact | Improvements in OER catalysts show stable activity over several hundred hours. | Homogeneously dispersed multimetal oxygen-evolving catalysts. Earth-abundant first-row (3d) transition metal–based catalysts have been developed for the oxygen-evolution reaction (OER); however, they operate at overpotentials substantially above thermodynamic requirements. Density functional theory suggested that non-3... | [
"Human artificial chromosomes with alpha satellite-based de novo centromeres show increased frequency of nondisjunction and anaphase lag.. Human artificial chromosomes have been used to model requirements for human chromosome segregation and to explore the nature of sequences competent for centromere function. Norm... | 562 | 20101846 | [
"25041967",
"41928290",
"56391045",
"8692744"
] | scientific_claim_retrieval | scientific |
24a4bc1aef508c95f61b89cd55f79288 | mteb/scifact | Having a main partner improves HIV outcomes. | Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study.. OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patients receiving highly active antiretroviral therapy (HAART). D... | [
"Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury.. OBJECTIVE Hypoproteinemia, fluid retention, and weight gain are associated with development of acute lung injury and mortality in critically ill patients, without proof of cause and effect. We designed a clinical trial to determine... | 495 | 17077004 | [
"13464392",
"24341590",
"5691302",
"2488880"
] | scientific_claim_retrieval | scientific |
29cf136d8e4c592a8043903253b40b3a | mteb/scifact | The risk of cancer rises with level of alcohol consumption. | Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Summary Background Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moder... | [
"Alcohol, wine, and health. Abstract Background: For the past 20 years numerous epidemiological studies have correlated the consumption of alcohol and a variety of disease states: overall mortality, arteriosclerotic vascular diseases, hypertension, cancers, peptic ulcer, respiratory infections, gall stones, kidney ... | 1268 | 52072815 | [
"71625969",
"23967973",
"463533",
"12810152"
] | scientific_claim_retrieval | scientific |
8ea0f4f3744fc075e5c32ccead1719cd | mteb/scifact | Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation. | Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice. BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. It acts... | [
"Atherosclerotic plaque rupture--pathologic basis of plaque stability and instability.. Time for primary reveiw 27 days Atherosclerosis continues to be one of the main subjects in pathology research. The intriguing complexity of its pathogenesis as well as the importance of its clinical sequelae provide a rationale... | 683 | 9315213 | [
"4890578",
"4391121",
"16826810",
"18414462"
] | scientific_claim_retrieval | scientific |
c7100fd77be7c8ed221185d978205721 | mteb/scifact | PrimPol generates short DNA replication intermediates on the leading strand during DNA replication. | hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity.. Prim-pol is a recently identified DNA primase-polymerase belonging to the archaeao-eukaryotic primase (AEP) superfamily. Here, we characterize a previously unrecognized prim-pol in human cells, which we designate hPri... | [
"Topoisomerase II plays an essential role as a swivelase in the late stage of SV40 chromosome replication in vitro.. The effects of topoisomerases I and II on the replication of SV40 DNA were examined using an in vitro replication system of purified proteins that constitutes the monopolymerase system. In the presen... | 970 | 19356271 | [
"11401602",
"15077696",
"2758012",
"16217855"
] | scientific_claim_retrieval | scientific |
a02f0cb8a0a0e4c22dc5c74b726a0ceb | mteb/scifact | Human embryonic stem cells give rise to cell types from all three embryonic germ layers. | Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst.. Somatic cell nuclear transfer (SCNT) technology has recently been used to generate animals with a common genetic composition. In this study, we report the derivation of a pluripotent embryonic stem (ES) cell line (SCNT-hES-1) fr... | [
"Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. The functional heart is comprised of distinct mesoderm-derived lineages including cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse embryo and the mouse embryonic stem cell diffe... | 529 | 10546779 | [
"4427392",
"11335860",
"19770974",
"4325137"
] | scientific_claim_retrieval | scientific |
f1621178633ce144b6d56cf5cf38eca6 | mteb/scifact | British male students are bullied more than British female students. | Bullying in school: are short pupils at risk? Questionnaire study in a cohort.. Bullying is still prevalent in schools and is clearly stressful for victims. 1 2 It may also have undesirable consequences for bullies, with antisocial behaviour persisting into adulthood. Victims are generally reported to be weaker than th... | [
"Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome. BACKGROUND A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women. We explored the role of the Y chromosome in coronary artery diseas... | 187 | 16855829 | [
"2867345",
"25806385",
"13702924",
"24510595"
] | scientific_claim_retrieval | scientific |
bcff4ca574a9efbeb16b56ac3243e8b8 | mteb/trec-covid | what are the benefits and risks of re-opening schools in the midst of the COVID-19 pandemic? | The social benefits of private infectious disease-risk mitigation. Does society benefit from private measures to mitigate infectious disease risks? Since mitigation reduces both peak prevalence and the number of people who fall ill, the answer might appear to be yes. But mitigation also prolongs epidemics and therefore... | [
"On pandemics and the duty to care: whose duty? who cares?. BACKGROUND: As a number of commentators have noted, SARS exposed the vulnerabilities of our health care systems and governance structures. Health care professionals (HCPs) and hospital systems that bore the brunt of the SARS outbreak continue to struggle w... | 48 | wb64oy25 | [
"58czem0j",
"zhw8vh3e",
"upya9ehz",
"3emzk5by"
] | biomedical_literature_retrieval | scientific |
063b020012928764946180884b64e0c6 | mteb/trec-covid | what type of hand sanitizer is needed to destroy Covid-19? | A randomized trial of the efficacy of hand disinfection for prevention of rhinovirus infection.. BACKGROUND Hand disinfection is frequently recommended for prevention of rhinovirus (RV) infection and RV-associated common colds. The effectiveness of this intervention has not been established in a natural setting. The pu... | [
"Airspace-Occupying Diseases. Diseases of the air space of the lung share many common findings and presentation that it makes more sense to be grouped together in a differential diagnosis. The common imaging finding is usually as a lung infiltrate or consolidation of some type of distribution or another. Trying to ... | 19 | zssgqpv7 | [
"1ses23oz",
"vmcy38wt",
"mmd8ru3r",
"aet9nitv"
] | biomedical_literature_retrieval | scientific |
732705db5b1f18b303d876e527381c39 | mteb/scifact | Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development. | Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict. Regulatory T (Treg) cells, whose differentiation and function are controlled by X chromosome-encoded transcription factor Foxp3, are generated in the thymus (tTreg) and extrathymically (peripheral, pTreg), and their def... | [
"Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells.. CD4(+)CD25(+) regulatory T cells (T regs) play a major role in the maintenance of self-tolerance and immune suppression, although the mechanisms controlling T reg development and suppressor... | 435 | 9500590 | [
"41877386",
"5979056",
"3952288",
"24881307"
] | scientific_claim_retrieval | scientific |
0b49df2db1d7fda9b408e2cdb1b0fa17 | mteb/scifact | Pro-inflammatory cytokines are up repressed during tumor development. | Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.. Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions bet... | [
"NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.. The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key pathogenic event. Neu... | 978 | 14075252 | [
"11328820",
"16488405",
"17223891",
"40343416"
] | scientific_claim_retrieval | scientific |
8b6d2b3f4bffd40f6c9b0b43b69984c4 | mteb/scifact | Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites. | Functional Consequences of Splicing of the Antisense Transcript COOLAIR on FLC Transcription. Antisense transcription is widespread in many genomes; however, how much is functional is hotly debated. We are investigating functionality of a set of long noncoding antisense transcripts, collectively called COOLAIR, produce... | [
"Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers.. Transcription factors (TFs) bind specifically to discrete regions of mammalian genomes called cis-regulatory elements. Among those are enhancers, which play key roles in regulation of gene expression during development and diffe... | 262 | 14610165 | [
"2151983",
"39281166",
"29214508",
"39506601"
] | scientific_claim_retrieval | scientific |
45fd3e007d42a4109815e645d9d67993 | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Coherence of Influenza Surveillance Data across Different Sources and Age Groups, Beijing, China, 2008-2015. Influenza is active during the winter and spring in the city of Beijing, which has a typical temperate climate with four clear distinct seasons. The clinical and laboratory surveillance data for influenza have b... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | 8mwblebg | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
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