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36cecaf95097afebd9605e73ca30dc3f | mteb/trec-covid | what are the mortality rates overall and in specific populations | Oral Versus Aerosolized Ribavirin for the Treatment of Respiratory Syncytial Virus Infections in Hematopoietic Cell Transplant Recipients. BACKGROUND: The use of oral ribavirin (RBV) for respiratory syncytial virus (RSV) infections is not well studied. With the drastic increase in the cost of aerosolized RBV, we aimed ... | [
"Health Inequalities, General Trends in Mortality and Morbidity, and Associated Factors. All measures of health status are ultimately derived from observations of individuals. At the field level we have such measures as self-assessed health status, report of a specific disease, record of a particular death, or an i... | 21 | 50xvzmm4 | [
"cqlt5mq2",
"xilenqax",
"9uqa39j9",
"mbeyduzy"
] | biomedical_literature_retrieval | scientific |
344373dbd3fdcc93dbfe293063068c90 | mteb/scifact | The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium. | Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation. Observational clinical and ex vivo studies have established a strong association between atrial fibrillation and inflammation. However, whether inflammation is the cause or the consequence of atrial fibrillation and which specific inflammatory media... | [
"Th2-mediated host protective immunity to intestinal nematode infections.. Despite many years of study, relatively little is known about the effector mechanisms that operate against intestine-dwelling nematodes. Most of the current understanding comes from studies of laboratory model systems in rodents. It is clear... | 1208 | 10284593 | [
"23801039",
"20311968",
"9334631",
"14864285"
] | scientific_claim_retrieval | scientific |
1b18043106f1bfa93b60f24c5edd870b | mteb/scifact | CHOP is a general endoplasmic reticulum stress marker. | Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an importan... | [
"Microtubule-associated histone deacetylase 6 supports the calcium store sensor STIM1 in mediating malignant cell behaviors.. Stromal-interaction molecule 1 (STIM1) is an endoplasmic reticulum Ca(2+) storage sensor that promotes cell growth, migration, and angiogenesis in breast and cervical cancers. Here, we repor... | 209 | 32587939 | [
"2727303",
"20904154",
"35760786",
"42873134"
] | scientific_claim_retrieval | scientific |
172631012d8c9a838858614007e6b18f | mteb/scifact | Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure. | Ultrasound imaging for lumbar punctures and epidural catheterisations: systematic review and meta-analysis.. OBJECTIVE To determine whether ultrasound imaging can reduce the risk of failed lumbar punctures or epidural catheterisations, when compared with standard palpation methods, and whether ultrasound imaging can re... | [
"Application of growth technologies in enhancing food security and sustainability. Anabolic steroids have been widely used in the beef cattle industry for over 50 years as safe and effective growth-promoting agents, and today, more than 90% of all feedlot cattle in the US receive some type of steroidal implant duri... | 1340 | 15482274 | [
"167944455",
"40343416",
"4325398",
"1701063"
] | scientific_claim_retrieval | scientific |
088d6db41951e8e164ef9bbee0043e10 | mteb/scifact | M. stadtmanae induces ASC speck formation in BlaER1 monocytes. | Human Monocytes Engage an Alternative Inflammasome Pathway.. Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this consti... | [
"The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells.. Isorhamnetin is one member of flavonoid components which has been used in the treatment of heart disease. Recently the in vitro anti-cancer effect of isorhamnetin on human esophageal squamous carcinoma cel... | 733 | 34469966 | [
"10218447",
"3531388",
"27022864",
"39763465"
] | scientific_claim_retrieval | scientific |
e5c5a06c6a5eb8b3c9406f845263e28c | mteb/scifact | The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells. | BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks.. The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that BCR/ABL-induced reactive oxygen species (ROSs) cause chronic... | [
"Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia?. Myelodysplastic syndromes (MDS) comprise a heterogeneous group of disorders characterized by ineffective hematopoiesis, with an increased propensity to develop acute myelogenous leuke... | 1261 | 13023410 | [
"5765455",
"21439640",
"6000423",
"6308416"
] | scientific_claim_retrieval | scientific |
f049475260b6fadeaa6c74819a69ddb8 | mteb/scifact | Low expression of miR7a does not repress target genes or exert a biological function in testis. | Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance.. Recent studies have reported that competitive endogenous RNAs (ceRNAs) can act as sponges for a microRNA (miRNA) through their binding sites and that changes in ceRNA abundances from individual genes can modulate the activity ... | [
"Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.. Retinoid receptors (RARs and RXRs) are ligand-activated transcription factors that regulate the transcription of ta... | 714 | 18421962 | [
"23938319",
"22521091",
"9752604",
"8856690"
] | scientific_claim_retrieval | scientific |
999ed64cd3b850acac77093ffe6c4634 | mteb/scifact | Excess gestational weight gain is associated with obesity-related pregnancy outcomes. | Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence. OBJECTIVE To evaluate the effects of dietary and lifestyle interventions in pregnancy on maternal and fetal weight and to quantify the effects of these interventions on obstetric outcomes. DESIGN Syste... | [
"Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies.. OBJECTIVE To assess the effect of 25-hydroxyvitamin D (25-OHD) levels on pregnancy outcomes and birth variables. DESIGN Systematic review and meta-analysi... | 394 | 11360768 | [
"2425364",
"70455704",
"8529693",
"52865789"
] | scientific_claim_retrieval | scientific |
7075e7e4220317f5512831edfdf45e08 | mteb/trec-covid | are there serological tests that detect antibodies to coronavirus? | Development and evaluation of an ELISA using recombinant fusion protein to detect the presence of host antibody to equine arteritis virus. A recombinant glutathione-S-transferase fusion protein expressing amino acids 55–98 of equine arteritis virus (EAV) G(L) (rG(L)55–98) was tested in an ELISA for its ability to detec... | [
"Estimating human-to-human transmissibility of hepatitis A virus in an outbreak at an elementary school in China, 2011. Hepatitis A is caused by hepatitis A virus and occurs worldwide. Estimating the transmissibility, which is usually characterized by the basic reproductive number R(0), the mean number of secondary... | 7 | 7bsixsgd | [
"3nk2ipyi",
"yiqdsf9z",
"h32821u0",
"2hchnlwb"
] | biomedical_literature_retrieval | scientific |
d7f2956b80e87fcc73a4cb357b4ece38 | mteb/scifact | Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine. | Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.. CONTEXT Hyperhomocysteinemia is caused by genetic and lifestyle influences, including low intakes of folate and vitamin B6. However, prospective data relating intake of these vitamins to risk of coronary heart di... | [
"Preventing coronary heart disease: B vitamins and homocysteine.. The list of preventable and reversible risk factors for atherosclerotic cardiovascular disease continues to grow. Cigarette smoking, high blood pressure, physical inactivity, elevated cholesterol, underlying lipoprotein abnormalities, lipoprotein(a),... | 646 | 12810152 | [
"16252863",
"37424881",
"21636085",
"33740844"
] | scientific_claim_retrieval | scientific |
de754c63e2a2f137e8e647c4e32417b1 | mteb/scifact | Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures. | How do I perform a lumbar puncture and analyze the results to diagnose bacterial meningitis?. CONTEXT Diagnostic lumbar punctures (LPs), commonly used to rule out meningitis, are associated with adverse events. OBJECTIVE To systematically review the evidence about diagnostic LP techniques that may decrease the risk of ... | [
"Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virus. Despite widespread use of antiretroviral therapies to control replication of the human immunodeficiency virus (HIV), dysfunctions of cognition that are collecti... | 160 | 52874170 | [
"20471181",
"188911",
"18841257",
"23816832"
] | scientific_claim_retrieval | scientific |
48888e56181b139453b539e75af83610 | mteb/scifact | GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells. | GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry.. Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells. Approximately 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD150(+)CD4... | [
"A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.. Highly regenerative tissues such as blood must possess effective DNA damage responses (DDR) that balance long-term regeneration with protection from leukemogenesis. Hematopoietic stem... | 445 | 10165258 | [
"10015292",
"18489989",
"20186814",
"15728433"
] | scientific_claim_retrieval | scientific |
5b403f30d884cc60308d45bdeb75db7e | mteb/scifact | The predominant localization of Linc00173 is in mononuclear macrophage nuclei. | The non-coding RNA landscape of human hematopoiesis and leukemia. Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions. However, their expression patterns and regulatory functions during normal and malignant human hematopoiesis are incompletely understood. Here we present a comp... | [
"Relationship between Sloan-Kettering virus expression and mouse follicular development. Sloan-Kettering virus gene product (Ski) is an unique nuclear pro-oncoprotein and belongs to the ski/sno proto-oncogene family. Ski plays multiple roles in a variety of cell types, it can induce both oncogenic transformation an... | 1253 | 3321943 | [
"643765",
"26133404",
"3118719",
"10342807"
] | scientific_claim_retrieval | scientific |
4386f6122c3dc9e6b5179b5ee32f0578 | mteb/scifact | Peroxynitrite is required for induction of T cell tolerance. | Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we show here that MDSCs directly disrupt the binding of specific peptide–maj... | [
"TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo. T cell receptor (TCR) ligation is required for the extrathymic differentiation of forkhead box p3(+) (Foxp3(+)) regulatory T cells. Several lines of evidence indicate that weak TCR stimulation favors induction of Foxp3 in the peripher... | 935 | 5483793 | [
"994800",
"25726838",
"18429416",
"24069089"
] | scientific_claim_retrieval | scientific |
8390ac6d3e4a43cd8eeeae8a0bd8e56e | mteb/scifact | The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease. | Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway. The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on a patient's life but i... | [
"Apolipoprotein E4 as a predictor of outcomes in pediatric mild traumatic brain injury.. The epsilon4 allele of the apolipoprotein E (APOE) gene has been linked to negative outcomes among adults with traumatic brain injury (TBI) across the spectrum of severity, with preliminary evidence suggesting a similar pattern... | 1231 | 13905670 | [
"24906548",
"4505748",
"6128334",
"18174210"
] | scientific_claim_retrieval | scientific |
1787af8d50267900466c33a868c6fba0 | mteb/scifact | Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus. | Surgical vs nonsurgical treatment of adults with displaced fractures of the proximal humerus: the PROFHER randomized clinical trial.. IMPORTANCE The need for surgery for the majority of patients with displaced proximal humeral fractures is unclear, but its use is increasing. OBJECTIVE To evaluate the clinical effective... | [
"Risk factors for the development of gallstone recurrence following medical dissolution. The British-Italian Gallstone Study Group.. OBJECTIVE To assess risk factors for gallstone recurrence following non-surgical treatment. DESIGN A prospective follow-up of a multicentre cohort of post-dissolution gallstone patien... | 1115 | 44048701 | [
"40343416",
"19532163",
"11117498",
"8042158"
] | scientific_claim_retrieval | scientific |
c0d0294805dc753a8cf055c17dd15626 | mteb/scifact | Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro. | Generation of Genetically Modified Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells. Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, succes... | [
"Derivation of novel human ground state naive pluripotent stem cells. Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small ... | 111 | 13513790 | [
"4462419",
"4416964",
"13777138",
"27588420"
] | scientific_claim_retrieval | scientific |
be8e67b19ab858da436f455b3112fc30 | mteb/scifact | Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver. | Origin and functions of tissue macrophages.. Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not from circulating monocytes. Each tissue has its own co... | [
"A lineage of myeloid cells independent of Myb and hematopoietic stem cells.. Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive... | 89 | 22406695 | [
"22973574",
"12827098",
"279052",
"9076196"
] | scientific_claim_retrieval | scientific |
5f0169973c996d7345fd183a3e116f24 | mteb/scifact | Ca2+ cycling controls whole-body energy homeostasis in beige fat. | UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent ... | [
"AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System. The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeostasis, which acts to restore energy homoeostasis whenever cellular energy charge is depleted. Over the last 2... | 220 | 19205437 | [
"1590744",
"11238784",
"12994780",
"25050364"
] | scientific_claim_retrieval | scientific |
ae8d1b19158f4bbd3a36deef6fa01a73 | mteb/scifact | Pioneer factor OCT3/4 interacts with major chromatin remodeling factors. | An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells. Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent cell identity. Whereas the genomic locations of several pluripotency transcription factors have been reported, the spectrum of their interaction partners i... | [
"GEMC1 is a TopBP1 interacting protein required for chromosomal DNA replication. Many of the factors required for chromosomal DNA replication have been identified in unicellular eukaryotes. However, DNA replication is poorly understood in multicellular organisms. Here, we report the identification of GEMC1 (geminin... | 955 | 30507607 | [
"11922370",
"20420780",
"6525844",
"14191255"
] | scientific_claim_retrieval | scientific |
5ef0c587e02d81679a988627724a521a | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | Comparison of risk factors for viral and nonviral asthma exacerbations | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | cmqo0nkb | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
66cc9bd68fc774f027620599518202fa | mteb/scifact | HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI. | Diagnostic accuracy of single baseline measurement of Elecsys Troponin T high-sensitive assay for diagnosis of acute myocardial infarction in emergency department: systematic review and meta-analysis. OBJECTIVE To obtain summary estimates of the accuracy of a single baseline measurement of the Elecsys Troponin T high-s... | [
"Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all?. Although a moderate-sized patent ductus arteriosus (PDA) needs to be closed by the time a child is 1-2 years old, there is great uncertainty about whether it needs to be closed during the neonatal period. Al... | 494 | 34873974 | [
"25612629",
"10883736",
"750781",
"14973286"
] | scientific_claim_retrieval | scientific |
d3bc616e4a78910211d2acec0a741fe5 | mteb/scifact | Varying expression levels of EBI2 affect the positioning and migration of B cells. | Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses.. Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. This is achieved by the generation of spatially distinct extrafollicular plasmablast and follicular germinal center (GC... | [
"Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses.. Humoral immune responses depend on B cells encountering antigen, interacting with helper T cells, proliferating and differentiating into low-affinity plasma cells or, after organizing into a germinal center (GC), high... | 1361 | 15488881 | [
"38587347",
"14615911",
"2086909",
"9558539"
] | scientific_claim_retrieval | scientific |
61697f9fa514d02c0671c3fef97034a4 | mteb/scifact | There is no association between HNF4A mutations and diabetes risks. | Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene. Background Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increased rate of macrosomia in the offspring of pregnant women with... | [
"Association between pre-diabetes, type 2 diabetes and trabecular bone score: The Vietnam Osteoporosis Study.. AIMS Trabecular bone score (TBS) is a surrogate indicator of bone microarchitecture. The presenent study sought to examine the association between type 2 diabetes (T2D) and trabecular bone score (TBS) in a... | 1291 | 56893404 | [
"198133135",
"40913091",
"37029185",
"27449472"
] | scientific_claim_retrieval | scientific |
db5f569d94081958d188e41dffe6a992 | mteb/scifact | Chenodeoxycholic acid treatment decreases brown adipose tissue activity. | The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity.. The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can be activated by bile acids, which activate type 2 iodothyro... | [
"Diminished sympathetic nervous system activity in genetically obese (ob/ob) mouse.. The genetically obese (ob/ob) mouse exhibits defective thermoregulatory responses to cold exposure. Pathophysiological explanations for this phenomenon have focused on abnormalities in intracellular metabolism or insensitivity of p... | 250 | 1568684 | [
"25687558",
"17973161",
"21141798",
"24341590"
] | scientific_claim_retrieval | scientific |
8f39552b13665320668331ef36940b15 | mteb/trec-covid | what are the benefits and risks of re-opening schools in the midst of the COVID-19 pandemic? | The Effect of School Closure on Hand, Foot, and Mouth Disease Transmission in Singapore: A Modeling Approach. Singapore implements a school closure policy for institutional hand, foot, and mouth disease (HFMD) outbreaks, but there is a lack of empirical evidence on the effect of closure on HFMD transmission. We conduct... | [
"On pandemics and the duty to care: whose duty? who cares?. BACKGROUND: As a number of commentators have noted, SARS exposed the vulnerabilities of our health care systems and governance structures. Health care professionals (HCPs) and hospital systems that bore the brunt of the SARS outbreak continue to struggle w... | 48 | mkv1jc7u | [
"58czem0j",
"zhw8vh3e",
"upya9ehz",
"3emzk5by"
] | biomedical_literature_retrieval | scientific |
5f5ebe57e551242cfe67b03588f774f7 | mteb/scifact | Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2. | Human papillomavirus and Papanicolaou tests to screen for cervical cancer.. BACKGROUND Screening for cervical cancer based on testing for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or p... | [
"Efficacy of HPV DNA testing with cytology triage and/or repeat HPV DNA testing in primary cervical cancer screening.. BACKGROUND Primary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cervical cells with a Pap test (cytology) has been evaluated in randomized clin... | 972 | 46695481 | [
"6561200",
"16980892",
"76415938",
"46355579"
] | scientific_claim_retrieval | scientific |
ef6bda08bd8f9b7744b03038c1722930 | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | SARS epidemic unmasks age-old quarantine conundrum | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | wj9rnjfn | [
"gqa526yl",
"4y5ofjgt",
"aqv7xhng",
"yo4arwoi"
] | biomedical_literature_retrieval | scientific |
244155bdc4699642a8797f4fe95bc885 | mteb/scifact | The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels. | Modification of kidney barrier function by the urokinase receptor. Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not available. Here we show that induction of ur... | [
"Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion. BACKGROUND Metformin, a widely used hypoglycemic drug, reduces stroke incidence and alleviates chronic inflammation in clinical trials. However, the effect of metformin in ischemic stroke is unclear. Here, we in... | 1215 | 16355392 | [
"3761017",
"14386505",
"30908508",
"4410181"
] | scientific_claim_retrieval | scientific |
0633c92e131fca6327aed1af5dd3db2d | mteb/scifact | ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA. | Pif1 family helicases suppress genome instability at G-quadruplex motifs. The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1 DNA helicase family, which is conserved from bacteria to humans. Here we show that exceptionally potent G-quadruplex unwinding is conserved among Pif1 helicases. Mo... | [
"Regulation and effects of hypothalamic galanin: relation to dietary fat, alcohol ingestion, circulating lipids and energy homeostasis.. Galanin (GAL) is known to stimulate feeding behavior. This peptide has different properties and functions from other feeding stimulants, e.g., neuropeptide Y and agouti-related pr... | 1067 | 4429668 | [
"11742219",
"20851402",
"12207340",
"28193026"
] | scientific_claim_retrieval | scientific |
33016504afc38bbaf920e318c7ff4d59 | mteb/trec-covid | what types of rapid testing for Covid-19 have been developed? | Advances in the diagnosis of respiratory virus infections. Background: Advances have been made in selecting sensitive cell lines for isolation, in early detection of respiratory virus growth in cells by rapid culture assays, in production of monoclonal antibodies to improve many tests such as immunofluorescence detecti... | [
"WHAT CLINICIANS NEED TO KNOW ABOUT ANTIVIRAL DRUGS AND VIRAL RESISTANCE. During the last decade, significant advances have been made in the development and use of antiviral agents for the successful treatment of a number of viral infections.8, 51, 57 An expanding array of antiviral drugs are currently available fo... | 6 | dm21kvnm | [
"6324190r",
"ukqvhzws",
"qyb8er14",
"2ygb80sc"
] | biomedical_literature_retrieval | scientific |
d787d89853cb206fa01542a5fc171858 | mteb/scifact | A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine. | Accelerating Policy Decisions to Adopt Haemophilus influenzae Type b Vaccine: A Global, Multivariable Analysis. BACKGROUND Adoption of new and underutilized vaccines by national immunization programs is an essential step towards reducing child mortality. Policy decisions to adopt new vaccines in high mortality countrie... | [
"Large intestine-targeted nanoparticle-releasing oral vaccine to control genitorectal viral infection. Both rectal and vaginal mucosal surfaces serve as transmission routes for pathogenic microorganisms. Vaccination through large intestinal mucosa, previously proven protective for both of these mucosal sites in ani... | 32 | 12428497 | [
"13764090",
"1970884",
"15435343",
"18261004"
] | scientific_claim_retrieval | scientific |
72ef24d1a16d1075be634cd59654ea6b | mteb/scifact | Lack of FGF21 in mice leads to atherosclerotic plaque formation. | Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice. BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. It acts... | [
"The sheddase ADAM10 is a potent modulator of prion disease. The prion protein (PrP(C)) is highly expressed in the nervous system and critically involved in prion diseases where it misfolds into pathogenic PrP(Sc). Moreover, it has been suggested as a receptor mediating neurotoxicity in common neurodegenerative pro... | 681 | 9315213 | [
"17333231",
"4890578",
"22889972",
"9178310"
] | scientific_claim_retrieval | scientific |
e54ce5754e97c02eb4f3ee1121457e93 | mteb/scifact | Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides. | Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL. Acute lymphoblastic leukemia (ALL) is an aggressive hematological tumor resulting from the malignant transformation of lymphoid progenitors. Despite intensive chemotherapy, 20% of pediatric patients and over 50% of adult ... | [
"Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation.. Macrophages play a relevant role in innate and adaptive immunity depending on the balance of the stimuli received. From an analytical and functional point of view, macrophage stimulation can be segregated in... | 1300 | 6421792 | [
"21626639",
"12315072",
"3831884",
"1574014"
] | scientific_claim_retrieval | scientific |
ffae5fa6546e4ed4fbe6fa323a4cc298 | mteb/scifact | DUSP4 increases apoptosis. | Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance. Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, which c... | [
"Overexpression of the circadian clock gene Bmal1 increases sensitivity to oxaliplatin in colorectal cancer.. PURPOSE The circadian clock gene Bmal1 is involved in cancer cell proliferation and DNA damage sensitivity. The aim of this study was to explore the effect of Bmal1 on oxaliplatin sensitivity and to determi... | 309 | 7821634 | [
"7165938",
"25510546",
"1941721",
"15836115"
] | scientific_claim_retrieval | scientific |
5164a3a7546b09990d418a363b41ea68 | mteb/scifact | TNFAIP3 is a glioblastoma tumor suppressor. | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth. Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets. We d... | [
"Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis. Tumor cells have high-energetic and anabolic needs and are known to adapt their metabolism to be able to survive and keep proliferating under conditions of nutrient stress. We show that PKCζ deficiency promotes the plasticity nece... | 1135 | 33370 | [
"17755060",
"46617075",
"5254463",
"7028976"
] | scientific_claim_retrieval | scientific |
022dc15f3c800f2a5844c66e5e862cd9 | mteb/scifact | p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain | Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor. The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show that n... | [
"Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea: biologic activity and therapeutic implications.. Epigallocatechin-3-gallate (EGCG), a polyphenol extracted from green tea, is an antioxidant with chemopreventive and chemotherapeutic actions. Based on its ability... | 1400 | 14706752 | [
"15563864",
"207972",
"31347396",
"41913714"
] | scientific_claim_retrieval | scientific |
39d784fa2333b337f8416654731a278e | mteb/scifact | CCL19 is a ligand for CCR7. | Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells.. Chemokines orchestrate immune cell trafficking by eliciting either directed or random migration and by activating integrins in order to induce cell adhesion. Analyzing dendritic cell (DC) migration, ... | [
"Chemokine-like receptor 1 (CMKLR1) and chemokine (C-C motif) receptor-like 2 (CCRL2); two multifunctional receptors with unusual properties.. Chemokine-like receptor 1 (CMKLR1), also known as ChemR23, and chemokine (C-C motif) receptor-like 2 (CCRL2) are 7-transmembrane receptors that were cloned in the late 1990s... | 197 | 2177022 | [
"13778710",
"40590358",
"8453819",
"2714623"
] | scientific_claim_retrieval | scientific |
4fb226d6548923c59563b1f562f14d28 | mteb/scifact | Up-regulation of the p53 pathway and related molecular events speeds cancer progression. | Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors. Cells from organisms with renewable tissues can permanently withdraw from the cell cycle in response to diverse stress, including dysfunctional telomeres, DNA damage, strong mitogenic signals, and disrupted chromatin. This response,... | [
"BAX/BAK-independent mitoptosis during cell death induced by proteasome inhibition?. Proteasome inhibitors induce rapid death of cancer cells. We show that in epithelial cancer cells, such death is associated with dramatic and simultaneous up-regulation of several BH3-only proteins, including BIK, BIM, MCL-1S, NOXA... | 1345 | 9559146 | [
"28249680",
"5254463",
"6790197",
"4820792"
] | scientific_claim_retrieval | scientific |
3747c3e0f97300dac265c42913520eb3 | mteb/scifact | A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage. | CRISPR adaptation biases explain preference for acquisition of foreign DNA. CRISPR-Cas (clustered, regularly interspaced short palindromic repeats coupled with CRISPR-associated proteins) is a bacterial immunity system that protects against invading phages or plasmids. In the process of CRISPR adaptation, short pieces ... | [
"Alphavirus-derived small RNAs modulate pathogenesis in disease vector mosquitoes.. Mosquito-borne viruses cause significant levels of morbidity and mortality in humans and domesticated animals. Maintenance of mosquito-borne viruses in nature requires a biological transmission cycle that involves alternating virus ... | 47 | 3512154 | [
"9539248",
"368506",
"1332250",
"26133404"
] | scientific_claim_retrieval | scientific |
fac34c89582289f6b50af18c1376306e | mteb/scifact | Human embryonic stem cells give rise to cell types from all three embryonic germ layers. | Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture.. Embryonic stem (ES) cell lines derived from human blastocysts have the developmental potential to form derivatives of all three embryonic germ layers even after prolonged culture. Here w... | [
"Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. The functional heart is comprised of distinct mesoderm-derived lineages including cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse embryo and the mouse embryonic stem cell diffe... | 529 | 25413327 | [
"4427392",
"11335860",
"19770974",
"4325137"
] | scientific_claim_retrieval | scientific |
c4235362a91525f6be46019cfe07519b | mteb/trec-covid | What are the impacts of COVID-19 among African-Americans that differ from the rest of the U.S. population? | Pandemic Influenza Planning in the United States from a Health Disparities Perspective. We explored how different socioeconomic and racial/ethnic groups in the United States might fare in an influenza pandemic on the basis of social factors that shape exposure, vulnerability to influenza virus, and timeliness and adequ... | [
"Immunosenescence Modulation by Vaccination. A decline in immune function is a hallmark of aging that leads to complicated illness from a variety of infectious diseases, cancer and other immune-mediated disorders, and may limit the ability to appropriately respond to vaccination. How vaccines might alter the senesc... | 41 | qww6pe61 | [
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"htgjwcgs"
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4d76327f7eb30c6310277e94760d51de | mteb/scifact | PD-1 triggering on monocytes enhances IL-10 production by monocytes. | Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Viral replication and microbial translocation from the gut to the blood during HIV infection lead to hyperimmune activation, which contributes to the decline in CD4+ T cell numbers during HIV infection... | [
"Association of Toll-Like Receptor 4 on Human Monocyte Subsets and Vulnerability Characteristics of Coronary Plaque as Assessed by 64-Slice Multidetector Computed Tomography.. BACKGROUND Although Toll-like receptor 4 (TLR-4) is involved in monocyte activation in patients with accelerated forms of atherosclerosis, t... | 902 | 10648422 | [
"3616843",
"34469966",
"7386360",
"623486"
] | scientific_claim_retrieval | scientific |
d78576555d7ef3fc0d15a40b0a347639 | mteb/scifact | HNF4A mutations are associated with macrosomia in infancy. | Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene. Background Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increased rate of macrosomia in the offspring of pregnant women with... | [
"14q deletions are associated with trisomy 12, NOTCH1 mutations and unmutated IGHV genes in chronic lymphocytic leukemia and small lymphocytic lymphoma.. Deletions of the long arm of chromosome 14 [del(14q)] are rare but recurrently observed in mature B-cell neoplasms, particularly in chronic lymphocytic leukemia (... | 490 | 56893404 | [
"42377686",
"24144677",
"11983390",
"7988832"
] | scientific_claim_retrieval | scientific |
3e38e7dfb22d82e47974df599584cfb9 | mteb/scifact | In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs. | Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury. Contusive spinal cord injury leads to a variety of disabilities owing to limited neuronal regeneration and functional plasticity. It is well established that an upregulation of glial-derived chondroitin sulphate proteoglycans (CSPG... | [
"Selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene ORF74.. Open reading frame 74 (ORF74) encoded by human herpesvirus 8 is a highly constitutively active seven transmembrane (7TM) receptor stimulated by angiogenic chemokines, e.g... | 572 | 4447055 | [
"1574014",
"5484763",
"15462523",
"17438862"
] | scientific_claim_retrieval | scientific |
ec6b7cb0052a6d63901cabd1a81555a9 | mteb/scifact | Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments. | Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis. BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas. We analy... | [
"Dengue is still an imported disease in China: a case study in Guangzhou.. Dengue virus and its four serotypes (DENV 1-4) infect approximately 390 million people worldwide each year, with most cases in tropical and subtropical regions. Because of repeated introduction of DENV from epidemic regions and suitable weat... | 337 | 2097256 | [
"8665891",
"11254040",
"121001457",
"8563659"
] | scientific_claim_retrieval | scientific |
1efb9c72599269b029e8f0a7157c6870 | mteb/trec-covid | what are the benefits and risks of re-opening schools in the midst of the COVID-19 pandemic? | Global Pandemics and the Aspiring Plastic Surgery Applicant: Challenges and Potential Solutions | [
"On pandemics and the duty to care: whose duty? who cares?. BACKGROUND: As a number of commentators have noted, SARS exposed the vulnerabilities of our health care systems and governance structures. Health care professionals (HCPs) and hospital systems that bore the brunt of the SARS outbreak continue to struggle w... | 48 | grhfdnkx | [
"58czem0j",
"zhw8vh3e",
"upya9ehz",
"3emzk5by"
] | biomedical_literature_retrieval | scientific |
071ebdbe6982b04f5c0d66af36a1dadc | mteb/scifact | Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities. | Myocardial muscarinic receptor upregulation and normal response to isoproterenol in denervated hearts by familial amyloid polyneuropathy.. BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic neuropathy. The disease usually does not induce heart fai... | [
"Prognostic Value of Late Gadolinium Enhancement Cardiovascular Magnetic Resonance in Cardiac Amyloidosis. BACKGROUND The prognosis and treatment of the 2 main types of cardiac amyloidosis, immunoglobulin light chain (AL) and transthyretin (ATTR) amyloidosis, are substantially influenced by cardiac involvement. Car... | 1112 | 1686881 | [
"13768432",
"6993046",
"2496002",
"28894097"
] | scientific_claim_retrieval | scientific |
ff893abdeeacd9944cd45bdb60830c70 | mteb/scifact | Egr2 regulates the homeostasis of B and T cells. | The Transcription Factors Egr2 and Egr3 Are Essential for the Control of Inflammation and Antigen-Induced Proliferation of B and T Cells. Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. However, the intrinsic mechanisms regulating these responses are unknown. Here, we report... | [
"Krüppel-like factor 2 (KLF2) regulates B-cell reactivity, subset differentiation, and trafficking molecule expression.. The transcription factor Krüppel-like factor 2 (KLF2) is critical for normal trafficking of T lymphocytes, but its role in B cells is unclear. We report that B cell-specific KLF2 deficiency leads... | 370 | 1550937 | [
"32101982",
"14767844",
"1667063",
"40473317"
] | scientific_claim_retrieval | scientific |
2a77824f182f03abbac4c2ff0c3ee4bc | mteb/trec-covid | what are the benefits and risks of re-opening schools in the midst of the COVID-19 pandemic? | Modeling the Impact of Behavior Changes on the Spread of Pandemic Influenza. We use mathematical models to assess the impact of behavioral changes in response to an emerging epidemic. Evaluating the quantitative and qualitative impact of public health interventions on the spread of infectious diseases is a crucial publ... | [
"On pandemics and the duty to care: whose duty? who cares?. BACKGROUND: As a number of commentators have noted, SARS exposed the vulnerabilities of our health care systems and governance structures. Health care professionals (HCPs) and hospital systems that bore the brunt of the SARS outbreak continue to struggle w... | 48 | a7bhno7z | [
"58czem0j",
"zhw8vh3e",
"upya9ehz",
"3emzk5by"
] | biomedical_literature_retrieval | scientific |
eb92c923116b8155553e623f2ad881e0 | mteb/scifact | Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans. | Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO). We demonstrate here that metaboli... | [
"Gut microbial diversity is associated with lower arterial stiffness in women. Aims The gut microbiome influences metabolic syndrome (MetS) and inflammation and is therapeutically modifiable. Arterial stiffness is poorly correlated with most traditional risk factors. Our aim was to examine whether gut microbial com... | 523 | 14803797 | [
"13714201",
"1711571",
"24632480",
"23783727"
] | scientific_claim_retrieval | scientific |
016d76af8c785967b227e9ea2a019cf1 | mteb/scifact | mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes. | Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions. The wobble modification in tRNAs, 5-methoxycarbonylmethyl-2-thiouridine (mcm(5)s(2)U), is required for the proper decoding of NNR codons in eukaryotes. The 2-thio group confers conformational rigidi... | [
"A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast.. Transfer RNAs specific for Gln, Lys, and Glu from all organisms (except Mycoplasma) and organelles have a 2-thiouridine derivative (xm(5)s(2)U) as wobble nucleoside. These tRNAs read the A- and G-ending codons in th... | 1390 | 2890952 | [
"34498325",
"4462139",
"20109325",
"7688110"
] | scientific_claim_retrieval | scientific |
03acbd5c17e8a61d893928694b8d4407 | mteb/trec-covid | What is the mechanism of cytokine storm syndrome on the COVID-19? | T follicular regulatory cells infiltrate the human airways during the onset of acute respiratory distress syndrome and regulate the development of B regulatory cells. T follicular regulatory (Tfr) cell is a CXCR5(+)Foxp3(+) subset of T regulatory (Treg) cell with critical roles in regulating germinal center responses a... | [
"Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion. Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of asymptomatic persistence in recovering survivors is possible, durin... | 39 | 61ezrjuq | [
"32zroj99",
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"hx6lkuj0",
"ts89jxrz"
] | biomedical_literature_retrieval | scientific |
ba8c25e61bf2486a5cd34bc214256928 | mteb/trec-covid | What is the result of phylogenetic analysis of SARS-CoV-2 genome sequence? | Metagenomic Analysis of Fever, Thrombocytopenia and Leukopenia Syndrome (FTLS) in Henan Province, China: Discovery of a New Bunyavirus. Since 2007, many cases of fever, thrombocytopenia and leukopenia syndrome (FTLS) have emerged in Henan Province, China. Patient reports of tick bites suggested that infection could con... | [
"Complete Nucleotide Sequence of Ryegrass Mottle Virus : A New Species of the Genus Sobemovirus. The genome of Ryegrass mottle virus (RGMoV) comprises 4210 nucleotides. The genomic RNA contains four open reading frames (ORFs). The largest ORF 2 encodes a polyprotein of 947 amino acids (103.6 kDa), which codes for a... | 37 | 2p7qrgx0 | [
"n901y2d4",
"4k8f7ou1",
"1dmsh31i",
"02opdk0m"
] | biomedical_literature_retrieval | scientific |
61562240f8b77e94ca8ced4c13e07975 | mteb/scifact | In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus. | Prevention of Rectal SHIV Transmission in Macaques by Daily or Intermittent Prophylaxis with Emtricitabine and Tenofovir. BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission. Pre-exposure prophylaxis (PrEP) with antiret... | [
"Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection.. HIV continues to spread globally, mainly through sexual contact. Despite advances in treatment and care, preventing transmission with vaccines or microbicides has proven difficult. A promising strategy to avoid transmission i... | 584 | 14260013 | [
"708425",
"21274496",
"44737533",
"19327364"
] | scientific_claim_retrieval | scientific |
95fc2daceacdf3754419a3ec8efbd9c6 | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Molecular Basis of a Pandemic of Avian-Type Influenza Virus. Despite heroic efforts to prevent the emergence of an influenza pandemic, avian influenza A virus has prevailed by crossing the species barriers to infect humans worldwide, occasionally with morbidity and mortality at unprecedented levels, and the virus later... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | wu7i548j | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
e86d170d8e8cb70b8f5100749959fd99 | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | Chemokines in acute respiratory distress syndrome. A characteristic feature of all inflammatory disorders is the excessive recruitment of leukocytes to the site of inflammation. The loss of control in trafficking these cells contributes to inflammatory diseases. Leukocyte recruitment is a well-orchestrated process that... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | cbtiwvir | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
2c364ddf1bb3ea237c0c13578c4dfe76 | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Evaluating Symptom Severity of Influenza Viral Infection Using the Influenza Patient-reported Outcomes Instrument (FLU-PRO) in a Healthy Human Challenge Model. BACKGROUND: To apply the validated FLU-PRO scoring method to assess influenza symptom severity in a healthy human challenge model. METHODS: Healthy adults admit... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | 220ur8rw | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
9eb440e7254fd7c8b1c2c6b89b09fd98 | mteb/scifact | ATM and Rad3 related protein have no role in sensing DNA damage. | Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.. Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the ATR checkpoint regulator cause developmental defects in mice ... | [
"Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks.. DNA double-strand breaks (DSBs) are highly hazardous for genome integrity because they have the potential to cause mutations, chromosomal rearrangements and genomic instability. The cellular response to DSBs is orchestrate... | 64 | 40349336 | [
"30122260",
"14178995",
"4688340",
"33036897"
] | scientific_claim_retrieval | scientific |
0dfe1de62599ea4c737ac78606078922 | mteb/scifact | ART has no effect on the infectiveness of HIV-positive people. | Elimination of HIV in South Africa through Expanded Access to Antiretroviral Therapy: A Model Comparison Study. BACKGROUND Expanded access to antiretroviral therapy (ART) using universal test and treat (UTT) has been suggested as a strategy to eliminate HIV in South Africa within 7 y based on an influential mathematica... | [
"Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model.. BACKGROUND Roughly 3 million people worldwide were receiving antiretroviral therapy (ART) at the end of 2007, but an estimated 6.7 million were still in need of treatment ... | 60 | 13901073 | [
"374902",
"3981244",
"27449472",
"20188586"
] | scientific_claim_retrieval | scientific |
a7c555ab8969dca2db338fa2a5d93b3e | mteb/scifact | MeCP2 influences the synaptic maturation of neurons. | Structural Homeostasis: Compensatory Adjustments of Dendritic Arbor Geometry in Response to Variations of Synaptic Input. As the nervous system develops, there is an inherent variability in the connections formed between differentiating neurons. Despite this variability, neural circuits form that are functional and rem... | [
"Increased dendritic complexity and axonal length in cultured mouse cortical neurons overexpressing methyl-CpG-binding protein MeCP2. Rett syndrome is caused by loss-of-function mutations in the gene encoding the methyl DNA-binding factor MeCP2. As brain mass and neuronal complexity tend to be diminished in Rett pa... | 761 | 10009203 | [
"41644178",
"33986200",
"14405193",
"17123316"
] | scientific_claim_retrieval | scientific |
8e4081db915bffa3504153e48dd41f37 | mteb/scifact | Active caspase-11 protein promotes pyroptosis. | Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization.. Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once bacterial molecules are sensed wit... | [
"Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate. Production of Ran-guanosine triphosphate (GTP) around chromosomes induces local nucleation and plus end stabilization of microtubules (MTs). The nuclear protein TPX2 is required for RanGTP-dependent MT nucleation. To... | 79 | 5099266 | [
"2991954",
"4345315",
"56486733",
"33986200"
] | scientific_claim_retrieval | scientific |
759984d2a10567652a8469e738f08a17 | mteb/scifact | G-CSF increases the expansion and infiltration of MDSCs into tumors. | Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation. Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic cancer progression. MDSC regulation is widely variable even among patients harbouring the same type of malignancy, and the mechanisms gov... | [
"IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells.. The role of immune responses in tumor development is a central issue for tumor biology and immunology. IL-17 is an important cytokine for inflammatory and autoimmune dis... | 441 | 2014909 | [
"25726838",
"13778710",
"5395426",
"10486817"
] | scientific_claim_retrieval | scientific |
0f73512dc680f192a401cb5afee86555 | mteb/trec-covid | what is known about those infected with Covid-19 but are asymptomatic? | An Asymptomatic Patient with COVID-19 | [
"Functional community structure of African monodominant Gilbertiodendron dewevrei forest influenced by local environmental filtering. Monodominant patches of forest dominated by Gilbertiodendron dewevrei are commonly found in central African tropical forests, alongside forests with high species diversity. Although ... | 27 | ls6cdive | [
"clirh04i",
"mj63cvwe",
"yc8rjjyf",
"v8lpw4r7"
] | biomedical_literature_retrieval | scientific |
6608bdbb2479d37e9a309cbefe3baf60 | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | N-95 Face Mask for Prevention of Bird Flu Virus: An Appraisal of Nanostructure and Implication for Infectious Control | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | 2ikxxaec | [
"5bwsb265",
"3okytwd8",
"jk7cn1p3",
"pyrfgggz"
] | biomedical_literature_retrieval | scientific |
31c8d6cea056b70a18240639ebba0bd2 | mteb/scifact | Antidepressants increase the severity of migraines. | Tricyclic antidepressants and headaches: systematic review and meta-analysis. OBJECTIVE To evaluate the efficacy and relative adverse effects of tricyclic antidepressants in the treatment of migraine, tension-type, and mixed headaches. DESIGN Meta-analysis. DATA SOURCES Medline, Embase, the Cochrane Trials Registry, an... | [
"Acute kidney injury and chronic kidney disease: an integrated clinical syndrome.. The previous conventional wisdom that survivors of acute kidney injury (AKI) tend to do well and fully recover renal function appears to be flawed. AKI can cause end-stage renal disease (ESRD) directly, and increase the risk of devel... | 119 | 14606752 | [
"23377475",
"26668245",
"8002529",
"26611094"
] | scientific_claim_retrieval | scientific |
e1110a6c869a02f338f147b659f5a9dd | mteb/scifact | Cost effectiveness evaluations based on cRCT data lack external validity. | A Comparison of Cost Effectiveness Using Data from Randomized Trials or Actual Clinical Practice: Selective Cox-2 Inhibitors as an Example. BACKGROUND Data on absolute risks of outcomes and patterns of drug use in cost-effectiveness analyses are often based on randomised clinical trials (RCTs). The objective of this st... | [
"Feasibility assessment of desalination application in Australian traditional agriculture. Abstract Within some data limitations, the paper provides a first assessment of areas in Australia with potential for implementing desalination technologies to supply agricultural water. At the national scale, these areas wer... | 292 | 15048300 | [
"97566194",
"13625993",
"7454794",
"6748318"
] | scientific_claim_retrieval | scientific |
6dc66df72b2a17f0343a36cacc71b774 | mteb/trec-covid | what evidence is there related to COVID-19 super spreaders | Super-spreading events of MERS-CoV infection | [
"Molecular Genetic Insights on Cheetah (Acinonyx jubatus) Ecology and Conservation in Namibia. The extent and geographic patterns of molecular genetic diversity of the largest remaining free-ranging cheetah population were described in a survey of 313 individuals from throughout Namibia. Levels of relatedness, incl... | 14 | lsxg0rrm | [
"xe0xey1n",
"1u44tdrj",
"rjyu8lfl",
"acidfmjc"
] | biomedical_literature_retrieval | scientific |
0f59ad048296a1d8359772faa4e78c46 | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | Bacteria bound to cloth; glucoprotamin; toluidine blue O; surgical helmets versus filtering masks | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | ew41z7wh | [
"5bwsb265",
"3okytwd8",
"jk7cn1p3",
"pyrfgggz"
] | biomedical_literature_retrieval | scientific |
a2b32b9ab2f73fce477142e0b229503a | mteb/scifact | Input from mental and physical health care professionals is not effective at decreasing homelessness. | Mental health problems of homeless children and families: longitudinal study.. OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study. SETTING City of Birmingham. SUBJECTS 58 rehoused families with 103 children aged 2-16 ye... | [
"Mental health difficulties across childhood and mental health service use: findings from a longitudinal population-based study.. BACKGROUND Over the past 20 years the prevalence of child and adolescent mental disorders in high-income countries has not changed despite increased investment in mental health services.... | 638 | 25649714 | [
"73473433",
"43220289",
"8428935",
"73323408"
] | scientific_claim_retrieval | scientific |
b68ec155cd7554b555e4543844c37786 | mteb/scifact | Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake. | The effect of folate fortification on folic acid-based homocysteine-lowering intervention and stroke risk: a meta-analysis.. OBJECTIVE Folate and vitamin B12 are two vital regulators in the metabolic process of homocysteine, which is a risk factor of atherothrombotic events. Low folate intake or low plasma folate conce... | [
"Gene--nutrition interactions in coronary artery disease: correlation between the MTHFR C677T polymorphism and folate and homocysteine status in a Korean population.. INTRODUCTION Elevated plasma total homocysteine is a major risk for coronary artery disease (CAD). Methyltetrahydrofolate reductase (MTHFR) is a main... | 254 | 37424881 | [
"42441846",
"32328114",
"12810152",
"8595678"
] | scientific_claim_retrieval | scientific |
453fac39120240f6bef59a59f9f017e9 | mteb/scifact | Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s. | Prevalence, risk factors, and uptake of interventions for sexually transmitted infections in Britain: findings from the National Surveys of Sexual Attitudes and Lifestyles (Natsal). BACKGROUND Population-based estimates of prevalence, risk distribution, and intervention uptake inform delivery of control programmes for ... | [
"Patterns of chlamydia testing in different settings and implications for wider STI diagnosis and care: a probability sample survey of the British population. BACKGROUND Following widespread rollout of chlamydia testing to non-specialist and community settings in the UK, many individuals receive a chlamydia test wi... | 255 | 5850219 | [
"3413083",
"75636923",
"24510595",
"46277811"
] | scientific_claim_retrieval | scientific |
6388762ce9bd98cee9836715e5e06008 | mteb/scifact | Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models. | Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in lamin A (encoded by LMNA), one of the major architectural elements of the mammalian cell nu... | [
"Hutchinson-Gilford progeria syndrome: review of the phenotype. Hutchinson-Gilford progeria syndrome (HGPS) is a rare but well known entity characterized by extreme short stature, low body weight, early loss of hair, lipodystrophy, scleroderma, decreased joint mobility, osteolysis, and facial features that resemble... | 466 | 22544171 | [
"15692098",
"8995263",
"834336",
"9420732"
] | scientific_claim_retrieval | scientific |
c5e64be34ad4434f29934318c714f42e | mteb/trec-covid | how does the coronavirus respond to changes in the weather | Effect modification of environmental factors on influenza-associated mortality: a time-series study in two Chinese cities. BACKGROUND: Environmental factors have been associated with transmission and survival of influenza viruses but no studies have ever explored the role of environmental factors on severity of influen... | [
"Network Clustering Revealed the Systemic Alterations of Mitochondrial Protein Expression. The mitochondrial protein repertoire varies depending on the cellular state. Protein component modifications caused by mitochondrial DNA (mtDNA) depletion are related to a wide range of human diseases; however, little is know... | 2 | crla8vrj | [
"9egy68c0",
"4cjlolp6",
"7o6htufh",
"upjhmfca"
] | biomedical_literature_retrieval | scientific |
cb05b00f8b56dbf046b7b74daf1dbb38 | mteb/trec-covid | what are the health outcomes for children who contract COVID-19? | The curious case of COVID-19 in children | [
"What is the diagnostic accuracy of single nerve conduction studies and muscle ultrasound to identify critical illness polyneuromyopathy: a prospective cohort study. BACKGROUND: Critical illness polyneuromyopathy (CIPNM) is a major cause of weakness in intensive care unit (ICU) patients, but current diagnostic test... | 47 | 78akrp3u | [
"xtehuzt8",
"j7w5uee2",
"nkr9g0cu",
"qvevfimk"
] | biomedical_literature_retrieval | scientific |
1bb29220ac9a473e72e7841b9bc4de97 | mteb/scifact | Beta-band coherence is enhanced for visible stimuli over invisible stimuli. | Converging Intracranial Markers of Conscious Access. We compared conscious and nonconscious processing of briefly flashed words using a visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten patients. Nonconscious processing of masked words was observed in multiple cortical areas, most... | [
"Discrimination of speech stimuli based on neuronal response phase patterns depends on acoustics but not comprehension.. Speech stimuli give rise to neural activity in the listener that can be observed as waveforms using magnetoencephalography. Although waveforms vary greatly from trial to trial due to activity unr... | 175 | 1710116 | [
"6985854",
"4340358",
"49429882",
"46305977"
] | scientific_claim_retrieval | scientific |
dab777661c706a2ef6348b095c5b05f9 | mteb/scifact | Physical injury represses transgultaminase activity. | Transglutaminase 2 Undergoes a Large Conformational Change upon Activation. Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathogenesis of celiac... | [
"expression by oxidized linoleic. Hypercholesterolemia is associated with impairments in endothelium-dependent vascular relaxations. Paradoxically, endothelial production of nitrogen oxides is increased in early stages of hypercholesterolemia. Prior work has shown that oxidized low density lipoprotein (LDL) has bot... | 949 | 13578199 | [
"15561961",
"3619931",
"16905344",
"5172048"
] | scientific_claim_retrieval | scientific |
52b9285c9a5ef716f1be689304fe9817 | mteb/scifact | The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations. | Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. Viral replication usually requires that innate intracellular lines of defence be overcome, a task usually accomplished by specialized viral gene products. The virion infectivity factor (Vif) protein of human immunodefi... | [
"DNA Deamination Mediates Innate Immunity to Retroviral Infection. CEM15/APOBEC3G is a cellular protein required for resistance to infection by virion infectivity factor (Vif)-deficient human immunodeficiency virus (HIV). Here, using a murine leukemia virus (MLV)-based system, we provide evidence that CEM15/APOBEC3... | 1209 | 4347374 | [
"544971",
"11784947",
"11026600",
"12922760"
] | scientific_claim_retrieval | scientific |
682a79eafec873f170a8a14e293abeeb | mteb/scifact | Normal expression of RUNX1 causes tumorsupressing effects. | Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL. The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse engineering of global transcriptional networks to deciphe... | [
"Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Autoimmune diseases are thought to result from imbalances in normal immune physiology and regulation. Here, we show that autoimmune disease susceptibility and resistance alleles on mouse chromosome 3 (Idd3) correlate with diff... | 858 | 1982286 | [
"13923140",
"26068103",
"8417211",
"1192458"
] | scientific_claim_retrieval | scientific |
035facaea9371d3fc61121d2996a7ebb | mteb/trec-covid | what evidence is there related to COVID-19 super spreaders | The role of hospital environment in transmissions of multidrug-resistant gram-negative organisms. Infections by multidrug-resistant (MDR) Gram-negative organisms (GN) are associated with a high mortality rate and present an increasing challenge to the healthcare system worldwide. In recent years, increasing evidence su... | [
"Molecular Genetic Insights on Cheetah (Acinonyx jubatus) Ecology and Conservation in Namibia. The extent and geographic patterns of molecular genetic diversity of the largest remaining free-ranging cheetah population were described in a survey of 313 individuals from throughout Namibia. Levels of relatedness, incl... | 14 | h5v9ztsy | [
"xe0xey1n",
"1u44tdrj",
"rjyu8lfl",
"acidfmjc"
] | biomedical_literature_retrieval | scientific |
431aea17f16520640afd7b624837e3ee | mteb/scifact | Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2. | BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages. BMP is thought to induce hESC differentiation toward multiple lineages including mesoderm and trophoblast. The BMP-induced trophoblast phenotype is a long-standing paradox in stem... | [
"KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport. We cloned a new member of the murine brain kinesin superfamily, KIF3B, and found that its amino acid sequence is highly homologous but not identical to KIF3A, which we previous... | 401 | 5633876 | [
"1889358",
"1507222",
"24408040",
"32372280"
] | scientific_claim_retrieval | scientific |
3ca1848113d32928b73124b085d78bde | mteb/scifact | siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model. | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth. Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets. We d... | [
"Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer. The myc oncogene is overexpressed in almost half of all breast and ovarian cancers, but attempts at therapeutic interventions against myc have proven to be challenging. Myc regulates multiple biological p... | 1403 | 33370 | [
"19358586",
"28334217",
"27647593",
"3545805"
] | scientific_claim_retrieval | scientific |
b0e7f2937c13f02a9305dc7fc46f76de | mteb/scifact | Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates. | Linking Splicing to Pol II Transcription Stabilizes Pre-mRNAs and Influences Splicing Patterns. RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate that an ... | [
"A coactivator of pre-mRNA splicing.. The nuclear matrix antigen recognized by the monoclonal antibody (mAb) B1C8 is a novel serine (S) and arginine (R)-rich protein associated with splicing complexes and is named here SRm160 (SR-related matrix protein of 160 kD). SRm160 contains multiple SR repeats, but unlike pro... | 963 | 4162857 | [
"10423989",
"30543439",
"16167746",
"16929739"
] | scientific_claim_retrieval | scientific |
fe0a4a8102f2f10eae6f26a60cdeed2e | mteb/trec-covid | what is the origin of COVID-19 | Latest SARS evidence | [
"The use of laparoscopy in abdominal emergencies. Background: The purpose of this article is to describe our experience using laparoscopy in the management of emergent and acute abdominal conditions. Methods: Between March 1997 and November 2001, 277 consecutive minimally invasive procedures were performed for vari... | 1 | 1eytelxn | [
"o0syp1wb",
"hs2vni8z",
"35c6mak0",
"72s8wpla"
] | biomedical_literature_retrieval | scientific |
1bac337e52f2aa9e718d697b905a9f14 | mteb/scifact | Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology. | Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial.. BACKGROUND Human papillomavirus (HPV) testing is known to be more sensitive, but less specific than cytology for detecting cervical intraepithelial neoplasia (C... | [
"Efficacy of HPV DNA testing with cytology triage and/or repeat HPV DNA testing in primary cervical cancer screening.. BACKGROUND Primary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cervical cells with a Pap test (cytology) has been evaluated in randomized clin... | 973 | 27873158 | [
"6561200",
"19140422",
"16980892",
"76415938"
] | scientific_claim_retrieval | scientific |
88dc9e8112291ecf3364246f5ebfd356 | mteb/scifact | Lamins have no effect on nuclear membrane structure maintenance. | Autophagy mediates degradation of nuclear lamina. Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies have focused on autophagic turnover of cytoplasmic material... | [
"Cell death: the significance of apoptosis.. Publisher Summary The classification of cell death can be based on morphological or biochemical criteria or on the circumstances of its occurrence. Currently, irreversible structural alteration provides the only unequivocal evidence of death; biochemical indicators of ce... | 688 | 4452659 | [
"935034",
"18144189",
"20743803",
"207972"
] | scientific_claim_retrieval | scientific |
6225e6bf751790a1796829441df7f7ce | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | Low usage of government healthcare facilities for acute respiratory infections in guatemala: implications for influenza surveillance. BACKGROUND: Sentinel surveillance for severe acute respiratory infections in hospitals and influenza-like illness in ambulatory clinics is recommended to assist in global pandemic influe... | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | qfv8ifvl | [
"gqa526yl",
"4y5ofjgt",
"aqv7xhng",
"yo4arwoi"
] | biomedical_literature_retrieval | scientific |
65beab8729f229e8455b0e611e9fd17f | mteb/scifact | Low nucleosome occupancy correlates with high methylation levels across species. | Dnmt1-Independent CG Methylation Contributes to Nucleosome Positioning in Diverse Eukaryotes. Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their genomes are typically depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines. Here, we extensively survey div... | [
"DNA methylation age of human tissues and cell types. BACKGROUND It is not yet known whether DNA methylation levels can be used to accurately predict age across a broad spectrum of human tissues and cell types, nor whether the resulting age prediction is a biologically meaningful measure. RESULTS I developed a mult... | 717 | 17587795 | [
"7808055",
"15578265",
"23208167",
"9993008"
] | scientific_claim_retrieval | scientific |
3ebcc50a5a410ac5a32dff2bb7cccece | mteb/trec-covid | what evidence is there for the value of hydroxychloroquine in treating Covid-19? | Influenza estacional en adultos y niños—Diagnóstico, tratamiento, quimioprofilaxis y control de brotes institucionales: Guías de práctica clínica de la Sociedad de Enfermedades Infecciosas de Estados Unidos de América. Un Grupo de Expertos de la Sociedad de Enfermedades Infecciosas de los Estados Unidos de América elab... | [
"Urgent intubation without neuromuscular blocking agents and the risk of tracheostomy. Neuromuscular blocking agents play a significant role in improving the success rate for urgent intubation, although there is limited evidence about the effect on subsequent outcomes, such as the incidence of tracheostomy. In this... | 28 | ylv3w9wz | [
"f4rn9m95",
"2bau2dn8",
"d3d1n9qa",
"72s8wpla"
] | biomedical_literature_retrieval | scientific |
6f44ad15081ad644fad5adec97897fd0 | mteb/trec-covid | how long does coronavirus remain stable on surfaces? | Stability of human metapneumovirus and human coronavirus NL63 on medical instruments and in the patient environment | [
"Infections and immunological hazards of allogeneic bone transplantation. Allogeneic transplantation of human cancellous and cortical bone is a controversially discussed concept in trauma and orthopaedic surgery. Biological and immunological arguments support transplantation of autologous material whenever this is ... | 16 | 8ydsyuer | [
"tle1j3xv",
"wuy3cwhu",
"q5cmwzr8",
"mne96c9i"
] | biomedical_literature_retrieval | scientific |
cb8617a2f4ad6751f94329ac74c072f0 | mteb/scifact | The DdrB protein from Deinococcus radiodurans functions as a pentamer. | The structure of DdrB from Deinococcus: a new fold for single-stranded DNA binding proteins. Deinococcus spp. are renowned for their amazing ability to recover rapidly from severe genomic fragmentation as a result of exposure to extreme levels of ionizing radiation or desiccation. Despite having been originally charact... | [
"Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substrates.. Secretion systems require high-fidelity mechanisms to discriminate substrates among the vast cytoplasmic pool of proteins. Factors mediating substrate recognition by the type VI secretion system (T6SS) of Gram-ne... | 1162 | 15305881 | [
"12428814",
"26625002",
"23985464",
"25623469"
] | scientific_claim_retrieval | scientific |
842438a32ca8de5e1f2db3866f653885 | mteb/scifact | Pyridostatin reduces proliferation of homologous recombination - defective cells. | Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds. G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand ... | [
"The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.. BLM, WRN, and p53 are involved in the homologous DNA recombination pathway. The DNA structure-specific helicases, BLM and WRN, unwind Holliday junctions (HJ), an activity that could suppress inappropriate homologous recombination d... | 999 | 16472469 | [
"39637840",
"19522248",
"6710699",
"25838286"
] | scientific_claim_retrieval | scientific |
30b6d51bcd40333293d9660a1269f234 | mteb/scifact | Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines. | Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.. Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions bet... | [
"The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.. NLRP12 is a member of the intracellular Nod-like receptor (NLR) family that has been suggested to downregulate the production of inflammatory cytokines, but its physiological role in regulating inflammation has not been characterized. W... | 1331 | 14075252 | [
"17223891",
"120626",
"21382907",
"45449835"
] | scientific_claim_retrieval | scientific |
5be271368c5ba303e9545559651134ea | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | Critical role of ethics in clinical management and public health response to the West Africa Ebola epidemic. The devastation caused by the Ebola virus disease (EVD) outbreak in West Africa has brought to the fore a number of important ethical debates about how best to respond to a health crisis. These debates include i... | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | cmw0lgpd | [
"gqa526yl",
"4y5ofjgt",
"aqv7xhng",
"yo4arwoi"
] | biomedical_literature_retrieval | scientific |
8b1355dfd7e90047561f6f7ad8616cd4 | mteb/scifact | Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance. | SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.. Chronic feeding on high-calorie diets causes obesity and type 2 diabetes mellitus (T2DM), illnesses that affect hundreds of millions. Thus, understanding the pathways protecting against diet-induced metabolic imbalance is of paramount medical impor... | [
"Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB.. We show that NF-kappaB and transcriptional targets are activated in liver by obesity and high-fat diet (HFD). We have matched this state of chronic, subacute 'inflammation' by low-level activation of NF-kappaB in th... | 778 | 13001323 | [
"31001322",
"14116046",
"10889845",
"5389095"
] | scientific_claim_retrieval | scientific |
6e611aa5d0d57b51e72834145619d40d | mteb/scifact | Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours. | Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease.. CONTEXT Vaso-occlusion is central to the painful crises and acute and chronic organ damage in sickle cell disease. Abnormal nitric oxide-dependent regulation of vascular tone, adhesion, platel... | [
"The effectiveness of right heart catheterization in the initial care of critically ill patients. SUPPORT Investigators.. OBJECTIVE To examine the association between the use of right heart catheterization (RHC) during the first 24 hours of care in the intensive care unit (ICU) and subsequent survival, length of st... | 933 | 14711483 | [
"20746604",
"7873737",
"25816994",
"195317463"
] | scientific_claim_retrieval | scientific |
aaa805f91e8c93e0e181d5e9ea2ce4eb | mteb/scifact | Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension. | Relative effectiveness of clinic and home blood pressure monitoring compared with ambulatory blood pressure monitoring in diagnosis of hypertension: systematic review. OBJECTIVE To determine the relative accuracy of clinic measurements and home blood pressure monitoring compared with ambulatory blood pressure monitorin... | [
"Impact of blood pressure variability on cardiovascular events in elderly patients with hypertension.. Blood pressure variability is one of the characteristic features of hypertension in the elderly. However, its clinical significance remains to be determined. We therefore examined the impact of blood pressure vari... | 106 | 25515907 | [
"54490092",
"22730024",
"15663829",
"3825750"
] | scientific_claim_retrieval | scientific |
6f068b16df5c02943df578c2a5c3ef59 | mteb/trec-covid | How has the COVID-19 pandemic impacted violence in society, including violent crimes? | Trauma Does not Quarantine: Violence During the COVID-19 Pandemic | [
"Practical Considerations When Performing Neurodiagnostic Studies on Patients with COVID-19 and Other Highly Virulent Diseases.. The coronavirus disease 2019, SARS-COV-2 (the cause of COVID-19), has led to a worldwide shortage of personal protective equipment (PPE) and an increased stress on hospital resources, whi... | 43 | uan6rlvo | [
"72s8wpla",
"vggfbym5",
"hs2vni8z",
"sch7zhx7"
] | biomedical_literature_retrieval | scientific |
6a07ea1757b1421d24ddcb5513baeca3 | mteb/scifact | Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms. | The quest to overcome resistance to EGFR-targeted therapies in cancer. All patients with metastatic lung, colorectal, pancreatic or head and neck cancers who initially benefit from epidermal growth factor receptor (EGFR)-targeted therapies eventually develop resistance. An increasing understanding of the number and com... | [
"β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib. INTRODUCTION The overexpression of human epidermal growth factor receptor (HER)-2 in 20% of human breast cancers and its association with aggressive growth has led to widespread use of HER2-targeted therapies, such ... | 227 | 26973393 | [
"4820792",
"9505402",
"86694016",
"24652030"
] | scientific_claim_retrieval | scientific |
942b4d37f6aa144e200c4376799b0f80 | mteb/trec-covid | which SARS-CoV-2 proteins-human proteins interactions indicate potential for drug targets. Are there approved drugs that can be repurposed based on this information? | The SARS Coronavirus receptor ACE 2 A potential target for antiviral therapy | [
"Single-Particle cryo-EM as a Pipeline for Obtaining Atomic Resolution Structures of Druggable Targets in Preclinical Structure-Based Drug Design. Single-particle cryo-electron microscopy (cryo-EM) and three-dimensional (3D) image processing have gained importance in the last few years to obtain atomic structures o... | 29 | bs7vh557 | [
"6m06yzp7",
"njlqgih3",
"mw7athol",
"f089bs8r"
] | biomedical_literature_retrieval | scientific |
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