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The unit distance graph on the three-dimensional integer lattice has a vertex for each lattice point; each vertex has exactly six neighbors. It is possible to remove some of the points from the lattice, so that each remaining point has exactly three remaining neighbors, and so that the induced subgraph of these points ...
3
Analytical Chemistry
The reaction catalyzed by bacterial luciferase is also an oxidative process: * FMNH + O + RCHO → FMN + RCOOH + HO + light In the reaction, molecular oxygen oxidizes flavin mononucleotide and a long-chain aliphatic aldehyde to an aliphatic carboxylic acid. The reaction forms an excited hydroxyflavin intermediate, which ...
1
Biochemistry
Alkaloids are bitter-tasting chemicals, widespread in nature, and often toxic. There are several classes with different modes of action as drugs, both recreational and pharmaceutical. Medicines of different classes include atropine, scopolamine, and hyoscyamine (all from nightshade), the traditional medicine berberine ...
1
Biochemistry
tert-butyl hydroperoxide is potentially dangerous, but explosions are rare. A solution of tert-butyl hydroperoxide and water with a concentration of greater than 90% is forbidden to be shipped according to US Department of Transportation Hazardous Materials Table 49 CFR 172.101. In some sources it also has an NFPA 704 ...
0
Organic Chemistry
Pyridine can be prepared by dealkylation of alkylated pyridines, which are obtained as byproducts in the syntheses of other pyridines. The oxidative dealkylation is carried out either using air over vanadium(V) oxide catalyst, by vapor-dealkylation on nickel-based catalyst, or hydrodealkylation with a silver- or platin...
0
Organic Chemistry
Prismane is a colourless liquid at room temperature. The deviation of the carbon-carbon bond angle from 109° to 60° in a triangle leads to a high ring strain, reminiscent of that of cyclopropane but greater. The compound is explosive, which is unusual for a hydrocarbon. Due to this ring strain, the bonds have a low bo...
4
Stereochemistry
Amyloid precursor protein has been shown to interact with: * APBA1, * APBA2, * APBA3, * APBB1, * APPBP1, * APPBP2, * BCAP31, * BLMH * CLSTN1, * CAV1, * COL25A1, * FBLN1, * GSN, * HSD17B10, and * SHC1. APP interacts with reelin, a protein implicated in a number of brain disorders, including Alzheimer's disease.
1
Biochemistry
Currently, the stability of most ionic liquids under practical electrochemical conditions is unknown, and the fundamental choice of ionic fluid is still empirical as there is almost no data on metal ion thermodynamics to feed into solubility and speciation models. Also, there are no Pourbaix diagrams available, no stan...
8
Metallurgy
Bioconversion, also known as biotransformation, is the conversion of organic materials, such as plant or animal waste, into usable products or energy sources by biological processes or agents, such as certain microorganisms. One example is the industrial production of cortisone, which one step is the bioconversion of p...
2
Environmental Chemistry
FEBS publishes four scientific journals: The FEBS Journal, FEBS Letters, Molecular Oncology and FEBS Open Bio. The FEBS Journal was previously entitled the European Journal of Biochemistry. Molecular Oncology and FEBS Open Bio are open-access journals.
1
Biochemistry
Phase-boundary catalytic (PBC) systems can be contrasted with conventional catalytic systems. PBC is primarily applicable to reactions at the interface of an aqueous phase and organic phase. In these cases, an approach such as PBC is needed due to the immiscibility of aqueous phases with most organic substrate. In PBC,...
7
Physical Chemistry
Antinuclear antibodies (ANAs, also known as antinuclear factor or ANF) are autoantibodies that bind to contents of the cell nucleus. In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins (autoantigens). In some cases, antibodies to human antigens are produ...
1
Biochemistry
The identification of synexpression groups has affected the way some scientists view evolutionary change in higher eukaryotes. Since groups of genes involved in the same biological process often share one or more common control elements, it has been suggested that the differential expression of these synexpression gr...
1
Biochemistry
#Anthocyanin pigments are assembled like all other flavonoids from two different streams of chemical raw materials in the cell: #* One stream involves the shikimate pathway to produce the amino acid phenylalanine, (see phenylpropanoids) #* The other stream produces three molecules of malonyl-CoA, a C unit from a C unit...
3
Analytical Chemistry
In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the promoter. The RNA transcript may encode a protein (mRNA), or can have a function in and of itself, such as tRNA or rRNA. Promoters are located near the transcription st...
1
Biochemistry
Goss specialises in the biosynthesis of natural products at the chemical and genetic level. Goss joined the University of Cambridge in 2000 to study the chemistry and molecular biology of polyketide biosynthesis in the research group of Professors Jim Staunton (FRS) and Peter Leadlay (FRS). She held a one-year teaching...
0
Organic Chemistry
A Norrish type II reaction is the photochemical intramolecular abstraction of a γ-hydrogen (a hydrogen atom three carbon positions removed from the carbonyl group) by the excited carbonyl compound to produce a 1,4-biradical as a primary photoproduct. Norrish first reported the reaction in 1937. Secondary reactions that...
5
Photochemistry
One general form of cell engineering involves altering natural cell production to achieve a more desirable yield or shorter production time. A possible method for changing natural cell production includes boosting or repressing genes that are involved in the metabolism of the product. For example, researchers were able...
1
Biochemistry
Small RNA sequencing can be useful for: * studying the expression profile of miRNA and other small RNAs * increasing the understanding of how cells are regulated or misregulated under pathological conditions * small RNA clustering * novel small RNA discovery * small RNA prediction * differential expression of all s...
1
Biochemistry
Human artificial chromosome may be potentially useful as a gene transfer vectors for gene delivery into human cells, and a tool for expression studies and determining human chromosome function. It can carry very large DNA fragment (there is no upper limit on size for practical purposes), therefore it does not have the ...
1
Biochemistry
Thermobarometry uses equilibrium constants to calculate information about the environmental conditions present during the rocks' formation. While each rock is forming, it reacts with the surrounding elements until it cools down enough to become inert. Each mineral within the rock will cool and crystalize at different p...
9
Geochemistry
In botany, a light curve shows the photosynthetic response of leaf tissue or algal communities to varying light intensities. The shape of the curve illustrates the principle of limiting factors; in low light levels, the rate of photosynthesis is limited by the concentration of chlorophyll and the efficiency of the ligh...
5
Photochemistry
All metal castings experience segregation to some extent, and a distinction is made between macrosegregation and microsegregation. Microsegregation refers to localized differences in composition between dendrite arms, and can be significantly reduced by a homogenizing heat treatment. This is possible because the distan...
7
Physical Chemistry
This process was patented and sold to Hoffmann-La Roche in 1934. The first commercially sold vitamin C product was either Cebion from Merck or Redoxon from Hoffmann-La Roche. Even today industrial methods for the production of ascorbic acid can be based on the Reichstein process. In modern methods however, sorbose is d...
0
Organic Chemistry
(+)-discodermolide has a linear polypropionate backbone, punctuated by Z-olefinic linkages at C(8,9) and C(13,14), a terminal Z-diene substituent at C(21–24), 13 stereogenic centers (including four secondary hydroxyls and seven methyl substituents), a carbamate, and a fully substituted D-lactone. The relative stereoche...
0
Organic Chemistry
Octafluoropropane can be produced either by electrochemical fluorination or by the Fowler process using cobalt fluoride.
2
Environmental Chemistry
In solid-state physics, an orientational glass is a molecular solid in which crystalline long-range order coexists with quenched disorder in some rotational degree of freedom. An orientational glass is either obtained by quenching a plastic crystal, (e.g. cyclohexane, levoglucosan), or it is a mixed crystal in which po...
3
Analytical Chemistry
In organic chemistry, an aldehyde () is an organic compound containing a functional group with the structure . The functional group itself (without the "R" side chain) can be referred to as an aldehyde but can also be classified as a formyl group. Aldehydes are a common motif in many chemicals important in technology a...
0
Organic Chemistry
Malonyl-CoA, in a series of reactions, is further split into acetyl-CoA and glyoxylate. Glyoxylate is incorporated into beta-methylmalyl-coA which is then split, again through a series of reactions, to release pyruvate as well as acetate, which is used to replenish the cycle.
1
Biochemistry
The B-B bond adds across alkenes and alkynes to give the 1,2-diborylated alkanes and alkenes. Using various organorhodium or organoiridium catalysts, it can also be installed onto saturated hydrocarbons: :CH(CH)CH + [pinB] → pinBH + CH(CH)Bpin These reactions proceed via boryl complexes. Bis(pinacolato)diboron can also...
0
Organic Chemistry
We consider a polymer as a chain of monomers, each with its position vector and scattering amplitude . For simplicity, it is worthwhile considering identical monomers in the chain, such that all . An incoming ray (of light/neutrons/X-ray etc.) has a wave vector (or momentum) , and is scattered by the polymer to the ve...
7
Physical Chemistry
In froth flotation, the crushed ore is wetted, suspended in a slurry, and mixed with reagents that render the sulfide particles hydrophobic. Typical reagents ("collectors") include potassium ethylxanthate and sodium ethylxanthate, but dithiophosphates and dithiocarbamates are also used. The slurry is introduced to a wa...
8
Metallurgy
In organosulfur chemistry, a thioketal is the sulfur analogue of a ketal (), with one of the oxygen replaced by sulfur (as implied by the thio- prefix), giving the structure . A dithioketal has both oxygens replaced by sulfur (). Thioketals can be obtained by reacting ketones () or aldehydes () with thiols (). An oxida...
0
Organic Chemistry
In the 1996 report of the method, thin films were coated with yttrium and lanthanum topped with a layer of palladium for the diffusion of hydrogen. The rate of absorption of hydrogen resulted in typical optical properties. In the 2008 report magnesium, titanium and nickel are eroded and sputtering deposited in differen...
3
Analytical Chemistry
Terahertz spectroscopy detects and controls properties of matter with electromagnetic fields that are in the frequency range between a few hundred gigahertz and several terahertz (abbreviated as THz). In many-body systems, several of the relevant states have an energy difference that matches with the energy of a THz ph...
7
Physical Chemistry
The boronic acid organic residue is a nucleophile in conjugate addition also in conjunction with a metal. In one study the pinacol ester of allylboronic acid is reacted with dibenzylidene acetone in such a conjugate addition: :The catalyst system in this reaction is tris(dibenzylideneacetone)dipalladium(0) / tricyclohe...
0
Organic Chemistry
Carbon dioxide in the Earth's atmosphere is essential to life and to most of the planetary biosphere. The average rate of energy capture by photosynthesis globally is approximately 130 terawatts, which is about six times larger than the current power consumption of human civilization. Photosynthetic organisms also conv...
2
Environmental Chemistry
Passive daytime radiative cooling is referred to as more stable, adaptable, and reversible when compared to stratospheric aerosol injection, which proposes injecting particles into the atmosphere to increase radiative forcing to reduce temperatures. Studies have warned against stratospheric aerosol injections potential...
7
Physical Chemistry
An ion trap mass spectrometer may incorporate a Penning trap (Fourier-transform ion cyclotron resonance), Paul trap or the Kingdon trap. The Orbitrap, introduced in 2005, is based on the Kingdon trap. Other types of mass spectrometers may also use a linear quadrupole ion trap as a selective mass filter.
7
Physical Chemistry
* Evaporation * Sublimation * Cracking of alkanes * Thermal decomposition * Hydrolysis * Nucleosynthesis of elements heavier than nickel in stellar cores * High-energy neutrons can produce tritium from lithium-7 in an endothermic process, consuming 2.466 MeV. This was discovered when the 1954 Castle Bravo nuclear test ...
7
Physical Chemistry
*Atkins, P.W. (1978). Physical Chemistry Oxford University Press *Trevor Palmer (2001) Enzymes: biochemistry, biotechnology and clinical chemistry Chichester Horwood Publishing
7
Physical Chemistry
Acid–base homeostasis is the homeostatic regulation of the pH of the body's extracellular fluid (ECF). The proper balance between the acids and bases (i.e. the pH) in the ECF is crucial for the normal physiology of the body—and for cellular metabolism. The pH of the intracellular fluid and the extracellular fluid need ...
7
Physical Chemistry
Linear azole(in)e-containing peptides (LAPs) contain thiazoles and oxazoles, or their reduced thiazoline and oxazoline forms. Thiazol(in)es are the result of cyclization of Cys residues in the precursor peptide, while (methyl)oxazol(in)es are formed from Thr and Ser. Azole and azoline formation also modifies the residu...
1
Biochemistry
The Britton–Robinson buffer (aka BRB aka PEM) is a "universal" pH buffer used for the pH range from 2 to 12. It has been used historically as an alternative to the McIlvaine buffer, which has a smaller pH range of effectiveness (from 2 to 8). Universal buffers consist of mixtures of acids of diminishing strength (incre...
3
Analytical Chemistry
Sekeris was a direct descendant of Panagiotis Sekeris, a merchant and ship owner who lived in Constantinople in the early 19th century and co-founded the Filiki Eteria (a secret society aiming to overthrow the Ottoman rule in Greece), and who spent his entire wealth financing this process. Sekeris married Lioka (Kallio...
1
Biochemistry
There are a number of software tools that can directly compute elasticities and control coefficients: * COPASI (GUI) * PySCeS (Python) * SBW (GUI) * libroadrunner (Python) * VCell
1
Biochemistry
An essential nutrient is a nutrient required for normal physiological function that cannot be synthesized in the body – either at all or in sufficient quantities – and thus must be obtained from a dietary source. Apart from water, which is universally required for the maintenance of homeostasis in mammals, essential nu...
9
Geochemistry
A methylene blue active substances assay, or MBAS assay, is a colorimetric analysis test method that uses methylene blue to detect the presence of anionic surfactants (such as a detergent or foaming agent) in a sample of water. An anionic surfactant detected by the color reaction is called a methylene blue active subst...
3
Analytical Chemistry
The Buchner-Curtius-Schlotterbeck reaction yields ketones from aldehydes and aliphatic diazo compounds: The reaction type is nucleophilic addition.
0
Organic Chemistry
Milky seas (Somali: Kaluunka iftiima; English: Milky seas), also called mareel, is a luminous phenomenon in the ocean in which large areas of seawater (up to ) appear to glow translucently (in varying shades of blue). Such occurrences glow brightly enough at night to be visible from satellites orbiting Earth. Mariners ...
1
Biochemistry
The Egyptians were practicing cire perdue from the mid 3rd millennium BC, shown by Early Dynastic bracelets and gold jewellery. Inserted spouts for ewers (copper water vessels) from the Fourth Dynasty (Old Kingdom) were made by the lost-wax method. Hollow castings, such as the Louvre statuette from the Fayum find appea...
8
Metallurgy
Chloromethane was a widely used refrigerant, but its use has been discontinued. It was particularly dangerous among the common refrigerants of the 1930s due to its combination of toxicity, flammability and lack of odor as compared with other toxic refrigerants such as sulfur dioxide and ammonia. Chloromethane was also ...
2
Environmental Chemistry
Oxygen-17 (O) is a low-abundance, natural, stable isotope of oxygen (0.0373% in seawater; approximately twice as abundant as deuterium). As the only stable isotope of oxygen possessing a nuclear spin (+5/2) and a favorable characteristic of field-independent relaxation in liquid water, O enables NMR studies of oxidativ...
9
Geochemistry
There is an operational blacksmith shop with an operating line shaft setup powered by a 15-horsepower 1917 Mogul gasoline engine. During the show days, there are multiple forges lit, and multiple blacksmiths can be found working pieces of iron into many different things.
8
Metallurgy
The PCR method is extremely sensitive, requiring only a few DNA molecules in a single reaction for amplification across several orders of magnitude. Therefore, adequate measures to avoid contamination from any DNA present in the lab environment (bacteria, viruses, or human sources) are required. Because products from p...
1
Biochemistry
In spectroscopy, an isosbestic point is a specific wavelength, wavenumber or frequency at which the total absorbance of a sample does not change during a chemical reaction or a physical change of the sample. The word derives from two Greek words: "iso", meaning "equal", and "sbestos", meaning "extinguishable".
7
Physical Chemistry
Nearly all materials could be seen as hierarchically structured, since the changes in spatial scale bring about different mechanisms of deformation and damage. However, in biological materials, this hierarchical organization is inherent to the microstructure. One of the first examples of this, in the history of structu...
1
Biochemistry
Polytypes are a special case of polymorphs, where multiple close-packed crystal structures differ in one dimension only. Polytypes have identical close-packed planes, but differ in the stacking sequence in the third dimension perpendicular to these planes. Silicon carbide (SiC) has more than 170 known polytypes, altho...
3
Analytical Chemistry
Serious galvanic corrosion has been reported on the latest US Navy attack littoral combat vessel the USS Independence caused by steel water jet propulsion systems attached to an aluminium hull. Without electrical isolation between the steel and aluminium, the aluminium hull acts as an anode to the stainless steel, resu...
8
Metallurgy
Campbell was born in Waimate on 27 May 1925, the son of Mona Sevicke Campbell (née Jones) and David Brown Campbell. He was educated at Waimate High School, and then proceeded to study chemistry at the University of Otago, graduating Master of Science with second-class honours in 1948, and PhD in 1953. His doctoral the...
3
Analytical Chemistry
The cyclooctane derivative OCT was the first one developed for Cu-free click chemistry; it had only ring strain to drive the reaction forward, and the kinetics were barely improved over the Staudinger ligation. After OCT and MOFO (monofluorinated cyclooctyne), the difluorinated cyclooctyne (DIFO) was developed. An impr...
0
Organic Chemistry
Chloroplasts alone make almost all of a plant cell's amino acids in their stroma except the sulfur-containing ones like cysteine and methionine. Cysteine is made in the chloroplast (the proplastid too) but it is also synthesized in the cytosol and mitochondria, probably because it has trouble crossing membranes to get ...
5
Photochemistry
In humans endoglin may be involved in the autosomal dominant disorder known as hereditary hemorrhagic telangiectasia (HHT) type 1. HHT is actually the first human disease linked to the TGF beta receptor complex. This condition leads to frequent nose bleeds, telangiectases on skin and mucosa and may cause arteriovenous ...
1
Biochemistry
Physicochemical distance is a measure that assesses the difference between replaced amino acids. The value of distance is based on properties of amino acids. There are 134 physicochemical properties that can be used to estimate similarity between amino acids. Each physicochemical distance is based on different composit...
1
Biochemistry
Selected reactivity of diphosphenes is summarized in the following picture, including oxidation, reduction, sulfurization, polymerization, carbene addition, halogenation, photolysis, and coordination to the transition-metal:
0
Organic Chemistry
The Hepatitis C virus requires the CD81 co-receptor for infection. Studies suggest that the tight junction protein Claudin-1 (CLDN1) may also play a part in HCV entry. Claudin family abnormalities are also common in hepatocellular carcinoma, which can result from HPV infection.
1
Biochemistry
Closed fullerenes encapsulating small molecules have been synthesized. Representative are the synthesis of the dihydrogen endofullerene H@C, the water endofullerene HO@C, the hydrogen fluoride endofullerene HF@C, and the methane endofullerene CH@C. The encapsulated molecules display unusual physical properties which ha...
6
Supramolecular Chemistry
Joseph Joshua Weiss (30 August 1905 – 9 April 1972) was a Jewish-Austrian chemist and Professor at the Newcastle University. He was a pioneer in the field of radiation chemistry and photochemistry.
5
Photochemistry
Problems with mRNA stability have been identified in viral genomes, cancer cells, and various diseases. Research shows that many of these problems arise because of faulty ARE function. Some of these problems have been listed below: * The c-fos gene produces a transcription factor that is activated in several cancers, a...
1
Biochemistry
In chemistry, halogenation is a chemical reaction which introduces of one or more halogens into a chemical compound. Halide-containing compounds are pervasive, making this type of transformation important, e.g. in the production of polymers, drugs. This kind of conversion is in fact so common that a comprehensive overv...
0
Organic Chemistry
A common way ordinary consumers are exposed to nitrosamines is through tobacco use and cigarette smoke. Tobacco-specific nitrosamines also can be found in American dip snuff, chewing tobacco, and to a much lesser degree, snus (127.9 ppm for American dip snuff compared to 2.8 ppm in Swedish snuff or snus).
0
Organic Chemistry
Following their development of Au-catalyzed Conia-ene reactions, Toste and coworkers employed such a transformation toward the alkaloid natural product lycopladine A. Starting from chiral cyclohexenone 1, a series of enone functionalizations gave silyl enol ether 2 as the Conia-ene precursor. To effect cyclization, 2 w...
0
Organic Chemistry
Shotgun lipidomics was developed by Richard W. Gross and Xianlin Han, by employing ESI intrasource separation techniques. Individual molecular species of most major and many minor lipid classes can be fingerprinted and quantitated directly from biological lipid extracts without the need for chromatographic purification...
1
Biochemistry
In special relativity, an observer moving with uniform proper acceleration through Minkowski spacetime is conveniently described with Rindler coordinates, which are related to the standard (Cartesian) Minkowski coordinates by The line element in Rindler coordinates, i.e. Rindler space is where , and where is related ...
7
Physical Chemistry
The original sequence is reconstructed from the reads using sequence assembly software. First, overlapping reads are collected into longer composite sequences known as contigs. Contigs can be linked together into scaffolds by following connections between mate pairs. The distance between contigs can be inferred from th...
1
Biochemistry
Oxoammonium cations are isoelectronic with carbonyls and structurally related to aldoximes (hydroxylamines), and aminoxyl (nitroxide) radicals, with which they can interconvert via a series of redox steps. According to X-ray crystallography, the N–O distance in [TEMPO]BF is 1.184 Å, 0.1 Å shorter than the N–O distance ...
0
Organic Chemistry
In 1995 high levels of MTBE were unexpectedly discovered in the water wells of Santa Monica, California, and the U.S. Geological Survey reported detections. Subsequent U.S. findings indicate tens of thousands of contaminated sites in water wells distributed across the country. As per toxicity alone, MTBE is not classif...
2
Environmental Chemistry
Conventional cryoprotectants are glycols (alcohols containing at least two hydroxyl groups), such as ethylene glycol , propylene glycol and glycerol. Ethylene glycol is commonly used as automobile antifreeze; while propylene glycol has been used to reduce ice formation in ice cream. Dimethyl sulfoxide (DMSO) is also re...
1
Biochemistry
* Effects of Pyrazinamide on Fatty Acid Synthesis by Whole Mycobacterial Cells and Purified Fatty Acid Synthase I. Helena I. Boshoff, Valerie Mizrahi, Clifton E. Barry. Journal of Bacteriology, 2002 * The impact of drug resistance on Mycobacterium tuberculosis physiology: what can we learn from rifampicin?. Anastasia K...
1
Biochemistry
The treatment given so far is for a system not subject to an external electric field. When conductivity is measured the system is subject to an oscillating external field due to the application of an AC voltage to electrodes immersed in the solution. Debye and Hückel modified their theory in 1926 and their theory was f...
7
Physical Chemistry
In contrast to most other neuroleptics which block both D and D receptors, levosulpiride is more selective and acts primarily as a D antagonist. Levosulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, and gamma-aminobutyric acid (GABA) receptors.
4
Stereochemistry
* 1941: Isaac Asimov published the science fiction short story "Reason," in which a space station transmits energy collected from the sun to various planets using microwave beams. "Reason" was published in the "Astounding Science Fiction" magazine. *1968: Peter Glaser introduces the concept of a "solar power satellite...
7
Physical Chemistry
Methylmercury is formed from inorganic mercury by the action of microbes that live in aquatic systems including lakes, rivers, wetlands, sediments, soils and the open ocean. This methylmercury production has been primarily attributed to anaerobic bacteria in the sediment. Significant concentrations of methylmercury in ...
0
Organic Chemistry
Though nitrogen fixation is the primary source of plant-available nitrogen in most ecosystems, in areas with nitrogen-rich bedrock, the breakdown of this rock also serves as a nitrogen source. Nitrate reduction is also part of the iron cycle, under anoxic conditions Fe(II) can donate an electron to and is oxidized to ...
1
Biochemistry
Gel electrophoresis of nucleic acids is an analytical technique to separate DNA or RNA fragments by size and reactivity. Nucleic acid molecules are placed on a gel, where an electric field induces the nucleic acids (which are negatively charged due to their sugar-phosphate backbone) to migrate toward the positively cha...
1
Biochemistry
The Sir William Dunn Professorship of Biochemistry is the senior professorship in biochemistry at the University of Cambridge. The position was established in 1914 by the trustees of the will of Sir William Dunn, banker, merchant and philanthropist. The first holder of the chair was Frederick Gowland Hopkins, winner of...
1
Biochemistry
HDAC11 has been shown to be related to HDACs 3 and 8, but its overall sequence is quite different from the other HDACs, leading it to be in its own category. HDAC11 has a catalytic domain located in its N-terminus. It has not been found incorporated in any HDAC complexes such as Nurd or SMRT which means it may have a s...
0
Organic Chemistry
The Dufour effect is the energy flux due to a mass concentration gradient occurring as a coupled effect of irreversible processes, named after L. Dufour. It is the reciprocal phenomenon to the Soret effect. The concentration gradient results in a temperature change. For binary liquid mixtures, the Dufour effect is usu...
7
Physical Chemistry
Some wastes contain chemicals capable of suppressing microbiological growth or activity. Potential sources include industrial wastes, antibiotics in pharmaceutical or medical wastes, sanitizers in food processing or commercial cleaning facilities, chlorination disinfection used following conventional sewage treatment, ...
3
Analytical Chemistry
The structure of Zintl ions can be confirmed through x-ray crystallography. Corbett has also improved the crystallization of Zintl ions by demonstrating the use of chelating ligands such as cryptands, as cation sequestering agents. Many of the main group elements have NMR active nuclei, thus NMR experiments are also va...
7
Physical Chemistry
The Ružička large-ring synthesis or Ružička reaction or Ružička cyclization is an organic reaction in which a dicarboxylic acid is converted to a cyclic ketone via heating with a thorium oxide catalyst. The reaction is named after Lavoslav Ružička, who invented it in 1926. The reaction has been applied in the synthe...
0
Organic Chemistry
In 1998, Andrew Fire at Carnegie Institution for Science in Washington DC and Craig Mello at University of Massachusetts in Worcester discovered the RNAi mechanism while working on the gene expression in the nematode, Caenorhabditis elegans. They won the Nobel prize for their research with RNAi in 2006. siRNAs and thei...
1
Biochemistry
When genotypes grown together in a diverse population have different profiles of resource use they complement each other in the exploitation of the limiting resource and therefore are subject to smaller between-plant competition. In case of disease or environmental change some plants will take over when others fail. Yi...
1
Biochemistry
Chiral molecules have two forms (at each point of asymmetry), which differ in their optical characteristics: The levorotatory form (the (−)-form) will rotate counter-clockwise on the plane of polarization of a beam of light, whereas the dextrorotatory form (the (+)-form) will rotate clockwise on the plane of polarizati...
4
Stereochemistry
Triazenes derived from primary amines engage in tautomerism. In the case of symmetric triazenes, the tautomers are identical. Triazenes can be converted to diazonium salts. Triazenes decompose in the presence of protonating or alkylating agents into quaternary amines and diazonium salts; as such triazenes have been u...
0
Organic Chemistry
From early studies an initial model of PDE, active site topography was derived. This early model can be summarized into the following steps concerning cAMP active site topography: # cAMP substrate with its adenine and ribose moieties in an "anti" relationship # The phosphate atom in cAMP binds to PDE active site, using...
1
Biochemistry
Leaves in temperate, boreal, and seasonally dry zones may be seasonally deciduous (falling off or dying for the inclement season). This mechanism to shed leaves is called abscission. When the leaf is shed, it leaves a leaf scar on the twig. In cold autumns, they sometimes change color, and turn yellow, bright-orange, o...
5
Photochemistry
Supramolecular complexes are held together by hydrogen bonding, hydrophobic forces, van der Waals forces, π-π interactions, and electrostatic effects, all of which can be described as noncovalent bonding. Applications include molecular recognition, host–guest chemistry and anion sensors. A typical application in molecu...
7
Physical Chemistry
Phytoplankton supports all life in the ocean as it converts inorganic compounds into organic constituents. This autotrophically produced biomass presents the foundation of the marine food web. In the diagram immediately below, the arrows indicate the various production (arrowhead pointing toward DOM pool) and removal p...
9
Geochemistry
Facilitating drug absorption by increasing its solubility in water is a common pharmaceutical strategy and also has been shown to be successful for CoQ. Various approaches have been developed to achieve this goal, with many of them producing significantly better results over oil-based softgel capsules in spite of the m...
1
Biochemistry