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A macromonomer is a macromolecule with one end-group that enables it to act as a monomer. Macromonomers will contribute a single monomeric unit to a chain of the completed macromolecule.
Several macromonomers have been successfully synthesized utilizing various methods such as controlled radical polymerization (CRP) and copper-catalyzed "click" coupling.
Due to the larger size of macromonomers (as opposed to the size of regular monomers), synthetic challenges are brought about, giving reason for the analysis of polymerization mechanisms. Recent studies have shown that macromonomer polymerization kinetics and mechanisms can be significantly affected by the topological effect. | 0 | Theoretical and Fundamental Chemistry |
AWWA presents a number of awards every year to individuals who provide notable service to the drinking water community. Among the major awards given are the Abel Wolman Award of Excellence, the George Warren Fuller Award, and the Dr. John L. Leal Award. | 1 | Applied and Interdisciplinary Chemistry |
Because the Zeeman interaction is a function of magnetic field and Larmor frequency, it can be obstructed or amplified by altering the external magnetic or the Larmor frequency with experimental instruments that generate oscillating fields. It has been observed that migratory birds lose their navigational abilities in such conditions where the Zeeman interaction is obstructed in radical-pairs. | 0 | Theoretical and Fundamental Chemistry |
Being a good solvent for many materials (such as grease and tar), carbon tetrachloride was widely used as a cleaning fluid for nearly 70 years. It is nonflammable and nonexplosive and did not leave any odour on the cleaned material, unlike gasoline, which was also used for cleaning at the time. It was used as a "safe" alternative to gasoline. It was first marketed as Katharin, in 1890 or 1892 and as Benzinoform later.
Carbon tetrachloride was the first chlorinated solvent to be used in dry-cleaning and was used until the 1950s. It had the downsides of being corrosive to the dry-cleaning equipment and causing illness among dry-cleaning operators, and was replaced by trichloroethylene, tetrachloroethylene and methyl chloroform (trichloroethane).
Carbon tetrachloride was also used as an alternative to petrol (gasoline) in dry shampoos, from the beginning of 1903 to the 1930s. Several women had fainted from its fumes during the hair wash in barber shops, the hairdressers often used electric fans to blow the fumes away. In 1909, a baronet's daughter, Helenora Elphinstone-Dalrymple (aged 29), died after having her hair shampooed with carbon tetrachloride.
It is assumed that carbon tetrachloride was still used as a dry cleaning solvent in North Korea as of 2006. | 1 | Applied and Interdisciplinary Chemistry |
Capnellene is a naturally occurring tricyclic hydrocarbon derived from Capnella imbricata, a species of soft coral found in Indonesia. Since the 1970s, capnellene has been targeted for synthesis by numerous investigators due to its stereochemistry, functionality, and the interesting geometry of the carbon skeleton. Many alcohol derivatives of capnellene have demonstrated potential as a chemotherapeutic agent with antibacterial, anti-inflammatory and anti-tumor properties. | 0 | Theoretical and Fundamental Chemistry |
Nanochemistry is an emerging sub-discipline of the chemical and material sciences that deals with the development of new methods for creating nanoscale materials. The term "nanochemistry" was first used by Ozin in 1992 as the uses of chemical synthesis to reproducibly afford nanomaterials from the atom "up", contrary to the nanoengineering and nanophysics approach that operates from the bulk "down". Nanochemistry focuses on solid-state chemistry that emphasizes synthesis of building blocks that are dependent on size, surface, shape, and defect properties, rather than the actual production of matter. Atomic and molecular properties mainly deal with the degrees of freedom of atoms in the periodic table. However, nanochemistry introduced other degrees of freedom that controls material's behaviors by transformation into solutions. Nanoscale objects exhibit novel material properties, largely as a consequence of their finite small size. Several chemical modifications on nanometer-scaled structures approve size dependent effects.
Nanochemistry is used in chemical, materials and physical science as well as engineering, biological, and medical applications. Silica, gold, polydimethylsiloxane, cadmium selenide, iron oxide, and carbon are materials that show its transformative power. Nanochemistry can make the most effective contrast agent of MRI out of iron oxide (rust) which can detect cancers and kill them at their initial stages. Silica (glass) can be used to bend or stop lights in their tracks. Developing countries also use silicone to make circuits for the fluids used in pathogen detection. Nano-construct synthesis leads to the self-assembly of the building blocks into functional structures that may be useful for electronic, photonic, medical, or bioanalytical problems. Nanochemical methods can be used to create carbon nanomaterials such as carbon nanotubes, graphene, and fullerenes which have gained attention in recent years due to their remarkable mechanical and electrical properties. | 0 | Theoretical and Fundamental Chemistry |
* Jung, C. G. 1968. Psychology and Alchemy, Collected Works of C. G. Jung. Princeton, NJ: Princeton University Press.
* Jung, C. G. 1980. Psychology and Alchemy (2nd ed.), Collected Works of C. G. Jung. London: Routledge.
* Jung, C. G. 1980, Psychology and Alchemy Arabic version 2023 Translated by Salma Elsharkawy From ElRawy publishing house (Cover art by Mohammed Derbala) | 1 | Applied and Interdisciplinary Chemistry |
Analytical ultracentrifugation is an analytical technique which combines an ultracentrifuge with optical monitoring systems.
In an analytical ultracentrifuge (commonly abbreviated as AUC), a sample’s sedimentation profile is monitored in real time by an optical detection system. The sample is detected via ultraviolet light absorption and/or interference optical refractive index sensitive system, monitored by light-sensitive diode array or by film in the older machines. The operator can thus observe the change of sample concentration versus the axis of the rotation profile with time as a result of the applied centrifugal field. With modern instrumentation, these observations are electronically digitized and stored for further mathematical analysis.
The information that can be obtained from an analytical ultracentrifuge includes the gross shape of macromolecules, conformational changes in macromolecules, and size distributions of macromolecules. With AUC it is possible to gain information on the number and subunit stoichiometry of non-covalent complexes and equilibrium constants of macromolecules such as proteins, DNA, nanoparticles or other assemblies from different molecule classes. The simplest measurement to be obtained is the sedimentation coefficient, which depends upon the size of the molecules being sedimented. This is the ratio of a particle's sedimentation velocity to the applied acceleration causing the sedimentation.
Analytical ultracentrifugation has recently seen a rise in use because of increased ease of analysis with modern computers and the development of software, including a National Institutes of Health supported software package, SedFit. | 1 | Applied and Interdisciplinary Chemistry |
Longifolene is the common (or trivial) chemical name of a naturally occurring, oily liquid hydrocarbon found primarily in the high-boiling fraction of certain pine resins. The name is derived from that of a pine species from which the compound was isolated,
Chemically, longifolene is a tricyclic sesquiterpene. This molecule is chiral, and the enantiomer commonly found in pines and other higher plants exhibits a positive optical rotation of +42.73°. The other enantiomer (optical rotation −42.73°) is found in small amounts in certain fungi and liverworts.
Longifolene is also one of two most abundant aroma constituents of lapsang souchong tea, because the tea is smoked over pinewood fires. | 0 | Theoretical and Fundamental Chemistry |
Hawkins et al.. demonstrated the toxic effects of CYN by mouse bioassay, using an extract of the original Palm Island strain. Acutely poisoned mice displayed anorexia, diarrhoea and gasping respiration. Autopsy results revealed haemorrhages in the lungs, livers, kidneys, small intestines and adrenal glands. Histopathology revealed dose-related necrosis of hepatocytes, lipid accumulation, and fibrin thrombi formation in blood vessels of the liver and lungs, along with varying epithelial cell necrosis in areas of the kidneys.
A more recent mouse bioassay of the effects of cylindrospermopsin revealed an increase in liver weight, with both lethal and non-lethal doses; in addition the livers appeared dark-coloured. Extensive necrosis of hepatocytes was visible in mice administered a lethal dose, and some localised damage was also observed in mice administered a non-lethal dose. | 0 | Theoretical and Fundamental Chemistry |
ELSDs analyze solutes eluting out of the chromatographic column, both in LC and SFC. As the eluent exits the columns outlet into the detector inlet, it is mixed with an inert carrier gas (usually nitrogen) and forced through a nebulizer, which separates the liquid into fine aerosolized droplets. These droplets then pass into a heated drift tube, where the mobile phase solvent is evaporated off. As the mobile phase evaporates, the droplets become smaller and smaller until all that is left is minute particles of dried analyte. These particles are pushed through the drift tube by the carrier gas to the detection region. In this region, a beam of light crosses the column of analyte and the scattering of light is measured by a photodiode or photomultiplier tube. The detectors output is non-linear across more than one order of magnitude and proper calibration is required for quantitative analysis. | 0 | Theoretical and Fundamental Chemistry |
Ab initio quantum mechanical methods simulate liquids using only the laws of quantum mechanics and fundamental atomic constants. In contrast with classical molecular dynamics, the intermolecular force fields are an output of the calculation, rather than an input based on experimental measurements or other considerations. In principle, ab initio methods can simulate the properties of a given liquid without any prior experimental data. However, they are very expensive computationally, especially for large molecules with internal structure. | 0 | Theoretical and Fundamental Chemistry |
Metabolism is also dependent on the species of organism; different organisms have slightly different P450 enzymes that metabolize certain PCBs better than others. Looking at the PCB metabolism in the liver of four sea turtle species (green, olive ridley, loggerhead and hawksbill), green and hawksbill sea turtles have noticeably higher hydroxylation rates of PCB 52 than olive ridley or loggerhead sea turtles. This is because the green and hawksbill sea turtles have higher P450 2-like protein expression. This protein adds three hydroxyl groups to PCB 52, making it more polar and water-soluble. P450 3-like protein expression that is thought to be linked to PCB 77 metabolism, something that was not measured in this study. | 1 | Applied and Interdisciplinary Chemistry |
Shq1p is a protein involved in the rRNA processing pathway. It was discovered by Pok Yang in the Chanfreau laboratory at UCLA. Depletion of Shq1p has led to decreased level of various H/ACA box snoRNAs (H/ACA box snoRNAs are responsible for pseuduridylation of pre-rRNA) and certain pre-rRNA intermediates. | 1 | Applied and Interdisciplinary Chemistry |
Trains and trams stay on their tracks primarily due to the conical geometry of their wheels. They also have a flange on one side to keep the wheels, and hence the train, running on the rails, when the limits of the geometry-based alignment are reached, either due to some emergency or defect, or simply because the curve radius is so low that self-steering normally provided by the coned wheel tread is no longer effective. | 1 | Applied and Interdisciplinary Chemistry |
Davies Giddy met Davy in Penzance carelessly swinging on the half-gate of Dr Borlases house, and interested by his talk invited him to his house at Tredrea and offered him the use of his library. This led to his introduction to Dr Edwards, who lived at Hayle Copper House. Edwards was a lecturer in chemistry in the school of St. Bartholomews Hospital. He permitted Davy to use his laboratory and possibly directed his attention to the floodgates of the port of Hayle, which were rapidly decaying as a result of the contact between copper and iron under the influence of seawater. Galvanic corrosion was not understood at that time, but the phenomenon prepared Davys mind for subsequent experiments on ships copper sheathing. Gregory Watt, son of James Watt, visited Penzance for his healths sake, and while lodging at the Davys house became a friend and gave him instructions in chemistry. Davy was acquainted with the Wedgwood family, who spent a winter at Penzance. | 1 | Applied and Interdisciplinary Chemistry |
An early ironmaster was John Winter (about 1600–1676) who owned substantial holdings in the Forest of Dean. During the English Civil War he cast cannons for Charles I. Following the Restoration, Winter developed his interest in the iron industry, and experimented with a new type of coking oven. This was a precursor to the later work of Abraham Darby I who successfully used coke to smelt iron. | 1 | Applied and Interdisciplinary Chemistry |
The asteranes contain a methylene group bridge on each edge between the two n-gon bases. Each side is thus a cyclohexane rather than a cyclobutane. | 0 | Theoretical and Fundamental Chemistry |
In fluid dynamics Jeffery–Hamel flow is a flow created by a converging or diverging channel with a source or sink of fluid volume at the point of intersection of the two plane walls. It is named after George Barker Jeffery(1915) and Georg Hamel(1917), but it has subsequently been studied by many major scientists such as von Kármán and Levi-Civita, Walter Tollmien, F. Noether, W.R. Dean, Rosenhead, Landau, G.K. Batchelor etc. A complete set of solutions was described by Edward Fraenkel in 1962. | 1 | Applied and Interdisciplinary Chemistry |
With a narrower, direct band gap (2.4 eV) and proper band alignment with water oxidation potential, the monoclinic form of Bismuth vanadate| has garnered interest from researchers. Over time, it has been shown that V-rich and compact films are associated with higher photocurrent, or higher performance. Bismuth Vanadate has also been studied for solar generation from seawater, which is much more difficult due to the presence of contaminating ions and a more harsh corrosive environment. | 0 | Theoretical and Fundamental Chemistry |
The primary functions of metallic foams in vehicles are to increase sound damping, reduce weight, increase energy absorption in case of crashes, and (in military applications) to combat the concussive force of IEDs. As an example, foam filled tubes could be used as anti-intrusion bars. Because of their low density (0.4–0.9 g/cm), aluminium and aluminium alloy foams are under particular consideration. These foams are stiff, fire resistant, nontoxic, recyclable, energy absorbent, less thermally conductive, less magnetically permeable, and more efficiently sound dampening, especially when compared to hollow parts. Metallic foams in hollow car parts decrease weakness points usually associated with car crashes and vibration. These foams are inexpensive to cast with powder metallurgy, compared to casting other hollow parts.
Compared to polymer foams in vehicles, metallic foams are stiffer, stronger, more energy absorbent, and resistant to fire and the weather adversities of UV light, humidity, and temperature variation. However, they are heavier, more expensive, and non-insulating.
Metal foam technology has been applied to automotive exhaust gas. Compared to traditional catalytic converters that use cordierite ceramic as substrate, metal foam substrate offers better heat transfer and exhibits excellent mass-transport properties (high turbulence) and may reduce the quantity of platinum catalyst required. | 0 | Theoretical and Fundamental Chemistry |
Methyl orange is a pH indicator frequently used in titration because of its clear and distinct color variance at different pH values. Methyl orange shows red color in acidic medium and yellow color in basic medium. Because it changes color at the pK of a mid strength acid, it is usually used in titration of strong acids in weak bases that reach the equivalence point at a pH of 3.1-4.4. Unlike a universal indicator, methyl orange does not have a full spectrum of color change, but it has a sharp end point. In a solution becoming less acidic, methyl orange changes from red to orange and, finally, to yellow—with the reverse process occurring in a solution of increasing acidity. | 0 | Theoretical and Fundamental Chemistry |
The Society's annual meeting is held at the same time and place as the annual meeting of the American Institute of Chemical Engineers.
Governance is vested in a national president, vice president, executive secretary, and treasurer. With the immediate past president, these constitute the Executive Committee. The current national president is Dr. Christi Luks of the Missouri University of Science and Technology. | 1 | Applied and Interdisciplinary Chemistry |
In mineralogy, epitaxy is the overgrowth of one mineral on another in an orderly way, such that certain crystal directions of the two minerals are aligned. This occurs when some planes in the lattices of the overgrowth and the substrate have similar spacings between atoms.
If the crystals of both minerals are well formed so that the directions of the crystallographic axes are clear then the epitaxic relationship can be deduced just by a visual inspection.
Sometimes many separate crystals form the overgrowth on a single substrate, and then if there is epitaxy all the overgrowth crystals will have a similar orientation. The reverse, however, is not necessarily true. If the overgrowth crystals have a similar orientation there is probably an epitaxic relationship, but it is not certain.
Some authors consider that overgrowths of a second generation of the same mineral species should also be considered as epitaxy, and this is common terminology for semiconductor scientists who induce epitaxic growth of a film with a different doping level on a semiconductor substrate of the same material. For naturally produced minerals, however, the International Mineralogical Association (IMA) definition requires that the two minerals be of different species.
Another man-made application of epitaxy is the making of artificial snow using silver iodide, which is possible because hexagonal silver iodide and ice have similar cell dimensions. | 0 | Theoretical and Fundamental Chemistry |
In her fifth paper on cyclols (1937), Wrinch identified the conditions under which two planar cyclol fabrics could be joined to make an angle between their planes while respecting the chemical bond angles. She identified a mathematical simplification, in which the non-planar six-membered rings of atoms can be represented by planar "median hexagon"s made from the midpoints of the chemical bonds. This "median hexagon" representation made it easy to see that the cyclol fabric planes can be joined correctly if the dihedral angle between the planes equals the tetrahedral bond angle δ = arccos(-1/3) ≈ 109.47°.
A large variety of closed polyhedra meeting this criterion can be constructed, of which the simplest are the truncated tetrahedron, the truncated octahedron, and the octahedron, which are Platonic solids or semiregular polyhedra. Considering the first series of "closed cyclols" (those modeled on the truncated tetrahedron), Wrinch showed that their number of amino acids increased quadratically as 72n, where n is the index of the closed cyclol C. Thus, the C cyclol has 72 residues, the C cyclol has 288 residues, etc. Preliminary experimental support for this prediction came from Max Bergmann and Carl Niemann, whose amino-acid analyses suggested that proteins were composed of integer multiples of 288 amino-acid residues (n=2). More generally, the cyclol model of globular proteins accounted for the early analytical ultracentrifugation results of Theodor Svedberg, which suggested that the molecular weights of proteins fell into a few classes related by integers.
The cyclol model was consistent with the general properties then attributed to folded proteins. (1) Centrifugation studies had shown that folded proteins were significantly denser than water (~1.4 g/mL) and, thus, tightly packed; Wrinch assumed that dense packing should imply regular packing. (2) Despite their large size, some proteins crystallize readily into symmetric crystals, consistent with the idea of symmetric faces that match up upon association. (3) Proteins bind metal ions; since metal-binding sites must have specific bond geometries (e.g., octahedral), it was plausible to assume that the entire protein also had similarly crystalline geometry. (4) As described above, the cyclol model provided a simple chemical explanation of denaturation and the difficulty of cleaving folded proteins with proteases. (5) Proteins were assumed to be responsible for the synthesis of all biological molecules, including other proteins. Wrinch noted that a fixed, uniform structure would be useful for proteins in templating their own synthesis, analogous to the Watson-Francis Crick concept of DNA templating its own replication. Given that many biological molecules such as sugars and sterols have a hexagonal structure, it was plausible to assume that their synthesizing proteins likewise had a hexagonal structure. Wrinch summarized her model and the supporting molecular-weight experimental data in three review articles. | 1 | Applied and Interdisciplinary Chemistry |
Tebbe's reagent itself does not react with carbonyl compounds, but must first be treated with a mild Lewis base, such as pyridine, which generates the active Schrock carbene.
Also analogous to the Wittig reagent, the reactivity appears to be driven by the high oxophilicity of Ti(IV). The Schrock carbene (1) reacts with carbonyl compounds (2) to give a postulated oxatitanacyclobutane intermediate (3). This cyclic intermediate has never been directly isolated, presumably because it breaks down immediately to the produce the desired alkene (5). | 0 | Theoretical and Fundamental Chemistry |
Most cases of bacterial gastroenteritis are caused by food-borne enteric microorganisms, such as Salmonella and Campylobacter; however, it is also important to understand the risk of exposure to pathogens via recreational waters. This is especially the case in watersheds where human or animal wastes are discharged to streams and downstream waters are used for swimming or other recreational activities. Other important pathogens other than bacteria include viruses such as rotavirus, hepatitis A and hepatitis E and protozoa like giardia, cryptosporidium and Naegleria fowleri. Due to the difficulties associated with monitoring pathogens in the environment, risk assessments often rely on the use of indicator bacteria. | 0 | Theoretical and Fundamental Chemistry |
The definition of ecosan has varied in the past. In 2012, a widely accepted definition of ecosan was formulated by Swedish experts: "Ecological sanitation systems are systems which allow for the safe recycling of nutrients to crop production in such a way that the use of non-renewable resources is minimized. These systems have a strong potential to be sustainable sanitation systems if technical, institutional, social and economic aspects are managed appropriately."
Prior to 2012, ecosan has often been associated with urine diversion and in particular with urine-diverting dry toilets (UDDTs), a type of dry toilet. For this reason, the term "ecosan toilet" is widely used when people mean a UDDT. However, the ecosan concept should not be limited to one particular type of toilet. Also, UDDTs can be used without having any reuse activities in which case they are not in line with the ecosan concept (an example being the 80,000 UDDTs implemented by eThekwini Municipality near Durban, South Africa). | 1 | Applied and Interdisciplinary Chemistry |
Concentrated sulfuric acid has a powerful dehydrating property, removing water () from other chemical compounds such as table sugar (sucrose) and other carbohydrates, to produce carbon, steam, and heat. Dehydration of table sugar (sucrose) is a common laboratory demonstration. The sugar darkens as carbon is formed, and a rigid column of black, porous carbon called a carbon snake may emerge as shown in the figure.
Similarly, mixing starch into concentrated sulfuric acid gives elemental carbon and water. The effect of this can be seen when concentrated sulfuric acid is spilled on paper, which is composed of cellulose; the cellulose reacts to give a burnt appearance in which the carbon appears much like soot that results from fire.
Although less dramatic, the action of the acid on cotton, even in diluted form, destroys the fabric.
The reaction with copper(II) sulfate can also demonstrate the dehydration property of sulfuric acid. The blue crystals change into white powder as water is removed: | 0 | Theoretical and Fundamental Chemistry |
One group of researchers applied the field of neuroproteomics to examine how different proteins affect the initial growth of neuritis. The experiment compared the protein activity of control neurons with the activity of neurons treated with nerve growth factor (NGF) and JNJ460, an “immunophilin ligand.” JNJ460 is an offspring of another drug that is used to prevent immune attack when organs are transplanted. It is not an immunosuppressant, however, but rather it acts as a shield against microglia. NGF promotes neuron viability and differentiation by binding to TrkA, a tyrosine receptor kinase. This receptor is important in initiating intracellular metabolic pathways, including Ras, Rak, and MAP kinase.
Protein differentiation was measured in each cell sample with and without treatment by NGF and JNJ460. A peptide mixture was made by washing off unbound portions of the amino acid sequence in a reverse column. The resulting mixture was then suspended a peptide mixture in a bath of cation exchange fluid. The proteins were identified by splicing them with trypsin and then searching through the results of passing the product through a mass spectrometer. This applies a form of liquid chromatography mass spectrometry to identify proteins in the mixture
JNJ460 treatment resulted in an increase in “signal transduction” proteins, while NGF resulted in an increase in proteins associated with the ribosome and synthesis of other proteins. JNJ460 also resulted in more structural proteins associated with intercellular growth, such as actin, myosin, and troponin. With NGF treatment, cells increased protein synthesis and creation of ribosomes. This method allows the analysis of all of the protein patterns overall, rather than a single change in an amino acid. Western blots confirmed the results, according to the researchers, though the changes in proteins were not as obvious in their protocol.
The main significance to these findings are that JNJ460 are NGF are distinct processes that both control the protein output of the cell. JNJ460 resulted in increased neuronal size and stability while NGF resulted in increased membrane proteins. When combined, they significantly increase a neuron’s chance of growth. While JNJ460 may “prime” some parts of the cell for NGF treatment, they do not work together. JNJ460 is thought to interact with Schwann cells in regenerating actin and myosin, which are key players in axonal growth. NGF helps the neuron grow as a whole. These two proteins do not play a part in communication with other neurons, however. They merely increase the size of the membrane down which a signal can be sent. Other neurotrophic factor proteomes are needed to guide neurons to each other to create synapses. | 1 | Applied and Interdisciplinary Chemistry |
Triple-point cells are used in the calibration of thermometers. For exacting work, triple-point cells are typically filled with a highly pure chemical substance such as hydrogen, argon, mercury, or water (depending on the desired temperature). The purity of these substances can be such that only one part in a million is a contaminant, called "six nines" because it is 99.9999% pure. A specific isotopic composition (for water, VSMOW) is used because variations in isotopic composition cause small changes in the triple point. Triple-point cells are so effective at achieving highly precise, reproducible temperatures, that an international calibration standard for thermometers called ITS–90 relies upon triple-point cells of hydrogen, neon, oxygen, argon, mercury, and water for delineating six of its defined temperature points. | 0 | Theoretical and Fundamental Chemistry |
The potentially unlimited source of cell and tissues may have direct application for tissue engineering, cell replacement and transplantation following acute injuries and reconstructive surgery. These applications are limited to the cell types that can be differentiated efficiently and safely from human PSCs with the proper organogenesis. Decellularized organs are also being used as tissue scaffold for organogenesis. Source material can be normal healthy cells from another donor (heterologous transplantation) or genetically corrected from the same patient (autologous).
Concerns on patient safety have been raised due to the possibility of contaminating undifferentiated cells. The first clinical trial using hESC-derived cells was in 2011. The first clinical trial using hiPSC-derived cells started in 2014 in Japan. | 1 | Applied and Interdisciplinary Chemistry |
Alpha- beta- and gamma rays can only be emitted if the conservation laws (energy, angular momentum, parity) are obeyed. This leads to so-called selection rules.
Applications for gamma decay can be found in Multipolarity of gamma radiation. To discuss such a rule in a particular case, it is necessary to know angular momentum and parity for every state. The figure shows the Co decay scheme again, with spins and parities given for every state. | 0 | Theoretical and Fundamental Chemistry |
The CH vertices of closo-dicarbadodecaboranes undergo deprotonation upon treatment with organolithium reagents:
: CBH + 2 BuLi → LiCBH + 2 BuH
These dilithiated compounds react with a variety of electrophiles, e.g. chlorophosphines, chlorosilanes, and sulfur. Many of the same compounds can be produced by hydroboration of alkynes:
:LiCBH + 2 RX → RCBH + 2LiX
:LBH + RCR → RCBH + 2L (L = MeCN, etc.)
ortho-Carborane can be converted to highly reactive carborynes with the formula BCH. | 0 | Theoretical and Fundamental Chemistry |
Hybrid nuclear fusion–fission (hybrid nuclear power) is a proposed means of generating power by use of a combination of nuclear fusion and fission processes.
The basic idea is to use high-energy fast neutrons from a fusion reactor to trigger fission in non-fissile fuels like U-238 or Th-232. Each neutron can trigger several fission events, multiplying the energy released by each fusion reaction hundreds of times. As the fission fuel is not fissile, there is no self-sustaining chain reaction from fission. This would not only make fusion designs more economical in power terms, but also be able to burn fuels that were not suitable for use in conventional fission plants, even their nuclear waste.
In general terms, the hybrid is similar in concept to the fast breeder reactor, which uses a compact high-energy fission core in place of the hybrid's fusion core. Another similar concept is the accelerator-driven subcritical reactor, which uses a particle accelerator to provide the neutrons instead of nuclear reactions. | 0 | Theoretical and Fundamental Chemistry |
AGEs have a range of pathological effects, such as:
* Increased vascular permeability.
* Increased arterial stiffness
* Inhibition of vascular dilation by interfering with nitric oxide.
* Oxidizing LDL.
* Binding cells—including macrophage, endothelial, and mesangial—to induce the secretion of a variety of cytokines.
* Enhanced oxidative stress.
* Hemoglobin-AGE levels are elevated in diabetic individuals and other AGE proteins have been shown in experimental models to accumulate with time, increasing from 5-50 fold over periods of 5–20 weeks in the retina, lens and renal cortex of diabetic rats. The inhibition of AGE formation reduced the extent of nephropathy in diabetic rats. Therefore, substances that inhibit AGE formation may limit the progression of disease and may offer new tools for therapeutic interventions in the therapy of AGE-mediated disease.
* AGEs have specific cellular receptors; the best-characterized are those called RAGE. The activation of cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggers the generation of free radicals and the expression of inflammatory gene mediators. Such increases in oxidative stress lead to the activation of the transcription factor NF-κB and promote the expression of NF-κB regulated genes that have been associated with atherosclerosis. | 1 | Applied and Interdisciplinary Chemistry |
In photochemistry, photohydrogen is hydrogen produced with the help of artificial or natural light. This is how the leaf of a tree splits water molecules into protons (hydrogen ions), electrons (to make carbohydrates) and oxygen (released into the air as a waste product). Photohydrogen may also be produced by the photodissociation of water by ultraviolet light.
Photohydrogen is sometimes discussed in the context of obtaining renewable energy from sunlight, by using microscopic organisms such as bacteria or algae. These organisms create hydrogen with the help of hydrogenase enzymes which convert protons derived from the water splitting reaction into hydrogen gas which can then be collected and used as a biofuel. | 0 | Theoretical and Fundamental Chemistry |
Genomic information from surrounding genomic elements is among the most useful information for interpreting the biological function of an observed variant. Information from a known gene is used as a reference to indicate whether the observed variant resides in or near a gene and if it has the potential to disrupt the protein sequence and its function. Gene based annotation is based on the fact that non-synonymous mutations can alter the protein sequence and that splice site mutation may disrupt the transcript splicing pattern. | 1 | Applied and Interdisciplinary Chemistry |
Radiogenic isotopes provide powerful tracers for studying the ages and origins of Earth systems. They are particularly useful to understand mixing processes between different components, because (heavy) radiogenic isotope ratios are not usually fractionated by chemical processes.
Radiogenic isotope tracers are most powerful when used together with other tracers: The more tracers used, the more control on mixing processes. An example of this application is to the evolution of the Earths crust and Earths mantle through geological time. | 0 | Theoretical and Fundamental Chemistry |
The standard fiber optical trap relies on the same principle as the optical trapping, but with the Gaussian laser beam delivered through an optical fiber. If one end of the optical fiber is molded into a lens-like facet, the nearly gaussian beam carried by a single mode standard fiber will be focused at some distance from the fiber tip. The effective Numerical Aperture of such assembly is usually not enough to allow for a full 3D optical trap but only for a 2D trap (optical trapping and manipulation of objects will be possible only when, e.g., they are in contact with a surface ).
A true 3D optical trapping based on a single fiber, with a trapping point which is not in nearly contact with the fiber tip, has been realized based on a not-standard annular-core fiber arrangement and a total-internal-reflection geometry.
On the other hand, if the ends of the fiber are not moulded, the laser exiting the fiber will be diverging and thus a stable optical trap can only be realised by balancing the gradient and the scattering force from two opposing ends of the fiber. The gradient force will trap the particles in the transverse direction, while the axial optical force comes from the scattering force of the two counter propagating beams emerging from the two fibers. The equilibrium z-position of such a trapped bead is where the two scattering forces equal each other. This work was pioneered by A. Constable et al., Opt. Lett. 18,1867 (1993), and followed by J.Guck et al., Phys. Rev. Lett. 84, 5451 (2000), who made use of this technique to stretch microparticles. By manipulating the input power into the two ends of the fiber, there will be an increase of an "optical stretching" that can be used to measure viscoelastic properties of cells, with sensitivity sufficient to distinguish between different individual cytoskeletal phenotypes. i.e. human erythrocytes and mouse fibroblasts. A recent test has seen great success in differentiating cancerous cells from non-cancerous ones from the two opposed, non-focused laser beams. | 1 | Applied and Interdisciplinary Chemistry |
Transcription activator-like effector nucleases (TALEN) are restriction enzymes that can be engineered to cut specific sequences of DNA. They are made by fusing a TAL effector DNA-binding domain to a DNA cleavage domain (a nuclease which cuts DNA strands). Transcription activator-like effectors (TALEs) can be engineered to bind to practically any desired DNA sequence, so when combined with a nuclease, DNA can be cut at specific locations. The restriction enzymes can be introduced into cells, for use in gene editing or for genome editing in situ, a technique known as genome editing with engineered nucleases. Alongside zinc finger nucleases and CRISPR/Cas9, TALEN is a prominent tool in the field of genome editing. | 1 | Applied and Interdisciplinary Chemistry |
Dye runs a Youtube channel, personal blog, and has courses on Coursera to teach metallurgy, mathematics and data analysis, continuum mechanics, and engineering Alloys. Dye also is a scientific witness to the Science and Technology Committee of the UK parliament. | 1 | Applied and Interdisciplinary Chemistry |
Piperacillin is generally available in their stable form as crystallized potassium or sodium salt, quickly losing bactericidal activity upon dissolution due to their short half-lives. As the gastrointestinal tract does not absorb piperacillin and tazobactam, they are dissolved in a solution before being administered to a patient, through parenteral means. Excreted through renal mechanisms like glomerular or tubular filtration as a component of urine, uncontrolled dosages of the drug can cause renal dysfunction and competitive inhibition of excretion, delaying piperacillin-tazobactam excretion, and endangering patients to drug exposure.
Although the distribution of the drug remained the same, the half-life for elimination increased by three to five folds for patients diagnosed with renal dysfunction. Measured by creatinine clearance (CrCl), patients with less than 30 mL/min of clearance had significantly reduced levels of piperacillin/tazobactam excretion, measuring down to 35% of the initial dosage, while the area under the curve (AUC) for piperacillin increased by about three folds for those with less than 20 mL/min. A reduced dosage or alteration in the interval of administration is recommended for patients lying under 40 mL/min of CrCl, depending on the severity of dysfunction.
Renal is the main pathway for drug elimination for both tazobactam and piperacillin in the body. While there are other non-renal means of drug elimination like hepatobiliary excretion, they occur less frequently. A substantial amount (~80%) of piperacillin found in urine when excreted through glomerular and tubular filtration is unmetabolized. Tazobactam renal elimination may be significantly reduced through piperacillin interaction, dropping from 63.7% to 56.8% of the administered dose over a 24-hour period. Piperacillin may be actively diffused through filtration into the biliary tract during renal clearing, indicated by a generally higher concentration of piperacillin than tazobactam in the bile. The metabolites that make up the remaining percentage in the excreted urine are composed of M1 (inactive) and N-desethyl-piperacillin (active), formed from the division of β-lactam rings of both tazobactam and piperacillin respectively.
Due to the hydrophilic nature of piperacillin-tazobactam, a volume distribution of ~15 L amounting to various sites (tissues) is desired, as hydrophilic compounds are not able to pass through plasma membranes as easily as hydrophobic compounds. Concentrations often in the range of 90 MIC or above are located in specific areas including the gallbladder, lung, muscle, and skin, making up 16–85% of the plasma concentrations. The concentration of piperacillin-tazobactam is especially lower in fatty tissue, making up less than 10% of the plasma concentrations. | 0 | Theoretical and Fundamental Chemistry |
It is uncommon, but possible for NBS to oxidize alcohols. E. J. Corey et al. found that one can selectively oxidize secondary alcohols in the presence of primary alcohols using NBS in aqueous dimethoxyethane (DME). | 0 | Theoretical and Fundamental Chemistry |
ThYme (Thioester-active enzYme) is database of enzymes constituting the fatty acid synthesis and polyketide synthesis cycles. | 1 | Applied and Interdisciplinary Chemistry |
Bivalirudin, a 20 amino acid polypeptide, is a synthetic analog of hirudin. Like the hirudins it is also a bivalent DTI. It has an amino-terminal D-Phe-Pro-Arg-Pro domain that is linked via four Gly residues to a dodecapeptide analog of the carboxy-terminal of hirudin. The amino-terminal domain binds to the active site and the carboxy-terminal domain binds to exosite 1 on thrombin. Different from the hirudins, once bound thrombin cleaves the Arg-Pro bond at the amino-terminal of bivalirudin and as a result restores the functions to the active site of the enzyme. Even though the carboxy-terminal domain of bivalirudin is still bound to exosite 1 on thrombin, the affinity of the bond is decreased after the amino-terminal is released. This allows substrates to substrates to compete with cleaved bivalirudin for access to exosite 1 on thrombin. The use of bivalirudin has mostly been studied in the setting of acute coronary syndrome. A few studies indicate that bivalirudin is non-inferior compared to heparin and that bivalirudin is associated with a lower rate of bleeding. Unlike the hirudins, bivalirudin is only partially (about 20%) excreted by the kidneys, other sites such as hepatic metabolism and proteolysis also contribute to its metabolism, making it safer to use in patients with renal impairment; however, dose adjustments are needed in severe renal impairment. | 1 | Applied and Interdisciplinary Chemistry |
Dalton Discussions are scientific meetings that provide a forum for the exchange of views and newly acquired results in focused areas of inorganic chemistry. The papers, which are associated with the oral presentations at the meeting, are published in a special issue of the journal, which constitutes a permanent record of the meeting. The meetings are usually held annually. | 0 | Theoretical and Fundamental Chemistry |
Clarke was elected to the National Academy of Sciences in 1942, and served on the boards of the Journal of the American Chemical Society and of the Journal of Biological Chemistry. He was a member of the American Philosophical Society, the American Chemical Society, the American Otological Society, and the American Society of Biological Chemists. He is probably best known for his work on the eponymously named Eschweiler-Clarke reaction. In 1973 his widow donated his voluminous personal and research papers to the American Philosophical Society.
Clarke was named Assistant Director of the Office of Scientific Research and Development in 1944, which placed him in charge of coordinating penicillin production in the United States.
Clarke served as Science attaché to the US Embassy in London (1951–52). He was able to work closely with Sir Robert Robinson, with whom he had edited a major book on research in penicillin (issued in 1949).
Clarke was chairman of the Rochester section of the American Chemical Society (1921), of the New York section (1946) and of the Organic Chemistry Division (1924–25). He worked on the Committee on Professional Training, and the Garvin Award Committee. He was a president of the American Society of Biological Chemists (1947). He served on several grant-allocating committees. As a member of the Otological Society he served on a grants committee from 1956 to 1962. He was Chairman of the Merck Fellowship Board of the National Academy of Sciences in 1957.
Clarke was much in demand for his talents as a lucid writer and was called on to serve as editor or referee throughout his career. He sat on the editorial board of Organic Syntheses (1921–32), and on the editorial board of the Journal of Biological Chemistry (1937–51), and was associate editor of the Journal of the American Chemical Society (1928–38)
Clarke was an expert clarinet player, and received numerous requests to perform. His donated papers include one notebook dedicated to clarinet performance. | 0 | Theoretical and Fundamental Chemistry |
A transcriptome in vivo analysis tag (TIVA tag) is a multifunctional, photoactivatable mRNA-capture molecule designed for isolating mRNA from a single cell in complex tissues.
__TOC__ | 1 | Applied and Interdisciplinary Chemistry |
One of the issues faced by drug delivery is the solubility of the drug in the body; around
40% of newly detected chemicals found in drug discovery are poorly soluble in water. This low solubility affects the bioavailability of the drug, meaning the rate at which the drug reaches the circulatory system and thus the target site. Low bioavailability is most commonly seen in oral administration, which is the preferred choice for drug administration due to its convenience, low costs, and good patient practice. A measure to improve poor bioavailability is to inject the drugs in a solvent mixture with a solubilizing agent. However, results show this solution is ineffective, with the solubilizing agent demonstrating side-effects and/or toxicity.
Nanocrystals used for drug delivery can increase saturation solubility and dispersion velocity. Generally, saturation solubility is thought to be a function of temperature, but it is also based on other factors, such as crystalline structure and particle size, in regards to nanocrystals. The Ostwald-Freundlich equation below shows this relationship:
Where C is the saturation solubility of the nanocrystal, C is the solubility of the drug at a non-nano scale, σ is the interfacial tension of the substance, V is the molar volume of the particle, R is the gas constant, T is the absolute temperature, 𝜌 is the density of the solid, and r is the radius. The advantage of nanocrystals is that they can improve oral adsorption, bioavailability, action onset and reduces intersubject variability.
Consequently, nanocrystals are now being produced and are on the market for a variety of purposes ranging from antidepressants to appetite stimulants. Nanocrystals can be produced using two different ways: the top-down method or the bottom-up method. Bottom-up technologies are also known as nanoprecipitation. This technique involves dissolving a drug in a suitable solvent and then precipitating it with a non-solvent. On the other hand, top-down technologies use force to reduce the size of a particle to nanometers, usually done by milling a drug. Top-down methods are preferred when working with poorly soluble drugs. | 0 | Theoretical and Fundamental Chemistry |
Several monoclonal antibodies, such as bevacizumab and cetuximab, can cause different kinds of side effects. These side effects can be categorized into common and serious side effects.
Some common side effects include:
* Dizziness
* Headaches
* Allergies
* Diarrhea
* Cough
* Fever
* Itching
* Back pain
* General weakness
* Loss of appetite
* Insomnia
* Constipation
Among the possible serious side effects are:
* Anaphylaxis
* Bleeding
* Arterial and venous blood clots
* Autoimmune thyroiditis
* Hypothyroidism
* Hepatitis
* Heart failure
* Cancer
* Anemia
* Decrease in white blood cells
* Stomatitis
* Enterocolitis
* Gastrointestinal perforation
* Mucositis | 1 | Applied and Interdisciplinary Chemistry |
Murexide (NHCHNO, or CHNO·NH), also called ammonium purpurate or MX, is the ammonium salt of purpuric acid. It is a purple solid that is soluble in water. The compound was once used as an indicator reagent. Aqueous solutions are yellow at low pH, reddish-purple in weakly acidic solutions, and blue-purple in alkaline solutions. | 0 | Theoretical and Fundamental Chemistry |
In gene-activated matrix technology (GAM), cytokines and growth factors could be delivered not as recombinant proteins but as plasmid genes. GAM is one of the tissue engineering approaches to wound healing. Following gene delivery, the recombinant cytokine could be expressed in situ by endogenous would healing cells – in small amounts but for a prolonged period of time – leading to reproducible tissue regeneration. The matrix can be modified by incorporating a viral vector, mRNA or DNA bound to a delivery system, or a naked plasmid. | 1 | Applied and Interdisciplinary Chemistry |
Small nuclear RNA (snRNA) and small nucleolar RNA (snoRNA) are widely known to guide the nucleotide modifications and processing of rRNA. Both snRNA and snoRNA are categorized into a class of small RNA molecules that are present in the nucleus. However, they vary a lot by function. snRNA are 80-350nucletides long while snoRNA are 80-1000 nucleotides long in yeast. snRNA plays a critical role in regulating the pre-mRNA silencing. On the other hand, snoRNAs are involved in mRNA editing, modification of the rRNA and tRNA, and genome imprinting. Major function of snoRNA includes the maturation of rRNA during ribosomal formation. Small nuclear and small nucleolar RNAs are critical components of snRNPs and snoRNPs and play an essential role in the maturation of, respectively, mRNAs and rRNAs within the nucleus of eukaryotic cells. Both snRNA and snoRNA are involved in modifying RNA just after transcription. snRNA can be found in splicing speckles and Cajal bodies of the nucleus of the cell.snRNA and snoRNA requires a phosphorylated adaptor for nuclear export (PHAX) to get transported to the site of action within the nucleus. | 1 | Applied and Interdisciplinary Chemistry |
Paul S. Cremer (born 1967) is an American chemist in physical and analytical chemistry at biological interfaces. | 0 | Theoretical and Fundamental Chemistry |
The V. M. Goldschmidt Award is an award given by the Geochemical Society at the V. M. Goldschmidt Conference for achievements in the fields of geochemistry and cosmochemistry. The award in honor of Victor Moritz Goldschmidt, a pioneer in both those fields. | 0 | Theoretical and Fundamental Chemistry |
The inner mitochondrial membrane contains proteins with three types of functions:
# Those that perform the electron transport chain redox reactions
# ATP synthase, which generates ATP in the matrix
# Specific transport proteins that regulate metabolite passage into and out of the mitochondrial matrix
It contains more than 151 different polypeptides, and has a very high protein-to-phospholipid ratio (more than 3:1 by weight, which is about 1 protein for 15 phospholipids). The inner membrane is home to around 1/5 of the total protein in a mitochondrion. Additionally, the inner membrane is rich in an unusual phospholipid, cardiolipin. This phospholipid was originally discovered in cow hearts in 1942, and is usually characteristic of mitochondrial and bacterial plasma membranes. Cardiolipin contains four fatty acids rather than two, and may help to make the inner membrane impermeable, and its disruption can lead to multiple clinical disorders including neurological disorders and cancer. Unlike the outer membrane, the inner membrane does not contain porins, and is highly impermeable to all molecules. Almost all ions and molecules require special membrane transporters to enter or exit the matrix. Proteins are ferried into the matrix via the translocase of the inner membrane (TIM) complex or via OXA1L. In addition, there is a membrane potential across the inner membrane, formed by the action of the enzymes of the electron transport chain. Inner membrane fusion is mediated by the inner membrane protein OPA1. | 1 | Applied and Interdisciplinary Chemistry |
When sucrose is cooled slowly it results in crystal sugar (or rock candy), but when cooled rapidly it can form syrupy cotton candy (candyfloss).
Vitrification can also occur in a liquid such as water, usually through very rapid cooling or the introduction of agents that suppress the formation of ice crystals. This is in contrast to ordinary freezing which results in ice crystal formation. Vitrification is used in cryo-electron microscopy to cool samples so quickly that they can be imaged with an electron microscope without damage. In 2017, the Nobel prize for chemistry was awarded for the development of this technology, which can be used to image objects such as proteins or virus particles.
Ordinary soda-lime glass, used in windows and drinking containers, is created by the addition of sodium carbonate and lime (calcium oxide) to silicon dioxide. Without these additives, silicon dioxide would require very high temperature to obtain a melt, and subsequently (with slow cooling) a glass.
Vitrification is used in disposal and long-term storage of nuclear waste or other hazardous wastes in a method called geomelting. Waste is mixed with glass-forming chemicals in a furnace to form molten glass that then solidifies in canisters, thereby immobilizing the waste. The final waste form resembles obsidian and is a non-leaching, durable material that effectively traps the waste inside. It is widely assumed that such waste can be stored for relatively long periods in this form without concern for air or groundwater contamination. Bulk vitrification uses electrodes to melt soil and wastes where they lie buried. The hardened waste may then be disinterred with less danger of widespread contamination. According to the Pacific Northwest National Labs, "Vitrification locks dangerous materials into a stable glass form that will last for thousands of years." | 1 | Applied and Interdisciplinary Chemistry |
Sometimes a distinction is made between sequence coverage and physical coverage. Where sequence coverage is the average number of times a base is read, physical coverage is the average number of times a base is read or spanned by mate paired reads. | 1 | Applied and Interdisciplinary Chemistry |
A photopolymer or light-activated resin is a polymer that changes its properties when exposed to light, often in the ultraviolet or visible region of the electromagnetic spectrum. These changes are often manifested structurally, for example hardening of the material occurs as a result of cross-linking when exposed to light. An example is shown below depicting a mixture of monomers, oligomers, and photoinitiators that conform into a hardened polymeric material through a process called curing.
A wide variety of technologically useful applications rely on photopolymers; for example, some enamels and varnishes depend on photopolymer formulation for proper hardening upon exposure to light. In some instances, an enamel can cure in a fraction of a second when exposed to light, as opposed to thermally cured enamels which can require half an hour or longer. Curable materials are widely used for medical, printing, and photoresist technologies.
Changes in structural and chemical properties can be induced internally by chromophores that the polymer subunit already possesses, or externally by addition of photosensitive molecules. Typically a photopolymer consists of a mixture of multifunctional monomers and oligomers in order to achieve the desired physical properties, and therefore a wide variety of monomers and oligomers have been developed that can polymerize in the presence of light either through internal or external initiation. Photopolymers undergo a process called curing, where oligomers are cross-linked upon exposure to light, forming what is known as a network polymer. The result of photo-curing is the formation of a thermoset network of polymers. One of the advantages of photo-curing is that it can be done selectively using high energy light sources, for example lasers, however, most systems are not readily activated by light, and in this case a photoinitiator is required. Photoinitiators are compounds that upon radiation of light decompose into reactive species that activate polymerization of specific functional groups on the oligomers. An example of a mixture that undergoes cross-linking when exposed to light is shown below. The mixture consists of monomeric styrene and oligomeric acrylates.
Most commonly, photopolymerized systems are typically cured through UV radiation, since ultraviolet light is more energetic. However, the development of dye-based photoinitiator systems have allowed for the use of visible light, having the potential advantages of being simpler and safer to handle. UV curing in industrial processes has greatly expanded over the past several decades. Many traditional thermally cured and solvent-based technologies can be replaced by photopolymerization technologies. The advantages of photopolymerization over thermally cured polymerization include higher rates of polymerization and environmental benefits from elimination of volatile organic solvents.
There are two general routes for photoinitiation: free radical and ionic. The general process involves doping a batch of neat polymer with small amounts of photoinitiator, followed by selective radiation of light, resulting in a highly cross-linked product. Many of these reactions do not require solvent which eliminates termination path via reaction of initiators with solvent and impurities, in addition to decreasing the overall cost. | 0 | Theoretical and Fundamental Chemistry |
Ligand cone angles are measures of the size of ligands in coordination chemistry. It is defined as the solid angle formed with the metal at the vertex and the hydrogen atoms at the perimeter of the cone (see figure). | 0 | Theoretical and Fundamental Chemistry |
The mobile phase is composed primarily of supercritical carbon dioxide, but since CO on its own is too non-polar to effectively elute many analytes, cosolvents are added to modify the mobile phase polarity. Cosolvents are typically simple alcohols like methanol, ethanol, or isopropyl alcohol. Other solvents such as acetonitrile, chloroform, or ethyl acetate can be used as modifiers. For food-grade materials, the selected cosolvent is often ethanol or ethyl acetate, both of which are generally recognized as safe (GRAS). The solvent limitations are system and column based. | 0 | Theoretical and Fundamental Chemistry |
He was born in Solln, a borough of Munich. His parents were Karl T. Fischer, Professor of Physics at the Technical University of Munich (TU), and Valentine née Danzer. He graduated in 1937 with Abitur. Before the completion of two years' compulsory military service, the Second World War broke out, and he served in Poland, France, and Russia. During a period of study leave, towards the end of 1941 he began to study chemistry at the Technical University of Munich. Following the end of the War, he was released by the Americans in the autumn of 1945 and resumed his studies. | 0 | Theoretical and Fundamental Chemistry |
Cyclic compounds may or may not exhibit aromaticity; benzene is an example of an aromatic cyclic compound, while cyclohexane is non-aromatic. In organic chemistry, the term aromaticity is used to describe a cyclic (ring-shaped), planar (flat) molecule that exhibits unusual stability as compared to other geometric or connective arrangements of the same set of atoms. As a result of their stability, it is very difficult to cause aromatic molecules to break apart and to react with other substances. Organic compounds that are not aromatic are classified as aliphatic compounds—they might be cyclic, but only aromatic rings have especial stability (low reactivity).
Since one of the most commonly encountered aromatic systems of compounds in organic chemistry is based on derivatives of the prototypical aromatic compound benzene (an aromatic hydrocarbon common in petroleum and its distillates), the word “aromatic” is occasionally used to refer informally to benzene derivatives, and this is how it was first defined. Nevertheless, many non-benzene aromatic compounds exist. In living organisms, for example, the most common aromatic rings are the double-ringed bases in RNA and DNA. A functional group or other substituent that is aromatic is called an aryl group.
The earliest use of the term “aromatic” was in an article by August Wilhelm Hofmann in 1855. Hofmann used the term for a class of benzene compounds, many of which do have odors (aromas), unlike pure saturated hydrocarbons. Today, there is no general relationship between aromaticity as a chemical property and the olfactory properties of such compounds (how they smell), although in 1855, before the structure of benzene or organic compounds was understood, chemists like Hofmann were beginning to understand that odiferous molecules from plants, such as terpenes, had chemical properties we recognize today are similar to unsaturated petroleum hydrocarbons like benzene.
In terms of the electronic nature of the molecule, aromaticity describes a conjugated system often made of alternating single and double bonds in a ring. This configuration allows for the electrons in the molecules pi system to be delocalized around the ring, increasing the molecules stability. The molecule cannot be represented by one structure, but rather a resonance hybrid of different structures, such as with the two resonance structures of benzene. These molecules cannot be found in either one of these representations, with the longer single bonds in one location and the shorter double bond in another (See Theory below). Rather, the molecule exhibits bond lengths in between those of single and double bonds. This commonly seen model of aromatic rings, namely the idea that benzene was formed from a six-membered carbon ring with alternating single and double bonds (cyclohexatriene), was developed by August Kekulé (see History section below). The model for benzene consists of two resonance forms, which corresponds to the double and single bonds superimposing to produce six one-and-a-half bonds. Benzene is a more stable molecule than would be expected without accounting for charge delocalization. | 0 | Theoretical and Fundamental Chemistry |
While working as a researcher at Humboldt University of Berlin, Speter developed methods for extracting Thorium and Scandium. In 1911 and 1912 he registered patents on these methods. In the same years he operated a laboratory for producing Tungsten paste, then used in the manufacture of Incandescent light bulb filaments. In 1923 and 1925 he registered patents for a disinfecting lamp based on acetaldehyde. In 1927 and 1928 he studied the electrostatic properties of silk, plastic materials and synthetic textiles. The results of these studies were published in a series of articles in several professional journals. | 1 | Applied and Interdisciplinary Chemistry |
Progesterone enhances the function of serotonin receptors in the brain, so an excess or deficit of progesterone has the potential to result in significant neurochemical issues. This provides an explanation for why some people resort to substances that enhance serotonin activity such as nicotine, alcohol, and cannabis when their progesterone levels fall below optimal levels.
* Sex differences in hormone levels may induce women to respond differently than men to nicotine. When women undergo cyclic changes or different hormonal transition phases (menopause, pregnancy, adolescence), there are changes in their progesterone levels. Therefore, females have an increased biological vulnerability to nicotine's reinforcing effects compared to males and progesterone may be used to counter this enhanced vulnerability. This information supports the idea that progesterone can affect behavior.
* Similar to nicotine, cocaine also increases the release of dopamine in the brain. The neurotransmitter is involved in the reward center and is one of the main neurotransmitters involved with substance abuse and reliance. In a study of cocaine users, it was reported that progesterone reduced craving and the feeling of being stimulated by cocaine. Thus, progesterone was suggested as an agent that decreases cocaine craving by reducing the dopaminergic properties of the drug. | 0 | Theoretical and Fundamental Chemistry |
In geometry, a point group is a mathematical group of symmetry operations (isometries in a Euclidean space) that have a fixed point in common. The coordinate origin of the Euclidean space is conventionally taken to be a fixed point, and every point group in dimension d is then a subgroup of the orthogonal group O(d). Point groups are used to describe the symmetries of geometric figures and physical objects such as molecules.
Each point group can be represented as sets of orthogonal matrices M that transform point x into point y according to . Each element of a point group is either a rotation (determinant of ), or it is a reflection or improper rotation (determinant of ).
The geometric symmetries of crystals are described by space groups, which allow translations and contain point groups as subgroups. Discrete point groups in more than one dimension come in infinite families, but from the crystallographic restriction theorem and one of Bieberbach's theorems, each number of dimensions has only a finite number of point groups that are symmetric over some lattice or grid with that number of dimensions. These are the crystallographic point groups. | 0 | Theoretical and Fundamental Chemistry |
Plants rich in anthocyanins are Vaccinium species, such as blueberry, cranberry, and bilberry; Rubus berries, including black raspberry, red raspberry, and blackberry; blackcurrant, cherry, eggplant (aubergine) peel, black rice, ube, Okinawan sweet potato, Concord grape, muscadine grape, red cabbage, and violet petals. Red-fleshed peaches and apples contain anthocyanins. Anthocyanins are less abundant in banana, asparagus, pea, fennel, pear, and potato, and may be totally absent in certain cultivars of green gooseberries.
The highest recorded amount appears to be specifically in the seed coat of black soybean (Glycine max L. Merr.) containing approximately 2 g per 100 g, in purple corn kernels and husks, and in the skins and pulp of black chokeberry (Aronia melanocarpa L.) (see table). Due to critical differences in sample origin, preparation, and extraction methods determining anthocyanin content, the values presented in the adjoining table are not directly comparable.
Nature, traditional agriculture methods, and plant breeding have produced various uncommon crops containing anthocyanins, including blue- or red-flesh potatoes and purple or red broccoli, cabbage, cauliflower, carrots, and corn. Garden tomatoes have been subjected to a breeding program using introgression lines of genetically modified organisms (but not incorporating them in the final purple tomato) to define the genetic basis of purple coloration in wild species that originally were from Chile and the Galapagos Islands. The variety known as "Indigo Rose" became available commercially to the agricultural industry and home gardeners in 2012. Investing tomatoes with high anthocyanin content doubles their shelf-life and inhibits growth of a post-harvest mold pathogen, Botrytis cinerea.
Some tomatoes also have been modified genetically with transcription factors from snapdragons to produce high levels of anthocyanins in the fruits. Anthocyanins also may be found in naturally ripened olives, and are partly responsible for the red and purple colors of some olives. | 0 | Theoretical and Fundamental Chemistry |
Like chemists, chemical engineers use the unit mole extensively, but different unit multiples may be more suitable for industrial use. For example, the SI unit for volume is the cubic metre, a much larger unit than the commonly used litre in the chemical laboratory. When amount of substance is also expressed in kmol (1000 mol) in industrial-scaled processes, the numerical value of molarity remains the same, as . Chemical engineers once used the kilogram-mole (notation kg-mol), which is defined as the number of entities in 12 kg of C, and often referred to the mole as the gram-mole (notation g-mol), then defined as the number of entities in 12 g of C, when dealing with laboratory data.
Late 20th-century chemical engineering practice came to use the kilomole (kmol), which was numerically identical to the kilogram-mole (until the 2019 redefinition of SI units, which redefined the mole by fixing the value of the Avogadro constant, making it very nearly equivalent to but no longer exactly equal to the gram-mole), but whose name and symbol adopt the SI convention for standard multiples of metric units – thus, kmol means 1000 mol. This is equivalent to the use of kg instead of g. The use of kmol is not only for "magnitude convenience" but also makes the equations used for modelling chemical engineering systems coherent. For example, the conversion of a flowrate of kg/s to kmol/s only requires dividing by the molar mass in g/mol (as ) without multiplying by 1000 unless the basic SI unit of mol/s were to be used, which would otherwise require the molar mass to be converted to kg/mol.
For convenience in avoiding conversions in the imperial (or US customary units), some engineers adopted the pound-mole (notation lb-mol or lbmol), which is defined as the number of entities in 12 lb of C. One lb-mol is equal to , which is the same numerical value as the number of grams in an international avoirdupois pound.
Greenhouse and growth chamber lighting for plants is sometimes expressed in micromoles per square metre per second, where 1 mol photons ≈ photons. The obsolete unit einstein is variously defined as the energy in one mole of photons and also as simply one mole of photons. | 0 | Theoretical and Fundamental Chemistry |
Negative thermal expansion (NTE) is an unusual physicochemical process in which some materials contract upon heating, rather than expand as most other materials do. The most well-known material with NTE is water at 0 to 3.98 °C. Also, the density of solid water (ice) is lower than the density of liquid water at standard pressure. Water's NTE is the reason why water ice floats, rather than sinks, in liquid water. Materials which undergo NTE have a range of potential engineering, photonic, electronic, and structural applications. For example, if one were to mix a negative thermal expansion material with a "normal" material which expands on heating, it could be possible to use it as a thermal expansion compensator that might allow for forming composites with tailored or even close to zero thermal expansion. | 0 | Theoretical and Fundamental Chemistry |
Not all cells in a multicellular plant contain chloroplasts. All green parts of a plant contain chloroplasts—the chloroplasts, or more specifically, the chlorophyll in them are what make the photosynthetic parts of a plant green. The plant cells which contain chloroplasts are usually parenchyma cells, though chloroplasts can also be found in collenchyma tissue. A plant cell which contains chloroplasts is known as a chlorenchyma cell. A typical chlorenchyma cell of a land plant contains about 10 to 100 chloroplasts.
In some plants such as cacti, chloroplasts are found in the stems, though in most plants, chloroplasts are concentrated in the leaves. One square millimeter of leaf tissue can contain half a million chloroplasts. Within a leaf, chloroplasts are mainly found in the mesophyll layers of a leaf, and the guard cells of stomata. Palisade mesophyll cells can contain 30–70 chloroplasts per cell, while stomatal guard cells contain only around 8–15 per cell, as well as much less chlorophyll. Chloroplasts can also be found in the bundle sheath cells of a leaf, especially in C plants, which carry out the Calvin cycle in their bundle sheath cells. They are often absent from the epidermis of a leaf. | 0 | Theoretical and Fundamental Chemistry |
The process typically takes place between 900 and 1100 °C, with an anode (typically carbon) and a cathode (the oxide being reduced) in a solution of molten CaCl. Depending on the nature of the oxide it will exist at a particular potential relative to the anode, which is dependent on the quantity of CaO present in CaCl. | 0 | Theoretical and Fundamental Chemistry |
Although there appears to be a general acceptance of the basic tenet of pharmacogenomics amongst physicians and healthcare professionals, several challenges exist that slow the uptake, implementation, and standardization of pharmacogenomics. Some of the concerns raised by physicians include:
* Limitation on how to apply the test into clinical practices and treatment;
* A general feeling of lack of availability of the test;
* The understanding and interpretation of evidence-based research;
* Combining test results with other patient data for prescription optimization; and
* Ethical, legal and social issues.
Issues surrounding the availability of the test include:
* The lack of availability of scientific data: Although there are a considerable number of drug-metabolizing enzymes involved in the metabolic pathways of drugs, only a fraction have sufficient scientific data to validate their use within a clinical setting; and
* Demonstrating the cost-effectiveness of pharmacogenomics: Publications for the pharmacoeconomics of pharmacogenomics are scarce, therefore sufficient evidence does not at this time exist to validate the cost-effectiveness and cost-consequences of the test.
Although other factors contribute to the slow progression of pharmacogenomics (such as developing guidelines for clinical use), the above factors appear to be the most prevalent. Increasingly substantial evidence and industry body guidelines for clinical use of pharmacogenetics have made it a population wide approach to precision medicine. Cost, reimbursement, education, and easy use at the point of care remain significant barriers to widescale adoption. | 1 | Applied and Interdisciplinary Chemistry |
Peng Sixun (; 28 July 1919 – 9 December 2018) was a Chinese medicinal chemist.
A native of Baojing County, Peng was of Tujia descent. He graduated from the National College of Pharmacy in 1942, and completed a master's degree at Columbia University in 1950. Peng returned to teach at his alma mater, which had been renamed China Pharmaceutical University, and was elected to the Chinese Academy of Engineering in February 1996. Peng died at the age of 99 on 9 December 2018. | 1 | Applied and Interdisciplinary Chemistry |
The basic process, patented in 1922, is called the Bosch–Meiser urea process after its discoverers Carl Bosch and Wilhelm Meiser. The process consists of two main equilibrium reactions, with incomplete conversion of the reactants. The first is carbamate formation: the fast exothermic reaction of liquid ammonia with gaseous carbon dioxide () at high temperature and pressure to form ammonium carbamate ():
:(ΔH = −117 kJ/mol at 110 atm and 160 °C)
The second is urea conversion: the slower endothermic decomposition of ammonium carbamate into urea and water:
:(ΔH = +15.5 kJ/mol at 160–180 °C)
The overall conversion of and to urea is exothermic, with the reaction heat from the first reaction driving the second. The conditions that favor urea formation (high temperature) have an unfavorable effect on the carbamate formation equilibrium. The process conditions are a compromise: the ill-effect on the first reaction of the high temperature (around 190 °C) needed for the second is compensated for by conducting the process under high pressure (140–175 bar), which favors the first reaction. Although it is necessary to compress gaseous carbon dioxide to this pressure, the ammonia is available from the ammonia production plant in liquid form, which can be pumped into the system much more economically. To allow the slow urea formation reaction time to reach equilibrium, a large reaction space is needed, so the synthesis reactor in a large urea plant tends to be a massive pressure vessel. | 0 | Theoretical and Fundamental Chemistry |
Metabolic labeling of glycans can be used as a way to detect glycan structures. A well-known strategy involves the use of azide-labeled sugars which can be reacted using the Staudinger ligation. This method has been used for in vitro and in vivo imaging of glycans. | 0 | Theoretical and Fundamental Chemistry |
* The book REFRESH – life extension of existing and new welded steel structures. can be ordered under the number at FOSTA – Research Association for Steel Application Association in Germany Düsseldorf.
* Stahlbau September 2009, 78-year, ISSN 0038-9145 A6449
* IIW Recommendations for the HFMI Treatment For Improving the Fatigue Strength of Welded Joints. Autoren: Gary B. Marquis, Zuheir Barsoum, https://www.springer.com/de/book/9789811025037
*DASt-Recommendation - 026 Weld Assessment for fatigue stressed constructions, using high frequency impact hammer treatments, Stahlbau Verlags- und Service GmbH, | 1 | Applied and Interdisciplinary Chemistry |
In the United Kingdom, regulation of contaminated land comes from Part IIA of the Environmental Protection Act 1990; responsibility falls on local authorities to create a "contaminated land register". For sites with dubious past and present uses the Local Planning Authority may ask for a desktop study, which is sometimes implemented as a condition in planning applications. However by definition land that is derelict or underused is highly unlikely to be determined as contaminated land – especially due to risks to human health.
The key regulation of brownfield land is through the land use planning system when a new land use is being considered. | 1 | Applied and Interdisciplinary Chemistry |
In one version of the laser spray interface, explosive vaporization and mist formation occur when an aqueous solution effusing from the tip of the stainless steel capillary is irradiated from the opposite side of the capillary by a 10.6 μm infrared laser. Weak ion signals could be detected when the plume was sampled through the ion sampling orifice. When a high voltage (3–4 kV) was applied to the stainless-steel capillary, strong ion signals appeared. The ion abundances were found to be orders of magnitude greater than those obtained by conventional electrospray ionization in the case of aqueous solutions. This approach to laser spray ionization is a hybrid of three basic techniques for the generation of gaseous ions from the condensed phase, i.e., energy-sudden activation, nebulization and the action of an electric field.
Laser spray mass spectrometry can faithfully reflect the solution-phase characteristics of biomolecules. It has been successfully applied to evaluate the binding affinities of protein-DNA.
Laser spray has better ionization efficiency than conventional electrospray ionization (ESI). In particular, the sensitivity became more than one order of magnitude higher in negative ion modes. It was also found that this technique has a potential benefit for the low concentration samples due to condensation effect of the formed droplet by the irradiation of laser. Higher the solvation energies of triply charged metal ions, stronger are the signals for ions. | 0 | Theoretical and Fundamental Chemistry |
In many situations, especially for real water distribution networks in cities (which can extend between thousands to millions of nodes), the number of known variables (flow rates and/or head losses) required to obtain a deterministic solution will be very large. Many of these variables will not be known, or will involve considerable uncertainty in their specification. Furthermore, in many pipe networks, there may be considerable variability in the flows, which can be described by fluctuations about mean flow rates in each pipe. The above deterministic methods are unable to account for these uncertainties, whether due to lack of knowledge or flow variability.
For these reasons, a probabilistic method for pipe network analysis has recently been developed, based on the maximum entropy method of Jaynes. In this method, a continuous relative entropy function is defined over the unknown parameters. This entropy is then maximized subject to the constraints on the system, including Kirchhoff's laws, pipe friction properties and any specified mean flow rates or head losses, to give a probabilistic statement (probability density function) which describes the system. This can be used to calculate mean values (expectations) of the flow rates, head losses or any other variables of interest in the pipe network. This analysis has been extended using a reduced-parameter entropic formulation, which ensures consistency of the analysis regardless of the graphical representation of the network. A comparison of Bayesian and maximum entropy probabilistic formulations for the analysis of pipe flow networks has also been presented, showing that under certain assumptions (Gaussian priors), the two approaches lead to equivalent predictions of mean flow rates.
Other methods of stochastic optimization of water distribution systems rely on metaheuristic algorithms, such as simulated annealing and genetic algorithms. | 1 | Applied and Interdisciplinary Chemistry |
Trimethylsilylacetylene is a commonly used reagent in Sonogashira couplings. Being a liquid it is a more convenient reagent than the gaseous acetylene, and the trimethylsilyl group prevents addition onto the other end of the acetylene group. The trimethylsilyl group can then be removed using TBAF, yielding a monosubstituted acetylene. It may also be removed using DBU in situ, allowing the monosubstituted acetylene to react further with another aryl halide to form diphenylacetylene and derivatives. | 0 | Theoretical and Fundamental Chemistry |
In a sense, the study of biochemistry can be considered to have started in ancient times, for example when biology first began to interest society—as the ancient Chinese developed a system of medicine based on yin and yang, and also the five phases, which both resulted from alchemical and biological interests. Its beginning in the ancient Indian culture was linked to an interest in medicine, as they developed the concept of three humors that were similar to the Greeks four humours (see humorism). They also delved into the interest of bodies being composed of tissues. The ancient Greeks conception of biochemistry was linked with their ideas on matter and disease, where good health was thought to come from a balance of the four elements and four humors in the human body. As in the majority of early sciences, the Islamic world contributed significantly to early biological advancements as well as alchemical advancements; especially with the introduction of clinical trials and clinical pharmacology presented in Avicennas The Canon of Medicine. On the side of chemistry, early advancements were heavily attributed to exploration of alchemical interests but also included: metallurgy, the scientific method, and early theories of atomism. In more recent times, the study of chemistry was marked by milestones such as the development of Mendeleevs periodic table, Dalton's atomic model, and the conservation of mass theory. This last mention has the most importance of the three due to the fact that this law intertwines chemistry with thermodynamics in an intercalated manner. | 1 | Applied and Interdisciplinary Chemistry |
In 1909, parents sent Alexander to P. N. Strakhovs private Moscow gymnasium, which he graduated with honors. In 1917, he entered the natural department of the Faculty of Physics and Mathematics at Moscow University. There were no entrance exams due to the passage of the revolution. Studying in this difficult time required great self-sacrifice and fanatical dedication. They studied in unheated rooms and there was not enough laboratory equipment. Transport was bad, and sometimes Alexander had to walk on foot to the university from Sokolniki. In 1920, classes at Moscow State University were frozen due to problems with heating, and Nesmeyanov entered the Military Pedagogical Academy on Bolshaya Gruzinskaya Street. At the same time, he worked in the laboratories of the Shanyavsky Moscow City Peoples University. By the end of 1920, Alexander Nikolayevich returned to studies at the academy and at Moscow University, where heating had already been restored. He meets the "future scientific mentor", Professor N. D. Zelinsky. While he was working as a night watchman at the faculty, Nesmeyanov lived in the laboratory of N. D. Zelinsky and devoting all his time to scientific experiments. | 0 | Theoretical and Fundamental Chemistry |
Kinetic models describe the particle velocity distribution function at each point in the plasma and therefore do not need to assume a Maxwell–Boltzmann distribution. A kinetic description is often necessary for collisionless plasmas. There are two common approaches to kinetic description of a plasma. One is based on representing the smoothed distribution function on a grid in velocity and position. The other, known as the particle-in-cell (PIC) technique, includes kinetic information by following the trajectories of a large number of individual particles. Kinetic models are generally more computationally intensive than fluid models. The Vlasov equation may be used to describe the dynamics of a system of charged particles interacting with an electromagnetic field.
In magnetized plasmas, a gyrokinetic approach can substantially reduce the computational expense of a fully kinetic simulation. | 0 | Theoretical and Fundamental Chemistry |
At the time of development in the nineteenth century, the superscript Plimsoll symbol () was adopted to indicate the non-zero nature of the standard state. IUPAC recommends in the 3rd edition of Quantities, Units and Symbols in Physical Chemistry a symbol which seems to be a degree sign (°) as a substitute for the plimsoll mark. In the very same publication the plimsoll mark appears to be constructed by combining a horizontal stroke with a degree sign. A range of similar symbols are used in the literature: a stroked lowercase letter O () or a circle with a horizontal bar either where the bar extends beyond the boundaries of the circle () or is enclosed by the circle, dividing the circle in half (). Compared to the plimsoll symbol used in 1800s text, the U+29B5 glyph is too large and its horizontal line does not sufficiently extend beyond the boundaries of the circle. It is easily confused with the Greek letter theta (uppercase Θ or , lowercase θ ). As of 2024, the character has been proposed for Unicode. It is a regular-sized Unicode symbol meant to be used in superscripted form when denoting standard state, replacing U+29B5 for this purpose.
Ian M. Mills, who was involved in producing a revision of Quantities, Units and Symbols in Physical Chemistry, suggested that a superscript zero () is an equal alternative to indicate "standard state", though a degree symbol (°) is used in the same article. The degree symbol has come into widespread use in general, inorganic, and physical chemistry textbooks in recent years. When read out loud, the symbol is pronounced "naught". | 0 | Theoretical and Fundamental Chemistry |
Energeticism, also called energism or energetics (), is a superseded theory in science that posits that energy is the ultimate element of physical reality. Energeticism was developed during the end of the 19th century by the chemist Wilhelm Ostwald and mathematician Georg Helm. It was also promoted by physicist Ernst Mach, though his full commitment to it was sometimes ambiguous. Energetiscism attempted to substitute the hypothesis of atoms and molecules by energy relations.
Ludwig Boltzmann and Max Planck constantly rebutted the idea of energeticism in favor of atomic theory. The program of energeticism faded away in the 20th century with the confirmation of the existence of atoms. | 1 | Applied and Interdisciplinary Chemistry |
The alternative yeast nuclear code (translation table 12) is a genetic code found in certain yeasts. However, other yeast, including Saccharomyces cerevisiae, Candida azyma, Candida diversa, Candida magnoliae, Candida rugopelliculosa, Yarrowia lipolytica, and Zygoascus hellenicus, definitely use the standard (nuclear) code. | 1 | Applied and Interdisciplinary Chemistry |
The CCT evolved from the archaeal thermosome ~2Gya, with the two subunits diversifying into multiple units. The CCT changed from having one type of subunit, to having two, three, five, and finally eight types. | 1 | Applied and Interdisciplinary Chemistry |
]In terms of thermodynamics, two types of polymorphic behaviour are recognized. For a monotropic system, plots of the free energies of the various polymorphs against temperature do not cross before all polymorphs melt. As a result, any transition from one polymorph to another below the melting point will be irreversible. For an enantiotropic system, a plot of the free energy against temperature shows a crossing point before the various melting points. It may also be possible to convert interchangeably between the two polymorphs by heating or cooling, or through physical contact with a lower energy polymorph.
A simple model of polymorphism is to model the Gibbs free energy of a ball-shaped crystal as . Here, the first term is the surface energy, and the second term is the volume energy. Both parameters . The function rises to a maximum before dropping, crossing zero at . In order to crystallize, a ball of crystal much overcome the energetic barrier to the part of the energy landscape.
Now, suppose there are two kinds of crystals, with different energies and , and if they have the same shape as in Figure 2, then the two curves intersect at some . Then the system has three phases:
* . Crystals tend to dissolve. Amorphous phase.
* . Crystals tend to grow as form 1.
* . Crystals tend to grow as form 2.
If the crystal is grown slowly, it could be kinetically stuck in form 1. | 0 | Theoretical and Fundamental Chemistry |
When large turbidity currents flow into canyons they may become self-sustaining, and may entrain sediment that has previously been introduced into the canyon by littoral drift, storms or smaller turbidity currents. Canyon-flushing associated with surge-type currents initiated by slope failures may produce currents whose final volume may be several times that of the portion of the slope that has failed (e.g. Grand Banks). | 1 | Applied and Interdisciplinary Chemistry |
The purpose function of intrinsic termination is to signal for the dissociation of the ternary elongation complex (TEC), ending the transcript. Intrinsic termination independent of the protein Rho, as opposed to Rho-dependent termination, where the bacterial Rho protein comes in and acts on the RNA polymerase, causing it to dissociate. Here, there is no extra protein and the transcript forms its own loop structure. Intrinsic termination thus regulates the level of transcription as well, determining how many Polymerase can transcribe a gene over a given period of time, and can help prevent interactions with neighboring chromosomes. | 1 | Applied and Interdisciplinary Chemistry |
Heuristically, one may seek initial positions of repelling LCSs as set of initial conditions at which infinitesimal perturbations to trajectories starting from grow locally at the highest rate relative to trajectories starting off of . The heuristic element here is that instead of constructing a highly repelling material surface, one simply seeks points of large particle separation. Such a separation may well be due to strong shear along the set of points so identified; this set is not at all guaranteed to exert any normal repulsion on nearby trajectories.
The growth of an infinitesimal perturbation along a trajectory is governed by the flow map gradient . Let be a small perturbation to the initial condition , with , and with denoting an arbitrary unit vector in . This perturbation generally grows along the trajectory into the perturbation vector . Then the maximum relative stretching of infinitesimal perturbations at the point can be computed as
where denotes the right Cauchy–Green strain tensor. One then concludes that the maximum relative stretching experienced along a trajectory starting from is just . As this relative stretching tends to grow rapidly, it is more convenient to work with its growth exponent , which is then precisely the finite-time Lyapunov exponent (FTLE)
Therefore, one expects hyperbolic LCSs to appear as codimension-one local maximizing surfaces (or ridges) of the FTLE field.
This expectation turns out to be justified in the majority of cases: time positions of repelling LCSs are marked by ridges of . By applying the same argument in backward time,
we obtain that time positions of attracting LCSs are marked by ridges of the backward FTLE field .
The classic way of computing Lyapunov exponents is solving a linear differential equation for the linearized flow map . A more expedient approach is to compute the FTLE field from a simple finite-difference approximation to the deformation gradient.
For example, in a three-dimenisonal flow, we launch a trajectory from any element of a grid of initial conditions. Using the coordinate representation for the evolving trajectory , we approximate the gradient of the flow map as
with a small vector pointing in the coordinate direction. For two-dimensional flows, only the first minor matrix of the above matrix is relevant. | 1 | Applied and Interdisciplinary Chemistry |
The name derives from the German word umklappen (to turn over). Rudolf Peierls, in his autobiography Bird of Passage states he was the originator of this phrase and coined it during his 1929 crystal lattice studies under the tutelage of Wolfgang Pauli. Peierls wrote, "…I used the German term Umklapp (flip-over) and this rather ugly word has remained in use…".
The term Umklapp appears in the 1920 paper of Wilhelm Lenz's seed paper of the Ising model. | 0 | Theoretical and Fundamental Chemistry |
In steel industry
There are mainly two types of MTC in steel industry, as for steel plates or steel pipes, there must be specific inspection scope or lists:
# MTC EN 10204 3.1 :MTC 3.1 is issued by the manufacturer in which they declare that the products supplied are in compliance with the requirements of the order and in which they supply test results. This is the most common MTC in steel industry, when there is no extra requirement of customer for TPI inspection and witness of production and inspection of tests.
# MTC EN 10204 3.2 :MTC 3.2 refers to the report prepared by both the manufacturers authorized inspection representative, independent of the manufacturing department and either the purchasers authorized inspection representative or the inspector designated by the official regulations and in which they declare that the products supplied are in compliance with the requirements of the order and in which test results are supplied. | 1 | Applied and Interdisciplinary Chemistry |
Chemical reaction engineering as a discipline started in the early 1950s under the impulse of researchers at the Shell Amsterdam research center and the university of Delft. The term chemical reaction engineering was apparently coined by J.C. Vlugter while preparing the 1st European Symposium on Chemical Reaction Engineering which was held in Amsterdam in 1957. | 1 | Applied and Interdisciplinary Chemistry |
There are various protein targets of PCAF's acetyltransferase activity including transcription factors such as Fli1, p53 and numerous histone residues. Hdm2, itself a ubiquitin ligase that targets p53, has also been demonstrated to be a target of the ubiquitin-ligase activity of PCAF. | 1 | Applied and Interdisciplinary Chemistry |
Chemosphere is a biweekly peer-reviewed scientific journal published since 1972 by Elsevier and covering environmental chemistry. Its co-editors-in-chief are Jacob de Boer (Vrije Universiteit Amsterdam) and Shane Snyder (University of Arizona). The journal has a 2020 impact factor of 7.086, and is ranked 30th out of 274 journals in the category "Environmental Sciences." | 1 | Applied and Interdisciplinary Chemistry |
Natural fermentation predates human history. Since ancient times, humans have exploited the fermentation process. The earliest archaeological evidence of fermentation is 13,000-year-old residues of a beer, with the consistency of gruel, found in a cave near Haifa in Israel. Another early alcoholic drink, made from fruit, rice, and honey, dates from 7000 to 6600 BC, in the Neolithic Chinese village of Jiahu, and winemaking dates from ca. 6000 BC, in Georgia, in the Caucasus area. Seven-thousand-year-old jars containing the remains of wine, now on display at the University of Pennsylvania, were excavated in the Zagros Mountains in Iran. There is strong evidence that people were fermenting alcoholic drinks in Babylon ca. 3000 BC, ancient Egypt ca. 3150 BC, pre-Hispanic Mexico ca. 2000 BC, and Sudan ca. 1500 BC. | 1 | Applied and Interdisciplinary Chemistry |
Differences in O solubility and measured concentration (AOU) typically occur when biological activity, ocean circulation, or ocean mixing act to change the ambient concentration of oxygen. For example, primary production liberates oxygen and increases its concentration, while respiration consumes it and decreases its concentration.
Consequently, the AOU of a water sample represents the sum of the biological activity that the sample has experienced since it was last in equilibrium with the atmosphere. In shallow water systems (e.g. lakes), the full water column is generally in close contact with the atmosphere, and oxygen concentrations are typically close to saturation, and AOU values are near zero. In deep water systems (e.g. oceans), water can be out of contact with the atmosphere for extremely long periods of time (years, decades, centuries) and large positive AOU values are typical. On occasion, where near-surface primary production has raised oxygen concentrations above saturation, negative AOU values are possible (i.e. oxygen has not been utilized to below saturation concentrations). | 0 | Theoretical and Fundamental Chemistry |
Abdulrahman Obaid Al-Youbi (born 1958) was the president of King Abdulaziz University from June 2016 to October 2022. | 0 | Theoretical and Fundamental Chemistry |
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