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In the canonical pathway, Wnt proteins binds to its transmembrane receptor of the Frizzled family of proteins. The binding of Wnt to a Frizzled protein activates the Dishevelled protein. In its active state the Dishevelled protein inhibits the activity of the glycogen synthase kinase 3 (GSK3) enzyme. Normally active GS... | 1 | Gene expression + Signal Transduction |
SIN3B has been shown to interact with HDAC1, Zinc finger and BTB domain-containing protein 16, SUDS3 and IKZF1. | 1 | Gene expression + Signal Transduction |
Some assembly methods also make use of type IIs restriction endonucleases. These differ from other type II endonucleases as they cut several base pairs away from the recognition site. As a result, the overhang sequence can be modified to contain the desired sequence. This provides Type IIs assembly methods with two adv... | 1 | Gene expression + Signal Transduction |
RECODE is a database of "programmed" frameshifts, bypassing and codon redefinition used for gene expression. | 1 | Gene expression + Signal Transduction |
Fluxes are materials added to the ore during smelting to catalyze the desired reactions and to chemically bind to unwanted impurities or reaction products. Calcium carbonate or calcium oxide in the form of lime are often used for this purpose, since they react with sulfur, phosphorus, and silicon impurities to allow th... | 0 | Metallurgy |
In common use, the research definition, including post-transition metals and metalloids, is extended to include compounds such as cementite, FeC. These compounds, sometimes termed interstitial compounds, can be stoichiometric, and share similar properties to the intermetallic compounds defined above. | 0 | Metallurgy |
Activated GPCRs cause a conformational change in the attached G protein complex, which results in the G alpha subunit's exchanging GDP for GTP and separation from the beta and gamma subunits. The G alpha subunit, in turn, activates adenylyl cyclase, which quickly converts ATP into cAMP. This leads to the activation of ... | 1 | Gene expression + Signal Transduction |
While all the metals of antiquity but tin and lead occur natively, only gold and silver are commonly found as the native metal.
* Gold and silver occur frequently in their native form
* Mercury compounds are reduced to elemental mercury simply by low-temperature heating (500 °C).
* Tin and iron occur as oxides and can ... | 0 | Metallurgy |
Due to the fact that translation elongation is an irreversible process, there are few known mechanisms of its regulation. However, it has been shown that translational efficiency is reduced via diminished tRNA pools, which are required for the elongation of polypeptides. In fact, the richness of these tRNA pools are su... | 1 | Gene expression + Signal Transduction |
In coal-fired processes, part of the fuel is first burnt to heat the charge. The product of this combustion is CO. When the temperature reaches 1,000 °C, the CO reacts with the unburned carbon to create CO:
The production of H cannot be achieved by the thermal decomposition of water, as the temperatures involved are to... | 0 | Metallurgy |
The process of elongation is the synthesis of a copy of the DNA into messenger RNA. RNA Pol II matches complementary RNA nucleotides to the template DNA by Watson-Crick base pairing. These RNA nucleotides are ligated, resulting in a strand of messenger RNA.
Unlike DNA replication, mRNA transcription can involve multipl... | 1 | Gene expression + Signal Transduction |
Understanding the interfacial energy of materials with different types of interphase boundaries (IPBs) provides valuable insights into several aspects of their behavior, including thermodynamic stability, deformation behavior, and phase evolution. | 0 | Metallurgy |
DBTSS, the DataBase of Transcriptional Start Sites, is a database hosted by the Human Genome Center at the University of Tokyo. It contains the exact positions of transcriptional start sites in the genomes of various organisms. | 1 | Gene expression + Signal Transduction |
When the cost of producing slaves became too high to justify slave labourers for the many mines throughout the empire around the second century, a system of indentured servitude was introduced for convicts. In 369 AD, a law was reinstated due to the closure of many deep mines; the emperor Hadrian had previously given t... | 0 | Metallurgy |
Replication, in metallography, is the use of thin plastic films to nondestructively duplicate the microstructure of a component. The film is then examined at high magnifications.
Replication is a method of copying the topography of a surface by casting or impressing material onto the surface. It is the commonly used te... | 0 | Metallurgy |
Bases: adenine (A), cytosine (C), guanine (G) and thymine (T) or uracil (U).
Amino acids: Alanine (Ala, A), Arginine (Arg, R), Asparagine (Asn, N), Aspartic acid (Asp, D), Cysteine (Cys, C), Glutamic acid (Glu, E), Glutamine (Gln, Q), Glycine (Gly, G), Histidine (His, H), Isoleucine (Ile, I), Leucine (Leu, L), Lysine (... | 1 | Gene expression + Signal Transduction |
When a shape-memory alloy is in its cold state (below M), the metal can be bent or stretched and will hold those shapes until heated above the transition temperature. Upon heating, the shape changes to its original. When the metal cools again, it will retain the shape, until deformed again.
With the one-way effect, coo... | 0 | Metallurgy |
In an Arabidopsis thaliana study, hundreds of different proteins demonstrated the possibility to bind to CaM in plants. | 1 | Gene expression + Signal Transduction |
Plano-convex ingots are lumps of metal with a flat or slightly concave top and a convex base. They are sometimes, misleadingly, referred to as bun ingots which imply the opposite concavity. They are most often made of copper, although other materials such as copper alloy, lead and tin are used. The first examples known... | 0 | Metallurgy |
In humans, the protein is encoded by the RB1 gene located on chromosome 13—more specifically, 13q14.1-q14.2. If both alleles of this gene are mutated in a retinal cell, the protein is inactivated and the cells grow uncontrollably, resulting in development of retinoblastoma cancer, hence the "RB" in the name pRb. Thus m... | 1 | Gene expression + Signal Transduction |
Unlike LPB, traditional burnishing tools consist of a hard wheel or fixed lubricated ball pressed into the surface of an asymmetrical work piece with sufficient force to deform the surface layers, usually in a lathe. The process does multiple passes over the work pieces, usually under increasing load, to improve surfa... | 0 | Metallurgy |
In bacteria, the same enzyme catalyzes the synthesis of mRNA and non-coding RNA (ncRNA).
RNAP is a large molecule. The core enzyme has five subunits (~400 kDa):
; β′: The β′ subunit is the largest subunit, and is encoded by the rpoC gene. The β′ subunit contains part of the active center responsible for RNA synthesis a... | 1 | Gene expression + Signal Transduction |
Suppose an alloy at an equilibrium temperature T consists of mass fraction of element B. Suppose also that at temperature T the alloy consists of two phases, α and β, for which the α consists of , and β consists of . Let the mass of the α phase in the alloy be so that the mass of the β phase is , where is the tota... | 0 | Metallurgy |
The sigma-2 receptor is expressed in brain and retinal cells where it regulates key pathways involved in age-related diseases such as Alzheimers disease and synucleinopathies such as Parkinsons disease and dementia with Lewy bodies, as well as dry age-related macular degeneration (dry AMD). The normal activity of proce... | 1 | Gene expression + Signal Transduction |
A transcriptome in vivo analysis tag (TIVA tag) is a multifunctional, photoactivatable mRNA-capture molecule designed for isolating mRNA from a single cell in complex tissues.
__TOC__ | 1 | Gene expression + Signal Transduction |
In this region, the dominant deformation mechanism is power law creep, such that the strain rate goes as the stress raised to a stress exponent n. This region is dominated by dislocation creep. The value of this stress exponent is dependent upon the material and the microstructure. If deformation is occurring by slip,... | 0 | Metallurgy |
Disrupting pRb expression in vitro, either by gene deletion or knockdown of pRb short interfering RNA, causes dendrites to branch out farther. In addition, Schwann cells, which provide essential support for the survival of neurons, travel with the neurites, extending farther than normal. The inhibition of pRb supports ... | 1 | Gene expression + Signal Transduction |
A non-competitive antagonist is a type of insurmountable antagonist that may act in one of two ways: by binding to an allosteric site of the receptor, or by irreversibly binding to the active site of the receptor. The former meaning has been standardised by the IUPHAR, and is equivalent to the antagonist being called a... | 1 | Gene expression + Signal Transduction |
Bulat is a type of steel alloy known in Russia from medieval times; it was regularly mentioned in Russian legends as the material of choice for cold steel. The name булат is a Russian transliteration of the Persian word fulad, meaning steel. This type of steel was used by the armies of nomadic peoples. Bulat steel was ... | 0 | Metallurgy |
Various techniques are used in the investigative process of metallurgical failure analysis.
* Macroscopic examination: camera, stereoscope
* Microscopic examination: light microscopy, electron microscopy, x-ray microscopy, metallographic etching
* Mechanical testing: hardness testing, tensile testing, Charpy impact tes... | 0 | Metallurgy |
Founded as the American Institute of Mining Engineers (AIME), the institute had a membership at the beginning of 1915 of over 5,000, made up of honorary, elected, and associate members. The annual meeting of the institute was held in February, with other meetings during the year as authorized by the council. The inst... | 0 | Metallurgy |
The touchstone method is most common by far and does not damage the item in question. A rubbing of the item is made on a special stone, treated with acids and the result is compared to the result of the same process done on a sample of gold with a known purity. Red radiolarian chert or black siliceous slate were used f... | 0 | Metallurgy |
The practice of tin mining likely began circa 3000 B.C. in Western Asia, British Isles and Europe. Tin was an essential ingredient of bronze production during the Bronze Age.
The practice of tinning ironware to protect it against rust is an ancient one. This may have been the work of the whitesmith. This was done after... | 0 | Metallurgy |
In mammals, the eIF4E•G•A trimeric complex can be directly purified from cells, while only the two subunit eIF4E•G can be purified from yeast cells. eIF4E binds the mG 5 cap and the eIF4G scaffold, connecting the mRNA 5 terminus to a hub of other initiation factors and mRNA. The interaction of eIF4G•A is thought to gui... | 1 | Gene expression + Signal Transduction |
The compound's band structure exhibits a double Dirac cone, enabling Dirac fermions. A 30 meV gap separates the cones, which indicates the quantum Hall effect and massive Dirac fermions. Close measurement of the Fermi surface via the de Haas-van Alphen effect suggests that the massive fermions also exhibit Kane-Mele-... | 0 | Metallurgy |
The maintenance of heterochromatin regions by RITS complexes has been described as a self-reinforcing feedback loop, in which RITS complexes stably bind the methylated histones of a heterochromatin region using the Chp1 protein and induce co-transcriptional degradation of any nascent messenger RNA (mRNA) transcripts, w... | 1 | Gene expression + Signal Transduction |
The first reported metallic glass was an alloy (AuSi) produced at Caltech by W. Klement (Jr.), Willens and Duwez in 1960. This and other early glass-forming alloys had to be cooled extremely rapidly (on the order of one megakelvin per second, 10 K/s) to avoid crystallization. An important consequence of this was that m... | 0 | Metallurgy |
Due to the binding capabilities of antipsychotic drugs and various neurotransmitters associated with mood, the sigma-2 receptor is a viable target for therapies related to neuropsychiatric disorders and modulation of emotional response. It is thought to be involved in the pathophysiology of schizophrenia, and sigma-2 r... | 1 | Gene expression + Signal Transduction |
When inactive, the PKA apoenzyme exists as a tetramer which consists of two regulatory subunits and two catalytic subunits. The catalytic subunit contains the active site, a series of canonical residues found in protein kinases that bind and hydrolyse ATP, and a domain to bind the regulatory subunit. The regulatory sub... | 1 | Gene expression + Signal Transduction |
SMAs display a phenomenon sometimes called superelasticity, but is more accurately described as pseudoelasticity. “Superelasticity” implies that the atomic bonds between atoms stretch to an extreme length without incurring plastic deformation. Pseudoelasticity still achieves large, recoverable strains with little to no... | 0 | Metallurgy |
eIF2 activity is regulated by a mechanism involving both guanine nucleotide exchange and phosphorylation. Phosphorylation takes place at the α-subunit, which is a target for a number of serine kinases that phosphorylate serine 51. Those kinases act as a result of stress such as amino acid deprivation (GCN2), ER stress ... | 1 | Gene expression + Signal Transduction |
Work hardening is a consequence of plastic deformation, a permanent change in shape. This is distinct from elastic deformation, which is reversible. Most materials do not exhibit only one or the other, but rather a combination of the two. The following discussion mostly applies to metals, especially steels, which are w... | 0 | Metallurgy |
Thaumasite is a calcium silicate mineral, containing Si atoms in unusual octahedral configuration, with chemical formula CaSi(OH)(CO)(SO)·12HO, also sometimes more simply written as CaSiO·CaCO·CaSO·15HO.
Thaumasite is formed under special conditions in the presence of sulfate ions in concrete containing, or exposed to,... | 0 | Metallurgy |
In the iron–carbon system (i.e. plain-carbon steels and cast irons) it is a common constituent because ferrite can contain at most 0.02wt% of uncombined carbon. Therefore, in carbon steels and cast irons that are slowly cooled, a portion of the carbon is in the form of cementite. Cementite forms directly from the melt ... | 0 | Metallurgy |
Heparin and heparan sulfate (HS) are mammalian glycosaminoglycans with the highest negative charge density of known biological macromolecules. They bind by ionic interactions with a variety of proteins. Heparin is widely used as an injectable anticoagulant. SFRP1 are heparin-binding proteins, with the heparin-bindin... | 1 | Gene expression + Signal Transduction |
Initially, the chemical reactions that normally occur in the cement paste, generate an alkaline environment, bringing the solution in the cement paste pores to pH values around 13. In these conditions, passivation of steel rebar occurs, due to a spontaneous generation of a thin film of oxides able to protect the steel ... | 0 | Metallurgy |
Poroma is a benign, relatively common skin tumor that has the cellular features similar to those of a sweat gland duct. This tumor typically occurs as a solitary stalkless nodule on the soles and palms but may occur in any area where there are sweat glands. Porocarcinoma (also termed eccrine porocarcinoma and malignant... | 1 | Gene expression + Signal Transduction |
The LHCG receptor's main function is the regulation of steroidogenesis. This is accomplished by increasing the intracellular levels of the enzyme cholesterol side chain cleaving enzyme, a member of the cytochrome P450 family. This leads to increased conversion of cholesterol into androgen precursors required to make ma... | 1 | Gene expression + Signal Transduction |
Based on the principle of counter-current piston flow, these processes are the closest to the blast furnace or, more accurately, the stückofen. Hot reducing gases are obtained from natural gas, in a separate unit from the shaft, and injected at the bottom of the shaft, while the ore is charged at the top. The pre-reduc... | 0 | Metallurgy |
Since microsphere beads are easily suspended in solution and each microsphere retains its identity when hybridized to the test sample, a typical suspension array experiment can analyze a wide range of biological analysis in a single reaction, called "multiplexing". In general, each type of microsphere used in an array ... | 1 | Gene expression + Signal Transduction |
Eutectic NaK (NaK-77, an alloy of 77% potassium and 23% sodium by mass) can be used as a hydraulic fluid in high-temperature and high-radiation environments, for temperature ranges of . Its bulk modulus at is 2.14 GPa, higher than of a hydraulic oil at room temperature. Its lubricity is poor, so positive-displacement ... | 0 | Metallurgy |
mTOR is the catalytic subunit of two structurally distinct complexes: mTORC1 and mTORC2. The two complexes localize to different subcellular compartments, thus affecting their activation and function. Upon activation by Rheb, mTORC1 localizes to the Ragulator-Rag complex on the lysosome surface where it then becomes ac... | 1 | Gene expression + Signal Transduction |
Conferences are normally scheduled for May or June in Europe, North America or Asia. However, most conferences are held in Europe because the majority of the current membership resides in Europe. Conferences start with an informal reception on Sunday evening followed by two and a half days of technical sessions. Ample ... | 0 | Metallurgy |
After a cell passes the restriction point, Cyclin E - Cdk 2 hyper-phosphorylates all mono-phosphorylated isoforms. While the exact mechanism is unknown, one hypothesis is that binding to the C-terminus tail opens the pocket subunit, allowing access to all phosphorylation sites. This process is hysteretic and irreversib... | 1 | Gene expression + Signal Transduction |
Friction stir processing (FSP) is a method of changing the properties of a metal through intense, localized plastic deformation. This deformation is produced by forcibly inserting a non-consumable tool into the workpiece, and revolving the tool in a stirring motion as it is pushed laterally through the workpiece. The p... | 0 | Metallurgy |
Because of anisomycins wide use as a protein synthesis inhibitor, there have been many studies centered on the biosynthesis of anisomycin. One study by Butler in 1974 proposed possible precursors to this natural product. Fermentation of Streptomyces' with labeled amino acids was followed by a degradation of the radioac... | 1 | Gene expression + Signal Transduction |
The Golden Gate assembly protocol was defined by Engler et al. 2008 to define a DNA assembly method that would give a final construct without a scar sequence, while also lacking the original restriction sites. This allows the protein to be expressed without containing unwanted protein sequences which could negatively a... | 1 | Gene expression + Signal Transduction |
The functional mammalian sAC consist of two heterologous catalytic domains (C1 and C2), forming the 50 kDa amino terminus of the protein. The additional ~140 kDa C terminus of the enzyme includes an autoinhibitory region, canonical P-loop, potential heme-binding domain, and leucine zipper-like sequence, which are a for... | 1 | Gene expression + Signal Transduction |
mTOR Complex 1 (mTORC1) is composed of mTOR, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8 (mLST8) and the non-core components PRAS40 and DEPTOR. This complex functions as a nutrient/energy/redox sensor and controls protein synthesis. The activity of mTORC1 is regulated by rapa... | 1 | Gene expression + Signal Transduction |
The Dhar iron pillar is a now-fragmented iron column located in the Dhar town of Madhya Pradesh, India. The exact origins of the pillar are unknown, but according to the local tradition, it was a victory column erected by the 11th century Paramara king Bhoja.
Three of its fragments are now located near the 15th century... | 0 | Metallurgy |
Tetrathionate is a product of the oxidation of thiosulfate, , by iodine, I:
:2 + I → + 2I
The use of bromine instead of iodine is dubious as excess bromine will oxidize the thiosulfate to sulfate. | 0 | Metallurgy |
Mechanistically, eukaryotic translation termination matches its prokaryotic counterpart. In this case, termination of the polypeptide chain is achieved through the hydrolytic action of a heterodimer consisting of release factors, eRF1 and eRF3. Translation termination is said to be leaky in some cases as noncoding-tRNA... | 1 | Gene expression + Signal Transduction |
In 2021, calcium was the 243rd most commonly prescribed medication in the United States, with more than 1million prescriptions. | 1 | Gene expression + Signal Transduction |
The Sepro Leach Reactor is a high concentration leach reactor developed to treat the gold concentrate produced by the Falcon Concentrator. The unit consists of a concentrate holding tank and a leach tank and impeller which are linked by a Sepro vertical bowl pump. The SLR uses either peroxide or oxygen gas to achieve e... | 0 | Metallurgy |
Several single nucleotide polymorphisms within the TCF7L2 gene have been associated with type 2 diabetes. Studies conducted by Ravindranath Duggirala and Michael Stern at The University of Texas Health Science Center at San Antonio were the first to identify strong linkage for type 2 diabetes at a region on Chromosome ... | 1 | Gene expression + Signal Transduction |
Pol III has three classes of initiation, which start with different factors recognizing different control elements but all converging on TFIIIB (similar to TFIIB-TBP; consists of TBP/TRF, a TFIIB-related factor, and a B″ unit) recruiting the Pol III preinitiation complex. The overall architecture resembles that of Pol ... | 1 | Gene expression + Signal Transduction |
Recovery of metals from oxide matrixes is generally carried out using mineral acids. However, electrochemical dissolution of metal oxides in DES can allow to enhance the dissolution up to more than 10 000 times in pH neutral solutions.
Studies have shown that ionic oxides such as ZnO tend to have high solubility in ChC... | 0 | Metallurgy |
Humans and chimpanzees share ten NANOG pseudogenes (NanogP2-P11) during evaluation, two of them are located on the X chromosome and they characterized by the 5’ promoter sequences and the absence of introns as a result of mRNA retrotransposition all in the same places: one duplication pseudogene and nine retropseudogen... | 1 | Gene expression + Signal Transduction |
Tribocorrosion is a material degradation process due to the combined effect of corrosion and wear. The name tribocorrosion expresses the underlying disciplines of tribology and corrosion. Tribology is concerned with the study of friction, lubrication and wear (its name comes from the Greek "tribo" meaning to rub) and c... | 0 | Metallurgy |
Shadow enhancers are groups of two or more enhancers that control the same target gene and drive overlapping spatiotemporal expression patterns. Shadow enhancers are found in a wide range of organisms, from insects to plants to mammals, particularly in association with developmental genes. While seemingly redundant, th... | 1 | Gene expression + Signal Transduction |
The Betts electrolytic process is an industrial process for purification of lead from bullion. Lead obtained from its ores is impure because lead is a good solvent for many metals. Often these impurities are tolerated, but the Betts electrolytic process is used when high purity lead is required, especially for bismut... | 0 | Metallurgy |
The CD family of co-receptors are a well-studied group of extracellular receptors found in immunological cells. The CD receptor family typically act as co-receptors, illustrated by the classic example of CD4 acting as a co-receptor to the T cell receptor (TCR) to bind major histocompatibility complex II (MHC-II). This ... | 1 | Gene expression + Signal Transduction |
The most common type of frameshifting is −1 frameshifting or programmed −1 ribosomal frameshifting (−1 PRF). Other, rarer types of frameshifting include +1 and −2 frameshifting. −1 and +1 frameshifting are believed to be controlled by different mechanisms, which are discussed below. Both mechanisms are kinetically driv... | 1 | Gene expression + Signal Transduction |
Communication between neurons happens primarily through chemical neurotransmission at the synapse. Neurotransmitters are packaged into synaptic vesicles for release from the presynaptic cell into the synapse, from where they diffuse and can bind to postsynaptic receptors. While most presynaptic cells are historically t... | 1 | Gene expression + Signal Transduction |
P. aeruginosa is an opportunistic human pathogen associated with cystic fibrosis. In P. aeruginosa infections, quorum sensing is critical for biofilm formation and pathogenicity. P. aeruginosa contains two pairs of LuxI/LuxR homologs, LasI/LasR and RhlI, RhlR. LasI and RhlI are synthase enzymes that catalyze the s... | 1 | Gene expression + Signal Transduction |
It may be necessary to repair a concrete structure following damage (e.g. due to age, chemical attack, fire, impact, movement or reinforcement corrosion). Strengthening may be necessary if the structure is weakened (e.g. due to design or construction errors, excessive loading, or because of a change of use). | 0 | Metallurgy |
Sealants are an alternative to solder where additional strength is not required. In most cases, sealants should not be necessary with a properly designed copper installation. They are at best a relatively short-term solution requiring frequent maintenance. Regardless, sealant-filled joints have been used successfully a... | 0 | Metallurgy |
Thiosulfate ion is known in the very rare mineral sidpietersite . The presence of this anion in the mineral bazhenovite was disputed. | 0 | Metallurgy |
Alloy systems that are liquid at room temperature have thermal conductivity far superior to ordinary non-metallic liquids, allowing liquid metal to efficiently transfer energy from the heat source to the liquid. They also have a higher electrical conductivity that allows the liquid to be pumped more efficiently, by ele... | 0 | Metallurgy |
Electrowinning, also called electroextraction, is the electrodeposition of metals from their ores that have been put in solution via a process commonly referred to as leaching. Electrorefining uses a similar process to remove impurities from a metal. Both processes use electroplating on a large scale and are important ... | 0 | Metallurgy |
Symplekin (SYMPK) is a scaffolding protein that mediates the interaction between CPSF and CstF.
In mammalian CPSF, both cleavage factor I (CFI) and cleavage and polyadenylation specificity factor (CPSF) are required for cleavage and polyadenylation whereas cleavage stimulation factor (CstF) is only essential for the cl... | 1 | Gene expression + Signal Transduction |
The process of detonation spraying was first developed in 1955 by H.B. Sargent, R.M. Poorman and H. Lamprey and was subsequently patented. It was first made commercially available as the D-Gun Process by Union Carbide in the same year. It was further developed in the 1960s by the Paton Institute in Kiev (Ukraine), into... | 0 | Metallurgy |
The ascidian mitochondrial code (translation table 13) is a genetic code found in the mitochondria of Ascidia. | 1 | Gene expression + Signal Transduction |
While many of the proteins involved in NMD are not conserved between species, in Saccharomyces cerevisiae (yeast), there are three main factors in NMD: UPF1, UPF2 and UPF3 (UPF3A and UPF3B in humans), that make up the conserved core of the NMD pathway. All three of these factors are trans-acting elements called up-fram... | 1 | Gene expression + Signal Transduction |
A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes. The activator contains a DNA binding domain that binds either to a DNA promoter site or a specific DNA regulatory sequence called an enhancer. Bindi... | 1 | Gene expression + Signal Transduction |
The sequence of exon 1 is highly conserved in mammalian species and editing of the pre-mRNA of this protein is likely to occur in mice, rat, dog and cow as well as humans. Even though the ECS is not conserved in non-mammals, an alternative ECS has been predicted in Zebrafish with a similar structure but in a different... | 1 | Gene expression + Signal Transduction |
HVAF coating technology is the combustion of propane in a compressed air stream. Like HVOF, this produces a uniform high velocity jet. HVAF differs by including a heat baffle to further stabilize the thermal spray mechanisms. Material is injected into the air-fuel stream and coating particles are propelled toward the p... | 0 | Metallurgy |
Nuclear receptor coactivator 4, also known as Androgen Receptor Activator (ARA70), is a protein that in humans is encoded by the NCOA4 gene. It plays an important role in ferritinophagy, acting as a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome. | 1 | Gene expression + Signal Transduction |
Correct selection of the material by the design engineer affects the design life of a structure. Sometimes stainless steel is not the correct choice and carbon steel would be better. There is a misconception that stainless steel has excellent corrosion resistance and will not corrode. This is not always the case and sh... | 0 | Metallurgy |
* Birchons Dictionary of Metallurgy', London, 1965
* Experimental techniques in low-temperature physics, G. K. White, Oxford University Press, Third Edition | 0 | Metallurgy |
ORs, which are located on the membranes of the cilia have been classified as a complex type of ligand-gated metabotropic channels. There are approximately 1000 different genes that code for the ORs, making them the largest gene family. An odorant will dissolve into the mucus of the olfactory epithelium and then bind ... | 1 | Gene expression + Signal Transduction |
After the war, the engineers evacuated from the western regions returned to their native places, which led to a shortage of engineering and technical personnel at Ural enterprises. Also, the Urals experienced a lack of funding for the reconversion of factories, since the bulk of the funds were directed to the restorati... | 0 | Metallurgy |
*ATF1 NM_005171
*ATF2 NM_001880
*ATF4 Activating transcription factor 4 NM_001675
*ATF6 NM_007348
*ATF7 NM_001206682
*ATF7IP NM_018179
*BTF3 NM_001207 Homo sapiens basic transcription factor 3
*E2F4 Homo sapiens E2F transcription factor 4, p107/p130-binding (E2F4), mRNA
*ERH (gene) Enhancer of rudimentary homolog of d... | 1 | Gene expression + Signal Transduction |
With the determination of the first structure of the complex between a G-protein coupled receptor (GPCR) and a G-protein trimer (Gαβγ) in 2011 a new chapter of GPCR research was opened for structural investigations of global switches with more than one protein being investigated. The previous breakthroughs involved det... | 1 | Gene expression + Signal Transduction |
Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein is a key regulator which modulates transcriptional activity of a variety of transcription factors, including the estro... | 1 | Gene expression + Signal Transduction |
The important characteristic of these tests is that the strain rate is low, for example extension rates selected in the range from 10 to 10 s. The selection of the strain rate is very important because the susceptibility to cracking may not be evident from result of tests at too low or too high strain rate. For numerou... | 0 | Metallurgy |
There are various protein targets of PCAF's acetyltransferase activity including transcription factors such as Fli1, p53 and numerous histone residues. Hdm2, itself a ubiquitin ligase that targets p53, has also been demonstrated to be a target of the ubiquitin-ligase activity of PCAF. | 1 | Gene expression + Signal Transduction |
Cementite (or iron carbide) is a compound of iron and carbon, more precisely an intermediate transition metal carbide with the formula FeC. By weight, it is 6.67% carbon and 93.3% iron. It has an orthorhombic crystal structure. It is a hard, brittle material, normally classified as a ceramic in its pure form, and is a ... | 0 | Metallurgy |
Nickel and copper are often obtained by electrowinning. These metals have some noble character, which enables their soluble cationic forms to be reduced to their pure metallic form at mild applied potentials applied between the cathode and the anode. | 0 | Metallurgy |
YeTFaSCo (The Yeast Transcription Factor Specificity Compendium) is a database of transcription factors for Saccharomyces cerevisiae. | 1 | Gene expression + Signal Transduction |
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