instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'A cDNA encoding human delta-aminolevulinic acid dehydratase (ALA-D; EC 4.2.1.24), the second enzyme in the heme biosynthetic pathway, was isolated from a human liver cDNA expression library.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [delta-aminolevulinic acid dehydratase; ala-d]
<Options>: A: aminolevulinate dehydratase (sus scrofa) (aka aminolevulinate dehydratase)
B: alad.s (xenopus laevis) (aka aminolevulinate dehydratase s homeolog)
C: aminolevulinate dehydratase (bos taurus) (aka aminolevulinate dehydratase)
D: alad (xenopus laevi... | [I; I] |
<Instruct>: Given the context 'A cDNA encoding human delta-aminolevulinic acid dehydratase (ALA-D; EC 4.2.1.24), the second enzyme in the heme biosynthetic pathway, was isolated from a human liver cDNA expression library.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [delta-aminolevulinic acid dehydratase; ala-d]
<Options>: A: aminolevulinate, delta-, dehydratase (mus musculus) (aka aminolevulinate, delta-, dehydratase)
B: aaopd (homo sapiens) (aka parkinson disease 10 (susceptibility))
C: aminolevulinate dehydratase (oryctolagus cuniculus) (aka aminolevulinate dehydrat... | [D; D] |
<Instruct>: Given the context 'Of the original 17 clones selected with anti-ALA-D antibody, only four expressed anti-ALA-D epitopes as assessed by rescreening with antibody preabsorbed with purified antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [ala-d]
<Options>: A: alad.l (xenopus laevis) (aka aminolevulinate dehydratase l homeolog)
B: alad (homo sapiens) (aka aminolevulinate dehydratase)
C: alad (glycine max) (aka aminolevulinate, delta-, dehydratase)
D: aard (homo sapiens) (aka alanine and arginine rich domain containing protein)
E: aladin (hom... | [B] |
<Instruct>: Given the context 'The aa sequence predicted from the partial nucleotide sequence was found to be essentially colinear with the sequences of four bovine ALA-D peptides, totaling 35 non-overlapping aa residues.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [ala-d]
<Options>: A: alad (glycine max) (aka aminolevulinate, delta-, dehydratase)
B: alad (homo sapiens) (aka aminolevulinate dehydratase)
C: aaopd (homo sapiens) (aka parkinson disease 10 (susceptibility))
D: alad.s (xenopus laevis) (aka aminolevulinate dehydratase s homeolog)
E: aard (homo sapiens) (aka... | [F] |
<Instruct>: Given the context '6-Phosphogluconolactonase deficiency, a hereditary erythrocyte enzyme deficiency: possible interaction with glucose-6-phosphate dehydrogenase deficiency.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [6-phosphogluconolactonase; glucose-6-phosphate dehydrogenase]
<Options>: A: 6-phosphogluconolactonase (homo sapiens) (aka 6-phosphogluconolactonase)
B: 6-phosphogluconate phosphatase (escherichia coli str. k-12 substr. mg1655) (aka 6-phosphogluconate phosphatase)
C: 6pgd (homo sapiens) (aka phosphogluconat... | [A; J] |
<Instruct>: Given the context '6-Phosphogluconolactonase deficiency, a hereditary erythrocyte enzyme deficiency: possible interaction with glucose-6-phosphate dehydrogenase deficiency.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [6-phosphogluconolactonase; glucose-6-phosphate dehydrogenase]
<Options>: A: 6-phosphogluconolactonase (homo sapiens) (aka 6-phosphogluconolactonase)
B: 6pgd (homo sapiens) (aka phosphogluconate dehydrogenase)
C: udp-glucose 6-dehydrogenase (homo sapiens) (aka udp-glucose 6-dehydrogenase)
D: glucose-6-phosp... | [A; I] |
<Instruct>: Given the context 'Partial deficiency of 6-phosphogluconolactonase (EC 3.1.1.31) of the erythrocytes was discovered as an autosomal dominant disorder.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [6-phosphogluconolactonase]
<Options>: A: 6-phosphogluconolactonase (gallus gallus) (aka 6-phosphogluconolactonase)
B: 6-phosphogluconolactonase (homo sapiens) (aka 6-phosphogluconolactonase)
C: 6-phosphogluconolactonase (bos taurus) (aka 6-phosphogluconolactonase)
D: 6-phosphogluconolactonase (xenopus trop... | [B] |
<Instruct>: Given the context 'Hemolytic anemia occurred in an individual who had inherited both the gene for 6-phosphogluconolactonase deficiency and that for deficiency of a nonhemolytic variant of glucose-6-phosphate dehydrogenase (EC 1.1.1.49).', select the correct biomedical concept for each mention using the prov... | <Mentions>: [6-phosphogluconolactonase; glucose-6-phosphate dehydrogenase]
<Options>: A: glucose-6-phosphate dehydrogenase (saccharomyces cerevisiae s288c) (aka glucose-6-phosphate dehydrogenase)
B: 6-phosphogluconolactonase (sus scrofa) (aka 6-phosphogluconolactonase)
C: 6pgd (homo sapiens) (aka phosphogluconate dehyd... | [G; I] |
<Instruct>: Given the context 'Hemolytic anemia occurred in an individual who had inherited both the gene for 6-phosphogluconolactonase deficiency and that for deficiency of a nonhemolytic variant of glucose-6-phosphate dehydrogenase (EC 1.1.1.49).', select the correct biomedical concept for each mention using the prov... | <Mentions>: [6-phosphogluconolactonase; glucose-6-phosphate dehydrogenase]
<Options>: A: glucose-6-phosphate dehydrogenase (xenopus tropicalis) (aka glucose-6-phosphate dehydrogenase)
B: glucose-6-phosphate dehydrogenase (danio rerio) (aka glucose-6-phosphate dehydrogenase)
C: 6-phosphogluconolactonase (homo sapiens) (... | [C; D] |
<Instruct>: Given the context 'It is proposed that the interaction of this hereditary erythrocyte abnormality with glucose-6-phosphate dehydrogenase deficiency may explain hemolysis in some other patients who have inherited polymorphic variants of glucose-6-phosphate dehydrogenase.', select the correct biomedical conce... | <Mentions>: [glucose-6-phosphate dehydrogenase]
<Options>: A: glucose-6-phosphate 1-dehydrogenase (caenorhabditis elegans) (aka glucose-6-phosphate 1-dehydrogenase)
B: glucose-6-phosphate dehydrogenase (xenopus tropicalis) (aka glucose-6-phosphate dehydrogenase)
C: 6pgd (homo sapiens) (aka phosphogluconate dehydrogenas... | [D] |
<Instruct>: Given the context 'Human muscle phosphoglycerate mutase deficiency: newly discovered metabolic myopathy.
Muscle phosphoglycerate mutase activity was decreased (5.7 percent of the lowest control value) in a 52-year-old man with intolerance for strenuous exercise and recurrent pigmenturia since adolescence.',... | <Mentions>: [muscle phosphoglycerate mutase]
<Options>: A: phosphoglycerate mutase elevated 2 (mus musculus) (aka phosphoglycerate mutase elevated 2)
B: pgam-m (homo sapiens) (aka phosphoglycerate mutase 2)
C: phosphoglycerate mutase 1 (homo sapiens) (aka phosphoglycerate mutase 1)
D: phosphoglycerate mutase 1 (mus mus... | [B] |
<Instruct>: Given the context 'Electrophoretic, heat lability, and mercury inhibition studies showed that the small residual activity in the patient's muscle was represented by the brain (BB) isoenzyme of phosphoglycerate mutase, suggesting a genetic defect of the M subunit which predominates in normal muscle.', select... | <Mentions>: [brain (bb) isoenzyme of phosphoglycerate mutase]
<Options>: A: bisphosphoglycerate mutase (homo sapiens) (aka bisphosphoglycerate mutase)
B: pgam-b (homo sapiens) (phosphoglycerate mutase 1 (homo sapiens)) (aka phosphoglycerate mutase 1)
C: pgam-b (homo sapiens) (phosphoglycerate mutase family member 4 (ho... | [B] |
<Instruct>: Given the context 'Linkage of the LW blood group locus with the complement C3 and Lutheran blood group loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lw blood group; complement c3; lutheran blood group]
<Options>: A: lulu (xenopus tropicalis) (aka erythrocyte membrane protein band 4.1 like 5)
B: ly6l (bos taurus) (aka lymphocyte antigen 6 family member l)
C: apolipoprotein c3 (homo sapiens) (aka apolipoprotein c3)
D: basal cell adhesion molecule (luther... | [L; F; D] |
<Instruct>: Given the context 'Linkage of the LW blood group locus with the complement C3 and Lutheran blood group loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lw blood group; complement c3; lutheran blood group]
<Options>: A: c3 (homo sapiens) (aka complement c3)
B: lu (danio rerio) (aka basal cell adhesion molecule (lutheran blood group))
C: complement component 3 (gallus gallus) (aka complement component 3)
D: basal cell adhesion molecule (lutheran blood group... | [E; A; H] |
<Instruct>: Given the context 'Linkage of the LW blood group locus with the complement C3 and Lutheran blood group loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lw blood group; complement c3; lutheran blood group]
<Options>: A: basal cell adhesion molecule (lutheran blood group) (homo sapiens) (aka basal cell adhesion molecule (lutheran blood group))
B: basal cell adhesion molecule (lutheran blood group) l homeolog (xenopus laevis) (aka basal cell adhesion molecul... | [D; G; A] |
<Instruct>: Given the context 'Segregation data on LW in families of informative males show that the LW (Landsteiner-Wiener) blood group locus is closely linked to the complement C3 locus and to the locus for the Lutheran blood group.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [lw; lw (landsteiner-wiener) blood group; complement c3; lutheran blood group]
<Options>: A: lvwm (homo sapiens) (aka eukaryotic translation initiation factor 2b subunit epsilon)
B: opn1lw (bos taurus) (aka opsin 1, long wave sensitive)
C: apo-c3 (homo sapiens) (aka apolipoprotein c3)
D: lwr (drosophila mel... | [E; E; N; Q] |
<Instruct>: Given the context 'Segregation data on LW in families of informative males show that the LW (Landsteiner-Wiener) blood group locus is closely linked to the complement C3 locus and to the locus for the Lutheran blood group.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [lw; lw (landsteiner-wiener) blood group; complement c3; lutheran blood group]
<Options>: A: lulu (xenopus tropicalis) (aka erythrocyte membrane protein band 4.1 like 5)
B: basal cell adhesion molecule (lutheran blood group) (xenopus tropicalis) (aka basal cell adhesion molecule (lutheran blood group))
C: c... | [O; O; C; E] |
<Instruct>: Given the context 'Segregation data on LW in families of informative males show that the LW (Landsteiner-Wiener) blood group locus is closely linked to the complement C3 locus and to the locus for the Lutheran blood group.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [lw; lw (landsteiner-wiener) blood group; complement c3; lutheran blood group]
<Options>: A: lu (bos taurus) (aka basal cell adhesion molecule)
B: lw (drosophila melanogaster) (aka long wing)
C: lvwm (homo sapiens) (aka eukaryotic translation initiation factor 2b subunit epsilon)
D: basal cell adhesion mole... | [N; N; J; L] |
<Instruct>: Given the context 'Segregation data on LW in families of informative males show that the LW (Landsteiner-Wiener) blood group locus is closely linked to the complement C3 locus and to the locus for the Lutheran blood group.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [lw; lw (landsteiner-wiener) blood group; complement c3; lutheran blood group]
<Options>: A: lu (danio rerio) (aka basal cell adhesion molecule (lutheran blood group))
B: gwl (bos taurus) (aka microtubule associated serine/threonine kinase like)
C: lulu (xenopus tropicalis) (aka erythrocyte membrane protein... | [M; M; Q; N] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [apoe; le; c3; lw]
<Options>: A: lw (drosophila melanogaster) (aka long wing)
B: apoer (homo sapiens) (aka ldl receptor related protein 1)
C: leo1 homolog, paf1/rna polymerase ii complex component s homeolog (xenopus laevis) (aka leo1 homolog, paf1/rna polymerase ii complex component s homeolog)
D: apo-e (h... | [D; J; L; T] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [apoe; le; c3; lw]
<Options>: A: apolipoprotein h (homo sapiens) (aka apolipoprotein h)
B: complement component 3 (gallus gallus) (aka complement component 3)
C: apolipoprotein o (homo sapiens) (aka apolipoprotein o)
D: apoer (homo sapiens) (aka ldl receptor related protein 1)
E: apolipoprotein e (homo sapi... | [E; M; L; F] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [apoe; le; c3; lw]
<Options>: A: complement component 3 (gallus gallus) (aka complement component 3)
B: c3b (homo sapiens) (aka complement c3)
C: leo1 homolog, paf1/rna polymerase ii complex component l homeolog (xenopus laevis) (aka leo1 homolog, paf1/rna polymerase ii complex component l homeolog)
D: lipa... | [L; P; B; G] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [apoe; le; c3; lw]
<Options>: A: apoe (bos taurus) (aka apolipoprotein e)
B: c3 (gallus gallus) (aka complement component 3)
C: c3g (drosophila melanogaster) (crossover suppressor on 3 of gowen (drosophila melanogaster)) (aka crossover suppressor on 3 of gowen)
D: les (homo sapiens) (aka fucosyltransferase ... | [E; D; I; S] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [lu; se; h; pepd]
<Options>: A: hl (homo sapiens) (aka lipase c, hepatic type)
B: selenon (homo sapiens) (aka selenoprotein n)
C: pepd (xenopus tropicalis) (aka peptidase d)
D: pepd (escherichia coli str. k-12 substr. mg1655) (aka peptidase d)
E: ht (homo sapiens) (aka hashimoto thyroiditis)
F: pepd (homo s... | [J; S; U; F] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [lu; se; h; pepd]
<Options>: A: hx (homo sapiens) (aka hemopexin)
B: sei1 (homo sapiens) (aka serta domain containing 1)
C: selenot (gallus gallus) (aka selenoprotein t)
D: se (homo sapiens) (aka fucosyltransferase 2 (h blood group))
E: selenos (gallus gallus) (aka selenoprotein s)
F: lulu (homo sapiens) (a... | [T; D; U; Q] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [lu; se; h; pepd]
<Options>: A: sef (homo sapiens) (aka interleukin 17 receptor d)
B: pepd (homo sapiens) (aka peptidase d)
C: pepd (xenopus laevis) (aka peptidase d l homeolog)
D: luth (bos taurus) (luteinizing hormone level (bos taurus)) (aka luteinizing hormone level)
E: selenot (gallus gallus) (aka sele... | [K; I; U; B] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [lu; se; h; pepd]
<Options>: A: lu1 (homo sapiens) (aka pdz domain containing 4)
B: selenos (gallus gallus) (aka selenoprotein s)
C: lu (homo sapiens) (aka basal cell adhesion molecule (lutheran blood group))
D: seh (homo sapiens) (aka epoxide hydrolase 2)
E: hhh (homo sapiens) (aka solute carrier family 25... | [C; S; U; J] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [myotonic dystrophy; dm; neurofibromatosis; nf]
<Options>: A: dm (homo sapiens) (aka dm1 protein kinase)
B: generalized neuroaxonal dystrophy (mus musculus) (aka generalized neuroaxonal dystrophy)
C: neurofibromin 1 (rattus norvegicus) (aka neurofibromin 1)
D: dystrophia myotonica-protein kinase (mus muscul... | [A; A; M; M] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [myotonic dystrophy; dm; neurofibromatosis; nf]
<Options>: A: nf-m (mus musculus) (neurofilament, medium polypeptide (mus musculus)) (aka neurofilament, medium polypeptide)
B: dm/dmyc (drosophila melanogaster) (aka myc)
C: dystrophin, muscular dystrophy (mus musculus) (aka dystrophin, muscular dystrophy)
D:... | [N; N; E; E] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [myotonic dystrophy; dm; neurofibromatosis; nf]
<Options>: A: nf (homo sapiens) (aka neurofascin)
B: myocd (mus musculus) (aka myocardin)
C: dm[[1]] (drosophila melanogaster) (aka lamin)
D: dmd (mus musculus) (aka dystrophin, muscular dystrophy)
E: dm (homo sapiens) (aka dm1 protein kinase)
F: nf-m (mus mus... | [E; E; P; P] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [myotonic dystrophy; dm; neurofibromatosis; nf]
<Options>: A: dm (homo sapiens) (aka dm1 protein kinase)
B: myocd (mus musculus) (aka myocardin)
C: neurofascin (mus musculus) (aka neurofascin)
D: nf1 (neurofibromin 1) promoter region (homo sapiens) (aka nf1 (neurofibromin 1) promoter region)
E: nf-m (mus mu... | [A; A; I; I] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [familial hypercholesterolemia; fhc]
<Options>: A: fh (homo sapiens) (complement factor h (homo sapiens)) (aka complement factor h)
B: fhca1 (homo sapiens) (aka tight junction protein 2)
C: ldlc (homo sapiens) (aka component of oligomeric golgi complex 2)
D: fh (gallus gallus) (aka fumarate hydratase)
E: fh... | [J; J] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [familial hypercholesterolemia; fhc]
<Options>: A: fhc (homo sapiens) (low density lipoprotein receptor (homo sapiens)) (aka low density lipoprotein receptor)
B: ldlc (homo sapiens) (aka component of oligomeric golgi complex 2)
C: fhdc1 (homo sapiens) (aka fh2 domain containing 1)
D: fhh (homo sapiens) (aka... | [A; A] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [lw; lewis blood group; le]
<Options>: A: gwl (bos taurus) (aka microtubule associated serine/threonine kinase like)
B: lipase, endothelial l homeolog (xenopus laevis) (aka lipase, endothelial l homeolog)
C: leo1 homolog, paf1/rna polymerase ii complex component s homeolog (xenopus laevis) (aka leo1 homolog... | [G; H; H] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [lw; lewis blood group; le]
<Options>: A: wd repeat-containing protein lwd2-like (glycine max) (aka wd repeat-containing protein lwd2-like)
B: lw-1 (homo sapiens) (aka heat shock transcription factor family, x-linked 1)
C: leo1 homolog, paf1/rna polymerase ii complex component (xenopus tropicalis) (aka leo1... | [K; F; F] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [lw; lewis blood group; le]
<Options>: A: lws (homo sapiens) (aka rna, u4atac small nuclear)
B: basal cell adhesion molecule (lutheran blood group) (homo sapiens) (aka basal cell adhesion molecule (lutheran blood group))
C: selectin l s homeolog (xenopus laevis) (aka selectin l s homeolog)
D: leb (homo sapi... | [G; K; K] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [le; c3; lw]
<Options>: A: c3 (homo sapiens) (aka complement c3)
B: apolipoprotein c3 (homo sapiens) (aka apolipoprotein c3)
C: lipase, endothelial l homeolog (xenopus laevis) (aka lipase, endothelial l homeolog)
D: lw (drosophila melanogaster) (aka long wing)
E: les (homo sapiens) (aka fucosyltransferase 3... | [E; A; G] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [le; c3; lw]
<Options>: A: le (mus musculus) (aka hps4, biogenesis of lysosomal organelles complex 3 subunit 2)
B: complement component 3 precursor pseudogene (homo sapiens) (aka complement component 3 precursor pseudogene)
C: leb (homo sapiens) (aka mucin 5ac, oligomeric mucus/gel-forming)
D: lw-1 (homo sa... | [L; M; E] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [le; c3; lw]
<Options>: A: wd repeat-containing protein lwd2-like (glycine max) (aka wd repeat-containing protein lwd2-like)
B: c3b (homo sapiens) (aka complement c3)
C: c3 (bos taurus) (aka complement c3)
D: lep (homo sapiens) (aka leptin)
E: le (mus musculus) (aka hps4, biogenesis of lysosomal organelles ... | [G; B; L] |
<Instruct>: Given the context 'Human beta-nerve growth factor gene sequence highly homologous to that of mouse.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta-nerve growth factor]
<Options>: A: brain-derived neurotrophic factor (rattus norvegicus) (aka brain-derived neurotrophic factor)
B: ngfb (rattus norvegicus) (aka nerve growth factor)
C: ngf (homo sapiens) (aka nerve growth factor)
D: brain derived neurotrophic factor (homo sapiens) (aka brain derived ... | [C] |
<Instruct>: Given the context 'Even so, beta-NGF comprises only approximately 0.1% of the protein in this small gland, which has made the study of this polypeptide difficult.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [beta-ngf]
<Options>: A: neurotrophin 6 beta (pseudogene) (homo sapiens) (aka neurotrophin 6 beta (pseudogene))
B: ngfb (rattus norvegicus) (aka nerve growth factor)
C: ngfb (bos taurus) (aka nerve growth factor)
D: beta-ngf (xenopus tropicalis) (aka nerve growth factor)
E: ngf (homo sapiens) (aka nerve gro... | [E] |
<Instruct>: Given the context 'The amino acid sequence of the mouse NGF beta-chain has been determined and some information has been obtained regarding the size of a mouse precursor molecule, pro-beta-NGF, but little was known about the structure and relatedness of beta-NGF from other vertebrates.', select the correct ... | <Mentions>: [ngf beta; beta-ngf]
<Options>: A: neuromedin b (rattus norvegicus) (aka neuromedin b)
B: ngfb (bos taurus) (aka nerve growth factor)
C: neurotrophin 6 beta (pseudogene) (homo sapiens) (aka neurotrophin 6 beta (pseudogene))
D: neuropeptide b (rattus norvegicus) (aka neuropeptide b)
E: beta-ngf (rattus norve... | [J; I] |
<Instruct>: Given the context 'The amino acid sequence of the mouse NGF beta-chain has been determined and some information has been obtained regarding the size of a mouse precursor molecule, pro-beta-NGF, but little was known about the structure and relatedness of beta-NGF from other vertebrates.', select the correct ... | <Mentions>: [ngf beta; beta-ngf]
<Options>: A: beta-ngf (rattus norvegicus) (aka nerve growth factor)
B: beta-ngf (homo sapiens) (aka nerve growth factor)
C: ngf (homo sapiens) (aka nerve growth factor)
D: ngfb (bos taurus) (aka nerve growth factor)
E: neurotrophin 6 beta (pseudogene) (homo sapiens) (aka neurotrophin 6... | [J; C] |
<Instruct>: Given the context 'Here we describe the isolation of mouse beta-NGF complementary DNA (cDNA) and present its nucleotide sequence, which predicts a prepro-beta-NGF molecule of Mr 27,000 (27K) and a pro-beta-NGF molecule of Mr 25K. We have used the mouse beta-NGF cDNA clone to isolate the human beta-NGF gene,... | <Mentions>: [beta-ngf]
<Options>: A: ngfb (bos taurus) (aka nerve growth factor)
B: ngfib (homo sapiens) (aka nuclear receptor subfamily 4 group a member 1)
C: brain derived neurotrophic factor (homo sapiens) (aka brain derived neurotrophic factor)
D: beta-ngf (homo sapiens) (aka nerve growth factor)
E: beta-ngf (xenop... | [F] |
<Instruct>: Given the context 'Here we describe the isolation of mouse beta-NGF complementary DNA (cDNA) and present its nucleotide sequence, which predicts a prepro-beta-NGF molecule of Mr 27,000 (27K) and a pro-beta-NGF molecule of Mr 25K. We have used the mouse beta-NGF cDNA clone to isolate the human beta-NGF gene,... | <Mentions>: [beta-ngf]
<Options>: A: beta-ngf (rattus norvegicus) (aka nerve growth factor)
B: ngfib (homo sapiens) (aka nuclear receptor subfamily 4 group a member 1)
C: brain derived neurotrophic factor (homo sapiens) (aka brain derived neurotrophic factor)
D: beta-ngf (homo sapiens) (aka nerve growth factor)
E: brai... | [D] |
<Instruct>: Given the context 'Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [alpha subunit of the rod cgmp-gated channel]
<Options>: A: cyclic nucleotide gated channel subunit alpha 1 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 1)
B: cgmp-gated cation channel alpha-1-like (rattus norvegicus) (aka cgmp-gated cation channel alpha-1-like)
C: protein kinase camp-d... | [F] |
<Instruct>: Given the context 'Mutations in the genes encoding two proteins of the retinal rod phototransduction cascade, opsin and the beta subunit of rod cGMP phosphodiesterase, cause retinitis pigmentosa (RP) in some families.', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [beta subunit of rod cgmp phosphodiesterase]
<Options>: A: phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide (mus musculus) (aka phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide)
B: gmp-pdebeta (homo sapiens) (aka phosphodiesterase 6b)
C: pde8b (homo sapiens) (aka phosphodiesterase 8b)
D:... | [B] |
<Instruct>: Given the context 'We screened 94 unrelated patients with autosomal dominant RP and 173 unrelated patients with autosomal recessive RP for mutations in the gene encoding the alpha subunit of the rod cGMP-gated cation channel.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [alpha subunit of the rod cgmp-gated cation channel]
<Options>: A: cgmp-gated cation channel alpha-1-like (rattus norvegicus) (aka cgmp-gated cation channel alpha-1-like)
B: cacna1a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
C: cyclic nucleotide gated channel subunit alpha 2 (homo s... | [F] |
<Instruct>: Given the context 'Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [cellular apoptosis susceptibility gene; cse1]
<Options>: A: cse (drosophila melanogaster) (chromosome segregation 1 (drosophila melanogaster)) (aka chromosome segregation 1)
B: cancer susceptibility 11 (homo sapiens) (aka cancer susceptibility 11)
C: cas (homo sapiens) (chromosome segregation 1 like (homo ... | [C; H] |
<Instruct>: Given the context 'Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [cellular apoptosis susceptibility gene; cse1]
<Options>: A: cse1l (homo sapiens) (aka chromosome segregation 1 like)
B: cse1 (saccharomyces cerevisiae s288c) (aka importin-alpha export receptor)
C: cancer susceptibility 11 (homo sapiens) (aka cancer susceptibility 11)
D: cse1 (escherichia coli str. k-12 su... | [F; B] |
<Instruct>: Given the context 'We report here that one of these fragments is an antisense fragment of a gene homologous to the essential yeast chromosome segregation gene CSE1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [cse1]
<Options>: A: cse1 (saccharomyces cerevisiae s288c) (aka importin-alpha export receptor)
B: cse1 chromosome segregation 1-like (xenopus tropicalis) (aka cse1 chromosome segregation 1-like)
C: cse1 (escherichia coli str. k-12 substr. mg1655) (aka type i-e crispr system cascade subunit casa)
D: csec (h... | [A] |
<Instruct>: Given the context 'Cloning and analysis of the full-length cDNA of the human CSE1 homologue, which we name CAS for cellular apoptosis susceptibility gene, reveals a protein coding region with similar length (971 amino acids for CAS, 960 amino acids for CSE1) and 59% overall protein homology to the yeast CSE... | <Mentions>: [cse1; cas; cellular apoptosis susceptibility gene]
<Options>: A: cse (drosophila melanogaster) (chromosome segregation 1 (drosophila melanogaster)) (aka chromosome segregation 1)
B: cuta divalent cation tolerance like (sus scrofa) (aka cuta divalent cation tolerance like)
C: cse1 (saccharomyces cerevisiae ... | [C; J; J] |
<Instruct>: Given the context 'Cloning and analysis of the full-length cDNA of the human CSE1 homologue, which we name CAS for cellular apoptosis susceptibility gene, reveals a protein coding region with similar length (971 amino acids for CAS, 960 amino acids for CSE1) and 59% overall protein homology to the yeast CSE... | <Mentions>: [cse1; cas; cellular apoptosis susceptibility gene]
<Options>: A: casa (homo sapiens) (aka casein alpha s1)
B: cuta divalent cation tolerance like (sus scrofa) (aka cuta divalent cation tolerance like)
C: cse1 chromosome segregation 1-like (xenopus tropicalis) (aka cse1 chromosome segregation 1-like)
D: can... | [M; N; N] |
<Instruct>: Given the context 'Cloning and analysis of the full-length cDNA of the human CSE1 homologue, which we name CAS for cellular apoptosis susceptibility gene, reveals a protein coding region with similar length (971 amino acids for CAS, 960 amino acids for CSE1) and 59% overall protein homology to the yeast CSE... | <Mentions>: [cse1; cas; cellular apoptosis susceptibility gene]
<Options>: A: cse (drosophila melanogaster) (chromosome segregation 1 (drosophila melanogaster)) (aka chromosome segregation 1)
B: cas3 (homo sapiens) (aka embryonal fyn-associated substrate)
C: csen (homo sapiens) (aka potassium voltage-gated channel inte... | [I; J; J] |
<Instruct>: Given the context 'Cloning and analysis of the full-length cDNA of the human CSE1 homologue, which we name CAS for cellular apoptosis susceptibility gene, reveals a protein coding region with similar length (971 amino acids for CAS, 960 amino acids for CSE1) and 59% overall protein homology to the yeast CSE... | <Mentions>: [cse1; cas; cellular apoptosis susceptibility gene]
<Options>: A: cas (homo sapiens) (chromosome segregation 1 like (homo sapiens)) (aka chromosome segregation 1 like)
B: cse1 chromosome segregation 1-like (xenopus tropicalis) (aka cse1 chromosome segregation 1-like)
C: cas3 (homo sapiens) (aka embryonal fy... | [F; A; A] |
<Instruct>: Given the context 'Cloning and analysis of the full-length cDNA of the human CSE1 homologue, which we name CAS for cellular apoptosis susceptibility gene, reveals a protein coding region with similar length (971 amino acids for CAS, 960 amino acids for CSE1) and 59% overall protein homology to the yeast CSE... | <Mentions>: [cse1]
<Options>: A: cse1 (saccharomyces cerevisiae s288c) (aka importin-alpha export receptor)
B: cse1 chromosome segregation 1-like (xenopus tropicalis) (aka cse1 chromosome segregation 1-like)
C: cse1 chromosome segregation 1-like s homeolog (xenopus laevis) (aka cse1 chromosome segregation 1-like s home... | [A] |
<Instruct>: Given the context 'The conservation of this gene indicates it has an important function in human cells consistent with the essential role of CSE1 in yeast.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [cse1]
<Options>: A: cse (drosophila melanogaster) (chromosome segregation 1 (drosophila melanogaster)) (aka chromosome segregation 1)
B: cse1 (saccharomyces cerevisiae s288c) (aka importin-alpha export receptor)
C: cse1 chromosome segregation 1-like s homeolog (xenopus laevis) (aka cse1 chromosome segregat... | [B] |
<Instruct>: Given the context 'CAS is highly expressed in human tumor cell lines and in human testis and fetal liver, tissues that contain actively dividing cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [cas]
<Options>: A: casa (homo sapiens) (aka casein alpha s1)
B: cas (homo sapiens) (bcar1 scaffold protein, cas family member (homo sapiens)) (aka bcar1 scaffold protein, cas family member)
C: cas1p (homo sapiens) (aka cas1 domain sialic acid o acetyltransferase 1)
D: cas (homo sapiens) (chromosome segrega... | [D] |
<Instruct>: Given the context 'Furthermore, CAS expression increases when resting human fibroblasts are induced to proliferate and decreases when they are growth-arrested.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [cas]
<Options>: A: cas (homo sapiens) (chromosome segregation 1 like (homo sapiens)) (aka chromosome segregation 1 like)
B: casr (homo sapiens) (aka calcium sensing receptor)
C: cas3 (homo sapiens) (aka embryonal fyn-associated substrate)
D: bcar1 scaffold protein, cas family member (gallus gallus) (aka bc... | [A] |
<Instruct>: Given the context 'Furthermore, CAS expression increases when resting human fibroblasts are induced to proliferate and decreases when they are growth-arrested.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [cas]
<Options>: A: bcar1 scaffold protein, cas family member (gallus gallus) (aka bcar1 scaffold protein, cas family member)
B: cas3 (homo sapiens) (aka embryonal fyn-associated substrate)
C: casr (homo sapiens) (aka calcium sensing receptor)
D: casa (homo sapiens) (aka casein alpha s1)
E: None of the abov... | [E] |
<Instruct>: Given the context 'Thus, CAS appears to play an important role in both toxin and tumor necrosis factor-mediated cell death, as well as in cell proliferation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [cas]
<Options>: A: bcar1 scaffold protein, cas family member (gallus gallus) (aka bcar1 scaffold protein, cas family member)
B: cas (homo sapiens) (chromosome segregation 1 like (homo sapiens)) (aka chromosome segregation 1 like)
C: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffo... | [B] |
<Instruct>: Given the context 'They were all located on the long arm of chromosome 17, in loci located between q11 and q21.3, a region known to contain the c-erbB-2 oncogene and the BRCA1 breast carcinomas, and overexpression of three of them was dependent on gene amplification in breast cancer cell lines.', select the... | <Mentions>: [c-erbb-2; brca1]
<Options>: A: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
B: brca1 (homo sapiens) (aka brca1 dna repair associated)
C: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka b... | [G; B] |
<Instruct>: Given the context 'They were all located on the long arm of chromosome 17, in loci located between q11 and q21.3, a region known to contain the c-erbB-2 oncogene and the BRCA1 breast carcinomas, and overexpression of three of them was dependent on gene amplification in breast cancer cell lines.', select the... | <Mentions>: [c-erbb-2; brca1]
<Options>: A: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
B: c-erbb3 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 3)
C: c-erb-2 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
D: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex me... | [C; G] |
<Instruct>: Given the context 'Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [striatum-enriched phosphatase; step]
<Options>: A: stp-1 (sus scrofa) (aka transition protein 1)
B: phosphoserine phosphatase (homo sapiens) (aka phosphoserine phosphatase)
C: try (sus scrofa) (aka serine protease 2)
D: o-sialoglycoprotein endopeptidase (sus scrofa) (aka o-sialoglycoprotein endopeptidase)
... | [F; F] |
<Instruct>: Given the context 'Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [striatum-enriched phosphatase; step]
<Options>: A: tptep (homo sapiens) (aka tpte2 pseudogene 4)
B: ctd small phosphatase like (sus scrofa) (aka ctd small phosphatase like)
C: ctd small phosphatase-like protein (sus scrofa) (aka ctd small phosphatase-like protein)
D: step1 (arabidopsis thaliana) (aka 31-kd... | [H; H] |
<Instruct>: Given the context 'By using a combination of somatic cell hybrid analysis and fluorescence in situ hybridization, we have mapped the human STEP locus to chromosome 11p15.2-p15.1 and the murine STEP gene to chromosome 7B3-B5.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [step]
<Options>: A: step (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 5)
B: tppp (sus scrofa) (aka tubulin polymerization promoting protein)
C: step (mus musculus) (aka protein tyrosine phosphatase, non-receptor type 5)
D: tptep (homo sapiens) (aka tpte2 pseudogene 4)
E: step (drosoph... | [A] |
<Instruct>: Given the context 'By using a combination of somatic cell hybrid analysis and fluorescence in situ hybridization, we have mapped the human STEP locus to chromosome 11p15.2-p15.1 and the murine STEP gene to chromosome 7B3-B5.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [step]
<Options>: A: step (mus musculus) (aka protein tyrosine phosphatase, non-receptor type 5)
B: tppp (sus scrofa) (aka tubulin polymerization promoting protein)
C: step (drosophila melanogaster) (aka steppke)
D: tptep (homo sapiens) (aka tpte2 pseudogene 4)
E: None of the above. | [E] |
<Instruct>: Given the context 'These are two regions of known conserved synteny, providing further evidence that the human STEP is a true homolog of the murine STEP gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [step]
<Options>: A: step (drosophila melanogaster) (aka steppke)
B: step (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 5)
C: stepp (homo sapiens) (aka peroxisomal testis enriched protein 1)
D: step1 (arabidopsis thaliana) (aka 31-kda rna binding protein)
E: try (sus scrofa) (aka serine... | [B] |
<Instruct>: Given the context 'Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [atp synthase oscp subunit; atp5o]
<Options>: A: atp5o (homo sapiens) (aka atp synthase peripheral stalk subunit oscp)
B: atp5i (homo sapiens) (aka atp synthase membrane subunit e)
C: atp synthase peripheral stalk subunit oscp (sus scrofa) (aka atp synthase peripheral stalk subunit oscp)
D: atp5j (homo sapi... | [A; A] |
<Instruct>: Given the context 'Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [atp synthase oscp subunit; atp5o]
<Options>: A: atp synthase peripheral stalk subunit oscp (xenopus tropicalis) (aka atp synthase peripheral stalk subunit oscp)
B: atp synthase subunit o, mitochondrial (caenorhabditis elegans) (aka atp synthase subunit o, mitochondrial)
C: atp synthase peripheral stalk sub... | [I; I] |
<Instruct>: Given the context 'We subsequently cloned the full-length human ATP synthase OSCP cDNA (GDB/HGMW approved name ATP50) from infant brain and muscle libraries and determined its nucleotide and deduced amino acid sequence (EMBL/GenBank Accession No. X83218).', select the correct biomedical concept for each men... | <Mentions>: [atp synthase oscp; atp50]
<Options>: A: atp5s (oryctolagus cuniculus) (aka distal membrane arm assembly component 2 like)
B: atp synthase peripheral stalk subunit oscp (homo sapiens) (aka atp synthase peripheral stalk subunit oscp)
C: atpa (escherichia coli str. k-12 substr. mg1655) (aka atp synthase f1 co... | [B; B] |
<Instruct>: Given the context 'We subsequently cloned the full-length human ATP synthase OSCP cDNA (GDB/HGMW approved name ATP50) from infant brain and muscle libraries and determined its nucleotide and deduced amino acid sequence (EMBL/GenBank Accession No. X83218).', select the correct biomedical concept for each men... | <Mentions>: [atp synthase oscp; atp50]
<Options>: A: atp synthase peripheral stalk subunit oscp (oryctolagus cuniculus) (aka atp synthase peripheral stalk subunit oscp)
B: atp5 (homo sapiens) (aka atp synthase peripheral stalk subunit f6)
C: atp synthase subunit o, mitochondrial (caenorhabditis elegans) (aka atp syntha... | [H; H] |
<Instruct>: Given the context 'The human ATP5O gene is located at 21q22.1-q22.2, just proximal to D21S17, in YACs 860G11 and 838C7 of the Chumakov et al.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [atp5o]
<Options>: A: atp5e (homo sapiens) (aka atp synthase f1 subunit epsilon)
B: atp5o (homo sapiens) (aka atp synthase peripheral stalk subunit oscp)
C: atp5h (homo sapiens) (aka atp synthase peripheral stalk subunit d)
D: atp5lp5 (homo sapiens) (aka atp synthase membrane subunit g pseudogene 5)
E: atp5... | [B] |
<Instruct>: Given the context 'The human ATP5O gene is located at 21q22.1-q22.2, just proximal to D21S17, in YACs 860G11 and 838C7 of the Chumakov et al.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [atp5o]
<Options>: A: atp5e (homo sapiens) (aka atp synthase f1 subunit epsilon)
B: atp5i (homo sapiens) (aka atp synthase membrane subunit e)
C: atp5h (homo sapiens) (aka atp synthase peripheral stalk subunit d)
D: atp5lp5 (homo sapiens) (aka atp synthase membrane subunit g pseudogene 5)
E: None of the abo... | [E] |
<Instruct>: Given the context 'This ATP5O subunit is a key structural component of the stalk of the mitochondrial respiratory chain F1F0-ATP synthase and as such may contribute in a gene dosage-dependent manner to the phenotype of Down syndrome (trisomy 21).', select the correct biomedical concept for each mention usin... | <Mentions>: [atp5o]
<Options>: A: atp5 (homo sapiens) (aka atp synthase peripheral stalk subunit f6)
B: atp5h (homo sapiens) (aka atp synthase peripheral stalk subunit d)
C: atp5o (mus musculus) (aka atp synthase peripheral stalk subunit oscp)
D: atp5i (homo sapiens) (aka atp synthase membrane subunit e)
E: atp5po (hom... | [E] |
<Instruct>: Given the context 'Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p.
Carbonic anhydrase V (CA V) is expressed in mitochondrial matrix in liver and several other tissues.', select the correct biomedical concep... | <Mentions>: [ca5; mitochondrial carbonic anhydrase v; carbonic anhydrase v; ca v]
<Options>: A: carbonic anhydrase vb, mitochondrial (xenopus tropicalis) (aka carbonic anhydrase vb, mitochondrial)
B: ca-vi (homo sapiens) (aka carbonic anhydrase 6)
C: carbonic anhydrase 7 (homo sapiens) (aka carbonic anhydrase 7)
D: car... | [E; E; E; E] |
<Instruct>: Given the context 'Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p.
Carbonic anhydrase V (CA V) is expressed in mitochondrial matrix in liver and several other tissues.', select the correct biomedical concep... | <Mentions>: [ca5; mitochondrial carbonic anhydrase v; carbonic anhydrase v; ca v]
<Options>: A: ca5 (gallus gallus) (aka carbonic anhydrase 5a)
B: carbonic anhydrase 5a (homo sapiens) (aka carbonic anhydrase 5a)
C: carbonic anhydrase 4 (homo sapiens) (aka carbonic anhydrase 4)
D: carbonic anhydrase 5b (homo sapiens) (a... | [B; B; B; B] |
<Instruct>: Given the context 'Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p.
Carbonic anhydrase V (CA V) is expressed in mitochondrial matrix in liver and several other tissues.', select the correct biomedical concep... | <Mentions>: [ca5; mitochondrial carbonic anhydrase v; carbonic anhydrase v; ca v]
<Options>: A: ca5d (homo sapiens) (aka carbonic anhydrase 5a)
B: carbonic anhydrase vii s homeolog (xenopus laevis) (aka carbonic anhydrase vii s homeolog)
C: carbonic anhydrase 5b (homo sapiens) (aka carbonic anhydrase 5b)
D: putative ca... | [A; A; A; A] |
<Instruct>: Given the context 'Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p.
Carbonic anhydrase V (CA V) is expressed in mitochondrial matrix in liver and several other tissues.', select the correct biomedical concep... | <Mentions>: [ca5; mitochondrial carbonic anhydrase v; carbonic anhydrase v; ca v]
<Options>: A: ca-vi (homo sapiens) (aka carbonic anhydrase 6)
B: ca-xiv (mus musculus) (aka carbonic anhydrase 14)
C: ca5 (gallus gallus) (aka carbonic anhydrase 5a)
D: putative carbonic anhydrase 5 (caenorhabditis elegans) (aka putative ... | [J; J; J; J] |
<Instruct>: Given the context 'It is of interest for its putative roles in providing bicarbonate to carbamoyl phosphate synthetase for ureagenesis and to pyruvate carboxylase for gluconeogenesis and its possible importance in explaining certain inherited metabolic disorders with hyperammonemia and hypoglycemia.', selec... | <Mentions>: [pyruvate carboxylase]
<Options>: A: pc (homo sapiens) (pyruvate carboxylase (homo sapiens)) (aka pyruvate carboxylase)
B: pyruvate carboxylase (sus scrofa) (aka pyruvate carboxylase)
C: pyruvate carboxylase (xenopus tropicalis) (aka pyruvate carboxylase)
D: pyruvate carboxylase 1 (saccharomyces cerevisiae ... | [A] |
<Instruct>: Given the context 'Following the recent characterization of the cDNA for human CA V, we report the isolation of the human gene from two lambda genomic libraries and its characterization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [ca v]
<Options>: A: ca5a (homo sapiens) (aka carbonic anhydrase 5a)
B: ca5p (homo sapiens) (aka carbonic anhydrase 5a pseudogene 1)
C: ca-vi (homo sapiens) (aka carbonic anhydrase 6)
D: carbonic anhydrase 5b (homo sapiens) (aka carbonic anhydrase 5b)
E: ca5b (xenopus laevis) (aka carbonic anhydrase vb, mit... | [A] |
<Instruct>: Given the context 'The CA V gene (CA5) is approximately 50 kb long and contains 7 exons and 6 introns.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ca v; ca5]
<Options>: A: ca-vi (homo sapiens) (aka carbonic anhydrase 6)
B: ca5 (gallus gallus) (aka carbonic anhydrase 5a)
C: putative carbonic anhydrase 5 (caenorhabditis elegans) (aka putative carbonic anhydrase 5)
D: ca5a (homo sapiens) (aka carbonic anhydrase 5a)
E: carbonic anhydrase 5b (homo sapiens... | [D; D] |
<Instruct>: Given the context 'The CA V gene (CA5) is approximately 50 kb long and contains 7 exons and 6 introns.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ca v; ca5]
<Options>: A: ca5b (homo sapiens) (aka carbonic anhydrase 5b)
B: ca5p (homo sapiens) (aka carbonic anhydrase 5a pseudogene 1)
C: carbonic anhydrase 5a (homo sapiens) (aka carbonic anhydrase 5a)
D: ca5b (xenopus laevis) (aka carbonic anhydrase vb, mitochondrial l homeolog)
E: ca5 (gallus gallus) ... | [C; C] |
<Instruct>: Given the context 'The exon-intron boundaries are found in positions identical to those determined for the previously described CA II, CA III, and CA VII genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [ca ii; ca iii; ca vii]
<Options>: A: carbonic anhydrase i (xenopus tropicalis) (aka carbonic anhydrase i)
B: carbonic anhydrase 2 (homo sapiens) (aka carbonic anhydrase 2)
C: ca-rp ii (homo sapiens) (aka carbonic anhydrase 11)
D: carbonic anhydrase vii s homeolog (xenopus laevis) (aka carbonic anhydrase vi... | [B; E; M] |
<Instruct>: Given the context 'The exon-intron boundaries are found in positions identical to those determined for the previously described CA II, CA III, and CA VII genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [ca ii; ca iii; ca vii]
<Options>: A: carbonic anhydrase vii s homeolog (xenopus laevis) (aka carbonic anhydrase vii s homeolog)
B: caxiii (homo sapiens) (aka carbonic anhydrase 13)
C: caiii (homo sapiens) (aka carbonic anhydrase 3)
D: ca-vi (homo sapiens) (aka carbonic anhydrase 6)
E: ca-i (homo sapiens) (... | [F; K; J] |
<Instruct>: Given the context 'The exon-intron boundaries are found in positions identical to those determined for the previously described CA II, CA III, and CA VII genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [ca ii; ca iii; ca vii]
<Options>: A: cai2 (homo sapiens) (aka cyclin dependent kinase inhibitor 2a)
B: ca-ii (homo sapiens) (aka carbonic anhydrase 2)
C: carbonic anhydrase 3a (gallus gallus) (aka carbonic anhydrase 3a)
D: carbonic anhydrase 3 (homo sapiens) (aka carbonic anhydrase 3)
E: ca-viii (homo sapi... | [B; D; L] |
<Instruct>: Given the context 'Like the CA VII gene, CA5 does not contain typical TATA and CAAT promoter elements in the 5' flanking region but does contain a TTTAA sequence 147 nucleotides upstream of the initiation codon.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [ca vii; ca5]
<Options>: A: carbonic anhydrase vii (xenopus tropicalis) (aka carbonic anhydrase vii)
B: ca5 (gallus gallus) (aka carbonic anhydrase 5a)
C: ca-vi (homo sapiens) (aka carbonic anhydrase 6)
D: ca7.5 (mus musculus) (aka dna segment, ca7.5)
E: carbonic anhydrase vii s homeolog (xenopus laevis) (a... | [G; I] |
<Instruct>: Given the context 'Like the CA VII gene, CA5 does not contain typical TATA and CAAT promoter elements in the 5' flanking region but does contain a TTTAA sequence 147 nucleotides upstream of the initiation codon.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [ca vii; ca5]
<Options>: A: ca-vi (homo sapiens) (aka carbonic anhydrase 6)
B: ca7 (xenopus tropicalis) (aka carbonic anhydrase vii)
C: putative carbonic anhydrase 5 (caenorhabditis elegans) (aka putative carbonic anhydrase 5)
D: ca7 (gallus gallus) (aka carbonic anhydrase 7)
E: ca5p (homo sapiens) (aka car... | [I; J] |
<Instruct>: Given the context 'CA5 also contains a 12-bp GT-rich segment beginning 13 bp downstream of the polyadenylation signal in the 3' untranslated region of exon 7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [ca5]
<Options>: A: ca5p (homo sapiens) (aka carbonic anhydrase 5a pseudogene 1)
B: putative carbonic anhydrase 5 (caenorhabditis elegans) (aka putative carbonic anhydrase 5)
C: ca5 (gallus gallus) (aka carbonic anhydrase 5a)
D: carbonic anhydrase 5a (homo sapiens) (aka carbonic anhydrase 5a)
E: ca-vi (homo... | [D] |
<Instruct>: Given the context 'FISH analysis allowed CA5 to be assigned to chromosome 16q24.3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ca5]
<Options>: A: carbonic anhydrase 5b (homo sapiens) (aka carbonic anhydrase 5b)
B: ca5p (homo sapiens) (aka carbonic anhydrase 5a pseudogene 1)
C: ca5a (homo sapiens) (aka carbonic anhydrase 5a)
D: putative carbonic anhydrase 5 (caenorhabditis elegans) (aka putative carbonic anhydrase 5)
E: ca5 (gallus... | [C] |
<Instruct>: Given the context 'Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca1]
<Options>: A: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
B: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
C: brca1 pseudogene 1 (homo sapiens) (aka brca1 pseudogene 1)
D: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
E: b... | [E] |
<Instruct>: Given the context 'Fragments corresponding to the broadly expressed gamma-tubulin and Ki antigen genes were identified.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ki antigen]
<Options>: A: kia (xenopus laevis) (marker of proliferation ki-67 s homeolog (xenopus laevis)) (aka marker of proliferation ki-67 s homeolog)
B: antigen identified by monoclonal antibody ki 67 (mus musculus) (aka antigen identified by monoclonal antibody ki 67)
C: ki (homo sapiens) (aka proteas... | [C] |
<Instruct>: Given the context 'Fragments corresponding to the broadly expressed gamma-tubulin and Ki antigen genes were identified.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ki antigen]
<Options>: A: kia (xenopus laevis) (marker of proliferation ki-67 s homeolog (xenopus laevis)) (aka marker of proliferation ki-67 s homeolog)
B: antigen identified by monoclonal antibody ki 67 (mus musculus) (aka antigen identified by monoclonal antibody ki 67)
C: marker of proliferation ki-67 ... | [E] |
<Instruct>: Given the context 'A full-length cDNA clone encoding a 117-amino-acid protein homologous to the rat ribosomal protein L34 was isolated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ribosomal protein l34]
<Options>: A: ribosomal protein l34 (gallus gallus) (aka ribosomal protein l34)
B: ribosomal protein l34 (xenopus tropicalis) (aka ribosomal protein l34)
C: ribosomal protein l34 (bos taurus) (aka ribosomal protein l34)
D: mitochondrial ribosomal protein l34 (homo sapiens) (aka mitoc... | [F] |
<Instruct>: Given the context 'Portions of genes with restricted patterns of expression were also obtained, including the previously characterized HSD17B1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [hsd17b1]
<Options>: A: hsd17b3 (homo sapiens) (aka hydroxysteroid 17-beta dehydrogenase 3)
B: hsd17b1 promoter (homo sapiens) (aka hsd17b1 promoter)
C: hsd17b2 (homo sapiens) (aka hydroxysteroid 17-beta dehydrogenase 2)
D: hsd11b1 (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
E: hsd17b1 (homo... | [E] |
<Instruct>: Given the context 'A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hkv beta 1.3]
<Options>: A: kv-beta-3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 3)
B: hkvb3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
C: hkvbeta2 (homo sapiens) (aka potassium voltage-gated channel subfamily a re... | [B] |
<Instruct>: Given the context 'We report here a novel K+ channel beta-subunit cloned from human heart, hKv beta 1.3, that has 74-83% overall identity with previously cloned beta-subunits.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [hkv beta 1.3]
<Options>: A: kv-beta-1 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
B: kvbeta1.3 (xenopus tropicalis) (aka potassium channel, voltage gated subfamily a regulatory beta subunit 1)
C: hkvbeta2.2 (homo sapiens) (aka potassium voltage-gated channel s... | [A] |
<Instruct>: Given the context 'Comparison of hKv beta 1.3 with the previously cloned hKv beta 3 and rKv beta 1 proteins indicates that the carboxyl-terminal 328 amino acids are identical, while unique variable length amino termini exist.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [hkv beta 1.3; hkv beta 3; rkv beta 1]
<Options>: A: k(vca)beta-3 (homo sapiens) (aka potassium calcium-activated channel subfamily m regulatory beta subunit 3)
B: kv-beta-3 (xenopus tropicalis) (aka potassium channel, voltage gated subfamily a regulatory beta subunit 3)
C: kv-beta-2 (homo sapiens) (aka pot... | [J; K; D] |
<Instruct>: Given the context 'Comparison of hKv beta 1.3 with the previously cloned hKv beta 3 and rKv beta 1 proteins indicates that the carboxyl-terminal 328 amino acids are identical, while unique variable length amino termini exist.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [hkv beta 1.3; hkv beta 3; rkv beta 1]
<Options>: A: potassium voltage-gated channel subfamily a regulatory beta subunit 1 (rattus norvegicus) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
B: kvbeta1.3 (xenopus tropicalis) (aka potassium channel, voltage gated subfamily a regul... | [D; L; A] |
<Instruct>: Given the context 'Comparison of hKv beta 1.3 with the previously cloned hKv beta 3 and rKv beta 1 proteins indicates that the carboxyl-terminal 328 amino acids are identical, while unique variable length amino termini exist.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [hkv beta 1.3; hkv beta 3; rkv beta 1]
<Options>: A: kv-beta-3 (xenopus tropicalis) (aka potassium channel, voltage gated subfamily a regulatory beta subunit 3)
B: slo-beta-3 (homo sapiens) (aka potassium calcium-activated channel subfamily m regulatory beta subunit 3)
C: potassium voltage-gated channel sub... | [M; H; C] |
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