instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; il-10; il-17; ifn-gamma]
<Options>: A: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
B: interferon gamma (homo sapiens) (aka interferon gamma)
C: il17 (homo sapiens) (aka interleukin 17a)
D: il-10 (oryctolagus cuniculus) (aka interleukin 10)
E: il-10c (homo sapiens) (aka interleukin 19)
F: interleukin 5 (homo sapiens) (aka interleukin 5)
G: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
H: interleukin 10 (homo sapiens) (aka interleukin 10)
I: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
J: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
K: il-4 (homo sapiens) (aka interleukin 4)
L: il-4 (bos taurus) (aka interleukin 4)
M: interleukin 17c (homo sapiens) (aka interleukin 17c)
N: il-17f (homo sapiens) (aka interleukin 17f)
O: il-17 (bos taurus) (aka interleukin 17a)
P: cd3-gammaamma (homo sapiens) (aka cd3 gamma subunit of t-cell receptor complex)
Q: interferon gamma (sus scrofa) (aka interferon gamma)
R: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
S: interferon gamma (mus musculus) (aka interferon gamma)
T: None of the above. | [K; H; C; B] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: i-tac (mus musculus) (aka chemokine (c-x-c motif) ligand 11)
B: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
D: ifn-alphaa (homo sapiens) (aka interferon alpha 2)
E: ik cytokine (homo sapiens) (aka ik cytokine)
F: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
G: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
H: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
I: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
J: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
K: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
L: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
M: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
N: gip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
O: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
P: il-10c (homo sapiens) (aka interleukin 19)
Q: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
R: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
S: tnfc (homo sapiens) (aka lymphotoxin beta)
T: tac1 (homo sapiens) (aka tachykinin precursor 1)
U: None of the above. | [O; N; H; K] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
B: tnfc (homo sapiens) (aka lymphotoxin beta)
C: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
D: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
E: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
F: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
G: c-x-c motif chemokine ligand 10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
H: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
I: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
J: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
K: ifn-alphaa (homo sapiens) (aka interferon alpha 2)
L: interleukin 10 (homo sapiens) (aka interleukin 10)
M: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
N: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
O: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
P: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
Q: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
R: tac1 (homo sapiens) (aka tachykinin precursor 1)
S: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
T: tnf-a (xenopus tropicalis) (aka tumor necrosis factor)
U: None of the above. | [H; G; P; M] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
B: tnfc (homo sapiens) (aka lymphotoxin beta)
C: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
D: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
E: tnf-a (xenopus tropicalis) (aka tumor necrosis factor)
F: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
G: gip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
H: il-10a (homo sapiens) (aka interleukin 10)
I: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
J: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
K: ifn-alpha (homo sapiens) (aka interferon alpha 1)
L: taci (homo sapiens) (aka tnf receptor superfamily member 13b)
M: ik cytokine (homo sapiens) (aka ik cytokine)
N: il-10c (homo sapiens) (aka interleukin 19)
O: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
P: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
Q: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
R: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
S: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
T: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
U: None of the above. | [I; G; Q; T] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
B: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
C: ifn-alpha (homo sapiens) (aka interferon alpha 1)
D: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
E: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
F: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
G: taci (homo sapiens) (aka tnf receptor superfamily member 13b)
H: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
I: tnfa (homo sapiens) (aka tumor necrosis factor)
J: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
K: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
L: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
M: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
N: il-10c (homo sapiens) (aka interleukin 19)
O: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
P: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
Q: tnf-a (xenopus tropicalis) (aka tumor necrosis factor)
R: il-10a (homo sapiens) (aka interleukin 10)
S: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
T: None of the above. | [I; H; P; E] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ip-10; mig]
<Options>: A: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
B: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
D: mig9 (homo sapiens) (aka s100 calcium binding protein p)
E: il-10c (homo sapiens) (aka interleukin 19)
F: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
G: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
H: il-10a (homo sapiens) (aka interleukin 10)
I: gip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
J: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
K: None of the above. | [I; A] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ip-10; mig]
<Options>: A: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
B: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
C: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
D: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
E: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
F: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
G: interleukin 10 (homo sapiens) (aka interleukin 10)
H: il-10c (homo sapiens) (aka interleukin 19)
I: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
J: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
K: None of the above. | [C; A] |
<Instruct>: Given the context 'Immunohistochemistry of skin affected by ACD revealed that >70% of infiltrating cells were reactive for CXCR3 and that CXCR3 staining colocalized in CD4+ and CD8+ T cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr3]
<Options>: A: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
B: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
C: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
D: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
F: None of the above. | [D] |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifn-gamma; il-4; cxcr3]
<Options>: A: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
B: interleukin 5 (homo sapiens) (aka interleukin 5)
C: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
D: il-4 (homo sapiens) (aka interleukin 4)
E: il-4 (bos taurus) (aka interleukin 4)
F: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
G: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
H: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
I: interferon gamma (sus scrofa) (aka interferon gamma)
J: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
K: interferon gamma (homo sapiens) (aka interferon gamma)
L: interferon gamma (mus musculus) (aka interferon gamma)
M: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
N: ifn-gamma (gallus gallus) (aka interferon)
O: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
P: None of the above. | [K; D; F] |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifn-gamma; il-4; cxcr3]
<Options>: A: interferon gamma (mus musculus) (aka interferon gamma)
B: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
C: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
D: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
E: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
F: cd3-gammaamma (homo sapiens) (aka cd3 gamma subunit of t-cell receptor complex)
G: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
H: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
I: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
J: il4 (homo sapiens) (aka interleukin 4)
K: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
L: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
M: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
N: interleukin 5 (homo sapiens) (aka interleukin 5)
O: interferon gamma (homo sapiens) (aka interferon gamma)
P: None of the above. | [O; J; H] |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifn-gamma; il-4; cxcr3]
<Options>: A: cd3-gammaamma (homo sapiens) (aka cd3 gamma subunit of t-cell receptor complex)
B: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma)
C: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
D: il-4 (homo sapiens) (aka interleukin 4)
E: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
F: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
G: il-4 (bos taurus) (aka interleukin 4)
H: interferon gamma (mus musculus) (aka interferon gamma)
I: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
J: interferon gamma (homo sapiens) (aka interferon gamma)
K: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
L: interferon gamma (sus scrofa) (aka interferon gamma)
M: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
N: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
O: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
P: None of the above. | [J; D; N] |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr3; ifn-gamma; il-4]
<Options>: A: interferon gamma (gallus gallus) (aka interferon gamma)
B: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
C: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
D: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
E: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
F: il-4 (homo sapiens) (aka interleukin 4)
G: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
H: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
I: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
J: interferon gamma (mus musculus) (aka interferon gamma)
K: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
L: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
M: interferon gamma (homo sapiens) (aka interferon gamma)
N: il4 (bos taurus) (aka interleukin 4)
O: interleukin 5 (homo sapiens) (aka interleukin 5)
P: None of the above. | [G; M; F] |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr3; ifn-gamma; il-4]
<Options>: A: interferon gamma (homo sapiens) (aka interferon gamma)
B: interferon gamma (sus scrofa) (aka interferon gamma)
C: interleukin 5 (homo sapiens) (aka interleukin 5)
D: il-4 (homo sapiens) (aka interleukin 4)
E: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
F: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
G: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
H: interferon gamma (xenopus tropicalis) (aka interferon gamma)
I: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
J: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
K: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
L: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
M: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
N: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
O: interferon gamma (gallus gallus) (aka interferon gamma)
P: None of the above. | [N; A; D] |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr3; ifn-gamma; il-4]
<Options>: A: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
B: interleukin 4 (homo sapiens) (aka interleukin 4)
C: cd3-gammaamma (homo sapiens) (aka cd3 gamma subunit of t-cell receptor complex)
D: interferon gamma (homo sapiens) (aka interferon gamma)
E: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
F: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
G: interleukin 5 (homo sapiens) (aka interleukin 5)
H: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
I: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
J: interferon gamma (mus musculus) (aka interferon gamma)
K: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
L: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
M: ifn-gamma (gallus gallus) (aka interferon)
N: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
O: interleukin 4 (bos taurus) (aka interleukin 4)
P: None of the above. | [L; D; B] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: tnfc (homo sapiens) (aka lymphotoxin beta)
B: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
C: interleukin 5 (homo sapiens) (aka interleukin 5)
D: ifi10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
E: il-10c (homo sapiens) (aka interleukin 19)
F: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
G: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
H: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
I: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
J: interferon gamma (xenopus tropicalis) (aka interferon gamma)
K: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
L: ifn-alpha (homo sapiens) (aka interferon alpha 1)
M: interferon gamma (gallus gallus) (aka interferon gamma)
N: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
O: tnfa (homo sapiens) (aka tumor necrosis factor)
P: il-10a (homo sapiens) (aka interleukin 10)
Q: tnf-a (xenopus tropicalis) (aka tumor necrosis factor)
R: interferon gamma (homo sapiens) (aka interferon gamma)
S: interleukin 4 (homo sapiens) (aka interleukin 4)
T: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
U: None of the above. | [S; R; O; D] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
B: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
C: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
D: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
E: interferon gamma (sus scrofa) (aka interferon gamma)
F: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
G: interferon gamma (gallus gallus) (aka interferon gamma)
H: il-10c (homo sapiens) (aka interleukin 19)
I: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
J: il-10a (homo sapiens) (aka interleukin 10)
K: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
L: gip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
M: interferon gamma (homo sapiens) (aka interferon gamma)
N: cd3-gammaamma (homo sapiens) (aka cd3 gamma subunit of t-cell receptor complex)
O: il-4 (homo sapiens) (aka interleukin 4)
P: il4 (bos taurus) (aka interleukin 4)
Q: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
R: ifn-gamma (gallus gallus) (aka interferon)
S: tnfc (homo sapiens) (aka lymphotoxin beta)
T: ifn-alpha (homo sapiens) (aka interferon alpha 1)
U: None of the above. | [O; M; Q; L] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
B: tnf (homo sapiens) (aka tumor necrosis factor)
C: il-10c (homo sapiens) (aka interleukin 19)
D: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
E: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
F: interleukin 4 (homo sapiens) (aka interleukin 4)
G: interferon gamma (sus scrofa) (aka interferon gamma)
H: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma)
I: tnfc (homo sapiens) (aka lymphotoxin beta)
J: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
K: interleukin 5 (homo sapiens) (aka interleukin 5)
L: ifn-alpha (homo sapiens) (aka interferon alpha 1)
M: ifn-alphaa (homo sapiens) (aka interferon alpha 2)
N: interferon gamma (xenopus tropicalis) (aka interferon gamma)
O: il-10a (homo sapiens) (aka interleukin 10)
P: interferon gamma (homo sapiens) (aka interferon gamma)
Q: gip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
R: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
S: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
T: cd3-gammaamma (homo sapiens) (aka cd3 gamma subunit of t-cell receptor complex)
U: None of the above. | [F; P; B; Q] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
B: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
C: interferon gamma (homo sapiens) (aka interferon gamma)
D: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
E: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
F: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
G: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
H: il4 (homo sapiens) (aka interleukin 4)
I: ifn-alphaa (homo sapiens) (aka interferon alpha 2)
J: il-10c (homo sapiens) (aka interleukin 19)
K: tnfc (homo sapiens) (aka lymphotoxin beta)
L: tnf (homo sapiens) (aka tumor necrosis factor)
M: c-x-c motif chemokine ligand 10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
N: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
O: interferon gamma (sus scrofa) (aka interferon gamma)
P: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
Q: ifn-gamma (gallus gallus) (aka interferon)
R: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma)
S: interleukin 4 (bos taurus) (aka interleukin 4)
T: interferon gamma (xenopus tropicalis) (aka interferon gamma)
U: None of the above. | [H; C; L; M] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
B: c-x-c motif chemokine ligand 10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: ifn-gamma (gallus gallus) (aka interferon)
D: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
E: interferon gamma (sus scrofa) (aka interferon gamma)
F: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
G: interleukin 4 (bos taurus) (aka interleukin 4)
H: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
I: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
J: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
K: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
L: tnfc (homo sapiens) (aka lymphotoxin beta)
M: interferon gamma (homo sapiens) (aka interferon gamma)
N: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
O: ifn-alphaa (homo sapiens) (aka interferon alpha 2)
P: il4 (homo sapiens) (aka interleukin 4)
Q: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma)
R: interferon gamma (xenopus tropicalis) (aka interferon gamma)
S: il-10c (homo sapiens) (aka interleukin 19)
T: None of the above. | [P; M; T; B] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
B: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
C: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
D: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
E: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
F: i-tac (mus musculus) (aka chemokine (c-x-c motif) ligand 11)
G: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
H: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
I: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
J: tac1 (homo sapiens) (aka tachykinin precursor 1)
K: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
L: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
M: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
N: ik cytokine (homo sapiens) (aka ik cytokine)
O: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
P: None of the above. | [K; D; G] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
B: tac1 (homo sapiens) (aka tachykinin precursor 1)
C: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
D: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
E: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
F: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
G: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
H: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
I: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
J: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
K: taci (homo sapiens) (aka tnf receptor superfamily member 13b)
L: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
M: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
N: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
O: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
P: None of the above. | [G; I; F] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
B: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
C: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
D: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
E: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
F: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
G: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
H: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
I: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
J: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
K: mig9 (homo sapiens) (aka s100 calcium binding protein p)
L: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
M: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
N: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
O: ik cytokine (homo sapiens) (aka ik cytokine)
P: None of the above. | [G; N; J] |
<Instruct>: Given the context 'The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf; mll]
<Options>: A: mll (homo sapiens) (aka lysine methyltransferase 2a)
B: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
C: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
D: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
E: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
F: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
G: mllt2-like (homo sapiens) (aka alf transcription elongation factor 3)
H: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
I: graf (homo sapiens) (aka rho gtpase activating protein 26)
J: mllt1 super elongation complex subunit (homo sapiens) (aka mllt1 super elongation complex subunit)
K: None of the above. | [I; A] |
<Instruct>: Given the context 'The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf; mll]
<Options>: A: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
B: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
C: grap (homo sapiens) (aka grb2 related adaptor protein)
D: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
E: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
F: mllt7 (homo sapiens) (aka forkhead box o4)
G: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
H: mllt2-like (homo sapiens) (aka alf transcription elongation factor 3)
I: mll1 (homo sapiens) (aka lysine methyltransferase 2a)
J: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
K: None of the above. | [D; I] |
<Instruct>: Given the context 'We have isolated the human GRAF gene (for GTPase regulator associated with the focal adhesion kinase pp125(FAK)).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
B: grap (homo sapiens) (aka grb2 related adaptor protein)
C: graf (homo sapiens) (aka rho gtpase activating protein 26)
D: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
E: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'This gene was fused with MLL in a unique t(5;11)(q31;q23) that occurred in an infant with juvenile myelomonocytic leukemia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mll]
<Options>: A: mllt7 (homo sapiens) (aka forkhead box o4)
B: mll1 (homo sapiens) (aka lysine methyltransferase 2a)
C: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
D: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
E: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11)
F: None of the above. | [B] |
<Instruct>: Given the context 'GRAF encodes a member of the Rho family of the GTPase-activating protein (GAP) family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf (homo sapiens) (aka rho gtpase activating protein 26)
B: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
C: graf (xenopus tropicalis) (aka rho gtpase activating protein 26)
D: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
E: grap (homo sapiens) (aka grb2 related adaptor protein)
F: None of the above. | [A] |
<Instruct>: Given the context 'On the protein level, it is 90% homologous to the recently described chicken GRAF gene that functions as a GAP of RhoA in vivo and is thus a critical component of the integrin signaling transduction pathway.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf; rhoa]
<Options>: A: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
B: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
C: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
D: rhoa-a (xenopus laevis) (ras homolog family member a l homeolog (xenopus laevis)) (aka ras homolog family member a l homeolog)
E: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
F: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
G: rho family gtpase 1 (homo sapiens) (aka rho family gtpase 1)
H: arha (homo sapiens) (aka ras homolog family member a)
I: ras homolog family member a (xenopus tropicalis) (aka ras homolog family member a)
J: rhoa-a (xenopus laevis) (ras homolog family member a s homeolog (xenopus laevis)) (aka ras homolog family member a s homeolog)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'On the protein level, it is 90% homologous to the recently described chicken GRAF gene that functions as a GAP of RhoA in vivo and is thus a critical component of the integrin signaling transduction pathway.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf; rhoa]
<Options>: A: rho (drosophila melanogaster) (rho1 (drosophila melanogaster)) (aka rho1)
B: graf (homo sapiens) (aka rho gtpase activating protein 26)
C: ras homolog family member a (xenopus tropicalis) (aka ras homolog family member a)
D: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
E: rhoa-a (xenopus laevis) (ras homolog gene family, member a, gene 2 s homeolog (xenopus laevis)) (aka ras homolog gene family, member a, gene 2 s homeolog)
F: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
G: graf1 (xenopus tropicalis) (aka rho gtpase activating protein 26)
H: rhoa-a (xenopus laevis) (ras homolog family member a l homeolog (xenopus laevis)) (aka ras homolog family member a l homeolog)
I: grap (homo sapiens) (aka grb2 related adaptor protein)
J: rhoa (homo sapiens) (aka ras homolog family member a)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'The particular position of the human GRAF gene at 5q31 and the proposed antiproliferative and tumor suppressor properties of its avian homologue suggest that it also might be pathogenetically relevant for hematologic malignancies with deletions of 5q.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
B: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
C: grap (homo sapiens) (aka grb2 related adaptor protein)
D: graf (homo sapiens) (aka rho gtpase activating protein 26)
E: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'To investigate this possibility, we sequenced 4-5 individual cDNA clones from 13 cases in which one allele of GRAF was deleted.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
B: graf (homo sapiens) (aka rho gtpase activating protein 26)
C: grap (homo sapiens) (aka grb2 related adaptor protein)
D: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
E: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'We found point mutations within the GAP domain of the second GRAF allele in one patient.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: grap (homo sapiens) (aka grb2 related adaptor protein)
B: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
C: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
D: graf1 (xenopus tropicalis) (aka rho gtpase activating protein 26)
E: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'In two additional patients we found an insertion of 52 or 74 bp within the GRAF cDNA that generates a reading frame shift followed by a premature stop codon.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
B: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
C: grap (homo sapiens) (aka grb2 related adaptor protein)
D: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
E: graf (xenopus tropicalis) (aka rho gtpase activating protein 26)
F: None of the above. | [B] |
<Instruct>: Given the context 'GRAF maps outside the previously defined commonly deleted 5q31 region.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf1 (xenopus tropicalis) (aka rho gtpase activating protein 26)
B: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
C: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
D: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
E: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
F: None of the above. | [E] |
<Instruct>: Given the context 'Nevertheless, inactivation of both alleles in at least some cases suggests that deletions and mutations of the GRAF gene may be instrumental in the development and progression of hematopoeitic disorders with a del(5q).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
B: graf (xenopus tropicalis) (aka rho gtpase activating protein 26)
C: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
D: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
E: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
F: None of the above. | [A] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
B: c-c motif chemokine ligand 26 (homo sapiens) (aka c-c motif chemokine ligand 26)
C: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
D: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
E: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
F: cc-ckr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
G: c-c motif chemokine ligand 3 (homo sapiens) (aka c-c motif chemokine ligand 3)
H: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
I: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
J: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
K: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
L: ckr-1 (homo sapiens) (c-c motif chemokine receptor 1 (homo sapiens)) (aka c-c motif chemokine receptor 1)
M: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
N: ckr-1 (homo sapiens) (c-x-c motif chemokine receptor 1 (homo sapiens)) (aka c-x-c motif chemokine receptor 1)
O: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
P: c-x-c motif chemokine ligand 13 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
Q: cc-ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
R: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
S: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
T: None of the above. | [E; L; F; E] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
B: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
C: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
D: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
E: c-x-c motif chemokine ligand 13 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
F: cc-ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
G: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
H: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
I: c-c motif chemokine ligand 26 (homo sapiens) (aka c-c motif chemokine ligand 26)
J: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
K: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
L: ckr-1 (homo sapiens) (c-c motif chemokine receptor 1 (homo sapiens)) (aka c-c motif chemokine receptor 1)
M: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
N: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
O: c-c motif chemokine ligand 3 (homo sapiens) (aka c-c motif chemokine ligand 3)
P: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
Q: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
R: ckr-1 (homo sapiens) (c-x-c motif chemokine receptor 1 (homo sapiens)) (aka c-x-c motif chemokine receptor 1)
S: None of the above. | [G; L; S; G] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
B: cc-ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
C: lec1 (drosophila melanogaster) (aka parched)
D: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
E: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
F: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
G: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
H: lce (homo sapiens) (aka elovl fatty acid elongase 6)
I: cmkbr8 (homo sapiens) (aka c-c motif chemokine receptor 8)
J: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
K: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
L: c-c motif chemokine 21-like (xenopus tropicalis) (aka c-c motif chemokine 21-like)
M: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
N: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
O: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
P: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
Q: c-c-ckr-1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
R: ccr1 (homo sapiens) (aka c-c motif chemokine receptor 1)
S: c-x-c motif chemokine ligand 13 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
T: None of the above. | [P; R; I; P] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
B: c-c motif chemokine 21-like (xenopus tropicalis) (aka c-c motif chemokine 21-like)
C: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
D: ccr1 (homo sapiens) (aka c-c motif chemokine receptor 1)
E: lec1 (homo sapiens) (aka adhesion g protein-coupled receptor l2)
F: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
G: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
H: ckr-1 (homo sapiens) (c-x-c motif chemokine receptor 1 (homo sapiens)) (aka c-x-c motif chemokine receptor 1)
I: cc-ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
J: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
K: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
L: c-c motif chemokine ligand 13 (homo sapiens) (aka c-c motif chemokine ligand 13)
M: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
N: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
O: c-x-c motif chemokine ligand 13 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
P: ld78 (homo sapiens) (c-c motif chemokine ligand 3 (homo sapiens)) (aka c-c motif chemokine ligand 3)
Q: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
R: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
S: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
T: None of the above. | [A; D; M; A] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: c-x-c motif chemokine ligand 13 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
B: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
C: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
D: ckr-1 (homo sapiens) (c-x-c motif chemokine receptor 1 (homo sapiens)) (aka c-x-c motif chemokine receptor 1)
E: c-c motif chemokine ligand 13 (homo sapiens) (aka c-c motif chemokine ligand 13)
F: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
G: cc-ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
H: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
I: lec1 (drosophila melanogaster) (aka parched)
J: crfr-1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
K: c-c motif chemokine receptor 1 (homo sapiens) (aka c-c motif chemokine receptor 1)
L: lec1 (homo sapiens) (aka adhesion g protein-coupled receptor l2)
M: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
N: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
O: ld78 (homo sapiens) (c-c motif chemokine ligand 3 (homo sapiens)) (aka c-c motif chemokine ligand 3)
P: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
Q: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
R: c-c motif chemokine ligand 26 (homo sapiens) (aka c-c motif chemokine ligand 26)
S: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
T: None of the above. | [M; K; C; M] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: mclc (xenopus tropicalis) (aka chloride channel clic-like 1)
B: lcc (mus musculus) (aka sry (sex determining region y)-box 2)
C: hcc-8 (homo sapiens) (aka tetratricopeptide repeat domain 23)
D: hccs-4 (mus musculus) (aka mitogen-activated protein kinase kinase kinase 20)
E: ldc (mus musculus) (aka lumican)
F: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
G: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
H: mcp-4 (homo sapiens) (aka c-c motif chemokine ligand 13)
I: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
J: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
K: lm (mus musculus) (aka solute carrier family 30 (zinc transporter), member 4)
L: c-c motif chemokine 4 homolog (xenopus tropicalis) (aka c-c motif chemokine 4 homolog)
M: kct-4 (homo sapiens) (aka immunoglobulin superfamily member 8)
N: scya4 (homo sapiens) (aka c-c motif chemokine ligand 4)
O: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
P: lec1 (homo sapiens) (aka adhesion g protein-coupled receptor l2)
Q: None of the above. | [I; I; I; I] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
B: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
C: mcp-4 (homo sapiens) (aka c-c motif chemokine ligand 13)
D: ldc (mus musculus) (aka lumican)
E: c-c motif chemokine 4 homolog (xenopus tropicalis) (aka c-c motif chemokine 4 homolog)
F: scya4 (homo sapiens) (aka c-c motif chemokine ligand 4)
G: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
H: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
I: lec1 (drosophila melanogaster) (aka parched)
J: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
K: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
L: lmc (mus musculus) (aka c-c motif chemokine ligand 16, pseudogene)
M: xcmyc (xenopus laevis) (myc proto-oncogene, bhlh transcription factor l homeolog (xenopus laevis)) (aka myc proto-oncogene, bhlh transcription factor l homeolog)
N: mclc (xenopus tropicalis) (aka chloride channel clic-like 1)
O: hcc-8 (homo sapiens) (aka tetratricopeptide repeat domain 23)
P: None of the above. | [B; B; B; B] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
B: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
C: hcc-8 (homo sapiens) (aka tetratricopeptide repeat domain 23)
D: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
E: scya4 (homo sapiens) (aka c-c motif chemokine ligand 4)
F: c-c motif chemokine 4 homolog (xenopus tropicalis) (aka c-c motif chemokine 4 homolog)
G: mcp-4 (homo sapiens) (aka c-c motif chemokine ligand 13)
H: lec1 (drosophila melanogaster) (aka parched)
I: lmc (mus musculus) (aka c-c motif chemokine ligand 16, pseudogene)
J: ldc (mus musculus) (aka lumican)
K: mclc (xenopus tropicalis) (aka chloride channel clic-like 1)
L: xcmyc (xenopus laevis) (myc proto-oncogene, bhlh transcription factor l homeolog (xenopus laevis)) (aka myc proto-oncogene, bhlh transcription factor l homeolog)
M: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
N: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
O: None of the above. | [O; O; O; O] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
B: lmnc (xenopus tropicalis) (aka lamin a/c)
C: c-c motif chemokine 4 homolog (xenopus tropicalis) (aka c-c motif chemokine 4 homolog)
D: hcc-8 (homo sapiens) (aka tetratricopeptide repeat domain 23)
E: lcc (mus musculus) (aka sry (sex determining region y)-box 2)
F: mcp-4 (homo sapiens) (aka c-c motif chemokine ligand 13)
G: ncc-4 (mus musculus) (aka c-c motif chemokine ligand 16, pseudogene)
H: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
I: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
J: kct-4 (homo sapiens) (aka immunoglobulin superfamily member 8)
K: ldc (homo sapiens) (aka lumican)
L: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
M: scya4 (homo sapiens) (aka c-c motif chemokine ligand 4)
N: lmc (mus musculus) (aka c-c motif chemokine ligand 16, pseudogene)
O: lec1 (homo sapiens) (aka adhesion g protein-coupled receptor l2)
P: None of the above. | [L; L; L; L] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
B: mclc (xenopus tropicalis) (aka chloride channel clic-like 1)
C: c-c motif chemokine 4 homolog (xenopus tropicalis) (aka c-c motif chemokine 4 homolog)
D: lcc (mus musculus) (aka sry (sex determining region y)-box 2)
E: c-c motif chemokine ligand 4 (homo sapiens) (aka c-c motif chemokine ligand 4)
F: lec1 (homo sapiens) (aka adhesion g protein-coupled receptor l2)
G: kct-4 (homo sapiens) (aka immunoglobulin superfamily member 8)
H: lmnc (xenopus tropicalis) (aka lamin a/c)
I: hcc-4 (mus musculus) (aka c-c motif chemokine ligand 16, pseudogene)
J: ldc (homo sapiens) (aka lumican)
K: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
L: scya4 (homo sapiens) (aka c-c motif chemokine ligand 4)
M: hcc-1 (homo sapiens) (aka c-c motif chemokine ligand 14)
N: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
O: hcc-8 (homo sapiens) (aka tetratricopeptide repeat domain 23)
P: lce (homo sapiens) (aka elovl fatty acid elongase 6)
Q: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
R: None of the above. | [K; K; K; K] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ccl16]
<Options>: A: c-x-c motif chemokine ligand 16 (homo sapiens) (aka c-x-c motif chemokine ligand 16)
B: scya16 (homo sapiens) (aka c-c motif chemokine ligand 16)
C: c-c motif chemokine ligand 16 (sus scrofa) (aka c-c motif chemokine ligand 16)
D: ck16 (homo sapiens) (aka keratin 16)
E: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
F: None of the above. | [B] |
<Instruct>: Given the context 'Previously, LEC was shown to induce leukocyte migration but the responsible signaling receptors were not characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec]
<Options>: A: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
B: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
C: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
D: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
E: lce (homo sapiens) (aka elovl fatty acid elongase 6)
F: None of the above. | [C] |
<Instruct>: Given the context 'Previously, LEC was shown to induce leukocyte migration but the responsible signaling receptors were not characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec]
<Options>: A: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
B: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
C: lce (homo sapiens) (aka elovl fatty acid elongase 6)
D: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
E: None of the above. | [E] |
<Instruct>: Given the context 'We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: c-c-ckr-1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
B: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
C: ccr1 (homo sapiens) (aka c-c motif chemokine receptor 1)
D: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
E: crfr-1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
F: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
G: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
H: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
I: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
J: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
K: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
L: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
M: ccr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
N: ccr8 (homo sapiens) (aka c-c motif chemokine receptor 8)
O: None of the above. | [G; C; N] |
<Instruct>: Given the context 'We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
B: ckr-1 (homo sapiens) (c-x-c motif chemokine receptor 1 (homo sapiens)) (aka c-x-c motif chemokine receptor 1)
C: ccr8 (homo sapiens) (aka c-c motif chemokine receptor 8)
D: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
E: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
F: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
G: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
H: lec1 (homo sapiens) (aka adhesion g protein-coupled receptor l2)
I: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
J: cc-ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
K: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
L: ckr-1 (homo sapiens) (c-c motif chemokine receptor 1 (homo sapiens)) (aka c-c motif chemokine receptor 1)
M: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
N: crfr-1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
O: None of the above. | [A; L; C] |
<Instruct>: Given the context 'We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
B: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
C: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
D: lce (homo sapiens) (aka elovl fatty acid elongase 6)
E: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
F: lec1 (drosophila melanogaster) (aka parched)
G: ckr-1 (homo sapiens) (c-x-c motif chemokine receptor 1 (homo sapiens)) (aka c-x-c motif chemokine receptor 1)
H: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
I: cc-ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
J: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
K: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
L: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
M: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
N: ckr-1 (homo sapiens) (c-c motif chemokine receptor 1 (homo sapiens)) (aka c-c motif chemokine receptor 1)
O: None of the above. | [M; N; A] |
<Instruct>: Given the context 'LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
B: cc-ckr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
C: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
D: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
E: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
F: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
G: ckr-1 (homo sapiens) (c-c motif chemokine receptor 1 (homo sapiens)) (aka c-c motif chemokine receptor 1)
H: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
I: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
J: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
K: ccr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
L: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
M: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
N: c-c-ckr-1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
O: None of the above. | [I; G; B] |
<Instruct>: Given the context 'LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
B: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
C: c-c-ckr-1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
D: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
E: cc-ckr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
F: ccr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
G: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
H: lec1 (drosophila melanogaster) (aka parched)
I: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
J: ckr1 (homo sapiens) (aka c-c motif chemokine receptor 1)
K: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
L: crfr-1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
M: lce (homo sapiens) (aka elovl fatty acid elongase 6)
N: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
O: None of the above. | [K; J; E] |
<Instruct>: Given the context 'LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: lce (homo sapiens) (aka elovl fatty acid elongase 6)
B: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
C: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
D: cc-ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
E: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
F: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
G: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
H: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
I: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
J: cc-ckr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
K: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
L: ccr1 (homo sapiens) (aka c-c motif chemokine receptor 1)
M: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
N: c-c-ckr-1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
O: None of the above. | [H; L; J] |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; rantes; i309]
<Options>: A: scya7 (homo sapiens) (aka c-c motif chemokine ligand 7)
B: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
C: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
D: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
E: rantes (sus scrofa) (aka c-c motif chemokine ligand 5)
F: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
G: rantes (xenopus tropicalis) (aka chemokine (c-c motif) ligand 5)
H: ccl25 (homo sapiens) (aka c-c motif chemokine ligand 25)
I: e330027i09 (mus musculus) (aka fibronectin 1)
J: vista enhancer hs309 (homo sapiens) (aka vista enhancer hs309)
K: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
L: lce (homo sapiens) (aka elovl fatty acid elongase 6)
M: b1309 (escherichia coli str. k-12 substr. mg1655) (aka glucosylglycerate phosphorylase)
N: znf309 (homo sapiens) (aka zinc finger with krab and scan domains 3)
O: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
P: None of the above. | [B; K; D] |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; rantes; i309]
<Options>: A: c-c motif chemokine 3 (sus scrofa) (aka c-c motif chemokine 3)
B: znf309 (homo sapiens) (aka zinc finger with krab and scan domains 3)
C: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
D: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
E: rantes (xenopus tropicalis) (aka chemokine (c-c motif) ligand 5)
F: scya5 (homo sapiens) (aka c-c motif chemokine ligand 5)
G: e330027i09 (mus musculus) (aka fibronectin 1)
H: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
I: i-309 (mus musculus) (aka c-c motif chemokine ligand 1)
J: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
K: lec1 (homo sapiens) (aka adhesion g protein-coupled receptor l2)
L: lec1 (drosophila melanogaster) (aka parched)
M: l(2r)ia109 (drosophila melanogaster) (aka jun-related antigen)
N: ccl25 (homo sapiens) (aka c-c motif chemokine ligand 25)
O: scya6 (homo sapiens) (aka c-c motif chemokine ligand 7)
P: None of the above. | [C; F; D] |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; rantes; i309]
<Options>: A: lec1 (drosophila melanogaster) (aka parched)
B: ccl5 (homo sapiens) (aka c-c motif chemokine ligand 5)
C: b1309 (escherichia coli str. k-12 substr. mg1655) (aka glucosylglycerate phosphorylase)
D: rantes (sus scrofa) (aka c-c motif chemokine ligand 5)
E: i-309 (mus musculus) (aka c-c motif chemokine ligand 1)
F: rantes (xenopus tropicalis) (aka chemokine (c-c motif) ligand 5)
G: znf309 (homo sapiens) (aka zinc finger with krab and scan domains 3)
H: lce (homo sapiens) (aka elovl fatty acid elongase 6)
I: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
J: e330027i09 (mus musculus) (aka fibronectin 1)
K: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
L: lec1 (homo sapiens) (aka adhesion g protein-coupled receptor l2)
M: c-c motif chemokine 3 (sus scrofa) (aka c-c motif chemokine 3)
N: ccl25 (homo sapiens) (aka c-c motif chemokine ligand 25)
O: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
P: None of the above. | [I; B; K] |
<Instruct>: Given the context 'A neutralizing polyclonal antibody to LEC was developed to demonstrate that the unusually high concentration of LEC required to induce chemotaxis was a property of LEC and not as a result of an irrelevant protein contamination.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec]
<Options>: A: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
B: lce (homo sapiens) (aka elovl fatty acid elongase 6)
C: lec1 (drosophila melanogaster) (aka parched)
D: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
E: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
F: None of the above. | [D] |
<Instruct>: Given the context 'This study suggests that LEC may be a more effective inducer of cell adhesion than cell migration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec]
<Options>: A: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
B: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
C: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
D: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
E: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
F: None of the above. | [A] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 gene product, ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: hhr6b (homo sapiens) (aka ubiquitin conjugating enzyme e2 b)
B: dnaj homolog (drosophila melanogaster) (aka dnaj homolog)
C: mjdp1 (mus musculus) (aka dnaj heat shock protein family (hsp40) member c12)
D: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
E: ataxin-3 (mus musculus) (aka ataxin 3)
F: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
G: hhr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
H: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
I: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
J: hhr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
K: hh2r (homo sapiens) (aka histamine receptor h2)
L: mjd (mus musculus) (aka ataxin 3)
M: nr3b (homo sapiens) (aka glutamate ionotropic receptor nmda type subunit 3b)
N: ataxin 3 (sus scrofa) (aka ataxin 3)
O: hr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
P: mjl-1 (caenorhabditis elegans) (aka abc2_membrane domain-containing protein)
Q: atx3 (homo sapiens) (aka ataxin 3)
R: hr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
S: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
T: None of the above. | [Q; Q; O; G] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 gene product, ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: sca3 (homo sapiens) (aka ataxin 3)
C: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
D: dnaj homolog (drosophila melanogaster) (aka dnaj homolog)
E: hsd3b2 (homo sapiens) (aka hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2)
F: hhr6b (homo sapiens) (aka ubiquitin conjugating enzyme e2 b)
G: mjl-1 (caenorhabditis elegans) (aka abc2_membrane domain-containing protein)
H: hhr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
I: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
J: hh2r (homo sapiens) (aka histamine receptor h2)
K: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
L: mjdp1 (mus musculus) (aka dnaj heat shock protein family (hsp40) member c12)
M: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
N: hhr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
O: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
P: hr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
Q: dnaj homolog subfamily b member 1 (caenorhabditis elegans) (aka dnaj homolog subfamily b member 1)
R: ataxin 3 (mus musculus) (aka ataxin 3)
S: None of the above. | [B; B; H; N] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 gene product, ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: hhr6b (homo sapiens) (aka ubiquitin conjugating enzyme e2 b)
B: dnaj homolog subfamily b member 1 (caenorhabditis elegans) (aka dnaj homolog subfamily b member 1)
C: hr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
D: ataxin 3 (mus musculus) (aka ataxin 3)
E: mjds (homo sapiens) (aka lipin 2)
F: atxn3 (homo sapiens) (aka ataxin 3)
G: hsd3b2 (homo sapiens) (aka hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2)
H: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
I: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
J: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
K: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
L: nr3b2 (homo sapiens) (aka estrogen related receptor beta)
M: rad23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
N: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
O: mjd (mus musculus) (aka ataxin 3)
P: hr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
Q: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
R: mjl-1 (caenorhabditis elegans) (aka abc2_membrane domain-containing protein)
S: None of the above. | [F; F; C; M] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 gene product, ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
B: mjdl (homo sapiens) (aka ataxin 3 like)
C: hh2r (homo sapiens) (aka histamine receptor h2)
D: hhr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
E: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
F: mjl-1 (caenorhabditis elegans) (aka abc2_membrane domain-containing protein)
G: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
H: mjdp1 (mus musculus) (aka dnaj heat shock protein family (hsp40) member c12)
I: ataxin 3 (homo sapiens) (aka ataxin 3)
J: ataxin 3 (sus scrofa) (aka ataxin 3)
K: mjds (homo sapiens) (aka lipin 2)
L: hhr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
M: ataxin 3 (mus musculus) (aka ataxin 3)
N: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
O: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
P: nr3b (homo sapiens) (aka glutamate ionotropic receptor nmda type subunit 3b)
Q: rad23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
R: hhr6b (homo sapiens) (aka ubiquitin conjugating enzyme e2 b)
S: None of the above. | [I; I; D; Q] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 gene product, ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mjd1; ataxin-3]
<Options>: A: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
B: mjds (homo sapiens) (aka lipin 2)
C: mjdp1 (mus musculus) (aka dnaj heat shock protein family (hsp40) member c12)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: ataxin-3 (mus musculus) (aka ataxin 3)
F: mjdl (homo sapiens) (aka ataxin 3 like)
G: dnaj homolog subfamily b member 1 (caenorhabditis elegans) (aka dnaj homolog subfamily b member 1)
H: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
I: mjd (homo sapiens) (aka ataxin 3)
J: None of the above. | [I; I] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 gene product, ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mjd1; ataxin-3]
<Options>: A: mjd (mus musculus) (aka ataxin 3)
B: dnaj homolog subfamily b member 1 (caenorhabditis elegans) (aka dnaj homolog subfamily b member 1)
C: ataxin 3 (sus scrofa) (aka ataxin 3)
D: dnaj homolog (drosophila melanogaster) (aka dnaj homolog)
E: mjdp1 (mus musculus) (aka dnaj heat shock protein family (hsp40) member c12)
F: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
G: ataxin-3 (mus musculus) (aka ataxin 3)
H: mjd (homo sapiens) (aka ataxin 3)
I: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
J: None of the above. | [H; H] |
<Instruct>: Given the context 'The mutant ataxin-3 forms intranuclear inclusions in cultured cells as well as in diseased human brain and also causes cell death in transfected cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3]
<Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
C: sca3 (homo sapiens) (aka ataxin 3)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: ataxin-3 (mus musculus) (aka ataxin 3)
F: None of the above. | [C] |
<Instruct>: Given the context 'The mutant ataxin-3 forms intranuclear inclusions in cultured cells as well as in diseased human brain and also causes cell death in transfected cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3]
<Options>: A: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
B: ataxin-3 (mus musculus) (aka ataxin 3)
C: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
D: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
E: None of the above. | [E] |
<Instruct>: Given the context 'However, the normal function of ataxin-3 remains unknown.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3]
<Options>: A: ataxin-3 (mus musculus) (aka ataxin 3)
B: ataxin 3 (homo sapiens) (aka ataxin 3)
C: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
D: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
E: ataxin 3 (sus scrofa) (aka ataxin 3)
F: None of the above. | [B] |
<Instruct>: Given the context 'To explore the function of ataxin-3, we used the two-hybrid system to screen for the protein(s) that interacts with ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3]
<Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
C: ataxin 3 (sus scrofa) (aka ataxin 3)
D: ataxin 3 (homo sapiens) (aka ataxin 3)
E: ataxin-3 (mus musculus) (aka ataxin 3)
F: None of the above. | [D] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: hr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
B: nr3b2 (homo sapiens) (aka estrogen related receptor beta)
C: rad23 nucleotide excision repair protein a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
D: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
E: hhr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
F: hh2r (homo sapiens) (aka histamine receptor h2)
G: ataxin 3 (sus scrofa) (aka ataxin 3)
H: tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3 (saccharomyces cerevisiae s288c) (aka tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3)
I: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
J: ataxin-3 (mus musculus) (aka ataxin 3)
K: cell division cycle protein 23 homolog (caenorhabditis elegans) (aka cell division cycle protein 23 homolog)
L: rad23 (saccharomyces cerevisiae s288c) (aka rad23p)
M: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
N: dhr23 (drosophila melanogaster) (rad23 (drosophila melanogaster)) (aka rad23)
O: ataxin 3 (homo sapiens) (aka ataxin 3)
P: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
Q: rad23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
R: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
S: None of the above. | [O; L; C; Q] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: hhr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
B: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
C: rad23 nucleotide excision repair protein a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: hhr6b (homo sapiens) (aka ubiquitin conjugating enzyme e2 b)
F: tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3 (saccharomyces cerevisiae s288c) (aka tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3)
G: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
H: atxn3 (homo sapiens) (aka ataxin 3)
I: ataxin 3 (sus scrofa) (aka ataxin 3)
J: rad23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
K: cell division cycle protein 23 homolog (caenorhabditis elegans) (aka cell division cycle protein 23 homolog)
L: rad23p (saccharomyces cerevisiae s288c) (aka rad23p)
M: hr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
N: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
O: nr3b (homo sapiens) (aka glutamate ionotropic receptor nmda type subunit 3b)
P: nr3b2 (homo sapiens) (aka estrogen related receptor beta)
Q: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
R: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
S: dhr23 (drosophila melanogaster) (rad23 (drosophila melanogaster)) (aka rad23)
T: None of the above. | [H; L; C; M] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
B: hhr6b (homo sapiens) (aka ubiquitin conjugating enzyme e2 b)
C: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
D: rad23 nucleotide excision repair protein a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
E: nr3b (homo sapiens) (aka glutamate ionotropic receptor nmda type subunit 3b)
F: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
G: nr3b2 (homo sapiens) (aka estrogen related receptor beta)
H: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
I: hr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
J: tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3 (saccharomyces cerevisiae s288c) (aka tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3)
K: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
L: rad23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
M: hhr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
N: rad23p (saccharomyces cerevisiae s288c) (aka rad23p)
O: cell division cycle protein 23 homolog (caenorhabditis elegans) (aka cell division cycle protein 23 homolog)
P: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
Q: ataxin 3 (sus scrofa) (aka ataxin 3)
R: dhr23 (drosophila melanogaster) (rad23 (drosophila melanogaster)) (aka rad23)
S: None of the above. | [S; N; D; I] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
B: rad23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
C: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
D: hh2r (homo sapiens) (aka histamine receptor h2)
E: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
F: cell division cycle protein 23 homolog (caenorhabditis elegans) (aka cell division cycle protein 23 homolog)
G: hr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
H: rad23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
I: nr3b2 (homo sapiens) (aka estrogen related receptor beta)
J: ataxin 3 (mus musculus) (aka ataxin 3)
K: ataxin 3 (sus scrofa) (aka ataxin 3)
L: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
M: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
N: ataxin 3 (homo sapiens) (aka ataxin 3)
O: hr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
P: dhr23 (drosophila melanogaster) (rad23 (drosophila melanogaster)) (aka rad23)
Q: hhr6b (homo sapiens) (aka ubiquitin conjugating enzyme e2 b)
R: rad23 (saccharomyces cerevisiae s288c) (aka rad23p)
S: hhr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
T: None of the above. | [N; R; G; B] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: hr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
B: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
C: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
D: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
E: cell division cycle protein 23 homolog (caenorhabditis elegans) (aka cell division cycle protein 23 homolog)
F: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
G: ataxin-3 (mus musculus) (aka ataxin 3)
H: rad23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
I: tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3 (saccharomyces cerevisiae s288c) (aka tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3)
J: hhr6b (homo sapiens) (aka ubiquitin conjugating enzyme e2 b)
K: ataxin 3 (sus scrofa) (aka ataxin 3)
L: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
M: nr3b (homo sapiens) (aka glutamate ionotropic receptor nmda type subunit 3b)
N: rad23p (saccharomyces cerevisiae s288c) (aka rad23p)
O: ataxin 3 (homo sapiens) (aka ataxin 3)
P: dhr23 (drosophila melanogaster) (rad23 (drosophila melanogaster)) (aka rad23)
Q: rad23 nucleotide excision repair protein a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
R: hsd3b2 (homo sapiens) (aka hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2)
S: None of the above. | [O; N; Q; H] |
<Instruct>: Given the context 'Furthermore, we confirmed that ataxin-3 interacts with the -ubiquitin-like domain at the N-terminus of the HHR23 proteins, which is important for nucleotide excision repair; however, ataxin-3 does not interact with -ubiquitin, implying that ataxin-3 might be functionally associated with the HHR23 proteins through this specific interaction.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3]
<Options>: A: ataxin 3 (mus musculus) (aka ataxin 3)
B: ataxin 3 (sus scrofa) (aka ataxin 3)
C: atxn3 (homo sapiens) (aka ataxin 3)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
F: None of the above. | [C] |
<Instruct>: Given the context 'The normal and mutant ataxin-3 proteins show no difference in their ability to bind to the HHR23 proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3]
<Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: atx3 (homo sapiens) (aka ataxin 3)
C: ataxin-3 (mus musculus) (aka ataxin 3)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
F: None of the above. | [B] |
<Instruct>: Given the context 'The normal and mutant ataxin-3 proteins show no difference in their ability to bind to the HHR23 proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3]
<Options>: A: ataxin-3 (mus musculus) (aka ataxin 3)
B: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
C: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: None of the above. | [E] |
<Instruct>: Given the context 'However, in 293 cells HHR23A is recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hhr23a; ataxin-3]
<Options>: A: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
B: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
C: ataxin 3 (homo sapiens) (aka ataxin 3)
D: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
E: hr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
F: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
G: hr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
H: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
I: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
J: ataxin 3 (sus scrofa) (aka ataxin 3)
K: None of the above. | [E; C] |
<Instruct>: Given the context 'However, in 293 cells HHR23A is recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hhr23a; ataxin-3]
<Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
C: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
D: atxn3 (homo sapiens) (aka ataxin 3)
E: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
F: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
G: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
H: hr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
I: ataxin 3 (sus scrofa) (aka ataxin 3)
J: hhr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
K: None of the above. | [H; D] |
<Instruct>: Given the context 'These results suggest that this interaction is associated with the normal function of ataxin-3 and that some functional abnormality of the HHR23 proteins might exist in MJD.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3]
<Options>: A: ataxin 3 (homo sapiens) (aka ataxin 3)
B: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
C: ataxin 3 (sus scrofa) (aka ataxin 3)
D: ataxin 3 (mus musculus) (aka ataxin 3)
E: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
F: None of the above. | [A] |
<Instruct>: Given the context 'Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells.
X-linked retinoschisis is characterized by microcystic-like changes of the macular region and schisis within the inner retinal layers, leading to visual deterioration in males.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [retinoschisin; x-linked retinoschisis protein; x-linked retinoschisis]
<Options>: A: rs1 (mus musculus) (retinoschisis (x-linked, juvenile) 1 (human) (mus musculus)) (aka retinoschisis (x-linked, juvenile) 1 (human))
B: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
C: retinitis pigmentosa 6 (x-linked recessive) (homo sapiens) (aka retinitis pigmentosa 6 (x-linked recessive))
D: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
E: x-linked retinitis pigmentosa gtpase regulator homolog (caenorhabditis elegans) (aka x-linked retinitis pigmentosa gtpase regulator homolog)
F: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
G: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
H: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
I: retinoschisin 1a (danio rerio) (aka retinoschisin 1a)
J: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
K: None of the above. | [D; D; D] |
<Instruct>: Given the context 'Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells.
X-linked retinoschisis is characterized by microcystic-like changes of the macular region and schisis within the inner retinal layers, leading to visual deterioration in males.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [retinoschisin; x-linked retinoschisis protein; x-linked retinoschisis]
<Options>: A: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
B: retinoschisin 1 (bos taurus) (aka retinoschisin 1)
C: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
D: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
E: retinoschisin 1 l homeolog (xenopus laevis) (aka retinoschisin 1 l homeolog)
F: x-linked retinitis pigmentosa gtpase regulator homolog (caenorhabditis elegans) (aka x-linked retinitis pigmentosa gtpase regulator homolog)
G: retinal dystrophy, x-linked, gardener-hardcastle type (homo sapiens) (aka retinal dystrophy, x-linked, gardener-hardcastle type)
H: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
I: retinoschisis (x-linked, juvenile) 1 (human) (mus musculus) (aka retinoschisis (x-linked, juvenile) 1 (human))
J: None of the above. | [C; C; C] |
<Instruct>: Given the context 'Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells.
X-linked retinoschisis is characterized by microcystic-like changes of the macular region and schisis within the inner retinal layers, leading to visual deterioration in males.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [retinoschisin; x-linked retinoschisis protein; x-linked retinoschisis]
<Options>: A: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
B: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
C: retinoschisin 1 l homeolog (xenopus laevis) (aka retinoschisin 1 l homeolog)
D: retinal dystrophy, x-linked, gardener-hardcastle type (homo sapiens) (aka retinal dystrophy, x-linked, gardener-hardcastle type)
E: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
F: x-linked retinitis pigmentosa gtpase regulator homolog (caenorhabditis elegans) (aka x-linked retinitis pigmentosa gtpase regulator homolog)
G: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
H: retinoschisin 1 (homo sapiens) (aka retinoschisin 1)
I: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
J: None of the above. | [H; H; H] |
<Instruct>: Given the context 'Many missense and protein-truncating mutations of the causative gene RS1 have now been identified and are thought to be inactivating.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rs1]
<Options>: A: rs1 (human alphaherpesvirus 1) (transcriptional regulator icp4 (human alphaherpesvirus 1)) (aka transcriptional regulator icp4)
B: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
C: rsrc1 (homo sapiens) (aka arginine and serine rich coiled-coil 1)
D: rsrp1 (homo sapiens) (aka arginine and serine rich protein 1)
E: rsf1 (homo sapiens) (aka remodeling and spacing factor 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'RS1 encodes a 224 amino acid protein, retinoschisin, which contains a discoidin domain but is of unknown function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rs1; retinoschisin]
<Options>: A: rs1 (human alphaherpesvirus 1) (transcriptional regulator icp4 (human alphaherpesvirus 1)) (aka transcriptional regulator icp4)
B: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
C: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
D: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
E: retinoschisin 1a (danio rerio) (aka retinoschisin 1a)
F: rs1 (homo sapiens) (regulator of solute carriers 1 (homo sapiens)) (aka regulator of solute carriers 1)
G: rsts1 (homo sapiens) (aka creb binding lysine acetyltransferase)
H: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
I: rsrc1 (homo sapiens) (aka arginine and serine rich coiled-coil 1)
J: None of the above. | [B; B] |
<Instruct>: Given the context 'RS1 encodes a 224 amino acid protein, retinoschisin, which contains a discoidin domain but is of unknown function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rs1; retinoschisin]
<Options>: A: retinoschisin 1 (bos taurus) (aka retinoschisin 1)
B: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
C: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
D: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
E: rs1 (human alphaherpesvirus 1) (transcriptional regulator icp4 (human alphaherpesvirus 1)) (aka transcriptional regulator icp4)
F: rsg1 (homo sapiens) (aka ciliogenesis and planar polarity effector complex subunit 2)
G: rsts1 (homo sapiens) (aka creb binding lysine acetyltransferase)
H: rsrp1 (homo sapiens) (aka arginine and serine rich protein 1)
I: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
J: None of the above. | [C; C] |
<Instruct>: Given the context 'We have generated a polyclonal antibody against a peptide from a unique region within retinoschisin, which detects a protein of approximately 28 kDa in retinal samples reduced with dithiothreitol, but multimers sized >40 kDa under non-reducing conditions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [retinoschisin]
<Options>: A: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
B: rs (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
C: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
D: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
E: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'We have generated a polyclonal antibody against a peptide from a unique region within retinoschisin, which detects a protein of approximately 28 kDa in retinal samples reduced with dithiothreitol, but multimers sized >40 kDa under non-reducing conditions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [retinoschisin]
<Options>: A: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
B: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
C: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
D: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
E: None of the above. | [E] |
<Instruct>: Given the context 'A screen of human tissues with this antibody reveals retinoschisin to be retina specific and the antibody detects a protein of similar size in bovine and murine retinae.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [retinoschisin]
<Options>: A: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
B: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
C: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
D: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
E: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
F: None of the above. | [A] |
<Instruct>: Given the context 'We investigated the expression pattern in the retina of both RS1 mRNA (using in situ hybridization with riboprobes) and retinoschisin (using immunohistochemistry).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rs1; retinoschisin]
<Options>: A: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
B: retinoschisin 1a (danio rerio) (aka retinoschisin 1a)
C: rsrc1 (homo sapiens) (aka arginine and serine rich coiled-coil 1)
D: rsrp1 (homo sapiens) (aka arginine and serine rich protein 1)
E: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
F: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
G: rsts1 (homo sapiens) (aka creb binding lysine acetyltransferase)
H: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
I: rsc1a1 (homo sapiens) (aka regulator of solute carriers 1)
J: None of the above. | [E; E] |
<Instruct>: Given the context 'We investigated the expression pattern in the retina of both RS1 mRNA (using in situ hybridization with riboprobes) and retinoschisin (using immunohistochemistry).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rs1; retinoschisin]
<Options>: A: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
B: rsrc1 (homo sapiens) (aka arginine and serine rich coiled-coil 1)
C: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
D: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
E: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
F: rs1 (homo sapiens) (regulator of solute carriers 1 (homo sapiens)) (aka regulator of solute carriers 1)
G: retinoschisin 1 (bos taurus) (aka retinoschisin 1)
H: rsg1 (homo sapiens) (aka ciliogenesis and planar polarity effector complex subunit 2)
I: rs1 (human alphaherpesvirus 1) (transcriptional regulator icp4 (human alphaherpesvirus 1)) (aka transcriptional regulator icp4)
J: None of the above. | [D; D] |
<Instruct>: Given the context 'The antisense riboprobe detected RS1 mRNA only in the photoreceptor layer but the protein product of the gene was present both in the photoreceptors and within the inner portions of the retina.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rs1]
<Options>: A: rsf1 (homo sapiens) (aka remodeling and spacing factor 1)
B: rsrc1 (homo sapiens) (aka arginine and serine rich coiled-coil 1)
C: rs (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
D: rsts1 (homo sapiens) (aka creb binding lysine acetyltransferase)
E: rs1 (human alphaherpesvirus 1) (transcriptional regulator icp4 (human alphaherpesvirus 1)) (aka transcriptional regulator icp4)
F: None of the above. | [C] |
<Instruct>: Given the context 'Furthermore, differentiated retinoblastoma cells (Weri-Rb1 cells) were found to express RS1 mRNA and to release retinoschisin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rs1; retinoschisin]
<Options>: A: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
B: rs1 (homo sapiens) (regulator of solute carriers 1 (homo sapiens)) (aka regulator of solute carriers 1)
C: rsg1 (homo sapiens) (aka ciliogenesis and planar polarity effector complex subunit 2)
D: retinoschisin 1a (danio rerio) (aka retinoschisin 1a)
E: rsrc1 (homo sapiens) (aka arginine and serine rich coiled-coil 1)
F: rs (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
G: rsf1 (homo sapiens) (aka remodeling and spacing factor 1)
H: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
I: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
J: None of the above. | [F; F] |
<Instruct>: Given the context 'Furthermore, differentiated retinoblastoma cells (Weri-Rb1 cells) were found to express RS1 mRNA and to release retinoschisin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rs1; retinoschisin]
<Options>: A: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
B: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
C: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
D: rsrp1 (homo sapiens) (aka arginine and serine rich protein 1)
E: rs (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
F: rsg1 (homo sapiens) (aka ciliogenesis and planar polarity effector complex subunit 2)
G: rsts1 (homo sapiens) (aka creb binding lysine acetyltransferase)
H: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
I: rs1 (homo sapiens) (regulator of solute carriers 1 (homo sapiens)) (aka regulator of solute carriers 1)
J: None of the above. | [E; E] |
<Instruct>: Given the context 'Furthermore, differentiated retinoblastoma cells (Weri-Rb1 cells) were found to express RS1 mRNA and to release retinoschisin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rs1; retinoschisin]
<Options>: A: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
B: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
C: rsrp1 (homo sapiens) (aka arginine and serine rich protein 1)
D: rsg1 (homo sapiens) (aka ciliogenesis and planar polarity effector complex subunit 2)
E: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
F: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
G: rs1 (homo sapiens) (regulator of solute carriers 1 (homo sapiens)) (aka regulator of solute carriers 1)
H: rsts1 (homo sapiens) (aka creb binding lysine acetyltransferase)
I: None of the above. | [I; I] |
<Instruct>: Given the context 'These results suggest that retinoschisin is released by photo-receptors and has functions within the inner retinal layers.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [retinoschisin]
<Options>: A: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
B: retinoschisin 1 (bos taurus) (aka retinoschisin 1)
C: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
D: retinoschisin 1 (homo sapiens) (aka retinoschisin 1)
E: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'Thus, X-linked retinoschisis is caused by abnormalities in a putative secreted photoreceptor protein and is the first example of a secreted photo-receptor protein associated with a retinal dystrophy.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [x-linked retinoschisis]
<Options>: A: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
B: retinoschisis (x-linked, juvenile) 1 (human) (mus musculus) (aka retinoschisis (x-linked, juvenile) 1 (human))
C: x-linked retinitis pigmentosa gtpase regulator homolog (caenorhabditis elegans) (aka x-linked retinitis pigmentosa gtpase regulator homolog)
D: retinoschisin 1 (homo sapiens) (aka retinoschisin 1)
E: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
F: None of the above. | [D] |
<Instruct>: Given the context 'Identification of a common protein association region in the neuronal Cdk5 activator.
Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5 activator (Nck5a) for kinase activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [neuronal cdk5 activator; cyclin-dependent protein kinase 5; cdk5]
<Options>: A: cdk5ps (homo sapiens) (aka cyclin dependent kinase 5 pseudogene 1)
B: cyclin-dependent kinase 5 (xenopus tropicalis) (aka cyclin-dependent kinase 5)
C: cyclin-dependent-like kinase 5 (caenorhabditis elegans) (aka cyclin-dependent-like kinase 5)
D: p35nck5a (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
E: cdk5r1 (xenopus laevis) (cyclin-dependent kinase 5, regulatory subunit 1 (p35) like s homeolog (xenopus laevis)) (aka cyclin-dependent kinase 5, regulatory subunit 1 (p35) like s homeolog)
F: cyclin dependent kinase like 5 (xenopus tropicalis) (aka cyclin dependent kinase like 5)
G: cyclin-dependent kinase 5, regulatory subunit 1 (p35) (xenopus tropicalis) (aka cyclin-dependent kinase 5, regulatory subunit 1 (p35))
H: cdk5 (xenopus laevis) (aka cyclin-dependent kinase 5 l homeolog)
I: cdk5r1 (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
J: cdk5 (homo sapiens) (aka cyclin dependent kinase 5)
K: cdkl5 (homo sapiens) (aka cyclin dependent kinase like 5)
L: p25 (drosophila melanogaster) (cdk5 activator-like protein (drosophila melanogaster)) (aka cdk5 activator-like protein)
M: None of the above. | [I; J; J] |
<Instruct>: Given the context 'Identification of a common protein association region in the neuronal Cdk5 activator.
Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5 activator (Nck5a) for kinase activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [neuronal cdk5 activator; cyclin-dependent protein kinase 5; cdk5]
<Options>: A: cdk5a (drosophila melanogaster) (aka cdk5 activator-like protein)
B: cdk5r1 (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
C: cyclin-dependent kinase 5 (drosophila melanogaster) (aka cyclin-dependent kinase 5)
D: cdk5p1 (homo sapiens) (aka cyclin dependent kinase 5 pseudogene 1)
E: p35 (drosophila melanogaster) (cdk5 activator-like protein (drosophila melanogaster)) (aka cdk5 activator-like protein)
F: cdk5 (mus musculus) (aka cyclin dependent kinase 5)
G: cdk5r (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
H: cdkl5 (homo sapiens) (aka cyclin dependent kinase like 5)
I: cyclin-dependent kinase 5 (xenopus tropicalis) (aka cyclin-dependent kinase 5)
J: cyclin-dependent kinase 5, regulatory subunit 1 (p35) (xenopus tropicalis) (aka cyclin-dependent kinase 5, regulatory subunit 1 (p35))
K: cyclin dependent kinase 5 (mus musculus) (aka cyclin dependent kinase 5)
L: cyclin dependent kinase 5 (homo sapiens) (aka cyclin dependent kinase 5)
M: cdk5 (xenopus laevis) (aka cyclin-dependent kinase 5 l homeolog)
N: cdk5 (homo sapiens) (aka cyclin dependent kinase 5)
O: None of the above. | [B; L; L] |
<Instruct>: Given the context 'Identification of a common protein association region in the neuronal Cdk5 activator.
Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5 activator (Nck5a) for kinase activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [neuronal cdk5 activator; cyclin-dependent protein kinase 5; cdk5]
<Options>: A: cdk5 (homo sapiens) (aka cyclin dependent kinase 5)
B: cdk5r (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
C: cdk5r1 (xenopus laevis) (cyclin-dependent kinase 5, regulatory subunit 1 (p35) like s homeolog (xenopus laevis)) (aka cyclin-dependent kinase 5, regulatory subunit 1 (p35) like s homeolog)
D: cyclin-dependent kinase 5, regulatory subunit 1 (p35) (xenopus tropicalis) (aka cyclin-dependent kinase 5, regulatory subunit 1 (p35))
E: cdk5a (drosophila melanogaster) (aka cdk5 activator-like protein)
F: cyclin-dependent kinase 5 (drosophila melanogaster) (aka cyclin-dependent kinase 5)
G: p35nck5a (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
H: cdk5ps (homo sapiens) (aka cyclin dependent kinase 5 pseudogene 1)
I: p35 (drosophila melanogaster) (cdk5 activator-like protein (drosophila melanogaster)) (aka cdk5 activator-like protein)
J: cyclin dependent kinase 5 (mus musculus) (aka cyclin dependent kinase 5)
K: cyclin-dependent-like kinase 5 (caenorhabditis elegans) (aka cyclin-dependent-like kinase 5)
L: cdkl5 (homo sapiens) (aka cyclin dependent kinase like 5)
M: cdk5 (drosophila melanogaster) (aka cyclin-dependent kinase 5)
N: None of the above. | [B; A; A] |
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