instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [il-4; il-10; il-17; ifn-gamma]
<Options>: A: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
B: interferon gamma (homo sapiens) (aka interferon gamma)
C: il17 (homo sapiens) (aka interleukin 17a)
D: il-10 (oryctolagus cuniculus) (aka interleukin 10)
E: il-10c (homo sapien... | [K; H; C; B] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: i-tac (mus musculus) (aka chemokine (c-x-c motif) ligand 11)
B: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
D: ifn-alphaa (homo sapiens) (aka interferon alpha 2)
E: ik cytokine (homo sapiens) (aka ik c... | [O; N; H; K] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
B: tnfc (homo sapiens) (aka lymphotoxin beta)
C: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
D: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
E: ip-10 (homo sapie... | [H; G; P; M] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
B: tnfc (homo sapiens) (aka lymphotoxin beta)
C: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
D: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
E: tnf-a ... | [I; G; Q; T] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
B: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
C: ifn-alpha (homo sapiens) (aka interferon alpha 1)
D: mig-6 (homo sapiens) (aka erbb receptor feedback inhibi... | [I; H; P; E] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [ip-10; mig]
<Options>: A: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
B: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
D: mig9 (homo sapiens) (aka s100 calcium binding protein p)
E: il-10c (homo sapiens) (aka interleukin 19)
F: ... | [I; A] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [ip-10; mig]
<Options>: A: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
B: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
C: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
D: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
E: interferon alpha 10 (homo sapiens) (aka... | [C; A] |
<Instruct>: Given the context 'Immunohistochemistry of skin affected by ACD revealed that >70% of infiltrating cells were reactive for CXCR3 and that CXCR3 staining colocalized in CD4+ and CD8+ T cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [cxcr3]
<Options>: A: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
B: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
C: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3... | [D] |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [ifn-gamma; il-4; cxcr3]
<Options>: A: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
B: interleukin 5 (homo sapiens) (aka interleukin 5)
C: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
D: il-4 (homo sapiens) (aka interleukin 4)
E: il-4 (bos t... | [K; D; F] |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [ifn-gamma; il-4; cxcr3]
<Options>: A: interferon gamma (mus musculus) (aka interferon gamma)
B: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
C: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
D: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor... | [O; J; H] |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [ifn-gamma; il-4; cxcr3]
<Options>: A: cd3-gammaamma (homo sapiens) (aka cd3 gamma subunit of t-cell receptor complex)
B: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma)
C: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
D: il-4 (homo sapiens) (aka interleukin 4)
E: bolf1 (human ... | [J; D; N] |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously t... | <Mentions>: [cxcr3; ifn-gamma; il-4]
<Options>: A: interferon gamma (gallus gallus) (aka interferon gamma)
B: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
C: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
D: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
E: bdlf4 (human ga... | [G; M; F] |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously t... | <Mentions>: [cxcr3; ifn-gamma; il-4]
<Options>: A: interferon gamma (homo sapiens) (aka interferon gamma)
B: interferon gamma (sus scrofa) (aka interferon gamma)
C: interleukin 5 (homo sapiens) (aka interleukin 5)
D: il-4 (homo sapiens) (aka interleukin 4)
E: interferon gamma (oryctolagus cuniculus) (aka interferon gam... | [N; A; D] |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously t... | <Mentions>: [cxcr3; ifn-gamma; il-4]
<Options>: A: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
B: interleukin 4 (homo sapiens) (aka interleukin 4)
C: cd3-gammaamma (homo sapiens) (aka cd3 gamma subunit of t-cell receptor complex)
D: interferon gamma (homo s... | [L; D; B] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: tnfc (homo sapiens) (aka lymphotoxin beta)
B: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
C: interleukin 5 (homo sapiens) (aka interleukin 5)
D: ifi10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
E: il-10c (... | [S; R; O; D] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
B: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
C: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
D: bdlf4 (human gammaherp... | [O; M; Q; L] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
B: tnf (homo sapiens) (aka tumor necrosis factor)
C: il-10c (homo sapiens) (aka interleukin 19)
D: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
E: bllf1 (human... | [F; P; B; Q] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
B: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
C: interferon gamma (homo sapiens) (aka interferon gamma)
D: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
E: bllf1 (human gammaherpe... | [H; C; L; M] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
B: c-x-c motif chemokine ligand 10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: ifn-gamma (gallus gallus) (aka interferon)
D: bolf1 (human gammaherpesvirus 4) (... | [P; M; T; B] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
B: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
C: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
D: i-tac (homo sapiens) (aka c... | [K; D; G] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
B: tac1 (homo sapiens) (aka tachykinin precursor 1)
C: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
D: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
E: mig-6 (mus musculu... | [G; I; F] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
B: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
C: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
D: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine r... | [G; N; J] |
<Instruct>: Given the context 'The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [graf; mll]
<Options>: A: mll (homo sapiens) (aka lysine methyltransferase 2a)
B: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
C: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
D: g... | [I; A] |
<Instruct>: Given the context 'The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [graf; mll]
<Options>: A: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
B: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
C: grap (homo sapiens) (aka grb2 related adaptor protein)
D: graf1 (homo sapiens) (aka rho gtpase activatin... | [D; I] |
<Instruct>: Given the context 'We have isolated the human GRAF gene (for GTPase regulator associated with the focal adhesion kinase pp125(FAK)).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
B: grap (homo sapiens) (aka grb2 related adaptor protein)
C: graf (homo sapiens) (aka rho gtpase activating protein 26)
D: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1... | [C] |
<Instruct>: Given the context 'This gene was fused with MLL in a unique t(5;11)(q31;q23) that occurred in an infant with juvenile myelomonocytic leukemia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [mll]
<Options>: A: mllt7 (homo sapiens) (aka forkhead box o4)
B: mll1 (homo sapiens) (aka lysine methyltransferase 2a)
C: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
D: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
E: myeloid/lymphoid or mixed-lineage leukemi... | [B] |
<Instruct>: Given the context 'GRAF encodes a member of the Rho family of the GTPase-activating protein (GAP) family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf (homo sapiens) (aka rho gtpase activating protein 26)
B: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
C: graf (xenopus tropicalis) (aka rho gtpase activating protein 26)
D: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
E: grap (... | [A] |
<Instruct>: Given the context 'On the protein level, it is 90% homologous to the recently described chicken GRAF gene that functions as a GAP of RhoA in vivo and is thus a critical component of the integrin signaling transduction pathway.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [graf; rhoa]
<Options>: A: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
B: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
C: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
D: rhoa-a (xenopus laevis) (ras homolog family member a l homeolog (... | [K; K] |
<Instruct>: Given the context 'On the protein level, it is 90% homologous to the recently described chicken GRAF gene that functions as a GAP of RhoA in vivo and is thus a critical component of the integrin signaling transduction pathway.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [graf; rhoa]
<Options>: A: rho (drosophila melanogaster) (rho1 (drosophila melanogaster)) (aka rho1)
B: graf (homo sapiens) (aka rho gtpase activating protein 26)
C: ras homolog family member a (xenopus tropicalis) (aka ras homolog family member a)
D: graf2 (homo sapiens) (aka rho gtpase activating protein ... | [K; K] |
<Instruct>: Given the context 'The particular position of the human GRAF gene at 5q31 and the proposed antiproliferative and tumor suppressor properties of its avian homologue suggest that it also might be pathogenetically relevant for hematologic malignancies with deletions of 5q.', select the correct biomedical conce... | <Mentions>: [graf]
<Options>: A: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
B: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
C: grap (homo sapiens) (aka grb2 related adaptor protein)
D: graf (homo sapiens) (aka rho gtpase activating protein 26)
E: graf-1ef (homo s... | [D] |
<Instruct>: Given the context 'To investigate this possibility, we sequenced 4-5 individual cDNA clones from 13 cases in which one allele of GRAF was deleted.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [graf]
<Options>: A: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
B: graf (homo sapiens) (aka rho gtpase activating protein 26)
C: grap (homo sapiens) (aka grb2 related adaptor protein)
D: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1... | [B] |
<Instruct>: Given the context 'We found point mutations within the GAP domain of the second GRAF allele in one patient.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: grap (homo sapiens) (aka grb2 related adaptor protein)
B: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
C: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
D: graf1 (xenopus tropicalis) (aka rho gtpase activating protein 26)
E: grf1 (homo sapiens) (aka ras prote... | [B] |
<Instruct>: Given the context 'In two additional patients we found an insertion of 52 or 74 bp within the GRAF cDNA that generates a reading frame shift followed by a premature stop codon.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [graf]
<Options>: A: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
B: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
C: grap (homo sapiens) (aka grb2 related adaptor protein)
D: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
E: graf (xenopus tropi... | [B] |
<Instruct>: Given the context 'GRAF maps outside the previously defined commonly deleted 5q31 region.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf1 (xenopus tropicalis) (aka rho gtpase activating protein 26)
B: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
C: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
D: graf-1ef (homo sapiens) (aka eukaryotic translation elongation fa... | [E] |
<Instruct>: Given the context 'Nevertheless, inactivation of both alleles in at least some cases suggests that deletions and mutations of the GRAF gene may be instrumental in the development and progression of hematopoeitic disorders with a del(5q).', select the correct biomedical concept for each mention using the pro... | <Mentions>: [graf]
<Options>: A: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
B: graf (xenopus tropicalis) (aka rho gtpase activating protein 26)
C: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
D: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasi... | [A] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
B: c-c motif chemokine ligand 26 (homo sapiens) (aka c-c motif chemokine ligand 26)
C: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
D: cc-ckr-9 (homo sapiens) (aka c-c motif chemok... | [E; L; F; E] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
B: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
C: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
D: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif ch... | [G; L; S; G] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
B: cc-ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
C: lec1 (drosophila melanogaster) (aka parched)
D: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
E: 6ckine (... | [P; R; I; P] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
B: c-c motif chemokine 21-like (xenopus tropicalis) (aka c-c motif chemokine 21-like)
C: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
D: ccr1 (homo sapiens) (aka c-c motif ch... | [A; D; M; A] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: c-x-c motif chemokine ligand 13 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
B: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
C: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
D: ckr-1 (homo sapiens) (c-x-c motif chemok... | [M; K; C; M] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: mclc (xenopus tropicalis) (aka chloride channel clic-like 1)
B: lcc (mus musculus) (aka sry (sex determining region y)-box 2)
C: hcc-8 (homo sapiens) (aka tetratricopeptide repeat domain 23)
D: hccs-4 (mus musculus) (aka mitogen-activated protein kinase kinase kinase 2... | [I; I; I; I] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
B: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
C: mcp-4 (homo sapiens) (aka c-c motif chemokine ligand 13)
D: ldc (mus musculus) (aka lumican)
E: c-c motif chemokine 4 homolog (xenopus tropicalis) ... | [B; B; B; B] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
B: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
C: hcc-8 (homo sapiens) (aka tetratricopeptide repeat domain 23)
D: cc-ckr-4 (h... | [O; O; O; O] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
B: lmnc (xenopus tropicalis) (aka lamin a/c)
C: c-c motif chemokine 4 homolog (xenopus tropicalis) (aka c-c motif chemokine 4 homolog)
D: hcc-8 (homo sapiens) (aka tetratricopeptide repea... | [L; L; L; L] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
B: mclc (xenopus tropicalis) (aka chloride channel clic-like 1)
C: c-c motif chemokine 4 homolog (xenopus tropicalis) (aka c-c motif chemokine 4 ... | [K; K; K; K] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [ccl16]
<Options>: A: c-x-c motif chemokine ligand 16 (homo sapiens) (aka c-x-c motif chemokine ligand 16)
B: scya16 (homo sapiens) (aka c-c motif chemokine ligand 16)
C: c-c motif chemokine ligand 16 (sus scrofa) (aka c-c motif chemokine ligand 16)
D: ck16 (homo sapiens) (aka keratin 16)
E: interferon gamm... | [B] |
<Instruct>: Given the context 'Previously, LEC was shown to induce leukocyte migration but the responsible signaling receptors were not characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [lec]
<Options>: A: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
B: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
C: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
D: lec3 (homo sapiens) (aka adhesion g pr... | [C] |
<Instruct>: Given the context 'Previously, LEC was shown to induce leukocyte migration but the responsible signaling receptors were not characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [lec]
<Options>: A: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
B: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
C: lce (homo sapiens) (aka elovl fatty acid elongase 6)
D: b-lec (gallus gallus) (aka c-type lec... | [E] |
<Instruct>: Given the context 'We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: c-c-ckr-1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
B: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
C: ccr1 (homo sapiens) (aka c-c motif chemokine receptor 1)
D: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
E: crfr-1 (homo sapiens) (ak... | [G; C; N] |
<Instruct>: Given the context 'We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
B: ckr-1 (homo sapiens) (c-x-c motif chemokine receptor 1 (homo sapiens)) (aka c-x-c motif chemokine receptor 1)
C: ccr8 (homo sapiens) (aka c-c motif chemokine receptor 8)
D: cc-ckr-4 (homo sapiens) (aka c-c motif chemok... | [A; L; C] |
<Instruct>: Given the context 'We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
B: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
C: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
D: lce (homo sapiens) (aka elovl fatty acid elongase 6)
E: lec-12 (caenorhabditis elegans) (a... | [M; N; A] |
<Instruct>: Given the context 'LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
B: cc-ckr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
C: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
D: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
E: lecd (homo sapiens) ... | [I; G; B] |
<Instruct>: Given the context 'LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
B: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
C: c-c-ckr-1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
D: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
E: cc-ckr-8 (homo sapiens) (... | [K; J; E] |
<Instruct>: Given the context 'LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: lce (homo sapiens) (aka elovl fatty acid elongase 6)
B: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
C: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
D: cc-ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
E: lec3 (homo sapiens)... | [H; L; J] |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [lec; rantes; i309]
<Options>: A: scya7 (homo sapiens) (aka c-c motif chemokine ligand 7)
B: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
C: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
D: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
E: rantes (sus scrofa) (aka c-c m... | [B; K; D] |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [lec; rantes; i309]
<Options>: A: c-c motif chemokine 3 (sus scrofa) (aka c-c motif chemokine 3)
B: znf309 (homo sapiens) (aka zinc finger with krab and scan domains 3)
C: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
D: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
E: rantes (xenopus tro... | [C; F; D] |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [lec; rantes; i309]
<Options>: A: lec1 (drosophila melanogaster) (aka parched)
B: ccl5 (homo sapiens) (aka c-c motif chemokine ligand 5)
C: b1309 (escherichia coli str. k-12 substr. mg1655) (aka glucosylglycerate phosphorylase)
D: rantes (sus scrofa) (aka c-c motif chemokine ligand 5)
E: i-309 (mus musculus... | [I; B; K] |
<Instruct>: Given the context 'A neutralizing polyclonal antibody to LEC was developed to demonstrate that the unusually high concentration of LEC required to induce chemotaxis was a property of LEC and not as a result of an irrelevant protein contamination.', select the correct biomedical concept for each mention usin... | <Mentions>: [lec]
<Options>: A: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
B: lce (homo sapiens) (aka elovl fatty acid elongase 6)
C: lec1 (drosophila melanogaster) (aka parched)
D: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
E: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb regi... | [D] |
<Instruct>: Given the context 'This study suggests that LEC may be a more effective inducer of cell adhesion than cell migration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec]
<Options>: A: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
B: lecd (homo sapiens) (aka mucolipin trp cation channel 1)
C: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
D: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
E: b3 domain-contain... | [A] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: hhr6b (homo sapiens) (aka ubiquitin conjugating enzyme e2 b)
B: dnaj homolog (drosophila melanogaster) (aka dnaj homolog)
C: mjdp1 (mus musculus) (aka dnaj heat shock protein family (hsp40) member c12)
D: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 ... | [Q; Q; O; G] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: sca3 (homo sapiens) (aka ataxin 3)
C: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
D: dnaj homolog (drosophila melanogaster) (aka dnaj homolog)
E: hsd3b2 (homo sapiens) (aka hydro... | [B; B; H; N] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: hhr6b (homo sapiens) (aka ubiquitin conjugating enzyme e2 b)
B: dnaj homolog subfamily b member 1 (caenorhabditis elegans) (aka dnaj homolog subfamily b member 1)
C: hr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
D: ataxin 3 (mus musculus... | [F; F; C; M] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
B: mjdl (homo sapiens) (aka ataxin 3 like)
C: hh2r (homo sapiens) (aka histamine receptor h2)
D: hhr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
E: ataxin-3 homolog (caenorhabditi... | [I; I; D; Q] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [mjd1; ataxin-3]
<Options>: A: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
B: mjds (homo sapiens) (aka lipin 2)
C: mjdp1 (mus musculus) (aka dnaj heat shock protein family (hsp40) member c12)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: ataxin-3 (mus musculus) (aka ataxin 3)
F: mjdl (homo sap... | [I; I] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [mjd1; ataxin-3]
<Options>: A: mjd (mus musculus) (aka ataxin 3)
B: dnaj homolog subfamily b member 1 (caenorhabditis elegans) (aka dnaj homolog subfamily b member 1)
C: ataxin 3 (sus scrofa) (aka ataxin 3)
D: dnaj homolog (drosophila melanogaster) (aka dnaj homolog)
E: mjdp1 (mus musculus) (aka dnaj heat s... | [H; H] |
<Instruct>: Given the context 'The mutant ataxin-3 forms intranuclear inclusions in cultured cells as well as in diseased human brain and also causes cell death in transfected cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [ataxin-3]
<Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
C: sca3 (homo sapiens) (aka ataxin 3)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: ataxin-3 (mus musculus) (aka ataxin 3)
F: None of the above. | [C] |
<Instruct>: Given the context 'The mutant ataxin-3 forms intranuclear inclusions in cultured cells as well as in diseased human brain and also causes cell death in transfected cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [ataxin-3]
<Options>: A: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
B: ataxin-3 (mus musculus) (aka ataxin 3)
C: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
D: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
E: None of the above. | [E] |
<Instruct>: Given the context 'However, the normal function of ataxin-3 remains unknown.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3]
<Options>: A: ataxin-3 (mus musculus) (aka ataxin 3)
B: ataxin 3 (homo sapiens) (aka ataxin 3)
C: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
D: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
E: ataxin 3 (sus scrofa) (aka ataxin 3)
F: None of the above. | [B] |
<Instruct>: Given the context 'To explore the function of ataxin-3, we used the two-hybrid system to screen for the protein(s) that interacts with ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [ataxin-3]
<Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
C: ataxin 3 (sus scrofa) (aka ataxin 3)
D: ataxin 3 (homo sapiens) (aka ataxin 3)
E: ataxin-3 (mus musculus) (aka ataxin 3)
F: None of the above. | [D] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: hr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
B: nr3b2 (homo sapiens) (aka estrogen related receptor beta)
C: rad23 nucleotide excision repair protein a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
D: hhr21 (homo sapi... | [O; L; C; Q] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: hhr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
B: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
C: rad23 nucleotide excision repair protein a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
D: ataxin 7 like ... | [H; L; C; M] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
B: hhr6b (homo sapiens) (aka ubiquitin conjugating enzyme e2 b)
C: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
D: rad23 nucleotide excision repair protein a (homo sapiens) (aka rad23 n... | [S; N; D; I] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
B: rad23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
C: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
D: hh2r (homo sapiens) (aka histamine receptor h2)
E: hhr6a (homo sapie... | [N; R; G; B] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: hr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
B: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
C: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
D: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homol... | [O; N; Q; H] |
<Instruct>: Given the context 'Furthermore, we confirmed that ataxin-3 interacts with the -ubiquitin-like domain at the N-terminus of the HHR23 proteins, which is important for nucleotide excision repair; however, ataxin-3 does not interact with -ubiquitin, implying that ataxin-3 might be functionally associated with t... | <Mentions>: [ataxin-3]
<Options>: A: ataxin 3 (mus musculus) (aka ataxin 3)
B: ataxin 3 (sus scrofa) (aka ataxin 3)
C: atxn3 (homo sapiens) (aka ataxin 3)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
F: None of the above. | [C] |
<Instruct>: Given the context 'The normal and mutant ataxin-3 proteins show no difference in their ability to bind to the HHR23 proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3]
<Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: atx3 (homo sapiens) (aka ataxin 3)
C: ataxin-3 (mus musculus) (aka ataxin 3)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
F: None of the above. | [B] |
<Instruct>: Given the context 'The normal and mutant ataxin-3 proteins show no difference in their ability to bind to the HHR23 proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3]
<Options>: A: ataxin-3 (mus musculus) (aka ataxin 3)
B: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
C: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: None of the above. | [E] |
<Instruct>: Given the context 'However, in 293 cells HHR23A is recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [hhr23a; ataxin-3]
<Options>: A: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
B: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
C: ataxin 3 (homo sapiens) (aka ataxin 3)
D: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
E: hr23a (homo sapiens) (aka rad23 nucleotide excision repair protein ... | [E; C] |
<Instruct>: Given the context 'However, in 293 cells HHR23A is recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [hhr23a; ataxin-3]
<Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
C: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
D: atxn3 (homo sapiens) (aka ataxin 3)
E: hhr6a (homo sapiens) (aka ubiquitin conjugating en... | [H; D] |
<Instruct>: Given the context 'These results suggest that this interaction is associated with the normal function of ataxin-3 and that some functional abnormality of the HHR23 proteins might exist in MJD.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [ataxin-3]
<Options>: A: ataxin 3 (homo sapiens) (aka ataxin 3)
B: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
C: ataxin 3 (sus scrofa) (aka ataxin 3)
D: ataxin 3 (mus musculus) (aka ataxin 3)
E: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
F: None of the above. | [A] |
<Instruct>: Given the context 'Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells.
X-linked retinoschisis is characterized by microcystic-like changes of the macular region and schisis within the inner retinal layers, leading to visual... | <Mentions>: [retinoschisin; x-linked retinoschisis protein; x-linked retinoschisis]
<Options>: A: rs1 (mus musculus) (retinoschisis (x-linked, juvenile) 1 (human) (mus musculus)) (aka retinoschisis (x-linked, juvenile) 1 (human))
B: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
C: retinitis pigmentosa 6 (x-link... | [D; D; D] |
<Instruct>: Given the context 'Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells.
X-linked retinoschisis is characterized by microcystic-like changes of the macular region and schisis within the inner retinal layers, leading to visual... | <Mentions>: [retinoschisin; x-linked retinoschisis protein; x-linked retinoschisis]
<Options>: A: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
B: retinoschisin 1 (bos taurus) (aka retinoschisin 1)
C: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
D: retinoschis... | [C; C; C] |
<Instruct>: Given the context 'Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells.
X-linked retinoschisis is characterized by microcystic-like changes of the macular region and schisis within the inner retinal layers, leading to visual... | <Mentions>: [retinoschisin; x-linked retinoschisis protein; x-linked retinoschisis]
<Options>: A: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
B: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
C: retinoschisin 1 l homeolog (xenopus laevis) (aka retinoschisin 1 l homeolog)
D: retinal dystrophy, x-li... | [H; H; H] |
<Instruct>: Given the context 'Many missense and protein-truncating mutations of the causative gene RS1 have now been identified and are thought to be inactivating.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [rs1]
<Options>: A: rs1 (human alphaherpesvirus 1) (transcriptional regulator icp4 (human alphaherpesvirus 1)) (aka transcriptional regulator icp4)
B: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
C: rsrc1 (homo sapiens) (aka arginine and serine rich coiled-coil 1)
D: rsrp1 (homo... | [B] |
<Instruct>: Given the context 'RS1 encodes a 224 amino acid protein, retinoschisin, which contains a discoidin domain but is of unknown function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rs1; retinoschisin]
<Options>: A: rs1 (human alphaherpesvirus 1) (transcriptional regulator icp4 (human alphaherpesvirus 1)) (aka transcriptional regulator icp4)
B: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
C: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
D: ret... | [B; B] |
<Instruct>: Given the context 'RS1 encodes a 224 amino acid protein, retinoschisin, which contains a discoidin domain but is of unknown function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rs1; retinoschisin]
<Options>: A: retinoschisin 1 (bos taurus) (aka retinoschisin 1)
B: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
C: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
D: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
E: rs1 (human alphaher... | [C; C] |
<Instruct>: Given the context 'We have generated a polyclonal antibody against a peptide from a unique region within retinoschisin, which detects a protein of approximately 28 kDa in retinal samples reduced with dithiothreitol, but multimers sized >40 kDa under non-reducing conditions.', select the correct biomedical c... | <Mentions>: [retinoschisin]
<Options>: A: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
B: rs (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
C: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
D: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
E:... | [B] |
<Instruct>: Given the context 'We have generated a polyclonal antibody against a peptide from a unique region within retinoschisin, which detects a protein of approximately 28 kDa in retinal samples reduced with dithiothreitol, but multimers sized >40 kDa under non-reducing conditions.', select the correct biomedical c... | <Mentions>: [retinoschisin]
<Options>: A: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
B: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
C: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
D: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
E: None of the above. | [E] |
<Instruct>: Given the context 'A screen of human tissues with this antibody reveals retinoschisin to be retina specific and the antibody detects a protein of similar size in bovine and murine retinae.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [retinoschisin]
<Options>: A: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
B: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
C: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
D: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
E: retinoschisin 1 s homeol... | [A] |
<Instruct>: Given the context 'We investigated the expression pattern in the retina of both RS1 mRNA (using in situ hybridization with riboprobes) and retinoschisin (using immunohistochemistry).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [rs1; retinoschisin]
<Options>: A: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
B: retinoschisin 1a (danio rerio) (aka retinoschisin 1a)
C: rsrc1 (homo sapiens) (aka arginine and serine rich coiled-coil 1)
D: rsrp1 (homo sapiens) (aka arginine and serine rich protein 1)
E: rs1 (homo sapiens) (... | [E; E] |
<Instruct>: Given the context 'We investigated the expression pattern in the retina of both RS1 mRNA (using in situ hybridization with riboprobes) and retinoschisin (using immunohistochemistry).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [rs1; retinoschisin]
<Options>: A: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
B: rsrc1 (homo sapiens) (aka arginine and serine rich coiled-coil 1)
C: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
D: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
E: reti... | [D; D] |
<Instruct>: Given the context 'The antisense riboprobe detected RS1 mRNA only in the photoreceptor layer but the protein product of the gene was present both in the photoreceptors and within the inner portions of the retina.', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [rs1]
<Options>: A: rsf1 (homo sapiens) (aka remodeling and spacing factor 1)
B: rsrc1 (homo sapiens) (aka arginine and serine rich coiled-coil 1)
C: rs (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
D: rsts1 (homo sapiens) (aka creb binding lysine acetyltransferase)
E: rs1 (human alp... | [C] |
<Instruct>: Given the context 'Furthermore, differentiated retinoblastoma cells (Weri-Rb1 cells) were found to express RS1 mRNA and to release retinoschisin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [rs1; retinoschisin]
<Options>: A: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
B: rs1 (homo sapiens) (regulator of solute carriers 1 (homo sapiens)) (aka regulator of solute carriers 1)
C: rsg1 (homo sapiens) (aka ciliogenesis and planar polarity effector complex subunit 2)
D: retinoschisin 1a... | [F; F] |
<Instruct>: Given the context 'Furthermore, differentiated retinoblastoma cells (Weri-Rb1 cells) were found to express RS1 mRNA and to release retinoschisin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [rs1; retinoschisin]
<Options>: A: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
B: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
C: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
D: rsrp1 (homo sapiens) (aka arginine and serine rich protein 1)
E: rs (homo sapiens)... | [E; E] |
<Instruct>: Given the context 'Furthermore, differentiated retinoblastoma cells (Weri-Rb1 cells) were found to express RS1 mRNA and to release retinoschisin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [rs1; retinoschisin]
<Options>: A: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
B: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
C: rsrp1 (homo sapiens) (aka arginine and serine rich protein 1)
D: rsg1 (homo sapiens) (aka ciliogenesis and planar polarity effector comp... | [I; I] |
<Instruct>: Given the context 'These results suggest that retinoschisin is released by photo-receptors and has functions within the inner retinal layers.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [retinoschisin]
<Options>: A: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
B: retinoschisin 1 (bos taurus) (aka retinoschisin 1)
C: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
D: retinoschisin 1 (homo sapiens) (aka retinoschisin 1)
E: retinoschisin 1 (xenopus tropic... | [D] |
<Instruct>: Given the context 'Thus, X-linked retinoschisis is caused by abnormalities in a putative secreted photoreceptor protein and is the first example of a secreted photo-receptor protein associated with a retinal dystrophy.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [x-linked retinoschisis]
<Options>: A: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
B: retinoschisis (x-linked, juvenile) 1 (human) (mus musculus) (aka retinoschisis (x-linked, juvenile) 1 (human))
C: x-linked retinitis pigmentosa gtpase regulator homolog (caenorhabditis elegans) (aka x-linked... | [D] |
<Instruct>: Given the context 'Identification of a common protein association region in the neuronal Cdk5 activator.
Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5 activator (Nck5a) for kinase activity.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [neuronal cdk5 activator; cyclin-dependent protein kinase 5; cdk5]
<Options>: A: cdk5ps (homo sapiens) (aka cyclin dependent kinase 5 pseudogene 1)
B: cyclin-dependent kinase 5 (xenopus tropicalis) (aka cyclin-dependent kinase 5)
C: cyclin-dependent-like kinase 5 (caenorhabditis elegans) (aka cyclin-depende... | [I; J; J] |
<Instruct>: Given the context 'Identification of a common protein association region in the neuronal Cdk5 activator.
Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5 activator (Nck5a) for kinase activity.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [neuronal cdk5 activator; cyclin-dependent protein kinase 5; cdk5]
<Options>: A: cdk5a (drosophila melanogaster) (aka cdk5 activator-like protein)
B: cdk5r1 (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
C: cyclin-dependent kinase 5 (drosophila melanogaster) (aka cyclin-dependent kinase... | [B; L; L] |
<Instruct>: Given the context 'Identification of a common protein association region in the neuronal Cdk5 activator.
Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5 activator (Nck5a) for kinase activity.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [neuronal cdk5 activator; cyclin-dependent protein kinase 5; cdk5]
<Options>: A: cdk5 (homo sapiens) (aka cyclin dependent kinase 5)
B: cdk5r (homo sapiens) (aka cyclin dependent kinase 5 regulatory subunit 1)
C: cdk5r1 (xenopus laevis) (cyclin-dependent kinase 5, regulatory subunit 1 (p35) like s homeolog ... | [B; A; A] |
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