instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
|---|---|---|
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: tall-1 (homo sapiens) (aka tnf superfamily member 13b)
B: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
C: fas (gallus gallus) (aka fas cell surface death receptor)
D: fas ligand (homo sapiens) (aka fas ligand)
E: fas (homo sapie... | [K; K; M] |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: fas ligand (homo sapiens) (aka fas ligand)
B: apol2 (homo sapiens) (aka apolipoprotein l2)
C: fas (gallus gallus) (aka fas cell surface death receptor)
D: fasas (homo sapiens) (aka fas antisense rna 1)
E: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme... | [K; K; N] |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: apol2 (homo sapiens) (aka apolipoprotein l2)
B: apo2l (homo sapiens) (aka tnf superfamily member 10)
C: fasn (homo sapiens) (aka fatty acid synthase)
D: tall2 (homo sapiens) (aka tnf superfamily member 13)
E: apo-l (homo sapiens) (aka apolipoprotein l1)
F: trail (ho... | [J; J; B] |
<Instruct>: Given the context 'Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [polypeptide n-acetylgalactosaminyltransferase, galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: polypeptide n-acetylgalactosaminyltransferase 3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransfe... | [A] |
<Instruct>: Given the context 'Here we report the cDNA cloning and expression of a novel GalNAc-transferase termed GalNAc-T3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (drosophila melanogaster) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: polypeptide n-acetylgalactosaminyltransferase 3 (gallus gallus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: udp-n-acetyl-alpha-d-galactosa... | [E] |
<Instruct>: Given the context 'The overall amino acid sequence similarity with GalNAc-T1 and -T2 is approximately 45%; 12 cysteine residues that are shared between GalNAc-T1 and -T2 are also found in GalNAc-T3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 6, gene 3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransferase 6, gene 3)
B: polypeptide n-acetylgalactosaminyltransferase 3 (bos taurus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: polypeptide n-acetylga... | [C] |
<Instruct>: Given the context 'GalNAc-T3 was expressed as a soluble protein without the hydrophobic transmembrane domain in insect cells using a Baculo-virus vector, and the expressed GalNAc-transferase activity showed substrate specificity different from that previously reported for GalNAc-T1 and -T2.', select the cor... | <Mentions>: [galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (drosophila melanogaster) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: polypeptide n-acetylgalactosaminyltransferase 3 (bos taurus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: galnac-t3 (homo sapiens) (aka pol... | [C] |
<Instruct>: Given the context 'Northern analysis of human organs revealed a very restricted expression pattern of GalNAc-T3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: galnac-t3 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: polypeptide n-acetylgalactosaminyltransferase 3 (bos taurus) (aka polypept... | [B] |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Mentions>: [mammalian translation initiation factor 5; eif-5; eukaryotic translation initiation factor 5]
<Options>: A: eukaryotic translation initiation factor 5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translati... | [A; A; A] |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Mentions>: [mammalian translation initiation factor 5; eif-5; eukaryotic translation initiation factor 5]
<Options>: A: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 4e-5 (caenorhabditis elegans) (aka eukaryotic tr... | [G; G; G] |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Mentions>: [mammalian translation initiation factor 5; eif-5; eukaryotic translation initiation factor 5]
<Options>: A: eukaryotic translation initiation factor 5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translati... | [A; A; A] |
<Instruct>: Given the context 'In this paper, the multiple mRNAs that encode mammalian eIF-5 have been characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif-5]
<Options>: A: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
C: eif1p5 (homo sapiens) (aka eukaryotic translation initiation... | [B] |
<Instruct>: Given the context 'In rat tissues, three major eIF-5 mRNAs of 3.5, 2.8, and 2.2 kilobases in length are detected.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif-5]
<Options>: A: eukaryotic translation initiation factor 5 (drosophila melanogaster) (aka eukaryotic translation initiation factor 5)
B: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
C: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryoti... | [E] |
<Instruct>: Given the context 'All major eIF-5 mRNAs are initiated from a single transcription initiation site, contain identical 5'-untranslated and coding regions, but differ from one another only in the length of their 3'-untranslated regions.', select the correct biomedical concept for each mention using the provid... | <Mentions>: [eif-5]
<Options>: A: eif-5a (homo sapiens) (eukaryotic translation initiation factor 5 (homo sapiens)) (aka eukaryotic translation initiation factor 5)
B: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
C: eukaryotic translation initiation factor... | [A] |
<Instruct>: Given the context 'All major eIF-5 mRNAs are initiated from a single transcription initiation site, contain identical 5'-untranslated and coding regions, but differ from one another only in the length of their 3'-untranslated regions.', select the correct biomedical concept for each mention using the provid... | <Mentions>: [eif-5]
<Options>: A: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
B: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
C: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translatio... | [E] |
<Instruct>: Given the context 'The different lengths of the 3'-untranslated region of eIF-5 mRNAs are generated by the use of alternative polyadenylation signals.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [eif-5]
<Options>: A: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
B: eif-5a (homo sapiens) (eukaryotic translation initiation factor 5 (homo sapiens)) (aka eukaryotic translation initiation factor 5)
C: eukaryotic translation initiation factor... | [B] |
<Instruct>: Given the context 'Additionally, we demonstrate tissue-specific variations in eIF-5 mRNA expression as well as preference for polyadenylation sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [eif-5]
<Options>: A: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
B: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
C: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translati... | [D] |
<Instruct>: Given the context 'These results should lead to increased understanding of the regulation of eIF-5 gene expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif-5]
<Options>: A: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
C: eukaryotic translation initiation factor 5 (homo sapiens) (a... | [C] |
<Instruct>: Given the context 'ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Members of the ICE/Ced-3 gene family are likely effector components of the cell death machinery.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [ice-lap6; granzyme b]
<Options>: A: ice-lap6 (homo sapiens) (aka caspase 9)
B: granzyme b (bos taurus) (aka granzyme b)
C: ice-lap3 (homo sapiens) (aka caspase 7)
D: granzyme b (homo sapiens) (aka granzyme b)
E: ice-lap6 (xenopus tropicalis) (aka caspase 9)
F: granzyme b (granzyme 2, cytotoxic t-lymphocyte... | [A; D] |
<Instruct>: Given the context 'ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Members of the ICE/Ced-3 gene family are likely effector components of the cell death machinery.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [ice-lap6; granzyme b]
<Options>: A: granzyme h (homo sapiens) (aka granzyme h)
B: ice-lap3 (homo sapiens) (aka caspase 7)
C: granzyme b (homo sapiens) (aka granzyme b)
D: casp-8 (homo sapiens) (aka caspase 8)
E: granzyme b-like (rattus norvegicus) (aka granzyme b-like)
F: casp6 (homo sapiens) (aka caspase ... | [G; C] |
<Instruct>: Given the context 'Here, we characterize a novel member of this family designated ICE-LAP6.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ice-lap6]
<Options>: A: ice-lap6 (homo sapiens) (aka caspase 9)
B: casp-7 (homo sapiens) (aka caspase 7)
C: casp16 (homo sapiens) (aka caspase 16, pseudogene)
D: ice-lap6 (xenopus tropicalis) (aka caspase 9)
E: ice-lap6 (mus musculus) (aka caspase 9)
F: None of the above. | [A] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ice-lap6; yama; cpp32; apopain]
<Options>: A: apol (homo sapiens) (aka apolipoprotein l1)
B: death executioner caspase related to apopain/yama (drosophila melanogaster) (aka death executioner caspase related to apopain/yama)
C: apopain (xenopus tropicalis) (aka caspase 3, gene 2)
D: xcpp32 (xenopus tropica... | [I; O; O; O] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ice-lap6; yama; cpp32; apopain]
<Options>: A: casp16 (homo sapiens) (aka caspase 16, pseudogene)
B: death executioner caspase related to apopain/yama (drosophila melanogaster) (aka death executioner caspase related to apopain/yama)
C: caspase-6 (homo sapiens) (aka caspase 6)
D: apol (homo sapiens) (aka apo... | [H; L; L; L] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ice-lap6; yama; cpp32; apopain]
<Options>: A: cuta (homo sapiens) (aka cuta divalent cation tolerance homolog)
B: cpp32b (homo sapiens) (aka caspase 3)
C: apopain (xenopus tropicalis) (aka caspase 3, gene 2)
D: hcp32 (homo sapiens) (aka cycs pseudogene 32)
E: sp32 (homo sapiens) (aka acrosin binding protei... | [H; B; B; B] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ice-lap6; yama; cpp32; apopain]
<Options>: A: chica (homo sapiens) (aka family with sequence similarity 83 member d)
B: apoh (homo sapiens) (aka apolipoprotein h)
C: ice-lap6 (homo sapiens) (aka caspase 9)
D: casp16 (homo sapiens) (aka caspase 16, pseudogene)
E: apool (homo sapiens) (aka apolipoprotein o l... | [C; T; T; T] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ice-lap6; yama; cpp32; apopain]
<Options>: A: apool (homo sapiens) (aka apolipoprotein o like)
B: yama (rattus norvegicus) (aka caspase 3)
C: ice-lap6 (mus musculus) (aka caspase 9)
D: chica (homo sapiens) (aka family with sequence similarity 83 member d)
E: sp32 (homo sapiens) (aka acrosin binding protein... | [J; O; O; O] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [mch2; ice-lap3; mch3; cmh-1]
<Options>: A: transient receptor potential cation channel subfamily c member 3 (homo sapiens) (aka transient receptor potential cation channel subfamily c member 3)
B: cmg-1 (homo sapiens) (aka intraflagellar transport 74)
C: caspase 3 (homo sapiens) (aka caspase 3)
D: casp-7 (... | [R; D; D; D] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [mch2; ice-lap3; mch3; cmh-1]
<Options>: A: hmcn2 (homo sapiens) (aka hemicentin 2)
B: mch2 (mus musculus) (aka caspase 6)
C: cmg-1 (homo sapiens) (aka intraflagellar transport 74)
D: bhlhc1 (homo sapiens) (aka myogenic differentiation 1)
E: mch3 (homo sapiens) (aka caspase 7)
F: ice(rel)iii (homo sapiens) ... | [Q; M; M; M] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [mch2; ice-lap3; mch3; cmh-1]
<Options>: A: mch2r (homo sapiens) (aka melanin concentrating hormone receptor 2)
B: ice(rel)iii (homo sapiens) (aka caspase 5)
C: mch3 (homo sapiens) (aka caspase 7)
D: caspase 3 (drosophila melanogaster) (death related ice-like caspase (drosophila melanogaster)) (aka death re... | [R; J; J; J] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [mch2; ice-lap3; mch3; cmh-1]
<Options>: A: cmh1 (homo sapiens) (aka myosin heavy chain 7)
B: mch2 (mus musculus) (aka caspase 6)
C: ligand-gated chloride channel homolog 3 (drosophila melanogaster) (aka ligand-gated chloride channel homolog 3)
D: caspase 3 (homo sapiens) (aka caspase 3)
E: ice(rel)iii (hom... | [Q; G; G; G] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [mch2; ice-lap3; mch3; cmh-1]
<Options>: A: cmh1 (homo sapiens) (aka myosin heavy chain 7)
B: mch3 (homo sapiens) (aka caspase 7)
C: melanin concentrating hormone receptor 1 (homo sapiens) (aka melanin concentrating hormone receptor 1)
D: hmcn2 (homo sapiens) (aka hemicentin 2)
E: mch3 (mus musculus) (aka c... | [P; P; P; P] |
<Instruct>: Given the context 'Interestingly, ICE-LAP6 contains an active site QACGG pentapeptide, rather than the QACRG pentapeptide shared by other family members.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separat... | <Mentions>: [ice-lap6]
<Options>: A: ice-lap6 (xenopus tropicalis) (aka caspase 9)
B: casp-7 (homo sapiens) (aka caspase 7)
C: ice-lap6 (homo sapiens) (aka caspase 9)
D: casp16 (homo sapiens) (aka caspase 16, pseudogene)
E: ice-lap6 (mus musculus) (aka caspase 9)
F: None of the above. | [C] |
<Instruct>: Given the context 'Overexpression of ICE-LAP6 induces apoptosis in MCF7 breast carcinoma cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ice-lap6]
<Options>: A: ice-lap6 (mus musculus) (aka caspase 9)
B: ice-lap6 (xenopus tropicalis) (aka caspase 9)
C: casp-8 (homo sapiens) (aka caspase 8)
D: ice-lap6 (homo sapiens) (aka caspase 9)
E: casp16 (homo sapiens) (aka caspase 16, pseudogene)
F: None of the above. | [D] |
<Instruct>: Given the context 'More importantly, ICE-LAP6 is proteolytically processed into an active cysteine protease by granzyme B, an important component of cytotoxic T cell-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected option... | <Mentions>: [ice-lap6; granzyme b]
<Options>: A: casp16 (homo sapiens) (aka caspase 16, pseudogene)
B: granzyme h (homo sapiens) (aka granzyme h)
C: cathepsin b (homo sapiens) (aka cathepsin b)
D: ice-lap6 (xenopus tropicalis) (aka caspase 9)
E: granzyme b (rattus norvegicus) (aka granzyme b)
F: ice-lap6 (homo sapiens)... | [F; I] |
<Instruct>: Given the context 'More importantly, ICE-LAP6 is proteolytically processed into an active cysteine protease by granzyme B, an important component of cytotoxic T cell-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected option... | <Mentions>: [ice-lap6; granzyme b]
<Options>: A: ice-lap6 (xenopus tropicalis) (aka caspase 9)
B: ice-lap6 (homo sapiens) (aka caspase 9)
C: ice-lap6 (mus musculus) (aka caspase 9)
D: granzyme b (oryctolagus cuniculus) (aka granzyme b)
E: granzyme h (homo sapiens) (aka granzyme h)
F: granzyme b, pseudogene 2 (rattus no... | [B; H] |
<Instruct>: Given the context 'Once activated, ICE-LAP6 is able to cleave the death substrate poly(ADP-ribose) polymerase into signature apoptotic fragments.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [ice-lap6]
<Options>: A: casp-8 (homo sapiens) (aka caspase 8)
B: ice-lap6 (mus musculus) (aka caspase 9)
C: ice-lap6 (xenopus tropicalis) (aka caspase 9)
D: casp16 (homo sapiens) (aka caspase 16, pseudogene)
E: ice-lap6 (homo sapiens) (aka caspase 9)
F: None of the above. | [E] |
<Instruct>: Given the context 'Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
B: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
C: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and... | [F] |
<Instruct>: Given the context 'We have cloned the peripheral cannabinoid receptor, mCB2, from a mouse splenocyte cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mcb2]
<Options>: A: bmc2 (mus musculus) (aka bone mineral content 2)
B: mcopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
C: mcb1 (homo sapiens) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 4)
D: mc2dn2 (homo sapiens) (aka succinate dehydrogenase complex assembly factor 1)
E: secre... | [F] |
<Instruct>: Given the context 'The 3.7 kb sequence contains an open reading frame encoding a protein of 347 residues sharing 82% overall identity with the only other known peripheral receptor, human CB2 (hCB2) and shorter than hCB2 by 13 amino acids at the carboxyl terminus.', select the correct biomedical concept for ... | <Mentions>: [cb2; hcb2]
<Options>: A: cb2 (homo sapiens) (aka cannabinoid receptor 2)
B: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
C: basal cell carcinoma, susceptibility to, 2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
D: cmkbr2 (homo sapiens) (aka c-c ... | [A; A] |
<Instruct>: Given the context 'The 3.7 kb sequence contains an open reading frame encoding a protein of 347 residues sharing 82% overall identity with the only other known peripheral receptor, human CB2 (hCB2) and shorter than hCB2 by 13 amino acids at the carboxyl terminus.', select the correct biomedical concept for ... | <Mentions>: [cb2; hcb2]
<Options>: A: cpeb2 (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 2)
B: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: cb2 (homo sapiens) (aka cannabinoid receptor 2)
D: cgb2 (homo sapiens) (aka chorionic gonadotropin subunit beta 2)
E: csnb2b (homo sap... | [C; C] |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide an... | <Mentions>: [mcb2; hcb2; cb1]
<Options>: A: csnb2b (homo sapiens) (aka calcium binding protein 4)
B: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
C: mcopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
D: b cell maturation defect 2 (mus musculus) (aka b cell maturation defect 2)
E: protocadherin beta 2 ... | [N; N; G] |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide an... | <Mentions>: [mcb2; hcb2; cb1]
<Options>: A: bmc2 (mus musculus) (aka bone mineral content 2)
B: cannabinoid receptor 1 (rattus norvegicus) (aka cannabinoid receptor 1)
C: mc2 (homo sapiens) (aka melanocortin 5 receptor)
D: cb1a (mus musculus) (aka cannabinoid receptor 1)
E: mcopcb2 (homo sapiens) (aka microphthalmia, c... | [N; N; G] |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide an... | <Mentions>: [mcb2; hcb2; cb1]
<Options>: A: mc2 (homo sapiens) (aka melanocortin 5 receptor)
B: mcopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
C: mc2dn2 (homo sapiens) (aka succinate dehydrogenase complex assembly factor 1)
D: csnb2b (homo sapiens) (aka calcium binding protein 4)
E: basal cell carcinoma, ... | [N; N; F] |
<Instruct>: Given the context 'Both hCB2 and mCB2 mediate agonist-stimulated inhibition of forskolin-induced cAMP production in CHO cell lines permanently expressing the receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [hcb2; mcb2]
<Options>: A: bmch2 (mus musculus) (aka bone mechanical trait 2)
B: mcb1 (homo sapiens) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 4)
C: cbc2 (homo sapiens) (aka nuclear cap binding protein subunit 2)
D: b cell maturation defect 2 (mus musculus) (aka b cell maturation defect 2)
... | [K; K] |
<Instruct>: Given the context 'Both hCB2 and mCB2 mediate agonist-stimulated inhibition of forskolin-induced cAMP production in CHO cell lines permanently expressing the receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [hcb2; mcb2]
<Options>: A: mc2dn2 (homo sapiens) (aka succinate dehydrogenase complex assembly factor 1)
B: hcr2 (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
C: mcop2 (homo sapiens) (aka visual system homeobox 2)
D: mcopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
E: mopcb2 (homo sap... | [K; K] |
<Instruct>: Given the context 'SR 141716A failed to antagonize this activity in either cell line, confirming its specificity for CB1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1]
<Options>: A: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1)
B: cb1 (mus musculus) (aka cannabinoid receptor 1)
C: cannabinoid receptor 1 (rattus norvegicus) (aka cannabinoid receptor 1)
D: None of the above. | [A] |
<Instruct>: Given the context 'The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [glycine receptor beta]
<Options>: A: receptor for activated c kinase 1b (glycine max) (aka receptor for activated c kinase 1b)
B: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
C: guanine nucleotide-binding protein subunit beta (glycine max) (aka guanine nucleotide-binding p... | [D] |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Mentions>: [beta subunit of the human glyr; glyr beta; glyr alpha 1]
<Options>: A: glycine receptor beta (homo sapiens) (aka glycine receptor beta)
B: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
C: gamma-aminobutyric acid type b receptor subunit 2 (homo sapiens) (aka gamma-aminobutyric acid type b recep... | [A; A; J] |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Mentions>: [beta subunit of the human glyr; glyr beta; glyr alpha 1]
<Options>: A: guanine nucleotide-binding protein alpha-1 subunit (glycine max) (aka guanine nucleotide-binding protein alpha-1 subunit)
B: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 l homeolog (xenopus laevis)) (aka glycine receptor alpha 1 l... | [C; C; D] |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Mentions>: [beta subunit of the human glyr; glyr beta; glyr alpha 1]
<Options>: A: gamma-aminobutyric acid type a receptor subunit alpha1 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1)
B: glyb (homo sapiens) (aka solute carrier family 25 member 32)
C: glycine receptor alpha 1 (homo sapiens... | [J; J; C] |
<Instruct>: Given the context 'Neither [3H]strychnine binding nor glycine-gated currents were detected when the human GlyR beta subunit cDNA was expressed in the human embryonic kidney 293 cell line.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [glyr beta]
<Options>: A: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
B: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
C: glrb (homo sapiens) (aka glycine receptor beta)
D: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
E: gababr2 (homo sapiens) (aka ... | [C] |
<Instruct>: Given the context 'However, co-expression of the beta subunit cDNA with the alpha 1 subunit cDNA resulted in expression of functional GlyRs which showed a 4-fold reduction in the EC50 values when compared to alpha 1 homomeric GlyRs.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [alpha 1 homomeric glyrs]
<Options>: A: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 s homeolog (xenopus laevis)) (aka glycine receptor alpha 1 s homeolog)
B: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 l homeolog (xenopus laevis)) (aka glycine receptor alpha 1 l homeolog)
C: guanine nucleotide... | [E] |
<Instruct>: Given the context 'Glycine-gated currents of alpha 1/beta GlyRs were 17-fold less sensitive than homomeric alpha 1 GlyRs to the antagonists picrotoxin, picrotoxinin and picrotin, providing clear evidence that heteromeric alpha 1/beta GlyRs were expressed.', select the correct biomedical concept for each men... | <Mentions>: [alpha 1 glyrs]
<Options>: A: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 s homeolog (xenopus laevis)) (aka glycine receptor alpha 1 s homeolog)
B: glycine receptor alpha 1 (sus scrofa) (aka glycine receptor alpha 1)
C: glycine receptor, alpha 1 (rattus norvegicus) (aka glycine receptor, alpha 1)
D: ... | [E] |
<Instruct>: Given the context 'Glycine-gated currents of alpha 1/beta GlyRs were 17-fold less sensitive than homomeric alpha 1 GlyRs to the antagonists picrotoxin, picrotoxinin and picrotin, providing clear evidence that heteromeric alpha 1/beta GlyRs were expressed.', select the correct biomedical concept for each men... | <Mentions>: [alpha 1 glyrs]
<Options>: A: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
B: glycine receptor, alpha 1 (rattus norvegicus) (aka glycine receptor, alpha 1)
C: glycine receptor alpha 1 (sus scrofa) (aka glycine receptor alpha 1)
D: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 s homeolog (x... | [E] |
<Instruct>: Given the context 'Fluorescence in situ hybridisation was used to localise the gene encoding the human GlyR beta subunit (GLRB) to chromosome 4q32, a position syntenic with mouse chromosome 3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [glyr beta; glrb]
<Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
B: glrb (homo sapiens) (aka glycine receptor beta)
C: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
D: glrb (sus scrofa) (aka glycine receptor beta)
E: gprg1b (homo sapien... | [B; B] |
<Instruct>: Given the context 'Fluorescence in situ hybridisation was used to localise the gene encoding the human GlyR beta subunit (GLRB) to chromosome 4q32, a position syntenic with mouse chromosome 3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [glyr beta; glrb]
<Options>: A: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
B: gl-r (homo sapiens) (aka glucagon receptor)
C: glycine receptor beta (bos taurus) (aka glycine receptor beta)
D: glrb (rattus norvegicus) (aka glycine receptor, beta)
E: glrb (sus scrofa) (aka glycine ... | [H; H] |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [glyr beta; glrb; spastic]
<Options>: A: glrb (sus scrofa) (aka glycine receptor beta)
B: glrb (homo sapiens) (aka glycine receptor beta)
C: glr (homo sapiens) (aka glycine receptor alpha 2)
D: glycine receptor beta (bos taurus) (aka glycine receptor beta)
E: glrb (mus musculus) (aka glycine receptor, beta ... | [M; E; E] |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [glyr beta; glrb; spastic]
<Options>: A: spastic paraplegia 41 (autosomal dominant) (homo sapiens) (aka spastic paraplegia 41 (autosomal dominant))
B: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
C: spastic paraplegia 14 (autosomal recessive) (homo sapiens) (aka spastic paraplegia 14 (auto... | [M; H; H] |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [glyr beta; glrb; spastic]
<Options>: A: glr (homo sapiens) (aka glycine receptor alpha 2)
B: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
C: glrb (mus musculus) (aka glycine receptor, beta subunit)
D: spastic paraplegia 16 (complicated, x-linked recessive) (homo sapiens) (aka spastic paraplegi... | [N; C; C] |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [glyr beta; glrb; spastic]
<Options>: A: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
B: gabrb1 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit beta1)
C: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
D: spastic paraplegia 16 (complicated, x-linked recessive... | [F; H; H] |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [spa]
<Options>: A: spam (homo sapiens) (aka eyes shut homolog)
B: spap (homo sapiens) (aka pdzk1 interacting protein 1)
C: spast.s (xenopus laevis) (aka spastin s homeolog)
D: spax1 (homo sapiens) (aka vesicle associated membrane protein 1)
E: spap1a (homo sapiens) (aka fc receptor like 2)
F: None of the a... | [F] |
<Instruct>: Given the context 'This is consistent with the recent finding that a mutation in the murine GlyR beta subunit causes the spa phenotype.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glyr beta; spa]
<Options>: A: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
B: spaar (homo sapiens) (aka small regulatory polypeptide of amino acid response)
C: spas1 (homo sapiens) (aka spermatogenesis associated 19)
D: spap (homo sapiens) (aka pdzk1 interacting protein 1)
E: spap1a (homo sap... | [K; K] |
<Instruct>: Given the context 'This is consistent with the recent finding that a mutation in the murine GlyR beta subunit causes the spa phenotype.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glyr beta; spa]
<Options>: A: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
B: spa (homo sapiens) (aka surfactant protein a1)
C: spas1 (homo sapiens) (aka spermatogenesis associated 19)
D: glrb (homo sapiens) (aka glycine receptor beta)
E: glyr1 (homo sapiens) (aka glyoxylate reductase 1 h... | [K; K] |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; hcdc46; mcm5]
<Options>: A: ccdc56 (homo sapiens) (aka cytochrome c oxidase assembly factor 3)
B: anaphase promoting complex subunit cdc16 (saccharomyces cerevisiae s288c) (aka anaphase promoting complex subunit cdc16)
C: minichromosome maintenance 5 (drosophila melanogaster) (aka minichromosome mai... | [M; M; M] |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; hcdc46; mcm5]
<Options>: A: ccdc56 (homo sapiens) (aka cytochrome c oxidase assembly factor 3)
B: anaphase promoting complex subunit cdc16 (saccharomyces cerevisiae s288c) (aka anaphase promoting complex subunit cdc16)
C: dna replication licensing factor mcm-5 (caenorhabditis elegans) (aka dna repli... | [E; E; E] |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; hcdc46; mcm5]
<Options>: A: cdc47 (homo sapiens) (aka minichromosome maintenance complex component 7)
B: minichromosome maintenance complex component 5 (mus musculus) (aka minichromosome maintenance complex component 5)
C: cdc6 (homo sapiens) (aka cell division cycle 6)
D: hcp26 (homo sapiens) (aka ... | [K; K; K] |
<Instruct>: Given the context 'We have isolated the complete cDNA sequence encoding the human homolog of the yeast replication protein Cdc46/Mcm5.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; mcm5]
<Options>: A: mcm dna helicase complex subunit mcm6 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm6)
B: cdc46 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm5)
C: cdc47 (homo sapiens) (aka minichromosome maintenance complex component 7)
D:... | [B; B] |
<Instruct>: Given the context 'We have isolated the complete cDNA sequence encoding the human homolog of the yeast replication protein Cdc46/Mcm5.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; mcm5]
<Options>: A: dna replication licensing factor mcm-5 (caenorhabditis elegans) (aka dna replication licensing factor mcm-5)
B: cdc16 (saccharomyces cerevisiae s288c) (aka anaphase promoting complex subunit cdc16)
C: cdc5 (homo sapiens) (aka cell division cycle 5 like)
D: minichromosome maintena... | [F; F] |
<Instruct>: Given the context 'The cDNA was used as a probe for chromosomal fluorescence in situ hybridization (FISH), which localized the human Cdc46 gene (CDC46) to chromosome region 22q13.1-->q13.2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [cdc46]
<Options>: A: cdc16 (homo sapiens) (aka cell division cycle 16)
B: cdc16 (saccharomyces cerevisiae s288c) (aka anaphase promoting complex subunit cdc16)
C: aaa family atpase cdc6 (saccharomyces cerevisiae s288c) (aka aaa family atpase cdc6)
D: p1-cdc46 (homo sapiens) (aka minichromosome maintenance ... | [D] |
<Instruct>: Given the context 'As deduced from the cDNA sequence, human protein hCdc46 is composed of 734 amino acids and contains a central region that is almost 80% identical with the yeast protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [hcdc46]
<Options>: A: cdc36 (homo sapiens) (aka ccr4-not transcription complex subunit 2)
B: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
C: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
D: cdc26 (homo sapiens) (aka... | [B] |
<Instruct>: Given the context 'Immunoprecipitation experiments with hCdc46-specific antibodies confirm that essentially all nuclear hCdc46 proteins form a stable dimeric complex with protein P1Mcm3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [hcdc46; p1mcm3]
<Options>: A: hcp26 (homo sapiens) (aka cycs pseudogene 26)
B: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
C: p1.1-mcm3 (homo sapiens) (aka minichromosome maintenance complex component 7)
D: ccdc46 (homo sapiens) (aka centrosomal protein 112)
E: cdc6 (homo sapi... | [B; G] |
<Instruct>: Given the context 'Immunoprecipitation experiments with hCdc46-specific antibodies confirm that essentially all nuclear hCdc46 proteins form a stable dimeric complex with protein P1Mcm3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [hcdc46; p1mcm3]
<Options>: A: p1.1-mcm3 (homo sapiens) (aka minichromosome maintenance complex component 7)
B: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
C: mmcp-3 (mus musculus) (aka mast cell protease 3)
D: cdc16 (homo sapiens) (aka cell division cycle 16)
E: hcp26 (homo sa... | [B; F] |
<Instruct>: Given the context 'We report herein the presence of kappa opioid receptors (KORs) in human fetal microglia and inhibition of HIV-1 expression in acutely infected microglial cell cultures treated with KOR ligands.', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [kor]
<Options>: A: kor3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
B: oprk (homo sapiens) (aka opioid receptor kappa 1)
C: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
D: kor-3 (homo sapiens) (aka opioid related nociceptin receptor 1)
E: kor (mus musculus) (aka opioid recept... | [B] |
<Instruct>: Given the context 'Using reverse transcriptase-polymerase chain reaction and sequencing analyses, we found that mRNA for the KOR was constitutively expressed in microglia and determined that the nucleotide sequence of the open reading frame was identical to that of the human brain KOR gene.', select the cor... | <Mentions>: [kor]
<Options>: A: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
B: kor-3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
C: kor-1 (homo sapiens) (aka opioid receptor kappa 1)
D: kor (mus musculus) (aka opioid receptor, kappa 1)
E: kor3 (homo sapiens) (aka opioid related nocicepti... | [C] |
<Instruct>: Given the context 'The expression of KOR in microglial cells was confirmed by membrane binding of [3H]U69,593, a kappa-selective ligand, and by indirect immunofluorescence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [kor]
<Options>: A: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
B: kor-3 (homo sapiens) (aka opioid related nociceptin receptor 1)
C: kor (homo sapiens) (aka opioid receptor kappa 1)
D: kor-3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
E: kor (mus musculus) (aka opioid recept... | [C] |
<Instruct>: Given the context 'The expression of KOR in microglial cells was confirmed by membrane binding of [3H]U69,593, a kappa-selective ligand, and by indirect immunofluorescence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [kor]
<Options>: A: kor (mus musculus) (aka opioid receptor, kappa 1)
B: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
C: kor-3 (homo sapiens) (aka opioid related nociceptin receptor 1)
D: kor-3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
E: None of the above. | [E] |
<Instruct>: Given the context 'This antiviral effect of the kappa ligands was blocked by the specific KOR antagonist, nor-binaltrophimine.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kor]
<Options>: A: kor3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
B: kor (mus musculus) (aka opioid receptor, kappa 1)
C: kor1 (homo sapiens) (aka opioid receptor kappa 1)
D: kor3 (homo sapiens) (aka opioid related nociceptin receptor 1)
E: oprk1 (rattus norvegicus) (aka opioid recepto... | [C] |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [p97 subunit of the 26s proteasome; type-1 tumor-necrosis-factor-receptor-associated protein-2; 55.11]
<Options>: A: tnf receptor associated factor 2 (homo sapiens) (aka tnf receptor associated factor 2)
B: ct47.11 (homo sapiens) (aka cancer/testis antigen family 47 member a11)
C: p97 (mus musculus) (valosi... | [D; D; D] |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [p97 subunit of the 26s proteasome; type-1 tumor-necrosis-factor-receptor-associated protein-2; 55.11]
<Options>: A: traf2 (homo sapiens) (tnf receptor associated factor 2 (homo sapiens)) (aka tnf receptor associated factor 2)
B: ct55 (homo sapiens) (aka cancer/testis antigen 55)
C: p97 (homo sapiens) (valo... | [N; N; N] |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [p97 subunit of the 26s proteasome; type-1 tumor-necrosis-factor-receptor-associated protein-2; 55.11]
<Options>: A: predicted gene 5511 (mus musculus) (aka predicted gene 5511)
B: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
C: receptor accessory protein 2 (homo sapiens) (aka recep... | [D; D; D] |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [p97 subunit of the 26s proteasome; type-1 tumor-necrosis-factor-receptor-associated protein-2; 55.11]
<Options>: A: hel55 (homo sapiens) (aka heat shock protein family b (small) member 6)
B: thrap2 (homo sapiens) (aka mediator complex subunit 13l)
C: p95 (homo sapiens) (aka nibrin)
D: hp55 (homo sapiens) (... | [N; N; N] |
<Instruct>: Given the context 'Molecular cloning of cDNA for a new regulatory subunit, designated p97, of the human 26S proteasome showed that the polypeptide consists of 908 amino acid residues with a calculated molecular mass of 100184 Da and an isoelectric point of 4.94.', select the correct biomedical concept for e... | <Mentions>: [p97]
<Options>: A: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
B: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
C: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
D: ec9... | [E] |
<Instruct>: Given the context 'Computer analysis showed that p97 is very similar to type-1 tumor-necrosis-factor (TNF)-receptor-associated protein (TRAP)-2 and 55.11, both of which were identified recently as binding proteins of the cytoplasmic domain of type-1 TNF receptor by yeast two-hybrid screening.', select the c... | <Mentions>: [p97; type-1 tumor-necrosis-factor (tnf)-receptor-associated protein (trap)-2]
<Options>: A: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
B: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
C: tra2a (homo sapiens) (aka transformer 2 alpha homolog)
D: trappc2 (homo sapie... | [G; G] |
<Instruct>: Given the context 'Computer analysis showed that p97 is very similar to type-1 tumor-necrosis-factor (TNF)-receptor-associated protein (TRAP)-2 and 55.11, both of which were identified recently as binding proteins of the cytoplasmic domain of type-1 TNF receptor by yeast two-hybrid screening.', select the c... | <Mentions>: [p97; type-1 tumor-necrosis-factor (tnf)-receptor-associated protein (trap)-2]
<Options>: A: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
B: tnf receptor associated factor 2 (homo sapiens) (aka tnf r... | [A; A] |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [p97; nas1; non-atpase subunit 1]
<Options>: A: nas1 (homo sapiens) (solute carrier family 13 member 1 (homo sapiens)) (aka solute carrier family 13 member 1)
B: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
C: nonu-1 (caenorhabditis elegans) (aka smr domain-containing ... | [K; M; M] |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [p97; nas1; non-atpase subunit 1]
<Options>: A: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
B: nonop1 (homo sapiens) (aka non-pou domain containing, octamer-binding pseudogene 1)
C: map97 (homo sapiens) (aka melanotransferrin)
D: nas2 (homo sapiens) (aka solute carrier family 13 member 4)
... | [E; F; F] |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [p97; nas1; non-atpase subunit 1]
<Options>: A: anorexia nervosa, susceptibility to, 1 (homo sapiens) (aka anorexia nervosa, susceptibility to, 1)
B: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
C: m... | [B; F; F] |
<Instruct>: Given the context 'Disruption of NAS1 resulted in several phenotypes, including lethality and temperature-sensitive growth, depending on the genetic background of the cells used.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [nas1]
<Options>: A: nas2 (homo sapiens) (aka solute carrier family 13 member 4)
B: nas1 (homo sapiens) (nr2f1 regulatory antisense rna 1 (homo sapiens)) (aka nr2f1 regulatory antisense rna 1)
C: nas1 (homo sapiens) (solute carrier family 13 member 1 (homo sapiens)) (aka solute carrier family 13 member 1)
D... | [E] |
<Instruct>: Given the context 'The human p97 cDNA suppressed the growth defect of nas1 disruptant cells, when expressed from single-copy or multi-copy vectors, indicating that p97 is functionally equivalent to yeast Nas1p.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [p97; nas1p]
<Options>: A: nas1 (xenopus laevis) (solute carrier family 13 member 1 s homeolog (xenopus laevis)) (aka solute carrier family 13 member 1 s homeolog)
B: nas1 (arabidopsis thaliana) (aka nicotianamine synthase 1)
C: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base ... | [G; C] |
<Instruct>: Given the context 'The human p97 cDNA suppressed the growth defect of nas1 disruptant cells, when expressed from single-copy or multi-copy vectors, indicating that p97 is functionally equivalent to yeast Nas1p.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [p97; nas1p]
<Options>: A: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
B: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
C: nas1 (arabidopsis thaliana) (aka nicotianamine synthase 1)
D: p97 (homo sapiens) (proteasome 26s su... | [D; F] |
<Instruct>: Given the context 'Culturing of the temperature-sensitive nas1 cells at the restrictive temperature promoted the accumulation polyubiquitinated cellular proteins, implying that the 26S proteasome requires a functional Nas1p subunit for ubiquitin-dependent proteolysis.', select the correct biomedical concept... | <Mentions>: [nas1p]
<Options>: A: nasp (homo sapiens) (aka nuclear autoantigenic sperm protein)
B: nas5 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn5)
C: nas7 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn9)
D: nas4 (saccharomyces cerevisiae ... | [E] |
<Instruct>: Given the context 'Culturing of the temperature-sensitive nas1 cells at the restrictive temperature promoted the accumulation polyubiquitinated cellular proteins, implying that the 26S proteasome requires a functional Nas1p subunit for ubiquitin-dependent proteolysis.', select the correct biomedical concept... | <Mentions>: [nas1p]
<Options>: A: nas4 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn6)
B: nas7 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn9)
C: nas5 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn5)
D: n... | [E] |
<Instruct>: Given the context 'These results indicate that p97/Nas1p plays an important regulatory role in the function of the 26S proteasome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; nas1p]
<Options>: A: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
B: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
C: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle ... | [J; B] |
<Instruct>: Given the context 'These results indicate that p97/Nas1p plays an important regulatory role in the function of the 26S proteasome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; nas1p]
<Options>: A: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
B: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
C: nasp (homo sapiens) (aka nuclear autoantigenic sperm protein)
D: nas1 (xenopus tropica... | [F; A] |
<Instruct>: Given the context 'Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
Transforming growth factor-beta TGF-beta is the prototype for a family of extracellular proteins that affect cell proliferation and tissue differentiation.', select the correct biomedical concept for each ... | <Mentions>: [tgf-beta; transforming growth factor-beta]
<Options>: A: transforming growth factor beta 1 (xenopus tropicalis) (aka transforming growth factor beta 1)
B: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
C: transforming growth factor beta receptor 3 (homo sapiens) (a... | [E; E] |
<Instruct>: Given the context 'Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
Transforming growth factor-beta TGF-beta is the prototype for a family of extracellular proteins that affect cell proliferation and tissue differentiation.', select the correct biomedical concept for each ... | <Mentions>: [tgf-beta; transforming growth factor-beta]
<Options>: A: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
B: tgf-beta2 (homo sapiens) (aka transforming growth factor beta 2)
C: transforming growth factor beta 1 (xenopus tropicalis) (aka transforming growth factor beta 1)
D: transforming gro... | [F; F] |
<Instruct>: Given the context 'TGF-beta-related factors, including BMP-2/4, Dpp and activin, act through two types of serine/threonine kinase receptors which can form a heteromeric complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [dpp]
<Options>: A: dpp1 (homo sapiens) (aka cathepsin c)
B: dpp (homo sapiens) (dipeptidyl peptidase 7 (homo sapiens)) (aka dipeptidyl peptidase 7)
C: dipeptidyl peptidase 3 (homo sapiens) (aka dipeptidyl peptidase 3)
D: dpp (drosophila melanogaster) (dipeptidyl aminopeptidase iii (drosophila melanogaster)... | [E] |
<Instruct>: Given the context 'In Drosophila, Mad is required for signalling by Dpp.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dpp]
<Options>: A: dppii (homo sapiens) (aka dipeptidyl peptidase 7)
B: dppi (homo sapiens) (aka cathepsin c)
C: dpp (drosophila melanogaster) (dipeptidyl aminopeptidase iii (drosophila melanogaster)) (aka dipeptidyl aminopeptidase iii)
D: dpp3 (homo sapiens) (aka dipeptidyl peptidase 3)
E: None of the abo... | [E] |
<Instruct>: Given the context 'We have isolated complementary DNAs for four human Mad homologues, one of which, hMAD-4, is identical to DPC-4, a candidate tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [hmad-4; dpc-4]
<Options>: A: dpc4 (mus musculus) (aka smad family member 4)
B: ahd-4 (mus musculus) (aka aldehyde dehydrogenase family 3, subfamily a1)
C: dpc4 (xenopus tropicalis) (smad family member 4 (xenopus tropicalis)) (aka smad family member 4)
D: hda-4 (caenorhabditis elegans) (aka histone deacetyl... | [H; H] |
<Instruct>: Given the context 'We have isolated complementary DNAs for four human Mad homologues, one of which, hMAD-4, is identical to DPC-4, a candidate tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [hmad-4; dpc-4]
<Options>: A: defective pharyngeal development protein 4 (caenorhabditis elegans) (aka defective pharyngeal development protein 4)
B: amd4 (homo sapiens) (aka protein kinase cgmp-dependent 2)
C: major affective disorder 4 (homo sapiens) (aka major affective disorder 4)
D: odad4 (homo sapiens... | [G; G] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.