instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'hMAD-3 and -4 synergized to induce strong ligand-independent TGF-beta-like responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tgf-beta]
<Options>: A: ifn-beta (homo sapiens) (aka interferon beta 1)
B: tgfb (homo sapiens) (aka transforming growth factor beta 1)
C: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
D: transforming growth factor beta 3 (homo sapiens) (aka transforming growth fac... | [B] |
<Instruct>: Given the context 'When truncated at their carboxy termini, hMAD-3 and -4 act as dominant-negative inhibitors of the normal TGF-beta response.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [tgf-beta]
<Options>: A: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
B: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
C: tgfb1 (homo sapiens) (aka transforming growth factor beta 1)
D: ifn-beta (homo sapiens) (aka interferon beta 1)
E: None of ... | [C] |
<Instruct>: Given the context 'The activity of hMAD-3 and -4 was regulated by the TGF-beta receptors, and hMAD-3 but not hMAD-4 was phosphorylated and associated with the ligand-bound receptor complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [tgf-beta; hmad-3; hmad-4]
<Options>: A: mamdc3 (homo sapiens) (aka mam domain containing glycosylphosphatidylinositol anchor 1)
B: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
C: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
D: madh4 (homo sapiens) (aka smad family member 4)
E: t... | [M; K; D] |
<Instruct>: Given the context 'The activity of hMAD-3 and -4 was regulated by the TGF-beta receptors, and hMAD-3 but not hMAD-4 was phosphorylated and associated with the ligand-bound receptor complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [tgf-beta; hmad-3; hmad-4]
<Options>: A: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
B: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
C: mad4 (homo sapiens) (aka max dimerization protein 4)
D: hmad-3 (homo sapiens) (aka smad family member 3)
E: mam domain c... | [H; D; G] |
<Instruct>: Given the context 'The activity of hMAD-3 and -4 was regulated by the TGF-beta receptors, and hMAD-3 but not hMAD-4 was phosphorylated and associated with the ligand-bound receptor complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [tgf-beta; hmad-3; hmad-4]
<Options>: A: ifn-beta (homo sapiens) (aka interferon beta 1)
B: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
C: mam3 (homo sapiens) (aka mastermind like transcriptional coactivator 2)
D: mad3 (homo sapiens) (smad family member 3 (homo sapiens)) (aka smad family member 3)
E... | [M; D; J] |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [tgf-beta; dpca-4; hmad-4]
<Options>: A: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
B: amd4 (homo sapiens) (aka protein kinase cgmp-dependent 2)
C: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
D: cell division cycle associated 4 (xenopus... | [I; E; E] |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [tgf-beta; dpca-4; hmad-4]
<Options>: A: ciliary dyskinesia, primary, 4 (homo sapiens) (aka ciliary dyskinesia, primary, 4)
B: dpc4 (homo sapiens) (aka smad family member 4)
C: mad4 (homo sapiens) (aka max dimerization protein 4)
D: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
E: spindle assembly abn... | [J; B; B] |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [tgf-beta; dpca-4; hmad-4]
<Options>: A: d-sas-4 (drosophila melanogaster) (aka spindle assembly abnormal 4)
B: mad4 (homo sapiens) (aka max dimerization protein 4)
C: ifn-beta (homo sapiens) (aka interferon beta 1)
D: major affective disorder 4 (homo sapiens) (aka major affective disorder 4)
E: amd4 (homo ... | [I; J; J] |
<Instruct>: Given the context 'The C5a chemoattractant receptor mediates mucosal defence to infection.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c5a chemoattractant receptor]
<Options>: A: c5ar1 (bos taurus) (aka complement c5a receptor 1)
B: c5r1 (homo sapiens) (aka complement c5a receptor 1)
C: c5ar1 (mus musculus) (aka complement component 5a receptor 1)
D: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
E: c5ar2 (homo sapiens) (aka complemen... | [B] |
<Instruct>: Given the context 'A family of G-protein-coupled chemoattractant receptors is known to mediate the transport and activation of neutrophils and macrophages This family includes receptors for chemokines, such as interleukin-8, bacterial formylated peptides, platelet-activating factor, leukotriene B4, and the ... | <Mentions>: [interleukin-8]
<Options>: A: il18 (homo sapiens) (aka interleukin 18)
B: c-x-c motif chemokine ligand 8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
C: ck-8 (homo sapiens) (aka keratin 8)
D: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
E: il1f8 (homo sapiens) (aka interleukin 36 beta)
F: No... | [B] |
<Instruct>: Given the context 'Here we show that mice deficient in the chemoattractant C5a receptor, in comparison to their wild-type littermates, were unable to clear intrapulmonary-instilled Pseudomonas aeruginosa, despite a marked increase in neutrophil influx, and succumbed to pneumonia.', select the correct biomed... | <Mentions>: [c5a receptor]
<Options>: A: c5ar (mus musculus) (aka complement component 5a receptor 1)
B: c5ar2 (homo sapiens) (aka complement c5a receptor 2)
C: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
D: c5ar (homo sapiens) (aka complement c5a receptor 1)
E: complement c5a receptor 1 (bos taurus) (aka comple... | [D] |
<Instruct>: Given the context 'These C5a-receptor-deficient mice challenged with sublethal inocula of Pseudomonas become superinfected with secondary bacterial strains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [c5a-receptor]
<Options>: A: c5ar2 (homo sapiens) (aka complement c5a receptor 2)
B: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
C: c5ar (mus musculus) (aka complement component 5a receptor 1)
D: c5ar1 (homo sapiens) (aka complement c5a receptor 1)
E: complement c5a receptor 1 (bos taurus) (aka compl... | [D] |
<Instruct>: Given the context 'We conclude that the C5a receptor has a non-redundant function, and is required for mucosal host defence in the lung.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c5a receptor]
<Options>: A: c5ar2 (homo sapiens) (aka complement c5a receptor 2)
B: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
C: c5r1 (homo sapiens) (aka complement c5a receptor 1)
D: c5ar (mus musculus) (aka complement component 5a receptor 1)
E: complement c5a receptor 1 (bos taurus) (aka comple... | [C] |
<Instruct>: Given the context 'Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [lerk-2; eph-related receptor human embryonal kinase 2]
<Options>: A: lerk-6 (homo sapiens) (aka ephrin a2)
B: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
C: epht2 (homo sapiens) (aka eph receptor b1)
D: eph receptor a2 (homo sapiens) (aka eph receptor a2)
E: ephb2 (homo sapiens) (aka eph recep... | [J; F] |
<Instruct>: Given the context 'Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [lerk-2; eph-related receptor human embryonal kinase 2]
<Options>: A: ephrin-b2 (homo sapiens) (aka ephrin b2)
B: lerk7 (homo sapiens) (aka ephrin a5)
C: lerk2 (homo sapiens) (aka ephrin b1)
D: lerk-1 (homo sapiens) (aka ephrin a1)
E: hek2 (homo sapiens) (aka eph receptor b3)
F: etk-2 (homo sapiens) (aka ty... | [C; E] |
<Instruct>: Given the context 'Human embryonal kinase 2 (HEK2) is a protein-tyrosine kinase that is a member of the EPH family of receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [embryonal kinase 2; hek2]
<Options>: A: ethanolamine kinase 2 (gallus gallus) (aka ethanolamine kinase 2)
B: epht2 (homo sapiens) (aka eph receptor b1)
C: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
D: erb-b2 receptor tyrosine kinase 2 (gallus gallus) (aka erb-b2 receptor tyrosine kinase 2)
E:... | [I; I] |
<Instruct>: Given the context 'Human embryonal kinase 2 (HEK2) is a protein-tyrosine kinase that is a member of the EPH family of receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [embryonal kinase 2; hek2]
<Options>: A: etnk2 (homo sapiens) (aka ethanolamine kinase 2)
B: cek2 (homo sapiens) (aka fibroblast growth factor receptor 3)
C: hek3 (homo sapiens) (aka eph receptor a8)
D: hek7 (homo sapiens) (aka eph receptor a5)
E: hek (homo sapiens) (aka eph receptor a3)
F: ephb2 (homo sapi... | [I; I] |
<Instruct>: Given the context 'Transcripts for HEK2 have a wide tissue distribution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2]
<Options>: A: eph receptor b2 (homo sapiens) (aka eph receptor b2)
B: hek (homo sapiens) (aka eph receptor a3)
C: ek2 (homo sapiens) (aka eph receptor b3)
D: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
E: hek7 (homo sapiens) (aka eph receptor a5)
F: None of the above. | [C] |
<Instruct>: Given the context 'In order to analyze functional effects between the LERKs and the HEK2 receptor, we expressed HEK2 cDNA in an interleukin-3-dependent progenitor cell line 32D that grows as single cells in culture.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [hek2; interleukin-3]
<Options>: A: csf3 (homo sapiens) (aka colony stimulating factor 3)
B: il-3 (homo sapiens) (aka interleukin 3)
C: interleukin 2 (homo sapiens) (aka interleukin 2)
D: epht2 (homo sapiens) (aka eph receptor b1)
E: interleukin 7 (homo sapiens) (aka interleukin 7)
F: hek3 (homo sapiens) (a... | [H; B] |
<Instruct>: Given the context 'In order to analyze functional effects between the LERKs and the HEK2 receptor, we expressed HEK2 cDNA in an interleukin-3-dependent progenitor cell line 32D that grows as single cells in culture.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [hek2; interleukin-3]
<Options>: A: hek3 (homo sapiens) (aka eph receptor a8)
B: epht2 (homo sapiens) (aka eph receptor b1)
C: interleukin 2 (homo sapiens) (aka interleukin 2)
D: hek7 (homo sapiens) (aka eph receptor a5)
E: interleukin 7 (homo sapiens) (aka interleukin 7)
F: ehk-2 (homo sapiens) (aka eph re... | [I; J] |
<Instruct>: Given the context 'In order to analyze functional effects between the LERKs and the HEK2 receptor, we expressed HEK2 cDNA in an interleukin-3-dependent progenitor cell line 32D that grows as single cells in culture.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [hek2; interleukin-3]
<Options>: A: il5 (homo sapiens) (aka interleukin 5)
B: hek2 (homo sapiens) (aka eph receptor b3)
C: csf3 (homo sapiens) (aka colony stimulating factor 3)
D: interleukin 2 (homo sapiens) (aka interleukin 2)
E: hek (homo sapiens) (aka eph receptor a3)
F: epht2 (homo sapiens) (aka eph re... | [B; G] |
<Instruct>: Given the context 'Within the group of LERKs, LERK-2 and -5 were shown to bind to HEK2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2]
<Options>: A: hek (homo sapiens) (aka eph receptor a3)
B: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
C: ek2 (homo sapiens) (aka eph receptor b3)
D: ehk-2 (homo sapiens) (aka eph receptor a6)
E: hek3 (homo sapiens) (aka eph receptor a8)
F: None of the above. | [C] |
<Instruct>: Given the context 'Membrane-bound and soluble forms of LERK-2 were demonstrated to signal through HEK2 as judged by receptor phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [lerk-2; hek2]
<Options>: A: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
B: hek3 (homo sapiens) (aka eph receptor a8)
C: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
D: lerk1 (homo sapiens) (aka ephrin a1)
E: ephrin-b2 (homo sapiens) (aka ephrin b2)
F: hek (homo sapiens) (aka eph receptor... | [I; J] |
<Instruct>: Given the context 'Membrane-bound and soluble forms of LERK-2 were demonstrated to signal through HEK2 as judged by receptor phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [lerk-2; hek2]
<Options>: A: lerk2 (homo sapiens) (aka ephrin b1)
B: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
C: lerk7 (homo sapiens) (aka ephrin a5)
D: lerk-4 (homo sapiens) (aka ephrin a4)
E: epht2 (homo sapiens) (aka eph receptor b1)
F: ephrin-b2 (homo sapiens) (aka ephrin b2)
G: lerk1 (h... | [A; I] |
<Instruct>: Given the context 'Coincubation of HEK2 and LERK-2 expressing cells induced cell-cell adhesion and formation of cell aggregates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; lerk-2]
<Options>: A: lerk-6 (homo sapiens) (aka ephrin a2)
B: lerk7 (homo sapiens) (aka ephrin a5)
C: lerk5 (homo sapiens) (aka ephrin b2)
D: hek7 (homo sapiens) (aka eph receptor a5)
E: hek (homo sapiens) (aka eph receptor a3)
F: epht2 (homo sapiens) (aka eph receptor b1)
G: ek2 (homo sapiens) (aka... | [G; I] |
<Instruct>: Given the context 'Coincubation of HEK2 and LERK-2 expressing cells induced cell-cell adhesion and formation of cell aggregates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; lerk-2]
<Options>: A: ephb2 (homo sapiens) (aka eph receptor b2)
B: lerk-1 (homo sapiens) (aka ephrin a1)
C: epht2 (homo sapiens) (aka eph receptor b1)
D: ehk-2 (homo sapiens) (aka eph receptor a6)
E: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
F: lerk-6 (homo sapiens) (aka ephrin a2)
G: ek2 (... | [G; I] |
<Instruct>: Given the context 'This interaction could be inhibited by preincubation of HEK2 expressing cells with soluble LERK-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; lerk-2]
<Options>: A: lerk4 (homo sapiens) (aka ephrin a4)
B: epht2 (homo sapiens) (aka eph receptor b1)
C: lerk-6 (homo sapiens) (aka ephrin a2)
D: ephrin-b2 (homo sapiens) (aka ephrin b2)
E: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
F: ehk-2 (homo sapiens) (aka eph receptor a6)
G: eph rece... | [J; H] |
<Instruct>: Given the context 'This interaction could be inhibited by preincubation of HEK2 expressing cells with soluble LERK-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; lerk-2]
<Options>: A: epht2 (homo sapiens) (aka eph receptor b1)
B: hek (homo sapiens) (aka eph receptor a3)
C: lerk7 (homo sapiens) (aka ephrin a5)
D: lerk2 (homo sapiens) (aka ephrin b1)
E: lerk1 (homo sapiens) (aka ephrin a1)
F: ek2 (homo sapiens) (aka eph receptor b3)
G: lerk-6 (homo sapiens) (ak... | [F; D] |
<Instruct>: Given the context 'Coexpression of HEK2 and LERK-2 in 32D cells showed reduced kinase activity and autophosphorylation of HEK2 compared with the juxtacrine stimulation, which seems to be due to a reduced sensitivity of the receptor.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [hek2; lerk-2]
<Options>: A: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
B: lerk2 (homo sapiens) (aka ephrin b1)
C: ephrin-b2 (homo sapiens) (aka ephrin b2)
D: lerk-6 (homo sapiens) (aka ephrin a2)
E: hek7 (homo sapiens) (aka eph receptor a5)
F: lerk7 (homo sapiens) (aka ephrin a5)
G: hek2 (homo sapi... | [G; B] |
<Instruct>: Given the context 'Coexpression of HEK2 and LERK-2 in 32D cells showed reduced kinase activity and autophosphorylation of HEK2 compared with the juxtacrine stimulation, which seems to be due to a reduced sensitivity of the receptor.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [hek2; lerk-2]
<Options>: A: ephrin-b2 (homo sapiens) (aka ephrin b2)
B: hek (homo sapiens) (aka eph receptor a3)
C: hek7 (homo sapiens) (aka eph receptor a5)
D: ehk-2 (homo sapiens) (aka eph receptor a6)
E: lerk-4 (homo sapiens) (aka ephrin a4)
F: lerk-6 (homo sapiens) (aka ephrin a2)
G: lerk7 (homo sapien... | [H; J] |
<Instruct>: Given the context 'Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myk-1; htk]
<Options>: A: myk1 (homo sapiens) (aka eph receptor b4)
B: htkl (homo sapiens) (aka ephrin b2)
C: tpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)
D: ctk (homo sapiens) (aka megakaryocyte-associated tyrosine kinase)
E: mbk1 (homo sapiens) (aka potassium voltage-gated channel subfamily a me... | [A; A] |
<Instruct>: Given the context 'Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myk-1; htk]
<Options>: A: myk1 (homo sapiens) (aka eph receptor b4)
B: htk-l (homo sapiens) (aka ephrin b2)
C: myk1 (mus musculus) (aka eph receptor b4)
D: htpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)
E: prkmk1 (homo sapiens) (aka mitogen-activated protein kinase kinase 1)
F: ctk (homo sapiens) (... | [A; A] |
<Instruct>: Given the context 'We have recently reported the molecular characterization of a novel murine receptor PTK (myk-1), belonging to the eph-related family, whose expression was differentially regulated during mammary gland development and elevated in invasive mouse mammary tumours.', select the correct biomedi... | <Mentions>: [myk-1]
<Options>: A: mitogen-activated protein kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase kinase 1)
B: myk1 (homo sapiens) (aka eph receptor b4)
C: mbk1 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 1)
D: mitogen-activated protein kinase kina... | [B] |
<Instruct>: Given the context 'In this communication we have investigated the cellular origin of myk-1 expression by in situ hybridisation and RNase protection.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [myk-1]
<Options>: A: myk1 (mus musculus) (aka eph receptor b4)
B: mitogen-activated protein kinase kinase kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 1)
C: mitogen-activated protein kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kin... | [E] |
<Instruct>: Given the context 'Murine antisense myk-1 probe specifically recognised ductal and alveolar epithelium in the resting mouse mammary gland.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [myk-1]
<Options>: A: prkmk1 (homo sapiens) (aka mitogen-activated protein kinase kinase 1)
B: myk1 (mus musculus) (aka eph receptor b4)
C: mitogen-activated protein kinase kinase kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 1)
D: myk1 (homo sapiens) (aka eph rec... | [D] |
<Instruct>: Given the context 'In normal human breast, the expression of htk, the human homologue, was also confined to the secretory luminal epithelial cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [htk]
<Options>: A: ttk protein kinase (homo sapiens) (aka ttk protein kinase)
B: ctk (homo sapiens) (aka megakaryocyte-associated tyrosine kinase)
C: ptk (homo sapiens) (aka protein tyrosine kinase 2 beta)
D: htk (homo sapiens) (aka eph receptor b4)
E: htpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)... | [D] |
<Instruct>: Given the context 'Elevated expression of htk was found in several human breast carcinoma cell lines as well as in primary, high grade, infiltrating, ductal carcinomas of the breast.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [htk]
<Options>: A: htpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)
B: ctk (homo sapiens) (aka megakaryocyte-associated tyrosine kinase)
C: htk (homo sapiens) (aka eph receptor b4)
D: atk (homo sapiens) (aka bruton tyrosine kinase)
E: htkl (homo sapiens) (aka ephrin b2)
F: None of the above. | [C] |
<Instruct>: Given the context 'The specific epithelial expression of the myk-1/htk receptor PTK suggest a specialised role of this eph-related PTK in the differentiation and/or maintenance of secretory epithelium in the adult.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [myk-1; htk]
<Options>: A: mymk (homo sapiens) (aka myomaker, myoblast fusion factor)
B: htk-l (homo sapiens) (aka ephrin b2)
C: ttk protein kinase (homo sapiens) (aka ttk protein kinase)
D: myk1 (mus musculus) (aka eph receptor b4)
E: atk (homo sapiens) (aka bruton tyrosine kinase)
F: myk1 (homo sapiens) (... | [F; F] |
<Instruct>: Given the context 'The specific epithelial expression of the myk-1/htk receptor PTK suggest a specialised role of this eph-related PTK in the differentiation and/or maintenance of secretory epithelium in the adult.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [myk-1; htk]
<Options>: A: htk-l (homo sapiens) (aka ephrin b2)
B: ttk protein kinase (homo sapiens) (aka ttk protein kinase)
C: mitogen-activated protein kinase kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 1)
D: atk (homo sapiens) (aka bruton tyrosine kin... | [I; I] |
<Instruct>: Given the context 'The specific epithelial expression of the myk-1/htk receptor PTK suggest a specialised role of this eph-related PTK in the differentiation and/or maintenance of secretory epithelium in the adult.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [myk-1; htk]
<Options>: A: myk1 (homo sapiens) (aka eph receptor b4)
B: htpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)
C: mymk (homo sapiens) (aka myomaker, myoblast fusion factor)
D: htk-l (homo sapiens) (aka ephrin b2)
E: mitogen-activated protein kinase kinase kinase kinase 1 (homo sapiens) (aka ... | [A; A] |
<Instruct>: Given the context 'Cloning and characterization of a novel human clathrin heavy chain gene (CLTCL).
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cltcl]
<Options>: A: cltc (homo sapiens) (aka clathrin heavy chain)
B: cltcl1 (oryctolagus cuniculus) (aka clathrin heavy chain like 1)
C: cltcl (homo sapiens) (aka clathrin heavy chain like 1)
D: cltcl1.l (xenopus laevis) (aka clathrin heavy chain like 1 l homeolog)
E: chloride channel clic-like 1 (xenopu... | [C] |
<Instruct>: Given the context 'An exon representing a novel clathrin heavy chain gene (CLTCL) was isolated during gene identification studies and transcription mapping of human chromosome 22.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [cltcl]
<Options>: A: cltcl1 (oryctolagus cuniculus) (aka clathrin heavy chain like 1)
B: cltcl1.l (xenopus laevis) (aka clathrin heavy chain like 1 l homeolog)
C: chloride channel clic like 1 (bos taurus) (aka chloride channel clic like 1)
D: cltcl (homo sapiens) (aka clathrin heavy chain like 1)
E: cltc.l... | [D] |
<Instruct>: Given the context 'The location of CLTCL on human chromosome 22 near the region commonly deleted in DiGeorge and other apparent haploinsufficiency syndromes warrants further investigation into its relationship with these developmental disorders.', select the correct biomedical concept for each mention using... | <Mentions>: [cltcl]
<Options>: A: cltcl1 (homo sapiens) (aka clathrin heavy chain like 1)
B: cltcl1 (oryctolagus cuniculus) (aka clathrin heavy chain like 1)
C: cltcl1.l (xenopus laevis) (aka clathrin heavy chain like 1 l homeolog)
D: chloride channel clic like 1 (sus scrofa) (aka chloride channel clic like 1)
E: chlor... | [A] |
<Instruct>: Given the context 'Here, we report the isolation of two Na+/Pi cotransporter cDNAs (RNaPi-1a and RNaPi-1b) from a rat liver cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rpi1 (saccharomyces cerevisiae s288c) (aka rpi1p)
B: rna polymerase i subunit g (homo sapiens) (aka rna polymerase i subunit g)
C: rna polymerase ii subunit b (homo sapiens) (aka rna polymerase ii subunit b)
D: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii sub... | [J; J] |
<Instruct>: Given the context 'Here, we report the isolation of two Na+/Pi cotransporter cDNAs (RNaPi-1a and RNaPi-1b) from a rat liver cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i)
B: rna polymerase ii subunit b (homo sapiens) (aka rna polymerase ii subunit b)
C: protein phosphatase 1 regulatory inhibitor subunit 1b (homo sapiens) (aka protein phosphatase 1 regulatory inhibi... | [K; K] |
<Instruct>: Given the context 'The rat cDNAs encode a polypeptide of 465 amino acids, having 62% and 66% identity with the rabbit NaPi-1 and human kidney Na+/Pi cotransporter, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [napi-1; na+/pi cotransporter]
<Options>: A: npt1 (homo sapiens) (aka solute carrier family 17 member 1)
B: napi-1 (mus musculus) (aka solute carrier family 17 (sodium phosphate), member 1)
C: c-nap1 (homo sapiens) (aka centrosomal protein 250)
D: napi-3 (homo sapiens) (aka solute carrier family 34 member 1... | [K; A] |
<Instruct>: Given the context 'The rat cDNAs encode a polypeptide of 465 amino acids, having 62% and 66% identity with the rabbit NaPi-1 and human kidney Na+/Pi cotransporter, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [napi-1; na+/pi cotransporter]
<Options>: A: nasi-1 (homo sapiens) (aka solute carrier family 13 member 1)
B: c-nap1 (homo sapiens) (aka centrosomal protein 250)
C: napi-1 (homo sapiens) (aka solute carrier family 17 member 1)
D: napi-1 (rattus norvegicus) (aka solute carrier family 17 member 1)
E: npt-1 (h... | [K; E] |
<Instruct>: Given the context 'Northern blot analysis showed that a RNaPi-1a--specific probe detected two major transcripts (2.3 and 1.8 kb), whereas a RNaPi-1b--specific probe hybridized with one transcript (1.8 kb) in rat kidney, liver, and hepatocytes in primary culture.', select the correct biomedical concept for e... | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rna polymerase ii subunit b (homo sapiens) (aka rna polymerase ii subunit b)
B: rpi1p (saccharomyces cerevisiae s288c) (aka rpi1p)
C: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii subunit l)
D: protein phosphatase 1 regulatory inhibitor subunit 1b (homo sapien... | [J; J] |
<Instruct>: Given the context 'Northern blot analysis showed that a RNaPi-1a--specific probe detected two major transcripts (2.3 and 1.8 kb), whereas a RNaPi-1b--specific probe hybridized with one transcript (1.8 kb) in rat kidney, liver, and hepatocytes in primary culture.', select the correct biomedical concept for e... | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: protein phosphatase 1 regulatory inhibitor subunit 1b (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1b)
B: rpi1 (saccharomyces cerevisiae s288c) (aka rpi1p)
C: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i)
D: rpb11a (... | [K; K] |
<Instruct>: Given the context 'Rat liver expressed much higher levels of RNaPi-1a than RNaPi-1b, whereas the converse was true for rat kidney.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rna polymerase ii subunit b (homo sapiens) (aka rna polymerase ii subunit b)
B: rpb11b1 (homo sapiens) (aka rna polymerase ii subunit j2)
C: rna polymerase i subunit g (homo sapiens) (aka rna polymerase i subunit g)
D: rpi1p (saccharomyces cerevisiae s288c) (aka rpi1p)
E: ... | [I; I] |
<Instruct>: Given the context 'Rat liver expressed much higher levels of RNaPi-1a than RNaPi-1b, whereas the converse was true for rat kidney.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: polr2i (homo sapiens) (aka rna polymerase ii subunit i)
B: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h)
C: rii-beta (homo sapiens) (aka protein kinase camp-dependent type ii regulatory subunit beta)
D: protein phosphatase 1 regulatory inhibito... | [K; K] |
<Instruct>: Given the context 'These findings indicate that there are at least two isoforms of RNaPi-1 transcripts expressed in liver and kidney and that the levels of expression of the RNaPi-1a and RNaPi-1b may be controlled by tissue-specific factors.', select the correct biomedical concept for each mention using the... | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii subunit l)
B: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h)
C: rii-beta (homo sapiens) (aka protein kinase camp-dependent type ii regulatory subunit beta)
D: protein phosphatase 1 regul... | [K; K] |
<Instruct>: Given the context 'These findings indicate that there are at least two isoforms of RNaPi-1 transcripts expressed in liver and kidney and that the levels of expression of the RNaPi-1a and RNaPi-1b may be controlled by tissue-specific factors.', select the correct biomedical concept for each mention using the... | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii subunit l)
B: rna polymerase i subunit a (homo sapiens) (aka rna polymerase i subunit a)
C: protein phosphatase 1 regulatory inhibitor subunit 1b (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subun... | [K; K] |
<Instruct>: Given the context 'Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
p50csk is a tyrosine protein kinase (TPK) that represses the activity of Src family TPKs.', select the correct biomedical concept for each mention using t... | <Mentions>: [p50csk; pep]
<Options>: A: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes)
B: pep6 (saccharomyces cerevisiae s288c) (aka corvet complex subunit vps3)
C: prkcsl (homo sapiens) (aka myristoylated alanine rich protein kinase c substrate)
D: p70-s6k (homo sapiens) (aka ribosomal prote... | [F; I] |
<Instruct>: Given the context 'Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
p50csk is a tyrosine protein kinase (TPK) that represses the activity of Src family TPKs.', select the correct biomedical concept for each mention using t... | <Mentions>: [p50csk; pep]
<Options>: A: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
B: prkcsh (homo sapiens) (aka prkcsh beta subunit of glucosidase ii)
C: s6k (homo sapiens) (aka ribosomal protein s6 kinase b1)
D: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a)
E: prkcsl (homo... | [G; A] |
<Instruct>: Given the context 'We previously showed that Csk is a potent negative regulator of antigen receptor signaling in T lymphocytes and that its Src homology (SH) 3 and SH2 domains are required to inhibit these signals.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [csk]
<Options>: A: csk (homo sapiens) (aka c-terminal src kinase)
B: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
C: hck proto-oncogene, src family tyrosine kinase (homo sapiens) (aka hck proto-oncogene, src family tyrosine kinase)
D: csk (xenopus laevis) (c-terminal src kin... | [A] |
<Instruct>: Given the context 'We previously showed that Csk is a potent negative regulator of antigen receptor signaling in T lymphocytes and that its Src homology (SH) 3 and SH2 domains are required to inhibit these signals.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [csk]
<Options>: A: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink)
B: csk (xenopus laevis) (c-terminal src kinase s homeolog (xenopus laevis)) (aka c-terminal src kinase s homeolog)
C: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
D: hck pr... | [E] |
<Instruct>: Given the context 'To test the idea that the Csk SH3 and SH2 domains mediate interactions with other cellular proteins, we attempted to identify Csk-associated polypeptides using the yeast two-hybrid system.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [csk]
<Options>: A: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink)
B: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1)
C: csk (xenopus laevis) (c-terminal src kinase s homeolog (xenopus laevis)) (aka c-termi... | [D] |
<Instruct>: Given the context 'The results of our experiments demonstrated that Csk physically associates with PEP, a protein tyrosine phosphatase (PTP) expressed in hemopoietic cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [csk; pep]
<Options>: A: pepe (homo sapiens) (aka peptidase e)
B: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
C: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
D: csk (mus musculus) (aka c-src tyrosine kinase)
E: csk.s (xenopus laevis) (aka c-terminal sr... | [F; C] |
<Instruct>: Given the context 'The results of our experiments demonstrated that Csk physically associates with PEP, a protein tyrosine phosphatase (PTP) expressed in hemopoietic cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [csk; pep]
<Options>: A: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
B: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
C: csk (mus musculus) (aka c-src tyrosine kinase)
D: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes)... | [E; A] |
<Instruct>: Given the context 'Further analyses revealed that this interaction was mediated by the Csk SH3 domain and by a proline-rich region (PPPLPERTP) in the non-catalytic C-terminal portion of PEP.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [csk; pep]
<Options>: A: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
B: hck proto-oncogene, src family tyrosine kinase (homo sapiens) (aka hck proto-oncogene, src family tyrosine kinase)
C: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes)
D: csk (hom... | [D; A] |
<Instruct>: Given the context 'Further analyses revealed that this interaction was mediated by the Csk SH3 domain and by a proline-rich region (PPPLPERTP) in the non-catalytic C-terminal portion of PEP.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [csk; pep]
<Options>: A: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
B: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
C: csk (homo sapiens) (aka c-terminal src kinase)
D: pep4 (saccharomyces cerevisiae s288c) (aka prot... | [C; F] |
<Instruct>: Given the context 'The association between Csk and PEP was documented in transiently transfected Cos-1 cells and in a variety of cells of hemopoietic lineages, including T cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [csk; pep]
<Options>: A: sck (homo sapiens) (aka shc adaptor protein 2)
B: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
C: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
D: csk (homo sapiens) (aka c-terminal src... | [D; H] |
<Instruct>: Given the context 'The association between Csk and PEP was documented in transiently transfected Cos-1 cells and in a variety of cells of hemopoietic lineages, including T cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [csk; pep]
<Options>: A: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
B: csk (homo sapiens) (aka c-terminal src kinase)
C: peps (homo sapiens) (aka leucine aminopeptidase 3)
D: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
E: pepa (homo sapiens)... | [B; A] |
<Instruct>: Given the context 'Additional analyses demonstrated that the association between Csk and PEP is highly specific.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csk; pep]
<Options>: A: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
B: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
C: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
D: peps (homo sapien... | [H; F] |
<Instruct>: Given the context 'Additional analyses demonstrated that the association between Csk and PEP is highly specific.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csk; pep]
<Options>: A: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes)
B: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink)
C: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
D: tethering complex subunit pep5 (sacchar... | [H; E] |
<Instruct>: Given the context 'Together, these data indicated that PEP may be an effector and/or a regulator of p50csk in T cells and other hemopoietic cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [pep; p50csk]
<Options>: A: sck (homo sapiens) (aka shc adaptor protein 2)
B: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a)
C: p50csk (mus musculus) (aka c-src tyrosine kinase)
D: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes)
E: pepe (homo sapiens) (aka peptidase e)
F:... | [F; I] |
<Instruct>: Given the context 'Together, these data indicated that PEP may be an effector and/or a regulator of p50csk in T cells and other hemopoietic cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [pep; p50csk]
<Options>: A: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
B: prkcsl (homo sapiens) (aka myristoylated alanine rich protein kinase c substrate)
C: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
D: csk (homo sapiens) (aka c-terminal ... | [C; D] |
<Instruct>: Given the context 'Moreover, they allowed the identification of PEP as the first known ligand for the Csk SH3 domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pep; csk]
<Options>: A: csk (homo sapiens) (aka c-terminal src kinase)
B: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
C: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
D: pep4 (saccharomyces cerevisiae s288c) (aka prot... | [G; A] |
<Instruct>: Given the context 'Moreover, they allowed the identification of PEP as the first known ligand for the Csk SH3 domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pep; csk]
<Options>: A: csk.s (xenopus laevis) (aka c-terminal src kinase s homeolog)
B: csk (mus musculus) (aka c-src tyrosine kinase)
C: peps (homo sapiens) (aka leucine aminopeptidase 3)
D: pepe (homo sapiens) (aka peptidase e)
E: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a)
F: pep.5 (homo s... | [F; I] |
<Instruct>: Given the context 'cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [allograft inflammatory factor-1]
<Options>: A: irf-1 (homo sapiens) (aka interferon regulatory factor 1)
B: irt1 (homo sapiens) (allograft inflammatory factor 1 (homo sapiens)) (aka allograft inflammatory factor 1)
C: ifnai1 (homo sapiens) (aka interferon induced protein with tetratricopeptide repeats 1)
D... | [B] |
<Instruct>: Given the context 'Allograft Inflammatory Factor-1 (AIF-1), a gene previously reported to be expressed in rat IFN gamma-activated macrophages.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [allograft inflammatory factor-1; aif-1; ifn gamma]
<Options>: A: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
B: ifn-gamma (gallus gallus) (aka interferon)
C: ifnai1 (homo sapiens) (aka interferon induced protein with tetratricopeptide repeats 1)
D: hcinf1 (homo sapiens) (aka cytochrome ... | [F; F; O] |
<Instruct>: Given the context 'Allograft Inflammatory Factor-1 (AIF-1), a gene previously reported to be expressed in rat IFN gamma-activated macrophages.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [allograft inflammatory factor-1; aif-1; ifn gamma]
<Options>: A: irf-1 (homo sapiens) (aka interferon regulatory factor 1)
B: allograft inflammatory factor 1 like (homo sapiens) (aka allograft inflammatory factor 1 like)
C: aif family member 2 (homo sapiens) (aka aif family member 2)
D: interferon gamma (m... | [M; M; O] |
<Instruct>: Given the context 'Allograft Inflammatory Factor-1 (AIF-1), a gene previously reported to be expressed in rat IFN gamma-activated macrophages.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [allograft inflammatory factor-1; aif-1; ifn gamma]
<Options>: A: ilf-1 (homo sapiens) (aka forkhead box k2)
B: allograft inflammatory factor 1 like (homo sapiens) (aka allograft inflammatory factor 1 like)
C: interferon gamma (xenopus tropicalis) (aka interferon gamma)
D: interferon gamma (mus musculus) (a... | [H; H; O] |
<Instruct>: Given the context 'This human AIF-1 homologue is inducible in serum and cytokine-stimulated human smooth muscle cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [aif-1]
<Options>: A: aif-1 (homo sapiens) (aka allograft inflammatory factor 1)
B: aifl (homo sapiens) (aka aif family member 3)
C: aif (homo sapiens) (aka apoptosis inducing factor mitochondria associated 1)
D: aif family member 2 (homo sapiens) (aka aif family member 2)
E: aif1l (homo sapiens) (aka allog... | [A] |
<Instruct>: Given the context 'Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [neurokinin-3 receptor; neurokinin b]
<Options>: A: neuromedin b (rattus norvegicus) (aka neuromedin b)
B: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3)
C: nk2r (homo sapiens) (aka tachykinin receptor 2)
D: tac3r (homo sapiens) (aka tachykinin receptor 3)
E: tachykinin receptor 3 (rattus no... | [D; I] |
<Instruct>: Given the context 'Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [neurokinin-3 receptor; neurokinin b]
<Options>: A: neuropeptide b (rattus norvegicus) (aka neuropeptide b)
B: nknb (homo sapiens) (aka tachykinin precursor 3)
C: nk-3r (homo sapiens) (aka tachykinin receptor 3)
D: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3)
E: tachykinin receptor 3 (sus ... | [C; B] |
<Instruct>: Given the context 'Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [neurokinin-3 receptor; neurokinin b]
<Options>: A: neuropeptide b (homo sapiens) (aka neuropeptide b)
B: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3)
C: tachykinin receptor 3 (sus scrofa) (aka tachykinin receptor 3)
D: neuropeptide b (rattus norvegicus) (aka neuropeptide b)
E: tachykinin ... | [G; J] |
<Instruct>: Given the context 'In 1992, Xie et al. identified a cDNA sequence in the expression cloning search for the kappa opioid receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kappa opioid receptor]
<Options>: A: opioid receptor, kappa 1 (rattus norvegicus) (aka opioid receptor, kappa 1)
B: opioid receptor, kappa 1 (mus musculus) (aka opioid receptor, kappa 1)
C: kor1 (homo sapiens) (aka opioid receptor kappa 1)
D: opioid related nociceptin receptor 1 (rattus norvegicus) (aka op... | [C] |
<Instruct>: Given the context 'This cDNA was highly homologous to the human neurokinin-3 (NK-3) receptor sequence, and displayed lower homology to NK-1 and NK-2 sequences.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [neurokinin-3 (nk-3) receptor; nk-1; nk-2]
<Options>: A: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3)
B: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
C: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
D: nkna (homo sapiens) (aka tachykinin pr... | [F; H; M] |
<Instruct>: Given the context 'This cDNA was highly homologous to the human neurokinin-3 (NK-3) receptor sequence, and displayed lower homology to NK-1 and NK-2 sequences.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [neurokinin-3 (nk-3) receptor; nk-1; nk-2]
<Options>: A: nkna (homo sapiens) (aka tachykinin precursor 1)
B: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
C: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
D: nkr-p1a (homo sapiens) (aka killer cell lectin like recept... | [G; L; C] |
<Instruct>: Given the context 'This cDNA was highly homologous to the human neurokinin-3 (NK-3) receptor sequence, and displayed lower homology to NK-1 and NK-2 sequences.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [neurokinin-3 (nk-3) receptor; nk-1; nk-2]
<Options>: A: nkna (homo sapiens) (aka tachykinin precursor 1)
B: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3)
C: ntrkr2 (homo sapiens) (aka receptor tyrosine kinase like orphan receptor 2)
D: nkr-p1 (homo sapiens) (aka killer cell lectin like rec... | [H; K; N] |
<Instruct>: Given the context 'This cDNA was highly homologous to the human neurokinin-3 (NK-3) receptor sequence, and displayed lower homology to NK-1 and NK-2 sequences.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [neurokinin-3 (nk-3) receptor; nk-1; nk-2]
<Options>: A: tac1r (homo sapiens) (aka tachykinin receptor 1)
B: nkr (rattus norvegicus) (aka tachykinin receptor 3)
C: nk-2 (homo sapiens) (aka nk2 homeobox 1)
D: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3)
E: nk2 (homo sapiens) (aka tachykinin... | [F; A; O] |
<Instruct>: Given the context 'This sequence was stably expressed in Chinese hamster ovary cells, which do not express neurokinin receptors naturally, and ligand binding and second messenger characteristics were compared with a human NK-3 receptor.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [nk-3 receptor]
<Options>: A: nk3r (mus musculus) (aka tachykinin receptor 3)
B: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
C: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
D: nk-3r (homo sapiens) (aka tachykinin receptor 3)
E: tachykinin receptor 3 (xeno... | [D] |
<Instruct>: Given the context 'The NK-3 receptor homolog bound [3H] senktide with a Kd of 39 nM, similar to that of the NK-3 receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nk-3 receptor]
<Options>: A: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
B: nkr (homo sapiens) (tachykinin receptor 3 (homo sapiens)) (aka tachykinin receptor 3)
C: nk2r (homo sapiens) (aka tachykinin receptor 2)
D: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine ki... | [B] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: nknb (homo sapiens) (aka tachykinin precursor 3)
B: tachykinin precursor 1 (sus scrofa) (aka tachykinin precursor 1)
C: nk3r (mus musculus) (aka tachykinin receptor 3)
D: nk2r (homo sapiens) (aka tachykinin receptor 2)
E: tachykinin rece... | [J; A; H; H] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: tachykinin receptor 1 (homo sapiens) (aka tachykinin receptor 1)
B: nk2r (homo sapiens) (aka tachykinin receptor 2)
C: nkb1b (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and long cytoplasmic tail 1)
D: t... | [J; G; R; R] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: tachykinin precursor 3 (homo sapiens) (aka tachykinin precursor 3)
B: neuromedin b (bos taurus) (aka neuromedin b)
C: neuropeptide b (homo sapiens) (aka neuropeptide b)
D: tachykinin receptor 1 (homo sapiens) (aka tachykinin receptor 1)
... | [K; G; R; R] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: tachykinin receptor 1 (homo sapiens) (aka tachykinin receptor 1)
B: neuropeptide s (rattus norvegicus) (aka neuropeptide s)
C: tachykinin precursor 1 (homo sapiens) (aka tachykinin precursor 1)
D: neuropeptide b (rattus norvegicus) (aka ... | [H; E; C; C] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: tachykinin precursor 1 (homo sapiens) (aka tachykinin precursor 1)
B: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
C: neuromedin b (homo sapiens) (aka neuromedin b)
D: neuropeptide s (rattus norvegicus) (aka ne... | [M; K; A; A] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [neurokinin b]
<Options>: A: nkb1b (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and long cytoplasmic tail 1)
B: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
C: neuromedin b (homo sapiens) (aka neuromedin b)
D: nkb (homo sapiens) (aka tachykinin precursor... | [D] |
<Instruct>: Given the context 'This cell line also bound [125I-MePhe7]neurokinin B; however, neurokinin B was an effective competitor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [neurokinin b]
<Options>: A: nkb1b (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and long cytoplasmic tail 1)
B: neuropeptide b (homo sapiens) (aka neuropeptide b)
C: neuromedin b (rattus norvegicus) (aka neuromedin b)
D: nknb (homo sapiens) (aka tachykinin precursor 3)
E: n... | [D] |
<Instruct>: Given the context 'This cell line also bound [125I-MePhe7]neurokinin B; however, neurokinin B was an effective competitor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [neurokinin b]
<Options>: A: neuropeptide b (rattus norvegicus) (aka neuropeptide b)
B: neuropeptide b (homo sapiens) (aka neuropeptide b)
C: neuromedin b (rattus norvegicus) (aka neuromedin b)
D: nkb1b (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and long cytoplasmic tail ... | [E] |
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical conce... | <Mentions>: [nk-3 receptor; neurokinin b; nka]
<Options>: A: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
B: nkna (xenopus tropicalis) (aka tachykinin precursor 1)
C: nk-1 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1)
D: nknb (homo sapiens) (aka tachykinin precursor 3)
E: neuropeptide b... | [K; D; H] |
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical conce... | <Mentions>: [nk-3 receptor; neurokinin b; nka]
<Options>: A: nkb1b (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and long cytoplasmic tail 1)
B: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
C: neuromedin b (bos taurus) (aka neuromedin b)
D: nk3r (mus musculus) ... | [F; O; L] |
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical conce... | <Mentions>: [nk-3 receptor; neurokinin b; nka]
<Options>: A: nk2r (homo sapiens) (aka tachykinin receptor 2)
B: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
C: nkr-p1a (homo sapiens) (aka killer cell lectin like receptor b1)
D: nkna (homo sapiens) (aka tachykinin precursor 1)
E: nk-1 (homo sapiens) ... | [M; J; D] |
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical conce... | <Mentions>: [substance p]
<Options>: A: tachykinin precursor 3 (rattus norvegicus) (aka tachykinin precursor 3)
B: tachykinin precursor 1 (sus scrofa) (aka tachykinin precursor 1)
C: tachykinin precursor 1 (homo sapiens) (aka tachykinin precursor 1)
D: tachykinin precursor 4 (homo sapiens) (aka tachykinin precursor 4)
... | [C] |
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical conce... | <Mentions>: [substance p]
<Options>: A: tachykinin precursor 3 (rattus norvegicus) (aka tachykinin precursor 3)
B: nk-1 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1)
C: tachykinin precursor 4 (homo sapiens) (aka tachykinin precursor 4)
D: tachykinin precursor 1 (sus scrofa) (aka tachykinin precursor 1)
E: None ... | [E] |
<Instruct>: Given the context 'These results indicate that expression of the NK-3 receptor homolog cDNA in the Chinese hamster ovary cell system induces the expression of a receptor site with many similarities but certain key differences from that of the human NK-3 receptor.', select the correct biomedical concept for ... | <Mentions>: [nk-3 receptor]
<Options>: A: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
B: nkr (homo sapiens) (tachykinin receptor 3 (homo sapiens)) (aka tachykinin receptor 3)
C: nk3r (mus musculus) (aka tachykinin receptor 3)
D: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine ki... | [B] |
<Instruct>: Given the context 'Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-type natriuretic peptide]
<Options>: A: c-type natriuretic peptide 1 (gallus gallus) (aka c-type natriuretic peptide 1)
B: natriuretic peptide c (homo sapiens) (aka natriuretic peptide c)
C: natriuretic peptide c (rattus norvegicus) (aka natriuretic peptide c)
D: c-type natriuretic peptide-like (xenopus ... | [B] |
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