instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Unlike the other inhibitors, it is found almost exclusively in complexes containing RelA and/or cRel.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rela; crel]
<Options>: A: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
B: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
C: creld1 (oryctolagus c... | [D; K] |
<Instruct>: Given the context 'Unlike the other inhibitors, it is found almost exclusively in complexes containing RelA and/or cRel.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rela; crel]
<Options>: A: creld1 (oryctolagus cuniculus) (aka creld disulfide isomerase 1)
B: p65 (homo sapiens) (rela proto-oncogene, nf-kb subunit (homo sapiens)) (aka rela proto-oncogene, nf-kb subunit)
C: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
D: cati... | [B; K] |
<Instruct>: Given the context 'Upon activation, I kappa B-epsilon protein is degraded with slow kinetics by a proteasome-dependent mechanism.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b-epsilon]
<Options>: A: ikk-e (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
B: ikb-epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
C: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
D: nfkb... | [A] |
<Instruct>: Given the context 'Similarly to I kappa B-alpha', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b-alpha]
<Options>: A: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
B: ikk-alpha (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
C: nfkbia (homo sapiens) (aka nfkb inhibitor alpha)
D: nfkbib (homo sapiens) (aka nfkb inhibitor... | [C] |
<Instruct>: Given the context 'Similarly to I kappa B-alpha', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b-alpha]
<Options>: A: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
B: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
C: ikk-alpha (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
D: nfkbib (homo sapiens) (a... | [E] |
<Instruct>: Given the context 'and I kappa B, I kappa B-epsilon contains multiple ankyrin repeats and two conserved serines which are necessary for signal-induced degradation of the molecule.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [i kappa b-epsilon]
<Options>: A: inhibitor of kappab kinase epsilon (mus musculus) (aka inhibitor of kappab kinase epsilon)
B: ikk-e (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
C: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
D: nfkbie (homo sapiens) (aka nfkb ... | [B] |
<Instruct>: Given the context 'Unlike I kappa B- alpha and I kappa B-beta, I kappa B-epsilon does not contain a C-terminal PEST-like sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b- alpha; i kappa b-beta; i kappa b-epsilon]
<Options>: A: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
B: ikk-alpha (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
C: ikk-e (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subu... | [I; E; C] |
<Instruct>: Given the context 'Unlike I kappa B- alpha and I kappa B-beta, I kappa B-epsilon does not contain a C-terminal PEST-like sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b- alpha; i kappa b-beta; i kappa b-epsilon]
<Options>: A: nfkbi (homo sapiens) (aka nfkb inhibitor alpha)
B: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
C: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
D: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear ... | [A; I; K] |
<Instruct>: Given the context 'Unlike I kappa B- alpha and I kappa B-beta, I kappa B-epsilon does not contain a C-terminal PEST-like sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b- alpha; i kappa b-beta; i kappa b-epsilon]
<Options>: A: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
B: inhibitor of kappab kinase epsilon (mus musculus) (aka inhibitor of kappab kinase epsilon)
C: nfkbie (homo sapiens) (aka nfkb inhibitor epsilon)
D: ikba (homo sapiens) (aka nfkb inh... | [D; F; E] |
<Instruct>: Given the context 'Unlike I kappa B- alpha and I kappa B-beta, I kappa B-epsilon does not contain a C-terminal PEST-like sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b- alpha; i kappa b-beta; i kappa b-epsilon]
<Options>: A: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
B: nfkbie (homo sapiens) (aka nfkb inhibitor epsilon)
C: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
D: rela proto-oncogene, nf-kb subunit (homo sapiens) ... | [M; A; F] |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [i kappa b-epsilon; rela; crel; nf-kappa b]
<Options>: A: creld1 (oryctolagus cuniculus) (aka creld disulfide isomerase 1)
B: inhibitor of kappab kinase epsilon (mus musculus) (aka inhibitor of kappab kinase epsilon)
C: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, n... | [J; G; U; I] |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [i kappa b-epsilon; rela; crel; nf-kappa b]
<Options>: A: creg (homo sapiens) (aka cellular repressor of e1a stimulated genes 1)
B: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
C: nfkbie (homo sapiens) (aka nfkb inhibitor epsilon)
D: inhibitor of nuclear factor ... | [D; K; S; P] |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [i kappa b-epsilon; rela; crel; nf-kappa b]
<Options>: A: leucine--trna ligase, cytoplasmic-like (glycine max) (aka leucine--trna ligase, cytoplasmic-like)
B: nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon (xenopus tropicalis) (aka nuclear factor of kappa light polypep... | [O; R; T; F] |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [i kappa b-epsilon; rela; crel; nf-kappa b]
<Options>: A: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
B: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
C: i-kappa-b-zeta (homo sapiens) (aka nfkb ... | [N; L; T; O] |
<Instruct>: Given the context 'Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vps41]
<Options>: A: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
B: vps41 (drosophila melanogaster) (aka light)
C: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
D: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (ak... | [A] |
<Instruct>: Given the context 'Mutations in the yeast gene VPS41 give rise to poor growth on low iron medium, severe alterations in vacuolar morphology, and cause the missorting of membranous and soluble vacuolar proteins.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [vps41]
<Options>: A: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
B: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
C: vps41 (drosophila melanogaster) (aka light... | [E] |
<Instruct>: Given the context 'Our studies predict that VPS41 encodes a hydrophilic protein of 992 amino acids that contains no obvious signal sequence or hydrophobic domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [vps41]
<Options>: A: vps41 (drosophila melanogaster) (aka light)
B: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
C: vps41 (homo sapiens) (aka vps41 subunit of hops complex)
D: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
E: vacuolar protein sortin... | [B] |
<Instruct>: Given the context 'The deduced Vps41p sequence contains a domain rich in glutamic and aspartic residues, as well as a domain with resemblance to a region of clathrin heavy chain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [vps41p]
<Options>: A: vps41p (candida albicans sc5314) (aka vps41p)
B: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
C: atg41p (saccharomyces cerevisiae s288c) (aka atg41p)
D: vps41 (drosophila melanogaster) (aka light)
E: vomeronasal 1 receptor 41 pseudogene (homo sapiens) (aka vomeronasal 1 recept... | [B] |
<Instruct>: Given the context 'The deduced Vps41p sequence contains a domain rich in glutamic and aspartic residues, as well as a domain with resemblance to a region of clathrin heavy chain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [vps41p]
<Options>: A: vps41 (drosophila melanogaster) (aka light)
B: vomeronasal 1 receptor 41 pseudogene (homo sapiens) (aka vomeronasal 1 receptor 41 pseudogene)
C: atg41p (saccharomyces cerevisiae s288c) (aka atg41p)
D: vps41p (candida albicans sc5314) (aka vps41p)
E: None of the above. | [E] |
<Instruct>: Given the context 'The VPS41 homologues (but not the yeast VPS41 itself) contain a conserved cysteine-rich RING-H2 zinc finger at their COOH termini.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [vps41]
<Options>: A: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
B: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
C: vps41 (drosophila melanogaster) (aka light... | [D] |
<Instruct>: Given the context 'Biochemical experiments suggest that VPS41 functions in post-Golgi protein processing: the deletion mutant exhibits defective high affinity transport due to impaired Fet3p activity and also exhibits defects in the processing and sorting of multiple vacuolar hydrolases.', select the correc... | <Mentions>: [vps41; fet3p]
<Options>: A: vps41 (drosophila melanogaster) (aka light)
B: fet4p (saccharomyces cerevisiae s288c) (aka fet4p)
C: etf1p3 (homo sapiens) (aka eukaryotic translation termination factor 1 pseudogene 3)
D: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 ho... | [H; J] |
<Instruct>: Given the context 'Biochemical experiments suggest that VPS41 functions in post-Golgi protein processing: the deletion mutant exhibits defective high affinity transport due to impaired Fet3p activity and also exhibits defects in the processing and sorting of multiple vacuolar hydrolases.', select the correc... | <Mentions>: [vps41; fet3p]
<Options>: A: ferry endosomal rab5 effector complex subunit 3 (xenopus tropicalis) (aka ferry endosomal rab5 effector complex subunit 3)
B: hvsp41 (homo sapiens) (aka vps41 subunit of hops complex)
C: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homo... | [D; I] |
<Instruct>: Given the context 'Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [wnt7a]
<Options>: A: wnt7a (xenopus tropicalis) (aka wnt family member 7a)
B: wnt family member 7b (homo sapiens) (aka wnt family member 7b)
C: wnt7a (homo sapiens) (aka wnt family member 7a)
D: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenopus laevis)) (ak... | [C] |
<Instruct>: Given the context 'One mouse member, Wnt7a, is vital for limb development in vivo and also possesses transforming ability in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [wnt7a]
<Options>: A: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family member 7a s homeolog)
B: wnt family member 7a (xenopus tropicalis) (aka wnt family member 7a)
C: wnt-7a (homo sapiens) (aka wnt fam... | [C] |
<Instruct>: Given the context 'This study reports the isolation of a full length of human homologue of mouse Wnt7a gene by library screening.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [wnt7a]
<Options>: A: wnt family member 7a (homo sapiens) (aka wnt family member 7a)
B: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family, member 7c s homeolog)
C: wnt7a (xenopus tropicalis) (aka wnt f... | [A] |
<Instruct>: Given the context 'Yeast artificial chromosome-fluorescence in situ hybridisation (YAC-FISH) mapped the WNT7A gene to chromosome 3p25.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [wnt7a]
<Options>: A: wnt7a (xenopus tropicalis) (aka wnt family member 7a)
B: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family member 7a s homeolog)
C: wnt family member 7a (gallus gallus) (aka wnt fam... | [D] |
<Instruct>: Given the context 'Human WNT7A had an ORF encoding a deduced protein of 349 aa that exhibited 97% and 92% identity to mouse Wnt7a at the aa and nucleic acid levels, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [wnt7a]
<Options>: A: wnt7a (xenopus tropicalis) (aka wnt family member 7a)
B: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family member 7a s homeolog)
C: wnt7a (homo sapiens) (aka wnt family member 7a)
D... | [C] |
<Instruct>: Given the context 'Human WNT7A had an ORF encoding a deduced protein of 349 aa that exhibited 97% and 92% identity to mouse Wnt7a at the aa and nucleic acid levels, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [wnt7a]
<Options>: A: wnt7a (xenopus tropicalis) (aka wnt family member 7a)
B: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family, member 7c s homeolog)
C: wnt7a (gallus gallus) (aka wnt family member 7... | [E] |
<Instruct>: Given the context 'The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [smad7]
<Options>: A: smad7 (drosophila melanogaster) (aka daughters against dpp)
B: smad family member 5 (mus musculus) (aka smad family member 5)
C: smad (drosophila melanogaster) (mothers against dpp (drosophila melanogaster)) (aka mothers against dpp)
D: smad6 (homo sapiens) (aka smad family member 6)
E... | [E] |
<Instruct>: Given the context 'TGFbeta signaling is initiated when the type I receptor phosphorylates the MAD-related protein, Smad2, on C-terminal serine residues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [smad2]
<Options>: A: smad2/3 (drosophila melanogaster) (aka smad on x)
B: smad-2 (mus musculus) (aka smad family member 2)
C: smad family member 2 (homo sapiens) (aka smad family member 2)
D: None of the above. | [C] |
<Instruct>: Given the context 'This leads to Smad2 association with Smad4, translocation to the nucleus, and regulation of transcriptional responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad2; smad4]
<Options>: A: smad family member 2 (homo sapiens) (aka smad family member 2)
B: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
C: smad4 (drosophila melanogaster) (aka medea)
D: smad4 (homo sapiens) (aka smad family member 4)
E: mad4 (homo sapiens) (aka max dimerization p... | [A; D] |
<Instruct>: Given the context 'This leads to Smad2 association with Smad4, translocation to the nucleus, and regulation of transcriptional responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad2; smad4]
<Options>: A: smad family member 5 (homo sapiens) (aka smad family member 5)
B: smad2 (mus musculus) (aka smad family member 2)
C: smad2/3 (drosophila melanogaster) (aka smad on x)
D: madr2 (homo sapiens) (aka smad family member 2)
E: smad family member 4 (xenopus tropicalis) (aka smad family... | [D; H] |
<Instruct>: Given the context 'Here we demonstrate that Smad7 is an inhibitor of TGFbeta signaling.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7]
<Options>: A: smad family member 6 (mus musculus) (aka smad family member 6)
B: smad7 (drosophila melanogaster) (aka daughters against dpp)
C: smad (drosophila melanogaster) (mothers against dpp (drosophila melanogaster)) (aka mothers against dpp)
D: smad family member 7 (homo sapiens) (aka smad fam... | [D] |
<Instruct>: Given the context 'Smad7 prevents TGFbeta-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7; smad2; smad4]
<Options>: A: smad family member 6 (mus musculus) (aka smad family member 6)
B: smad family member 7 (homo sapiens) (aka smad family member 7)
C: smad2/3 (drosophila melanogaster) (aka smad on x)
D: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
E: smad4 (drosophi... | [B; F; H] |
<Instruct>: Given the context 'Smad7 prevents TGFbeta-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7; smad2; smad4]
<Options>: A: smad (drosophila melanogaster) (mothers against dpp (drosophila melanogaster)) (aka mothers against dpp)
B: smad family member 6 (mus musculus) (aka smad family member 6)
C: smad family member 4 (mus musculus) (aka smad family member 4)
D: smad family member 6 (homo sapie... | [K; M; L] |
<Instruct>: Given the context 'Smad7 prevents TGFbeta-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7; smad2; smad4]
<Options>: A: hsmad2 (homo sapiens) (smad family member 2 (homo sapiens)) (aka smad family member 2)
B: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
C: smad2/3 (drosophila melanogaster) (aka smad on x)
D: smad (drosophila melanogaster) (mothers against dpp (dros... | [H; A; M] |
<Instruct>: Given the context 'Smad7 prevents TGFbeta-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7; smad2; smad4]
<Options>: A: smad7 (drosophila melanogaster) (aka daughters against dpp)
B: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
C: smad family member 5 (homo sapiens) (aka smad family member 5)
D: smad4 (homo sapiens) (aka smad family member 4)
E: smad family member 5... | [F; H; D] |
<Instruct>: Given the context 'Smad7 interacts stably with the activated TGFbeta type I receptor, thereby blocking the association, phosphorylation, and activation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [smad7; tgfbeta type i receptor; smad2]
<Options>: A: smad (drosophila melanogaster) (mothers against dpp (drosophila melanogaster)) (aka mothers against dpp)
B: smad2 (drosophila melanogaster) (aka smad on x)
C: transforming growth factor beta receptor i (xenopus tropicalis) (aka transforming growth factor... | [G; I; F] |
<Instruct>: Given the context 'Smad7 interacts stably with the activated TGFbeta type I receptor, thereby blocking the association, phosphorylation, and activation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [smad7; tgfbeta type i receptor; smad2]
<Options>: A: smad2/3 (drosophila melanogaster) (aka smad on x)
B: madr2 (homo sapiens) (aka smad family member 2)
C: smad (drosophila melanogaster) (mothers against dpp (drosophila melanogaster)) (aka mothers against dpp)
D: transforming growth factor, beta receptor ... | [G; H; B] |
<Instruct>: Given the context 'Smad7 interacts stably with the activated TGFbeta type I receptor, thereby blocking the association, phosphorylation, and activation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [smad7; tgfbeta type i receptor; smad2]
<Options>: A: transforming growth factor beta receptor 1 (homo sapiens) (aka transforming growth factor beta receptor 1)
B: tgfbeta-rii (homo sapiens) (aka transforming growth factor beta receptor 2)
C: smad6 (homo sapiens) (aka smad family member 6)
D: transforming g... | [H; A; M] |
<Instruct>: Given the context 'Furthermore, mutations in Smad7 that interfere with receptor binding disrupt its inhibitory activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7]
<Options>: A: smad7 (drosophila melanogaster) (aka daughters against dpp)
B: smad7 (mus musculus) (aka smad family member 7)
C: smad family member 6 (mus musculus) (aka smad family member 6)
D: smad (drosophila melanogaster) (mothers against dpp (drosophila melanogaster)) (aka mothers against dpp)
E... | [E] |
<Instruct>: Given the context 'SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox22]
<Options>: A: sox21 (homo sapiens) (aka sry-box transcription factor 21)
B: sox2.s (xenopus laevis) (sry-box 2 s homeolog (xenopus laevis)) (aka sry-box 2 s homeolog)
C: sox22 (homo sapiens) (aka sry-box transcription factor 12)
D: transcription factor sox-2-like (homo sapiens) (aka transcription fa... | [C] |
<Instruct>: Given the context 'SOX (SRY box-containing) genes share a particular DNA-binding domain, called HMG, with the mammalian testis-determining gene SRY Several SOX genes have already been shown to be transcription factors involved in the decision of important cell fates during development.', select the correct ... | <Mentions>: [sry]
<Options>: A: sry (drosophila melanogaster) (sprouty (drosophila melanogaster)) (aka sprouty)
B: sex determining region y (sus scrofa) (aka sex determining region y)
C: sry-a (drosophila melanogaster) (aka serendipity alpha)
D: sry (xenopus tropicalis) (sry-box 3 (xenopus tropicalis)) (aka sry-box 3)
... | [E] |
<Instruct>: Given the context 'Here we report the cloning of a new human member of the SOX gene family, SOX22.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox22]
<Options>: A: sox28 (homo sapiens) (aka sry-box transcription factor 14)
B: sox20 (homo sapiens) (aka sry-box transcription factor 15)
C: sox22 (homo sapiens) (aka sry-box transcription factor 12)
D: sox2.s (xenopus laevis) (sry-box 2 s homeolog (xenopus laevis)) (aka sry-box 2 s homeolog)
E: sry-bo... | [C] |
<Instruct>: Given the context 'The SOX22 gene maps to chromosome 20 on band p13 and does not appear to be clustered with any other SOX gene mapped to date.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [sox22]
<Options>: A: sox22 (homo sapiens) (aka sry-box transcription factor 12)
B: sox28 (homo sapiens) (aka sry-box transcription factor 14)
C: sox2 (homo sapiens) (aka sry-box transcription factor 2)
D: sox20 (homo sapiens) (aka sry-box transcription factor 15)
E: sox21 (homo sapiens) (aka sry-box transc... | [A] |
<Instruct>: Given the context 'The SOX22 gene maps to chromosome 20 on band p13 and does not appear to be clustered with any other SOX gene mapped to date.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [sox22]
<Options>: A: sox21 (homo sapiens) (aka sry-box transcription factor 21)
B: sox20 (homo sapiens) (aka sry-box transcription factor 15)
C: sox2 (homo sapiens) (aka sry-box transcription factor 2)
D: sox28 (homo sapiens) (aka sry-box transcription factor 14)
E: None of the above. | [E] |
<Instruct>: Given the context 'SOX22 mRNA is expressed in various fetal and adult organs and tissues, suggesting that this gene plays roles in both differentiation and maintenance of several cell types.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [sox22]
<Options>: A: sry-box transcription factor 2 (homo sapiens) (aka sry-box transcription factor 2)
B: sox25 (homo sapiens) (aka sry-box transcription factor 21)
C: sox27 (homo sapiens) (aka sry-box transcription factor 15)
D: sox22 (homo sapiens) (aka sry-box transcription factor 12)
E: transcription ... | [D] |
<Instruct>: Given the context 'A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [retinal degeneration c; rdgc]
<Options>: A: rdgb1 (homo sapiens) (aka phosphatidylinositol transfer protein membrane associated 1)
B: retinal degeneration d (drosophila melanogaster) (aka retinal degeneration d)
C: retinal degeneration a (drosophila melanogaster) (aka retinal degeneration a)
D: rd3 (homo s... | [F; F] |
<Instruct>: Given the context 'A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [retinal degeneration c; rdgc]
<Options>: A: retinal degeneration a (drosophila melanogaster) (aka retinal degeneration a)
B: retinal degeneration c (drosophila melanogaster) (aka retinal degeneration c)
C: retinal degeneration g (drosophila melanogaster) (aka retinal degeneration g)
D: rdgb2 (homo sapiens)... | [B; B] |
<Instruct>: Given the context 'Through our transcriptional mapping effort in the Xp22 region, we have isolated by exon trapping a new transcript highly homologous to the Drosophila retinal degeneration C (rdgC) gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [retinal degeneration c; rdgc]
<Options>: A: retinal degeneration d (drosophila melanogaster) (aka retinal degeneration d)
B: retinal degeneration c (drosophila melanogaster) (aka retinal degeneration c)
C: retinal degeneration h (drosophila melanogaster) (aka retinal degeneration h)
D: retinal cone dystrop... | [B; B] |
<Instruct>: Given the context 'Through our transcriptional mapping effort in the Xp22 region, we have isolated by exon trapping a new transcript highly homologous to the Drosophila retinal degeneration C (rdgC) gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [retinal degeneration c; rdgc]
<Options>: A: rdgca (homo sapiens) (aka integral membrane protein 2b)
B: rdgb1 (homo sapiens) (aka phosphatidylinositol transfer protein membrane associated 1)
C: rdgb2 (homo sapiens) (aka phosphatidylinositol transfer protein membrane associated 2)
D: retinal degeneration c (... | [D; D] |
<Instruct>: Given the context 'rdgC encodes a serine/threonine phosphatase protein and is required in Drosophila to prevent light-induced retinal degeneration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [rdgc]
<Options>: A: rdgca (homo sapiens) (aka integral membrane protein 2b)
B: rdgc (drosophila melanogaster) (aka retinal degeneration c)
C: retgc (homo sapiens) (aka guanylate cyclase 2d, retinal)
D: rdgb2 (homo sapiens) (aka phosphatidylinositol transfer protein membrane associated 2)
E: rdgc (escherich... | [B] |
<Instruct>: Given the context 'rdgC encodes a serine/threonine phosphatase protein and is required in Drosophila to prevent light-induced retinal degeneration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [rdgc]
<Options>: A: retgc (homo sapiens) (aka guanylate cyclase 2d, retinal)
B: rdgc (escherichia coli str. k-12 substr. mg1655) (aka nucleoid-associated protein rdgc)
C: rdgca (homo sapiens) (aka integral membrane protein 2b)
D: rdgb2 (homo sapiens) (aka phosphatidylinositol transfer protein membrane asso... | [E] |
<Instruct>: Given the context 'This human gene is the first mammalian member of the serine-threonine phosphatase with EF hand motif gene family, and was thus named PPEF (Protein Phosphatase with EF calcium-binding domain).', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [ppef]
<Options>: A: epf (homo sapiens) (aka heat shock protein family e (hsp10) member 1)
B: ppef1 (xenopus tropicalis) (aka protein phosphatase, ef-hand calcium binding domain 1)
C: ppef-1 (mus musculus) (aka protein phosphatase with ef hand calcium-binding domain 1)
D: ppef (homo sapiens) (aka protein ph... | [D] |
<Instruct>: Given the context 'The expression pattern of the mouse Ppef gene was studied by RNA in situ hybridization on embryonic tissue sections.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ppef]
<Options>: A: ppef2 (xenopus tropicalis) (aka protein phosphatase, ef-hand calcium binding domain 2)
B: pedf (homo sapiens) (aka serpin family f member 1)
C: ppef1 (homo sapiens) (aka protein phosphatase with ef-hand domain 1)
D: ppef1 (xenopus tropicalis) (aka protein phosphatase, ef-hand calcium bi... | [E] |
<Instruct>: Given the context 'While rdgC is expressed in the visual system of the fly, as well as in the mushroom bodies of the central brain, we found that Ppef is highly expressed in sensory neurons of the dorsal root ganglia (DRG) and neural crest-derived cranial ganglia.', select the correct biomedical concept for... | <Mentions>: [rdgc; ppef]
<Options>: A: ppef (homo sapiens) (aka protein phosphatase with ef-hand domain 1)
B: rdgca (homo sapiens) (aka integral membrane protein 2b)
C: rdgc (drosophila melanogaster) (aka retinal degeneration c)
D: rdgc (escherichia coli str. k-12 substr. mg1655) (aka nucleoid-associated protein rdgc)
... | [C; I] |
<Instruct>: Given the context 'While rdgC is expressed in the visual system of the fly, as well as in the mushroom bodies of the central brain, we found that Ppef is highly expressed in sensory neurons of the dorsal root ganglia (DRG) and neural crest-derived cranial ganglia.', select the correct biomedical concept for... | <Mentions>: [rdgc; ppef]
<Options>: A: ppef-1 (mus musculus) (aka protein phosphatase with ef hand calcium-binding domain 1)
B: ppef1 (homo sapiens) (aka protein phosphatase with ef-hand domain 1)
C: rdgca (homo sapiens) (aka integral membrane protein 2b)
D: ppef1 (xenopus tropicalis) (aka protein phosphatase, ef-hand ... | [F; A] |
<Instruct>: Given the context 'The selective pattern of expression makes PPEF an important marker for sensory neuron differentiation and suggests a role for serine-threonine phosphatases in mammalian development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the ... | <Mentions>: [ppef]
<Options>: A: ppef2 (xenopus tropicalis) (aka protein phosphatase, ef-hand calcium binding domain 2)
B: ppef2 (homo sapiens) (aka protein phosphatase with ef-hand domain 2)
C: ppef1 (bos taurus) (aka protein phosphatase with ef-hand domain 1)
D: ppef1 (homo sapiens) (aka protein phosphatase with ef-h... | [D] |
<Instruct>: Given the context 'Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hogg1; ogg1]
<Options>: A: hogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
B: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
C: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
D: hgh1 (homo sapiens) (aka hgh1 cochaperone)
E: hoga1 (homo sapiens) (aka 4-hydroxy-2-oxogluta... | [G; K] |
<Instruct>: Given the context 'Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hogg1; ogg1]
<Options>: A: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
B: ogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
C: ogs1 (homo sapiens) (aka midline 1)
D: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
E: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glyc... | [B; I] |
<Instruct>: Given the context 'The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase activity that is a functional analog of the Fpg protein from Escherichia coli and excises 7,8-dihydro-8-oxoguanine (8-oxoG) from damaged DNA.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [ogg1; fpg]
<Options>: A: fpgs (drosophila melanogaster) (aka folylpolyglutamate synthase 1)
B: fpgt (xenopus tropicalis) (aka fucose-1-phosphate guanylyltransferase)
C: fpg2 (homo sapiens) (aka nei like dna glycosylase 3)
D: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
E: ogg1 (drosophila melan... | [K; J] |
<Instruct>: Given the context 'The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase activity that is a functional analog of the Fpg protein from Escherichia coli and excises 7,8-dihydro-8-oxoguanine (8-oxoG) from damaged DNA.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [ogg1; fpg]
<Options>: A: ogs1 (homo sapiens) (aka midline 1)
B: fpg-1 (arabidopsis thaliana) (aka mutm homolog-1)
C: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
D: fpgt (xenopus laevis) (aka fucose-1-phosphate guanylyltransferase l homeolog)
E: 8-oxoguanine dna glycosylase (oryctolagus cunicul... | [K; G] |
<Instruct>: Given the context 'This protein shares a 38% sequence identity with the yeast Ogg1 protein, adding this novel human gene product to the growing family of enzymes that the repair of oxidatively damaged bases and are related to the E. coli endonuclease III.', select the correct biomedical concept for each men... | <Mentions>: [ogg1; endonuclease iii]
<Options>: A: ogs1 (homo sapiens) (aka midline 1)
B: endonuclease iii (escherichia coli str. k-12 substr. mg1655) (aka endonuclease iii)
C: endo-i (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
D: ogg1 (drosophila melanoga... | [K; B] |
<Instruct>: Given the context 'This protein shares a 38% sequence identity with the yeast Ogg1 protein, adding this novel human gene product to the growing family of enzymes that the repair of oxidatively damaged bases and are related to the E. coli endonuclease III.', select the correct biomedical concept for each men... | <Mentions>: [ogg1; endonuclease iii]
<Options>: A: endonuclease iii homolog (caenorhabditis elegans) (aka endonuclease iii homolog)
B: ogs1 (homo sapiens) (aka midline 1)
C: endonuclease (saccharomyces cerevisiae s288c) (aka endonuclease)
D: cn-iii (homo sapiens) (aka 5'-nucleotidase, cytosolic iiia)
E: ogg1 (drosophil... | [K; H] |
<Instruct>: Given the context 'The cloned coding sequence was expressed in an E. coli strain that carried a disrupted fpg gene, the bacterial functional analog of OGG1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [fpg; ogg1]
<Options>: A: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
B: fpgt (xenopus laevis) (aka fucose-1-phosphate guanylyltransferase l homeolog)
C: fpgt (homo sapiens) (aka fucose-1-phosphate guanylyltransferase)
D: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dn... | [I; K] |
<Instruct>: Given the context 'The cloned coding sequence was expressed in an E. coli strain that carried a disrupted fpg gene, the bacterial functional analog of OGG1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [fpg; ogg1]
<Options>: A: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna lyase ogg1)
B: fpgs (homo sapiens) (aka folylpolyglutamate synthase)
C: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
D: fpg-1 (arabidopsis thaliana) (aka mutm homolog-1)
E: ogg1 (homo sapiens) (aka 8-oxog... | [F; K] |
<Instruct>: Given the context 'The products of the reaction are consistent with an enzymatic activity like the one displayed by the yeast Ogg1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ogg1]
<Options>: A: ogg1 (oryctolagus cuniculus) (aka 8-oxoguanine dna glycosylase)
B: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
C: ogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
D: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
E: ogs1 (homo sapiens) (aka midline ... | [F] |
<Instruct>: Given the context 'Moreover, when the human coding sequence was expressed in a yeast strain mutant in OGG1 it was able to complement the spontaneous mutator phenotype.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [ogg1]
<Options>: A: ogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
B: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
C: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna lyase ogg1)
D: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
E: ogs1 (homo sapiens)... | [F] |
<Instruct>: Given the context 'These results make this novel gene (hOGG1) a strong candidate for the human homolog of the yeast OGG1 and suggest an important role of its product in the protection of the genome from the mutagenic effects of the oxidatively damaged purines.', select the correct biomedical concept for eac... | <Mentions>: [hogg1; ogg1]
<Options>: A: ogs1 (homo sapiens) (aka midline 1)
B: hoga1 (homo sapiens) (aka 4-hydroxy-2-oxoglutarate aldolase 1)
C: hhg1 (homo sapiens) (aka sonic hedgehog signaling molecule)
D: ogg1 (oryctolagus cuniculus) (aka 8-oxoguanine dna glycosylase)
E: ogh1 (homo sapiens) (aka 8-oxoguanine dna gly... | [E; J] |
<Instruct>: Given the context 'These results make this novel gene (hOGG1) a strong candidate for the human homolog of the yeast OGG1 and suggest an important role of its product in the protection of the genome from the mutagenic effects of the oxidatively damaged purines.', select the correct biomedical concept for eac... | <Mentions>: [hogg1; ogg1]
<Options>: A: ogs1 (homo sapiens) (aka midline 1)
B: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna lyase ogg1)
C: homg1 (homo sapiens) (aka transient receptor potential cation channel subfamily m member 6)
D: hspg1 (homo sapiens) (aka syndecan 2)
E: ogg1 (drosophila melanog... | [F; I] |
<Instruct>: Given the context 'A minK-HERG complex regulates the cardiac potassium current I(Kr).
MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins.', select the correct biomedical concept for each mention using the ... | <Mentions>: [mink; herg]
<Options>: A: herg (homo sapiens) (aka potassium voltage-gated channel subfamily h member 2)
B: minp (homo sapiens) (aka bmerb domain containing 1)
C: kcnrg (homo sapiens) (aka potassium channel regulator)
D: min1 (homo sapiens) (aka cd59 molecule (cd59 blood group))
E: kcng (homo sapiens) (aka... | [H; A] |
<Instruct>: Given the context 'A minK-HERG complex regulates the cardiac potassium current I(Kr).
MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins.', select the correct biomedical concept for each mention using the ... | <Mentions>: [mink; herg]
<Options>: A: mink (homo sapiens) (potassium voltage-gated channel subfamily e regulatory subunit 1 (homo sapiens)) (aka potassium voltage-gated channel subfamily e regulatory subunit 1)
B: mink1 (mus musculus) (aka misshapen-like kinase 1 (zebrafish))
C: kcnrg (homo sapiens) (aka potassium cha... | [A; F] |
<Instruct>: Given the context 'MinK governs ion channel activation, regulation by second messengers, and the function and structure of the ion conduction pathway.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [mink]
<Options>: A: mink (homo sapiens) (potassium voltage-gated channel subfamily e regulatory subunit 1 (homo sapiens)) (aka potassium voltage-gated channel subfamily e regulatory subunit 1)
B: mink (drosophila melanogaster) (aka mitotic spindle and nuclear protein)
C: minp (homo sapiens) (aka bmerb doma... | [A] |
<Instruct>: Given the context 'Association of minK with a channel protein known as KvLQT1 produces a voltage-gated outward K+ current (I[sK]) resembling the slow cardiac repolarization current (I[Ks]).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [mink; kvlqt1]
<Options>: A: mink (homo sapiens) (potassium voltage-gated channel subfamily e regulatory subunit 1 (homo sapiens)) (aka potassium voltage-gated channel subfamily e regulatory subunit 1)
B: mink1 (homo sapiens) (aka misshapen like kinase 1)
C: mink (mus musculus) (potassium voltage-gated chan... | [A; I] |
<Instruct>: Given the context 'Association of minK with a channel protein known as KvLQT1 produces a voltage-gated outward K+ current (I[sK]) resembling the slow cardiac repolarization current (I[Ks]).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [mink; kvlqt1]
<Options>: A: kvlqt1 (xenopus tropicalis) (aka adp ribosylation factor gtpase activating protein 1)
B: mink (drosophila melanogaster) (aka mitotic spindle and nuclear protein)
C: potassium voltage-gated channel subfamily kqt member 1 (xenopus tropicalis) (aka potassium voltage-gated channel s... | [I; H] |
<Instruct>: Given the context 'HERG, a human homologue of the ether-a-go-go gene of the fruitfly Drosophila melanogaster, encodes a protein that produces the rapidly activating cardiac delayed rectifier (I[Kr]).', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [herg; ether-a-go-go]
<Options>: A: gok (homo sapiens) (aka stromal interaction molecule 1)
B: herg3 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 7)
C: ether a go-go (drosophila melanogaster) (aka ether a go-go)
D: herg (homo sapiens) (aka potassium voltage-gated channel subfamily ... | [D; C] |
<Instruct>: Given the context 'HERG, a human homologue of the ether-a-go-go gene of the fruitfly Drosophila melanogaster, encodes a protein that produces the rapidly activating cardiac delayed rectifier (I[Kr]).', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [herg; ether-a-go-go]
<Options>: A: ether a go-go (drosophila melanogaster) (aka ether a go-go)
B: girk1 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 3)
C: herg3 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 7)
D: go-alpha (drosophila melanogaster) (a... | [J; A] |
<Instruct>: Given the context 'HERG, a human homologue of the ether-a-go-go gene of the fruitfly Drosophila melanogaster, encodes a protein that produces the rapidly activating cardiac delayed rectifier (I[Kr]).', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [herg; ether-a-go-go]
<Options>: A: go (drosophila melanogaster) (gold tip (drosophila melanogaster)) (aka gold tip)
B: kcng (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 1)
C: go-alpha (drosophila melanogaster) (aka g protein alpha subunit o)
D: girk1 (homo sapiens) (aka p... | [J; G] |
<Instruct>: Given the context 'Although heterologously expressed HERG channels are largely indistinguishable from native cardiac I(Kr), a role for minK in this current is suggested by the diminished I(Kr) in an atrial tumour line subjected to minK antisense suppression.', select the correct biomedical concept for each ... | <Mentions>: [herg; mink]
<Options>: A: kcng (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 1)
B: mink (homo sapiens) (misshapen like kinase 1 (homo sapiens)) (aka misshapen like kinase 1)
C: mina (mus musculus) (aka ribosomal oxygenase 2)
D: mink (drosophila melanogaster) (aka mitotic s... | [G; F] |
<Instruct>: Given the context 'Although heterologously expressed HERG channels are largely indistinguishable from native cardiac I(Kr), a role for minK in this current is suggested by the diminished I(Kr) in an atrial tumour line subjected to minK antisense suppression.', select the correct biomedical concept for each ... | <Mentions>: [herg; mink]
<Options>: A: min (mus musculus) (aka apc, wnt signaling pathway regulator)
B: herg (homo sapiens) (aka potassium voltage-gated channel subfamily h member 2)
C: eag1 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 1)
D: mink (homo sapiens) (potassium voltage-gated channel... | [B; D] |
<Instruct>: Given the context 'Here we show that HERG and minK form a stable complex, and that this heteromultimerization regulates I(Kr) activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [herg; mink]
<Options>: A: mink (mus musculus) (potassium voltage-gated channel, isk-related subfamily, member 1 (mus musculus)) (aka potassium voltage-gated channel, isk-related subfamily, member 1)
B: mink1 (mus musculus) (aka misshapen-like kinase 1 (zebrafish))
C: herg-2 (homo sapiens) (aka potassium vo... | [G; E] |
<Instruct>: Given the context 'Here we show that HERG and minK form a stable complex, and that this heteromultimerization regulates I(Kr) activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [herg; mink]
<Options>: A: mink (homo sapiens) (potassium voltage-gated channel subfamily e regulatory subunit 1 (homo sapiens)) (aka potassium voltage-gated channel subfamily e regulatory subunit 1)
B: kcng (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 1)
C: mink (mus musc... | [E; A] |
<Instruct>: Given the context 'Here we show that HERG and minK form a stable complex, and that this heteromultimerization regulates I(Kr) activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [herg; mink]
<Options>: A: eag1 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 1)
B: mink (homo sapiens) (misshapen like kinase 1 (homo sapiens)) (aka misshapen like kinase 1)
C: herg1 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 2)
D: kcng (homo sapiens) (a... | [C; J] |
<Instruct>: Given the context 'MinK, through the formation of heteromeric channel complexes, is thus central to the control of the heart rate and rhythm.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [mink]
<Options>: A: minp (homo sapiens) (aka bmerb domain containing 1)
B: mink (mus musculus) (potassium voltage-gated channel, isk-related subfamily, member 1 (mus musculus)) (aka potassium voltage-gated channel, isk-related subfamily, member 1)
C: mina (mus musculus) (aka ribosomal oxygenase 2)
D: mink ... | [D] |
<Instruct>: Given the context 'X-linked IAP is a direct inhibitor of cell-death proteases.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [x-linked iap]
<Options>: A: c-iap1 (homo sapiens) (aka baculoviral iap repeat containing 2)
B: iap-1 (homo sapiens) (aka baculoviral iap repeat containing 3)
C: x-linked inhibitor of apoptosis (homo sapiens) (aka x-linked inhibitor of apoptosis)
D: ml-iap (xenopus laevis) (baculoviral iap repeat containing... | [C] |
<Instruct>: Given the context 'Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [x-chromosome-linked iap; caspase-3; caspase-7]
<Options>: A: caspase-7 (mus musculus) (aka caspase 7)
B: xxiap (xenopus laevis) (x-linked inhibitor of apoptosis s homeolog (xenopus laevis)) (aka x-linked inhibitor of apoptosis s homeolog)
C: xxiap (xenopus laevis) (x-linked inhibitor of apoptosis l homeolo... | [J; F; K] |
<Instruct>: Given the context 'Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [x-chromosome-linked iap; caspase-3; caspase-7]
<Options>: A: casp8 (homo sapiens) (aka caspase 8)
B: caspase 3 (homo sapiens) (aka caspase 3)
C: ice-lap3 (homo sapiens) (aka caspase 7)
D: caspase-3 (xenopus tropicalis) (aka caspase 3, gene 2)
E: baculoviral iap repeat-containing protein 1-like (xenopus lae... | [J; B; L] |
<Instruct>: Given the context 'Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [x-chromosome-linked iap; caspase-3; caspase-7]
<Options>: A: caspase 3 (homo sapiens) (aka caspase 3)
B: xxiap (xenopus laevis) (x-linked inhibitor of apoptosis s homeolog (xenopus laevis)) (aka x-linked inhibitor of apoptosis s homeolog)
C: caspase-7 (mus musculus) (aka caspase 7)
D: casp-3 (mus musculus)... | [M; A; I] |
<Instruct>: Given the context 'Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: fxr2 (homo sapiens) (aka fmr1 autosomal homolog 2)
B: fmr1 autosomal homolog 1 (homo sapiens) (aka fmr1 autosomal homolog 1)
C: fxr1-b (xenopus laevis) (fmr1 autosomal homolog 1 s homeolog (xenopus laevis)) (aka fmr1 autosomal homolog 1 s homeolog)
D: fmr1 autosomal homolog ... | [O; J; A] |
<Instruct>: Given the context 'Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: fxr1-b (xenopus laevis) (fmr1 autosomal homolog 1 s homeolog (xenopus laevis)) (aka fmr1 autosomal homolog 1 s homeolog)
B: nr1f2 (homo sapiens) (aka rar related orphan receptor b)
C: fxr (drosophila melanogaster) (fragile x messenger ribonucleoprotein 1 (drosophila melanoga... | [N; G; I] |
<Instruct>: Given the context 'Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: fmr1 autosomal homolog 2 (homo sapiens) (aka fmr1 autosomal homolog 2)
B: fxr (xenopus tropicalis) (aka nuclear receptor subfamily 1 group h member 4)
C: fxr (homo sapiens) (aka nuclear receptor subfamily 1 group h member 4)
D: fxr1 (xenopus tropicalis) (aka fmr1 autosomal h... | [M; L; A] |
<Instruct>: Given the context 'Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: fxr1 (xenopus tropicalis) (aka fmr1 autosomal homolog 1)
B: fmr1 autosomal homolog 2 (homo sapiens) (aka fmr1 autosomal homolog 2)
C: fmr1 autosomal homolog 1 (xenopus tropicalis) (frx1l (xenopus tropicalis)) (aka fmr1 autosomal homolog 1)
D: fxr (xenopus tropicalis) (aka nu... | [L; L; B] |
<Instruct>: Given the context 'Lack of expression of the fragile X mental retardation protein (FMRP) results in mental retardation and macroorchidism, seen as the major pathological symptoms in fragile X patients.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [fragile x mental retardation protein; fmrp]
<Options>: A: fmr1 autosomal homolog 1 (homo sapiens) (aka fmr1 autosomal homolog 1)
B: fmrp (homo sapiens) (aka fragile x messenger ribonucleoprotein 1)
C: fxr (drosophila melanogaster) (fragile x messenger ribonucleoprotein 1 (drosophila melanogaster)) (aka fra... | [B; B] |
<Instruct>: Given the context 'Lack of expression of the fragile X mental retardation protein (FMRP) results in mental retardation and macroorchidism, seen as the major pathological symptoms in fragile X patients.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [fragile x mental retardation protein; fmrp]
<Options>: A: fraxf (homo sapiens) (aka transmembrane protein 185a)
B: fmrp (mus musculus) (aka fragile x messenger ribonucleoprotein 1)
C: fmr1 autosomal homolog 1 (homo sapiens) (aka fmr1 autosomal homolog 1)
D: fmrp (xenopus tropicalis) (aka fragile x messenge... | [E; E] |
<Instruct>: Given the context 'FMRP is a cytoplasmic RNA-binding protein which cosediments with the 60S ribosomal subunit.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmrp]
<Options>: A: fmrp (drosophila melanogaster) (aka fragile x messenger ribonucleoprotein 1)
B: fmrp (mus musculus) (aka fragile x messenger ribonucleoprotein 1)
C: fmrp (homo sapiens) (aka fragile x messenger ribonucleoprotein 1)
D: fmr1 autosomal homolog 1 (homo sapiens) (aka fmr1 autosomal homolog 1... | [C] |
<Instruct>: Given the context 'Recently, two proteins homologous to FMRP were discovered: FXR1 and FXR2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmrp; fxr1; fxr2]
<Options>: A: fxr1 (xenopus tropicalis) (aka fmr1 autosomal homolog 1)
B: fxr2 (homo sapiens) (aka fmr1 autosomal homolog 2)
C: fxr (drosophila melanogaster) (fragile x messenger ribonucleoprotein 1 (drosophila melanogaster)) (aka fragile x messenger ribonucleoprotein 1)
D: fmrp (xenopus ... | [K; I; B] |
<Instruct>: Given the context 'Recently, two proteins homologous to FMRP were discovered: FXR1 and FXR2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmrp; fxr1; fxr2]
<Options>: A: fxr2 (homo sapiens) (aka fmr1 autosomal homolog 2)
B: fxr1-a (xenopus laevis) (fmr1 autosomal homolog 1 l homeolog (xenopus laevis)) (aka fmr1 autosomal homolog 1 l homeolog)
C: fxr (xenopus tropicalis) (aka nuclear receptor subfamily 1 group h member 4)
D: nr1f2 (homo sapie... | [L; J; A] |
<Instruct>: Given the context 'Recently, two proteins homologous to FMRP were discovered: FXR1 and FXR2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmrp; fxr1; fxr2]
<Options>: A: fmr1 autosomal homolog 1 (homo sapiens) (aka fmr1 autosomal homolog 1)
B: fragile x messenger ribonucleoprotein 1 (drosophila melanogaster) (aka fragile x messenger ribonucleoprotein 1)
C: fmr1 (homo sapiens) (fragile x messenger ribonucleoprotein 1 (homo sapiens)) (aka frag... | [C; I; G] |
<Instruct>: Given the context 'These novel proteins interact with FMRP and with each other and they are also associated with the 60S ribosomal subunit.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [fmrp]
<Options>: A: fmr1 autosomal homolog 1 (mus musculus) (aka fmr1 autosomal homolog 1)
B: fmrp (mus musculus) (aka fragile x messenger ribonucleoprotein 1)
C: fmr1 (homo sapiens) (fragile x messenger ribonucleoprotein 1 (homo sapiens)) (aka fragile x messenger ribonucleoprotein 1)
D: fragile x messenge... | [C] |
<Instruct>: Given the context 'In adult brain, FMR1, FXR1 and FXR2 proteins are coexpressed in the cytoplasm of specific differentiated neurons only.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: xfxr1 (xenopus laevis) (fmr1 autosomal homolog 1 s homeolog (xenopus laevis)) (aka fmr1 autosomal homolog 1 s homeolog)
B: fmr1 (homo sapiens) (fragile site, folic acid type, rare, fra(x)(q27.3) a (homo sapiens)) (aka fragile site, folic acid type, rare, fra(x)(q27.3) a)
C: ... | [O; H; F] |
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