instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'A significant identity for hRL14 was observed with rat RL14 (85% identity), with exception of COOH-terminal region, but not with any eukaryote amino acid sequences so far deposited to database.', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [hrl14; rl14]
<Options>: A: rl14 (homo sapiens) (aka ribosomal protein l14)
B: hmgb1l14 (homo sapiens) (aka high mobility group box 1 pseudogene 14)
C: ribosomal rna-processing protein 14-c-like (glycine max) (aka ribosomal rna-processing protein 14-c-like)
D: rpl14l (homo sapiens) (aka ribosomal protein l1... | [A; K] |
<Instruct>: Given the context 'A significant identity for hRL14 was observed with rat RL14 (85% identity), with exception of COOH-terminal region, but not with any eukaryote amino acid sequences so far deposited to database.', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [hrl14; rl14]
<Options>: A: rab14, member ras oncogene family l homeolog (xenopus laevis) (aka rab14, member ras oncogene family l homeolog)
B: arl14 (homo sapiens) (aka arf like gtpase 14)
C: cluster homolog of immunoglobin like receptor like 14 (gallus gallus) (aka cluster homolog of immunoglobin like rec... | [E; K] |
<Instruct>: Given the context 'The typical features of ribosomal proteins were observed in hRL14, as seen in nuclear targeting sequences necessary for the transport from cytoplasm to nucleolus, a bZIP like (basic region-leucine zipper) element for the binding to rRNA, and the internal repeat sequences; the pentapeptide... | <Mentions>: [hrl14]
<Options>: A: rpl14l (homo sapiens) (aka ribosomal protein l14 pseudogene 1)
B: hmgb1l14 (homo sapiens) (aka high mobility group box 1 pseudogene 14)
C: arl14 (homo sapiens) (aka arf like gtpase 14)
D: hrl14 (homo sapiens) (aka ribosomal protein l14)
E: ribosomal protein l24-like (drosophila melanog... | [D] |
<Instruct>: Given the context 'The COOH-terminal region of the transcripts contained fifteen triplet repeats (GCT; alanine) at nucleotide 465 to 509, which is significantly expanded compared to the rat RL14.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [rl14]
<Options>: A: rpl14 (drosophila melanogaster) (aka ribosomal protein l14)
B: rl14 (homo sapiens) (aka ribosomal protein l14)
C: rab14, member ras oncogene family l homeolog (xenopus laevis) (aka rab14, member ras oncogene family l homeolog)
D: ribosomal rna-processing protein 14-c-like (glycine max) ... | [F] |
<Instruct>: Given the context 'Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation.
D-Dopachrome tautomerase converts 2-carboxy-2,3-dihydroindole-5,6-quinone (D-dopachrome) into 5,6-dihydroxyindole.', select the correct biomedical concept for each mention usin... | <Mentions>: [d-dopachrome tautomerase]
<Options>: A: d-dopachrome tautomerase (xenopus tropicalis) (aka d-dopachrome tautomerase)
B: d-dopachrome tautomerase (bos taurus) (aka d-dopachrome tautomerase)
C: d-dopachrome tautomerase (mus musculus) (aka d-dopachrome tautomerase)
D: d-dopachrome tautomerase (homo sapiens) (... | [D] |
<Instruct>: Given the context 'This protein has an amino acid sequence that is highly homologous with that of macrophage migration inhibitory factor (MIF), which has the potential to catalyze D-dopachrome to 5,6-dihydroxyindole-2-carboxylic acid and is an important cytokine for T-lymphocyte activation.', select the cor... | <Mentions>: [macrophage migration inhibitory factor; mif]
<Options>: A: macrophage migration inhibitory factor (caenorhabditis elegans) (aka macrophage migration inhibitory factor)
B: mif (mus musculus) (aka macrophage migration inhibitory factor (glycosylation-inhibiting factor))
C: macrophage migration inhibitory fac... | [C; C] |
<Instruct>: Given the context 'This protein has an amino acid sequence that is highly homologous with that of macrophage migration inhibitory factor (MIF), which has the potential to catalyze D-dopachrome to 5,6-dihydroxyindole-2-carboxylic acid and is an important cytokine for T-lymphocyte activation.', select the cor... | <Mentions>: [macrophage migration inhibitory factor; mif]
<Options>: A: mif1 (homo sapiens) (aka homocysteine inducible er protein with ubiquitin like domain 1)
B: migration and invasion inhibitory protein (homo sapiens) (aka migration and invasion inhibitory protein)
C: mif-2 (homo sapiens) (aka d-dopachrome tautomera... | [G; G] |
<Instruct>: Given the context 'We isolated and sequenced a 566 bp-long cDNA encoding human D-dopachrome tautomerase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [d-dopachrome tautomerase]
<Options>: A: d-dopachrome tautomerase (homo sapiens) (aka d-dopachrome tautomerase)
B: dopachrome tautomerase (mus musculus) (aka dopachrome tautomerase)
C: dopachrome tautomerase (homo sapiens) (aka dopachrome tautomerase)
D: dopachrome tautomerase (bos taurus) (aka dopachrome t... | [A] |
<Instruct>: Given the context 'Northern blot analysis demonstrated that mRNA of D-dopachrome tautomerase is expressed in a large amount in the liver, and to lesser extent in other organs, including the heart, lung and pancreas.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [d-dopachrome tautomerase]
<Options>: A: d-dopachrome tautomerase (homo sapiens) (aka d-dopachrome tautomerase)
B: dopachrome tautomerase (homo sapiens) (aka dopachrome tautomerase)
C: dopachrome tautomerase (xenopus tropicalis) (aka dopachrome tautomerase)
D: dopachrome tautomerase (bos taurus) (aka dopach... | [A] |
<Instruct>: Given the context 'After purification of D-dopachrome tautomerase expressed in E. coli, we confirmed that the recombinant protein catalyzes the conversion of D-dopachrome to 5,6-dihydroxyindole.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [d-dopachrome tautomerase]
<Options>: A: dopachrome tautomerase (bos taurus) (aka dopachrome tautomerase)
B: d-dopachrome tautomerase (bos taurus) (aka d-dopachrome tautomerase)
C: d-dopachrome tautomerase (xenopus tropicalis) (aka d-dopachrome tautomerase)
D: dopachrome tautomerase (xenopus tropicalis) (ak... | [E] |
<Instruct>: Given the context 'Although the precise pathophysiological function of D-dopachrome tautomerase remains to be elucidated, the present results could contribute to further understanding of isomerase activity in relation to the immune response.', select the correct biomedical concept for each mention using the... | <Mentions>: [d-dopachrome tautomerase]
<Options>: A: dopachrome tautomerase (xenopus tropicalis) (aka dopachrome tautomerase)
B: d-dopachrome tautomerase (homo sapiens) (aka d-dopachrome tautomerase)
C: dopachrome tautomerase (mus musculus) (aka dopachrome tautomerase)
D: d-dopachrome tautomerase (mus musculus) (aka d-... | [B] |
<Instruct>: Given the context 'Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pax4]
<Options>: A: paired box 4 (bos taurus) (aka paired box 4)
B: pax-4 (mus musculus) (aka paired box 4)
C: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
D: paired box 4 (homo sapiens) (aka paired box 4)
E: pax4 (xenopus tropicalis) (aka paired box 4)
F: None of the above. | [B] |
<Instruct>: Given the context 'Recent genetic studies have suggested that PAX4, a member of the paired box (PAX) gene family, is involved in the mechanism regulating the fate of pancreatic islet endocrine progenitor cells.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [pax4]
<Options>: A: pax-4 (mus musculus) (aka paired box 4)
B: paired box 4 (gallus gallus) (aka paired box 4)
C: pax4 (homo sapiens) (aka paired box 4)
D: paired box 4 (bos taurus) (aka paired box 4)
E: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
F: None of the above. | [A] |
<Instruct>: Given the context 'Murine PAX4 was originally identified by genomic screening and, to date, only a partial sequence of PAX4 has been reported.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [pax4]
<Options>: A: paired box 4 (xenopus tropicalis) (aka paired box 4)
B: paired box 4 (homo sapiens) (aka paired box 4)
C: pax4 (mus musculus) (aka paired box 4)
D: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
E: paired box 4 (bos taurus) (aka paired box 4)
F: None of the abo... | [C] |
<Instruct>: Given the context 'Murine PAX4 was originally identified by genomic screening and, to date, only a partial sequence of PAX4 has been reported.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [pax4]
<Options>: A: paired box 4 (xenopus tropicalis) (aka paired box 4)
B: paired box 4 (homo sapiens) (aka paired box 4)
C: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
D: paired box 4 (bos taurus) (aka paired box 4)
E: None of the above. | [E] |
<Instruct>: Given the context 'In this study, we cloned the full-length cDNA of mouse PAX4 by RACE (rapid amplification of cDNA ends) using RNA from MIN6 cells, a mouse insulinoma cell line.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [pax4]
<Options>: A: pax-4 (xenopus tropicalis) (aka paired box 4)
B: pax4 (mus musculus) (aka paired box 4)
C: paired box 4 (homo sapiens) (aka paired box 4)
D: paired box 4 (bos taurus) (aka paired box 4)
E: paired box 4 (gallus gallus) (aka paired box 4)
F: None of the above. | [B] |
<Instruct>: Given the context 'The deduced mouse PAX4 protein was 349 amino acids and had the predicted molecular weight of 38 kDa.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pax4]
<Options>: A: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
B: paired box 4 (bos taurus) (aka paired box 4)
C: pax-4 (mus musculus) (aka paired box 4)
D: pax4 (xenopus tropicalis) (aka paired box 4)
E: paired box 4 (gallus gallus) (aka paired box 4)
F: None of the above. | [C] |
<Instruct>: Given the context 'Two DNA binding motifs, a 128-amino acid paired domain and a 61-amino acid paired-type homeodomain exhibit the highest amino acid homology with PAX6 (71.2%, 65.0%, respectively), another member of the PAX gene family.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [pax6]
<Options>: A: paired box 6 (homo sapiens) (aka paired box 6)
B: paired box protein 6 homolog (gallus gallus) (aka paired box protein 6 homolog)
C: paired box 6 like (xenopus tropicalis) (aka paired box 6 like)
D: paired box protein 6 homolog (caenorhabditis elegans) (aka paired box protein 6 homolog)... | [A] |
<Instruct>: Given the context 'However, the sequence of the C-terminal segment of PAX4 diverged and showed no significant homology with any other known PAX genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [pax4]
<Options>: A: pax-4 (xenopus tropicalis) (aka paired box 4)
B: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
C: pax-4 (mus musculus) (aka paired box 4)
D: pax4 (homo sapiens) (aka paired box 4)
E: paired box 4 (gallus gallus) (aka paired box 4)
F: None of the above. | [C] |
<Instruct>: Given the context 'As to the genomic DNA, the coding region of the mouse PAX4 gene spanned approximately 5.5 kb and was composed of 10 exons.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [pax4]
<Options>: A: pax-4 (xenopus tropicalis) (aka paired box 4)
B: pax4 (homo sapiens) (aka paired box 4)
C: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
D: pax-4 (mus musculus) (aka paired box 4)
E: paired box 4 (bos taurus) (aka paired box 4)
F: None of the above. | [D] |
<Instruct>: Given the context 'In the public DNA database, a human cosmid (g1572c264), which was localized on human chromosome 7q31.3, was found to contain a gene homologous to PAX4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [pax4]
<Options>: A: pax-4 (xenopus tropicalis) (aka paired box 4)
B: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
C: pax4 (homo sapiens) (aka paired box 4)
D: paired box 4 (gallus gallus) (aka paired box 4)
E: paired box 4 (bos taurus) (aka paired box 4)
F: None of the above. | [C] |
<Instruct>: Given the context 'The nucleotide and protein sequence homologies between mouse PAX4 and its human homologue were 83.1% and 80.0%, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [pax4]
<Options>: A: pax4 (homo sapiens) (aka paired box 4)
B: pax4 (xenopus tropicalis) (aka paired box 4)
C: pax4 (mus musculus) (aka paired box 4)
D: paired box 4 (gallus gallus) (aka paired box 4)
E: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
F: None of the above. | [C] |
<Instruct>: Given the context 'Interestingly, the ARP5 (ADP-ribosylation factor 5) gene was also found in the same cosmid g1572c264, suggesting the ARP5 gene to be adjacent to the human PAX4 homologue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [arp5; adp-ribosylation factor 5; pax4]
<Options>: A: adp-ribosylation factor-like 5 (drosophila melanogaster) (aka adp-ribosylation factor-like 5)
B: adp ribosylation factor 5 (sus scrofa) (aka adp ribosylation factor 5)
C: actin related protein 5 (homo sapiens) (aka actin related protein 5)
D: pax4 (xenop... | [J; J; H] |
<Instruct>: Given the context 'Interestingly, the ARP5 (ADP-ribosylation factor 5) gene was also found in the same cosmid g1572c264, suggesting the ARP5 gene to be adjacent to the human PAX4 homologue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [arp5; adp-ribosylation factor 5; pax4]
<Options>: A: pax4 (xenopus tropicalis) (aka paired box 4)
B: arf-5 (caenorhabditis elegans) (aka adp-ribosylation factor)
C: adp ribosylation factor 5 (sus scrofa) (aka adp ribosylation factor 5)
D: arf gtpase 5 (homo sapiens) (aka arf gtpase 5)
E: paired box 4 (gall... | [D; D; O] |
<Instruct>: Given the context 'Interestingly, the ARP5 (ADP-ribosylation factor 5) gene was also found in the same cosmid g1572c264, suggesting the ARP5 gene to be adjacent to the human PAX4 homologue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [arp5; adp-ribosylation factor 5; pax4]
<Options>: A: paired box 4 (bos taurus) (aka paired box 4)
B: arp5 actin related protein 5 homolog (xenopus tropicalis) (aka arp5 actin related protein 5 homolog)
C: pax4 (mus musculus) (aka paired box 4)
D: arp5 actin-related protein 5 homolog (gallus gallus) (aka ar... | [L; L; H] |
<Instruct>: Given the context 'Interestingly, the ARP5 (ADP-ribosylation factor 5) gene was also found in the same cosmid g1572c264, suggesting the ARP5 gene to be adjacent to the human PAX4 homologue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [arp5; adp-ribosylation factor 5; pax4]
<Options>: A: pax-4 (mus musculus) (aka paired box 4)
B: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
C: pax4 (homo sapiens) (aka paired box 4)
D: arf5 (homo sapiens) (aka arf gtpase 5)
E: arl5ap5 (homo sapiens) (aka arl5a pseudogene 5)
F: ... | [D; D; C] |
<Instruct>: Given the context 'The results of this study, i.e. isolation of the full-length cDNA sequence of PAX4 and identification of the homologous human gene, will facilitate further functional and genetic studies of the PAX4 gene.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [pax4]
<Options>: A: pax4 (homo sapiens) (aka paired box 4)
B: pax4 (mus musculus) (aka paired box 4)
C: paired box 4 (bos taurus) (aka paired box 4)
D: pax-4 (xenopus tropicalis) (aka paired box 4)
E: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
F: None of the above. | [B] |
<Instruct>: Given the context 'Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [gsta3; gsta4; gsta4-4]
<Options>: A: gsta4-ps4 (rattus norvegicus) (aka glutathione s-transferase alpha 4, pseudogene 4)
B: gstm4 (homo sapiens) (aka glutathione s-transferase mu 4)
C: gsta4-4 (homo sapiens) (aka glutathione s-transferase alpha 4)
D: gsta3l (gallus gallus) (aka glutathione s-transferase al... | [M; C; C] |
<Instruct>: Given the context 'Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [gsta3; gsta4; gsta4-4]
<Options>: A: gsta4p (homo sapiens) (aka glutathione s-transferase alpha 9, pseudogene)
B: gsta4 (sus scrofa) (aka glutathione s-transferase alpha 4)
C: gsta4 (gallus gallus) (aka glutathione s-transferase alpha 4)
D: gsta4-4 (xenopus laevis) (aka glutathione s-transferase alpha 4 s ... | [N; I; I] |
<Instruct>: Given the context 'Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [gsta3; gsta4; gsta4-4]
<Options>: A: gstm3p (homo sapiens) (aka glutathione s-transferase mu 3 pseudogene 1)
B: gsta4 (sus scrofa) (aka glutathione s-transferase alpha 4)
C: gstm3 (homo sapiens) (aka glutathione s-transferase mu 3)
D: gstap4 (homo sapiens) (aka glutathione s-transferase alpha 9, pseudogene... | [G; M; M] |
<Instruct>: Given the context 'Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [gsta3; gsta4; gsta4-4]
<Options>: A: glutathione s-transferase alpha 3 (homo sapiens) (aka glutathione s-transferase alpha 3)
B: gst-iii (homo sapiens) (aka microsomal glutathione s-transferase 3)
C: gsta3 (gallus gallus) (aka glutathione s-transferase alpha 3)
D: gst4 (homo sapiens) (aka glutathione s-tra... | [A; F; F] |
<Instruct>: Given the context 'An incomplete transcript of the previously described GSTA3 gene was identified in a cDNA library derived from 8-9 week placenta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [gsta3]
<Options>: A: gstm3p (homo sapiens) (aka glutathione s-transferase mu 3 pseudogene 1)
B: gst-3 (homo sapiens) (aka microsomal glutathione s-transferase 3)
C: gstm3 (homo sapiens) (aka glutathione s-transferase mu 3)
D: gsta3-3 (homo sapiens) (aka glutathione s-transferase alpha 3)
E: gsta3l (gallus ... | [D] |
<Instruct>: Given the context 'This indicates that the GSTA3 gene is functional and is possibly under specific developmental regulation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gsta3]
<Options>: A: gstm3p (homo sapiens) (aka glutathione s-transferase mu 3 pseudogene 1)
B: gsta3-3 (homo sapiens) (aka glutathione s-transferase alpha 3)
C: gsta3l (gallus gallus) (aka glutathione s-transferase alpha 4)
D: gstm3 (homo sapiens) (aka glutathione s-transferase mu 3)
E: gstap3 (homo sapie... | [B] |
<Instruct>: Given the context 'A second cDNA, termed GSTA4, was identified in a brain cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gsta4]
<Options>: A: gsta4 (gallus gallus) (aka glutathione s-transferase alpha 4)
B: gstm4 (homo sapiens) (aka glutathione s-transferase mu 4)
C: gstap4 (homo sapiens) (aka glutathione s-transferase alpha 9, pseudogene)
D: gst4 (homo sapiens) (aka glutathione s-transferase mu 2)
E: gsta4 (homo sapiens) (a... | [E] |
<Instruct>: Given the context 'The encoded GSTA4-4 enzyme was expressed in Escherichia coli and was found to be immunologically distinct from GSTA1-1 and to have high activity with alk-2-enals.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [gsta4-4; gsta1-1]
<Options>: A: gsta11p (homo sapiens) (aka glutathione s-transferase alpha 11, pseudogene)
B: gsta4-ps4 (rattus norvegicus) (aka glutathione s-transferase alpha 4, pseudogene 4)
C: gst-1 (homo sapiens) (aka carbohydrate sulfotransferase 1)
D: gsta4 (homo sapiens) (aka glutathione s-transfe... | [D; H] |
<Instruct>: Given the context 'The encoded GSTA4-4 enzyme was expressed in Escherichia coli and was found to be immunologically distinct from GSTA1-1 and to have high activity with alk-2-enals.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [gsta4-4; gsta1-1]
<Options>: A: gsta11p (homo sapiens) (aka glutathione s-transferase alpha 11, pseudogene)
B: gsta4-4 (xenopus laevis) (aka glutathione s-transferase alpha 4 s homeolog)
C: gsta4-4 (xenopus tropicalis) (aka glutathione s-transferase alpha 4)
D: gsta1-1 (sus scrofa) (aka glutathione s-trans... | [H; I] |
<Instruct>: Given the context 'Although GSTA4-4 appears to be functionally similar to the mouse GST5.7 and rat GST8-8 Alpha class enzymes, sequence comparisons and phylogenetic analysis suggest that GSTA4-4 may be a member of a distinct Alpha class subgroup.', select the correct biomedical concept for each mention usin... | <Mentions>: [gsta4-4; gst5.7; gst8-8 alpha]
<Options>: A: gsta4-ps4 (rattus norvegicus) (aka glutathione s-transferase alpha 4, pseudogene 4)
B: gsta7p (homo sapiens) (aka glutathione s-transferase alpha 7, pseudogene)
C: gstf8 (glycine max) (aka glutathione s-transferase f11-like)
D: glutathione s-transferase gst 8 (g... | [F; H; O] |
<Instruct>: Given the context 'Although GSTA4-4 appears to be functionally similar to the mouse GST5.7 and rat GST8-8 Alpha class enzymes, sequence comparisons and phylogenetic analysis suggest that GSTA4-4 may be a member of a distinct Alpha class subgroup.', select the correct biomedical concept for each mention usin... | <Mentions>: [gsta4-4; gst5.7; gst8-8 alpha]
<Options>: A: glutathione s-transferase gst 8 (glycine max) (aka glutathione s-transferase gst 8)
B: gst-5 (homo sapiens) (aka carbohydrate sulfotransferase 7)
C: gsta4-4 (xenopus laevis) (aka glutathione s-transferase alpha 4 s homeolog)
D: gstf8 (glycine max) (aka glutathio... | [I; K; M] |
<Instruct>: Given the context 'Although GSTA4-4 appears to be functionally similar to the mouse GST5.7 and rat GST8-8 Alpha class enzymes, sequence comparisons and phylogenetic analysis suggest that GSTA4-4 may be a member of a distinct Alpha class subgroup.', select the correct biomedical concept for each mention usin... | <Mentions>: [gsta4-4; gst5.7; gst8-8 alpha]
<Options>: A: gstl5 (glycine max) (aka glutathione s-transferase l3)
B: gsta4-4 (xenopus laevis) (aka glutathione s-transferase alpha 4 s homeolog)
C: gstm5-5 (homo sapiens) (aka glutathione s-transferase mu 5)
D: gsta4 (homo sapiens) (aka glutathione s-transferase alpha 4)
E... | [D; I; N] |
<Instruct>: Given the context 'Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [actinin-4]
<Options>: A: actinin alpha 4 (homo sapiens) (aka actinin alpha 4)
B: actn4 (mus musculus) (aka actinin alpha 4)
C: actn4.l (xenopus laevis) (actinin alpha 4 s homeolog (xenopus laevis)) (aka actinin alpha 4 s homeolog)
D: actinin alpha 4 (xenopus tropicalis) (aka actinin alpha 4)
E: actin;actin... | [A] |
<Instruct>: Given the context 'This isoform (designated actinin-4) was concentrated in the cytoplasm where cells were sharply extended and in cells migrating and located at the edge of cell clusters, but was absent from focal adhesion plaques or adherens junctions, where the classic isoform (actinin-1) was concentrated... | <Mentions>: [actinin-4; actinin-1]
<Options>: A: actinin alpha 2 (homo sapiens) (aka actinin alpha 2)
B: actinin alpha 1 (homo sapiens) (aka actinin alpha 1)
C: actinin-4 (homo sapiens) (aka actinin alpha 4)
D: actin;actin-4 (caenorhabditis elegans) (aka actin;actin-4)
E: actn4.l (xenopus laevis) (actinin alpha 4 l hom... | [C; B] |
<Instruct>: Given the context 'This isoform (designated actinin-4) was concentrated in the cytoplasm where cells were sharply extended and in cells migrating and located at the edge of cell clusters, but was absent from focal adhesion plaques or adherens junctions, where the classic isoform (actinin-1) was concentrated... | <Mentions>: [actinin-4; actinin-1]
<Options>: A: actn1 (homo sapiens) (aka actinin alpha 1)
B: actn4.l (xenopus laevis) (actinin alpha 4 l homeolog (xenopus laevis)) (aka actinin alpha 4 l homeolog)
C: actinin alpha 2 (homo sapiens) (aka actinin alpha 2)
D: actinin alpha 4 (xenopus tropicalis) (aka actinin alpha 4)
E: ... | [F; A] |
<Instruct>: Given the context 'Actinin-4 shifted steadily from the cytoplasm to the nucleus upon inhibition of phosphatidylinositol 3 kinase or actin depolymerization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [actinin-4]
<Options>: A: actn4.l (xenopus laevis) (actinin alpha 4 l homeolog (xenopus laevis)) (aka actinin alpha 4 l homeolog)
B: actinin alpha 4 (xenopus tropicalis) (aka actinin alpha 4)
C: actinin alpha 4 (mus musculus) (aka actinin alpha 4)
D: actn4 (homo sapiens) (aka actinin alpha 4)
E: actn4.l (xe... | [D] |
<Instruct>: Given the context 'The cytoplasmic localization of actinin-4 was closely associated with an infiltrative histological phenotype and correlated significantly with a poorer prognosis in 61 cases of breast cancer.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [actinin-4]
<Options>: A: actinin alpha 4 (mus musculus) (aka actinin alpha 4)
B: actn4.l (xenopus laevis) (actinin alpha 4 l homeolog (xenopus laevis)) (aka actinin alpha 4 l homeolog)
C: actinin alpha 4 (homo sapiens) (aka actinin alpha 4)
D: actinin alpha 4 (bos taurus) (aka actinin alpha 4)
E: actinin a... | [C] |
<Instruct>: Given the context 'These findings suggest that cytoplasmic actinin-4 regulates the actin cytoskeleton and increases cellular motility and that its inactivation by transfer to the nucleus abolishes the metastatic potential of human cancers.', select the correct biomedical concept for each mention using the p... | <Mentions>: [actinin-4]
<Options>: A: actn4.l (xenopus laevis) (actinin alpha 4 l homeolog (xenopus laevis)) (aka actinin alpha 4 l homeolog)
B: actin;actin-4 (caenorhabditis elegans) (aka actin;actin-4)
C: actinin-4 (homo sapiens) (aka actinin alpha 4)
D: actn4.l (xenopus laevis) (actinin alpha 4 s homeolog (xenopus l... | [C] |
<Instruct>: Given the context 'These findings suggest that cytoplasmic actinin-4 regulates the actin cytoskeleton and increases cellular motility and that its inactivation by transfer to the nucleus abolishes the metastatic potential of human cancers.', select the correct biomedical concept for each mention using the p... | <Mentions>: [actinin-4]
<Options>: A: actn4 (mus musculus) (aka actinin alpha 4)
B: actn4.l (xenopus laevis) (actinin alpha 4 l homeolog (xenopus laevis)) (aka actinin alpha 4 l homeolog)
C: actn4.l (xenopus laevis) (actinin alpha 4 s homeolog (xenopus laevis)) (aka actinin alpha 4 s homeolog)
D: actin;actin-4 (caenorh... | [E] |
<Instruct>: Given the context 'Considering the well established role of nonclassical HLA-G class I molecules in inhibiting natural killer (NK) cell function, the consequence of abnormal HLA-G expression in malignant cells should be the escape of tumors from immunosurveillance.', select the correct biomedical concept fo... | <Mentions>: [hla-g class i]
<Options>: A: major histocompatibility complex, class i, f (homo sapiens) (aka major histocompatibility complex, class i, f)
B: mhc class i polypeptide-related sequence g (pseudogene) (homo sapiens) (aka mhc class i polypeptide-related sequence g (pseudogene))
C: mhc-g (homo sapiens) (aka ma... | [C] |
<Instruct>: Given the context 'Our analysis of three melanoma cell lines and ex vivo biopsy demonstrated that (i) IGR and M74 human melanoma cell lines exhibit a high level of HLA-G transcription with differential HLA-G isoform transcription and protein expression patterns, (ii) a higher level of HLA-G transcription ex... | <Mentions>: [hla-g1]
<Options>: A: hla-z1 (homo sapiens) (aka major histocompatibility complex, class i, z (pseudogene))
B: major histocompatibility complex, class i, e (homo sapiens) (aka major histocompatibility complex, class i, e)
C: major histocompatibility complex, class i, g (homo sapiens) (aka major histocompat... | [C] |
<Instruct>: Given the context 'We have now cloned and characterized a third member of the synapsin gene family, synapsin III, from human DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [synapsin iii]
<Options>: A: synapsin-1 (homo sapiens) (aka synapsin-1)
B: synapsin ii (xenopus tropicalis) (aka synapsin ii)
C: synapsin iii (homo sapiens) (aka synapsin iii)
D: synapsin ii (homo sapiens) (aka synapsin ii)
E: synapsin iii (sus scrofa) (aka synapsin iii)
F: None of the above. | [C] |
<Instruct>: Given the context 'Synapsin III gives rise to at least one protein isoform, designated synapsin IIIa, in several mammalian species.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [synapsin iii; synapsin iiia]
<Options>: A: synapsin ii (xenopus tropicalis) (aka synapsin ii)
B: synapsin i (xenopus tropicalis) (aka synapsin i)
C: synapsin iii (homo sapiens) (aka synapsin iii)
D: synapsin (xenopus laevis) (synapsin i s homeolog (xenopus laevis)) (aka synapsin i s homeolog)
E: sytiii (ho... | [C; C] |
<Instruct>: Given the context 'Synapsin III gives rise to at least one protein isoform, designated synapsin IIIa, in several mammalian species.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [synapsin iii; synapsin iiia]
<Options>: A: synapsin-1 (homo sapiens) (aka synapsin-1)
B: synapsin iii (sus scrofa) (aka synapsin iii)
C: synapsin iii (homo sapiens) (aka synapsin iii)
D: synapsin iii (mus musculus) (aka synapsin iii)
E: synapsin ii (homo sapiens) (aka synapsin ii)
F: syniia (xenopus laevis... | [C; C] |
<Instruct>: Given the context 'Synapsin IIIa is associated with synaptic vesicles, and its expression appears to be neuron-specific.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [synapsin iiia]
<Options>: A: synapsin iii (sus scrofa) (aka synapsin iii)
B: synapsin iii (homo sapiens) (aka synapsin iii)
C: synapsin i (homo sapiens) (aka synapsin i)
D: synapsin ii (xenopus tropicalis) (aka synapsin ii)
E: synapsin iii (xenopus tropicalis) (aka synapsin iii)
F: None of the above. | [B] |
<Instruct>: Given the context 'The primary structure of synapsin IIIa conforms to the domain model previously described for the synapsin family, with domains A, C, and E exhibiting the highest degree of conservation.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [synapsin iiia]
<Options>: A: synapsin iii (homo sapiens) (aka synapsin iii)
B: synapsin iii (sus scrofa) (aka synapsin iii)
C: synapsin (xenopus laevis) (synapsin i s homeolog (xenopus laevis)) (aka synapsin i s homeolog)
D: synapsin i (homo sapiens) (aka synapsin i)
E: synapsin ii (xenopus tropicalis) (ak... | [A] |
<Instruct>: Given the context 'Synapsin IIIa contains a novel domain, termed domain J, located between domains C and E. The similarities among synapsins I, II, and III in domain organization, neuron-specific expression, and subcellular localization suggest a possible role for synapsin III in the regulation of neurotran... | <Mentions>: [synapsin iiia; synapsin iii]
<Options>: A: synapsin-1 (homo sapiens) (aka synapsin-1)
B: synapsin (xenopus laevis) (synapsin i s homeolog (xenopus laevis)) (aka synapsin i s homeolog)
C: synapsin i (xenopus tropicalis) (aka synapsin i)
D: synapsin iii (xenopus tropicalis) (aka synapsin iii)
E: synapsin iii... | [E; E] |
<Instruct>: Given the context 'Synapsin IIIa contains a novel domain, termed domain J, located between domains C and E. The similarities among synapsins I, II, and III in domain organization, neuron-specific expression, and subcellular localization suggest a possible role for synapsin III in the regulation of neurotran... | <Mentions>: [synapsin iiia; synapsin iii]
<Options>: A: synapsin (xenopus laevis) (synapsin i s homeolog (xenopus laevis)) (aka synapsin i s homeolog)
B: synapsin iii (xenopus tropicalis) (aka synapsin iii)
C: synapsin iii (homo sapiens) (aka synapsin iii)
D: synapsin iii (mus musculus) (aka synapsin iii)
E: syn1 (xeno... | [C; C] |
<Instruct>: Given the context 'The human synapsin III gene is located on chromosome 22q12-13, which has been identified as a possible schizophrenia susceptibility locus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [synapsin iii]
<Options>: A: sytiii (homo sapiens) (aka synaptotagmin 3)
B: synapsin i (homo sapiens) (aka synapsin i)
C: synapsin iii (xenopus tropicalis) (aka synapsin iii)
D: synapsin iii (mus musculus) (aka synapsin iii)
E: synapsin iii (homo sapiens) (aka synapsin iii)
F: None of the above. | [E] |
<Instruct>: Given the context 'On the basis of this localization and the well established neurobiological roles of the synapsins, synapsin III represents a candidate gene for schizophrenia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [synapsin iii]
<Options>: A: synapsin ii (xenopus tropicalis) (aka synapsin ii)
B: synapsin iii (mus musculus) (aka synapsin iii)
C: synapsin iii (homo sapiens) (aka synapsin iii)
D: synapsin-1 (homo sapiens) (aka synapsin-1)
E: synapsin ii (homo sapiens) (aka synapsin ii)
F: None of the above. | [C] |
<Instruct>: Given the context 'In this study we investigated the effects of eight muscarinic ligands on the rate constants for endocytosis and recycling of m3 muscarinic acetylcholine receptors in human SH-SY5Y neuroblastoma cells.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [m3 muscarinic acetylcholine receptors]
<Options>: A: cholinergic receptor, muscarinic 3 (xenopus tropicalis) (aka cholinergic receptor, muscarinic 3)
B: cholinergic receptor, muscarinic 3, cardiac (mus musculus) (aka cholinergic receptor, muscarinic 3, cardiac)
C: cholinergic receptor muscarinic 3 (homo sa... | [C] |
<Instruct>: Given the context 'Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks.
DNA ligase IV in a complex with XRCC4 is responsible for DNA end-joining in repair of DNA double-strand breaks (DSB) and V(D)J recombination.', select the correct biomedical concept for each... | <Mentions>: [dna ligase iv; xrcc4]
<Options>: A: xrcc7 (homo sapiens) (aka protein kinase, dna-activated, catalytic subunit)
B: lig4 (saccharomyces cerevisiae s288c) (aka dna ligase (atp) dnl4)
C: xrcc9 (homo sapiens) (aka fa complementation group g)
D: homolog of human dna ligase iv-binding protein xrcc4 (arabidopsis ... | [E; J] |
<Instruct>: Given the context 'Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks.
DNA ligase IV in a complex with XRCC4 is responsible for DNA end-joining in repair of DNA double-strand breaks (DSB) and V(D)J recombination.', select the correct biomedical concept for each... | <Mentions>: [dna ligase iv; xrcc4]
<Options>: A: xrcc4 (xenopus laevis) (aka x-ray repair complementing defective repair in chinese hamster cells 4 l homeolog)
B: dna ligase iv (caenorhabditis elegans) (aka dna ligase iv)
C: dna ligase 4-like (xenopus laevis) (aka dna ligase 4-like)
D: ligase iv, dna, atp-dependent (xe... | [H; G] |
<Instruct>: Given the context 'Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks.
DNA ligase IV in a complex with XRCC4 is responsible for DNA end-joining in repair of DNA double-strand breaks (DSB) and V(D)J recombination.', select the correct biomedical concept for each... | <Mentions>: [dna ligase iv; xrcc4]
<Options>: A: xrcc5 (homo sapiens) (aka x-ray repair cross complementing 5)
B: dna ligase 4 (homo sapiens) (aka dna ligase 4)
C: xrcc9 (homo sapiens) (aka fa complementation group g)
D: xrcc4 (xenopus laevis) (aka x-ray repair complementing defective repair in chinese hamster cells 4 ... | [B; J] |
<Instruct>: Given the context 'We found that non-histone chromosomal high mobility group (HMG) proteins 1 and 2 enhanced the ligation of linearized pUC119 DNA with DNA ligase IV from rat liver nuclear extract.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [dna ligase iv]
<Options>: A: dna ligase iv (caenorhabditis elegans) (aka dna ligase iv)
B: dna ligase 4 (oryctolagus cuniculus) (aka dna ligase 4)
C: dna ligase 4 (homo sapiens) (aka dna ligase 4)
D: ligase iv (drosophila melanogaster) (aka dna ligase 4)
E: dna ligase iv (arabidopsis thaliana) (aka dna lig... | [C] |
<Instruct>: Given the context 'Recombinant HMG2-domain A, B, and (A + B) polypeptides were similarly, but non-identically, effective for the stimulation of DSB ligation reaction.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [hmg2]
<Options>: A: high mobility group box 2 (homo sapiens) (aka high mobility group box 2)
B: hmg2l1 (homo sapiens) (aka hmg-box containing 4)
C: hmg-2a (homo sapiens) (aka high mobility group box 3)
D: high mobility group at-hook 2 (homo sapiens) (aka high mobility group at-hook 2)
E: hmgn2 (homo sapien... | [A] |
<Instruct>: Given the context 'The DNA end-binding Ku protein singly or in combination with the catalytic component of DNA-dependent protein kinase (DNA-PK) as the DNA-PK holoenzyme was ineffective for the ligation of linearized pUC119 DNA.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [dna-dependent protein kinase; dna-pk]
<Options>: A: dna-pkcs (xenopus tropicalis) (aka protein kinase, dna-activated, catalytic subunit)
B: protein kinase, dna activated, catalytic polypeptide (mus musculus) (aka protein kinase, dna activated, catalytic polypeptide)
C: chaperone protein dnak (escherichia c... | [G; G] |
<Instruct>: Given the context 'The DNA end-binding Ku protein singly or in combination with the catalytic component of DNA-dependent protein kinase (DNA-PK) as the DNA-PK holoenzyme was ineffective for the ligation of linearized pUC119 DNA.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [dna-dependent protein kinase; dna-pk]
<Options>: A: dna-pkcs (xenopus laevis) (aka protein kinase, dna-activated, catalytic subunit l homeolog)
B: chaperone protein dnak (escherichia coli str. k-12 substr. mg1655) (aka chaperone protein dnak)
C: dnapk (homo sapiens) (aka protein kinase, dna-activated, cata... | [C; C] |
<Instruct>: Given the context 'Although the stimulatory effect of HMG1 and 2 on ligation of DSB in vitro was not specific to DNA ligase IV, these results suggest that HMG1 and 2 are involved in the final ligation step in DNA end-joining processes of DSB repair and V(D)J recombination.', select the correct biomedical co... | <Mentions>: [dna ligase iv]
<Options>: A: dna ligase 4 (oryctolagus cuniculus) (aka dna ligase 4)
B: dna ligase iv (caenorhabditis elegans) (aka dna ligase iv)
C: ligase iv, dna, atp-dependent (xenopus tropicalis) (aka ligase iv, dna, atp-dependent)
D: dna ligase 4 (homo sapiens) (aka dna ligase 4)
E: lig4 (saccharomyc... | [D] |
<Instruct>: Given the context 'A search of the yeast data base for a protein homologous to Escherichia coli UDP-N-acetylglucosamine pyrophosphorylase yielded UAP1 (UDP-N-acetylglucosamine pyrophosphorylase), the Saccharomyces cerevisiae gene for UDP-N-acetylglucosamine pyrophosphorylase.', select the correct biomedical... | <Mentions>: [uap1]
<Options>: A: upf1 regulator of nonsense transcripts homolog (xenopus tropicalis) (aka upf1 regulator of nonsense transcripts homolog)
B: uap1l1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
C: uap1 (saccharomyces cerevisiae s288c) (aka udp-n-acetylglucosamine diphosphorylas... | [C] |
<Instruct>: Given the context 'Sequence analysis revealed that the human UAP1 cDNA was identical to previously reported AGX1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [uap1; agx1]
<Options>: A: agx1 (xenopus laevis) (udp-n-acetylglucosamine pyrophosphorylase 1 s homeolog (xenopus laevis)) (aka udp-n-acetylglucosamine pyrophosphorylase 1 s homeolog)
B: agmx1 (homo sapiens) (aka bruton tyrosine kinase)
C: uap (homo sapiens) (aka ubiquitin associated protein 1)
D: uap1 (sac... | [H; H] |
<Instruct>: Given the context 'Sequence analysis revealed that the human UAP1 cDNA was identical to previously reported AGX1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [uap1; agx1]
<Options>: A: upf1 regulator of nonsense transcripts homolog (xenopus tropicalis) (aka upf1 regulator of nonsense transcripts homolog)
B: uap1 (saccharomyces cerevisiae s288c) (aka udp-n-acetylglucosamine diphosphorylase)
C: agx1 (saccharomyces cerevisiae s288c) (aka alanine--glyoxylate transam... | [I; I] |
<Instruct>: Given the context 'Sequence analysis revealed that the human UAP1 cDNA was identical to previously reported AGX1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [uap1; agx1]
<Options>: A: agmx1 (homo sapiens) (aka bruton tyrosine kinase)
B: agx1 (xenopus tropicalis) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
C: ag1 (xenopus laevis) (anterior gradient 1 l homeolog (xenopus laevis)) (aka anterior gradient 1 l homeolog)
D: uap1 (saccharomyces cerevisiae s288c) ... | [G; G] |
<Instruct>: Given the context 'A null mutation of the S. cerevisiae UAP1 (ScUAP1) gene was lethal, and when expressed under the control of ScUAP1 promoter, both C. albicans and Homo sapiens UAP1 (CaUAP1 and HsUAP1) rescued the ScUAP1-deficient S. cerevisiae cells.', select the correct biomedical concept for each mentio... | <Mentions>: [uap1; scuap1; hsuap1]
<Options>: A: uap1 (saccharomyces cerevisiae s288c) (aka udp-n-acetylglucosamine diphosphorylase)
B: upf1 regulator of nonsense transcripts homolog (xenopus tropicalis) (aka upf1 regulator of nonsense transcripts homolog)
C: azu1p1 (homo sapiens) (aka azurocidin 1 pseudogene 1)
D: uap... | [A; A; F] |
<Instruct>: Given the context 'A null mutation of the S. cerevisiae UAP1 (ScUAP1) gene was lethal, and when expressed under the control of ScUAP1 promoter, both C. albicans and Homo sapiens UAP1 (CaUAP1 and HsUAP1) rescued the ScUAP1-deficient S. cerevisiae cells.', select the correct biomedical concept for each mentio... | <Mentions>: [uap1; scuap1; hsuap1]
<Options>: A: uap1 (saccharomyces cerevisiae s288c) (aka udp-n-acetylglucosamine diphosphorylase)
B: upla1 (homo sapiens) (aka gjd3 antisense rna 1)
C: uap1 (xenopus tropicalis) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
D: uap1l1 (sus scrofa) (aka udp-n-acetylglucosamine pyrop... | [A; A; O] |
<Instruct>: Given the context 'A null mutation of the S. cerevisiae UAP1 (ScUAP1) gene was lethal, and when expressed under the control of ScUAP1 promoter, both C. albicans and Homo sapiens UAP1 (CaUAP1 and HsUAP1) rescued the ScUAP1-deficient S. cerevisiae cells.', select the correct biomedical concept for each mentio... | <Mentions>: [uap1; scuap1; hsuap1]
<Options>: A: cluap1 (homo sapiens) (aka clusterin associated protein 1)
B: upp1 (homo sapiens) (aka uridine phosphorylase 1)
C: uap1l1 (sus scrofa) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
D: uap1l1 (xenopus tropicalis) (aka udp-n-acetylglucosamine pyrophosphorylase 1... | [I; I; J] |
<Instruct>: Given the context 'A null mutation of the S. cerevisiae UAP1 (ScUAP1) gene was lethal, and when expressed under the control of ScUAP1 promoter, both C. albicans and Homo sapiens UAP1 (CaUAP1 and HsUAP1) rescued the ScUAP1-deficient S. cerevisiae cells.', select the correct biomedical concept for each mentio... | <Mentions>: [scuap1]
<Options>: A: cluap1 (homo sapiens) (aka clusterin associated protein 1)
B: uap1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
C: uca1 (homo sapiens) (aka urothelial cancer associated 1)
D: clusterin associated protein 1 (sus scrofa) (aka clusterin associated protein 1)
E: cluap1... | [F] |
<Instruct>: Given the context 'All the recombinant ScUap1p, CaUap1p, and HsUap1p possessed UDP-N-acetylglucosamine pyrophosphorylase activities in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [scuap1p; hsuap1p]
<Options>: A: uap1 (sus scrofa) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
B: usp37p1 (homo sapiens) (aka usp37 pseudogene 1)
C: uap1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
D: serum serum amyloid a-1 pseudogene (sus scrofa) (aka serum serum amyloid a-1 pse... | [K; C] |
<Instruct>: Given the context 'All the recombinant ScUap1p, CaUap1p, and HsUap1p possessed UDP-N-acetylglucosamine pyrophosphorylase activities in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [scuap1p; hsuap1p]
<Options>: A: uap1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
B: upp1 (sus scrofa) (aka uridine phosphorylase 1)
C: high affinity copper uptake protein 1 pseudogene (sus scrofa) (aka high affinity copper uptake protein 1 pseudogene)
D: uap1 (sus scrofa) (aka udp-n-ac... | [I; A] |
<Instruct>: Given the context 'The yeast Uap1p utilized N-acetylglucosamine-1-phosphate as the substrate, and together with Agm1p, it produced UDP-N-acetylglucosamine from N-acetylglucosamine-6-phosphate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [uap1p; agm1p]
<Options>: A: uap1l1 (xenopus tropicalis) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
B: uap1 (saccharomyces cerevisiae s288c) (aka udp-n-acetylglucosamine diphosphorylase)
C: 1-agp (mus musculus) (aka 1-acylglycerol-3-phosphate o-acyltransferase 1)
D: agp-1 (mus musculus) (oroso... | [B; F] |
<Instruct>: Given the context 'The yeast Uap1p utilized N-acetylglucosamine-1-phosphate as the substrate, and together with Agm1p, it produced UDP-N-acetylglucosamine from N-acetylglucosamine-6-phosphate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [uap1p; agm1p]
<Options>: A: agp-1 (mus musculus) (orosomucoid 1 (mus musculus)) (aka orosomucoid 1)
B: uap (homo sapiens) (aka ubiquitin associated protein 1)
C: 1-agp (mus musculus) (aka 1-acylglycerol-3-phosphate o-acyltransferase 1)
D: uap1 (saccharomyces cerevisiae s288c) (aka udp-n-acetylglucosamine d... | [D; F] |
<Instruct>: Given the context 'The yeast Uap1p utilized N-acetylglucosamine-1-phosphate as the substrate, and together with Agm1p, it produced UDP-N-acetylglucosamine from N-acetylglucosamine-6-phosphate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [uap1p; agm1p]
<Options>: A: uap1 (xenopus laevis) (udp-n-acetylglucosamine pyrophosphorylase 1 l homeolog (xenopus laevis)) (aka udp-n-acetylglucosamine pyrophosphorylase 1 l homeolog)
B: agm1 (saccharomyces cerevisiae s288c) (aka phosphoacetylglucosamine mutase pcm1)
C: uap1l1 (xenopus laevis) (aka udp-n-... | [J; B] |
<Instruct>: Given the context 'These results demonstrate that the UAP1 genes indeed specify eukaryotic UDP-GlcNAc pyrophosphorylase and that phosphomutase reaction precedes uridyltransfer.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [uap1]
<Options>: A: uap1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
B: upp1 (homo sapiens) (aka uridine phosphorylase 1)
C: upf1 regulator of nonsense transcripts homolog (xenopus tropicalis) (aka upf1 regulator of nonsense transcripts homolog)
D: uap1 (saccharomyces cerevisiae s288c)... | [A] |
<Instruct>: Given the context 'Sequence comparison with other UDP-sugar pyrophosphorylases revealed that amino acid residues, Gly112, Gly114, Thr115, Arg116, Pro122, and Lys123 of ScUap1p are highly conserved in UDP-sugar pyrophosphorylases reported to date.', select the correct biomedical concept for each mention usin... | <Mentions>: [scuap1p]
<Options>: A: serum serum amyloid a-1 pseudogene (sus scrofa) (aka serum serum amyloid a-1 pseudogene)
B: cluap1 (xenopus laevis) (aka clusterin associated protein 1 l homeolog)
C: high affinity copper uptake protein 1 pseudogene (sus scrofa) (aka high affinity copper uptake protein 1 pseudogene)
... | [F] |
<Instruct>: Given the context 'Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.
Mxi1 belongs to the Mad (Mxi1) family of proteins, which function as potent antagonists of Myc oncoproteins.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [mxi1; myc]
<Options>: A: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
B: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
C: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis vira... | [J; I] |
<Instruct>: Given the context 'Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.
Mxi1 belongs to the Mad (Mxi1) family of proteins, which function as potent antagonists of Myc oncoproteins.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [mxi1; myc]
<Options>: A: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
B: mx1 (mus musculus) (aka mx dynamin-like gtpase 1)
C: myc (mus musculus) (myelocytomatosis oncogene (mus musc... | [F; J] |
<Instruct>: Given the context 'This antagonism relates partly to their ability to compete with Myc for the protein Max and for consensus DNA binding sites and to recruit transcriptional co-repressors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [myc; max]
<Options>: A: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
B: basic helix-loop-helix transcription factor (glycine max) (aka basic helix-loop-helix transcription factor)
C: myc (mus musculus) (myelocytomatosis oncoge... | [E; G] |
<Instruct>: Given the context 'This antagonism relates partly to their ability to compete with Myc for the protein Max and for consensus DNA binding sites and to recruit transcriptional co-repressors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [myc; max]
<Options>: A: basic helix-loop-helix transcription factor (glycine max) (aka basic helix-loop-helix transcription factor)
B: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
C: max (homo sapiens) (aka myc associated factor x)
D: myc proto-oncogene, bhlh transcription facto... | [D; C] |
<Instruct>: Given the context 'This antagonism relates partly to their ability to compete with Myc for the protein Max and for consensus DNA binding sites and to recruit transcriptional co-repressors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [myc; max]
<Options>: A: max (mus musculus) (aka max protein)
B: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
C: basic helix-loop-helix (bhlh) dna-binding protein (glycine max) (aka basic helix-loop-helix (bhlh) dna-binding protein)
D: basic helix-loop-helix transcription factor ... | [H; I] |
<Instruct>: Given the context 'Mad(Mxi1) proteins have been suggested to be essential in cellular growth control and/or in the induction and maintenance of the differentiated state.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [mxi1]
<Options>: A: mxi (xenopus laevis) (max interactor 1, dimerization protein s homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein s homeolog)
B: mxi (xenopus laevis) (max interactor 1, dimerization protein l homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein l ho... | [C] |
<Instruct>: Given the context 'Consistent with these roles, mxi1 may be the tumour-suppressor gene that resides at region 24-26 of the long arm of chromosome 10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [mxi1]
<Options>: A: mxi (xenopus laevis) (max interactor 1, dimerization protein l homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein l homeolog)
B: mxi (homo sapiens) (aka max interactor 1, dimerization protein)
C: mxi (xenopus laevis) (max interactor 1, dimerization protein s homeolog... | [B] |
<Instruct>: Given the context 'Here we show that mice lacking Mxi1 exhibit progressive, multisystem abnormalities.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mxi1]
<Options>: A: max interactor 1, dimerization protein (mus musculus) (aka max interactor 1, dimerization protein)
B: mx1 (homo sapiens) (aka mx dynamin like gtpase 1)
C: mxi (xenopus laevis) (max interactor 1, dimerization protein l homeolog (xenopus laevis)) (aka max interactor 1, dimerization protei... | [A] |
<Instruct>: Given the context 'These mice also show increased susceptibility to tumorigenesis either following carcinogen treatment or when also deficient in Ink4a.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [ink4a]
<Options>: A: p16ink4 (homo sapiens) (aka cyclin dependent kinase inhibitor 2a)
B: ink4b (homo sapiens) (aka cyclin dependent kinase inhibitor 2b)
C: ink4c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
D: cdkn4 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
E: ink4d (homo sapi... | [F] |
<Instruct>: Given the context 'This cancer-prone phenotype may correlate with the enhanced ability of several mxi1-deficient cell types, including prostatic epithelium, to proliferate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [mxi1]
<Options>: A: mxi1 (mus musculus) (aka max interactor 1, dimerization protein)
B: mx1 (homo sapiens) (aka mx dynamin like gtpase 1)
C: mxi1 (homo sapiens) (aka max interactor 1, dimerization protein)
D: mx-1 (mus musculus) (aka mx dynamin-like gtpase 1)
E: mxi (xenopus laevis) (max interactor 1, dime... | [A] |
<Instruct>: Given the context 'Our results show that Mxi1 is involved in the homeostasis of differentiated organ systems, acts as a tumour suppressor in vivo, and engages the Myc network in a functionally relevant manner.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [mxi1; myc]
<Options>: A: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
B: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
C: mxi (xenopus laevis) (max int... | [D; I] |
<Instruct>: Given the context 'Our results show that Mxi1 is involved in the homeostasis of differentiated organ systems, acts as a tumour suppressor in vivo, and engages the Myc network in a functionally relevant manner.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [mxi1; myc]
<Options>: A: max interactor 1, dimerization protein (mus musculus) (aka max interactor 1, dimerization protein)
B: mxi (xenopus laevis) (max interactor 1, dimerization protein s homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein s homeolog)
C: myc (mus musculus) (myelocytoma... | [F; J] |
<Instruct>: Given the context 'DNA sequence and muscle-specific expression of human sarcosin transcripts.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sarcosin]
<Options>: A: sarcosinemia autosomal recessive (mus musculus) (aka sarcosinemia autosomal recessive)
B: sarcosin (homo sapiens) (aka kelch like family member 41)
C: sarcc (homo sapiens) (aka purinergic receptor p2y1)
D: sarcosin (mus musculus) (aka kelch-like 41)
E: sarcosin (xenopus tropicalis) ... | [B] |
<Instruct>: Given the context 'DNA sequence and muscle-specific expression of human sarcosin transcripts.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sarcosin]
<Options>: A: sarcosinemia autosomal recessive (mus musculus) (aka sarcosinemia autosomal recessive)
B: sarcc (homo sapiens) (aka purinergic receptor p2y1)
C: sarcosin (mus musculus) (aka kelch-like 41)
D: sarcosin (xenopus tropicalis) (aka kelch like family member 41)
E: None of the above. | [E] |
<Instruct>: Given the context 'Consequently, we have termed this novel human sequence sarcosin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sarcosin]
<Options>: A: sarcosin (homo sapiens) (aka kelch like family member 41)
B: sarcosin (mus musculus) (aka kelch-like 41)
C: sarcosin (danio rerio) (aka kelch-like family member 41b)
D: sarcc (homo sapiens) (aka purinergic receptor p2y1)
E: sarcosinemia autosomal recessive (mus musculus) (aka sarcos... | [A] |
<Instruct>: Given the context 'Although novel, Southern hybridization analysis demonstrated that the sarcosin sequence has been conserved in several mammalian species.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [sarcosin]
<Options>: A: sarcosin (xenopus tropicalis) (aka kelch like family member 41)
B: sarcosin (rattus norvegicus) (aka kelch-like family member 41)
C: sarcospan (mus musculus) (aka sarcospan)
D: sarcosinemia autosomal recessive (mus musculus) (aka sarcosinemia autosomal recessive)
E: sarcosin (homo s... | [E] |
<Instruct>: Given the context 'Best macular dystrophy (BMD), also known as vitelliform macular dystrophy (VMD2; OMIM 153700), is an autosomal dominant form of macular degeneration characterized by an abnormal accumulation of lipofuscin within and beneath the retinal pigment epithelium cells.', select the correct biomed... | <Mentions>: [vmd2]
<Options>: A: vmd4 (homo sapiens) (aka interphotoreceptor matrix proteoglycan 1)
B: vmd2l1 (homo sapiens) (aka bestrophin 2)
C: vm2 (drosophila melanogaster) (aka visible mutation-2)
D: vmd2 (homo sapiens) (aka bestrophin 1)
E: vmd2l2 (homo sapiens) (aka bestrophin 4)
F: None of the above. | [D] |
<Instruct>: Given the context 'In pursuit of the disease gene, we limited the minimum genetic region by recombination breakpoint analysis and mapped to this region a novel retina-specific gene (VMD2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [vmd2]
<Options>: A: mvcd2 (homo sapiens) (aka erythropoietin)
B: vmd2 (homo sapiens) (aka bestrophin 1)
C: vmd4 (homo sapiens) (aka interphotoreceptor matrix proteoglycan 1)
D: vmd1 (homo sapiens) (aka vitelliform macular dystrophy, atypical)
E: vmd2l3 (homo sapiens) (aka bestrophin 3)
F: None of the above... | [B] |
<Instruct>: Given the context 'The 3' UTR of the candidate gene contains a region of antisense complementarity to the 3' UTR of the ferritin heavy-chain gene (FTH1), indicating the possibility of antisense interaction between VMD2 and FTH1 transcripts.', select the correct biomedical concept for each mention using the ... | <Mentions>: [fth1; vmd2]
<Options>: A: vmd1 (homo sapiens) (aka vitelliform macular dystrophy, atypical)
B: vmd2l3 (homo sapiens) (aka bestrophin 3)
C: ft1 (homo sapiens) (aka akt interacting protein)
D: vmd2l2 (homo sapiens) (aka bestrophin 4)
E: vmd2 (homo sapiens) (aka bestrophin 1)
F: fth1 (homo sapiens) (aka ferri... | [F; E] |
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