instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
|---|---|---|
<Instruct>: Given the context 'In adult brain, FMR1, FXR1 and FXR2 proteins are coexpressed in the cytoplasm of specific differentiated neurons only.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: fmr1 autosomal homolog 1 (xenopus tropicalis) (xtfxr1p-a (xenopus tropicalis)) (aka fmr1 autosomal homolog 1)
B: fxr (drosophila melanogaster) (fizzy-related (drosophila melanogaster)) (aka fizzy-related)
C: fmr1 autosomal homolog 1 (mus musculus) (aka fmr1 autosomal homolog... | [O; F; D] |
<Instruct>: Given the context 'In adult brain, FMR1, FXR1 and FXR2 proteins are coexpressed in the cytoplasm of specific differentiated neurons only.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: fxr (xenopus tropicalis) (aka nuclear receptor subfamily 1 group h member 4)
B: fmr1 autosomal homolog 1 (xenopus tropicalis) (frx1l (xenopus tropicalis)) (aka fmr1 autosomal homolog 1)
C: fxrb (homo sapiens) (aka nuclear receptor subfamily 1 group h member 5, pseudogene)
D:... | [N; F; I] |
<Instruct>: Given the context 'PHOG, a candidate gene for involvement in the short stature of Turner syndrome.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [phog]
<Options>: A: phop (escherichia coli str. k-12 substr. mg1655) (aka dna-binding transcriptional dual regulator phop)
B: phos (escherichia coli str. k-12 substr. mg1655) (aka phosphate abc transporter periplasmic binding protein)
C: pho85 (saccharomyces cerevisiae s288c) (aka cyclin-dependent serine/t... | [D] |
<Instruct>: Given the context 'We have named the gene PHOG, for pseudoautosomal homeobox-containing osteogenic gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [phog; pseudoautosomal homeobox-containing osteogenic gene]
<Options>: A: phog1 (homo sapiens) (aka shox homeobox)
B: sebox homeobox (homo sapiens) (aka sebox homeobox)
C: phosphoglycolate phosphatase (homo sapiens) (aka phosphoglycolate phosphatase)
D: phos (escherichia coli str. k-12 substr. mg1655) (aka ... | [A; A] |
<Instruct>: Given the context 'We have named the gene PHOG, for pseudoautosomal homeobox-containing osteogenic gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [phog; pseudoautosomal homeobox-containing osteogenic gene]
<Options>: A: phosphoglycolate phosphatase (homo sapiens) (aka phosphoglycolate phosphatase)
B: osteoglycin s homeolog (xenopus laevis) (aka osteoglycin s homeolog)
C: sulfite oxidase pseudogene (homo sapiens) (aka sulfite oxidase pseudogene)
D: oo... | [G; G] |
<Instruct>: Given the context 'Its deletion in patients with short stature, the predicted altered dosage in 45,X individuals, along with the nature of the encoded protein and its expression pattern, make PHOG an attractive candidate for involvement in the short stature of Turner syndrome.', select the correct biomedica... | <Mentions>: [phog]
<Options>: A: phos (escherichia coli str. k-12 substr. mg1655) (aka phosphate abc transporter periplasmic binding protein)
B: pp2cg (homo sapiens) (aka protein phosphatase, mg2+/mn2+ dependent 1g)
C: hptpg (homo sapiens) (aka protein tyrosine phosphatase receptor type g)
D: phoh (escherichia coli str... | [E] |
<Instruct>: Given the context 'Its deletion in patients with short stature, the predicted altered dosage in 45,X individuals, along with the nature of the encoded protein and its expression pattern, make PHOG an attractive candidate for involvement in the short stature of Turner syndrome.', select the correct biomedica... | <Mentions>: [phog]
<Options>: A: pp2cg (homo sapiens) (aka protein phosphatase, mg2+/mn2+ dependent 1g)
B: phoh (escherichia coli str. k-12 substr. mg1655) (aka atp-binding protein phoh)
C: hptpg (homo sapiens) (aka protein tyrosine phosphatase receptor type g)
D: phos (escherichia coli str. k-12 substr. mg1655) (aka p... | [E] |
<Instruct>: Given the context 'We have also found that the mouse homolog of PHOG is autosomal, which may help to explain the lack of a growth abnormality in mice with monosomy X.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [phog]
<Options>: A: phosphoglycolate phosphatase (homo sapiens) (aka phosphoglycolate phosphatase)
B: phoh (escherichia coli str. k-12 substr. mg1655) (aka atp-binding protein phoh)
C: pho85 (saccharomyces cerevisiae s288c) (aka cyclin-dependent serine/threonine-protein kinase pho85)
D: phog1 (homo sapiens... | [D] |
<Instruct>: Given the context 'cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [stat4; stat1]
<Options>: A: signal transducer and activator of transcription 5a (homo sapiens) (aka signal transducer and activator of transcription 5a)
B: il-4-statb (homo sapiens) (aka signal transducer and activator of transcription 6)
C: signal transducer and activator of transcription 2 (homo sapiens)... | [G; D] |
<Instruct>: Given the context 'cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [stat4; stat1]
<Options>: A: signal transducer and activator of transcription 1 (xenopus tropicalis) (aka signal transducer and activator of transcription 1)
B: signal transducer and activator of transcription 2 (homo sapiens) (aka signal transducer and activator of transcription 2)
C: signal transducer and... | [C; G] |
<Instruct>: Given the context 'STAT4 is phosphorylated following interleukin (IL)-12 stimulation and is essential for IL-12 signal transduction.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stat4]
<Options>: A: il-4-statb (homo sapiens) (aka signal transducer and activator of transcription 6)
B: cis4 (homo sapiens) (aka suppressor of cytokine signaling 6)
C: stat4 (bos taurus) (aka signal transducer and activator of transcription 4)
D: signal transducer and activator of transcription 4 (xenop... | [E] |
<Instruct>: Given the context 'The human STAT4 cDNA was cloned, and both STAT4 and STAT1 genes were mapped to human chromosome bands 2q32.2-->q32.3 by fluorescence in situ hybridization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [stat4; stat1]
<Options>: A: signal transducer and activator of transcription 1 (xenopus tropicalis) (aka signal transducer and activator of transcription 1)
B: stat4 (xenopus tropicalis) (aka signal transducer and activator of transcription 4)
C: il-4-statb (homo sapiens) (aka signal transducer and activat... | [E; F] |
<Instruct>: Given the context 'The human STAT4 cDNA was cloned, and both STAT4 and STAT1 genes were mapped to human chromosome bands 2q32.2-->q32.3 by fluorescence in situ hybridization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [stat4; stat1]
<Options>: A: signal transducer and activator of transcription 4 (homo sapiens) (aka signal transducer and activator of transcription 4)
B: stat2 (homo sapiens) (aka signal transducer and activator of transcription 2)
C: stat3 (homo sapiens) (aka signal transducer and activator of transcripti... | [J; I] |
<Instruct>: Given the context 'The human STAT4 cDNA was cloned, and both STAT4 and STAT1 genes were mapped to human chromosome bands 2q32.2-->q32.3 by fluorescence in situ hybridization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [stat4; stat1]
<Options>: A: stat2 (homo sapiens) (aka signal transducer and activator of transcription 2)
B: signal transducer and activator of transcription 1 (xenopus tropicalis) (aka signal transducer and activator of transcription 1)
C: stat3 (homo sapiens) (aka signal transducer and activator of trans... | [J; D] |
<Instruct>: Given the context 'These results suggest that STAT4 and STAT1 may have arisen via a tandem gene duplication.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stat4; stat1]
<Options>: A: cis4 (homo sapiens) (aka suppressor of cytokine signaling 6)
B: signal transducer and activator of transcription 1 (xenopus tropicalis) (aka signal transducer and activator of transcription 1)
C: signal transducer and activator of transcription 4 (homo sapiens) (aka signal trans... | [C; E] |
<Instruct>: Given the context 'These results suggest that STAT4 and STAT1 may have arisen via a tandem gene duplication.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stat4; stat1]
<Options>: A: stat4 (homo sapiens) (aka signal transducer and activator of transcription 4)
B: il-4-statb (homo sapiens) (aka signal transducer and activator of transcription 6)
C: signal transducer and activator of transcription 2 (homo sapiens) (aka signal transducer and activator of transc... | [A; H] |
<Instruct>: Given the context 'However, human STAT1 is expressed ubiquitously, whereas human STAT4 is expressed in several tissues including spleen, heart, brain, peripheral blood cells, and testis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [stat1; stat4]
<Options>: A: signal transducer and activator of transcription 4 (homo sapiens) (aka signal transducer and activator of transcription 4)
B: cis-4 (homo sapiens) (aka suppressor of cytokine signaling 6)
C: il-4-statb (homo sapiens) (aka signal transducer and activator of transcription 6)
D: st... | [F; E] |
<Instruct>: Given the context 'However, human STAT1 is expressed ubiquitously, whereas human STAT4 is expressed in several tissues including spleen, heart, brain, peripheral blood cells, and testis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [stat1; stat4]
<Options>: A: signal transducer and activator of transcription 5a (homo sapiens) (aka signal transducer and activator of transcription 5a)
B: cis4 (homo sapiens) (aka suppressor of cytokine signaling 6)
C: il-4-statb (homo sapiens) (aka signal transducer and activator of transcription 6)
D: s... | [F; I] |
<Instruct>: Given the context 'Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [rab7l1]
<Options>: A: rab7l (xenopus laevis) (aka rab29, member ras oncogene family s homeolog)
B: rab7b, member ras oncogene family l homeolog (xenopus laevis) (aka rab7b, member ras oncogene family l homeolog)
C: rab7 (xenopus laevis) (rab7a, member ras oncogene family l homeolog (xenopus laevis)) (aka r... | [D] |
<Instruct>: Given the context 'A full-length cDNA homologous to RAB7, a member of the RAB-related GTP-binding protein subfamily, was isolated from a human placenta cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [rab7]
<Options>: A: rab7a (homo sapiens) (aka rab7a, member ras oncogene family)
B: rab7b (homo sapiens) (aka rab7b, member ras oncogene family)
C: rab7l (homo sapiens) (aka rab29, member ras oncogene family)
D: rab7 (xenopus laevis) (rab7a, member ras oncogene family l homeolog (xenopus laevis)) (aka rab7... | [A] |
<Instruct>: Given the context 'A full-length cDNA homologous to RAB7, a member of the RAB-related GTP-binding protein subfamily, was isolated from a human placenta cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [rab7]
<Options>: A: rab7l (homo sapiens) (aka rab29, member ras oncogene family)
B: rab7b (homo sapiens) (aka rab7b, member ras oncogene family)
C: rab7 (xenopus laevis) (rab7a, member ras oncogene family l homeolog (xenopus laevis)) (aka rab7a, member ras oncogene family l homeolog)
D: rab7 (drosophila me... | [E] |
<Instruct>: Given the context 'This cDNA, designated RAB7L1, has an open reading frame of 609 nucleotides encoding 203 amino acids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rab7l1]
<Options>: A: rab7l (xenopus tropicalis) (aka rab29, member ras oncogene family)
B: rab7b, member ras oncogene family l homeolog (xenopus laevis) (aka rab7b, member ras oncogene family l homeolog)
C: rab7l (drosophila melanogaster) (aka rab32)
D: rab7l1 (homo sapiens) (aka rab29, member ras oncogen... | [D] |
<Instruct>: Given the context 'In this work we provide a novel approach to this problem using a beta-arrestin2/green fluorescent protein conjugate (betaarr2-GFP).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [beta-arrestin2; betaarr2]
<Options>: A: arrestin, beta 2, pseudogene (rattus norvegicus) (aka arrestin, beta 2, pseudogene)
B: betaarr2 (xenopus tropicalis) (aka arrestin beta 2)
C: arrestin domain containing 2 (homo sapiens) (aka arrestin domain containing 2)
D: grin2b (homo sapiens) (aka glutamate ionotr... | [H; H] |
<Instruct>: Given the context 'In this work we provide a novel approach to this problem using a beta-arrestin2/green fluorescent protein conjugate (betaarr2-GFP).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [beta-arrestin2; betaarr2]
<Options>: A: arb2 (homo sapiens) (adrenoceptor beta 2 (homo sapiens)) (aka adrenoceptor beta 2)
B: adrb2r (homo sapiens) (aka adrenoceptor beta 2)
C: arr (drosophila melanogaster) (arrestin 2 (drosophila melanogaster)) (aka arrestin 2)
D: betaarr2 (xenopus tropicalis) (aka arrest... | [H; H] |
<Instruct>: Given the context 'Confocal microscopy demonstrates the translocation of betaarr2-GFP to more than 15 different ligand-activated GPCRs.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [betaarr2]
<Options>: A: betaarr2 (xenopus tropicalis) (aka arrestin beta 2)
B: grin2b (homo sapiens) (aka glutamate ionotropic receptor nmda type subunit 2b)
C: arrb2 (homo sapiens) (aka arrestin beta 2)
D: arb2 (homo sapiens) (adrenoceptor beta 2 (homo sapiens)) (aka adrenoceptor beta 2)
E: arrb2 (rattus ... | [C] |
<Instruct>: Given the context 'The use of betaarr2-GFP as a biosensor to recognize the activation of pharmacologically distinct GPCRs should accelerate the identification of orphan receptors and permit the optical study of their signal transduction biology intractable to ordinary biochemical methods.', select the corre... | <Mentions>: [betaarr2]
<Options>: A: arrestin, beta 2, pseudogene (rattus norvegicus) (aka arrestin, beta 2, pseudogene)
B: betaarr2 (xenopus tropicalis) (aka arrestin beta 2)
C: arb2 (homo sapiens) (adrenoceptor beta 2 (homo sapiens)) (aka adrenoceptor beta 2)
D: grin2b (homo sapiens) (aka glutamate ionotropic recepto... | [E] |
<Instruct>: Given the context 'Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor.
Hepatocyte growth factor (HGF) activator is a serine protease responsible for proteolytic activation of HGF in response to tissue injury and thus plays an important ro... | <Mentions>: [hepatocyte growth factor activator inhibitor type 2; hepatocyte growth factor (hgf) activator; hgf]
<Options>: A: serpin family i member 2 (homo sapiens) (aka serpin family i member 2)
B: pai-2 (homo sapiens) (aka serpin family b member 2)
C: hgf (homo sapiens) (hepatocyte growth factor (homo sapiens)) (ak... | [K; I; C] |
<Instruct>: Given the context 'Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor.
Hepatocyte growth factor (HGF) activator is a serine protease responsible for proteolytic activation of HGF in response to tissue injury and thus plays an important ro... | <Mentions>: [hepatocyte growth factor activator inhibitor type 2; hepatocyte growth factor (hgf) activator; hgf]
<Options>: A: hgfal (homo sapiens) (aka hyaluronan binding protein 2)
B: hgf (homo sapiens) (hepatocyte growth factor (homo sapiens)) (aka hepatocyte growth factor)
C: serine peptidase inhibitor kazal type 2... | [L; I; B] |
<Instruct>: Given the context 'Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor.
Hepatocyte growth factor (HGF) activator is a serine protease responsible for proteolytic activation of HGF in response to tissue injury and thus plays an important ro... | <Mentions>: [hepatocyte growth factor activator inhibitor type 2; hepatocyte growth factor (hgf) activator; hgf]
<Options>: A: hgf2 (homo sapiens) (aka gingival fibromatosis, hereditary, 2)
B: hgfal (homo sapiens) (aka hyaluronan binding protein 2)
C: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6... | [F; I; H] |
<Instruct>: Given the context 'Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor.
Hepatocyte growth factor (HGF) activator is a serine protease responsible for proteolytic activation of HGF in response to tissue injury and thus plays an important ro... | <Mentions>: [hepatocyte growth factor activator inhibitor type 2; hepatocyte growth factor (hgf) activator; hgf]
<Options>: A: hgf2 (homo sapiens) (aka gingival fibromatosis, hereditary, 2)
B: hgf5 (homo sapiens) (aka re1 silencing transcription factor)
C: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleu... | [K; H; M] |
<Instruct>: Given the context 'We previously purified an inhibitor of HGF activator (HGF activator inhibitor type 1, HAI-1) from the conditioned medium of a human stomach carcinoma cell line MKN45 and cloned its cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [hgf activator; hgf activator inhibitor type 1; hai-1]
<Options>: A: haip1 (homo sapiens) (aka baculoviral iap repeat containing 3)
B: hgfl (homo sapiens) (macrophage stimulating 1 (homo sapiens)) (aka macrophage stimulating 1)
C: antizyme inhibitor 1 (homo sapiens) (aka antizyme inhibitor 1)
D: hai (homo s... | [N; D; D] |
<Instruct>: Given the context 'We previously purified an inhibitor of HGF activator (HGF activator inhibitor type 1, HAI-1) from the conditioned medium of a human stomach carcinoma cell line MKN45 and cloned its cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [hgf activator; hgf activator inhibitor type 1; hai-1]
<Options>: A: hai-1 (xenopus tropicalis) (aka serine peptidase inhibitor, kunitz type 1)
B: hait1 (homo sapiens) (aka solute carrier family 71 member 1)
C: hai-1 (sus scrofa) (aka serine peptidase inhibitor, kunitz type 1)
D: hgf activator (rattus norve... | [K; M; M] |
<Instruct>: Given the context 'We previously purified an inhibitor of HGF activator (HGF activator inhibitor type 1, HAI-1) from the conditioned medium of a human stomach carcinoma cell line MKN45 and cloned its cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [hgf activator; hgf activator inhibitor type 1; hai-1]
<Options>: A: hepatocyte growth factor activator (mus musculus) (aka hepatocyte growth factor activator)
B: protein inhibitor of activated stat 1 (homo sapiens) (aka protein inhibitor of activated stat 1)
C: hai-2 (homo sapiens) (aka serine peptidase in... | [D; G; G] |
<Instruct>: Given the context 'HAI-1 is a novel member of the Kunitz family of serine protease inhibitors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hai-1]
<Options>: A: hai-1 (sus scrofa) (aka serine peptidase inhibitor, kunitz type 1)
B: hai1 (homo sapiens) (aka serine peptidase inhibitor, kunitz type 1)
C: hcinf1 (homo sapiens) (aka cytochrome p450 family 24 subfamily a member 1)
D: haik1 (homo sapiens) (aka keratin 23)
E: haip1 (homo sapiens) (aka ... | [B] |
<Instruct>: Given the context 'In the present study, we purified a second type of HGF activator inhibitor (HAI-2) from the conditioned medium of MKN45 cells and molecularly cloned its cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [hgf activator; hai-2]
<Options>: A: hepatocyte growth factor activator (mus musculus) (aka hepatocyte growth factor activator)
B: serpinf2 (homo sapiens) (aka serpin family f member 2)
C: hgfal (homo sapiens) (aka hyaluronan binding protein 2)
D: tfpi-2 (homo sapiens) (aka tissue factor pathway inhibitor 2... | [H; I] |
<Instruct>: Given the context 'In the present study, we purified a second type of HGF activator inhibitor (HAI-2) from the conditioned medium of MKN45 cells and molecularly cloned its cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [hgf activator; hai-2]
<Options>: A: hepatocyte growth factor (homo sapiens) (aka hepatocyte growth factor)
B: hgf activator (rattus norvegicus) (aka hgf activator)
C: serpinf2 (homo sapiens) (aka serpin family f member 2)
D: hepatocyte growth factor activator (mus musculus) (aka hepatocyte growth factor ac... | [G; E] |
<Instruct>: Given the context 'In the present study, we purified a second type of HGF activator inhibitor (HAI-2) from the conditioned medium of MKN45 cells and molecularly cloned its cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [hgf activator; hai-2]
<Options>: A: hai1 (homo sapiens) (aka serine peptidase inhibitor, kunitz type 1)
B: serpinf2 (homo sapiens) (aka serpin family f member 2)
C: hepatocyte growth factor activator (mus musculus) (aka hepatocyte growth factor activator)
D: hgf activator (rattus norvegicus) (aka hgf activ... | [J; E] |
<Instruct>: Given the context 'The cDNA sequence revealed that HAI-2 is derived from a precursor protein of 252 amino acids and contains two Kunitz domains, indicating that HAI-2 is also a member of the Kunitz family of serine protease inhibitors.', select the correct biomedical concept for each mention using the provi... | <Mentions>: [hai-2]
<Options>: A: hai-2 (homo sapiens) (aka serine peptidase inhibitor, kunitz type 2)
B: hcinf2 (homo sapiens) (aka solute carrier family 34 member 1)
C: serpinf2 (homo sapiens) (aka serpin family f member 2)
D: tfpi-2 (homo sapiens) (aka tissue factor pathway inhibitor 2)
E: hai1 (homo sapiens) (aka s... | [A] |
<Instruct>: Given the context 'The primary translation product of HAI-2 has a hydrophobic sequence in the COOH-terminal region, suggesting that, like HAI-1, HAI-2 is produced in a membrane-associated form and secreted in a proteolytically truncated form.', select the correct biomedical concept for each mention using th... | <Mentions>: [hai-2; hai-1]
<Options>: A: hcinf2 (homo sapiens) (aka solute carrier family 34 member 1)
B: haik1 (homo sapiens) (aka keratin 23)
C: inter-alpha-trypsin inhibitor heavy chain 2 (homo sapiens) (aka inter-alpha-trypsin inhibitor heavy chain 2)
D: hait1 (homo sapiens) (aka solute carrier family 71 member 1)
... | [F; I] |
<Instruct>: Given the context 'The primary translation product of HAI-2 has a hydrophobic sequence in the COOH-terminal region, suggesting that, like HAI-1, HAI-2 is produced in a membrane-associated form and secreted in a proteolytically truncated form.', select the correct biomedical concept for each mention using th... | <Mentions>: [hai-2; hai-1]
<Options>: A: inter-alpha-trypsin inhibitor heavy chain 2 (homo sapiens) (aka inter-alpha-trypsin inhibitor heavy chain 2)
B: haik1 (homo sapiens) (aka keratin 23)
C: hait1 (homo sapiens) (aka solute carrier family 71 member 1)
D: hai-1 (sus scrofa) (aka serine peptidase inhibitor, kunitz typ... | [E; H] |
<Instruct>: Given the context 'Because HAI-2 and HAI-1 are potent inhibitors specific for HGF activator, they may be involved in regulation of proteolytic activation of HGF in injured tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [hai-2; hai-1; hgf activator; hgf]
<Options>: A: serpinf2 (homo sapiens) (aka serpin family f member 2)
B: hgfl (homo sapiens) (macrophage stimulating 1 (homo sapiens)) (aka macrophage stimulating 1)
C: hgf3 (homo sapiens) (aka gingival fibromatosis, hereditary, 3)
D: hai (homo sapiens) (serine peptidase in... | [R; D; T; N] |
<Instruct>: Given the context 'Because HAI-2 and HAI-1 are potent inhibitors specific for HGF activator, they may be involved in regulation of proteolytic activation of HGF in injured tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [hai-2; hai-1; hgf activator; hgf]
<Options>: A: haip1 (homo sapiens) (aka baculoviral iap repeat containing 3)
B: hgfal (homo sapiens) (aka hyaluronan binding protein 2)
C: hgf5 (homo sapiens) (aka re1 silencing transcription factor)
D: haik1 (homo sapiens) (aka keratin 23)
E: hcinf2 (homo sapiens) (aka so... | [G; K; F; T] |
<Instruct>: Given the context 'Because HAI-2 and HAI-1 are potent inhibitors specific for HGF activator, they may be involved in regulation of proteolytic activation of HGF in injured tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [hai-2; hai-1; hgf activator; hgf]
<Options>: A: hgf3 (homo sapiens) (aka gingival fibromatosis, hereditary, 3)
B: haip1 (homo sapiens) (aka baculoviral iap repeat containing 3)
C: itih2 (homo sapiens) (aka inter-alpha-trypsin inhibitor heavy chain 2)
D: hgf5 (homo sapiens) (aka re1 silencing transcription ... | [L; P; E; G] |
<Instruct>: Given the context 'Because HAI-2 and HAI-1 are potent inhibitors specific for HGF activator, they may be involved in regulation of proteolytic activation of HGF in injured tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [hai-2; hai-1; hgf activator; hgf]
<Options>: A: hcinf2 (homo sapiens) (aka solute carrier family 34 member 1)
B: itih2 (homo sapiens) (aka inter-alpha-trypsin inhibitor heavy chain 2)
C: haik1 (homo sapiens) (aka keratin 23)
D: hai-2 (homo sapiens) (aka serine peptidase inhibitor, kunitz type 2)
E: hepatoc... | [I; L; K; E] |
<Instruct>: Given the context 'Glycogenin-2, a novel self-glucosylating protein involved in liver glycogen biosynthesis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glycogenin-2]
<Options>: A: glycogenin 2 (sus scrofa) (aka glycogenin 2)
B: glycogenin 2 (homo sapiens) (aka glycogenin 2)
C: glycogenin 2 (bos taurus) (aka glycogenin 2)
D: glycogenin 1 (homo sapiens) (aka glycogenin 1)
E: glycogenin 1 pseudogene 2 (homo sapiens) (aka glycogenin 1 pseudogene 2)
F: None of... | [B] |
<Instruct>: Given the context 'We describe the characterization of novel forms of glycogenin, designated glycogenin-2 (GN-2), encoded by a second gene that is expressed preferentially in certain tissues, including liver, heart, and pancreas.', select the correct biomedical concept for each mention using the provided op... | <Mentions>: [glycogenin-2; gn-2]
<Options>: A: glycogenin 1 (homo sapiens) (aka glycogenin 1)
B: glycogenin 1 pseudogene 2 (homo sapiens) (aka glycogenin 1 pseudogene 2)
C: glycogenin 2 (sus scrofa) (aka glycogenin 2)
D: gnb2 (homo sapiens) (aka g protein subunit beta 2)
E: gnt2 (homo sapiens) (aka alpha-1,6-mannosyl-g... | [G; G] |
<Instruct>: Given the context 'We describe the characterization of novel forms of glycogenin, designated glycogenin-2 (GN-2), encoded by a second gene that is expressed preferentially in certain tissues, including liver, heart, and pancreas.', select the correct biomedical concept for each mention using the provided op... | <Mentions>: [glycogenin-2; gn-2]
<Options>: A: gngt2 (homo sapiens) (aka g protein subunit gamma transducin 2)
B: glycogenin 2 pseudogene 2 (homo sapiens) (aka glycogenin 2 pseudogene 2)
C: gng2 (homo sapiens) (aka g protein subunit gamma 2)
D: glycogenin 2 (gallus gallus) (aka glycogenin 2)
E: g protein nucleolar 2 (h... | [H; H] |
<Instruct>: Given the context 'Cloning of cDNAs encoding glycogenin-2 indicated the existence of multiple species, including three liver forms (GN-2alpha, GN-2beta, and GN-2gamma) generated in part by alternative splicing.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [glycogenin-2; gn-2alpha; gn-2beta; gn-2gamma]
<Options>: A: glycogenin 2 (bos taurus) (aka glycogenin 2)
B: gnai2a (homo sapiens) (aka g protein subunit alpha i2 pseudogene 1)
C: gngt2 (homo sapiens) (aka g protein subunit gamma transducin 2)
D: gnt2 (homo sapiens) (aka alpha-1,6-mannosyl-glycoprotein 2-be... | [J; J; J; J] |
<Instruct>: Given the context 'Cloning of cDNAs encoding glycogenin-2 indicated the existence of multiple species, including three liver forms (GN-2alpha, GN-2beta, and GN-2gamma) generated in part by alternative splicing.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [glycogenin-2; gn-2alpha; gn-2beta; gn-2gamma]
<Options>: A: g protein subunit gamma 2 (homo sapiens) (aka g protein subunit gamma 2)
B: gnt2 (homo sapiens) (aka alpha-1,6-mannosyl-glycoprotein 2-beta-n-acetylglucosaminyltransferase)
C: gnat2 (homo sapiens) (aka g protein subunit alpha transducin 2)
D: gnai... | [O; O; O; O] |
<Instruct>: Given the context 'Cloning of cDNAs encoding glycogenin-2 indicated the existence of multiple species, including three liver forms (GN-2alpha, GN-2beta, and GN-2gamma) generated in part by alternative splicing.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [glycogenin-2; gn-2alpha; gn-2beta; gn-2gamma]
<Options>: A: glycogenin 1 pseudogene 2 (homo sapiens) (aka glycogenin 1 pseudogene 2)
B: gng5b (homo sapiens) (aka g protein subunit gamma 5b)
C: gnat2 (homo sapiens) (aka g protein subunit alpha transducin 2)
D: guanine nucleotide-binding protein subunit gamm... | [L; L; L; L] |
<Instruct>: Given the context 'Cloning of cDNAs encoding glycogenin-2 indicated the existence of multiple species, including three liver forms (GN-2alpha, GN-2beta, and GN-2gamma) generated in part by alternative splicing.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [glycogenin-2; gn-2alpha; gn-2beta; gn-2gamma]
<Options>: A: gng5b (homo sapiens) (aka g protein subunit gamma 5b)
B: guanine nucleotide binding protein (g protein), gamma 2 (xenopus tropicalis) (aka guanine nucleotide binding protein (g protein), gamma 2)
C: gnat2 (homo sapiens) (aka g protein subunit alph... | [F; F; F; F] |
<Instruct>: Given the context 'Cloning of cDNAs encoding glycogenin-2 indicated the existence of multiple species, including three liver forms (GN-2alpha, GN-2beta, and GN-2gamma) generated in part by alternative splicing.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [glycogenin-2; gn-2alpha; gn-2beta; gn-2gamma]
<Options>: A: gnb2 (homo sapiens) (aka g protein subunit beta 2)
B: g protein subunit gamma 2 (homo sapiens) (aka g protein subunit gamma 2)
C: glycogenin 1 pseudogene 2 (homo sapiens) (aka glycogenin 1 pseudogene 2)
D: gnt2 (homo sapiens) (aka alpha-1,6-mannos... | [H; H; H; H] |
<Instruct>: Given the context 'Overall, GN-2 has 40-45% identity to muscle glycogenin but is 72% identical over a 200-residue segment thought to contain the catalytic domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [gn-2; muscle glycogenin]
<Options>: A: glycogenin 1 (homo sapiens) (aka glycogenin 1)
B: gnp2 (homo sapiens) (aka glucosamine-6-phosphate deaminase 2)
C: liver glycogen phosphorylase (mus musculus) (aka liver glycogen phosphorylase)
D: glycogenin-1 (caenorhabditis elegans) (aka glycogenin-1)
E: gnt2 (homo ... | [J; A] |
<Instruct>: Given the context 'Overall, GN-2 has 40-45% identity to muscle glycogenin but is 72% identical over a 200-residue segment thought to contain the catalytic domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [gn-2; muscle glycogenin]
<Options>: A: glycogenin 1 (homo sapiens) (aka glycogenin 1)
B: gng2 (homo sapiens) (aka g protein subunit gamma 2)
C: gnt2 (homo sapiens) (aka alpha-1,6-mannosyl-glycoprotein 2-beta-n-acetylglucosaminyltransferase)
D: g protein nucleolar 2 (homo sapiens) (aka g protein nucleolar 2... | [J; A] |
<Instruct>: Given the context 'GN-2 expressed in Escherichia coli or COS cells is active in self-glucosylation assays, and self-glucosylated GN-2 can be elongated by skeletal muscle glycogen synthase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [gn-2; skeletal muscle glycogen synthase]
<Options>: A: glycogen [starch] synthase (caenorhabditis elegans) (aka glycogen [starch] synthase)
B: muscle glycogen phosphorylase (mus musculus) (aka muscle glycogen phosphorylase)
C: glycogen synthase 1 (homo sapiens) (aka glycogen synthase 1)
D: gna-2 (caenorhab... | [E; C] |
<Instruct>: Given the context 'GN-2 expressed in Escherichia coli or COS cells is active in self-glucosylation assays, and self-glucosylated GN-2 can be elongated by skeletal muscle glycogen synthase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [gn-2; skeletal muscle glycogen synthase]
<Options>: A: glycogen synthase 1 (xenopus tropicalis) (aka glycogen synthase 1)
B: glycogen synthase 2 (mus musculus) (aka glycogen synthase 2)
C: gngt2 (homo sapiens) (aka g protein subunit gamma transducin 2)
D: gnb2 (homo sapiens) (aka g protein subunit beta 2)
... | [F; G] |
<Instruct>: Given the context 'GN-2 expressed in Escherichia coli or COS cells is active in self-glucosylation assays, and self-glucosylated GN-2 can be elongated by skeletal muscle glycogen synthase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [gn-2; skeletal muscle glycogen synthase]
<Options>: A: glycogen synthase 2 (mus musculus) (aka glycogen synthase 2)
B: gnp2 (homo sapiens) (aka glucosamine-6-phosphate deaminase 2)
C: glycogenin 1 (mus musculus) (aka glycogenin 1)
D: glycogen synthase 1 (xenopus tropicalis) (aka glycogen synthase 1)
E: gnb... | [J; G] |
<Instruct>: Given the context 'Antibodies raised against GN-2 produced in E. coli recognized proteins of Mr approximately 66,000 present in extracts of rat liver and in cultured H4IIEC3 hepatoma cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [gn-2]
<Options>: A: g protein nucleolar 2 (homo sapiens) (aka g protein nucleolar 2)
B: gng2 (homo sapiens) (aka g protein subunit gamma 2)
C: gn2 (homo sapiens) (aka glycogenin 2)
D: gna-2 (caenorhabditis elegans) (aka glucosamine-phosphate n-acetyltransferase)
E: gnb2 (homo sapiens) (aka g protein subuni... | [C] |
<Instruct>: Given the context 'In H4IIEC3 cells, most of the GN-2 was present as a free protein but some was covalently associated with glycogen fractions and was only released by treatment with alpha-amylase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [gn-2]
<Options>: A: gnb2 (homo sapiens) (aka g protein subunit beta 2)
B: gngt2 (homo sapiens) (aka g protein subunit gamma transducin 2)
C: gna-2 (caenorhabditis elegans) (aka glucosamine-phosphate n-acetyltransferase)
D: gn2 (homo sapiens) (aka glycogenin 2)
E: g protein nucleolar 2 (homo sapiens) (aka g... | [D] |
<Instruct>: Given the context 'H4IIEC3 cells also expressed the muscle form of glycogenin (glycogenin-1), which was attached to a chromatographically separable glycogen fraction.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [muscle form of glycogenin; glycogenin-1]
<Options>: A: glycogenin 1 (homo sapiens) (aka glycogenin 1)
B: glycogenin 1 (mus musculus) (aka glycogenin 1)
C: muscle glycogen phosphorylase (mus musculus) (aka muscle glycogen phosphorylase)
D: glycogenin 1 (gallus gallus) (aka glycogenin 1)
E: glycogen synthase... | [A; A] |
<Instruct>: Given the context 'H4IIEC3 cells also expressed the muscle form of glycogenin (glycogenin-1), which was attached to a chromatographically separable glycogen fraction.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [muscle form of glycogenin; glycogenin-1]
<Options>: A: glycogenin 2 (homo sapiens) (aka glycogenin 2)
B: glycogenin 1 (rattus norvegicus) (aka glycogenin 1)
C: glycogen synthase 1 (homo sapiens) (aka glycogen synthase 1)
D: glycogenin-1 (gallus gallus) (aka glycogenin 1)
E: muscle glycogen phosphorylase (m... | [I; I] |
<Instruct>: Given the context 'hSK4, a member of a novel subfamily of calcium-activated potassium channels.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hsk4]
<Options>: A: map4k4 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 4)
B: huk4 (homo sapiens) (aka phospholipase d family member 3)
C: hbk4 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 4)
D: hsk4 (homo sapiens) (aka potassium calcium-activated chan... | [D] |
<Instruct>: Given the context 'The gene for hSK4, a novel human small conductance calcium-activated potassium channel, or SK channel, has been identified and expressed in Chinese hamster ovary cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [hsk4]
<Options>: A: ssk4 (saccharomyces cerevisiae s288c) (aka mitogen-activated protein kinase kinase pbs2)
B: hsk4 (homo sapiens) (aka potassium calcium-activated channel subfamily n member 4)
C: hbk4 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 4)
D: mapkk4 (homo sapiens) (aka ... | [B] |
<Instruct>: Given the context 'In physiological saline hSK4 generates a conductance of approximately 12 pS, a value in close agreement with that of other cloned SK channels.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [hsk4]
<Options>: A: ysk4 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase 19)
B: hbk4 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 4)
C: stk4 (homo sapiens) (aka serine/threonine kinase 4)
D: hsk4 (homo sapiens) (aka potassium calcium-activated channel subfamily ... | [D] |
<Instruct>: Given the context 'Like other members of this family, the polypeptide encoded by hSK4 contains a previously unnoted leucine zipper-like domain in its C terminus of unknown function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [hsk4]
<Options>: A: ssk4 (saccharomyces cerevisiae s288c) (aka mitogen-activated protein kinase kinase pbs2)
B: huk4 (homo sapiens) (aka phospholipase d family member 3)
C: hsk4 (homo sapiens) (aka potassium calcium-activated channel subfamily n member 4)
D: mekk4 (homo sapiens) (aka mitogen-activated prot... | [C] |
<Instruct>: Given the context 'Like other members of this family, the polypeptide encoded by hSK4 contains a previously unnoted leucine zipper-like domain in its C terminus of unknown function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [hsk4]
<Options>: A: ssk4 (saccharomyces cerevisiae s288c) (aka mitogen-activated protein kinase kinase pbs2)
B: huk4 (homo sapiens) (aka phospholipase d family member 3)
C: ysk4 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase 19)
D: mekk4 (homo sapiens) (aka mitogen-activated protein kin... | [E] |
<Instruct>: Given the context 'hSK4 appears unique, however, in its very high affinity for Ca2+ (EC50 of 95 nM) and its predominant expression in nonexcitable tissues of adult animals.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [hsk4]
<Options>: A: stk4 (homo sapiens) (aka serine/threonine kinase 4)
B: ysk4 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase 19)
C: mapkk4 (homo sapiens) (aka mitogen-activated protein kinase kinase 4)
D: hsk4 (homo sapiens) (aka potassium calcium-activated channel subfamily n member ... | [D] |
<Instruct>: Given the context 'Together with the relatively low homology of hSK4 to other SK channel polypeptides (approximately 40% identical), these data suggest that hSK4 belongs to a novel subfamily of SK channels.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [hsk4]
<Options>: A: serine/threonine kinase 4 (homo sapiens) (aka serine/threonine kinase 4)
B: hsk4 (homo sapiens) (aka potassium calcium-activated channel subfamily n member 4)
C: ysk4 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase 19)
D: map4k4 (homo sapiens) (aka mitogen-activated p... | [B] |
<Instruct>: Given the context 'Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [gm-csf/il-3/il-5 receptor common beta chain]
<Options>: A: colony stimulating factor 2 receptor subunit beta (bos taurus) (aka colony stimulating factor 2 receptor subunit beta)
B: colony stimulating factor 3 receptor (homo sapiens) (aka colony stimulating factor 3 receptor)
C: interleukin 2 receptor subun... | [E] |
<Instruct>: Given the context 'In some cases congenital PAP is associated with hereditary surfactant protein (SP)-B deficiency.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [surfactant protein (sp)-b]
<Options>: A: surfactant protein c (homo sapiens) (aka surfactant protein c)
B: surfactant protein b (bos taurus) (aka surfactant protein b)
C: sftp1b (homo sapiens) (surfactant protein a1 (homo sapiens)) (aka surfactant protein a1)
D: surfactant protein b (homo sapiens) (aka sur... | [D] |
<Instruct>: Given the context 'In mice, PAP has been generated by targeted deletion of the genes for either the GM-CSF/IL-3/IL-5 receptor common beta chain (beta c) or GM-CSF.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [gm-csf/il-3/il-5 receptor common beta chain; beta c]
<Options>: A: colony stimulating factor 2 receptor subunit beta (homo sapiens) (aka colony stimulating factor 2 receptor subunit beta)
B: beta-5 (homo sapiens) (aka tubulin beta 4a class iva)
C: il5r (homo sapiens) (aka interleukin 5 receptor subunit alp... | [A; A] |
<Instruct>: Given the context 'In mice, PAP has been generated by targeted deletion of the genes for either the GM-CSF/IL-3/IL-5 receptor common beta chain (beta c) or GM-CSF.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [gm-csf/il-3/il-5 receptor common beta chain; beta c]
<Options>: A: colony stimulating factor 3 receptor (homo sapiens) (aka colony stimulating factor 3 receptor)
B: colony stimulating factor 2 receptor subunit beta (sus scrofa) (aka colony stimulating factor 2 receptor subunit beta)
C: beta3 (homo sapiens)... | [G; G] |
<Instruct>: Given the context 'Here, we describe an expression defect of beta c in three of seven pediatric patients with PAP and in one patient with severe lung disease suspected to be PAP.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [beta c]
<Options>: A: propionyl-coa carboxylase subunit beta (homo sapiens) (aka propionyl-coa carboxylase subunit beta)
B: beta3 (homo sapiens) (aka basic helix-loop-helix family member e22)
C: betan (homo sapiens) (aka dna polymerase lambda)
D: g protein subunit beta 3 (homo sapiens) (aka g protein subun... | [F] |
<Instruct>: Given the context 'The patients failed to express normal levels of beta c as shown by flow cytometry.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta c]
<Options>: A: beta-3 (homo sapiens) (aka eukaryotic translation elongation factor 1 beta 2 pseudogene 2)
B: betan (homo sapiens) (aka dna polymerase lambda)
C: beta3b (homo sapiens) (aka basic helix-loop-helix family member e23)
D: betacellulin (homo sapiens) (aka betacellulin)
E: casein beta (homo... | [F] |
<Instruct>: Given the context 'Strikingly reduced or absent function of beta c was demonstrated by ligand binding studies and progenitor clonogenic assays.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [beta c]
<Options>: A: casein beta (homo sapiens) (aka casein beta)
B: propionyl-coa carboxylase subunit beta (homo sapiens) (aka propionyl-coa carboxylase subunit beta)
C: beta3b (homo sapiens) (aka basic helix-loop-helix family member e23)
D: beta-5 (homo sapiens) (aka tubulin beta 4a class iva)
E: g prot... | [F] |
<Instruct>: Given the context 'Analysis of beta c DNA revealed a point mutation from proline to threonine at codon 602 in one patient.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta c]
<Options>: A: betacellulin (homo sapiens) (aka betacellulin)
B: beta3 (homo sapiens) (aka basic helix-loop-helix family member e22)
C: propionyl-coa carboxylase subunit beta (homo sapiens) (aka propionyl-coa carboxylase subunit beta)
D: beta3b (homo sapiens) (aka basic helix-loop-helix family membe... | [F] |
<Instruct>: Given the context 'Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [quinolinate phosphoribosyltransferase]
<Options>: A: qprt (xenopus tropicalis) (aka quinolinate phosphoribosyltransferase)
B: quinolinate phosphoribosyltransferase (mus musculus) (aka quinolinate phosphoribosyltransferase)
C: quinolinate phosphoribosyltransferase (gallus gallus) (aka quinolinate phosphorib... | [E] |
<Instruct>: Given the context 'Mammalian quinolinate phosphoribosyltransferase (QPRTase) (EC 2.4.2.19) is a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [quinolinate phosphoribosyltransferase; qprtase]
<Options>: A: quinolinate phosphoribosyltransferase (oryctolagus cuniculus) (aka quinolinate phosphoribosyltransferase)
B: qprt (xenopus laevis) (aka quinolinate phosphoribosyltransferase l homeolog)
C: quinolinate phosphoribosyltransferase (bos taurus) (aka ... | [H; H] |
<Instruct>: Given the context 'Mammalian quinolinate phosphoribosyltransferase (QPRTase) (EC 2.4.2.19) is a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [quinolinate phosphoribosyltransferase; qprtase]
<Options>: A: quinolinate phosphoribosyltransferase (oryctolagus cuniculus) (aka quinolinate phosphoribosyltransferase)
B: qprt (xenopus tropicalis) (aka quinolinate phosphoribosyltransferase)
C: qprt (xenopus laevis) (aka quinolinate phosphoribosyltransferas... | [E; E] |
<Instruct>: Given the context 'As the first step to elucidate molecular basis underlying the quinolinate metabolism, the cDNA encoding human brain QPRTase was cloned and characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [qprtase]
<Options>: A: quinolinate phosphoribosyltransferase (decarboxylating) (escherichia coli str. k-12 substr. mg1655) (aka quinolinate phosphoribosyltransferase (decarboxylating))
B: glnq (escherichia coli str. k-12 substr. mg1655) (aka l-glutamine abc transporter atp binding subunit)
C: qprtase (mus ... | [D] |
<Instruct>: Given the context 'Utilizing partial amino acid sequences obtained from highly purified porcine kidney QPRTase, a human isolog was obtained from a human brain cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [qprtase]
<Options>: A: quinolinate phosphoribosyltransferase (decarboxylating) (escherichia coli str. k-12 substr. mg1655) (aka quinolinate phosphoribosyltransferase (decarboxylating))
B: quinolinate phosphoribosyltransferase (sus scrofa) (aka quinolinate phosphoribosyltransferase)
C: qprt (xenopus tropica... | [B] |
<Instruct>: Given the context 'To confirm that the cDNA clone encodes human QPRTase, its functional expression was studied in a bacterial host.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [qprtase]
<Options>: A: prophage antitermination protein q homolog quud (escherichia coli str. k-12 substr. mg1655) (aka prophage antitermination protein q homolog quud)
B: quinolinate phosphoribosyltransferase (decarboxylating) (escherichia coli str. k-12 substr. mg1655) (aka quinolinate phosphoribosyltran... | [C] |
<Instruct>: Given the context 'To confirm that the cDNA clone encodes human QPRTase, its functional expression was studied in a bacterial host.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [qprtase]
<Options>: A: quinolinate phosphoribosyltransferase (decarboxylating) (escherichia coli str. k-12 substr. mg1655) (aka quinolinate phosphoribosyltransferase (decarboxylating))
B: qprtase (mus musculus) (aka quinolinate phosphoribosyltransferase)
C: qprt (xenopus laevis) (aka quinolinate phosphorib... | [E] |
<Instruct>: Given the context 'Introduction of the human cDNA into a QPRTase defective (nadC) E. coli strain brought about an abrupt increase in QPRTase activity and allowed the cells to grow in the absence of nicotinic acid.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [qprtase; nadc]
<Options>: A: nadc1 (rattus norvegicus) (aka solute carrier family 13 member 2)
B: nuclear distribution c, dynein complex regulator (rattus norvegicus) (aka nuclear distribution c, dynein complex regulator)
C: prophage antitermination protein q homolog quud (escherichia coli str. k-12 substr... | [D; D] |
<Instruct>: Given the context 'Introduction of the human cDNA into a QPRTase defective (nadC) E. coli strain brought about an abrupt increase in QPRTase activity and allowed the cells to grow in the absence of nicotinic acid.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [qprtase; nadc]
<Options>: A: nedscac (homo sapiens) (aka mediator complex subunit 27)
B: nadc1 (homo sapiens) (aka solute carrier family 13 member 2)
C: qprtase (mus musculus) (aka quinolinate phosphoribosyltransferase)
D: quinolinate phosphoribosyltransferase (decarboxylating) (escherichia coli str. k-12 ... | [D; D] |
<Instruct>: Given the context 'It is concluded that the cloned cDNA encodes human QPRTase which is functional beyond the phylogenic boundary.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [qprtase]
<Options>: A: quinolinate phosphoribosyltransferase (sus scrofa) (aka quinolinate phosphoribosyltransferase)
B: glnq (escherichia coli str. k-12 substr. mg1655) (aka l-glutamine abc transporter atp binding subunit)
C: quinolinate phosphoribosyltransferase (homo sapiens) (aka quinolinate phosphorib... | [C] |
<Instruct>: Given the context 'Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tm4sf5]
<Options>: A: tm4sf8 (homo sapiens) (aka tetraspanin 3)
B: tm4sf6 (homo sapiens) (aka tetraspanin 6)
C: tm4sf5 (sus scrofa) (aka transmembrane 4 l six family member 5)
D: tm4sf5 (mus musculus) (aka transmembrane 4 superfamily member 5)
E: tm4sf5 (homo sapiens) (aka transmembrane 4 l six family memb... | [E] |
<Instruct>: Given the context 'In a previous large-scale screening for differentially expressed genes in pancreatic cancer, a gene was identified that was highly overexpressed in pancreatic cancer encoding a novel putative tetraspan transmembrane protein highly homologous to the tumour-associated antigen L6.', select t... | <Mentions>: [tumour-associated antigen l6]
<Options>: A: cancer/testis antigen family 47 member a6 (homo sapiens) (aka cancer/testis antigen family 47 member a6)
B: rpl7ap6 (homo sapiens) (aka ribosomal protein l7a pseudogene 6)
C: paraneoplastic antigen-like protein 6a (homo sapiens) (aka paraneoplastic antigen-like p... | [D] |
<Instruct>: Given the context 'Using a radiation hybrid panel the identified human gene named TM4SF5 (transmembrane 4 superfamily member 5) was localized to chromosome 17 in the region 17p13.3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [tm4sf5; transmembrane 4 superfamily member 5]
<Options>: A: tm4sf5 (homo sapiens) (aka transmembrane 4 l six family member 5)
B: tm4sf4 (homo sapiens) (aka transmembrane 4 l six family member 4)
C: tetraspanin 4 (homo sapiens) (aka tetraspanin 4)
D: tm4sf5 (mus musculus) (aka transmembrane 4 superfamily me... | [A; A] |
<Instruct>: Given the context 'Using a radiation hybrid panel the identified human gene named TM4SF5 (transmembrane 4 superfamily member 5) was localized to chromosome 17 in the region 17p13.3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [tm4sf5; transmembrane 4 superfamily member 5]
<Options>: A: tm4sf4 (homo sapiens) (aka transmembrane 4 l six family member 4)
B: tm4sf5 (sus scrofa) (aka transmembrane 4 l six family member 5)
C: transmembrane 4 superfamily member 5 (mus musculus) (aka transmembrane 4 superfamily member 5)
D: tm4sf5 (xenop... | [H; H] |
<Instruct>: Given the context 'The cloned TM4SF5 cDNA has a 32bp 5'-untranslated region (UTR), a 591bp open reading frame (ORF) and a 85bp 3'UTR.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tm4sf5]
<Options>: A: tm4sf5 (xenopus tropicalis) (aka transmembrane 4 l six family member 5)
B: tm4sf10 (homo sapiens) (aka transmembrane protein 47)
C: tm4sf5 (homo sapiens) (aka transmembrane 4 l six family member 5)
D: tm4sf6 (homo sapiens) (aka tetraspanin 6)
E: tm4sf8 (homo sapiens) (aka tetraspanin ... | [C] |
<Instruct>: Given the context 'The predicted TM4SF5 protein with 197 amino acids contains three NH2-terminal hydrophobic transmembrane regions, followed by an extracellular hydrophilic domain containing two potential N-linked glycosylation sites and a COOH-terminal hydrophobic transmembrane region.', select the correct... | <Mentions>: [tm4sf5]
<Options>: A: tm4sf5 (homo sapiens) (aka transmembrane 4 l six family member 5)
B: tm4sf5 (mus musculus) (aka transmembrane 4 superfamily member 5)
C: tm4sf5 (xenopus tropicalis) (aka transmembrane 4 l six family member 5)
D: tm4sf10 (homo sapiens) (aka transmembrane protein 47)
E: tm4sf3 (homo sap... | [A] |
<Instruct>: Given the context 'These structural features are shared by the L6 antigen and a number of related cell surface proteins associated with cell growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [l6 antigen]
<Options>: A: l7rn6 (homo sapiens) (aka heat shock protein nuclear import factor hikeshi)
B: l6 (homo sapiens) (transmembrane 4 l six family member 1 (homo sapiens)) (aka transmembrane 4 l six family member 1)
C: ribosomal protein l6 pseudogene 6 (homo sapiens) (aka ribosomal protein l6 pseudog... | [B] |
<Instruct>: Given the context 'TM4SF5 was overexpressed in pancreatic cancer tissues as compared to both normal pancreas and chronic pancreatitis tissues, and was detected at high levels in other tumour tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [tm4sf5]
<Options>: A: tm4sf5 (homo sapiens) (aka transmembrane 4 l six family member 5)
B: tm4sf5 (xenopus tropicalis) (aka transmembrane 4 l six family member 5)
C: tm4sf10 (homo sapiens) (aka transmembrane protein 47)
D: tm4sf3 (homo sapiens) (aka tetraspanin 8)
E: tm4sf5 (mus musculus) (aka transmembran... | [A] |
<Instruct>: Given the context 'Although the precise function of TM4SF5 remains to be elucidated it may be useful in a clinical setting for tumour diagnosis and/or therapy.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [tm4sf5]
<Options>: A: tm4sf5 (homo sapiens) (aka transmembrane 4 l six family member 5)
B: tm4sf5 (sus scrofa) (aka transmembrane 4 l six family member 5)
C: tm4sf3 (homo sapiens) (aka tetraspanin 8)
D: tm4sf4 (homo sapiens) (aka transmembrane 4 l six family member 4)
E: tm4sf (homo sapiens) (aka tetraspan... | [A] |
<Instruct>: Given the context 'This hypothesis is supported by the strong homology to the L6 antigen, which has proved promising in immunological, therapeutic and diagnostic approaches.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [l6 antigen]
<Options>: A: l6 (mus musculus) (transmembrane 4 superfamily member 1 (mus musculus)) (aka transmembrane 4 superfamily member 1)
B: l6 (drosophila melanogaster) (lethal (1) l6 (drosophila melanogaster)) (aka lethal (1) l6)
C: l7rn6 (homo sapiens) (aka heat shock protein nuclear import factor hi... | [D] |
<Instruct>: Given the context 'Triplet repeat-containing ribosomal protein L14 gene in immortalized human endothelial cell line (t-HUE4).
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ribosomal protein l14]
<Options>: A: l14 (drosophila melanogaster) (ribosomal protein l14 (drosophila melanogaster)) (aka ribosomal protein l14)
B: 50s ribosomal protein l14 (glycine max) (aka 50s ribosomal protein l14)
C: 60s ribosomal protein l14-like (homo sapiens) (aka 60s ribosomal protein l14-like)
D... | [D] |
<Instruct>: Given the context 'A cDNA encoding human 60S ribosomal subunit protein L14 (hRL14) was isolated from a human immortal endothelial cell line, t-HUE4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [ribosomal subunit protein l14; hrl14]
<Options>: A: bcl2l14 (homo sapiens) (aka bcl2 like 14)
B: ribosomal protein l14 (homo sapiens) (aka ribosomal protein l14)
C: ribosomal protein l14 pseudogene (homo sapiens) (aka ribosomal protein l14 pseudogene)
D: rpl14l (homo sapiens) (aka ribosomal protein l14 pse... | [B; B] |
<Instruct>: Given the context 'A cDNA encoding human 60S ribosomal subunit protein L14 (hRL14) was isolated from a human immortal endothelial cell line, t-HUE4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [ribosomal subunit protein l14; hrl14]
<Options>: A: bcl2l14 (homo sapiens) (aka bcl2 like 14)
B: arl14 (homo sapiens) (aka arf like gtpase 14)
C: hmettl14 (homo sapiens) (aka methyltransferase 14, n6-adenosine-methyltransferase non-catalytic subunit)
D: ribosomal protein l14 (mus musculus) (aka ribosomal p... | [I; I] |
<Instruct>: Given the context 'A cDNA encoding human 60S ribosomal subunit protein L14 (hRL14) was isolated from a human immortal endothelial cell line, t-HUE4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [ribosomal subunit protein l14; hrl14]
<Options>: A: mrp-l14 (homo sapiens) (mitochondrial ribosomal protein l14 (homo sapiens)) (aka mitochondrial ribosomal protein l14)
B: arl14 (homo sapiens) (aka arf like gtpase 14)
C: l14 (drosophila melanogaster) (ribosomal protein l14 (drosophila melanogaster)) (aka ... | [E; E] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.