instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
|---|---|---|
<Instruct>: Given the context 'The 3' UTR of the candidate gene contains a region of antisense complementarity to the 3' UTR of the ferritin heavy-chain gene (FTH1), indicating the possibility of antisense interaction between VMD2 and FTH1 transcripts.', select the correct biomedical concept for each mention using the ... | <Mentions>: [fth1; vmd2]
<Options>: A: fthp1 (homo sapiens) (aka ferritin heavy chain 1 pseudogene 5)
B: fth (homo sapiens) (aka ferritin heavy chain 1)
C: vmd2l2 (homo sapiens) (aka bestrophin 4)
D: vmd2 (homo sapiens) (aka bestrophin 1)
E: mvcd2 (homo sapiens) (aka erythropoietin)
F: fthfd (homo sapiens) (aka aldehyd... | [B; D] |
<Instruct>: Given the context 'BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain and is a component of the RNA polymerase II (Pol II) holoenzyme.', ... | <Mentions>: [brca1; rna helicase a; breast cancer specific tumour suppressor protein]
<Options>: A: ras homolog family member a (homo sapiens) (aka ras homolog family member a)
B: atp-dependent rna helicase a;rna helicase (caenorhabditis elegans) (aka atp-dependent rna helicase a;rna helicase)
C: brcaa1 (homo sapiens) ... | [F; K; F] |
<Instruct>: Given the context 'BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain and is a component of the RNA polymerase II (Pol II) holoenzyme.', ... | <Mentions>: [brca1; rna helicase a; breast cancer specific tumour suppressor protein]
<Options>: A: ras homolog family member a (homo sapiens) (aka ras homolog family member a)
B: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
C: breast cancer type 1 susceptibility protein ho... | [E; J; E] |
<Instruct>: Given the context 'BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain and is a component of the RNA polymerase II (Pol II) holoenzyme.', ... | <Mentions>: [brca1; rna helicase a; breast cancer specific tumour suppressor protein]
<Options>: A: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
B: brca1 dna repair associated (homo sapiens) (aka brca1 dna repair associated)
C: atp-dependent rna helicase a;rna helicase (caenorhabditis elegans) (aka atp-dep... | [B; J; B] |
<Instruct>: Given the context 'We show here that RNA helicase A (RHA) protein links BRCA1 to the holoenzyme complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rna helicase a; rha; brca1]
<Options>: A: dexh-box helicase 9 (homo sapiens) (aka dexh-box helicase 9)
B: rhna (homo sapiens) (aka rh blood group ccee antigens)
C: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
D: dexd-box helicase 39a (homo sapiens) (aka dexd-box helicase 39a)
E: brca1 d... | [A; A; E] |
<Instruct>: Given the context 'We show here that RNA helicase A (RHA) protein links BRCA1 to the holoenzyme complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rna helicase a; rha; brca1]
<Options>: A: rhd (homo sapiens) (aka rh blood group d antigen)
B: dexd-box helicase 39a (homo sapiens) (aka dexd-box helicase 39a)
C: dead-box helicase 1 (homo sapiens) (aka dead-box helicase 1)
D: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
E: brcaa1... | [N; N; I] |
<Instruct>: Given the context 'We show here that RNA helicase A (RHA) protein links BRCA1 to the holoenzyme complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rna helicase a; rha; brca1]
<Options>: A: ras homolog family member a (homo sapiens) (aka ras homolog family member a)
B: brca1 dna repair associated (homo sapiens) (aka brca1 dna repair associated)
C: rh associated glycoprotein (homo sapiens) (aka rh associated glycoprotein)
D: rhd (homo sapiens) (aka rh ... | [N; N; B] |
<Instruct>: Given the context 'We show here that RNA helicase A (RHA) protein links BRCA1 to the holoenzyme complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rna helicase a; rha; brca1]
<Options>: A: rhr (homo sapiens) (aka adrenoceptor beta 1)
B: ras homolog family member a (homo sapiens) (aka ras homolog family member a)
C: rh50a (homo sapiens) (aka rh associated glycoprotein)
D: dexd-box helicase 39a (homo sapiens) (aka dexd-box helicase 39a)
E: brca1 (homo ... | [H; H; E] |
<Instruct>: Given the context 'The region of BRCA1 which interacts with RHA and, thus, the holoenzyme complex, corresponds to subregions of the BRCT domain of BRCA1 (ref. 9).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [brca1; rha]
<Options>: A: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
B: rhfca (homo sapiens) (aka cytochrome p450 family 26 subfamily b member 1)
C: rhs (homo sapiens) (aka tumor protein p63)
D: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
E: brca1 promoter region (... | [F; J] |
<Instruct>: Given the context 'The region of BRCA1 which interacts with RHA and, thus, the holoenzyme complex, corresponds to subregions of the BRCT domain of BRCA1 (ref. 9).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [brca1; rha]
<Options>: A: brca1 (homo sapiens) (aka brca1 dna repair associated)
B: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
C: rhfca (homo sapiens) (aka cytochrome p450 family 26 subfamily b member 1)
D: brca1 pseudogene 1 (homo sapiens) (aka brca1 pseudog... | [A; H] |
<Instruct>: Given the context 'The region of BRCA1 which interacts with RHA and, thus, the holoenzyme complex, corresponds to subregions of the BRCT domain of BRCA1 (ref. 9).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [brca1; rha]
<Options>: A: brca1 (homo sapiens) (aka brca1 dna repair associated)
B: brca1 pseudogene 1 (homo sapiens) (aka brca1 pseudogene 1)
C: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
D: rhna (homo sapiens) (aka rh blood group ccee antigens)
E: breast ca... | [A; J] |
<Instruct>: Given the context 'This interaction was shown to occur in yeast nuclei, and expression in human cells of a truncated RHA molecule which retains binding to BRCA1 inhibited transcriptional activation mediated by the BRCA1 carboxy terminus.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [rha; brca1]
<Options>: A: brca1 dna repair associated (homo sapiens) (aka brca1 dna repair associated)
B: rhag (homo sapiens) (aka rh associated glycoprotein)
C: rhs (homo sapiens) (aka tumor protein p63)
D: rha (homo sapiens) (aka dexh-box helicase 9)
E: breast cancer type 1 susceptibility protein homolog... | [D; A] |
<Instruct>: Given the context 'This interaction was shown to occur in yeast nuclei, and expression in human cells of a truncated RHA molecule which retains binding to BRCA1 inhibited transcriptional activation mediated by the BRCA1 carboxy terminus.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [rha; brca1]
<Options>: A: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
B: rhfca (homo sapiens) (aka cytochrome p450 family 26 subfamily b member 1)
C: rhc (homo sapiens) (aka rh blood group ccee antigens)
D: rha (homo sapiens) (aka dexh-box helicase 9)
E: brca1 (homo sapiens) (aka brca1 dna re... | [D; E] |
<Instruct>: Given the context 'These data are the first to identify a specific protein interaction with the BRCA1 C-terminal domain and are consistent with the model that BRCA1 functions as a transcriptional coactivator.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [brca1]
<Options>: A: brca1p1 (homo sapiens) (aka brca1 pseudogene 1)
B: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
C: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
D: brca1 dna repair associated (homo sapiens) (aka brca1 dna repair as... | [D] |
<Instruct>: Given the context 'Recently, a suitable candidate gene, CNGA3, encoding the alpha-subunit of the cone photoreceptor cGMP-gated cation channel, a key component of the phototransduction pathway, has been cloned and assigned to human chromosome 2q11 (refs 3,4).', select the correct biomedical concept for each ... | <Mentions>: [cnga3]
<Options>: A: cnga3 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 3)
B: cnga4 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 4)
C: cnga3.l (xenopus laevis) (aka cyclic nucleotide gated channel alpha 3 l homeolog)
D: cnga3 (sus scrofa) (aka cyclic nucleotide gat... | [A] |
<Instruct>: Given the context 'We report the identification of missense mutations in CNGA3 in five families with RM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cnga3]
<Options>: A: cnga1 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 1)
B: cna3 (homo sapiens) (aka protein phosphatase 3 catalytic subunit gamma)
C: cnga3 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 3)
D: cnga2 (homo sapiens) (aka cyclic nucleotide gated chann... | [C] |
<Instruct>: Given the context 'The locus for the incomplete form of X-linked congenital stationary night blindness (CSNB2) maps to a 1.1-Mb region in Xp11.23 between markers DXS722 and DXS255.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [csnb2]
<Options>: A: csnb1 (homo sapiens) (aka nyctalopin)
B: csn1s2b (homo sapiens) (aka casein alpha s2 like b, pseudogene)
C: csn2 (bos taurus) (aka casein beta)
D: csnb2a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 f)
E: csnk2b (homo sapiens) (aka casein kinase 2 beta)
F: None of t... | [D] |
<Instruct>: Given the context 'We identified a retina-specific calcium channel alpha1-subunit gene (CACNA1F) in this region, consisting of 48 exons encoding 1966 amino acids and showing high homology to L-type calcium channel alpha1-subunits.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [cacna1f]
<Options>: A: cacna1f (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 f)
B: cacna1h (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 h)
C: cacna1f (rattus norvegicus) (aka calcium voltage-gated channel subunit alpha1 f)
D: cacna1f (xenopus laevis) (aka calcium chan... | [A] |
<Instruct>: Given the context 'Mutation analysis in 13 families with CSNB2 revealed nine different mutations in 10 families, including three nonsense and one frameshift mutation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [csnb2]
<Options>: A: csn1s2b (homo sapiens) (aka casein alpha s2 like b, pseudogene)
B: csn2 (bos taurus) (aka casein beta)
C: csnb2a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 f)
D: csnb1c (homo sapiens) (aka transient receptor potential cation channel subfamily m member 1)
E: csnk2b... | [C] |
<Instruct>: Given the context 'Mutation analysis in 13 families with CSNB2 revealed nine different mutations in 10 families, including three nonsense and one frameshift mutation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [csnb2]
<Options>: A: csn2 (bos taurus) (aka casein beta)
B: csnb1c (homo sapiens) (aka transient receptor potential cation channel subfamily m member 1)
C: csn1s2b (homo sapiens) (aka casein alpha s2 like b, pseudogene)
D: csnk2b (homo sapiens) (aka casein kinase 2 beta)
E: None of the above. | [E] |
<Instruct>: Given the context 'These data indicate that aberrations in a voltage-gated calcium channel, presumably causing a decrease in neurotransmitter release from photoreceptor presynaptic terminals, are a frequent cause of CSNB2.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [csnb2]
<Options>: A: csnk2b (homo sapiens) (aka casein kinase 2 beta)
B: csnb1b (homo sapiens) (aka glutamate metabotropic receptor 6)
C: csnbx2 (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 f)
D: csnb1 (homo sapiens) (aka nyctalopin)
E: csn2 (bos taurus) (aka casein beta)
F: None of the... | [C] |
<Instruct>: Given the context 'ZW10 helps recruit dynactin and dynein to the kinetochore.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [zw10]
<Options>: A: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_d2030.11 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
B: zw10 (homo sapiens) (aka zw10 kinetochore protein)
C: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (... | [B] |
<Instruct>: Given the context 'Mutations in the Drosophila melanogaster zw10 gene, which encodes a conserved, essential kinetochore component, abolish the ability of dynein to localize to kinetochores.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [zw10]
<Options>: A: zw10 (homo sapiens) (aka zw10 kinetochore protein)
B: zw10 (danio rerio) (aka zw10 kinetochore protein)
C: zw10 (xenopus tropicalis) (aka zw10 kinetochore protein)
D: zw10 (xenopus laevis) (zw10 kinetochore protein s homeolog (xenopus laevis)) (aka zw10 kinetochore protein s homeolog)
E... | [E] |
<Instruct>: Given the context 'Several similarities between the behavior of ZW10 protein and dynein further support a role for ZW10 in the recruitment of dynein to the kinetochore: (a) in response to bipolar tension across the chromosomes, both proteins mostly leave the kinetochore at metaphase, when their association ... | <Mentions>: [zw10]
<Options>: A: zw10 (homo sapiens) (aka zw10 kinetochore protein)
B: zw10 (danio rerio) (aka zw10 kinetochore protein)
C: zw10 (xenopus tropicalis) (aka zw10 kinetochore protein)
D: zw-10 (drosophila melanogaster) (aka zeste-white 10)
E: centromere/kinetochore protein zw10 homolog (caenorhabditis eleg... | [A] |
<Instruct>: Given the context 'ZW10's role in the recruitment of dynein to the kinetochore is likely to be reasonably direct, because dynamitin, the p50 subunit of the dynactin complex, interacts with ZW10 in a yeast two-hybrid screen.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [zw10; dynamitin]
<Options>: A: zw10 (danio rerio) (aka zw10 kinetochore protein)
B: dynamitin (danio rerio) (aka dynactin 2 (p50))
C: zw10 kinetochore protein s homeolog (xenopus laevis) (aka zw10 kinetochore protein s homeolog)
D: zw10 (homo sapiens) (aka zw10 kinetochore protein)
E: centromere/kinetochor... | [D; F] |
<Instruct>: Given the context 'ZW10's role in the recruitment of dynein to the kinetochore is likely to be reasonably direct, because dynamitin, the p50 subunit of the dynactin complex, interacts with ZW10 in a yeast two-hybrid screen.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [zw10; dynamitin]
<Options>: A: dynamitin (danio rerio) (aka dynactin 2 (p50))
B: dynamitin (homo sapiens) (aka dynactin subunit 2)
C: zw10 (drosophila melanogaster) (aka zeste-white 10)
D: dynamitin (xenopus laevis) (dynactin subunit 2 l homeolog (xenopus laevis)) (aka dynactin subunit 2 l homeolog)
E: p50... | [H; B] |
<Instruct>: Given the context 'Since in zw10 mutants no defects in chromosome behavior are observed before anaphase onset, our results suggest that dynein at the kinetochore is essential for neither microtubule capture nor congression to the metaphase plate.', select the correct biomedical concept for each mention usin... | <Mentions>: [zw10]
<Options>: A: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_f20d12.4 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
B: l(1)zw10 (drosophila melanogaster) (aka zeste-white 10)
C: zw10 (homo sapiens) (aka zw10 kinetochore protein)
D: centromere/... | [C] |
<Instruct>: Given the context 'The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations.
IFI 16 is an interferon-inducible nucleoprotein expressed by human monocytes.', select the correct biomedical concept fo... | <Mentions>: [ifn-inducible nucleoprotein ifi 16; ifi 16]
<Options>: A: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
B: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
C: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
D: ifi16 (mus musculus) (aka inte... | [E; E] |
<Instruct>: Given the context 'The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations.
IFI 16 is an interferon-inducible nucleoprotein expressed by human monocytes.', select the correct biomedical concept fo... | <Mentions>: [ifn-inducible nucleoprotein ifi 16; ifi 16]
<Options>: A: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
B: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
C: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
D: ifi16 (mus musculus) (aka interferon... | [C; C] |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [ifi 16; p202; p53; retinoblastoma gene product, prb]
<Options>: A: prb1 (homo sapiens) (rb transcriptional corepressor like 1 (homo sapiens)) (aka rb transcriptional corepressor like 1)
B: rad53 (homo sapiens) (aka checkpoint kinase 2)
C: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen... | [T; U; M; O] |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [ifi 16; p202; p53; retinoblastoma gene product, prb]
<Options>: A: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
B: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
C: p202 (homo sapiens) (aka tumor protein p53 binding protein 1)
D: p200b (homo sapiens) (aka heat repeat containin... | [A; U; M; T] |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [ifi 16; p202; p53; retinoblastoma gene product, prb]
<Options>: A: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
B: prb1 (homo sapiens) (rb transcriptional corepressor like 1 (homo sapiens)) (aka rb transcriptional corepressor like 1)
C: tp73 (homo sapiens) (aka tumor protein p73)
D: ifi16 ... | [P; U; G; O] |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [ifi 16; p202; p53; retinoblastoma gene product, prb]
<Options>: A: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
B: ct53 (homo sapiens) (aka zinc finger protein 165)
C: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
D: p202 (homo sapiens) (aka tumor protein p5... | [Q; U; T; S] |
<Instruct>: Given the context 'In this study, we examined IFI 16 expression in myeloid precursor cells cultured in vitro in colony-forming assays using granulocyte (G-) and granulocyte-macrophage (GM-) colony-stimulating factor (CSF).', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [ifi 16]
<Options>: A: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
B: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
C: ifi16 (mus musculus) (aka interferon activated gene 204)
D: glyi-16 (glycine max) (aka putative lac... | [B] |
<Instruct>: Given the context 'In this study, we examined IFI 16 expression in myeloid precursor cells cultured in vitro in colony-forming assays using granulocyte (G-) and granulocyte-macrophage (GM-) colony-stimulating factor (CSF).', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [ifi 16]
<Options>: A: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
B: ifi16 (mus musculus) (aka interferon activated gene 204)
C: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
D: glyi-16 (glycine max)... | [E] |
<Instruct>: Given the context 'IFI 16 was expressed in 100% of CD34+ cells isolated from human bone marrow.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16; cd34]
<Options>: A: cd34 molecule (homo sapiens) (aka cd34 molecule)
B: cd34 (sus scrofa) (aka cd34 molecule)
C: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
D: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
E: ifi16 (homo sapiens) (aka interferon gamma induci... | [E; A] |
<Instruct>: Given the context 'IFI 16 was expressed in 100% of CD34+ cells isolated from human bone marrow.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16; cd34]
<Options>: A: cd34 (sus scrofa) (aka cd34 molecule)
B: fat4 (homo sapiens) (aka fat atypical cadherin 4)
C: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
D: cd34 (gallus gallus) (aka cd34 molecule)
E: ifi16 (mus musculus) (aka interferon activated gene 204)
F: cd340 (homo sapi... | [H; G] |
<Instruct>: Given the context 'When the CD34+ cells were induced to differentiate, two sub-populations of cells were identified by two-color cytofluorography: the CD14+ (monocytoid) cells all expressed IFI 16, whereas the CD14- (polymorphonuclear precursor) cells did not.', select the correct biomedical concept for eac... | <Mentions>: [cd34; cd14; ifi 16]
<Options>: A: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
B: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
C: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
D: cd142 (homo sapiens) (aka coagulation factor iii, tissue factor)
E: transl... | [C; F; O] |
<Instruct>: Given the context 'When the CD34+ cells were induced to differentiate, two sub-populations of cells were identified by two-color cytofluorography: the CD14+ (monocytoid) cells all expressed IFI 16, whereas the CD14- (polymorphonuclear precursor) cells did not.', select the correct biomedical concept for eac... | <Mentions>: [cd34; cd14; ifi 16]
<Options>: A: cd344 (homo sapiens) (aka frizzled class receptor 4)
B: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
C: cd34 molecule (homo sapiens) (aka cd34 molecule)
D: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
E: nectin-4 (homo sapie... | [C; J; K] |
<Instruct>: Given the context 'When the CD34+ cells were induced to differentiate, two sub-populations of cells were identified by two-color cytofluorography: the CD14+ (monocytoid) cells all expressed IFI 16, whereas the CD14- (polymorphonuclear precursor) cells did not.', select the correct biomedical concept for eac... | <Mentions>: [cd34; cd14; ifi 16]
<Options>: A: cd34 molecule (homo sapiens) (aka cd34 molecule)
B: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
C: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
D: nectin-4 (homo sapiens) (aka ne... | [A; F; O] |
<Instruct>: Given the context 'When the CD34+ cells were induced to differentiate, two sub-populations of cells were identified by two-color cytofluorography: the CD14+ (monocytoid) cells all expressed IFI 16, whereas the CD14- (polymorphonuclear precursor) cells did not.', select the correct biomedical concept for eac... | <Mentions>: [cd34; cd14; ifi 16]
<Options>: A: cd34 (gallus gallus) (aka cd34 molecule)
B: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
C: cd140a (homo sapiens) (aka platelet derived growth factor receptor alpha)
D: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
E: cd142 (homo sapiens) (a... | [L; O; H] |
<Instruct>: Given the context 'The strongest expression of IFI 16 was in the cells staining brightest for CD14, whereas depletion of CD14+ monocytoid cells from mixed monocytic/granulocytic cultures largely abolished IFI 16-stained cells.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [ifi 16; cd14]
<Options>: A: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
B: cd140a (homo sapiens) (aka platelet derived growth factor receptor alpha)
C: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
D: cd142 (homo sapiens) (aka coagulation factor iii, tissue... | [I; G] |
<Instruct>: Given the context 'The strongest expression of IFI 16 was in the cells staining brightest for CD14, whereas depletion of CD14+ monocytoid cells from mixed monocytic/granulocytic cultures largely abolished IFI 16-stained cells.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [ifi 16; cd14]
<Options>: A: cd140a (homo sapiens) (aka platelet derived growth factor receptor alpha)
B: cd14 molecule (homo sapiens) (aka cd14 molecule)
C: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
D: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
E: ifi17 (homo sapien... | [H; B] |
<Instruct>: Given the context 'Furthermore, in eight independent colony-forming assays, the number of IFI 16+ cells correlated closely with the numbers of monocyte precursors identified morphologically (R2 = 0.99), but was unrelated to the numbers of myelocytes, promyelocytes, and metamyelocytes; nor was IFI 16 express... | <Mentions>: [ifi 16]
<Options>: A: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
B: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
C: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associa... | [A] |
<Instruct>: Given the context 'We conclude that IFI 16 is expressed in CD34+ and monocytoid daughter cells, but is rapidly and markedly down-regulated at the corresponding stages of polymorphonuclear and erythroid development.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [ifi 16; cd34]
<Options>: A: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
B: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
C: cd34 (gallus gallus) (aka cd34 molecule)
D: cd34 molecule (homo sapiens) (aka cd34 molecule)
E: ifi16 (mus musculus) (aka interferon activate... | [F; D] |
<Instruct>: Given the context 'We conclude that IFI 16 is expressed in CD34+ and monocytoid daughter cells, but is rapidly and markedly down-regulated at the corresponding stages of polymorphonuclear and erythroid development.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [ifi 16; cd34]
<Options>: A: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
B: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
C: cd34 (gallus gallus) (aka cd34 molecule)
D: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
E: glyi-16 (glycine max) (aka... | [I; J] |
<Instruct>: Given the context 'We conclude that IFI 16 is expressed in CD34+ and monocytoid daughter cells, but is rapidly and markedly down-regulated at the corresponding stages of polymorphonuclear and erythroid development.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [ifi 16; cd34]
<Options>: A: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
B: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
C: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
D: cd344 (homo sapiens) (aka frizzled class receptor 4)
E: cd34 (homo sapiens) (cd34 mole... | [A; E] |
<Instruct>: Given the context 'This differential expression of IFI 16 in myeloid precursor subpopulations and its perceived molecular properties are consistent with a possible role in regulating myelopoiesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sele... | <Mentions>: [ifi 16]
<Options>: A: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
B: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
C: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
D: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
E:... | [B] |
<Instruct>: Given the context 'A novel candidate oncogene, MCT-1, is involved in cell cycle progression.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1]
<Options>: A: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
B: solute carrier family 16 member 1 (homo sapiens) (aka solute carrier family 16 member 1)
C: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
D: slc16a5 (homo sapiens) (aka solute carrier family 16 member... | [C] |
<Instruct>: Given the context 'We termed this novel gene with multiple copies in a T-cell malignancy as MCT-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1]
<Options>: A: slc16a1 (homo sapiens) (aka solute carrier family 16 member 1)
B: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
C: slc16a6 (homo sapiens) (aka solute carrier family 16 member 6)
D: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
E: mct-1 (homo sapiens) (... | [E] |
<Instruct>: Given the context 'MCT-1 was localized to the long arm of chromosome Xq22-24 by flourescence in situ hybridization analysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1]
<Options>: A: solute carrier family 16 member 1 (homo sapiens) (aka solute carrier family 16 member 1)
B: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
C: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
D: slc16a2 (homo sapiens) (aka solute carrier family 16 member... | [B] |
<Instruct>: Given the context 'Although there was no significant homology at the primary sequence level, there was a limited degree of amino acid homology with a domain of cyclin H that appears to specify protein-protein complexes.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [cyclin h]
<Options>: A: ccnc (homo sapiens) (aka cyclin c)
B: p37 (homo sapiens) (cyclin h (homo sapiens)) (aka cyclin h)
C: cyclin h (gallus gallus) (aka cyclin h)
D: cyclin p (homo sapiens) (aka cyclin p)
E: cyclin g1 (homo sapiens) (aka cyclin g1)
F: None of the above. | [B] |
<Instruct>: Given the context 'This relationship between MCT-1 and cyclin H implied a potential role for MCT-1 in cell cycle regulation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1; cyclin h]
<Options>: A: solute carrier family 16 member 1 (homo sapiens) (aka solute carrier family 16 member 1)
B: cyclin c (homo sapiens) (aka cyclin c)
C: p37 (homo sapiens) (cyclin h (homo sapiens)) (aka cyclin h)
D: cyclin g1 (homo sapiens) (aka cyclin g1)
E: mct-1 (homo sapiens) (aka mcts1 re-... | [E; C] |
<Instruct>: Given the context 'This relationship between MCT-1 and cyclin H implied a potential role for MCT-1 in cell cycle regulation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1; cyclin h]
<Options>: A: cyclin p (homo sapiens) (aka cyclin p)
B: solute carrier family 16 member 1 (homo sapiens) (aka solute carrier family 16 member 1)
C: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
D: ccnc (homo sapiens) (aka cyclin c)
E: slc16a6 (homo sapiens) (aka solute car... | [H; J] |
<Instruct>: Given the context 'Overexpression of MCT-1 increased the proliferative rate of cells by decreasing the length of the G1 phase without a reciprocal increase in the S and G2-M phases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [mct-1]
<Options>: A: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
B: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
C: mct1 (homo sapiens) (solute carrier family 16 member 1 (homo sapiens)) (aka solute carrier family 16 member 1)
D: slc16a2 (homo sapiens) (aka solute ca... | [A] |
<Instruct>: Given the context 'Therefore, we investigated the transforming ability of MCT-1 overexpression using soft agar growth assays and demonstrated that only MCT-1-overexpressing cells were able to establish colonies.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [mct-1]
<Options>: A: slc16a6 (homo sapiens) (aka solute carrier family 16 member 6)
B: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
C: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
D: slc16a1 (homo sapiens) (aka solute carrier family 16 member 1)
E: mct-1 (homo sapiens) (... | [E] |
<Instruct>: Given the context 'Taken together, MCT-1 is a novel candidate oncogene with homology to a protein-protein binding domain of cyclin H.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1; cyclin h]
<Options>: A: slc16a1 (homo sapiens) (aka solute carrier family 16 member 1)
B: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
C: cyclin h (gallus gallus) (aka cyclin h)
D: cyclin h (homo sapiens) (aka cyclin h)
E: cyclin g1 (homo sapiens) (aka cyclin g1)
F: monocarboxyl... | [B; D] |
<Instruct>: Given the context 'Taken together, MCT-1 is a novel candidate oncogene with homology to a protein-protein binding domain of cyclin H.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1; cyclin h]
<Options>: A: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
B: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
C: cyclin g1 (homo sapiens) (aka cyclin g1)
D: p34 (homo sapiens) (cyclin h (homo sapiens)) (aka cyclin h)
E: mct (homo sapiens) (solute carrier... | [A; D] |
<Instruct>: Given the context 'Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [3alpha-hydroxysteroid dehydrogenase; akr1c3]
<Options>: A: akr1c3 (sus scrofa) (aka aldo-keto reductase family 1 member c3)
B: 2-alpha-hsd (homo sapiens) (aka aldo-keto reductase family 1 member c1)
C: hydroxysteroid 17-beta dehydrogenase 3 (homo sapiens) (aka hydroxysteroid 17-beta dehydrogenase 3)
D: akr... | [I; I] |
<Instruct>: Given the context 'Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [3alpha-hydroxysteroid dehydrogenase; akr1c3]
<Options>: A: 7-dehydrocholesterol reductase (homo sapiens) (aka 7-dehydrocholesterol reductase)
B: 17-beta-hsd (homo sapiens) (aka hydroxysteroid 17-beta dehydrogenase 1)
C: hsd3b1 (homo sapiens) (aka hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid d... | [G; G] |
<Instruct>: Given the context 'Human 3alpha-hydroxysteroid dehydrogenase exists in four isoforms, which belong to the aldo-keto reductase (AKR) superfamily and are named AKR1C1-AKR1C4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [3alpha-hydroxysteroid dehydrogenase]
<Options>: A: 3alpha-hsd (xenopus tropicalis) (aka dehydrogenase/reductase (sdr family) member 9)
B: 17-beta-hsd (homo sapiens) (aka hydroxysteroid 17-beta dehydrogenase 1)
C: 3alpha-hsd (homo sapiens) (aka dehydrogenase/reductase 9)
D: 2-alpha-hsd (homo sapiens) (aka a... | [F] |
<Instruct>: Given the context 'The properties of AKR1C3 have not been fully characterized compared to the other isoforms.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [akr1c3]
<Options>: A: akr1b1 (homo sapiens) (aka aldo-keto reductase family 1 member b)
B: akr1c2 (homo sapiens) (aka aldo-keto reductase family 1 member c2)
C: akr1c3 (sus scrofa) (aka aldo-keto reductase family 1 member c3)
D: akr1b3 (mus musculus) (aka aldo-keto reductase family 1 member b)
E: akr1c3 (h... | [E] |
<Instruct>: Given the context 'In addition, a cDNA that shows more than 99% homology with AKR1C3 cDNA has been cloned from human myeloblasts.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [akr1c3]
<Options>: A: akr1c3 (rattus norvegicus) (aka aldo-keto reductase family 1, member c3)
B: akr1b3 (mus musculus) (aka aldo-keto reductase family 1 member b)
C: akr1c-pseudo (homo sapiens) (aka aldo-keto reductase family 1 member c2)
D: akr7a3 (homo sapiens) (aka aldo-keto reductase family 7 member a... | [E] |
<Instruct>: Given the context 'The recombinant AKR1C3 prepared by site-directed mutagenesis of DBDH also showed the same properties as the wild-type DBDH.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [akr1c3]
<Options>: A: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
B: akr7a3 (homo sapiens) (aka aldo-keto reductase family 7 member a3)
C: akr1c1 (homo sapiens) (aka aldo-keto reductase family 1 member c1)
D: akr1c2 (homo sapiens) (aka aldo-keto reductase family 1 member c2)
E: akr1b... | [A] |
<Instruct>: Given the context 'Analyses of expression of mRNAs for DBDH and AKR1C3 by reverse transcription-PCR indicated that only one mRNA species for DBDH is expressed in 33 human specimens of liver, kidney, lung, brain, heart, spleen, adrenal gland, small intestine, placenta, prostate, and testis.', select the corr... | <Mentions>: [akr1c3]
<Options>: A: akr1c2 (homo sapiens) (aka aldo-keto reductase family 1 member c2)
B: akr1b3 (mus musculus) (aka aldo-keto reductase family 1 member b)
C: akr1c3 (sus scrofa) (aka aldo-keto reductase family 1 member c3)
D: akr1b1 (homo sapiens) (aka aldo-keto reductase family 1 member b)
E: akr1c3 (h... | [E] |
<Instruct>: Given the context 'These results suggest that AKR1C3 acts as prostaglandin D2 11-ketoreductase, and that its principal gene in the human has a coding region represented by DBDH cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [akr1c3]
<Options>: A: akr1c3 (rattus norvegicus) (aka aldo-keto reductase family 1, member c3)
B: akr1b3 (mus musculus) (aka aldo-keto reductase family 1 member b)
C: akr1b1 (homo sapiens) (aka aldo-keto reductase family 1 member b)
D: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
E: a... | [D] |
<Instruct>: Given the context 'In this study, we have identified a previously unclassified aldoketoreductase family member (termed HAKR e) that is expressed in HL60 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [hakr e]
<Options>: A: ackr2 (homo sapiens) (aka atypical chemokine receptor 2)
B: hakra (homo sapiens) (aka aldo-keto reductase family 1 member c4)
C: ackr3 (homo sapiens) (aka atypical chemokine receptor 3)
D: ackr6 (homo sapiens) (aka pitpnm family member 3)
E: hakre (homo sapiens) (aka aldo-keto reducta... | [E] |
<Instruct>: Given the context 'HAKR e is dramatically and transiently up-regulated in HL60 cells within 24 h of exposure to ATRA, further supporting the proposition that a member(s) of this family of enzymes play(s) a role in controlling cell growth and/or differentiation.', select the correct biomedical concept for ea... | <Mentions>: [hakr e]
<Options>: A: hakrc (homo sapiens) (aka aldo-keto reductase family 1 member c1)
B: ackr2 (homo sapiens) (aka atypical chemokine receptor 2)
C: hakre (homo sapiens) (aka aldo-keto reductase family 1 member c3)
D: hbrek (homo sapiens) (aka lemur tyrosine kinase 2)
E: klkr (homo sapiens) (aka kallikre... | [C] |
<Instruct>: Given the context 'G protein-coupled receptors such as the receptors for bradykinin are present in low copy numbers in most natural cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [bradykinin]
<Options>: A: bradykinin (xenopus tropicalis) (aka bradykinin receptor b2)
B: kallikrein 1 (bos taurus) (aka kallikrein 1)
C: bradykinin receptor b1 (homo sapiens) (aka bradykinin receptor b1)
D: bk (homo sapiens) (aka kininogen 1)
E: kallikrein (homo sapiens) (aka kallikrein related peptidase ... | [D] |
<Instruct>: Given the context 'G protein-coupled receptors such as the receptors for bradykinin are present in low copy numbers in most natural cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [bradykinin]
<Options>: A: kallikrein 1 (bos taurus) (aka kallikrein 1)
B: kallikrein (homo sapiens) (aka kallikrein related peptidase 4)
C: bradykinin receptor b1 (homo sapiens) (aka bradykinin receptor b1)
D: bradykinin (xenopus tropicalis) (aka bradykinin receptor b2)
E: None of the above. | [E] |
<Instruct>: Given the context 'The B1 receptor failed to undergo ligand-induced phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [b1 receptor]
<Options>: A: npbwr1 (bos taurus) (aka neuropeptides b and w receptor 1)
B: b1bkr (homo sapiens) (aka bradykinin receptor b1)
C: adrb1r (homo sapiens) (aka adrenoceptor beta 1)
D: adhesion g protein-coupled receptor b1 (homo sapiens) (aka adhesion g protein-coupled receptor b1)
E: bradykinin r... | [B] |
<Instruct>: Given the context 'However the B2 receptor showed selective phosphorylation of a minor 38 kDa band and lack of phosphorylation of a dominant 33 kDa band, indicating that only a fraction of the receptor protein is functionally linked to the kinase pathway.', select the correct biomedical concept for each men... | <Mentions>: [b2 receptor]
<Options>: A: bkb1r (homo sapiens) (aka bradykinin receptor b1)
B: blr2 (homo sapiens) (aka c-c motif chemokine receptor 7)
C: bkr2 (homo sapiens) (aka bradykinin receptor b2)
D: bb2r (homo sapiens) (aka gastrin releasing peptide receptor)
E: adrb2r (homo sapiens) (aka adrenoceptor beta 2)
F: ... | [C] |
<Instruct>: Given the context 'Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 homolog, double strand break repair nuclease (bos taurus) (aka mre11 homolog, double strand break repair nuclease)
B: mre11 double strand break repair nuclease (homo sapiens) (aka mre11 double strand break repair nuclease)
C: or4c11b (mus musculus) (aka olfactory recepto... | [H; K] |
<Instruct>: Given the context 'Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
B: hsd11b (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
C: mre11 homolog, double strand break repair nuclease (bos taurus) (aka mre11 homolog, double strand break repair ... | [A; K] |
<Instruct>: Given the context 'The Saccharomyces cerevisiae MRE11 gene plays an important role in meiotic recombination, mitotic DNA repair and telomere maintenance.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separat... | <Mentions>: [mre11]
<Options>: A: mre11 (homo sapiens) (aka mre11 double strand break repair nuclease)
B: mre11 homolog, double strand break repair nuclease (bos taurus) (aka mre11 homolog, double strand break repair nuclease)
C: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka ... | [F] |
<Instruct>: Given the context 'We present the isolation of hMRE11B cDNA from a human HeLa cell cDNA library as an MRE11 homolog.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka meiotic recombination 11)
B: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory receptor family 8 subfamily b member 12b)
C: mre11 (drosophila melanogaster) ... | [H; K] |
<Instruct>: Given the context 'We present the isolation of hMRE11B cDNA from a human HeLa cell cDNA library as an MRE11 homolog.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
B: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
C: mre11 (drosophila melanogaster) (igf-ii mrna-binding protein (drosophila melanogaster)) (aka igf-ii ... | [A; K] |
<Instruct>: Given the context 'Compared to the previously identified hMRE11, hMRE11B contains an additional 84bp sequence that results in a 28 amino-acid insertion close to the C-terminus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [hmre11; hmre11b]
<Options>: A: or11h4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
B: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
C: pou domain, class 5, transcription factor 1, related sequence 11 (mus musculus) (aka pou domain, ... | [J; B] |
<Instruct>: Given the context 'Compared to the previously identified hMRE11, hMRE11B contains an additional 84bp sequence that results in a 28 amino-acid insertion close to the C-terminus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [hmre11; hmre11b]
<Options>: A: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
B: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
C: ccr4-not transcription complex, subunit 11 (mus musculus) (aka ccr4... | [J; G] |
<Instruct>: Given the context 'The expression pattern of hMRE11B in different tissues shows the presence of two mRNA species of approx.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b]
<Options>: A: or2h1b (mus musculus) (aka olfactory receptor family 2 subfamily h member 1b)
B: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
C: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfa... | [D] |
<Instruct>: Given the context 'Overexpression of hMRE11B does not complement the alkylation sensitivity of the mre11 null and temperature-sensitive mutant strains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
B: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
C: mre11 homolog, double strand break repair nuclease (bos taurus) ... | [G; K] |
<Instruct>: Given the context 'Overexpression of hMRE11B does not complement the alkylation sensitivity of the mre11 null and temperature-sensitive mutant strains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [hmre11b; mre11]
<Options>: A: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
B: mre11 homolog, double strand break repair nuclease (rattus norvegicus) (aka mre11 homolog, double strand break repair nuclease)
C: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamil... | [J; K] |
<Instruct>: Given the context 'Overexpression of hMRE11B does not complement the alkylation sensitivity of the mre11 null and temperature-sensitive mutant strains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 double strand break repair nuclease (homo sapiens) (aka mre11 double strand break repair nuclease)
B: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka meiotic recombination 11)
C: mre11 (drosophila melanogaster) (igf-ii mrna-bindi... | [J; J] |
<Instruct>: Given the context 'First, both Northern and Western analyses rule out the lack of hMRE11B transcription and/or translation in yeast.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b]
<Options>: A: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
B: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
C: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfam... | [A] |
<Instruct>: Given the context 'Second, we demonstrate that hMre11B, like the yeast Mre11 protein, dimerizes in vivo in a yeast two-hybrid system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
B: mre11 double strand break repair nuclease (homo sapiens) (aka mre11 double strand break repair nuclease)
C: mre11 (mus musculus) (aka mre11a homo... | [J; K] |
<Instruct>: Given the context 'Second, we demonstrate that hMre11B, like the yeast Mre11 protein, dimerizes in vivo in a yeast two-hybrid system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 (drosophila melanogaster) (igf-ii mrna-binding protein (drosophila melanogaster)) (aka igf-ii mrna-binding protein)
B: or11h4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
C: mre11 homolog, double strand break repair nuclease (bos taurus) (aka ... | [D; K] |
<Instruct>: Given the context 'This dimerization requires the C-terminal one-third of hMre11B protein, which includes the 28 amino acids absent in hMre11.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [hmre11b; hmre11]
<Options>: A: creme9 (homo sapiens) (aka cytokine receptor like factor 3)
B: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
C: olfactory receptor family 11 subfamily h member 4b (mus musculus) (aka olfactory receptor family 11 subfamily h membe... | [B; K] |
<Instruct>: Given the context 'This dimerization requires the C-terminal one-third of hMre11B protein, which includes the 28 amino acids absent in hMre11.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [hmre11b; hmre11]
<Options>: A: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
B: msrg-11 (homo sapiens) (aka spermatogenesis associated 17)
C: hbre1 (homo sapiens) (aka ring finger protein 20)
D: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily ... | [A; J] |
<Instruct>: Given the context 'However, hMre11B does not interact with Mre11, Rad50 and Xrs2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: x-ray repair cross complementing 2 (drosophila melanogaster) (aka x-ray repair cross complementing 2)
B: mre11 homolog, double strand break repair nuclease (bos taurus) (aka mre11 homolog, double strand break repair nuclease)
C: mre11 double strand break repair nu... | [J; U; O; S] |
<Instruct>: Given the context 'However, hMre11B does not interact with Mre11, Rad50 and Xrs2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: xrn2 (homo sapiens) (aka 5'-3' exoribonuclease 2)
B: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
C: mre11 (mus musculus) (aka mre11a homolog a, double strand break repair nuclease)
D:... | [N; U; F; Q] |
<Instruct>: Given the context 'However, hMre11B does not interact with Mre11, Rad50 and Xrs2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: rad50 (drosophila melanogaster) (aka rad50)
B: homolog of x-ray repair cross complementing 2 (arabidopsis thaliana) (aka homolog of x-ray repair cross complementing 2 (xrcc2))
C: or2h1b (mus musculus) (aka olfactory receptor family 2 subfamily h member 1b)
D: dna ... | [Q; U; N; R] |
<Instruct>: Given the context 'However, hMre11B does not interact with Mre11, Rad50 and Xrs2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: rad50 (saccharomyces cerevisiae s288c) (aka mrx complex dna-binding subunit)
B: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
C: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory recepto... | [B; U; A; E] |
<Instruct>: Given the context 'Hence, the lack of protein-protein interaction between hMre11B and the yeast Mre11, Rad50, and Xrs2 may explain the inability of hMRE11B to complement the yeast mre11 mutants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: rad50 (saccharomyces cerevisiae s288c) (aka mrx complex dna-binding subunit)
B: xrg2 (homo sapiens) (aka xk related x-linked)
C: rad50 (drosophila melanogaster) (aka rad50)
D: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory recepto... | [N; U; A; J] |
<Instruct>: Given the context 'Hence, the lack of protein-protein interaction between hMre11B and the yeast Mre11, Rad50, and Xrs2 may explain the inability of hMRE11B to complement the yeast mre11 mutants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka meiotic recombination 11)
B: dna repair protein rad50-like (xenopus tropicalis) (aka dna repair protein rad50-like)
C: mre11 (homo sapiens) (aka mre11 double strand break rep... | [I; U; D; L] |
<Instruct>: Given the context 'Hence, the lack of protein-protein interaction between hMre11B and the yeast Mre11, Rad50, and Xrs2 may explain the inability of hMRE11B to complement the yeast mre11 mutants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: rad-50 (drosophila melanogaster) (aka rad50)
B: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka meiotic recombination 11)
C: homolog of x-ray repair cross complementing 2 (arabidopsis thaliana) (aka homolog of x-ray repair... | [T; U; J; S] |
<Instruct>: Given the context 'Hence, the lack of protein-protein interaction between hMre11B and the yeast Mre11, Rad50, and Xrs2 may explain the inability of hMRE11B to complement the yeast mre11 mutants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: xrn2 (homo sapiens) (aka 5'-3' exoribonuclease 2)
B: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka meiotic recombination 11)
C: rad50 (saccharomyces cerevisiae s288c) (aka mrx complex dna-binding subunit)
D: rad50 (droso... | [Q; U; C; G] |
<Instruct>: Given the context 'Hence, the lack of protein-protein interaction between hMre11B and the yeast Mre11, Rad50, and Xrs2 may explain the inability of hMRE11B to complement the yeast mre11 mutants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 (mus musculus) (aka mre11a homolog a, double strand break repair nuclease)
B: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
C: hmre11b (homo sapiens) (aka mre11 homolog, double strand brea... | [C; K] |
<Instruct>: Given the context 'Hence, the lack of protein-protein interaction between hMre11B and the yeast Mre11, Rad50, and Xrs2 may explain the inability of hMRE11B to complement the yeast mre11 mutants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [hmre11b; mre11]
<Options>: A: olfactory receptor family 11 subfamily h member 4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
B: mre11 homolog, double strand break repair nuclease (rattus norvegicus) (aka mre11 homolog, double strand break repair nuclease)
C: or9m1b (mus musculus... | [G; K] |
<Instruct>: Given the context 'We rule out the hypothesis that the lack of interaction and, in turn of complementation, is due to the absence of sequence homology at the C-terminal domain of hMre11B compared to the yeast Mre11.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 homolog, double strand break repair nuclease (gallus gallus) (aka mre11 homolog, double strand break repair nuclease)
B: mre11 homolog, double strand break repair nuclease (rattus norvegicus) (aka mre11 homolog, double strand break repair nuclease)
C: mre11a homolog a, d... | [I; K] |
<Instruct>: Given the context 'We rule out the hypothesis that the lack of interaction and, in turn of complementation, is due to the absence of sequence homology at the C-terminal domain of hMre11B compared to the yeast Mre11.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 (mus musculus) (aka mre11a homolog a, double strand break repair nuclease)
B: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
C: mre11 homolog, double strand break repair nuclease (gallus gallus) (aka mre11 homolog, double strand break rep... | [D; K] |
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