instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'The exon-intron boundaries are found in positions identical to those determined for the previously described CA II, CA III, and CA VII genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [ca ii; ca iii; ca vii]
<Options>: A: carbonic anhydrase vii s homeolog (xenopus laevis) (aka carbonic anhydrase vii s homeolog)
B: caxiii (homo sapiens) (aka carbonic anhydrase 13)
C: cai2 (homo sapiens) (aka cyclin dependent kinase inhibitor 2a)
D: ca7 (gallus gallus) (aka carbonic anhydrase 7)
E: carboni... | [L; H; E] |
<Instruct>: Given the context 'The exon-intron boundaries are found in positions identical to those determined for the previously described CA II, CA III, and CA VII genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [ca ii; ca iii; ca vii]
<Options>: A: ca7 (gallus gallus) (aka carbonic anhydrase 7)
B: ca-vii (homo sapiens) (aka carbonic anhydrase 7)
C: carbonic anhydrase vii s homeolog (xenopus laevis) (aka carbonic anhydrase vii s homeolog)
D: caxiii (homo sapiens) (aka carbonic anhydrase 13)
E: carbonic anhydrase 2 ... | [E; H; B] |
<Instruct>: Given the context 'Like the CA VII gene, CA5 does not contain typical TATA and CAAT promoter elements in the 5' flanking region but does contain a TTTAA sequence 147 nucleotides upstream of the initiation codon.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [ca vii; ca5]
<Options>: A: ca-vii (homo sapiens) (aka carbonic anhydrase 7)
B: ca7 (gallus gallus) (aka carbonic anhydrase 7)
C: ca-viii (homo sapiens) (aka carbonic anhydrase 8)
D: carbonic anhydrase vii (xenopus tropicalis) (aka carbonic anhydrase vii)
E: ca7.5 (mus musculus) (aka dna segment, ca7.5)
F: ... | [A; F] |
<Instruct>: Given the context 'Like the CA VII gene, CA5 does not contain typical TATA and CAAT promoter elements in the 5' flanking region but does contain a TTTAA sequence 147 nucleotides upstream of the initiation codon.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [ca vii; ca5]
<Options>: A: ca7 (xenopus tropicalis) (aka carbonic anhydrase vii)
B: ca-vi (homo sapiens) (aka carbonic anhydrase 6)
C: putative carbonic anhydrase 5 (caenorhabditis elegans) (aka putative carbonic anhydrase 5)
D: ca5 (gallus gallus) (aka carbonic anhydrase 5a)
E: ca-viii (homo sapiens) (aka... | [F; H] |
<Instruct>: Given the context 'CA5 also contains a 12-bp GT-rich segment beginning 13 bp downstream of the polyadenylation signal in the 3' untranslated region of exon 7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [ca5]
<Options>: A: ca5 (gallus gallus) (aka carbonic anhydrase 5a)
B: carbonic anhydrase 5b (homo sapiens) (aka carbonic anhydrase 5b)
C: ca5a (homo sapiens) (aka carbonic anhydrase 5a)
D: ca5p (homo sapiens) (aka carbonic anhydrase 5a pseudogene 1)
E: putative carbonic anhydrase 5 (caenorhabditis elegans)... | [C] |
<Instruct>: Given the context 'CA5 also contains a 12-bp GT-rich segment beginning 13 bp downstream of the polyadenylation signal in the 3' untranslated region of exon 7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [ca5]
<Options>: A: carbonic anhydrase 5b (homo sapiens) (aka carbonic anhydrase 5b)
B: putative carbonic anhydrase 5 (caenorhabditis elegans) (aka putative carbonic anhydrase 5)
C: ca5p (homo sapiens) (aka carbonic anhydrase 5a pseudogene 1)
D: ca5 (gallus gallus) (aka carbonic anhydrase 5a)
E: None of the... | [E] |
<Instruct>: Given the context 'FISH analysis allowed CA5 to be assigned to chromosome 16q24.3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ca5]
<Options>: A: ca7.5 (mus musculus) (aka dna segment, ca7.5)
B: ca5p (homo sapiens) (aka carbonic anhydrase 5a pseudogene 1)
C: ca5 (gallus gallus) (aka carbonic anhydrase 5a)
D: ca5d (homo sapiens) (aka carbonic anhydrase 5a)
E: putative carbonic anhydrase 5 (caenorhabditis elegans) (aka putative carb... | [D] |
<Instruct>: Given the context 'Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca1]
<Options>: A: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
B: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
C: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka b... | [D] |
<Instruct>: Given the context 'Fragments corresponding to the broadly expressed gamma-tubulin and Ki antigen genes were identified.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ki antigen]
<Options>: A: marker of proliferation ki-67 (bos taurus) (aka marker of proliferation ki-67)
B: ki (homo sapiens) (aka proteasome activator subunit 3)
C: marker of proliferation ki-67 (homo sapiens) (aka marker of proliferation ki-67)
D: ki-1 (homo sapiens) (aka tnf receptor superfamily member ... | [B] |
<Instruct>: Given the context 'A full-length cDNA clone encoding a 117-amino-acid protein homologous to the rat ribosomal protein L34 was isolated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ribosomal protein l34]
<Options>: A: ribosomal protein l34 (bos taurus) (aka ribosomal protein l34)
B: ribosomal protein l34 (mus musculus) (aka ribosomal protein l34)
C: ribosomal protein l24 (homo sapiens) (aka ribosomal protein l24)
D: l34 (drosophila melanogaster) (ribosomal protein l34a (drosophila me... | [F] |
<Instruct>: Given the context 'Portions of genes with restricted patterns of expression were also obtained, including the previously characterized HSD17B1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [hsd17b1]
<Options>: A: hsd11b1 (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
B: hsd17b1p1 (homo sapiens) (aka hydroxysteroid 17-beta dehydrogenase 1 pseudogene 1)
C: hsd17b1 (homo sapiens) (aka hydroxysteroid 17-beta dehydrogenase 1)
D: hsd17b11 (homo sapiens) (aka hydroxysteroid 17-beta dehy... | [C] |
<Instruct>: Given the context 'A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hkv beta 1.3]
<Options>: A: kv-beta-2 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 2)
B: hkvbeta3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
C: kv-beta-3 (homo sapiens) (aka potassium voltage-gated channel subfamily ... | [B] |
<Instruct>: Given the context 'We report here a novel K+ channel beta-subunit cloned from human heart, hKv beta 1.3, that has 74-83% overall identity with previously cloned beta-subunits.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [hkv beta 1.3]
<Options>: A: hkvbeta2.1 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 2)
B: kvbeta1.3 (xenopus tropicalis) (aka potassium channel, voltage gated subfamily a regulatory beta subunit 1)
C: kv-beta-3 (homo sapiens) (aka potassium voltage-gated channel s... | [D] |
<Instruct>: Given the context 'Comparison of hKv beta 1.3 with the previously cloned hKv beta 3 and rKv beta 1 proteins indicates that the carboxyl-terminal 328 amino acids are identical, while unique variable length amino termini exist.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [hkv beta 1.3; hkv beta 3; rkv beta 1]
<Options>: A: kv-beta-3 (xenopus tropicalis) (aka potassium channel, voltage gated subfamily a regulatory beta subunit 3)
B: potassium channel, voltage gated subfamily a regulatory beta subunit 1 (xenopus tropicalis) (aka potassium channel, voltage gated subfamily a re... | [H; I; G] |
<Instruct>: Given the context 'Comparison of hKv beta 1.3 with the previously cloned hKv beta 3 and rKv beta 1 proteins indicates that the carboxyl-terminal 328 amino acids are identical, while unique variable length amino termini exist.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [hkv beta 1.3; hkv beta 3; rkv beta 1]
<Options>: A: k(vca)beta-1 (homo sapiens) (aka potassium calcium-activated channel subfamily m regulatory beta subunit 1)
B: potassium voltage-gated channel subfamily a regulatory beta subunit 1 (rattus norvegicus) (aka potassium voltage-gated channel subfamily a regul... | [L; G; B] |
<Instruct>: Given the context 'Comparison of hKv beta 1.3 with the previously cloned hKv beta 3 and rKv beta 1 proteins indicates that the carboxyl-terminal 328 amino acids are identical, while unique variable length amino termini exist.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [hkv beta 1.3; hkv beta 3; rkv beta 1]
<Options>: A: potassium voltage-gated channel subfamily a regulatory beta subunit 1 (rattus norvegicus) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
B: k(vca)beta-1 (homo sapiens) (aka potassium calcium-activated channel subfamily m regul... | [E; H; A] |
<Instruct>: Given the context 'Comparison of hKv beta 1.3 with the previously cloned hKv beta 3 and rKv beta 1 proteins indicates that the carboxyl-terminal 328 amino acids are identical, while unique variable length amino termini exist.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [hkv beta 1.3; hkv beta 3; rkv beta 1]
<Options>: A: hkvbeta2.1 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 2)
B: slo-beta-3 (homo sapiens) (aka potassium calcium-activated channel subfamily m regulatory beta subunit 3)
C: hkvb3 (homo sapiens) (aka potassium volta... | [C; E; I] |
<Instruct>: Given the context 'Co-expression of hKv beta 1.3 in Xenopus oocytes with the delayed rectifier hKv1.5 indicated that hKv beta 1.3 has unique functional effects.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [hkv beta 1.3; hkv1.5]
<Options>: A: kv-beta-3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 3)
B: kv5.1 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily f member 1)
C: kcnv1 (homo sapiens) (aka potassium voltage-gated channel modifier subfamil... | [G; E] |
<Instruct>: Given the context 'Co-expression of hKv beta 1.3 in Xenopus oocytes with the delayed rectifier hKv1.5 indicated that hKv beta 1.3 has unique functional effects.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [hkv beta 1.3; hkv1.5]
<Options>: A: potassium channel, subfamily v, member 1 (mus musculus) (aka potassium channel, subfamily v, member 1)
B: kv7.5 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 5)
C: k(v)1.5 (xenopus laevis) (potassium channel, voltage gated shaker related subfamil... | [G; E] |
<Instruct>: Given the context 'Co-expression of hKv beta 1.3 in Xenopus oocytes with the delayed rectifier hKv1.5 indicated that hKv beta 1.3 has unique functional effects.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [hkv beta 1.3; hkv1.5]
<Options>: A: kv-beta-3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 3)
B: k(v)1.5 (xenopus laevis) (potassium channel, voltage gated shaker related subfamily a, member 5 l homeolog (xenopus laevis)) (aka potassium channel, voltage gated shak... | [I; G] |
<Instruct>: Given the context 'Most notably, hKv beta 1.3 converted the Kv1.5 outwardly rectifying current voltage relationship to one showing strong inward rectification.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [hkv beta 1.3; kv1.5]
<Options>: A: kvb1.3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
B: kv5.1 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily f member 1)
C: hkvbeta2.2 (homo sapiens) (aka potassium voltage-gated channel subfamily a regu... | [A; E] |
<Instruct>: Given the context 'Most notably, hKv beta 1.3 converted the Kv1.5 outwardly rectifying current voltage relationship to one showing strong inward rectification.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [hkv beta 1.3; kv1.5]
<Options>: A: potassium channel, subfamily k, member 5 (mus musculus) (aka potassium channel, subfamily k, member 5)
B: kv7.5 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 5)
C: k(v)1.5 (xenopus laevis) (potassium channel, voltage gated shaker related subfamily... | [E; I] |
<Instruct>: Given the context 'De novo mutation of the myelin P0 gene in Dejerine-Sottas disease (hereditary motor and sensory neuropathy type III).
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myelin p0]
<Options>: A: ribosomal protein lateral stalk subunit p0 (mus musculus) (aka ribosomal protein lateral stalk subunit p0)
B: p0 (rattus norvegicus) (aka myelin protein zero)
C: p0 (homo sapiens) (myelin protein zero (homo sapiens)) (aka myelin protein zero)
D: ribosomal protein lateral stalk subu... | [C] |
<Instruct>: Given the context 'We have investigated the myelin P0 gene on chromosome 1 as a candidate gene in two sporadic cases with Dejerine-Sottas disease or hereditary motor and sensory neuropathy (HMSN) type III.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [myelin p0]
<Options>: A: p0 (homo sapiens) (myelin protein zero (homo sapiens)) (aka myelin protein zero)
B: p0 (mus musculus) (aka myelin protein zero)
C: p0 (drosophila melanogaster) (aka ribosomal protein lp0)
D: ribosomal protein lateral stalk subunit p0 (mus musculus) (aka ribosomal protein lateral st... | [A] |
<Instruct>: Given the context 'The results strongly suggest that a de novo dominant mutation of the P0 gene is responsible for at least some sporadic cases of Dejerine-Sottas disease.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [p0]
<Options>: A: p0 (homo sapiens) (myelin protein zero (homo sapiens)) (aka myelin protein zero)
B: ribosomal protein lateral stalk subunit p0 (rattus norvegicus) (aka ribosomal protein lateral stalk subunit p0)
C: p0 (drosophila melanogaster) (aka ribosomal protein lp0)
D: lp0 (xenopus laevis) (ribosoma... | [A] |
<Instruct>: Given the context 'Human serum biotinidase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [biotinidase]
<Options>: A: biotinidase (rattus norvegicus) (aka biotinidase)
B: biotinidase (homo sapiens) (aka biotinidase)
C: biotinidase (gallus gallus) (aka biotinidase)
D: biotinidase (oryctolagus cuniculus) (aka biotinidase)
E: biotinidase (sus scrofa) (aka biotinidase)
F: None of the above. | [B] |
<Instruct>: Given the context 'cDNA cloning, sequence, and characterization.
Biotinidase (EC 3.5.1.12) catalyzes the hydrolysis of biocytin, the product of biotin-dependent carboxylase degradation, to biotin and lysine.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [biotinidase]
<Options>: A: biotinase (bos taurus) (aka biotinidase)
B: biotinidase (rattus norvegicus) (aka biotinidase)
C: biotinidase (oryctolagus cuniculus) (aka biotinidase)
D: biotinidase (gallus gallus) (aka biotinidase)
E: biotinidase (homo sapiens) (aka biotinidase)
F: None of the above. | [E] |
<Instruct>: Given the context 'Biotinidase deficiency is an inherited metabolic disorder of biotin recycling that is characterized by neurological and cutaneous abnormalities, and can be successfully treated with biotin supplementation.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [biotinidase]
<Options>: A: biotinidase (gallus gallus) (aka biotinidase)
B: biotinidase (sus scrofa) (aka biotinidase)
C: biotinidase (bos taurus) (aka biotinidase)
D: biotinidase (mus musculus) (aka biotinidase)
E: biotinidase (homo sapiens) (aka biotinidase)
F: None of the above. | [E] |
<Instruct>: Given the context 'Biotinidase deficiency is an inherited metabolic disorder of biotin recycling that is characterized by neurological and cutaneous abnormalities, and can be successfully treated with biotin supplementation.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [biotinidase]
<Options>: A: biotinidase (gallus gallus) (aka biotinidase)
B: biotinidase (sus scrofa) (aka biotinidase)
C: biotinidase (mus musculus) (aka biotinidase)
D: biotinidase (bos taurus) (aka biotinidase)
E: None of the above. | [E] |
<Instruct>: Given the context 'Sequences of tryptic peptides of the purified human serum enzyme were used to design oligonucleotide primers for polymerase chain reaction amplification from human hepatic total RNA to generate putative biotinidase cDNA fragments.', select the correct biomedical concept for each mention u... | <Mentions>: [biotinidase]
<Options>: A: biotinidase (homo sapiens) (aka biotinidase)
B: biotinidase (rattus norvegicus) (aka biotinidase)
C: biotinidase (gallus gallus) (aka biotinidase)
D: biotinidase (xenopus laevis) (aka biotinidase l homeolog)
E: biotinidase (oryctolagus cuniculus) (aka biotinidase)
F: None of the ... | [A] |
<Instruct>: Given the context 'Comparison of the open reading frame with the known biotinidase tryptic peptides and recognition of the expressed protein encoded by this cDNA by monoclonal antibodies prepared against purified biotinidase demonstrated the identity of this cDNA.', select the correct biomedical concept for... | <Mentions>: [biotinidase]
<Options>: A: biotinidase (gallus gallus) (aka biotinidase)
B: biotinidase (xenopus laevis) (aka biotinidase l homeolog)
C: biotinidase (homo sapiens) (aka biotinidase)
D: biotinidase (rattus norvegicus) (aka biotinidase)
E: biotinidase (sus scrofa) (aka biotinidase)
F: None of the above. | [C] |
<Instruct>: Given the context 'Southern analyses suggested that biotinidase is a single copy gene and revealed that human cDNA probes hybridized to genomic DNA from mammals, but not from chicken or yeast.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [biotinidase]
<Options>: A: biotinidase (rattus norvegicus) (aka biotinidase)
B: biotinidase (homo sapiens) (aka biotinidase)
C: biotinidase (sus scrofa) (aka biotinidase)
D: biotinidase (xenopus tropicalis) (aka biotinidase)
E: biotinidase (xenopus laevis) (aka biotinidase l homeolog)
F: None of the above. | [B] |
<Instruct>: Given the context 'Northern analysis indicated the presence of biotinidase mRNA in human heart, brain, placenta, liver, lung, skeletal muscle, kidney, and pancreas.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [biotinidase]
<Options>: A: biotinidase (rattus norvegicus) (aka biotinidase)
B: biotinidase (xenopus laevis) (aka biotinidase l homeolog)
C: biotinidase (mus musculus) (aka biotinidase)
D: biotinidase (homo sapiens) (aka biotinidase)
E: biotinidase (sus scrofa) (aka biotinidase)
F: None of the above. | [D] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: grb2 (bos taurus) (aka growth factor receptor bound protein 2)
B: c3g (drosophila melanogaster) (c3g guanyl-nucleotide exchange factor (drosophila melanogaster)) (aka c3g guanyl-nucleotide exchange factor)
C: ashr1 (arabidopsis thaliana) (aka set domain group 37)
D: crk (... | [E; G; M; M] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: c3g (rattus norvegicus) (aka rap guanine nucleotide exchange factor 1)
B: crkii (homo sapiens) (aka crk proto-oncogene, adaptor protein)
C: ash1 (absent, small, or homeotic)-like s homeolog (xenopus laevis) (aka ash1 (absent, small, or homeotic)-like s homeolog)
D: c3g (d... | [K; B; I; I] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: grb2 related adaptor protein 2 (homo sapiens) (aka grb2 related adaptor protein 2)
B: complement c8 gamma chain (homo sapiens) (aka complement c8 gamma chain)
C: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1)
D: ash1-related protein 1 (arabidopsis thali... | [C; E; M; M] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: egfrbp-grb2 (homo sapiens) (aka growth factor receptor bound protein 2)
B: c1qg (homo sapiens) (aka complement c1q c chain)
C: grb2 (bos taurus) (aka growth factor receptor bound protein 2)
D: ash (drosophila melanogaster) (aka absent, small, or homeotic discs 1)
E: crkii... | [S; H; A; A] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: c3g (mus musculus) (aka rap guanine nucleotide exchange factor (gef) 1)
B: grb2 related adaptor protein 2 (homo sapiens) (aka grb2 related adaptor protein 2)
C: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1)
D: crk proto-oncogene, adaptor protein (homo ... | [C; D; S; S] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [crk; grb2; ash]
<Options>: A: grb2l (homo sapiens) (aka grb2 related adaptor protein 2)
B: grb2 (bos taurus) (aka growth factor receptor bound protein 2)
C: ash 1 (drosophila melanogaster) (aka absent, small, or homeotic discs 1)
D: v-crk avian sarcoma virus ct10 oncogene homolog (xenopus tropicalis) (aka ... | [E; M; M] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [crk; grb2; ash]
<Options>: A: egfrbp-grb2 (homo sapiens) (aka growth factor receptor bound protein 2)
B: grb2 (bos taurus) (aka growth factor receptor bound protein 2)
C: arabidopsis ash2 relative (arabidopsis thaliana) (aka trauco)
D: crk7 (homo sapiens) (aka cyclin dependent kinase 12)
E: grb2 related ad... | [K; A; A] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [crk; grb2; ash]
<Options>: A: ash (drosophila melanogaster) (aka absent, small, or homeotic discs 1)
B: v-crk avian sarcoma virus ct10 oncogene homolog (mus musculus) (aka v-crk avian sarcoma virus ct10 oncogene homolog)
C: grb2 related adaptor protein (homo sapiens) (aka grb2 related adaptor protein)
D: c... | [D; E; E] |
<Instruct>: Given the context 'Here another guanine nucleotide-releasing protein (GNRP), C3G, has been identified as a CRK SH3-binding protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk sh3-binding protein]
<Options>: A: crkii (xenopus laevis) (v-crk avian sarcoma virus ct10 oncogene homolog s homeolog (xenopus laevis)) (aka v-crk avian sarcoma virus ct10 oncogene homolog s homeolog)
B: c3g (drosophila melanogaster) (c3g guanyl-nucleotide exchange factor (drosophila melanogaster)... | [G; G] |
<Instruct>: Given the context 'Here another guanine nucleotide-releasing protein (GNRP), C3G, has been identified as a CRK SH3-binding protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk sh3-binding protein]
<Options>: A: crk (drosophila melanogaster) (crk oncogene (drosophila melanogaster)) (aka crk oncogene)
B: v-crk avian sarcoma virus ct10 oncogene homolog-like (xenopus tropicalis) (aka v-crk avian sarcoma virus ct10 oncogene homolog-like)
C: complement c8 gamma chain (homo sa... | [I; I] |
<Instruct>: Given the context 'The nucleotide sequence of a 4.1-kb C3G cDNA contains a 3.2-kb open reading frame encoding a 121-kDa protein, and antibodies against C3G have been shown to detect a protein of 130-140 kDa.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [c3g]
<Options>: A: c3g (drosophila melanogaster) (c3g guanyl-nucleotide exchange factor (drosophila melanogaster)) (aka c3g guanyl-nucleotide exchange factor)
B: complement c8 gamma chain (homo sapiens) (aka complement c8 gamma chain)
C: complement c3 (homo sapiens) (aka complement c3)
D: c3g (rattus norve... | [E] |
<Instruct>: Given the context 'The carboxyl terminus of C3G has a peptide sequence homologous to GNRPs for Ras, and the expression of this carboxyl terminus region suppresses the loss of CDC25 function in the yeast Saccharomyces cerevisiae.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [c3g; cdc25]
<Options>: A: complement c3 (homo sapiens) (aka complement c3)
B: cdc25c (homo sapiens) (aka cell division cycle 25c)
C: cdc25a (homo sapiens) (aka cell division cycle 25a)
D: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1)
E: c3g (drosophila melanogaster) (c3g guanyl-nucleoti... | [D; I] |
<Instruct>: Given the context 'The carboxyl terminus of C3G has a peptide sequence homologous to GNRPs for Ras, and the expression of this carboxyl terminus region suppresses the loss of CDC25 function in the yeast Saccharomyces cerevisiae.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [c3g; cdc25]
<Options>: A: cdc25d (xenopus laevis) (provisional ortholog of cell division cycle 25c l homeolog (xenopus laevis)) (aka provisional ortholog of cell division cycle 25c l homeolog)
B: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1)
C: complement c8 gamma chain (homo sapiens) (... | [B; G] |
<Instruct>: Given the context 'The C3G protein expressed in Escherichia coli binds to CRK and GRB2/ASH proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: grb2l (homo sapiens) (aka grb2 related adaptor protein 2)
B: c3g (drosophila melanogaster) (c3g guanyl-nucleotide exchange factor (drosophila melanogaster)) (aka c3g guanyl-nucleotide exchange factor)
C: crkii (homo sapiens) (aka crk proto-oncogene, adaptor protein)
D: as... | [G; C; L; L] |
<Instruct>: Given the context 'The C3G protein expressed in Escherichia coli binds to CRK and GRB2/ASH proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: ash1 related protein 1 (arabidopsis thaliana) (aka set domain group 26)
B: growth factor receptor bound protein 2 (homo sapiens) (aka growth factor receptor bound protein 2)
C: crk proto-oncogene, adaptor protein (homo sapiens) (aka crk proto-oncogene, adaptor protein)
D:... | [O; C; B; B] |
<Instruct>: Given the context 'The C3G protein expressed in Escherichia coli binds to CRK and GRB2/ASH proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: c3g (mus musculus) (aka rap guanine nucleotide exchange factor (gef) 1)
B: grb2 (bos taurus) (aka growth factor receptor bound protein 2)
C: crkii (xenopus laevis) (v-crk avian sarcoma virus ct10 oncogene homolog s homeolog (xenopus laevis)) (aka v-crk avian sarcoma virus... | [E; G; J; J] |
<Instruct>: Given the context 'The C3G protein expressed in Escherichia coli binds to CRK and GRB2/ASH proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: c3 (homo sapiens) (aka complement c3)
B: crk7 (homo sapiens) (aka cyclin dependent kinase 12)
C: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1)
D: grb2 associated binding protein 2 (homo sapiens) (aka grb2 associated binding protein 2)
E: crkii (xenopus... | [C; S; R; R] |
<Instruct>: Given the context 'The C3G protein expressed in Escherichia coli binds to CRK and GRB2/ASH proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: ash1-related 1 (arabidopsis thaliana) (aka set domain group 37)
B: ash1 related protein 1 (arabidopsis thaliana) (aka set domain group 26)
C: grb2-b (xenopus tropicalis) (aka growth factor receptor bound protein 2)
D: crk (drosophila melanogaster) (crk oncogene (drosophil... | [G; J; Q; Q] |
<Instruct>: Given the context 'Mutational analysis of C3G assigns the SH3 binding region to a 50-amino acid region containing a proline-rich sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [c3g]
<Options>: A: c3g (rattus norvegicus) (aka rap guanine nucleotide exchange factor 1)
B: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1)
C: c3g (drosophila melanogaster) (crossover suppressor on 3 of gowen (drosophila melanogaster)) (aka crossover suppressor on 3 of gowen)
D: c3g (mus... | [B] |
<Instruct>: Given the context 'The mRNAs of both the C3G and CRK proteins are expressed ubiquitously in human adult and fetal tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk]
<Options>: A: v-crk avian sarcoma virus ct10 oncogene homolog (xenopus tropicalis) (aka v-crk avian sarcoma virus ct10 oncogene homolog)
B: crk oncogene (drosophila melanogaster) (aka crk oncogene)
C: complement c8 gamma chain (homo sapiens) (aka complement c8 gamma chain)
D: crk (gallus gallus) ... | [J; I] |
<Instruct>: Given the context 'The mRNAs of both the C3G and CRK proteins are expressed ubiquitously in human adult and fetal tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk]
<Options>: A: c3g (drosophila melanogaster) (crossover suppressor on 3 of gowen (drosophila melanogaster)) (aka crossover suppressor on 3 of gowen)
B: v-crk avian sarcoma virus ct10 oncogene homolog (xenopus tropicalis) (aka v-crk avian sarcoma virus ct10 oncogene homolog)
C: c3g (drosophila mela... | [H; F] |
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [crk; c3g; grb2; ash]
<Options>: A: ash1 (absent, small, or homeotic)-like s homeolog (xenopus laevis) (aka ash1 (absent, small, or homeotic)-like s homeolog)
B: grb2 related adaptor protein 2 (homo sapiens) (aka grb2 related adaptor protein 2)
C: grb2 associated binding protein 2 (homo sapiens) (aka grb2 a... | [K; Q; M; M] |
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [crk; c3g; grb2; ash]
<Options>: A: c1qg (homo sapiens) (aka complement c1q c chain)
B: ashr1 (arabidopsis thaliana) (aka set domain group 37)
C: crkii (homo sapiens) (aka crk proto-oncogene, adaptor protein)
D: ash1 (absent, small, or homeotic)-like s homeolog (xenopus laevis) (aka ash1 (absent, small, or ... | [C; N; K; K] |
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [crk; c3g; grb2; ash]
<Options>: A: c3g (rattus norvegicus) (aka rap guanine nucleotide exchange factor 1)
B: arabidopsis ash2 relative (arabidopsis thaliana) (aka trauco)
C: complement c8 gamma chain (homo sapiens) (aka complement c8 gamma chain)
D: crk7 (homo sapiens) (aka cyclin dependent kinase 12)
E: g... | [O; J; S; S] |
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [crk; c3g; grb2; ash]
<Options>: A: grb2 associated binding protein 2 (homo sapiens) (aka grb2 associated binding protein 2)
B: crk (homo sapiens) (aka crk proto-oncogene, adaptor protein)
C: c3g (rattus norvegicus) (aka rap guanine nucleotide exchange factor 1)
D: grb2 (bos taurus) (aka growth factor recep... | [B; H; M; M] |
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [c3g]
<Options>: A: c3g (drosophila melanogaster) (crossover suppressor on 3 of gowen (drosophila melanogaster)) (aka crossover suppressor on 3 of gowen)
B: c3g (drosophila melanogaster) (c3g guanyl-nucleotide exchange factor (drosophila melanogaster)) (aka c3g guanyl-nucleotide exchange factor)
C: compleme... | [E] |
<Instruct>: Given the context 'A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4.
', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [p55cdc; cdc20; cdc4]
<Options>: A: dna replication licensing factor mcm-4 (caenorhabditis elegans) (aka dna replication licensing factor mcm-4)
B: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1)
C: cdc20 (homo sapiens) (aka cell division cycle 20)
D: p55cdc (xenopus tropicalis) (aka cell division cy... | [K; N; E] |
<Instruct>: Given the context 'A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4.
', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [p55cdc; cdc20; cdc4]
<Options>: A: cdc20/fzy (drosophila melanogaster) (aka fizzy)
B: p5cdh (homo sapiens) (aka aldehyde dehydrogenase 4 family member a1)
C: cdc4 (homo sapiens) (aka f-box and wd repeat domain containing 7)
D: cdc20a (homo sapiens) (aka cell division cycle 20)
E: cdc20b (homo sapiens) (aka... | [M; N; L] |
<Instruct>: Given the context 'A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4.
', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [p55cdc; cdc20; cdc4]
<Options>: A: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1)
B: p55cdc (homo sapiens) (aka cell division cycle 20)
C: cdc24 (saccharomyces cerevisiae s288c) (aka rho family guanine nucleotide exchange factor cdc24)
D: cdc20b (homo sapiens) (aka cell division cycle 20b)
E:... | [B; E; L] |
<Instruct>: Given the context 'A novel protein, p55CDC, has been identified in cycling mammalian cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p55cdc]
<Options>: A: p55cdc (mus musculus) (aka cell division cycle 20)
B: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1)
C: p55cdc (homo sapiens) (aka cell division cycle 20)
D: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1)
E: p5cdh (homo sapiens) (aka aldehyde dehydrogenase 4 fami... | [C] |
<Instruct>: Given the context 'The p55CDC protein appears to be essential for cell division, since transfection of antisense p55CDC cDNA into CHO cells resulted in isolation of only those cells which exhibited a compensatory increase in p55CDC transcripts in the sense orientation.', select the correct biomedical concep... | <Mentions>: [p55cdc]
<Options>: A: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1)
B: p5cdh (homo sapiens) (aka aldehyde dehydrogenase 4 family member a1)
C: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1)
D: p55cdc (homo sapiens) (aka cell division cycle 20)
E: p55cdc (xenopus tropicalis) (aka cell... | [D] |
<Instruct>: Given the context 'Immunoprecipitation of p55CDC yielded protein complexes with kinase activity which fluctuated during the cell cycle.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p55cdc]
<Options>: A: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1)
B: p55cdc (mus musculus) (aka cell division cycle 20)
C: p55cdc (homo sapiens) (aka cell division cycle 20)
D: protein phosphatase 2a regulatory subunit cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regu... | [C] |
<Instruct>: Given the context 'Since p55CDC does not have the conserved protein kinase domains, this activity must be due to one or more of the associated proteins in the immune complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [p55cdc]
<Options>: A: p55cdc (homo sapiens) (aka cell division cycle 20)
B: p55cdc (xenopus tropicalis) (aka cell division cycle 20)
C: cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regulatory subunit cdc55)
D: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1)
E: p5cdh (homo... | [A] |
<Instruct>: Given the context 'The highest levels of protein kinase activity were seen with alpha-casein and myelin basic protein as substrates and demonstrated a pattern of activity distinct from that described for the known cyclin-dependent cell division kinases.', select the correct biomedical concept for each menti... | <Mentions>: [myelin basic protein]
<Options>: A: mbp (homo sapiens) (myelin basic protein (homo sapiens)) (aka myelin basic protein)
B: myelin basic protein (xenopus tropicalis) (aka myelin basic protein)
C: myelin associated oligodendrocyte basic protein (homo sapiens) (aka myelin associated oligodendrocyte basic prot... | [A] |
<Instruct>: Given the context 'The highest levels of protein kinase activity were seen with alpha-casein and myelin basic protein as substrates and demonstrated a pattern of activity distinct from that described for the known cyclin-dependent cell division kinases.', select the correct biomedical concept for each menti... | <Mentions>: [myelin basic protein]
<Options>: A: myelin associated oligodendrocyte basic protein (homo sapiens) (aka myelin associated oligodendrocyte basic protein)
B: mbp (mus musculus) (myelin basic protein (mus musculus)) (aka myelin basic protein)
C: myelin basic protein (xenopus tropicalis) (aka myelin basic prot... | [E] |
<Instruct>: Given the context 'The p55CDC protein was also phosphorylated in dividing cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p55cdc]
<Options>: A: p55cdc (homo sapiens) (aka cell division cycle 20)
B: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1)
C: cell division cycle 25c (homo sapiens) (aka cell division cycle 25c)
D: p55cdc (xenopus tropicalis) (aka cell division cycle 20)
E: cdc55 (saccharomyces cerevisiae s28... | [A] |
<Instruct>: Given the context 'The amino acid sequence of p55CDC contains seven repeats homologous to the beta subunit of G proteins, and the highest degree of homology in these repeats was found with the Saccharomyces cerevisiae Cdc20 and Cdc4 proteins, which have been proposed to be involved in the formation of a fun... | <Mentions>: [p55cdc; cdc20; cdc4]
<Options>: A: cdc4 (candida albicans sc5314) (aka scf ubiquitin ligase complex subunit)
B: cdc20 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein cdc20)
C: cdc4 (saccharomyces cerevisiae s288c) (aka scf ubiquitin ligase complex subunit cdc4)
D: cdc... | [N; B; C] |
<Instruct>: Given the context 'The amino acid sequence of p55CDC contains seven repeats homologous to the beta subunit of G proteins, and the highest degree of homology in these repeats was found with the Saccharomyces cerevisiae Cdc20 and Cdc4 proteins, which have been proposed to be involved in the formation of a fun... | <Mentions>: [p55cdc; cdc20; cdc4]
<Options>: A: protein phosphatase 2a regulatory subunit cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regulatory subunit cdc55)
B: mcm4 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm4)
C: cdc20c (homo sapiens) (aka fizzy and cell divisio... | [I; J; L] |
<Instruct>: Given the context 'The amino acid sequence of p55CDC contains seven repeats homologous to the beta subunit of G proteins, and the highest degree of homology in these repeats was found with the Saccharomyces cerevisiae Cdc20 and Cdc4 proteins, which have been proposed to be involved in the formation of a fun... | <Mentions>: [p55cdc; cdc20; cdc4]
<Options>: A: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1)
B: mcm4 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm4)
C: scf ubiquitin ligase complex subunit cdc4 (saccharomyces cerevisiae s288c) (aka scf ubiquitin ligase complex subunit cdc4)
... | [M; I; C] |
<Instruct>: Given the context 'The amino acid sequence of p55CDC contains seven repeats homologous to the beta subunit of G proteins, and the highest degree of homology in these repeats was found with the Saccharomyces cerevisiae Cdc20 and Cdc4 proteins, which have been proposed to be involved in the formation of a fun... | <Mentions>: [p55cdc; cdc20; cdc4]
<Options>: A: protein phosphatase 2a regulatory subunit cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regulatory subunit cdc55)
B: cdc20p (homo sapiens) (aka cell division cycle 20 pseudogene 1)
C: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1)
D: cdc... | [I; O; E] |
<Instruct>: Given the context 'The G beta repeat has been postulated to mediate protein-protein interactions and, in p55CDC, may modulate its association with a unique cell cycle protein kinase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [p55cdc]
<Options>: A: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1)
B: p55cdc (mus musculus) (aka cell division cycle 20)
C: p5cdh (homo sapiens) (aka aldehyde dehydrogenase 4 family member a1)
D: p55cdc (homo sapiens) (aka cell division cycle 20)
E: cell division cycle 25c (homo sapiens) (aka cel... | [D] |
<Instruct>: Given the context 'These findings suggest that p55CDC is a component of the mammalian cell cycle mechanism.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p55cdc]
<Options>: A: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1)
B: cell division cycle 25c (homo sapiens) (aka cell division cycle 25c)
C: cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regulatory subunit cdc55)
D: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1... | [E] |
<Instruct>: Given the context 'In the present study, serum from a patient with Sjögren's syndrome was used to identify a novel autoantigen which was designated Ge-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [ge-1]
<Options>: A: ge-1 (xenopus tropicalis) (aka enhancer of mrna decapping 4)
B: ese-1 (homo sapiens) (aka e74 like ets transcription factor 3)
C: ge-1 (homo sapiens) (aka enhancer of mrna decapping 4)
D: gec1 (homo sapiens) (aka gaba type a receptor associated protein like 1)
E: esg1 (xenopus tropicali... | [C] |
<Instruct>: Given the context 'Using the patient's serum, a 4.8-kb cDNA encoding Ge-1 was identified.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ge-1]
<Options>: A: ese-1 (homo sapiens) (aka e74 like ets transcription factor 3)
B: ge-1 (xenopus laevis) (enhancer of mrna decapping 4 l homeolog (xenopus laevis)) (aka enhancer of mrna decapping 4 l homeolog)
C: ge-1 (xenopus laevis) (enhancer of mrna decapping 4 s homeolog (xenopus laevis)) (aka enhan... | [D] |
<Instruct>: Given the context 'Fusion proteins containing different portions of Ge-1 were used to identify a 58 amino acid immunoreactive region within the protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [ge-1]
<Options>: A: ge-1 (xenopus tropicalis) (aka enhancer of mrna decapping 4)
B: ge-1 (xenopus laevis) (enhancer of mrna decapping 4 s homeolog (xenopus laevis)) (aka enhancer of mrna decapping 4 s homeolog)
C: esg1 (xenopus tropicalis) (transducin like enhancer of split 1 (xenopus tropicalis)) (aka tra... | [D] |
<Instruct>: Given the context 'The presence of the NLS motif within the immunoreactive region of Ge-1 and other nuclear autoantigens suggests that the NLS may be a target of human autoantibodies.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [ge-1]
<Options>: A: ge1 (homo sapiens) (aka enhancer of mrna decapping 4)
B: ge-1 (xenopus tropicalis) (aka enhancer of mrna decapping 4)
C: ge-1 (xenopus laevis) (enhancer of mrna decapping 4 s homeolog (xenopus laevis)) (aka enhancer of mrna decapping 4 s homeolog)
D: ese-1 (homo sapiens) (aka e74 like e... | [A] |
<Instruct>: Given the context 'Like aquaporin 1 (AQP1, also known as CHIP, channel-forming integral membrane protein of 28 kDa), the deduced polypeptide has six putative transmembrane domains but lacks cysteines at the known mercury-sensitive sites.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [aquaporin 1; aqp1; chip; channel-forming integral membrane protein of 28 kda]
<Options>: A: e3 ubiquitin-protein ligase chip (caenorhabditis elegans) (aka e3 ubiquitin-protein ligase chip)
B: tmem28 (homo sapiens) (aka nalcn channel auxiliary factor 2)
C: aqp-1 (homo sapiens) (aka mindy lysine 48 deubiquit... | [O; O; O; O] |
<Instruct>: Given the context 'Like aquaporin 1 (AQP1, also known as CHIP, channel-forming integral membrane protein of 28 kDa), the deduced polypeptide has six putative transmembrane domains but lacks cysteines at the known mercury-sensitive sites.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [aquaporin 1; aqp1; chip; channel-forming integral membrane protein of 28 kda]
<Options>: A: putative ergosterol biosynthetic protein 28 homolog (caenorhabditis elegans) (aka putative ergosterol biosynthetic protein 28 homolog)
B: e3 ubiquitin-protein ligase chip (caenorhabditis elegans) (aka e3 ubiquitin-p... | [P; P; P; P] |
<Instruct>: Given the context 'Like aquaporin 1 (AQP1, also known as CHIP, channel-forming integral membrane protein of 28 kDa), the deduced polypeptide has six putative transmembrane domains but lacks cysteines at the known mercury-sensitive sites.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [aquaporin 1; aqp1; chip; channel-forming integral membrane protein of 28 kda]
<Options>: A: aqp0 (homo sapiens) (aka major intrinsic protein of lens fiber)
B: tmem28 (homo sapiens) (aka nalcn channel auxiliary factor 2)
C: aqp-1 (homo sapiens) (aka mindy lysine 48 deubiquitinase 4)
D: e3 ubiquitin-protein ... | [G; G; G; G] |
<Instruct>: Given the context 'Like aquaporin 1 (AQP1, also known as CHIP, channel-forming integral membrane protein of 28 kDa), the deduced polypeptide has six putative transmembrane domains but lacks cysteines at the known mercury-sensitive sites.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [aquaporin 1; aqp1; chip; channel-forming integral membrane protein of 28 kda]
<Options>: A: chi (drosophila melanogaster) (chip (drosophila melanogaster)) (aka chip)
B: aqpx1 (homo sapiens) (aka aquaporin 11)
C: aquaporin 1 (colton blood group) (homo sapiens) (aka aquaporin 1 (colton blood group))
D: aquap... | [C; C; C; C] |
<Instruct>: Given the context 'Like aquaporin 1 (AQP1, also known as CHIP, channel-forming integral membrane protein of 28 kDa), the deduced polypeptide has six putative transmembrane domains but lacks cysteines at the known mercury-sensitive sites.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [aquaporin 1; aqp1; chip; channel-forming integral membrane protein of 28 kda]
<Options>: A: tmem28 (homo sapiens) (aka nalcn channel auxiliary factor 2)
B: chip (arabidopsis thaliana) (aka carboxyl terminus of hsc70-interacting protein)
C: small integral membrane protein 28 (homo sapiens) (aka small integr... | [K; K; K; K] |
<Instruct>: Given the context 'Its distinctive expression pattern implicates this fourth mammalian member of the aquaporin water channel family (designated gene symbol, AQP4) as the osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.', select the correct biomedical... | <Mentions>: [aqp4]
<Options>: A: provisional ortholog of aquaporin 4 (xenopus tropicalis) (aka provisional ortholog of aquaporin 4)
B: aqp4 (oryctolagus cuniculus) (aka aquaporin 4)
C: aqp4 (mus musculus) (aka aquaporin 4)
D: aqp4 (danio rerio) (aka aquaporin 4)
E: aquaporin 4 (homo sapiens) (aka aquaporin 4)
F: None o... | [E] |
<Instruct>: Given the context 'Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [vasopressin]
<Options>: A: avp (rattus norvegicus) (aka arginine vasopressin)
B: arginine vasopressin (homo sapiens) (aka arginine vasopressin)
C: vasopressin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog)
D: vasopressin (sus scrofa) (aka vasopress... | [B] |
<Instruct>: Given the context 'Water excretion by the kidney is regulated by the peptide hormone vasopressin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vasopressin]
<Options>: A: vasopressin (sus scrofa) (aka vasopressin)
B: avp (homo sapiens) (arginine vasopressin (homo sapiens)) (aka arginine vasopressin)
C: vasopressin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog)
D: arginine vasopressin (xeno... | [B] |
<Instruct>: Given the context 'Vasopressin increases the water permeability of the renal collecting duct cells, allowing more water to be reabsorbed from collecting duct urine to blood.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [vasopressin]
<Options>: A: vasopressin (sus scrofa) (aka vasopressin)
B: avp (homo sapiens) (arginine vasopressin (homo sapiens)) (aka arginine vasopressin)
C: arginine vasopressin (rattus norvegicus) (aka arginine vasopressin)
D: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin)
E: vaso... | [B] |
<Instruct>: Given the context 'Recently, a molecular water channel (AQP-CD) has been cloned whose expression appears to be limited to the collecting duct.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [aqp-cd]
<Options>: A: aqp-cd (mus musculus) (aka aquaporin 2)
B: aqpcd (xenopus laevis) (aquaporin 2 l homeolog (xenopus laevis)) (aka aquaporin 2 l homeolog)
C: aqp-cd (homo sapiens) (aka aquaporin 2)
D: aqp-cd (oryctolagus cuniculus) (aka aquaporin 2)
E: aqp-cd (xenopus tropicalis) (aka aquaporin 2)
F: N... | [C] |
<Instruct>: Given the context 'Here, we test the hypothesis that vasopressin increases cellular water permeability by inducing exocytosis of AQP-CD-laden vesicles, transferring water channels from IVs to APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sele... | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: aqp-2 (oryctolagus cuniculus) (aka aquaporin 2)
B: aqp-cd (mus musculus) (aka aquaporin 2)
C: vasopressin (sus scrofa) (aka vasopressin)
D: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog)
E: arginine va... | [G; F] |
<Instruct>: Given the context 'Here, we test the hypothesis that vasopressin increases cellular water permeability by inducing exocytosis of AQP-CD-laden vesicles, transferring water channels from IVs to APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sele... | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: aqpcd (xenopus laevis) (aquaporin 2 l homeolog (xenopus laevis)) (aka aquaporin 2 l homeolog)
B: vasotocin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog)
C: arginine vasopressin (xenopus tropicalis) (aka arginine ... | [G; F] |
<Instruct>: Given the context 'Rat collecting ducts were perfused in vitro to determine water permeability and subcellular distribution of AQP-CD in the same tubules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [aqp-cd]
<Options>: A: aqpcd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeolog)
B: aqp-cd (xenopus tropicalis) (aka aquaporin 2)
C: aqp-cd (oryctolagus cuniculus) (aka aquaporin 2)
D: aqp-cd (mus musculus) (aka aquaporin 2)
E: aqp-cd (homo sapiens) (aka aquaporin 2)
F: N... | [E] |
<Instruct>: Given the context 'The collecting ducts were fixed for immunoelectron microscopy before, during, and after exposure to vasopressin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vasopressin]
<Options>: A: vasotocin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog)
B: avp (rattus norvegicus) (aka arginine vasopressin)
C: vasopressin (sus scrofa) (aka vasopressin)
D: arginine vasopressin (xenopus tropicalis) (aka arginine vasop... | [E] |
<Instruct>: Given the context 'Vasopressin exposure induced increases in water permeability and the absolute labeling density of AQP-CD in the APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin)
B: aqp-cd (mus musculus) (aka aquaporin 2)
C: arginine vasopressin (homo sapiens) (aka arginine vasopressin)
D: aqp-cd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeol... | [C; J] |
<Instruct>: Given the context 'Vasopressin exposure induced increases in water permeability and the absolute labeling density of AQP-CD in the APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: vasotocin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog)
B: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin)
C: aqpcd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2... | [I; F] |
<Instruct>: Given the context 'Furthermore, in response to vasopressin withdrawal, AQP-CD labeling density in the APM and the APM:IV labeling ratio decreased in parallel to a measured decrease in osmotic water permeability.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog)
B: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin)
C: arginine vasopressin (homo sapiens) (aka arginine vasopressin)
D: aqp-cd (xenop... | [C; J] |
<Instruct>: Given the context 'Furthermore, in response to vasopressin withdrawal, AQP-CD labeling density in the APM and the APM:IV labeling ratio decreased in parallel to a measured decrease in osmotic water permeability.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: aqp-cd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeolog)
B: avp (homo sapiens) (arginine vasopressin (homo sapiens)) (aka arginine vasopressin)
C: vasopressin (sus scrofa) (aka vasopressin)
D: vasopressin (xenopus laevis) (arginine va... | [B; I] |
<Instruct>: Given the context 'We conclude that vasopressin increases the water permeability of collecting duct cells by inducing a reversible translocation of AQP-CD water channels from IVs to the APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog)
B: aqp-cd (homo sapiens) (aka aquaporin 2)
C: arginine vasopressin (rattus norvegicus) (aka arginine vasopressin)
D: aqp-cd (xenopus laevis) (aquaporin 2 ... | [G; B] |
<Instruct>: Given the context 'We conclude that vasopressin increases the water permeability of collecting duct cells by inducing a reversible translocation of AQP-CD water channels from IVs to the APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin)
B: aqp-cd (mus musculus) (aka aquaporin 2)
C: aqp-cd (homo sapiens) (aka aquaporin 2)
D: aqpcd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeolog)
E: aqp-2 (oryctolagu... | [H; C] |
<Instruct>: Given the context 'Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [eaa4; glur6]
<Options>: A: eap4 (homo sapiens) (aka exosome component 6)
B: glua4 (homo sapiens) (aka glutamate ionotropic receptor ampa type subunit 4)
C: grg6 (homo sapiens) (aka tle family member 6, subcortical maternal complex member)
D: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate ty... | [D; D] |
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