instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'This antagonism relates partly to their ability to compete with Myc for the protein Max and for consensus DNA binding sites and to recruit transcriptional co-repressors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [myc; max]
<Options>: A: max (homo sapiens) (aka myc associated factor x)
B: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
C: basic helix-loop-helix (bhlh) dna-binding protein (glycin... | [G; A] |
<Instruct>: Given the context 'This antagonism relates partly to their ability to compete with Myc for the protein Max and for consensus DNA binding sites and to recruit transcriptional co-repressors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [myc; max]
<Options>: A: protein max-like (homo sapiens) (aka protein max-like)
B: max (drosophila melanogaster) (males absent on the first (drosophila melanogaster)) (aka males absent on the first)
C: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis vira... | [F; G] |
<Instruct>: Given the context 'Mad(Mxi1) proteins have been suggested to be essential in cellular growth control and/or in the induction and maintenance of the differentiated state.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [mxi1]
<Options>: A: mxi1 (homo sapiens) (aka max interactor 1, dimerization protein)
B: mxi (xenopus laevis) (max interactor 1, dimerization protein l homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein l homeolog)
C: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequen... | [A] |
<Instruct>: Given the context 'Consistent with these roles, mxi1 may be the tumour-suppressor gene that resides at region 24-26 of the long arm of chromosome 10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [mxi1]
<Options>: A: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
B: mx-1 (mus musculus) (aka mx dynamin-like gtpase 1)
C: mxi1 (homo sapiens) (aka max interactor 1, dimerization protein)
D: max interactor 1, dimerization protein (mus musculus) (aka max interactor 1, dimerizat... | [C] |
<Instruct>: Given the context 'Here we show that mice lacking Mxi1 exhibit progressive, multisystem abnormalities.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mxi1]
<Options>: A: mxi (xenopus laevis) (max interactor 1, dimerization protein s homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein s homeolog)
B: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
C: mx1 (homo sapiens) (aka mx dynamin like gtpase 1)
D: mxi (x... | [E] |
<Instruct>: Given the context 'These mice also show increased susceptibility to tumorigenesis either following carcinogen treatment or when also deficient in Ink4a.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [ink4a]
<Options>: A: ink4c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
B: ink4 (homo sapiens) (aka cyclin dependent kinase inhibitor 2a)
C: ink4b (homo sapiens) (aka cyclin dependent kinase inhibitor 2b)
D: cdkn4 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
E: ink4d (homo sapiens... | [F] |
<Instruct>: Given the context 'This cancer-prone phenotype may correlate with the enhanced ability of several mxi1-deficient cell types, including prostatic epithelium, to proliferate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [mxi1]
<Options>: A: mxi (homo sapiens) (aka max interactor 1, dimerization protein)
B: mxi (xenopus laevis) (max interactor 1, dimerization protein s homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein s homeolog)
C: max interactor 1, dimerization protein (mus musculus) (aka max interact... | [C] |
<Instruct>: Given the context 'Our results show that Mxi1 is involved in the homeostasis of differentiated organ systems, acts as a tumour suppressor in vivo, and engages the Myc network in a functionally relevant manner.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [mxi1; myc]
<Options>: A: mx1 (mus musculus) (aka mx dynamin-like gtpase 1)
B: mxi (homo sapiens) (aka max interactor 1, dimerization protein)
C: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
D: mxi1 (mus musculus) (aka max interactor 1, dimerization protein)
E: myc-like oncogene, s... | [B; C] |
<Instruct>: Given the context 'Our results show that Mxi1 is involved in the homeostasis of differentiated organ systems, acts as a tumour suppressor in vivo, and engages the Myc network in a functionally relevant manner.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [mxi1; myc]
<Options>: A: mxi (homo sapiens) (aka max interactor 1, dimerization protein)
B: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
C: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
D: mxi (xe... | [A; J] |
<Instruct>: Given the context 'Our results show that Mxi1 is involved in the homeostasis of differentiated organ systems, acts as a tumour suppressor in vivo, and engages the Myc network in a functionally relevant manner.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [mxi1; myc]
<Options>: A: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
B: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
C: mxi1 (homo sapiens) (aka max interactor 1, dimerization protein)
D: v-myc avian myelocytomatosis viral oncogene h... | [C; J] |
<Instruct>: Given the context 'DNA sequence and muscle-specific expression of human sarcosin transcripts.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sarcosin]
<Options>: A: sarcospan (mus musculus) (aka sarcospan)
B: sarcosin (homo sapiens) (aka kelch like family member 41)
C: sarcosin (danio rerio) (aka kelch-like family member 41b)
D: sarcospan (bos taurus) (aka sarcospan)
E: sarcospan (homo sapiens) (aka sarcospan)
F: None of the above. | [B] |
<Instruct>: Given the context 'Consequently, we have termed this novel human sequence sarcosin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sarcosin]
<Options>: A: sarcosin (homo sapiens) (aka kelch like family member 41)
B: sarcosin (mus musculus) (aka kelch-like 41)
C: sarcc (homo sapiens) (aka purinergic receptor p2y1)
D: sarcospan (mus musculus) (aka sarcospan)
E: sarcosin (rattus norvegicus) (aka kelch-like family member 41)
F: None of th... | [A] |
<Instruct>: Given the context 'Although novel, Southern hybridization analysis demonstrated that the sarcosin sequence has been conserved in several mammalian species.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [sarcosin]
<Options>: A: sarcosin (homo sapiens) (aka kelch like family member 41)
B: sarcosinemia autosomal recessive (mus musculus) (aka sarcosinemia autosomal recessive)
C: sarcospan (mus musculus) (aka sarcospan)
D: sarcospan (homo sapiens) (aka sarcospan)
E: sarcosin (rattus norvegicus) (aka kelch-like... | [A] |
<Instruct>: Given the context 'Best macular dystrophy (BMD), also known as vitelliform macular dystrophy (VMD2; OMIM 153700), is an autosomal dominant form of macular degeneration characterized by an abnormal accumulation of lipofuscin within and beneath the retinal pigment epithelium cells.', select the correct biomed... | <Mentions>: [vmd2]
<Options>: A: vmd2 (homo sapiens) (aka bestrophin 1)
B: mc4dn2 (homo sapiens) (aka synthesis of cytochrome c oxidase 2)
C: vmd2l3 (homo sapiens) (aka bestrophin 3)
D: vmd2l1 (homo sapiens) (aka bestrophin 2)
E: mvcd2 (homo sapiens) (aka erythropoietin)
F: None of the above. | [A] |
<Instruct>: Given the context 'In pursuit of the disease gene, we limited the minimum genetic region by recombination breakpoint analysis and mapped to this region a novel retina-specific gene (VMD2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [vmd2]
<Options>: A: vmd1 (homo sapiens) (aka vitelliform macular dystrophy, atypical)
B: vmd4 (homo sapiens) (aka interphotoreceptor matrix proteoglycan 1)
C: vmd2 (homo sapiens) (aka bestrophin 1)
D: vm2 (drosophila melanogaster) (aka visible mutation-2)
E: vmd2 (mus musculus) (aka bestrophin 1)
F: None o... | [C] |
<Instruct>: Given the context 'The 3' UTR of the candidate gene contains a region of antisense complementarity to the 3' UTR of the ferritin heavy-chain gene (FTH1), indicating the possibility of antisense interaction between VMD2 and FTH1 transcripts.', select the correct biomedical concept for each mention using the ... | <Mentions>: [fth1; vmd2]
<Options>: A: vmd2 (homo sapiens) (aka bestrophin 1)
B: fer1 (drosophila melanogaster) (ferritin 1 heavy chain homologue (drosophila melanogaster)) (aka ferritin 1 heavy chain homologue)
C: vm2 (drosophila melanogaster) (aka visible mutation-2)
D: fthfd (homo sapiens) (aka aldehyde dehydrogenas... | [F; A] |
<Instruct>: Given the context 'The 3' UTR of the candidate gene contains a region of antisense complementarity to the 3' UTR of the ferritin heavy-chain gene (FTH1), indicating the possibility of antisense interaction between VMD2 and FTH1 transcripts.', select the correct biomedical concept for each mention using the ... | <Mentions>: [fth1; vmd2]
<Options>: A: mvcd2 (homo sapiens) (aka erythropoietin)
B: vm2 (drosophila melanogaster) (aka visible mutation-2)
C: fer1 (drosophila melanogaster) (ferritin 1 heavy chain homologue (drosophila melanogaster)) (aka ferritin 1 heavy chain homologue)
D: fth1 (homo sapiens) (aka ferritin heavy chai... | [D; J] |
<Instruct>: Given the context 'BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain and is a component of the RNA polymerase II (Pol II) holoenzyme.', ... | <Mentions>: [brca1; rna helicase a; breast cancer specific tumour suppressor protein]
<Options>: A: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
B: ras homolog family member a (homo sapiens) (aka ras homolog family member a)
C: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
D: breas... | [I; E; I] |
<Instruct>: Given the context 'BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain and is a component of the RNA polymerase II (Pol II) holoenzyme.', ... | <Mentions>: [brca1; rna helicase a; breast cancer specific tumour suppressor protein]
<Options>: A: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
B: bcds1 (homo sapiens) (cancer, familial, with in vitro radioresistance (homo sapiens)) (aka cancer, familial, with in vitro radioresistance)
C: dexh-box ... | [E; C; E] |
<Instruct>: Given the context 'BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain and is a component of the RNA polymerase II (Pol II) holoenzyme.', ... | <Mentions>: [brca1; rna helicase a; breast cancer specific tumour suppressor protein]
<Options>: A: dexh-box helicase 9 (homo sapiens) (aka dexh-box helicase 9)
B: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
C: brca1p1 (homo sapiens) (aka brca1 pseudogene 1)
D: mex-3 rna binding family member a (ho... | [I; A; I] |
<Instruct>: Given the context 'BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain and is a component of the RNA polymerase II (Pol II) holoenzyme.', ... | <Mentions>: [brca1; rna helicase a; breast cancer specific tumour suppressor protein]
<Options>: A: dna helicase b (homo sapiens) (aka dna helicase b)
B: ras homolog family member a (homo sapiens) (aka ras homolog family member a)
C: bcds1 (homo sapiens) (cancer, familial, with in vitro radioresistance (homo sapiens)) ... | [K; J; K] |
<Instruct>: Given the context 'We show here that RNA helicase A (RHA) protein links BRCA1 to the holoenzyme complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rna helicase a; rha; brca1]
<Options>: A: atp-dependent rna helicase a;rna helicase (caenorhabditis elegans) (aka atp-dependent rna helicase a;rna helicase)
B: dna helicase b (homo sapiens) (aka dna helicase b)
C: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
D: rhfca (homo sapiens) (aka... | [N; N; E] |
<Instruct>: Given the context 'We show here that RNA helicase A (RHA) protein links BRCA1 to the holoenzyme complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rna helicase a; rha; brca1]
<Options>: A: ribosomal rna processing 7 homolog a (homo sapiens) (aka ribosomal rna processing 7 homolog a)
B: rhs (homo sapiens) (aka tumor protein p63)
C: brca1 (homo sapiens) (aka brca1 dna repair associated)
D: breast cancer type 1 susceptibility protein homolog;ring-type e... | [N; N; C] |
<Instruct>: Given the context 'We show here that RNA helicase A (RHA) protein links BRCA1 to the holoenzyme complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rna helicase a; rha; brca1]
<Options>: A: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
B: dna helicase b (homo sapiens) (aka dna helicase b)
C: brca1 dna repair associated (homo sapiens) (aka brca1 dna repair associated)
D: atp-dependent rna helicase a;rna helicase (caenorhabditis... | [L; L; C] |
<Instruct>: Given the context 'The region of BRCA1 which interacts with RHA and, thus, the holoenzyme complex, corresponds to subregions of the BRCT domain of BRCA1 (ref. 9).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [brca1; rha]
<Options>: A: rhna (homo sapiens) (aka rh blood group ccee antigens)
B: rhr (homo sapiens) (aka adrenoceptor beta 1)
C: rha (homo sapiens) (aka dexh-box helicase 9)
D: brca1 pseudogene 1 (homo sapiens) (aka brca1 pseudogene 1)
E: brca1 dna repair associated (homo sapiens) (aka brca1 dna repair ... | [E; C] |
<Instruct>: Given the context 'The region of BRCA1 which interacts with RHA and, thus, the holoenzyme complex, corresponds to subregions of the BRCT domain of BRCA1 (ref. 9).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [brca1; rha]
<Options>: A: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
B: rhfca (homo sapiens) (aka cytochrome p450 family 26 subfamily b member 1)
C: brca1 pseudogene 1 (homo sapiens) (aka brca1 pseudogene 1)
D: breast cancer type 1 susceptibility protein homo... | [J; I] |
<Instruct>: Given the context 'This interaction was shown to occur in yeast nuclei, and expression in human cells of a truncated RHA molecule which retains binding to BRCA1 inhibited transcriptional activation mediated by the BRCA1 carboxy terminus.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [rha; brca1]
<Options>: A: rhfca (homo sapiens) (aka cytochrome p450 family 26 subfamily b member 1)
B: brca1 (homo sapiens) (aka brca1 dna repair associated)
C: rhag (homo sapiens) (aka rh associated glycoprotein)
D: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
E: brca1 promoter region (homo s... | [F; B] |
<Instruct>: Given the context 'This interaction was shown to occur in yeast nuclei, and expression in human cells of a truncated RHA molecule which retains binding to BRCA1 inhibited transcriptional activation mediated by the BRCA1 carboxy terminus.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [rha; brca1]
<Options>: A: pseudo-brca1 (homo sapiens) (aka brca1 pseudogene 1)
B: rhs (homo sapiens) (aka tumor protein p63)
C: rhr (homo sapiens) (aka adrenoceptor beta 1)
D: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
E: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc an... | [G; J] |
<Instruct>: Given the context 'These data are the first to identify a specific protein interaction with the BRCA1 C-terminal domain and are consistent with the model that BRCA1 functions as a transcriptional coactivator.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [brca1]
<Options>: A: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
B: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
C: brca1 dna repair associated (homo sapiens) (aka brca1 dna repair associated)
D: pseudo-brca1 (homo sapiens) (aka brca1 pseudogene 1)
E: breast cancer type 1 ... | [C] |
<Instruct>: Given the context 'Recently, a suitable candidate gene, CNGA3, encoding the alpha-subunit of the cone photoreceptor cGMP-gated cation channel, a key component of the phototransduction pathway, has been cloned and assigned to human chromosome 2q11 (refs 3,4).', select the correct biomedical concept for each ... | <Mentions>: [cnga3]
<Options>: A: cnga3 (xenopus tropicalis) (aka cyclic nucleotide gated channel alpha 3)
B: cnga4 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 4)
C: cnga3.l (xenopus laevis) (aka cyclic nucleotide gated channel alpha 3 l homeolog)
D: cnga3 (mus musculus) (aka cyclic nucleotide gat... | [E] |
<Instruct>: Given the context 'We report the identification of missense mutations in CNGA3 in five families with RM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cnga3]
<Options>: A: cnga3.s (xenopus laevis) (aka cyclic nucleotide gated channel alpha 3 s homeolog)
B: cnga3 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 3)
C: cnga3 (sus scrofa) (aka cyclic nucleotide gated channel subunit alpha 3)
D: cnga3 (xenopus tropicalis) (aka cyclic nucleoti... | [B] |
<Instruct>: Given the context 'We report the identification of missense mutations in CNGA3 in five families with RM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cnga3]
<Options>: A: cnga3.s (xenopus laevis) (aka cyclic nucleotide gated channel alpha 3 s homeolog)
B: cnga3 (sus scrofa) (aka cyclic nucleotide gated channel subunit alpha 3)
C: cnga3 (xenopus tropicalis) (aka cyclic nucleotide gated channel alpha 3)
D: cnga3 (mus musculus) (aka cyclic nucleotide gated... | [E] |
<Instruct>: Given the context 'The locus for the incomplete form of X-linked congenital stationary night blindness (CSNB2) maps to a 1.1-Mb region in Xp11.23 between markers DXS722 and DXS255.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [csnb2]
<Options>: A: csnb1c (homo sapiens) (aka transient receptor potential cation channel subfamily m member 1)
B: csnb1b (homo sapiens) (aka glutamate metabotropic receptor 6)
C: csn1s2b (homo sapiens) (aka casein alpha s2 like b, pseudogene)
D: csnb2a (homo sapiens) (aka calcium voltage-gated channel s... | [D] |
<Instruct>: Given the context 'We identified a retina-specific calcium channel alpha1-subunit gene (CACNA1F) in this region, consisting of 48 exons encoding 1966 amino acids and showing high homology to L-type calcium channel alpha1-subunits.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [cacna1f]
<Options>: A: cacna1f (xenopus tropicalis) (aka calcium channel, voltage-dependent, l type, alpha 1f subunit)
B: cacna1h (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 h)
C: cacna1f (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 f)
D: cacna1s (homo sapiens) (aka... | [C] |
<Instruct>: Given the context 'Mutation analysis in 13 families with CSNB2 revealed nine different mutations in 10 families, including three nonsense and one frameshift mutation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [csnb2]
<Options>: A: csnb1c (homo sapiens) (aka transient receptor potential cation channel subfamily m member 1)
B: csnk2b (homo sapiens) (aka casein kinase 2 beta)
C: csn2 (bos taurus) (aka casein beta)
D: csnbx2 (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 f)
E: csnb2b (homo sapiens)... | [D] |
<Instruct>: Given the context 'These data indicate that aberrations in a voltage-gated calcium channel, presumably causing a decrease in neurotransmitter release from photoreceptor presynaptic terminals, are a frequent cause of CSNB2.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [csnb2]
<Options>: A: csnb1c (homo sapiens) (aka transient receptor potential cation channel subfamily m member 1)
B: csnb2b (homo sapiens) (aka calcium binding protein 4)
C: csnb1 (homo sapiens) (aka nyctalopin)
D: csnb2 (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 f)
E: csnk2b (homo sa... | [D] |
<Instruct>: Given the context 'ZW10 helps recruit dynactin and dynein to the kinetochore.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [zw10]
<Options>: A: zw10 (xenopus tropicalis) (aka zw10 kinetochore protein)
B: zw10 (homo sapiens) (aka zw10 kinetochore protein)
C: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_f20d12.4 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
D: zw10 kinet... | [B] |
<Instruct>: Given the context 'Mutations in the Drosophila melanogaster zw10 gene, which encodes a conserved, essential kinetochore component, abolish the ability of dynein to localize to kinetochores.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [zw10]
<Options>: A: zw10 (danio rerio) (aka zw10 kinetochore protein)
B: zw10 (drosophila melanogaster) (aka zeste-white 10)
C: zw10 (homo sapiens) (aka zw10 kinetochore protein)
D: zw10 kinetochore protein s homeolog (xenopus laevis) (aka zw10 kinetochore protein s homeolog)
E: zw10 (xenopus tropicalis) (... | [B] |
<Instruct>: Given the context 'Several similarities between the behavior of ZW10 protein and dynein further support a role for ZW10 in the recruitment of dynein to the kinetochore: (a) in response to bipolar tension across the chromosomes, both proteins mostly leave the kinetochore at metaphase, when their association ... | <Mentions>: [zw10]
<Options>: A: zw10 (danio rerio) (aka zw10 kinetochore protein)
B: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_f20d12.4 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
C: zw10 (homo sapiens) (aka zw10 kinetochore protein)
D: zw-10 (drosophila... | [C] |
<Instruct>: Given the context 'ZW10's role in the recruitment of dynein to the kinetochore is likely to be reasonably direct, because dynamitin, the p50 subunit of the dynactin complex, interacts with ZW10 in a yeast two-hybrid screen.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [zw10; dynamitin]
<Options>: A: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_d2030.11 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
B: dynactin subunit 2 (homo sapiens) (aka dynactin subunit 2)
C: dynamitin (xenopus laevis) (dynactin subunit 2 s ho... | [H; B] |
<Instruct>: Given the context 'ZW10's role in the recruitment of dynein to the kinetochore is likely to be reasonably direct, because dynamitin, the p50 subunit of the dynactin complex, interacts with ZW10 in a yeast two-hybrid screen.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [zw10; dynamitin]
<Options>: A: zw10 (homo sapiens) (aka zw10 kinetochore protein)
B: drn (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
C: dynactin subunit 2 (homo sapiens) (aka dynactin subunit 2)
D: dynamitin (xenopus laevis) (dynactin subunit ... | [A; C] |
<Instruct>: Given the context 'Since in zw10 mutants no defects in chromosome behavior are observed before anaphase onset, our results suggest that dynein at the kinetochore is essential for neither microtubule capture nor congression to the metaphase plate.', select the correct biomedical concept for each mention usin... | <Mentions>: [zw10]
<Options>: A: zw10 kinetochore protein s homeolog (xenopus laevis) (aka zw10 kinetochore protein s homeolog)
B: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_d2030.11 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
C: centromere/kinetochore pro... | [D] |
<Instruct>: Given the context 'The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations.
IFI 16 is an interferon-inducible nucleoprotein expressed by human monocytes.', select the correct biomedical concept fo... | <Mentions>: [ifn-inducible nucleoprotein ifi 16; ifi 16]
<Options>: A: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
B: ifi16 (mus musculus) (aka interferon activated gene 204)
C: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
D: ifi17 (homo sapiens) (aka interferon induced transmembran... | [G; G] |
<Instruct>: Given the context 'The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations.
IFI 16 is an interferon-inducible nucleoprotein expressed by human monocytes.', select the correct biomedical concept fo... | <Mentions>: [ifn-inducible nucleoprotein ifi 16; ifi 16]
<Options>: A: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
B: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
C: nod16 (homo sapiens) (aka nlr family pyrin domain containing 8)
D: translation machinery associated 16 homolog ... | [E; E] |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [ifi 16; p202; p53; retinoblastoma gene product, prb]
<Options>: A: p200b (homo sapiens) (aka heat repeat containing 5a)
B: rb-1 (homo sapiens) (aka rna binding motif protein 45)
C: p28 (drosophila melanogaster) (tbp-associated factor 12 (drosophila melanogaster)) (aka tbp-associated factor 12)
D: ifi16 (ho... | [D; U; H; R] |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [ifi 16; p202; p53; retinoblastoma gene product, prb]
<Options>: A: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
B: p105-rb (homo sapiens) (aka rb transcriptional corepressor 1)
C: prb1 (homo sapiens) (rb transcriptional corepressor like 1 (homo sapiens)) (aka rb transcriptional cor... | [T; T; R; B] |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [ifi 16; p202; p53; retinoblastoma gene product, prb]
<Options>: A: tp73 (homo sapiens) (aka tumor protein p73)
B: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
C: rb (drosophila melanogaster) (retinoblastoma-family protein 2 (drosophila melanogaster)) (aka retinoblastoma-family protein 2)
D: ct5... | [J; U; R; T] |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [ifi 16; p202; p53; retinoblastoma gene product, prb]
<Options>: A: rbb (homo sapiens) (aka nacc family member 2)
B: rad53 (homo sapiens) (aka checkpoint kinase 2)
C: p18-20 (homo sapiens) (aka cd59 molecule (cd59 blood group))
D: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like pro... | [H; U; O; Q] |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [ifi 16; p202; p53; retinoblastoma gene product, prb]
<Options>: A: p200b (homo sapiens) (aka heat repeat containing 5a)
B: ct53 (homo sapiens) (aka zinc finger protein 165)
C: p53 (homo sapiens) (aka tumor protein p53)
D: ifi16 (mus musculus) (aka interferon activated gene 204)
E: rb-1 (homo sapiens) (aka ... | [H; U; C; F] |
<Instruct>: Given the context 'In this study, we examined IFI 16 expression in myeloid precursor cells cultured in vitro in colony-forming assays using granulocyte (G-) and granulocyte-macrophage (GM-) colony-stimulating factor (CSF).', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [ifi 16]
<Options>: A: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
B: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
C: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
D: glyi-16 (glycine max) (aka ... | [B] |
<Instruct>: Given the context 'IFI 16 was expressed in 100% of CD34+ cells isolated from human bone marrow.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16; cd34]
<Options>: A: cd34 molecule (gallus gallus) (aka cd34 molecule)
B: cd34 (sus scrofa) (aka cd34 molecule)
C: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
D: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associa... | [H; G] |
<Instruct>: Given the context 'IFI 16 was expressed in 100% of CD34+ cells isolated from human bone marrow.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16; cd34]
<Options>: A: cd34 (gallus gallus) (aka cd34 molecule)
B: fat4 (homo sapiens) (aka fat atypical cadherin 4)
C: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
D: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
E: ifi6 (homo sapiens) (aka interferon alpha in... | [G; I] |
<Instruct>: Given the context 'When the CD34+ cells were induced to differentiate, two sub-populations of cells were identified by two-color cytofluorography: the CD14+ (monocytoid) cells all expressed IFI 16, whereas the CD14- (polymorphonuclear precursor) cells did not.', select the correct biomedical concept for eac... | <Mentions>: [cd34; cd14; ifi 16]
<Options>: A: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
B: cd14 (homo sapiens) (cd14 molecule (homo sapiens)) (aka cd14 molecule)
C: cd34 molecule (homo sapiens) (aka cd34 molecule)
D: cd14 molecule (oryctolagus cuniculus) (aka cd14... | [C; B; A] |
<Instruct>: Given the context 'When the CD34+ cells were induced to differentiate, two sub-populations of cells were identified by two-color cytofluorography: the CD14+ (monocytoid) cells all expressed IFI 16, whereas the CD14- (polymorphonuclear precursor) cells did not.', select the correct biomedical concept for eac... | <Mentions>: [cd34; cd14; ifi 16]
<Options>: A: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
B: cd146 (homo sapiens) (aka melanoma cell adhesion molecule)
C: cd141 (homo sapiens) (aka thrombomodulin)
D: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
E: fat4 (homo sapiens) (aka f... | [O; M; G] |
<Instruct>: Given the context 'When the CD34+ cells were induced to differentiate, two sub-populations of cells were identified by two-color cytofluorography: the CD14+ (monocytoid) cells all expressed IFI 16, whereas the CD14- (polymorphonuclear precursor) cells did not.', select the correct biomedical concept for eac... | <Mentions>: [cd34; cd14; ifi 16]
<Options>: A: cd344 (homo sapiens) (aka frizzled class receptor 4)
B: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
C: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
D: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
E: cd34... | [F; N; M] |
<Instruct>: Given the context 'When the CD34+ cells were induced to differentiate, two sub-populations of cells were identified by two-color cytofluorography: the CD14+ (monocytoid) cells all expressed IFI 16, whereas the CD14- (polymorphonuclear precursor) cells did not.', select the correct biomedical concept for eac... | <Mentions>: [cd34; cd14; ifi 16]
<Options>: A: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
B: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
C: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
D: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
E: cd14 molecule (... | [G; N; B] |
<Instruct>: Given the context 'The strongest expression of IFI 16 was in the cells staining brightest for CD14, whereas depletion of CD14+ monocytoid cells from mixed monocytic/granulocytic cultures largely abolished IFI 16-stained cells.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [ifi 16; cd14]
<Options>: A: cd147 (homo sapiens) (aka basigin (ok blood group))
B: cd14 (homo sapiens) (cd14 molecule (homo sapiens)) (aka cd14 molecule)
C: cd142 (homo sapiens) (aka coagulation factor iii, tissue factor)
D: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)... | [G; B] |
<Instruct>: Given the context 'The strongest expression of IFI 16 was in the cells staining brightest for CD14, whereas depletion of CD14+ monocytoid cells from mixed monocytic/granulocytic cultures largely abolished IFI 16-stained cells.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [ifi 16; cd14]
<Options>: A: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
B: cd142 (homo sapiens) (aka coagulation factor iii, tissue factor)
C: cd14 molecule (homo sapiens) (aka cd14 molecule)
D: cd140a (homo sapiens) (aka platelet derived growth factor receptor alpha)... | [J; C] |
<Instruct>: Given the context 'The strongest expression of IFI 16 was in the cells staining brightest for CD14, whereas depletion of CD14+ monocytoid cells from mixed monocytic/granulocytic cultures largely abolished IFI 16-stained cells.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [ifi 16; cd14]
<Options>: A: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
B: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
C: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation ... | [A; J] |
<Instruct>: Given the context 'Furthermore, in eight independent colony-forming assays, the number of IFI 16+ cells correlated closely with the numbers of monocyte precursors identified morphologically (R2 = 0.99), but was unrelated to the numbers of myelocytes, promyelocytes, and metamyelocytes; nor was IFI 16 express... | <Mentions>: [ifi 16]
<Options>: A: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
B: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
C: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
D: glyi-16 (glycine max) (aka... | [B] |
<Instruct>: Given the context 'We conclude that IFI 16 is expressed in CD34+ and monocytoid daughter cells, but is rapidly and markedly down-regulated at the corresponding stages of polymorphonuclear and erythroid development.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [ifi 16; cd34]
<Options>: A: fat4 (homo sapiens) (aka fat atypical cadherin 4)
B: ifi16 (mus musculus) (aka interferon activated gene 204)
C: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
D: cd34 (gallus gallus) (aka cd34 molecule)
E: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka c... | [J; E] |
<Instruct>: Given the context 'We conclude that IFI 16 is expressed in CD34+ and monocytoid daughter cells, but is rapidly and markedly down-regulated at the corresponding stages of polymorphonuclear and erythroid development.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [ifi 16; cd34]
<Options>: A: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
B: fat4 (homo sapiens) (aka fat atypical cadherin 4)
C: ifi16 (mus musculus) (aka interferon activated gene 204)
D: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
E: c... | [D; F] |
<Instruct>: Given the context 'This differential expression of IFI 16 in myeloid precursor subpopulations and its perceived molecular properties are consistent with a possible role in regulating myelopoiesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sele... | <Mentions>: [ifi 16]
<Options>: A: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
B: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
C: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 1... | [C] |
<Instruct>: Given the context 'A novel candidate oncogene, MCT-1, is involved in cell cycle progression.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1]
<Options>: A: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
B: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
C: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
D: slc16a6 (homo sapiens) (aka solute carrier family 16 member 6)
E: mct (homo sapiens) ... | [C] |
<Instruct>: Given the context 'We termed this novel gene with multiple copies in a T-cell malignancy as MCT-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1]
<Options>: A: solute carrier family 16 member 1 (homo sapiens) (aka solute carrier family 16 member 1)
B: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
C: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
D: mct-1 (homo sapiens) (aka mcts1 re-initiation and release fact... | [D] |
<Instruct>: Given the context 'MCT-1 was localized to the long arm of chromosome Xq22-24 by flourescence in situ hybridization analysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1]
<Options>: A: mct (homo sapiens) (solute carrier family 16 member 1 (homo sapiens)) (aka solute carrier family 16 member 1)
B: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
C: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
D: monocarboxylate transporter 1 (bos tau... | [B] |
<Instruct>: Given the context 'Although there was no significant homology at the primary sequence level, there was a limited degree of amino acid homology with a domain of cyclin H that appears to specify protein-protein complexes.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [cyclin h]
<Options>: A: cyclin h (gallus gallus) (aka cyclin h)
B: cyclin p (homo sapiens) (aka cyclin p)
C: cyclin h (homo sapiens) (aka cyclin h)
D: ccnc (homo sapiens) (aka cyclin c)
E: cyclin g1 (homo sapiens) (aka cyclin g1)
F: None of the above. | [C] |
<Instruct>: Given the context 'Although there was no significant homology at the primary sequence level, there was a limited degree of amino acid homology with a domain of cyclin H that appears to specify protein-protein complexes.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [cyclin h]
<Options>: A: cyclin g1 (homo sapiens) (aka cyclin g1)
B: cyclin p (homo sapiens) (aka cyclin p)
C: ccnc (homo sapiens) (aka cyclin c)
D: cyclin h (gallus gallus) (aka cyclin h)
E: None of the above. | [E] |
<Instruct>: Given the context 'This relationship between MCT-1 and cyclin H implied a potential role for MCT-1 in cell cycle regulation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1; cyclin h]
<Options>: A: p34 (homo sapiens) (cyclin h (homo sapiens)) (aka cyclin h)
B: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
C: cyclin g1 (homo sapiens) (aka cyclin g1)
D: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
E: cyclin p (homo sapiens) (aka cyclin p... | [H; A] |
<Instruct>: Given the context 'This relationship between MCT-1 and cyclin H implied a potential role for MCT-1 in cell cycle regulation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1; cyclin h]
<Options>: A: ccnc (homo sapiens) (aka cyclin c)
B: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
C: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
D: cyclin p (homo sapiens) (aka cyclin p)
E: p34 (homo sapiens) (cyclin h (homo sapiens)) (aka cyclin h)
F: m... | [F; E] |
<Instruct>: Given the context 'Overexpression of MCT-1 increased the proliferative rate of cells by decreasing the length of the G1 phase without a reciprocal increase in the S and G2-M phases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [mct-1]
<Options>: A: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
B: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
C: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
D: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
E: slc... | [A] |
<Instruct>: Given the context 'Therefore, we investigated the transforming ability of MCT-1 overexpression using soft agar growth assays and demonstrated that only MCT-1-overexpressing cells were able to establish colonies.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [mct-1]
<Options>: A: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
B: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
C: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
D: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
E: slc... | [B] |
<Instruct>: Given the context 'Taken together, MCT-1 is a novel candidate oncogene with homology to a protein-protein binding domain of cyclin H.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1; cyclin h]
<Options>: A: ccng (homo sapiens) (aka cyclin g1)
B: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
C: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
D: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
E: cyclin h (gallus gallus) (aka cyclin... | [C; H] |
<Instruct>: Given the context 'Taken together, MCT-1 is a novel candidate oncogene with homology to a protein-protein binding domain of cyclin H.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1; cyclin h]
<Options>: A: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
B: cyclin p (homo sapiens) (aka cyclin p)
C: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
D: slc16a1 (homo sapiens) (aka solute carrier family 16 member 1)
E: slc16a6 (homo sapien... | [J; G] |
<Instruct>: Given the context 'Taken together, MCT-1 is a novel candidate oncogene with homology to a protein-protein binding domain of cyclin H.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1; cyclin h]
<Options>: A: ccng (homo sapiens) (aka cyclin g1)
B: cyclin p (homo sapiens) (aka cyclin p)
C: ccnc (homo sapiens) (aka cyclin c)
D: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
E: cyclin h (gallus gallus) (aka cyclin h)
F: slc16a6 (homo sapiens) (aka solute carrier famil... | [H; J] |
<Instruct>: Given the context 'Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [3alpha-hydroxysteroid dehydrogenase; akr1c3]
<Options>: A: 24-dehydrocholesterol reductase (homo sapiens) (aka 24-dehydrocholesterol reductase)
B: 3alpha-hsd (homo sapiens) (aka dehydrogenase/reductase 9)
C: akr1c3 (rattus norvegicus) (aka aldo-keto reductase family 1, member c3)
D: 17-beta-hsd (homo sapie... | [F; F] |
<Instruct>: Given the context 'Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [3alpha-hydroxysteroid dehydrogenase; akr1c3]
<Options>: A: akr6a3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
B: akr1b1 (homo sapiens) (aka aldo-keto reductase family 1 member b)
C: 24-dehydrocholesterol reductase (homo sapiens) (aka 24-dehydrocholesterol redu... | [D; D] |
<Instruct>: Given the context 'Human 3alpha-hydroxysteroid dehydrogenase exists in four isoforms, which belong to the aldo-keto reductase (AKR) superfamily and are named AKR1C1-AKR1C4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [3alpha-hydroxysteroid dehydrogenase]
<Options>: A: hydroxysteroid 17-beta dehydrogenase 3 (homo sapiens) (aka hydroxysteroid 17-beta dehydrogenase 3)
B: 7-dehydrocholesterol reductase (homo sapiens) (aka 7-dehydrocholesterol reductase)
C: 3alpha-hsd (homo sapiens) (aka dehydrogenase/reductase 9)
D: 24-dehy... | [F] |
<Instruct>: Given the context 'The properties of AKR1C3 have not been fully characterized compared to the other isoforms.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [akr1c3]
<Options>: A: akr1c-pseudo (homo sapiens) (aka aldo-keto reductase family 1 member c2)
B: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
C: akr6a3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
D: akr1c3 (sus scrofa) (aka aldo-keto red... | [B] |
<Instruct>: Given the context 'In addition, a cDNA that shows more than 99% homology with AKR1C3 cDNA has been cloned from human myeloblasts.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [akr1c3]
<Options>: A: akr1c1 (homo sapiens) (aka aldo-keto reductase family 1 member c1)
B: akr1c-pseudo (homo sapiens) (aka aldo-keto reductase family 1 member c2)
C: akr7a3 (homo sapiens) (aka aldo-keto reductase family 7 member a3)
D: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
E:... | [D] |
<Instruct>: Given the context 'The recombinant AKR1C3 prepared by site-directed mutagenesis of DBDH also showed the same properties as the wild-type DBDH.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [akr1c3]
<Options>: A: akr6a3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
B: akr1c3 (rattus norvegicus) (aka aldo-keto reductase family 1, member c3)
C: akr1c1 (homo sapiens) (aka aldo-keto reductase family 1 member c1)
D: akr1c3 (homo sapiens) (aka aldo-keto r... | [D] |
<Instruct>: Given the context 'Analyses of expression of mRNAs for DBDH and AKR1C3 by reverse transcription-PCR indicated that only one mRNA species for DBDH is expressed in 33 human specimens of liver, kidney, lung, brain, heart, spleen, adrenal gland, small intestine, placenta, prostate, and testis.', select the corr... | <Mentions>: [akr1c3]
<Options>: A: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
B: akr1c-pseudo (homo sapiens) (aka aldo-keto reductase family 1 member c2)
C: akr1c3 (rattus norvegicus) (aka aldo-keto reductase family 1, member c3)
D: akr7a3 (homo sapiens) (aka aldo-keto reductase family 7 member ... | [A] |
<Instruct>: Given the context 'These results suggest that AKR1C3 acts as prostaglandin D2 11-ketoreductase, and that its principal gene in the human has a coding region represented by DBDH cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [akr1c3]
<Options>: A: akr7a3 (homo sapiens) (aka aldo-keto reductase family 7 member a3)
B: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
C: akr1c3 (sus scrofa) (aka aldo-keto reductase family 1 member c3)
D: akr6a3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regula... | [B] |
<Instruct>: Given the context 'These results suggest that AKR1C3 acts as prostaglandin D2 11-ketoreductase, and that its principal gene in the human has a coding region represented by DBDH cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [akr1c3]
<Options>: A: akr1c3 (sus scrofa) (aka aldo-keto reductase family 1 member c3)
B: akr6a3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
C: akr7a3 (homo sapiens) (aka aldo-keto reductase family 7 member a3)
D: akr1b3 (mus musculus) (aka aldo-keto reductase... | [E] |
<Instruct>: Given the context 'In this study, we have identified a previously unclassified aldoketoreductase family member (termed HAKR e) that is expressed in HL60 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [hakr e]
<Options>: A: hakrc (homo sapiens) (aka aldo-keto reductase family 1 member c1)
B: klkr (homo sapiens) (aka kallikrein 1)
C: ackr2 (homo sapiens) (aka atypical chemokine receptor 2)
D: hakre (homo sapiens) (aka aldo-keto reductase family 1 member c3)
E: hbrek (homo sapiens) (aka lemur tyrosine kina... | [D] |
<Instruct>: Given the context 'HAKR e is dramatically and transiently up-regulated in HL60 cells within 24 h of exposure to ATRA, further supporting the proposition that a member(s) of this family of enzymes play(s) a role in controlling cell growth and/or differentiation.', select the correct biomedical concept for ea... | <Mentions>: [hakr e]
<Options>: A: hbrek (homo sapiens) (aka lemur tyrosine kinase 2)
B: hakrd (homo sapiens) (aka aldo-keto reductase family 1 member c2)
C: hakra (homo sapiens) (aka aldo-keto reductase family 1 member c4)
D: hakrb (homo sapiens) (aka aldo-keto reductase family 1 member c3)
E: hakrc (homo sapiens) (ak... | [D] |
<Instruct>: Given the context 'G protein-coupled receptors such as the receptors for bradykinin are present in low copy numbers in most natural cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [bradykinin]
<Options>: A: kallikrein b1 (bos taurus) (aka kallikrein b1)
B: bradykinin receptor b2 (homo sapiens) (aka bradykinin receptor b2)
C: kininogen 1 (bos taurus) (aka kininogen 1)
D: kallikrein (homo sapiens) (aka kallikrein related peptidase 4)
E: bk (homo sapiens) (aka kininogen 1)
F: None of th... | [E] |
<Instruct>: Given the context 'The B1 receptor failed to undergo ligand-induced phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [b1 receptor]
<Options>: A: b1ar (homo sapiens) (aka adrenoceptor beta 1)
B: b1bkr (homo sapiens) (aka bradykinin receptor b1)
C: npbwr1 (bos taurus) (aka neuropeptides b and w receptor 1)
D: bradykinin receptor b1 (bos taurus) (aka bradykinin receptor b1)
E: adhesion g protein-coupled receptor b1 (homo sap... | [B] |
<Instruct>: Given the context 'However the B2 receptor showed selective phosphorylation of a minor 38 kDa band and lack of phosphorylation of a dominant 33 kDa band, indicating that only a fraction of the receptor protein is functionally linked to the kinase pathway.', select the correct biomedical concept for each men... | <Mentions>: [b2 receptor]
<Options>: A: bradykinin receptor b2 (homo sapiens) (aka bradykinin receptor b2)
B: bkb1r (homo sapiens) (aka bradykinin receptor b1)
C: b2ar (homo sapiens) (aka adrenoceptor beta 2)
D: bb2r (homo sapiens) (aka gastrin releasing peptide receptor)
E: blr2 (homo sapiens) (aka c-c motif chemokine... | [A] |
<Instruct>: Given the context 'Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
B: or2h1b (mus musculus) (aka olfactory receptor family 2 subfamily h member 1b)
C: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory receptor family 8 s... | [A; K] |
<Instruct>: Given the context 'Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 homolog, double strand break repair nuclease (gallus gallus) (aka mre11 homolog, double strand break repair nuclease)
B: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka meiotic recombination 11)
C: hmre11b (homo sapiens) (aka mre... | [C; K] |
<Instruct>: Given the context 'The Saccharomyces cerevisiae MRE11 gene plays an important role in meiotic recombination, mitotic DNA repair and telomere maintenance.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separat... | <Mentions>: [mre11]
<Options>: A: mre11a homolog a, double strand break repair nuclease (mus musculus) (aka mre11a homolog a, double strand break repair nuclease)
B: mre11 (drosophila melanogaster) (igf-ii mrna-binding protein (drosophila melanogaster)) (aka igf-ii mrna-binding protein)
C: mre11 homolog, double strand ... | [F] |
<Instruct>: Given the context 'We present the isolation of hMRE11B cDNA from a human HeLa cell cDNA library as an MRE11 homolog.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
B: mre11 homolog, double strand break repair nuclease (gallus gallus) (aka mre11 homolog, double strand break repair nuclease)
C: olfactory receptor... | [H; K] |
<Instruct>: Given the context 'We present the isolation of hMRE11B cDNA from a human HeLa cell cDNA library as an MRE11 homolog.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
B: mre11 (drosophila melanogaster) (igf-ii mrna-binding protein (drosophila melanogaster)) (aka igf-ii mrna-binding protein)
C: or11h4b (mus musculus) (aka olfactory receptor family 11 subfamily h ... | [F; K] |
<Instruct>: Given the context 'Compared to the previously identified hMRE11, hMRE11B contains an additional 84bp sequence that results in a 28 amino-acid insertion close to the C-terminus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [hmre11; hmre11b]
<Options>: A: hsd11b (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
B: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
C: olfactory receptor family 11 subfamily h member 12b (bos taurus) (aka olfactory receptor family 11 subfamily h... | [J; B] |
<Instruct>: Given the context 'Compared to the previously identified hMRE11, hMRE11B contains an additional 84bp sequence that results in a 28 amino-acid insertion close to the C-terminus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [hmre11; hmre11b]
<Options>: A: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
B: ccr4-not transcription complex, subunit 11 (mus musculus) (aka ccr4-not transcription complex, subunit 11)
C: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
D: ol... | [J; I] |
<Instruct>: Given the context 'The expression pattern of hMRE11B in different tissues shows the presence of two mRNA species of approx.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b]
<Options>: A: hsd11b (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
B: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory receptor family 8 subfamily b member 12b)
C: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory recept... | [E] |
<Instruct>: Given the context 'Overexpression of hMRE11B does not complement the alkylation sensitivity of the mre11 null and temperature-sensitive mutant strains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [hmre11b; mre11]
<Options>: A: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
B: mre11 (homo sapiens) (aka mre11 double strand break repair nuclease)
C: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamil... | [A; K] |
<Instruct>: Given the context 'Overexpression of hMRE11B does not complement the alkylation sensitivity of the mre11 null and temperature-sensitive mutant strains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 double strand break repair nuclease (homo sapiens) (aka mre11 double strand break repair nuclease)
B: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
C: hsd11b (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
D: olf... | [B; K] |
<Instruct>: Given the context 'First, both Northern and Western analyses rule out the lack of hMRE11B transcription and/or translation in yeast.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b]
<Options>: A: or11h4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
B: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
C: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subf... | [B] |
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